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Uveal melanoma: ESMO–EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up† 葡萄膜黑色素瘤：ESMO-EURACAN临床实践指南：诊断、治疗和随访†
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 Epub Date: 2026-04-02 DOI: 10.1016/j.esmoop.2026.106888
S. Piperno-Neumann , M. Angi , P.A. Ascierto , J.F. Baurain , M.C. Burgmans , N. Cassoux , S.E. Coupland , R. Dendale , A. Fortuna , L. Gastaud , C. Gutierrez-Miguelez , S. Heegaard , M.J. Jager , E. Kapiteijn , U. Keilholz , E. Kilic , M. Marinkovic , A. Moulin , P. Nathan , S.P. Patel , O. Michielin
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引用次数: 0
LBA4 Sacituzumab tirumotecan (sac-TMT) in patients (pts) with previously treated advanced EGFR-mutated (EGFRm) non-small cell lung cancer (NSCLC): Final overall survival (OS) analysis from the randomized OptiTROP-Lung03 study 来自OptiTROP-Lung03随机研究的最终总生存期（OS）分析：先前治疗过的晚期egfr突变（EGFRm）非小细胞肺癌（NSCLC）患者（pts）的舒妥珠单抗替鲁替康（sac-TMT）
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 Epub Date: 2026-03-17 DOI: 10.1016/j.esmoop.2026.106960
W.F. Fang , X. Li , Q. Wang , X. Meng , W. Zheng , L. Sun , W. Yao , W. Zhuang , Y. Fan , M. Zhuo , Y. Luo , Z. Zhang , X. Song , R. Yang , J. Yang , Y. Diao , J. Ge , L. Zhang , Y. Yang
{"title":"LBA4 Sacituzumab tirumotecan (sac-TMT) in patients (pts) with previously treated advanced EGFR-mutated (EGFRm) non-small cell lung cancer (NSCLC): Final overall survival (OS) analysis from the randomized OptiTROP-Lung03 study","authors":"W.F. Fang , X. Li , Q. Wang , X. Meng , W. Zheng , L. Sun , W. Yao , W. Zhuang , Y. Fan , M. Zhuo , Y. Luo , Z. Zhang , X. Song , R. Yang , J. Yang , Y. Diao , J. Ge , L. Zhang , Y. Yang","doi":"10.1016/j.esmoop.2026.106960","DOIUrl":"10.1016/j.esmoop.2026.106960","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106960"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147748460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
56P LncRNAs FENDRR, LINC02560, and SOX21-AS1 regulate chemoresistance in advanced gastric cancer 56P LncRNAs FENDRR、LINC02560和SOX21-AS1调控晚期胃癌的化疗耐药
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106162
I. Riquelme , P. Pérez-Moreno , B. Mora , S. Rivas-Lara , C. Rojas-Fuentes , P.E. Yanez Weber , J.C. Roa , C. Ili , P. Brebi
{"title":"56P LncRNAs FENDRR, LINC02560, and SOX21-AS1 regulate chemoresistance in advanced gastric cancer","authors":"I. Riquelme , P. Pérez-Moreno , B. Mora , S. Rivas-Lara , C. Rojas-Fuentes , P.E. Yanez Weber , J.C. Roa , C. Ili , P. Brebi","doi":"10.1016/j.esmoop.2026.106162","DOIUrl":"10.1016/j.esmoop.2026.106162","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106162"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
51eP CTC-targeted allogeneic CAR-T cells as a novel approach to early recurrence in operative PDAC 51eP ctc靶向异体CAR-T细胞作为手术性PDAC早期复发的新途径
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106156
J. Wierciak , K. Bak , N. Wilczynska-Zawal , K. Rapacz , H. Plutecka , Z. Szwalec , J. Kijowski , M. Sierzega , M. Piejko
{"title":"51eP CTC-targeted allogeneic CAR-T cells as a novel approach to early recurrence in operative PDAC","authors":"J. Wierciak , K. Bak , N. Wilczynska-Zawal , K. Rapacz , H. Plutecka , Z. Szwalec , J. Kijowski , M. Sierzega , M. Piejko","doi":"10.1016/j.esmoop.2026.106156","DOIUrl":"10.1016/j.esmoop.2026.106156","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106156"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
53P Epigenetic modulation of TERRA by FTSJ3 supports telomerase-mediated oncogenesis FTSJ3对TERRA的53P表观遗传调控支持端粒酶介导的肿瘤发生
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106159
N. Jette , J. Price , O. Abuhussein , G. Groot , F. Vizeacoumar , A. Freywald , F. Vizeacoumar
{"title":"53P Epigenetic modulation of TERRA by FTSJ3 supports telomerase-mediated oncogenesis","authors":"N. Jette , J. Price , O. Abuhussein , G. Groot , F. Vizeacoumar , A. Freywald , F. Vizeacoumar","doi":"10.1016/j.esmoop.2026.106159","DOIUrl":"10.1016/j.esmoop.2026.106159","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106159"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
