Pub Date : 2025-02-26DOI: 10.1016/j.yebeh.2025.110332
Ann Hyslop , Marytery Fajardo
This is a summary of the three commercially available neuromodulation devices for refractory epilepsy, highlighting their use in children. The article offers a high-level review of the proposed mechanisms of vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation, the pivotal trials leading to their approval for use in the United States, as well as their efficacy and associated adverse effects.
{"title":"Neuromodulation in pediatric drug-resistant epilepsy","authors":"Ann Hyslop , Marytery Fajardo","doi":"10.1016/j.yebeh.2025.110332","DOIUrl":"10.1016/j.yebeh.2025.110332","url":null,"abstract":"<div><div>This is a summary of the three commercially available neuromodulation devices for refractory epilepsy, highlighting their use in children. The article offers a high-level review of the proposed mechanisms of vagus nerve stimulation, responsive neurostimulation, and deep brain stimulation, the pivotal trials leading to their approval for use in the United States, as well as their efficacy and associated adverse effects.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110332"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-26DOI: 10.1016/j.yebeh.2025.110343
Alaa Elmazny , Mona Hussein , Noha A. Abd ElMonem , Salsabil Abo Al-Azayem , Hazem Samy Matar , Zeinab Mohammed , Rehab Magdy
Background & objectives
No validated questionnaires exist to examine the public’s attitudes about epilepsy in Arabic in particular. Therefore, this study aimed to test the validity and reliability of the Arabic version of the Public Attitudes Toward Epilepsy (PATE) scale.
Methods
In this cross-sectional study, Egyptian Arabic-speaking adults aged >18 from different socioeconomic backgrounds were enrolled. To capture the factor structure of the items, exploratory factor analysis was performed using Equamax rotation with Kaiser Normalization. The reliability of the scale was tested by measuring Cronbach’s alpha.
Results
Five hundred sixty participants (205 males and 355 females) with a median age of 33 (25–41) years were enrolled. Cronbach’s alpha was 0.806 for the general domain, indicating excellent reliability, while it was 0.644 for the personal domain, indicating satisfactory reliability. No ceiling or floor effects were detected. Also, the correlation coefficients between each item and its corresponding domain were higher than that of the other domain or the total score. Exploratory factor analysis confirmed that items on the PATE scale were loaded on their two hypothesized domains.
Conclusion
The Arabic version of the PATE scale is a valid and reliable tool for assessing the attitudes toward epilepsy in Arabic-speaking populations.
{"title":"Psychometric properties of the Arabic version of the public attitudes toward epilepsy (PATE) scale","authors":"Alaa Elmazny , Mona Hussein , Noha A. Abd ElMonem , Salsabil Abo Al-Azayem , Hazem Samy Matar , Zeinab Mohammed , Rehab Magdy","doi":"10.1016/j.yebeh.2025.110343","DOIUrl":"10.1016/j.yebeh.2025.110343","url":null,"abstract":"<div><h3>Background & objectives</h3><div>No validated questionnaires exist to examine the public’s attitudes about epilepsy in Arabic in particular. Therefore, this study aimed to test the validity and reliability of the Arabic version of the Public Attitudes Toward Epilepsy (PATE) scale.</div></div><div><h3>Methods</h3><div>In this cross-sectional study, Egyptian Arabic-speaking adults aged >18 from different socioeconomic backgrounds were enrolled. To capture the factor structure of the items, exploratory factor analysis was performed using Equamax rotation with Kaiser Normalization. The reliability of the scale was tested by measuring Cronbach’s alpha.</div></div><div><h3>Results</h3><div>Five hundred sixty participants (205 males and 355 females) with a median age of 33 (25–41) years were enrolled. Cronbach’s alpha was 0.806 for the general domain, indicating excellent reliability, while it was 0.644 for the personal domain, indicating satisfactory reliability. No ceiling or floor effects were detected. Also, the correlation coefficients between each item and its corresponding domain were higher than that of the other domain or the total score. Exploratory factor analysis confirmed that items on the PATE scale were loaded on their two hypothesized domains.</div></div><div><h3>Conclusion</h3><div>The Arabic version of the PATE scale is a valid and reliable tool for assessing the attitudes toward epilepsy in Arabic-speaking populations.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110343"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
depression is a psychiatric disorder present in many chronic diseases with varying prevalences. In people with epilepsy (PWE), it represents the most frequent psychiatric comorbidity associated with impaired quality of life, and increased risk of suicide. The aim of this research was to determine the prevalence and factors associated with depression in PWE.
