The front cover illustrates the cooperative action between organolithium reagents (RLi) and alcohol dehydrogenases (ADHs). This chemoenzymatic strategy facilitates the conversion of a range of aromatic nitriles into chiral alcohols. The critical aspect of this research was identifying optimal conditions that allow both RLi and ADHs to function effectively in the same reaction vessel. Details of the studies can be found in the research article by Joaquín García-Álvarez and co-workers (N. Ríos-Lombardía, G. Morís-Menéndez, I. Lavandera, V. Gotor-Fernández, J. García-Álvarez, Adv. Synth. Catal. 2024, 366, 3144–3152; DOI: 10.1002/adsc.202400460)
{"title":"Front Cover Picture: Merging Organolithium Chemistry and Stereoselective Biocatalysis: Transformation of Aromatic Nitriles into Chiral Alcohols (Adv. Synth. Catal. 14/2024)","authors":"Nicolás Ríos-Lombardía, Gloria Morís-Menéndez, Iván Lavandera, Vicente Gotor-Fernández, Joaquín García-Álvarez","doi":"10.1002/adsc.202400776","DOIUrl":"10.1002/adsc.202400776","url":null,"abstract":"<p>The front cover illustrates the cooperative action between organolithium reagents (RLi) and alcohol dehydrogenases (ADHs). This chemoenzymatic strategy facilitates the conversion of a range of aromatic nitriles into chiral alcohols. The critical aspect of this research was identifying optimal conditions that allow both RLi and ADHs to function effectively in the same reaction vessel. Details of the studies can be found in the research article by Joaquín García-Álvarez and co-workers (N. Ríos-Lombardía, G. Morís-Menéndez, I. Lavandera, V. Gotor-Fernández, J. García-Álvarez, <i>Adv. Synth. Catal</i>. <b>2024</b>, <i>366</i>, 3144–3152; DOI: 10.1002/adsc.202400460)\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":4.4,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsc.202400776","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141754292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shang-Shi Zhang, Dan-Ting Shen, Wen-Xuan Zou, Shao-Yong Chen, Lin Xiao, Qiong Hu, Jia-Lin Song, Xu-Ge Liu
A method for synthesizing pyrimido[1,2-a]indol-4-ol heteroarenes via a Cp*Rh(III)-catalyzed cascade C-H activation/annulation strategy employing N-methoxyindoleamides and isoxazolones is developed. Also, a framework of 3-methoxy-2,3-dihydro-[1,3,5]triazino[1,2-a]indole-4,10-dione was successfully synthesized via a Cp*Rh-catalyzed C-H activation/annulation/oxidation reaction between N-(methyloxy)-1H-indole-1-carboxamide and isoxazolones. These reactions demonstrated the suitability of several substrates, compatibility with numerous functional groups, and mild reaction conditions. Preliminary mechanistic investigations have been completed.
{"title":"Cp*Rh(III)-Catalyzed Divergent Synthesis of N-heterocycles with N-methoxyindoleamides and Isoxazolones","authors":"Shang-Shi Zhang, Dan-Ting Shen, Wen-Xuan Zou, Shao-Yong Chen, Lin Xiao, Qiong Hu, Jia-Lin Song, Xu-Ge Liu","doi":"10.1002/adsc.202400425","DOIUrl":"https://doi.org/10.1002/adsc.202400425","url":null,"abstract":"A method for synthesizing pyrimido[1,2-a]indol-4-ol heteroarenes via a Cp*Rh(III)-catalyzed cascade C-H activation/annulation strategy employing N-methoxyindoleamides and isoxazolones is developed. Also, a framework of 3-methoxy-2,3-dihydro-[1,3,5]triazino[1,2-a]indole-4,10-dione was successfully synthesized via a Cp*Rh-catalyzed C-H activation/annulation/oxidation reaction between N-(methyloxy)-1H-indole-1-carboxamide and isoxazolones. These reactions demonstrated the suitability of several substrates, compatibility with numerous functional groups, and mild reaction conditions. Preliminary mechanistic investigations have been completed.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xinyu Zhang, Xuan Zhao, Die Wu, Jingsa Zhang, Yilu Shou, Xingya Wang, Yongmin Ma, Bihong Zhu
The synthesis of substituted 3‐oxo‐pyrimido[1,2‐b]indazoles from 3‐aminoindazoles and ketones has been established. It involves one molecule of 3‐aminoindazoles and two molecules of ketones via a [3+2+1] three‐component annulation process. 3‐Oxo‐pyrimido[1,2‐b]indazoles exhibit strong yellow fluorescence in various solvents. A wide range of products have anti‐oxidant activities. Cytotoxicity studies indicate that compounds 3a, 3aa and 3ab have obvious effects on both HCT116 and A549 cancer cell lines.
