Epilepsy & Behavior最新文献

{"title":"Numinous-like symptoms in epilepsy and/or insular tumors: A hospital cohort study","authors":"Fredrik K Andersson ,&nbsp;Bisrat Ezra ,&nbsp;Kenney Roy Roodakker ,&nbsp;Shala Berntsson ,&nbsp;Maria Zetterling ,&nbsp;Helena Gauffin ,&nbsp;A-M Landtblom","doi":"10.1016/j.yebeh.2026.110901","DOIUrl":"10.1016/j.yebeh.2026.110901","url":null,"abstract":"<div><h3>Objective</h3><div>Ecstatic seizures (EcS) have captured scientific interest due to their potential origin in anterior insular networks, emphasizing the insula’s role in self-processing. Their frequency in epilepsy or insular pathology has not been systematically studied. Present study aimed to examine the frequency and clinical characteristics of EcS in epilepsy patients, and the potential occurrence of ecstatic symptoms in insula tumor patients.</div></div><div><h3>Method</h3><div>Preformatted questionnaires on symptom reporting were sent to 200 epilepsy patients and 40 with resected insular tumors. Patients reporting EcS-related symptoms underwent in-person interviews. Hospital records, including EEG and imaging, were analyzed.</div><div>Seizure-related experiences with supernatural, religious, spiritual, mystical, or ecstatic features were referred to as “numinous-like symptoms” throughout the article.</div></div><div><h3>Results</h3><div>Interestingly, a variety of rare, numinous-like ictal experiences were found, all of which are discussed in this study. In the epilepsy cohort, 83 patients responded, five (6.0 %) reported symptoms that qualified them for interview and final analysis. In the tumor cohort, 23 patients responded, two (8.7 %) reported relevant symptoms, both with pre-existing epilepsy. During the interviews, we identified EcS (n = 1), ictal out-of-body experiences (OBE) (n = 2), and ictal sensed presence (SenP) (n = 5); one patient experienced both SenP and OBE. Three SenP patients had seizure origin in the right hemisphere: two had resected tumors in the temporo-insular region and one had mesial temporal sclerosis. The EcS patient had aphasia as an early seizure symptom and left-sided temporal interictal epileptiform activity. The remaining patients had less distinct investigational results.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that seizure-related numinous-like experiences are not uncommon and should be actively assessed, given the difficulty and reluctance of patients to speak about them, and their relevance for evaluating seizure freedom and differential diagnoses. Neuroscientifically, these phenomena offer insight into consciousness: EcS and OBE occupy distinct nodes in self-processing networks, whereas SenP requires further cognitive, psychological, and phenomenological analysis to guide future neurobiological research.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110901"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and tolerability of blue-tinted contact lenses in the treatment of Sunflower syndrome: A questionnaire-based study","authors":"Kennedy R. Geenen ,&nbsp;Samantha V. Yap ,&nbsp;Lydia Tsega ,&nbsp;Steven Cantrell ,&nbsp;Patricia L. Bruno ,&nbsp;Elizabeth A. Thiele","doi":"10.1016/j.yebeh.2026.110921","DOIUrl":"10.1016/j.yebeh.2026.110921","url":null,"abstract":"<div><h3>Aim</h3><div>The goal of this study was to assess the efficacy and tolerability of the Cantrell Notch Filtering soft contact lens as a treatment for patients with Sunflower syndrome.</div></div><div><h3>Methods</h3><div>A questionnaire was distributed to patients with Sunflower syndrome that were being treated with the Cantrell Notch Filtering contact lenses. The survey was hosted on REDCap, and covered topics pertaining to the respondent’s history of Sunflower syndrome, including frequency of seizures, tolerability of the lenses, and the perceived benefit of the lenses with regard to reduction of handwaving episodes.</div></div><div><h3>Results</h3><div>Nineteen people participated in this study. Sixteen of the 19 respondents provided numerical data regarding the frequency of handwaving episodes with and without contact lenses. At the time of survey completion, the average length of time that patients reported wearing the contact lenses was 11.5 months (range: 1 week-2 years 6 months). There was an average 72.9% reduction in handwaving episodes with the use of the contact lenses. Many respondents were able to reduce the use of other non-pharmacological interventions, such as hats and sunglasses, while wearing the contact lenses. However, 10 respondents (52.6%) reported difficulty with tolerability of the contact lenses, including stinging, burning, and color distortion. Of note, these contact lenses filter light between 250 and 650 nm, compared to a Zeiss Z1 lens which filters light between 550 and 700 nm.