Methods
this was a cross-sectional study with an age- and sex- matched control group, conducted between February 12 and May 15, 2024, in two referral hospital of Douala. It included individuals (PWE and controls) aged 18 years and older who agreed to participate in the study. Individuals (PWE and controls) with a serious general health problem that could have a significant impact on mental status (hypertension, HIV, diabetes, renal failure, heart failure, dementia, bipolar disorder) or an inability to communicate were excluded. Recruitment was done through an online and in-person survey using a form. We collected sociodemographic data, and data on epilepsy in PWE. Depression was evaluated using the PHQ-9 scale. We used the Generalized Anxiety Disorder Questionnaire (GAD-7) to assess anxiety disorders. Univariate and multivariate analysis (binary logistic regression) were used to identify the factors significantly associated with depression in PWE. The significance threshold was considered for a value of p < 0.05.
Results
a total of 633 individuals, including 211 PWE, were included in the study. The prevalence of depression was significantly higher in PWE (24.6 %) compared to controls (11.8 %) (OR: 2.0, 95 %CI: 1.433–2.905, p < 0.001). Anxiety disorders was significantly higher in PWE (OR: 1.6, 95 %CI: 1.101–2.397, p = 0.014). Factors independently associated to depression were female sex (OR: 2.7, 95 %CI: 1.115–6.343, p = 0.027), suicidal ideation (OR: 5.8, 95 %CI: 2.083–16.174, p = 0.001), and anxiety disorders (OR: 10.2, 95 %CI: 4.023–25.748, p < 0.001).
Conclusion
the prevalence of depression is high in PWE compared to controls in Douala. A systematic screening should be included in the follow-up of PWE.
{"title":"Prevalence of depression in people with epilepsy: A hospital-based study in Cameroon","authors":"Daniel Gams Massi , Richy Feudjio , Christian Eyoum , Lionel Paternoster , Annick Mélanie Magnerou , Nadine Tavares Ferreira , Jose-Antonio Elosegi , Callixte Kuate Tegueu , Njankouo Yacouba Mapoure","doi":"10.1016/j.yebeh.2025.110326","DOIUrl":"10.1016/j.yebeh.2025.110326","url":null,"abstract":"<div><h3>Introduction</h3><div>depression is a psychiatric disorder present in many chronic diseases with varying prevalences. In people with epilepsy (PWE), it represents the most frequent psychiatric comorbidity associated with impaired quality of life, and increased risk of suicide. The aim of this research was to determine the prevalence and factors associated with depression in PWE.</div></div><div><h3>Methods</h3><div>this was a cross-sectional study with an age- and sex- matched control group, conducted between February 12 and May 15, 2024, in two referral hospital of Douala. It included individuals (PWE and controls) aged 18 years and older who agreed to participate in the study. Individuals (PWE and controls) with a serious general health problem that could have a significant impact on mental status (hypertension, HIV, diabetes, renal failure, heart failure, dementia, bipolar disorder) or an inability to communicate were excluded. Recruitment was done through an online and in-person survey using a form. We collected sociodemographic data, and data on epilepsy in PWE. Depression was evaluated using the PHQ-9 scale. We used the Generalized Anxiety Disorder Questionnaire (GAD-7) to assess anxiety disorders. Univariate and multivariate analysis (binary logistic regression) were used to identify the factors significantly associated with depression in PWE. The significance threshold was considered for a value of p < 0.05.</div></div><div><h3>Results</h3><div>a total of 633 individuals, including 211 PWE, were included in the study. The prevalence of depression was significantly higher in PWE (24.6 %) compared to controls (11.8 %) (OR: 2.0, 95 %CI: 1.433–2.905, p < 0.001). Anxiety disorders was significantly higher in PWE (OR: 1.6, 95 %CI: 1.101–2.397, p = 0.014). Factors independently associated to depression were female sex (OR: 2.7, 95 %CI: 1.115–6.343, p = 0.027), suicidal ideation (OR: 5.8, 95 %CI: 2.083–16.174, p = 0.001), and anxiety disorders (OR: 10.2, 95 %CI: 4.023–25.748, p < 0.001).</div></div><div><h3>Conclusion</h3><div>the prevalence of depression is high in PWE compared to controls in Douala. A systematic screening should be included in the follow-up of PWE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110326"},"PeriodicalIF":2.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.yebeh.2025.110310
Kaiji Li , Haonan Li , Jinchao Wang , Xin Chen , Lei Li , Cong Wang , Shu Zhang , Jianning Zhang
Background
Observational studies have identified a strong correlation between epilepsy and sleep traits, highlighting their interactive relationship. However, no studies have specifically examined the associations between sleep traits and epilepsy. In this context, we conducted a Mendelian Randomization (MR) investigation to explore the causal nature of these associations.
