ESMO Open最新文献

{"title":"96P OC201 and OC202e synergistically suppress EMT and metastasis by dual inhibition of PKCε–NFκB signaling and autophagy in pancreatic cancer","authors":"D.S. Jung, Y. Kim, S. Kim, S.J. Sung, Y. Kim, K.S. Song, H. Won, Y.R. Kim, J. Kang","doi":"10.1016/j.esmoop.2026.106238","DOIUrl":"10.1016/j.esmoop.2026.106238","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106238"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"115P Liposomal irinotecan (HR070803) plus fluorouracil and bevacizumab as second-line treatment in patients with advanced colorectal cancer: Cohort A results from a phase II trial","authors":"H. Hu , H. Li , F. Xuefeng , S. Weng , K. Wang , Y. Yuan","doi":"10.1016/j.esmoop.2026.106256","DOIUrl":"10.1016/j.esmoop.2026.106256","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106256"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"122eP Preclinical investigation of the potential synergistic action of small molecule inhibitors in combination with chemotherapy in colon and liver cancer cells","authors":"C.M. Neophytou, E. Koulermou, M. Christou","doi":"10.1016/j.esmoop.2026.106263","DOIUrl":"10.1016/j.esmoop.2026.106263","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106263"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"124eP Clinical response of sorafenib in a patient with poorly differentiated thyroid carcinoma and respiratory failure, with c-Kit slightly positive and other markers negative","authors":"A. Xhuveli","doi":"10.1016/j.esmoop.2026.106265","DOIUrl":"10.1016/j.esmoop.2026.106265","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106265"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"76P Computational identification of shared neoantigens from TP53, KRAS, and BRAF hotspot mutations for pan-cancer therapeutic vaccine development","authors":"C.G. Ekmekci","doi":"10.1016/j.esmoop.2026.106217","DOIUrl":"10.1016/j.esmoop.2026.106217","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106217"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"91O Phase I results PI3Ka inhibitor TOS-358","authors":"V. Abramson , B. Doger de Spéville , T.C. Hernandez Guerrero , A. Giordano , J. Bartolomé Arcilla , A. Varkaris , G.M. Wulf , M.A. Salkeni , J.M. Lopez-Picazo Gonzalez , V. Boni , G. Alonso Casal , Z. Goldberg","doi":"10.1016/j.esmoop.2026.106233","DOIUrl":"10.1016/j.esmoop.2026.106233","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106233"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of comprehensive inflammatory-metabolic status and perioperative outcomes in gastric cancer: insights from four randomized controlled trials","authors":"L.-K. Zhang ,&nbsp;Z.-X. Shang-Guan ,&nbsp;H.-L. Zheng ,&nbsp;H.-H. Zheng ,&nbsp;C.-Y. Zheng ,&nbsp;W.-F. Chen ,&nbsp;J.-W. Xie","doi":"10.1016/j.esmoop.2026.106922","DOIUrl":"10.1016/j.esmoop.2026.106922","url":null,"abstract":"<div><h3>Background</h3><div>Inflammatory and metabolic status play a key role in the prognosis of gastric cancer (GC) patients. This study aimed to develop a novel comprehensive inflammatory-metabolic index (CIMI) to predict the risk of perioperative complications and prolonged hospital stay in GC patients.</div></div><div><h3>Patients and methods</h3><div>This study included 567 stage II-III GC patients from four randomized, controlled trials RCTs as the development cohort, and 107 patients from an external cohort as the validation set. Preoperative hematological and body composition parameters were used to evaluate inflammatory-metabolic status. The predictive performance of CIMI was evaluated using receiver operating characteristic (ROC), precision-recall (PR), decision curve analysis (DCA) curves, and model fit indices [deviance, Akaike information criterion (AIC), Bayesian information criterion (BIC)]. Subgroup and survival analyses were conducted to further explore the clinical utility of CIMI.</div></div><div><h3>Results</h3><div>CIMI was calculated using the formula: log[white blood cell count (10⁹/l) × serum globulin (g/l)] × visceral adiposity index (VAI). In the development cohort, the areas under the curve (AUC) for CIMI were 0.748 (post-operative complications) and 0.651 (length of stay &gt;11 days], outperforming existing inflammatory/metabolic indicators. Similar results were observed in the validation cohort, further confirming its robust predictive ability. Additionally, CIMI was significantly associated with intraoperative surgical time and post-operative recovery time. Subgroup analysis showed that, after adjusting for variables, the high-risk CIMI group had a significantly higher incidence of post-operative complications than the low-risk group (odds ratio = 7.77, 95% confidence interval 4.39-13.75, <em>P</em> &lt; 0.001). Survival analysis revealed that in the low-risk CIMI group, patients who initiated adjuvant chemotherapy within 6 weeks (time to chemotherapy &lt;6 weeks) had a significantly better 5-year overall survival rate than those with time to chemotherapy ≥6 weeks (56.0% versus 45.0%, <em>P</em> = 0.043). The online CIMI calculator provides clinicians with a convenient tool to support individualized treatment decision-making.</div></div><div><h3>Conclusions</h3><div>As a novel inflammatory-metabolic index, CIMI effectively predicts the risk of post-operative complications and prolonged hospital stay in GC patients, providing valuable insights for clinical decision-making and health care system strategies.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 4","pages":"Article 106922"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"57TiP PARPA-293-003: Phase Ia/Ib study of NMS-03305293 (Itareparib), a brain-penetrant, non-trapping PARP1-selective inhibitor, in combination with topotecan in recurrent HR proficient platinum-resistant/refractory ovarian cancer","authors":"D. Roberti ,&nbsp;A. Jazaeri ,&nbsp;P.H. Thaker ,&nbsp;L.P. Martin ,&nbsp;J.S. Russell ,&nbsp;S. Westin ,&nbsp;S. Maruzzelli ,&nbsp;B. Sherer ,&nbsp;L. Mahnke ,&nbsp;J. Merriman","doi":"10.1016/j.esmoop.2026.106163","DOIUrl":"10.1016/j.esmoop.2026.106163","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106163"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"42P Stage-specific long non-coding RNA signatures in human prostate tissue enhance diagnostic precision and predict aggressive and castration-resistant disease","authors":"P. Verma","doi":"10.1016/j.esmoop.2026.106147","DOIUrl":"10.1016/j.esmoop.2026.106147","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106147"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"26eP Trastuzumab deruxtecan in HER2-positive or ERBB2-mutated tumours: Real-world clinical practice data","authors":"N. Rodriguez Macias ,&nbsp;M.A. Cordero ,&nbsp;J. Montes González ,&nbsp;C. Saavedra Serrano ,&nbsp;M.L. Sanchez Lorenzo ,&nbsp;R. Sanchez Bayona ,&nbsp;J. Moreno ,&nbsp;L. Montero de la Fuente ,&nbsp;A. Gomez de Liano Lista ,&nbsp;D. Rodriguez Abreu ,&nbsp;P. Soto Rojas ,&nbsp;A. Estival Gonzalez ,&nbsp;E.G. Guadalupe ,&nbsp;N. Karani Narain ,&nbsp;J.A.R. Rodríguez García ,&nbsp;E.F. Llabres Valenti ,&nbsp;G. Visedo Ceballos ,&nbsp;M.G. Arevalo ,&nbsp;A. Ramchandani Vaswani","doi":"10.1016/j.esmoop.2026.106129","DOIUrl":"10.1016/j.esmoop.2026.106129","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106129"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}