</div></div><div><h3>Conclusion</h3><div>The Cantrell Notch Filtering contact lens for Sunflower syndrome may be a beneficial non-pharmacological treatment option for some patients with Sunflower syndrome, although many patients have difficulty with tolerability.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110921"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146074088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and neuroimaging features of PRRT2-related epilepsy in adult patients","authors":"Yi Yan ,&nbsp;Yuling Yang ,&nbsp;Yang Cai ,&nbsp;Shaoping Zhong ,&nbsp;Kaiyuan Shen ,&nbsp;Xin Wang ,&nbsp;Jing Ding","doi":"10.1016/j.yebeh.2025.110868","DOIUrl":"10.1016/j.yebeh.2025.110868","url":null,"abstract":"<div><h3>Objective</h3><div>While proline-rich transmembrane protein 2 (<em>PRRT2</em>) variants have been reported in association with self-limited infantile epilepsy (SeLIE), their relevance to adult epilepsy remains largely uncharacterized. Therefore, we investigated the prevalence of <em>PRRT2</em> variants in an adult epilepsy cohort to broaden their phenotypic spectrum.</div></div><div><h3>Methods</h3><div>In a cohort of adult patients with epilepsy who underwent whole-exome sequencing (WES), individuals harboring <em>PRRT2</em> variants were identified and selected for further analysis. Amino acid conservation among species, combined with functional verification of mutant proteins, was performed to assess the pathogenicity of novel <em>PRRT2</em> variants. Furthermore, electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) were conducted in patients carrying <em>PRRT2</em> variants.</div></div><div><h3>Results</h3><div>Two novel missense variants (c.643C &gt; A/ p.P215T and c.932G &gt; A/ p.R311Q) were demonstrated to impair protein expression, indicating a likely haploinsufficiency mechanism. Nine cases were identified carrying <em>PRRT2</em> variants, including the c.649dupC hotspot variant and two missense variants. The age of seizure onset was predominantly during infancy or adolescence, with epilepsy persisting or relapsing into adulthood. Drug-resistant epilepsy was observed in two cases, whereas others were primarily controlled through sodium channel blockers. Unlike previously reported normal interictal EEG findings in <em>PRRT2</em>-related disorders, epileptiform discharges were recorded in the majority of patients. fMRI revealed reduced thalamocortical connectivity, indicating disrupted brain network integration.</div></div><div><h3>Conclusions</h3><div>This study expands the genotypic and phenotypic spectrum of <em>PRRT2</em>-related disorders, links its variants to epileptiform discharges, and reveals impaired network integration in <em>PRRT2</em>-associated epilepsy.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110868"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146003392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective connectivity of face and fear processing in juvenile myoclonic epilepsy","authors":"Christina Münchberger ,&nbsp;Kristina Krause ,&nbsp;Louise Linka ,&nbsp;Sascha Strehlau ,&nbsp;Anna Sophia Huber ,&nbsp;Julia Freigang ,&nbsp;Andreas Jansen ,&nbsp;Katja Menzler ,&nbsp;Susanne Knake ,&nbsp;Kristin M. Rusch","doi":"10.1016/j.yebeh.2025.110863","DOIUrl":"10.1016/j.yebeh.2025.110863","url":null,"abstract":"<div><h3>Objective</h3><div>Individuals with Juvenile Myoclonic Epilepsy (JME) exhibit impaired facial emotion perception, especially regarding fear. However, the underlying neural mechanisms remain to be fully understood. Particularly, the connectivity between emotion-related regions, such as the amygdala, and visual face-processing areas, specifically the Fusiform Face Area (FFA), appears to be relevant for typical facial fear processing. We therefore explored the effective connectivity within the FFA-amygdala network in JME.</div></div><div><h3>Methods</h3><div>Fourteen individuals diagnosed with JME and 14 healthy controls matched for age, sex, and alexithymia (i.e., emotional awareness) participated in an fMRI face-viewing experiment. Participants were presented with images of neutral and fearful faces, as well as houses. Using Dynamic Causal Modelling, we examined endogenous connectivity, modulation by task conditions, and the influence of experimental inputs within the bilateral FFA-amygdala network (n = 24), incorporating both intra- and interhemispheric connections.