Methods
We performed a two-sample Mendelian Randomization (MR) analysis model to genetically predict the causal effects of morning chronotype on epilepsy. Five MR analysis methods were conducted to analyze the final results. The inverse-variance weighted (IVW) method was used as the primary outcome. The other MR analysis methods (MR‐Egger; Weighted Mode; and Weighted median (WM)) were conducted as the complement to IVW. In addition, the robustness of the MR analysis results was assessed by leave-one-out analysis.
Results
In forward MR, epilepsy showed causal relationships with sleep duration (IVW beta = 0.008, P = 0.015). Specifically, doubling the odds of inheriting epilepsy may be associated with a 0.0075 standard deviation (SD) (95 % CI: 1.001 to 1.014) increase in sleep duration. In reverse MR, we found statistically significant associations between chronotype (evening preference) (OR = 1.397, p = 0.007) and insomnia (OR = 2.280, p = 0.025) and the risk of epilepsy.
Conclusion
Our two-sample Mendelian randomization analyses indicate that individuals with epilepsy frequently experience extended sleep duration. Additionally, we identified insomnia and chronotype (evening preference) as significant risk factors that increase the likelihood of developing epilepsy.
{"title":"Causal relationship between sleep traits and risk of Epilepsy: A Mendelian randomization study","authors":"Kaiji Li , Haonan Li , Jinchao Wang , Xin Chen , Lei Li , Cong Wang , Shu Zhang , Jianning Zhang","doi":"10.1016/j.yebeh.2025.110310","DOIUrl":"10.1016/j.yebeh.2025.110310","url":null,"abstract":"<div><h3>Background</h3><div>Observational studies have identified a strong correlation between epilepsy and sleep traits, highlighting their interactive relationship. However, no studies have specifically examined the associations between sleep traits and epilepsy. In this context, we conducted a Mendelian Randomization (MR) investigation to explore the causal nature of these associations.</div></div><div><h3>Methods</h3><div>We performed a two-sample Mendelian Randomization (MR) analysis model to genetically predict the causal effects of morning chronotype on epilepsy. Five MR analysis methods were conducted to analyze the final results. The inverse-variance weighted (IVW) method was used as the primary outcome. The other MR analysis methods (MR‐Egger; Weighted Mode; and Weighted median (WM)) were conducted as the complement to IVW. In addition, the robustness of the MR analysis results was assessed by leave-one-out analysis.</div></div><div><h3>Results</h3><div>In forward MR, epilepsy showed causal relationships with sleep duration (IVW beta = 0.008, P = 0.015). Specifically, doubling the odds of inheriting epilepsy may be associated with a 0.0075 standard deviation (SD) (95 % CI: 1.001 to 1.014) increase in sleep duration. In reverse MR, we found statistically significant associations between chronotype (evening preference) (OR = 1.397, p = 0.007) and insomnia (OR = 2.280, p = 0.025) and the risk of epilepsy.</div></div><div><h3>Conclusion</h3><div>Our two-sample Mendelian randomization analyses indicate that individuals with epilepsy frequently experience extended sleep duration. Additionally, we identified insomnia and chronotype (evening preference) as significant risk factors that increase the likelihood of developing epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110310"},"PeriodicalIF":2.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.yebeh.2025.110334
Francesca Chiesi , Carlotta Tagliaferro , Pietro Cappelletto , Carmen Barba
This scoping review aimed to evaluate specific measures of health-related quality of life (HRQoL) in children with epilepsy including patient- and proxy-reports, to determine their suitability for use in the clinical setting. We searched PubMed, Web of Science, PsycINFO Scopus for studies on the childhood epilepsy questionnaires identified as having better measurement properties and/or including proxy and parent reports. Then, we selected the studies that analyzed the agreement between child and caregiver ratings. We identified five scales i.e., the QoLPES, the HARCES, the PedsQL-Epilepsy Module, and the CHEQoL-25 and observed a moderate to high agreement between the proxy-reports and child self-reports. The CHEQoL-25 appears to be preferable due to its well-documented psychometric properties, high usability, and adequate agreement between proxy and child versions. This scoping review highlights the need to use PROMs that allow to gather information from both the caregiver and child, with the CHEQoL-25 being the best candidate for assessing HRQol in children with epilepsy.
