Epilepsy & Behavior最新文献

{"title":"Digital screen exposure and sleep disorders in children with epilepsy: The impact of sociodemographic, clinical, and individual factors","authors":"Gül Yücel ,&nbsp;Ahmet Kadir Arslan ,&nbsp;Işınsu Bıçakcıoğlu ,&nbsp;Nur Yücel Ekici ,&nbsp;Bilge Özgör","doi":"10.1016/j.yebeh.2026.110917","DOIUrl":"10.1016/j.yebeh.2026.110917","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study is to determine the relationship between daily digital screen exposure and sleep disorders in children with epilepsy (CWE), focusing on different sleep subdomains. In addition, the possible regulatory role of socio-demographic factors and individual chronotype characteristics affecting digital screen exposure was also evaluated.</div></div><div><h3>Methods</h3><div>This cross-sectional analytical study included 132 CWE and their mothers. Data were collected using sociodemographic/clinical forms, the Sleep Disturbances Scale for Children (SDSC), the Pittsburgh Sleep Quality Index (PSQI), and the Children’s Chronotype Questionnaire (CCQ). Digital screen exposure was assessed using a parent-reported form; daily exposure was calculated by taking the weighted average of weekday and weekend usage times.</div></div><div><h3>Results</h3><div>The study found a significant, positive correlation between average digital screen exposure time and total SDSC score (rho = 0.23; p = 0.008). This association was particularly evident in the subdomains of disorders of initiating and maintaining sleep (DIMS), disorders of excessive somnolence (DOES), and sleep-<strong>-</strong>related breathing disorders (SDB). Socio-demographically, maternal education level significantly affected digital screen exposure; children of mothers with a university degree had statistically lower digital screen exposure (p = 0.001). While total digital screen exposure did not differ by chronotype, a stronger positive correlation between digital screen exposure and the SDB subdomain was observed in children with an evening chronotype (rho = 0.363; p = 0.045).</div></div><div><h3>Conclusion</h3><div>These findings indicate that increased digital screen exposure significantly, but only weakly/moderately, associated with increased the severity of sleep disorders in CWE. Maternal education level and individual chronotype differences play a critical role in managing this negative relationship and identifying at-risk groups. Clinicians should develop personalized intervention programs regarding digital screen exposure, particularly for families with children who have low educational levels and are biologically at risk (evening chronotype).</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110917"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delay to diagnosis of epilepsy: A history of a psychiatric disorder and substance use is associated with prior seizures","authors":"Honor Coleman ,&nbsp;Genevieve Rayner ,&nbsp;K.Meng Tan ,&nbsp;Patrick W. Carney ,&nbsp;Piero Perucca ,&nbsp;Patrick Kwan ,&nbsp;Terence J. O’Brien ,&nbsp;Samuel F. Berkovic ,&nbsp;Anne M. McIntosh","doi":"10.1016/j.yebeh.2025.110864","DOIUrl":"10.1016/j.yebeh.2025.110864","url":null,"abstract":"<div><h3>Objective</h3><div>A substantial proportion of patients with newly diagnosed epilepsy report prior seizures, however little is known about risks for this delay to diagnosis. Here, we examined whether pre-existing alcohol/substance use or psychiatric disorders are associated with prior seizures before a diagnosis of epilepsy or unprovoked seizures.</div></div><div><h3>Methods</h3><div>Included were 1,383 adults who attended First Seizure Clinics (FSCs) at Austin Hospital or Royal Melbourne Hospital, Australia, between 2000 and 2010 who were diagnosed with epilepsy or unprovoked seizures. Data were audited from routine epileptologist assessments. Patients with ≥ 1 seizure before their index seizure were coded positive for prior seizures, excluding acute symptomatic seizures. We compared a history of prior seizures in patients with pre-existing psychiatric disorders and/or substance use (including alcohol) to patients without these conditions using logistic regression analyses.</div></div><div><h3>Results</h3><div>Prior seizures were reported by 37 % (n = 515) of patients. Amongst patients with both substance use and psychiatric conditions, 50 % (31/62) had prior seizures (adjusted OR [aOR] 2.0, 95 %CI 1.2–3.4, p = 0.01 compared with patients with neither condition). Prior seizures occurred in 41 % (68/165) of patients with substance use only (aOR 1.37, 95 %CI 0.96–1.9, p = 0.08), and 34 % (64/187) of those with a psychiatric diagnosis only (aOR 0.93, 95 %CI 0.7–1.3, p = 0.67). Amongst those who were negative for both conditions, 36 % (352/969) had prior seizures.