</div></div><div><h3>Results</h3><div>Compared to healthy controls, we found alterations mainly in the task-independent endogenous structure of the FFA-amygdala network in JME. The self-connection of the right amygdala was particularly enhanced, with the same tendency observed for the left amygdala and the right FFA. Furthermore, aberrations were indicated in the interhemispheric transfer between the amygdalae under the modulation of fear. Exploratory analyses revealed correlations of neural activity, and neural network parameters with both the onset and duration of epilepsy.</div></div><div><h3>Conclusion</h3><div>Overall, we found initial evidence of alterations in the FFA-amygdala network in JME. Particularly, the right amygdala showed a greater inhibitory self-connection, which suggests a generally reduced sensitivity to external input and might affect social and emotional processing. This emphasizes further exploring the network structure, its behavioural implications, and connectivity with other regions in larger samples.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110863"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145898142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The social and occupational functioning Scale for epilepsy (SOFSE): Russian adaptation and psychometric performance in adults with epilepsy","authors":"Anna Gersamija ,&nbsp;Georgii Kustov ,&nbsp;Ilya Mishin ,&nbsp;Mikhail Zinchuk ,&nbsp;Flora Rider ,&nbsp;Alla Guekht","doi":"10.1016/j.yebeh.2026.110911","DOIUrl":"10.1016/j.yebeh.2026.110911","url":null,"abstract":"<div><h3>Objective</h3><div>To develop and validate a Russian version of the Social and Occupational Functioning Scale for Epilepsy (SOFSE), addressing the lack of a validated Russian-language instrument for assessing social functioning in people with epilepsy (PWE), despite the high prevalence of epilepsy and persistent stigma in the Russian Federation.</div></div><div><h3>Methods</h3><div>Following established cross-cultural adaptation guidelines, the Russian SOFSE was administered to 545 consecutively recruited adults with epilepsy (mean age 43.2 years; 53.9 % women) at a Level 2 Epilepsy Center, alongside the Hospital Anxiety and Depression Scale (HADS) and QOLIE-31. Factor structure (via confirmatory factor analysis), internal consistency (McDonald’s ω), and discriminant validity were assessed.</div></div><div><h3>Results</h3><div>Confirmatory factor analysis supported a unidimensional structure (RMSEA = 0.051; CFI = 0.955; TLI = 0.946). McDonald’s ω coefficients ranged from 0.51 (‘With a paying job’) to 0.80 (‘Instrumental Living Skills’), indicating adequate internal consistency overall, though somewhat lower for the employment-related subscale. Cluster analysis identified two groups with differential functional impairment (n = 352 vs. 193). Individuals in the impaired cluster demonstrated significantly poorer quality of life (QOLIE-31 total: 45.1 ± 29.5 vs. 61.9 ± 14.9; p &lt; 0.001) and higher levels of depressive (HADS-D: 8.4 ± 4.1 vs. 4.65 ± 3.3; p &lt; 0.001) and anxiety symptoms (HADS-A: 9.5 ± 4.4 vs. 6.4 ± 4.1; p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The Russian SOFSE shows overall adequate psychometric properties and is a clinically feasible instrument for assessing social functioning in PWE, although reliability was somewhat weaker for leisure and work-related items. Its strong association with depression and quality of life highlights the importance of routinely screening for psychiatric comorbidities – particularly depression – and integrating biopsychosocial interventions (e.g., psychological support, rehabilitation) to mitigate functional decline.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110911"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Orientation to daily Occupational Performance Approach using telerehabilitation with parents to improve performance issues in children/adolescents with Dravet Syndrome","authors":"Patrizia Gabriella Ianes ,&nbsp;Rose Martini ,&nbsp;Silvia Frazzetta ,&nbsp;Yann Bertholom ,&nbsp;Maria Giulia Montecchi ,&nbsp;Valentina De Luca ,&nbsp;Simone Di Lisa ,&nbsp;Costanza Cutrona ,&nbsp;Federica Moriconi ,&nbsp;Michela Quintiliani ,&nbsp;Simona Borroni ,&nbsp;Filomena Rita Rega ,&nbsp;Daniela Pia Rosaria Chieffo ,&nbsp;Domenica Immacolata Battaglia","doi":"10.1016/j.yebeh.2025.110803","DOIUrl":"10.1016/j.yebeh.2025.110803","url":null,"abstract":"<div><h3>Introduction</h3><div>The Cognitive Orientation to Occupational Performance (CO-OP) Approach, a problem-solving intervention process, has been shown to improve activity performance in children with Dravet Syndrome (DS). However, some individuals with DS have cognitive, language and/or behavioral deficits that preclude their ability to participate in the problem-solving process. To date, the CO-OP Approach has never been applied to parents with the goal of enhancing children/adolescent’s performance.