{"title":"Reappraising self-report and proxy-report measures for assessing health-related quality of life in pediatric epilepsy: A scoping review","authors":"Francesca Chiesi , Carlotta Tagliaferro , Pietro Cappelletto , Carmen Barba","doi":"10.1016/j.yebeh.2025.110334","DOIUrl":"10.1016/j.yebeh.2025.110334","url":null,"abstract":"<div><div>This scoping review aimed to evaluate specific measures of health-related quality of life (HRQoL) in children with epilepsy including patient- and proxy-reports, to determine their suitability for use in the clinical setting. We searched PubMed, Web of Science, PsycINFO Scopus for studies on the childhood epilepsy questionnaires identified as having better measurement properties and/or including proxy and parent reports. Then, we selected the studies that analyzed the agreement between child and caregiver ratings. We identified five scales i.e., the QoLPES, the HARCES, the PedsQL-Epilepsy Module, and the CHEQoL-25 and observed a moderate to high agreement between the proxy-reports and child self-reports. The CHEQoL-25 appears to be preferable due to its well-documented psychometric properties, high usability, and adequate agreement between proxy and child versions. This scoping review highlights the need to use PROMs that allow to gather information from both the caregiver and child, with the CHEQoL-25 being the best candidate for assessing HRQol in children with epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110334"},"PeriodicalIF":2.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-24DOI: 10.1016/j.yebeh.2025.110330
Emma Colucci , Marie-Ève Landreville , Amélie Landry , Dang Khoa Nguyen , Arnaud Saj , Olivier Boucher
The nature of memory deficits in mesial temporal lobe epilepsy (mTLE) can depend on the side of the epileptogenic zone (EZ). Although left mTLE has been consistently associated with impairments in verbal memory, the association between right mTLE and non-verbal memory is less clear, which may be attributable to methodological limitations of existing visuospatial memory tests (e.g., possible use of verbalization strategies, involvement of psychomotor or visuospatial skills, task structure which differs between verbal and non-verbal memory tests). The Brown Location Test (BLT) was developed to evaluate visuospatial memory by addressing such limitations, and displays a good potential value for lateralizing the EZ. To our knowledge, no independent study has been conducted to assess the contribution of the BLT in lateralizing and localizing the EZ among patients undergoing pre-surgical assessment for drug-resistant focal epilepsy. This study aims to do so by comparing visuospatial and verbal memory performance of patients according to EZ lateralization (left vs. right) and localization (mesiotemporal vs. non-mesiotemporal). Eighty-nine adult patients with TLE were divided into four groups based on EZ (left mTLE, right mTLE, left non-mTLE, right non-mTLE) and were administered the BLT and the Rey Auditory Verbal Learning Test (RAVLT) pre-operatively. Memory performance was associated with sex, education and number of antiseizure medications. Only delayed recognition hits on the RAVLT showed the expected material-specific impairment associated with left mTLE, whereas BLT performance did not differ between groups. Therefore, caution is required when interpreting material-specific memory performances to localize and lateralize the EZ among patients undergoing pre-surgical assessment for drug-resistant epilepsy.