</div></div><div><h3>Significance</h3><div>Individuals with a history of both substance use and psychiatric disorders are at risk of delays to specialist epilepsy diagnosis. Screening for prior seizures in patients with these disorders would facilitate informed treatment decisions.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110864"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical study on glymphatic system dysfunction in patients with temporal lobe epilepsy","authors":"Yueer Qiu ,&nbsp;Yamei Lin ,&nbsp;Nuozhen Chen ,&nbsp;Yaling Chen ,&nbsp;Kanlin Lin ,&nbsp;Xiaoyang Wang ,&nbsp;Shangwen Xu","doi":"10.1016/j.yebeh.2026.110909","DOIUrl":"10.1016/j.yebeh.2026.110909","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate glymphatic system (GS) dysfunction in patients with unilateral temporal lobe epilepsy (TLE) based on the coupling of global blood-oxygen-level-dependent (gBOLD) signals and cerebrospinal fluid (CSF) inflow, as well as choroid plexus (CP) volume.</div></div><div><h3>Methods</h3><div>This retrospective study included 64 unilateral TLE patients and 40 age- and sex-matched healthy controls (HC). gBOLD-CSF coupling strength and CP volume were measured in all participants. Patients were grouped by epileptogenic zone into left temporal lobe epilepsy (LTLE) and right temporal lobe epilepsy (RTLE) groups; and by postsurgical outcome into good outcome (GO) and poor outcome (PO) groups. Group differences in gBOLD-CSF coupling and CP volume were compared, and their correlations with clinical characteristics and structural metrics (including total intracranial volume [TIV], cortical gray matter volume [CGMV], and lateral ventricular volume [LVV]) were analyzed. Additionally, univariate and multivariate logistic regression analyses were conducted to construct predictive models for postsurgical seizure outcomes.</div></div><div><h3>Results</h3><div>TLE patients showed significantly weaker gBOLD-CSF coupling and larger CP volume than the HC group. gBOLD-CSF coupling was reduced in both GO and PO groups compared with the HC group. LTLE patients exhibited significantly weaker gBOLD-CSF coupling than the HC group. CP volume was significantly larger in the PO group than in both the HC and GO groups, with no significant differences among the LTLE, RTLE, and HC groups. gBOLD-CSF coupling correlated negatively with CGMV/TIV, while CP volume correlated negatively with CGMV/TIV and positively with ventricular indices. Notably, CP volume was an independent predictor of postsurgical outcome. The combined model (CGMV/TIV + history of febrile seizures + CPV/TIV) yielded an area under the curve (AUC) of 0.799 for predicting postsurgical outcome.</div></div><div><h3>Conclusion</h3><div>Patients with TLE exhibit significant GS dysfunction associated with cerebral atrophy. CP volume represents an independent predictor of postsurgical outcome. Furthermore, the combined model (CGMV/TIV + history of febrile seizures + CPV/TIV) demonstrates strong predictive value for postsurgical outcome.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110909"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are symptoms clustered into latent classes in pediatric functional neurological disorder?","authors":"Akihiro Nishi ,&nbsp;Itaru Hayakawa ,&nbsp;Yusuke Okubo ,&nbsp;Jeff L. Waugh ,&nbsp;Hiroki Nariai","doi":"10.1016/j.yebeh.2025.110876","DOIUrl":"10.1016/j.yebeh.2025.110876","url":null,"abstract":"<div><h3>Objective</h3><div>DSM-5-TR and ICD-11 classify functional/dissociative seizures (FDS, formerly known as psychogenic nonepileptic seizures [PNES]) and functional movement disorder (FMD) under the broad category of functional neurological disorder (FND). However, substantial heterogeneity within FND has led some to hypothesize that FDS and FMD may represent distinct disease entities. To test this hypothesis, we aimed to determine whether the variation in FND symptoms among pediatric patients is best explained by either a single disease entity or two or more distinct disease entities.</div></div><div><h3>Methods</h3><div>We analyzed data from 155 Australian children and adolescents with FND who were recruited between 2006 and 2023 and who had one or more symptoms across four categories: negative motor symptoms (e.g., limb weakness), positive motor symptoms (e.g., tremor), sensory deficit symptoms (e.g., loss of touch), and functional seizures. We performed latent class analysis (LCA) with binary indicators (e.g., symptom present/absent in each category) to identify latent classes (subgroups) based on non-random patterns in symptom co-occurrence.