{"title":"Synthesis, Characterization and Biological Evaluation of 3‐Oxo‐pyrimido[1,2‐b]indazoles","authors":"Xinyu Zhang, Xuan Zhao, Die Wu, Jingsa Zhang, Yilu Shou, Xingya Wang, Yongmin Ma, Bihong Zhu","doi":"10.1002/adsc.202400739","DOIUrl":"https://doi.org/10.1002/adsc.202400739","url":null,"abstract":"The synthesis of substituted 3‐oxo‐pyrimido[1,2‐b]indazoles from 3‐aminoindazoles and ketones has been established. It involves one molecule of 3‐aminoindazoles and two molecules of ketones via a [3+2+1] three‐component annulation process. 3‐Oxo‐pyrimido[1,2‐b]indazoles exhibit strong yellow fluorescence in various solvents. A wide range of products have anti‐oxidant activities. Cytotoxicity studies indicate that compounds 3a, 3aa and 3ab have obvious effects on both HCT116 and A549 cancer cell lines.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng-Jie Wu, Xu Jiang, Jia-Yi Qiu, Ming-Yang Wang, Wei Li
Dearomative trifluoromethylation of arenes provides an ideal method for constructing CF3-containing three-dimensional architectures which are of increasing interest in drug discovery. However, such transformation is rare and challenging because of the inherently low reactivity of arene π-systems and selectivity issues. Herein, we disclose a general dearomative 1,2-hydrotrifluoromethylation of (hetero)arenes utilizing activation by temporary π-complexation to chromium, thus affording convenient access to 1,3-cyclohexadienes bearing the privileged CF3 group. The versatility of this strategy further enables a dearomative 1,2-deuterotrifluoromethylation with high deuterated ratios. The related dearomative 1,2-(deutero)hydroperfluoroethylation reactions were conducted well for a range of chromium-bound (hetero)arenes. Finally, a reasonable mechanism was proposed based on the intermediate capture and control experiments.