{"title":"Contribution of the Brown Location Test to the pre-surgical neuropsychological assessment of temporal lobe epilepsy","authors":"Emma Colucci , Marie-Ève Landreville , Amélie Landry , Dang Khoa Nguyen , Arnaud Saj , Olivier Boucher","doi":"10.1016/j.yebeh.2025.110330","DOIUrl":"10.1016/j.yebeh.2025.110330","url":null,"abstract":"<div><div>The nature of memory deficits in mesial temporal lobe epilepsy (mTLE) can depend on the side of the epileptogenic zone (EZ). Although left mTLE has been consistently associated with impairments in verbal memory, the association between right mTLE and non-verbal memory is less clear, which may be attributable to methodological limitations of existing visuospatial memory tests (e.g., possible use of verbalization strategies, involvement of psychomotor or visuospatial skills, task structure which differs between verbal and non-verbal memory tests). The Brown Location Test (BLT) was developed to evaluate visuospatial memory by addressing such limitations, and displays a good potential value for lateralizing the EZ. To our knowledge, no independent study has been conducted to assess the contribution of the BLT in lateralizing and localizing the EZ among patients undergoing pre-surgical assessment for drug-resistant focal epilepsy. This study aims to do so by comparing visuospatial and verbal memory performance of patients according to EZ lateralization (left vs. right) and localization (mesiotemporal vs. non-mesiotemporal). Eighty-nine adult patients with TLE were divided into four groups based on EZ (left mTLE, right mTLE, left non-mTLE, right non-mTLE) and were administered the BLT and the Rey Auditory Verbal Learning Test (RAVLT) pre-operatively. Memory performance was associated with sex, education and number of antiseizure medications. Only delayed recognition hits on the RAVLT showed the expected material-specific impairment associated with left mTLE, whereas BLT performance did not differ between groups. Therefore, caution is required when interpreting material-specific memory performances to localize and lateralize the EZ among patients undergoing pre-surgical assessment for drug-resistant epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110330"},"PeriodicalIF":2.3,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-21DOI: 10.1016/j.yebeh.2025.110297
Sarah Brown , Honor Coleman , Tammy Shella , Sarah J Wilson
Within the clinical and research spheres, there is increasing recognition of the importance of understanding the lived experience of ongoing illness and incorporating this voice into research and clinical practice. The current paper provides insights into the lived experience of undergoing epilepsy surgery, explored through the lens of art therapy. Six pieces of self-portraiture are presented that highlight key features of the burden of normality as experienced by joint first author Sarah Brown (SB) after her epilepsy surgery. Self-reflections from SB about her artwork are integrated with findings from the empirical literature that detail experiences of post-operative adjustment, providing novel insights into the post-operative adjustment process from the lived experience perspective. This approach highlights ways in which key findings from the research literature, which summates experiences at the group level, can be applied to the individual situation. The study also underscores the potential value of art therapy as a complementary therapy for holistic post-operative rehabilitation practices.
{"title":"The lived experience of the burden of normality: Explored through the lens of art therapy","authors":"Sarah Brown , Honor Coleman , Tammy Shella , Sarah J Wilson","doi":"10.1016/j.yebeh.2025.110297","DOIUrl":"10.1016/j.yebeh.2025.110297","url":null,"abstract":"<div><div>Within the clinical and research spheres, there is increasing recognition of the importance of understanding the lived experience of ongoing illness and incorporating this voice into research and clinical practice. The current paper provides insights into the lived experience of undergoing epilepsy surgery, explored through the lens of art therapy. Six pieces of self-portraiture are presented that highlight key features of the burden of normality as experienced by joint first author Sarah Brown (SB) after her epilepsy surgery. Self-reflections from SB about her artwork are integrated with findings from the empirical literature that detail experiences of post-operative adjustment, providing novel insights into the post-operative adjustment process from the lived experience perspective. This approach highlights ways in which key findings from the research literature, which summates experiences at the group level, can be applied to the individual situation. The study also underscores the potential value of art therapy as a complementary therapy for holistic post-operative rehabilitation practices.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110297"},"PeriodicalIF":2.3,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143465298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/j.yebeh.2025.110321
Annemarie Thaele , Lorenzo Barba , Samir Abu-Rumeileh , Matteo Foschi , Markus Otto
Epileptology − with epilepsy as one of the most common neurological diseases − has an urgent need for easily accessible biomarkers to improve diagnosis, prognosis and therapeutic monitoring. Neurofilament light chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) have emerged as promising fluid biomarkers in various neurological disorders. Their potential role in epileptic seizures and epilepsy remains largely unexplored. To assess the current state of research on this topic we comprehensively searched the published literature for studies on GFAP and/or NfL in cerebrospinal fluid and/or blood in adult humans with epileptic seizures, status epilepticus or epilepsy (last data base search on 10th of May 2024). We identified a total of 2285 publications of which 19 fulfilled our search criteria. The studies targeted various outcomes such as prognosis in status epilepticus, differentiation of seizure semiology and etiology, differentiation of epileptic seizures from non-epileptic conditions, prediction of epilepsy in autoimmune epilepsy, after a stroke or after a first unprovoked seizure, the role of the time interval from seizure to sampling, the association with disease duration as well as seizure frequency and the influence of seizure suppressing medication. The results are heterogeneous but indicate promising applications for both NfL and GFAP in diagnosis and prognostication of patients with epileptic seizures and epilepsy.