</div></div><div><h3>Objective</h3><div>Explore the feasibility of a telerehabilitation-based CO-OP Approach with parents of individuals with DS to improve their child/adolescent’s performance in daily activities.</div></div><div><h3>Methods</h3><div>A quasi-experimental single group design with pretest-post-test and 1-month follow-up was used with 9 parents of children/adolescents with DS (aged 9–18 years), who received eight online CO-OP sessions. Five goals were chosen, three of which were treated. Parents rated performance and satisfaction on the Canadian Occupational Performance Measure (COPM). Activity performance was rated using the Performance Quality Rating Scale (PQRS). Wilcoxon signed-rank tests were conducted to assess intervention changes.</div></div><div><h3>Results</h3><div>COPM results, for trained and untrained goals, for both performance and satisfaction, improved significantly at post and follow-up. PQRS results for trained goals improved significantly at post and follow-up. Positive trends were also observed for untrained goals, but significance was achieved only at follow-up.</div></div><div><h3>Conclusion</h3><div>These findings provide preliminary evidence that the CO-OP Approach can be implemented with parents to improve their child/adolescent’s performance on both trained and untrained goals.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110803"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotion recognition deficits in temporal lobe epilepsy are non-lateralized and independent of surgery","authors":"Jana Amlerova ,&nbsp;Viktoria Pytelova ,&nbsp;Francesco Angelucci ,&nbsp;Ross Andel ,&nbsp;Jakub Hort ,&nbsp;Alena Javurkova ,&nbsp;Petr Marusic","doi":"10.1016/j.yebeh.2026.110906","DOIUrl":"10.1016/j.yebeh.2026.110906","url":null,"abstract":"<div><div>To examine whether patients with unilateral temporal lobe epilepsy (TLE) show deficits in recognizing emotions from facial expressions and vocal prosody, and whether these impairments differ by seizure focus or surgical status.</div></div><div><h3>Methods:</h3><div>Thirty-four patients with TLE were evaluated before or after temporal lobe resection for drug-resistant epilepsy. Thirty right-handed healthy controls without neurological or psychiatric history were included. Emotion recognition was assessed using the Emotion Recognition Test (ERT), consisting of a Facial ERT (adapted from Ekman and Friesen’s facial expression set) and a Prosody ERT developed in collaboration with professional actors using two neutral Czech sentences. Both subtests included five emotions: anger, disgust, fear, happiness, and sadness.</div></div><div><h3>Results:</h3><div>TLE patients showed a general impairment in emotion recognition across both modalities. Total prosody and facial emotion scores were significantly lower than in controls. Prosody deficits and facial emotion scores were independent of age, disease duration, and education. No significant differences were found between right and left TLE, or between pre- and postoperative groups.</div></div><div><h3>Significance:</h3><div>Deficits in emotion recognition from face and voice in patients with TLE were not lateralized and did not differ between pre- and postoperative TLE groups. This may indicate persistent socio-emotional processing abnormalities that may contribute to the social and behavioral difficulties observed in TLE people. Longitudinal studies are needed in this field.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110906"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illness Perception, Coping, and psychosocial outcomes in children with functional neurological disorders compared to children with epilepsy","authors":"Barbara Zuro Jakovac ,&nbsp;David Hevey ,&nbsp;Phillip Coey ,&nbsp;Clare Harris ,&nbsp;Gary Byrne","doi":"10.1016/j.yebeh.2026.110910","DOIUrl":"10.1016/j.yebeh.2026.110910","url":null,"abstract":"<div><div>This study explored differences in illness perceptions, coping, and psychosocial outcomes in children with functional neurological disorders (FND) and epilepsy. It also examined moderating and mediating role of coping between illness perceptions and psychosocial outcomes.</div><div>A cross-sectional design was used. Thirty-three children with FND and thirty-two with epilepsy completed measures of illness perceptions, coping, anxiety, depression, and health-related quality of life.