</div></div><div><h3>Results</h3><div>LCA supported a two-class model rather than a single-class, three-class, or four-class model. The Bayesian Information Criterion (BIC) was lowest for the two-class model (839.2), compared with 866.2 for the single-class model, 850.9 for the three-class model, and 871.3 for the four-class model. In the optimal two-class solution, the first class (70.7 % of the sample) frequently exhibits negative motor symptoms (76.2 %) as well as positive motor symptoms (64.3%), along with occasional functional seizures (37.9 %) and sensory deficit symptoms (49.3%). The second class (29.3 % of the sample) is characterized by functional seizures in all cases (100 %), occasional sensory deficit symptoms (10.9 %) and positive motor symptoms (29.9 %), with almost no negative motor symptoms (1.1 %).</div></div><div><h3>Conclusion</h3><div>Our latent class analysis of symptom profiles suggests that the Australian pediatric FND cohort is best explained by a two-class model, in which the two classes have a substantial overlap and can produce the same set of symptoms.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110876"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features associated with a response to ethosuximide in developmental and epileptic encephalopathy with spike wave activation in sleep","authors":"Andy Cheuk-Him Ng ,&nbsp;Vineetha Warriyar K.V ,&nbsp;Sabrina D’Alfonso ,&nbsp;Morris H. Scantlebury","doi":"10.1016/j.yebeh.2025.110866","DOIUrl":"10.1016/j.yebeh.2025.110866","url":null,"abstract":"<div><div>Developmental and epileptic encephalopathy with spike-wave activation in sleep (D)EE-SWAS is characterized by a marked increase in epileptiform activity during non-REM sleep. This increase in sleep-related epileptic activity disturbs normal sleep architecture and leads to a stagnation and regression in various behavior and neurocognitive domains. Ethosuximide (ETX) targets T-type calcium channel in the thalamus, an area involved in the generation of sleep potentials and sleep-activated spikes, and as such, ETX had been tried in the past for (D)EE-SWAS. In this retrospective study, we reviewed our database for patients with (D)EE-SWAS-spectrum disorders treated with ETX. Among patients treated with ETX as an add-on therapy, 43.5% (10/23) achieved an absolute decrease in spike-wave index (SWI%) of 25 or more (ETX responder) at the first follow-up EEG compared to baseline; whereas 57.1% (12/21) were ETX responders at the second follow-up EEG. Statistical testing showed that ETX responder status was significantly associated with several clinical factors, including underlying etiology, focal interictal epileptiform discharges, and epilepsy syndrome. A trend towards an association of ETX responder and normal MRI was seen but did not reach statistical significance. Overall, our data supports the use of ETX in (D)EE-SWAS, and that it is possible to predict ETX responders based on clinical factors.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110866"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the psychological impact on parents of learning about SUDEP? A mixed methods systematic review","authors":"Siobhan Kiely ,&nbsp;Anthony Mercier ,&nbsp;Joseph D Symonds ,&nbsp;Liam Dorris","doi":"10.1016/j.yebeh.2026.110915","DOIUrl":"10.1016/j.yebeh.2026.110915","url":null,"abstract":"<div><h3>Background</h3><div>We conducted a systematic review of the literature on parent responses to learning about Sudden Unexpected Death in Epilepsy (SUDEP) including cognitions/appraisals, emotions, and changes to parenting behaviour for their child with epilepsy.</div></div><div><h3>Methods</h3><div>A mixed methods systematic review approach was taken using guidance from the Joanna Briggs Institute (JBI). EMBASE, MEDLINE, PsycARTICLES, PsycINFO, and PubMed were searched. Risk of bias was assessed using Critical appraisal tools from the JBI. A total of 9 studies (4 qualitative and 5 quantitative) were included in the review with 677 participants.</div></div><div><h3>Results</h3><div>Parents want to know about SUDEP and prefer this information to come from their child’s treating physician. They value time to process information and to follow-up with a healthcare professional. Parents want to be signposted to relevant organisations and sources of support. Parents report feeling anxious or stressed on learning about SUDEP. They can feel angry in cases when they had not been told. Parents report that the advantages of knowing about SUDEP outweigh the disadvantages. Parents report making changes to caregiving after learning about SUDEP including increased monitoring and supervision, increased compliance with medication, and increased information sharing with others. There was significant heterogeneity in included studies in terms of samples and methodology with a moderate to high risk of bias meaning caution is required when interpreting findings.