In the present review we summarize the current evidence, future perspectives, but also limitations, of NfL and GFAP as fluid biomarkers in epilepsy and epileptic seizures.
{"title":"Neurofilament light chain and glial fibrillary acidic protein as diagnostic and prognostic biomarkers in epileptic seizures and epilepsy: A systematic review","authors":"Annemarie Thaele , Lorenzo Barba , Samir Abu-Rumeileh , Matteo Foschi , Markus Otto","doi":"10.1016/j.yebeh.2025.110321","DOIUrl":"10.1016/j.yebeh.2025.110321","url":null,"abstract":"<div><div>Epileptology − with epilepsy as one of the most common neurological diseases − has an urgent need for easily accessible biomarkers to improve diagnosis, prognosis and therapeutic monitoring. Neurofilament light chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) have emerged as promising fluid biomarkers in various neurological disorders. Their potential role in epileptic seizures and epilepsy remains largely unexplored. To assess the current state of research on this topic we comprehensively searched the published literature for studies on GFAP and/or NfL in cerebrospinal fluid and/or blood in adult humans with epileptic seizures, status epilepticus or epilepsy (last data base search on 10th of May 2024). We identified a total of 2285 publications of which 19 fulfilled our search criteria. The studies targeted various outcomes such as prognosis in status epilepticus, differentiation of seizure semiology and etiology, differentiation of epileptic seizures from non-epileptic conditions, prediction of epilepsy in autoimmune epilepsy, after a stroke or after a first unprovoked seizure, the role of the time interval from seizure to sampling, the association with disease duration as well as seizure frequency and the influence of seizure suppressing medication. The results are heterogeneous but indicate promising applications for both NfL and GFAP in diagnosis and prognostication of patients with epileptic seizures and epilepsy.</div><div>In the present review we summarize the current evidence, future perspectives, but also limitations, of NfL and GFAP as fluid biomarkers in epilepsy and epileptic seizures.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110321"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/j.yebeh.2025.110291
Clemens Lang , Ekaterina Pataraia , Edda Haberlandt , Michael Feichtinger , Silvia Bonelli , Gudrun Gröppel , Moritz Feigl , Eugen Trinka , Christoph Baumgartner
We aimed to assess attitudes towards epilepsy and people with epilepsy (PWE) in Austria using a web-based survey including demographics, the Caveness questionnaire (CQ) and Scales of Attitudes toward People with Epilepsy questionnaire (SAPE). Furthermore, we compared our results with a previous Austrian study and investigated predictors for negative attitudes towards epilepsy and PWE.
Results from 1017 adult respondents familiar with epilepsy revealed that 66.8% had had personal contact with PWE and 51.1% had experienced an epileptic seizure firsthand. However, only 28.3% of respondents were able to identify half of the correct answers regarding epilepsy as a disease and treatment options. This is highly important, as these were the strongest predictors for more positive attitudes towards PWE. In SAPE, another strong predictor for more favorable attitudes was prior personal contact with PWE. Compared to 2005, familiarity with epilepsy, personal contact with PWE as well as firsthand experience of seizures, and support for employing PWE like others increased significantly. While we report a favorable slight decrease of respondents who consider epilepsy a form of insanity, there was no significant difference in objection of their children having contact with children with epilepsy and marriage of their children with PWE.
