{"title":"Molecular Profile of Cutaneous Melanoma","authors":"N. Mazurenko","doi":"10.14744/ejmo.2022.34002","DOIUrl":"https://doi.org/10.14744/ejmo.2022.34002","url":null,"abstract":"DOI: 10.14744/ejmo.2022.34002 EJMO 2022;6(1):43–49 Eurasian Journal of Medicine and Oncology","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74265866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2022.17217
M. Rouhani
nu-Objectives: Breast cancer shows the highest incidence and cancer-related deaths among women worldwide. Radiotherapy is used for treating different stages of breast cancer. Several polyphenols have increased the effectiveness of radiotherapy. Wogonin is a flavone compound abundant in the root of Chinese skullcap. This compound induced apoptosis and inhibited proliferation distinctively in cancer cells. We studied effect of wogonin on the response of a typical breast cancer cell line to ionizing radiation. Methods: MCF-7 cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell counting and double staining apoptosis assays were also used to find suitable physiologically relevant concentrations of wogonin. Cells treated with wogonin were exposed to different doses of X-ray and clonogenic survival assay was utilized to determine the effect of wogonin on survival from radiation. Results: Wogonin treatment decreased the viability of MCF-7 cells in a dose- and time-dependent manner. It decreased number of cells and increased percent of apoptotic cells dose dependently. Cells pretreated with 5 and 10 µM concentrations of wogonin 3 days before radiation showed increased radioresistance compared with cells that were not treated with wogonin. Conclusion: Treatment of MCF-7 breast cancer cells with wogonin made them more resistant to ionizing radiation.
{"title":"Wogonin from Scutellaria baicalensis-Induced Radioresistance in MCF-7 Breast Cancer Cell Line","authors":"M. Rouhani","doi":"10.14744/ejmo.2022.17217","DOIUrl":"https://doi.org/10.14744/ejmo.2022.17217","url":null,"abstract":"nu-Objectives: Breast cancer shows the highest incidence and cancer-related deaths among women worldwide. Radiotherapy is used for treating different stages of breast cancer. Several polyphenols have increased the effectiveness of radiotherapy. Wogonin is a flavone compound abundant in the root of Chinese skullcap. This compound induced apoptosis and inhibited proliferation distinctively in cancer cells. We studied effect of wogonin on the response of a typical breast cancer cell line to ionizing radiation. Methods: MCF-7 cell viability was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Cell counting and double staining apoptosis assays were also used to find suitable physiologically relevant concentrations of wogonin. Cells treated with wogonin were exposed to different doses of X-ray and clonogenic survival assay was utilized to determine the effect of wogonin on survival from radiation. Results: Wogonin treatment decreased the viability of MCF-7 cells in a dose- and time-dependent manner. It decreased number of cells and increased percent of apoptotic cells dose dependently. Cells pretreated with 5 and 10 µM concentrations of wogonin 3 days before radiation showed increased radioresistance compared with cells that were not treated with wogonin. Conclusion: Treatment of MCF-7 breast cancer cells with wogonin made them more resistant to ionizing radiation.","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77980264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2022.50386
alfredo colombo
percentage
百分比
{"title":"Immunotherapy in Elderly Patients: A Review","authors":"alfredo colombo","doi":"10.14744/ejmo.2022.50386","DOIUrl":"https://doi.org/10.14744/ejmo.2022.50386","url":null,"abstract":"percentage","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87043319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2023.41870
Javaria Isram
,
，
{"title":"Predictors of Hepatic Decompensation after TACE for Hepatocellular Carcinoma Secondary to Chronic Hepatitis C","authors":"Javaria Isram","doi":"10.14744/ejmo.2023.41870","DOIUrl":"https://doi.org/10.14744/ejmo.2023.41870","url":null,"abstract":",","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"23 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90757964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
While humanity has not been able to end the fight against the COVID-19 pandemic, newly reported cases of monkey-pox have caused unease.The current review sheds light on the transmission routes, pathogenesis, clinical presentation, treatment, and prevention of the disease in this early stage of the ongoing monkeypox epidemic.