</div></div><div><h3>Conclusions</h3><div>The majority of parents want information on SUDEP despite finding the information distressing. Parents use SUDEP information to adjust their caregiving e.g. increasing monitoring and supervision or communicating relevant information about their child’s epilepsy to others e.g. their child’s school. Clinicians play a key role in identifying and supporting the re-appraisal of unhelpful or inaccurate beliefs around SUDEP and can mitigate distress associated with receiving information on SUDEP with clear and supportive communication.</div><div>This review is registered on PROSPERO (Registration: CRD42024546466).</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110915"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cenobamate beyond Epilepsy: exploring associations with vascular risk factors through serological markers","authors":"Anthony D Jimenez ,&nbsp;Xin Zhou ,&nbsp;Nikol Agadzhanian ,&nbsp;Aurelie Hanin ,&nbsp;Isabel Toghramadjian ,&nbsp;Chinenye M Okafor ,&nbsp;Poojith Nuthalapati ,&nbsp;Jayanth Tallapalli ,&nbsp;Sagune Sakya ,&nbsp;Anuradha Singh ,&nbsp;Hamada H Altalib ,&nbsp;Richard Mattson ,&nbsp;Mark Howard Schoenfeld ,&nbsp;Aline Herlopian","doi":"10.1016/j.yebeh.2026.110890","DOIUrl":"10.1016/j.yebeh.2026.110890","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Anti-seizure medications (ASM) variably affect cardiovascular and cerebrovascular risk factors, as evidenced by changes in associated serological biomarkers. While enzyme-inducing ASM vascular effects are well studied, those of cenobamate (CNB) remain unknown. We examined CNB’s impact on vascular risk by analyzing longitudinal changes in these biomarkers, addressing an important knowledge gap as CNB use expands in epilepsy management.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of adults (≥18 years) receiving CNB with ≥ 3 serial biomarker measurements (either 2 pre-/1 post-CNB or 1 pre-/2 post-CNB). Analyzed biomarkers comprised glycosylated hemoglobin (HbA1c), international normalized ratio (INR), and the lipid profile consisting of low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), triglycerides (TG), and total cholesterol (TC).</div></div><div><h3>Results</h3><div>Among 413 patients receiving CNB, 96 patients met inclusion criteria (56 HbA1c, 50 lipid profile analysis, 21 INR). HbA1c increased significantly by 0.24 % post-CNB (p = 0.017), with greater increases in patients with diabetes mellitus (DM) (0.48 % vs. 0.09 % in non-diabetics, p &lt; 0.001). Insulin use was associated with a further HbA1c rise (0.61 %increase, p=&lt;0.001). Lipid profile changes showed an overall non-significant increase (HDL-c + 0.44 mg/dL, LDL-c + 6.99 mg/dL, TC + 8.84 mg/dL, and TG + 7.68 mg/dL), though statins attenuated these effects. Significant dose-dependent changes were observed for LDL-c and TC (p(Dose) = 0.007–0.012; p(statin) = 0.008–0.009). HDL-c increased non-significantly by 0.96 mg/dL per 100 mg of CNB without statins but decreased by 0.35 mg/dL per 100 mg of CNB with statins. TG levels rose modestly regardless of statin use. INR increased non-significantly (+0.05-point, p = 0.609) post-CNB, without any dose-dependent effect within the anticoagulant (AntiCOAG) users and non-users. Anticoagulant use was barely significantly associated with higher post-CNB INR values<!--> <!-->(p (AntiCOAG) = 0.043).</div></div><div><h3>Discussion</h3><div>While this retrospective study has inherent limitations, our results indicate potential CNB-associated changes in metabolic biomarkers. Definitive evaluation of CNB’s vascular effects will require prospective, controlled, multicenter studies that integrate serial biomarker monitoring with clinical endpoints and adjusting for concomitant ASM use, particularly enzyme-inducing agents.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110890"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spike-Hyperslow-Wave (SHsW) complex: a distinctive ictal EEG hallmark of myoclonic-atonic seizures in EMAtS","authors":"Lucia Fusco","doi":"10.1016/j.yebeh.2025.110874","DOIUrl":"10.1016/j.yebeh.2025.110874","url":null,"abstract":"","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110874"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the cognitive-motor performance of individuals with temporal lobe epilepsy versus healthy controls using robotics","authors":"Kristen Kyone ,&nbsp;Spencer Finn ,&nbsp;Theodore S. Aliyianis ,&nbsp;Brooke C. Beattie ,&nbsp;Adam Falah ,&nbsp;Lysa Boissé Lomax ,&nbsp;Garima Shukla ,&nbsp;Christopher Hlynialuk ,&nbsp;Stephen H. Scott ,&nbsp;Gavin P. Winston","doi":"10.1016/j.yebeh.2025.110877","DOIUrl":"10.1016/j.yebeh.2025.110877","url":null,"abstract":"<div><div>Cognitive