Thus, we demonstrate that even though familiarity with epilepsy and personal contact with PWE increased in Austria, there are still negative attitudes towards epilepsy and PWE present. Further education campaigns should focus especially on the areas of epilepsy knowledge, epilepsy treatment and what to do when someone has an epileptic seizure.
{"title":"Attitudes towards epilepsy in the Austrian general population: Predictors and national trends","authors":"Clemens Lang , Ekaterina Pataraia , Edda Haberlandt , Michael Feichtinger , Silvia Bonelli , Gudrun Gröppel , Moritz Feigl , Eugen Trinka , Christoph Baumgartner","doi":"10.1016/j.yebeh.2025.110291","DOIUrl":"10.1016/j.yebeh.2025.110291","url":null,"abstract":"<div><div>We aimed to assess attitudes towards epilepsy and people with epilepsy (PWE) in Austria using a web-based survey including demographics, the Caveness questionnaire (CQ) and Scales of Attitudes toward People with Epilepsy questionnaire (SAPE). Furthermore, we compared our results with a previous Austrian study and investigated predictors for negative attitudes towards epilepsy and PWE.</div><div>Results from 1017 adult respondents familiar with epilepsy revealed that 66.8% had had personal contact with PWE and 51.1% had experienced an epileptic seizure firsthand. However, only 28.3% of respondents were able to identify half of the correct answers regarding epilepsy as a disease and treatment options. This is highly important, as these were the strongest predictors for more positive attitudes towards PWE. In SAPE, another strong predictor for more favorable attitudes was prior personal contact with PWE. Compared to 2005, familiarity with epilepsy, personal contact with PWE as well as firsthand experience of seizures, and support for employing PWE like others increased significantly. While we report a favorable slight decrease of respondents who consider epilepsy a form of insanity, there was no significant difference in objection of their children having contact with children with epilepsy and marriage of their children with PWE.</div><div>Thus, we demonstrate that even though familiarity with epilepsy and personal contact with PWE increased in Austria, there are still negative attitudes towards epilepsy and PWE present. Further education campaigns should focus especially on the areas of epilepsy knowledge, epilepsy treatment and what to do when someone has an epileptic seizure.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110291"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-02-20DOI: 10.1016/j.yebeh.2025.110269
M.Scott Perry , Dax Bourcier , Paula Brna
The goal of epilepsy treatment is to achieve the most significant seizure reduction, aiming for seizure freedom, in the absence of consequential adverse effects. For children with drug resistant epilepsy (DRE), surgical therapy may offer the best chance of seizure freedom, but is vastly underutilized. In cases where seizure freedom is not possible, surgery may still provide meaningful seizure reduction over that expected from continued medical management. In addition, seizure freedom and reduction can have meaningful impact on non-seizure outcomes including mortality, cognition, behavior, and cost of care. It is essential to compare the relative risks and benefits of continued medical therapy versus surgical therapy in order to best inform choice of treatment in pediatric DRE and avoid unnecessary delays. In this review, we explore the seizure and non-seizure benefits of epilepsy surgery, including curative procedures and those expected to result in meaningful seizure reduction, compared to continued medical management in children.
{"title":"Surgical versus medical treatment of drug resistant epilepsy in children: Seizure and non-seizure outcomes","authors":"M.Scott Perry , Dax Bourcier , Paula Brna","doi":"10.1016/j.yebeh.2025.110269","DOIUrl":"10.1016/j.yebeh.2025.110269","url":null,"abstract":"<div><div>The goal of epilepsy treatment is to achieve the most significant seizure reduction, aiming for seizure freedom, in the absence of consequential adverse effects. For children with drug resistant epilepsy (DRE), surgical therapy may offer the best chance of seizure freedom, but is vastly underutilized. In cases where seizure freedom is not possible, surgery may still provide meaningful seizure reduction over that expected from continued medical management. In addition, seizure freedom and reduction can have meaningful impact on non-seizure outcomes including mortality, cognition, behavior, and cost of care. It is essential to compare the relative risks and benefits of continued medical therapy versus surgical therapy in order to best inform choice of treatment in pediatric DRE and avoid unnecessary delays. In this review, we explore the seizure and non-seizure benefits of epilepsy surgery, including curative procedures and those expected to result in meaningful seizure reduction, compared to continued medical management in children.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"165 ","pages":"Article 110269"},"PeriodicalIF":2.3,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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