炔烃的三氟甲基化反应（Dearomative trifluoromethylation of arenes）为构建含 CF3 的三维结构提供了一种理想的方法，这种结构在药物发现中的应用越来越受到关注。然而，由于炔烃 π 系统固有的低反应活性和选择性问题，这种转化非常罕见且具有挑战性。在此，我们揭示了一种利用与铬的临时π-络合活化对（杂）炔类化合物进行一般脱芳1,2-氢三氟甲基化的方法，从而方便地获得带有特选CF3基团的1,3-环己二烯。这种策略的多功能性进一步实现了高氚化比率的 1,2-氚三氟甲基化反应。对于一系列铬结合（杂）烷，相关的 1,2-(氘代)氢全氟乙基化反应进行得很好。最后，根据中间体捕获和控制实验提出了合理的机理。
{"title":"Dearomative 1,2-(Deutero)Hydrotrifluoromethylation of Chromium-Bound Arenes","authors":"Cheng-Jie Wu, Xu Jiang, Jia-Yi Qiu, Ming-Yang Wang, Wei Li","doi":"10.1002/adsc.202400718","DOIUrl":"https://doi.org/10.1002/adsc.202400718","url":null,"abstract":"Dearomative trifluoromethylation of arenes provides an ideal method for constructing CF3-containing three-dimensional architectures which are of increasing interest in drug discovery. However, such transformation is rare and challenging because of the inherently low reactivity of arene π-systems and selectivity issues. Herein, we disclose a general dearomative 1,2-hydrotrifluoromethylation of (hetero)arenes utilizing activation by temporary π-complexation to chromium, thus affording convenient access to 1,3-cyclohexadienes bearing the privileged CF3 group. The versatility of this strategy further enables a dearomative 1,2-deuterotrifluoromethylation with high deuterated ratios. The related dearomative 1,2-(deutero)hydroperfluoroethylation reactions were conducted well for a range of chromium-bound (hetero)arenes. Finally, a reasonable mechanism was proposed based on the intermediate capture and control experiments.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this work, silyl ethers of phenols and alcohols have been successfully prepared and tested as neutral carbon (silicon) centered radical precursors. The organocophotocatalyzed oxidation (by the Fukuzumi catalyst) of these ethers caused the cleavage of a C-Si (or a Si-Si) bond for the release of the desired radical to be used for the forging of C(sp3)-C(sp3) (or C(sp3)-Si) bonds via a Giese reaction.
{"title":"Organophotocatalyzed C-Si Bond Fragmentation Using Silyl Ethers as Radical Precursors","authors":"Adrian Luguera Ruiz, Valentina Benazzi, Federico Tucci, Francesca Rizzo, Daniele Merli, Stefano Protti, Maurizio Fagnoni","doi":"10.1002/adsc.202400584","DOIUrl":"https://doi.org/10.1002/adsc.202400584","url":null,"abstract":"In this work, silyl ethers of phenols and alcohols have been successfully prepared and tested as neutral carbon (silicon) centered radical precursors. The organocophotocatalyzed oxidation (by the Fukuzumi catalyst) of these ethers caused the cleavage of a C-Si (or a Si-Si) bond for the release of the desired radical to be used for the forging of C(sp3)-C(sp3) (or C(sp3)-Si) bonds via a Giese reaction.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We reported a one-pot photocyclization/ oxidation cascade of N-aryl acrylamides to afford quinoline-2-ones. Thioxanthone was used as a bifunctional energy transfer agent to mediate both photocyclization and generation of singlet oxygen, the latter facilitates the dehydrogenation of dihydroquinoline-2-one intermediate. This cascade strategy also supports the 5-endo-trig cyclization to synthesize tetrahydrocarbazolones from phenylamino cyclohexenones.
{"title":"Metal-free photocyclization/oxidation cascade constructing quinoline-2-ones and tetrahydrocarbazolones","authors":"Yanke Hao, He Huang","doi":"10.1002/adsc.202400525","DOIUrl":"https://doi.org/10.1002/adsc.202400525","url":null,"abstract":"We reported a one-pot photocyclization/ oxidation cascade of N-aryl acrylamides to afford quinoline-2-ones. Thioxanthone was used as a bifunctional energy transfer agent to mediate both photocyclization and generation of singlet oxygen, the latter facilitates the dehydrogenation of dihydroquinoline-2-one intermediate. This cascade strategy also supports the 5-endo-trig cyclization to synthesize tetrahydrocarbazolones from phenylamino cyclohexenones.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A palladium-catalyzed [4+4] cycloaddition of aryl-substituted γ-methylidene-δ-valerolactones (GMDVs) with divinylke-tones (DVKs) was developed, providing an approach to access various mono-cyclic tetrahydro-2H-oxocines with diverse substituents in up to 95% yields and >20:1 dr. This reaction was facilitated by anchoring olefin (C=C) at the α-position of carbonyls.