impairments are common in individuals with temporal lobe epilepsy (TLE). Interactive Kinarm robotic systems provide a novel approach to quantify cognitive impairment. The Object Hit and Avoid (OHA) and Reverse Visually Guided Reaching (RVGR) tasks examine higher order neurocognitive domains (executive function, attention, visuospatial function). This study explores differences in OHA and RVGR performance between patients with TLE and healthy controls, and measures their sensitivity to impairment. Participants completed the Kinarm assessment. Task parameter performance quantifying different aspects of cognitive-motor skills were analyzed using one-sample t-tests and Wilcoxon signed rank tests, with false discovery rate corrections. The parameters with the greatest sensitivity identified up to 21 % (OHA) and 37 % (RVGR) of patients (n = 70) as impaired. Patients performed worse on some OHA parameters compared to normative controls, with fewer target hits, more distractor hits, fewer object hits, lower median error, and slower object processing rates. No differences were found in OHA inter-limb coordination. Patients performed worse on some RVGR parameters, showing slower reaction times, less coordinated initial movement, and altered speed-based parameters. Patients with TLE showed significant impairment in accuracy and cognitive processing speed on Kinarm tasks, with preserved basic motor function and bimanual coordination. Influence of clinical variables including laterality, duration of epilepsy, age of first seizure were minimal. This shows the ability of the Kinarm robot to detect the nature of cognitive-motor deficits in TLE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110877"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between catamenial epilepsy and seizure frequency during pregnancy","authors":"Emma C. Osterhaus ,&nbsp;Jacqueline A. French ,&nbsp;Rishabh Jain ,&nbsp;Wesley T. Kerr ,&nbsp;Page B. Pennell","doi":"10.1016/j.yebeh.2025.110830","DOIUrl":"10.1016/j.yebeh.2025.110830","url":null,"abstract":"<div><h3>Objective</h3><div>To compare seizure outcomes during pregnancy in women with epilepsy (WWE) by history of catamenial patterns.</div></div><div><h3>Background</h3><div>Catamenial patterns are defined as increased seizure frequency during certain phases of the menstrual cycle (perimenstrual, peri-ovulatory, or luteal in anovulatory cycles). Animal studies suggest seizure improvement occurs with higher progesterone and allopregnanolone concentrations and lower estrogen concentrations. Prior human studies also reported that WWE with catamenial patterns were more likely to have improved seizure frequency during pregnancy, presumably due to higher sensitivity to fluctuations in sex steroid hormones.</div></div><div><h3>Design/methods</h3><div>Women with epilepsy (WWE), ages 18–40yo, were enrolled in a longitudinal, prospective cohort study at time of attempting conception to compare fertility outcomes to healthy controls. Once enrolled, WWE used a daily diary app for menstrual and seizure tracking from preconception through delivery. For this secondary analysis, participants were excluded if they chose to discontinue the study, if they did not become pregnant, were seizure free preconception, if their diary data was inadequate (defined as &lt;80 % of the days tracked), or if they had &lt;1 month of seizure data tracked prior to conception. Prospective diary data was used to determine if participants met criteria for observed catamenial patterns. Seizure frequency during pregnancy was compared to preconception frequency.</div></div><div><h3>Results</h3><div>Among 89 participants, 13 became pregnant with seizure tracking; 6 (46 %) met criteria for catamenial epilepsy. Focal epilepsy was less common than generalized epilepsy in the catamenial group (33 %) vs the non-catamenial group (86 %, p = 0.10). No significant differences in seizure frequency change from preconception to pregnancy were observed between groups (p = 0.42). During pregnancy, 33 % of the catamenial group and 43 % of the non-catamenial group became seizure-free (p = 0.99). Seizure improvement or stability occurred in 67 % and 86 %, respectively (p = 0.56).</div></div><div><h3>Conclusions</h3><div>In patients who had preconception seizures, seizure control during pregnancy was generally favorable: many patients’ seizure frequency improved or achieved seizure freedom. There was no clear evidence that a pre-conception catamenial pattern immediately before pregnancy altered prognosis. Further research is needed to guide counseling and treatment during pregnancy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110830"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}