{"title":"Another Epidemic in the Shadow of Covid 19 Pandemic: A Review of Monkeypox","authors":"R. A. Okyay","doi":"10.14744/ejmo.2022.2022","DOIUrl":"https://doi.org/10.14744/ejmo.2022.2022","url":null,"abstract":"While humanity has not been able to end the fight against the COVID-19 pandemic, newly reported cases of monkey-pox have caused unease.The current review sheds light on the transmission routes, pathogenesis, clinical presentation, treatment, and prevention of the disease in this early stage of the ongoing monkeypox epidemic.","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86064026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2022.39682
J. S. Chaleshtori
Objectives: This simulated study has mechanistically evaluated the molecular dynamics effects of rutin on CDKs 2, 4, and 6 in cell cycling. Methods: Protein Data Bank (http://www.rcsb.org) was used to obtain the PDB file of CDK 2, 4, and 6. After simulation of CDKs in Gromacs software, AutoDock 4.2 was used to run 200 stages of molecular docking of CDKs in the presence of the rutin. CDK 2, 4, and 6 were simulated in the presence of rutin after docking. Results: Rutin had the highest tendency to bind the CDK-2 and CDK-6 via binding 16 and 18 residues in the binding site with hydrogen and hydrophobic bonds (respectively). Also, they had the highest amount of binding energy released. Rutin decreased total energy in CDKs and reduced the radius of gyration in CDK-2 and CDK-6 after docking. The secondary coil structure increased in CDK-2 and decreased in CDK-4 and 6. Conclusion: Conformational changes in CDK2 and 6 via rutin can inhibit the activity of these proteins and subsequent-ly arrest the cell cycle in phases G1, S, and G2, which can lead the damaged cell to cell repair or Apoptosis. Abstract Article:
{"title":"The Molecular Dynamics Effects of Rutin on CDKS 2, 4 and 6: In Silico Modelling and Molecular Dynamics","authors":"J. S. Chaleshtori","doi":"10.14744/ejmo.2022.39682","DOIUrl":"https://doi.org/10.14744/ejmo.2022.39682","url":null,"abstract":"Objectives: This simulated study has mechanistically evaluated the molecular dynamics effects of rutin on CDKs 2, 4, and 6 in cell cycling. Methods: Protein Data Bank (http://www.rcsb.org) was used to obtain the PDB file of CDK 2, 4, and 6. After simulation of CDKs in Gromacs software, AutoDock 4.2 was used to run 200 stages of molecular docking of CDKs in the presence of the rutin. CDK 2, 4, and 6 were simulated in the presence of rutin after docking. Results: Rutin had the highest tendency to bind the CDK-2 and CDK-6 via binding 16 and 18 residues in the binding site with hydrogen and hydrophobic bonds (respectively). Also, they had the highest amount of binding energy released. Rutin decreased total energy in CDKs and reduced the radius of gyration in CDK-2 and CDK-6 after docking. The secondary coil structure increased in CDK-2 and decreased in CDK-4 and 6. Conclusion: Conformational changes in CDK2 and 6 via rutin can inhibit the activity of these proteins and subsequent-ly arrest the cell cycle in phases G1, S, and G2, which can lead the damaged cell to cell repair or Apoptosis. Abstract Article:","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81858596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effects of a Health Literacy Training Intervention on Self-Care Behaviors and Treatment Adherence in Patients with Ischemic Heart Diseases","authors":"Zeynab Hakimzadeh","doi":"10.14744/ejmo.2021.61673","DOIUrl":"https://doi.org/10.14744/ejmo.2021.61673","url":null,"abstract":"DOI: 10.14744/ejmo.2021.61673 EJMO 2021;5(4):341–349","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85947911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Metformin Eliminates CD133high/CD44high Prostate Cancer Stem Cells Via Cell Cycle Arrest and Apoptosis","authors":"Eda Acikgoz, M. Cakir, Mustafa Güven, G. Oktem","doi":"10.14744/ejmo.2021.11927","DOIUrl":"https://doi.org/10.14744/ejmo.2021.11927","url":null,"abstract":"DOI: 10.14744/ejmo.2021.11927 EJMO 2021;5(4):298–304","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89497803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-01DOI: 10.14744/ejmo.2022.50709
J. Yakisich
{"title":"Downregulation of DKK-1 and Upregulation of B - Catenin in Cancer Floating Spheroids is Associated with Chemoresistance to Wnt Signaling Pathway Inhibitors","authors":"J. Yakisich","doi":"10.14744/ejmo.2022.50709","DOIUrl":"https://doi.org/10.14744/ejmo.2022.50709","url":null,"abstract":"","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89757626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structure-based molecular docking studies towards exploring phytoestrogen against breast cancer","authors":"M. Sankaran","doi":"10.14744/ejmo.2022.43656","DOIUrl":"https://doi.org/10.14744/ejmo.2022.43656","url":null,"abstract":"DOI: 10.14744/ejmo.2022.43656 EJMO 2022;6(2):142–149","PeriodicalId":11831,"journal":{"name":"Eurasian Journal of Medicine and Oncology","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77036431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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