{"title":"Neighboring π-Coordination in Palladium Catalyzed [4+4] Cycloaddition of γ-Methylidene-δ-Valerolactones with Divinylketones","authors":"Xiaoying Wu, Wei Feng, Jiayi Zhao, Daoshan Yang, Ran Song, Wen Si, Jian Lv","doi":"10.1002/adsc.202400234","DOIUrl":"https://doi.org/10.1002/adsc.202400234","url":null,"abstract":"A palladium-catalyzed [4+4] cycloaddition of aryl-substituted γ-methylidene-δ-valerolactones (GMDVs) with divinylke-tones (DVKs) was developed, providing an approach to access various mono-cyclic tetrahydro-2H-oxocines with diverse substituents in up to 95% yields and >20:1 dr. This reaction was facilitated by anchoring olefin (C=C) at the α-position of carbonyls.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A synthesis of acyl halides from the corresponding carboxylic acid thioesters was achieved using commercially available Selectfluor or NCS, and the acyl fluoride or chloride intermediates were transformed to the corresponding esters, amides, and several carbon-carbon bond formation products. This approach can be applied to the peptide synthesis from functionalized amino acid thioesters.
{"title":"Synthesis of Acyl Halides from Carboxylic Acid Thioesters for Synthesis of Ketones, Esters, Amides and Peptides","authors":"Shuji Nagano, Keiji Maruoka","doi":"10.1002/adsc.202400531","DOIUrl":"https://doi.org/10.1002/adsc.202400531","url":null,"abstract":"A synthesis of acyl halides from the corresponding carboxylic acid thioesters was achieved using commercially available Selectfluor or NCS, and the acyl fluoride or chloride intermediates were transformed to the corresponding esters, amides, and several carbon-carbon bond formation products. This approach can be applied to the peptide synthesis from functionalized amino acid thioesters.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A copper catalyzed aerobic formal addition of aliphatic C(sp3)–H bonds to alkenes via a phenyl radical mediated intermolecular HAT process is reported herein, in which the phenylhydrazine not only acts as a good HAT reagent precursor but also as an excellent hydrogen atom donor. This reaction affords an alternative method for the direct formal addition of the aliphatic C(sp3)–H bonds to alkenes utilizing air as the radical initiator without additional reductants at the ambient temperature. A variety of alkanes and electron‐deficient alkenes are successfully incorporated, furnishing a series of aliphatic C(sp3)–H formal addition products in 20‐93% yields. The preliminary mechanistic studies uncover that the 2‐tetrahydrofuranyl and phenyl radical are formed in this reaction.
本文报告了一种铜催化的脂肪族 C(sp3)-H 键与烯烃通过苯基自由基介导的分子间 HAT 过程进行有氧形式加成的方法，其中苯肼不仅是一种良好的 HAT 试剂前体，还是一种极佳的氢原子供体。该反应提供了一种替代方法，利用空气作为自由基引发剂，在环境温度下无需额外的还原剂，即可直接将脂肪族 C(sp3)-H 键与烯烃进行形式加成。多种烷烃和缺电子烯烃被成功加入，生成了一系列脂肪族 C(sp3)-H 形式加成产物，产率为 20-93%。初步机理研究发现，在该反应中形成了 2-四氢呋喃基和苯基自由基。
{"title":"Cu‐catalyzed Formal Addition of Aliphatic C(sp3)–H Bonds to Alkenes via Phenyl Radical Involved Intermolecular HAT","authors":"Peizhi Bai, Xin Zhang, Qinshuang Su, Tiebo Xiao, Yubo Jiang, Guoying Zhang, Yinjun Xie, Guiping Qin","doi":"10.1002/adsc.202400377","DOIUrl":"https://doi.org/10.1002/adsc.202400377","url":null,"abstract":"A copper catalyzed aerobic formal addition of aliphatic C(sp3)–H bonds to alkenes via a phenyl radical mediated intermolecular HAT process is reported herein, in which the phenylhydrazine not only acts as a good HAT reagent precursor but also as an excellent hydrogen atom donor. This reaction affords an alternative method for the direct formal addition of the aliphatic C(sp3)–H bonds to alkenes utilizing air as the radical initiator without additional reductants at the ambient temperature. A variety of alkanes and electron‐deficient alkenes are successfully incorporated, furnishing a series of aliphatic C(sp3)–H formal addition products in 20‐93% yields. The preliminary mechanistic studies uncover that the 2‐tetrahydrofuranyl and phenyl radical are formed in this reaction.