126eP Prognostic impact of concomitant genomic alterations in FGFR2-positive cholangiocarcinoma treated with pemigatinib: Molecular analysis of the Italian real-world study pemigatinib治疗fgfr2阳性胆管癌伴发基因组改变对预后的影响：意大利现实世界研究的分子分析
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106267
C. Liguori , R. Giampieri , A. Parisi , M. Niger , C. Sciortino , S.K. Garattini , A. Pastorino , A. Diana , A. Palloni , L. Foltran , S. Gobba , M. Mandalà , M. Bensi , M. Rimini , R. Balsano , D. Lavacchi , S. Marchetti , A. Alberti , C. Vivaldi , R. Berardi
{"title":"126eP Prognostic impact of concomitant genomic alterations in FGFR2-positive cholangiocarcinoma treated with pemigatinib: Molecular analysis of the Italian real-world study","authors":"C. Liguori , R. Giampieri , A. Parisi , M. Niger , C. Sciortino , S.K. Garattini , A. Pastorino , A. Diana , A. Palloni , L. Foltran , S. Gobba , M. Mandalà , M. Bensi , M. Rimini , R. Balsano , D. Lavacchi , S. Marchetti , A. Alberti , C. Vivaldi , R. Berardi","doi":"10.1016/j.esmoop.2026.106267","DOIUrl":"10.1016/j.esmoop.2026.106267","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106267"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3P Clinical significance of achieving no evidence of disease in HER2-positive metastatic breast cancer: A multicenter study by Turkish Oncology Group (TOG) her2阳性转移性乳腺癌无疾病证据的3P临床意义：土耳其肿瘤组（TOG）的一项多中心研究
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106106
B. Dursun , S. Yaslikaya , S. Sekmek , T. Önder , H.C. Yildirim , O. Acar , N. Sever , S. Gokcek , S. Ön , F. Aslan , G.S.Y. Keskin , Z. Sucuoglu Isleyen , G. Savas , M.E. Kalender , O. Bal , U.Y. Arslan , M. Sahbazlar , B. Cakar , H.M. Türk , H. Akbulut
{"title":"3P Clinical significance of achieving no evidence of disease in HER2-positive metastatic breast cancer: A multicenter study by Turkish Oncology Group (TOG)","authors":"B. Dursun , S. Yaslikaya , S. Sekmek , T. Önder , H.C. Yildirim , O. Acar , N. Sever , S. Gokcek , S. Ön , F. Aslan , G.S.Y. Keskin , Z. Sucuoglu Isleyen , G. Savas , M.E. Kalender , O. Bal , U.Y. Arslan , M. Sahbazlar , B. Cakar , H.M. Türk , H. Akbulut","doi":"10.1016/j.esmoop.2026.106106","DOIUrl":"10.1016/j.esmoop.2026.106106","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106106"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
18P Targeting MET-expressing NSCLC with a VNAR-based theranostic agent 18P靶向表达met的NSCLC与基于vnar的治疗剂
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106121
J. West , R. Minne , K. Nickel , G. Gunaratne , R. Hernandez , A. Baschnagel , R. Kimple , A. Lebeau
{"title":"18P Targeting MET-expressing NSCLC with a VNAR-based theranostic agent","authors":"J. West , R. Minne , K. Nickel , G. Gunaratne , R. Hernandez , A. Baschnagel , R. Kimple , A. Lebeau","doi":"10.1016/j.esmoop.2026.106121","DOIUrl":"10.1016/j.esmoop.2026.106121","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106121"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
36P Reclassification of 9,534 germline VUS in ATM and PALB2 via alphamissense and structural modeling: Unveiling predicted targets for precision oncology 通过字母错义和结构建模对9534个ATM和PALB2种系VUS进行重分类：揭示精准肿瘤学预测靶点
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106140
A. Kuskucu , O.A. Cavus
{"title":"36P Reclassification of 9,534 germline VUS in ATM and PALB2 via alphamissense and structural modeling: Unveiling predicted targets for precision oncology","authors":"A. Kuskucu , O.A. Cavus","doi":"10.1016/j.esmoop.2026.106140","DOIUrl":"10.1016/j.esmoop.2026.106140","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106140"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
94P Autophagy supports the drug-tolerant persister state during targeted therapy in colorectal cancer 94P自噬支持结直肠癌靶向治疗过程中的耐药持续状态
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106236
T. Li, M. Putz, A. Maghnouj, R. Hafez, S. Hahn
{"title":"94P Autophagy supports the drug-tolerant persister state during targeted therapy in colorectal cancer","authors":"T. Li, M. Putz, A. Maghnouj, R. Hafez, S. Hahn","doi":"10.1016/j.esmoop.2026.106236","DOIUrl":"10.1016/j.esmoop.2026.106236","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106236"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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