</div><div>Children with FND reported more threatening illness perceptions, higher levels of anxiety and depression, and poorer quality of life. In both groups, threatening illness perceptions were positively correlated with anxiety, and negatively with quality of life. A positive correlation between illness perceptions and depression was found only among children with FND. Coping moderated these relationships differently across groups. In the FND group, it moderated the association between illness perceptions and quality of life, whereas in the epilepsy group, it moderated the association between illness perceptions and depression.</div><div>These findings highlight the importance of addressing illness perceptions and supporting children to use coping strategies they find helpful. Moreover, screening for illness perceptions and coping may help identify the most vulnerable children and inform treatment targets.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110910"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring health information and resource needs of women with epilepsy in Ireland from preconception to postpartum: A qualitative study","authors":"Jade Parnell ,&nbsp;Veronica Lambert ,&nbsp;Sinéad Murphy ,&nbsp;Fergal O’Shaughnessy ,&nbsp;Aisling Walsh","doi":"10.1016/j.yebeh.2025.110825","DOIUrl":"10.1016/j.yebeh.2025.110825","url":null,"abstract":"<div><div>Many women with epilepsy (WWE) navigate complex decisions regarding their reproductive health. In order to support these women throughout the stages of preconception to postpartum, it is important they are equipped with the relevant information and resources. The current study used an inductive qualitative method to understand the experiences and perspectives of WWE navigating health information across the stages of preconception to postpartum in Ireland. Thirty-two WWE aged 20–50 years, who have received healthcare in Ireland, participated in an online narrative interview. Responses were analysed using Reflexive Thematic Analysis. WWE reported several important factors related to their information needs. Three themes were developed: 1) what I need to know, to know what to expect (i.e., WWE’s need for information earlier to make informed decisions), 2) my information is impacted by access and support, and 3) my experiences impact whether I trust health information. Strategies to improve the timing and delivery of resources should be prioritised to increase the overall quality of communication of information for WWE to ensure their health needs are met.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110825"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146035127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of cognitive phenotypes in temporal lobe epilepsy and genetic generalized epilepsy using robotic assessment","authors":"Theodore S. Aliyianis ,&nbsp;Spencer Finn ,&nbsp;Karla Batista Garcia-Ramo ,&nbsp;Brooke C. Beattie ,&nbsp;Lysa Boissé Lomax ,&nbsp;Garima Shukla ,&nbsp;Stephen H. Scott ,&nbsp;Gavin P. Winston","doi":"10.1016/j.yebeh.2025.110875","DOIUrl":"10.1016/j.yebeh.2025.110875","url":null,"abstract":"<div><h3>Background</h3><div>Cognitive dysfunction is common in people with epilepsy (PWE). Although expectations exist for deficits based on diagnosis, phenotypic variation of cognitive deficits is observed within epilepsy subtypes. Classification by severity and type of cognitive deficits has been shown across multiple studies of people with temporal lobe epilepsy (TLE). In this study, we replicate these findings using robotic assessment in TLE and apply the same method in genetic generalized epilepsy (GGE) to uncover potential cognitive phenotypes.</div></div><div><h3>Method</h3><div>Participants with TLE and GGE were recruited to participate in robotic assessment battery of neurocognitive function. We used 7 task scores to form clusters that includes functions from various cognitive and motor domains. Calinski-Harabasz method seeded at zero was used to find the optimal value of c, and fuzzy C-means clustering was used to assess the cluster membership from the data in c-groups.</div></div><div><h3>Results</h3><div>We found 3 clusters among TLE (n = 33): minimal deficits (45 % of participants with TLE), partial deficits (27 %), and global deficits (27 %). Likewise, we found 3 clusters among GGE (n = 25): memory and executive deficits (40 % of participants with GGE), processing speed deficits (36 %), and complex motor deficits (24 %).</div></div><div><h3>Conclusions</h3><div>Robotic assessment can be used with clustering methods to classify cognitive dysfunction in epilepsy. These clusters show similar patterns to previous research, which suggests that robotic assessment can distinguish the cognitive phenotypes of PWE.</div></div>","PeriodicalId":11847,"journal":{"name":"Epilepsy & Behavior","volume":"176 ","pages":"Article 110875"},"PeriodicalIF":2.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}