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141730607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The biocatalytic oxidative deamination‐ reductive amination process for the production of L‐phosphinothricin (L‐PPT) from D,L‐phosphinothricin (D,L‐PPT) is a green and environmentally friendly approach with significant development potential. In this study, the adopted technological route involves the oxidative deamination of the D‐PPT component in D,L‐PPT to 2‐oxo‐4‐(hydroxymethylphosphinyl)butanoic acid (PPO) by utilizing D‐amino acid oxidase (DAAO), fol‐lowed by the catalytic reductive amination of PPO to L‐PPT using phosphinothricin dehydrogenase (PpDH). In order to enhance the catalytic rate and reduce the inhibitory effect of the intermediate product PPO on the catalytic process, optimization of both oxidative deamination and reductive amination phases was conducted through separate strategies of constant‐pressure oxygen supply and substrate feeding, respectively. A "two‐step one‐pot" method was employed to link the optimized reactions, significantly shortening the production time. Furthermore, the "two‐step one‐pot" catalytic strategy was optimized, ultimately achieving a high 97.7% yield of L‐PPT with ee of L‐PPT ＞99.9% after 5.5 h of reaction under 800 mM D,L‐PPT catalytic conditions,further enchanced the catalytic efficiency and product yield.The aforementioned results demonstrate that this proposed approach has great potential for industrial‐scale production of L‐PPT as well as significant competitive advantages in terms of economic feasibility.
{"title":"Enzyme Cascade with Four Enzymes in One Pot for the Synthesis of L‐Phosphinothricin","authors":"jianmiao xu, Zhijie Xi, Keji Keji Zhao, Chenxiang He, Feng Cheng, Ya-Ping Xue, Yu-Guo Zheng","doi":"10.1002/adsc.202400498","DOIUrl":"https://doi.org/10.1002/adsc.202400498","url":null,"abstract":"The biocatalytic oxidative deamination‐ reductive amination process for the production of L‐phosphinothricin (L‐PPT) from D,L‐phosphinothricin (D,L‐PPT) is a green and environmentally friendly approach with significant development potential. In this study, the adopted technological route involves the oxidative deamination of the D‐PPT component in D,L‐PPT to 2‐oxo‐4‐(hydroxymethylphosphinyl)butanoic acid (PPO) by utilizing D‐amino acid oxidase (DAAO), fol‐lowed by the catalytic reductive amination of PPO to L‐PPT using phosphinothricin dehydrogenase (PpDH). In order to enhance the catalytic rate and reduce the inhibitory effect of the intermediate product PPO on the catalytic process, optimization of both oxidative deamination and reductive amination phases was conducted through separate strategies of constant‐pressure oxygen supply and substrate feeding, respectively. A \"two‐step one‐pot\" method was employed to link the optimized reactions, significantly shortening the production time. Furthermore, the \"two‐step one‐pot\" catalytic strategy was optimized, ultimately achieving a high 97.7% yield of L‐PPT with ee of L‐PPT ＞99.9% after 5.5 h of reaction under 800 mM D,L‐PPT catalytic conditions,further enchanced the catalytic efficiency and product yield.The aforementioned results demonstrate that this proposed approach has great potential for industrial‐scale production of L‐PPT as well as significant competitive advantages in terms of economic feasibility.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":null,"pages":null},"PeriodicalIF":5.4,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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