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93P Advancing precision oncology in clinical practice: The impact of online education on the adoption and implementation of tumor-agnostic treatment
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104253
Z. Fiske , K. Peters , S. Dunn , A. Carothers , J. Habib , F. Lopez-Rios , A.M. Tsimberidou , V. Subbiah
{"title":"93P Advancing precision oncology in clinical practice: The impact of online education on the adoption and implementation of tumor-agnostic treatment","authors":"Z. Fiske , K. Peters , S. Dunn , A. Carothers , J. Habib , F. Lopez-Rios , A.M. Tsimberidou , V. Subbiah","doi":"10.1016/j.esmoop.2025.104253","DOIUrl":"10.1016/j.esmoop.2025.104253","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104253"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
32P Investigating the mechanistic pathways of a novel HDAC inhibitor in neuroblastoma
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104190
P. Pai , M.G. Shetty , Y.R. S R , K. Satyamoorthy , B.K. Sundara
{"title":"32P Investigating the mechanistic pathways of a novel HDAC inhibitor in neuroblastoma","authors":"P. Pai , M.G. Shetty , Y.R. S R , K. Satyamoorthy , B.K. Sundara","doi":"10.1016/j.esmoop.2025.104190","DOIUrl":"10.1016/j.esmoop.2025.104190","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104190"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
53P Exploring the clinical and therapeutic implications of non-hotspot mutations in POLE
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104212
M. Amann Arevalo , M.D.C. Garijo Martínez , I. Moreno , A. Manzano Fernández , P. Pérez Segura , A. Escudero , J. De La Macorra , J. Bartolomé Arcilla
{"title":"53P Exploring the clinical and therapeutic implications of non-hotspot mutations in POLE","authors":"M. Amann Arevalo , M.D.C. Garijo Martínez , I. Moreno , A. Manzano Fernández , P. Pérez Segura , A. Escudero , J. De La Macorra , J. Bartolomé Arcilla","doi":"10.1016/j.esmoop.2025.104212","DOIUrl":"10.1016/j.esmoop.2025.104212","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104212"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
62P Genome-wide CRISPR gain of function screen reveals resistance mechanisms and potential therapeutic targets in PDK1-inhibited PDAC
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104222
K. Fink , K. Sleiman , C. Veltkamp , F. Wang , M. Schmidt-Supprian , G. Schneider , D. Saur
{"title":"62P Genome-wide CRISPR gain of function screen reveals resistance mechanisms and potential therapeutic targets in PDK1-inhibited PDAC","authors":"K. Fink , K. Sleiman , C. Veltkamp , F. Wang , M. Schmidt-Supprian , G. Schneider , D. Saur","doi":"10.1016/j.esmoop.2025.104222","DOIUrl":"10.1016/j.esmoop.2025.104222","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104222"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
40O Phase I/Ib open-label study of an HER2-targeted T cell engager (TCE)‒SAR443216 in patients (pts) with advanced solid tumors: Intravenous (IV) dose-escalation results
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104199
E. Calvo , V. Moreno Garcia , D-Y. Oh , M.H. Ryu , E. Garralda , W-P. Chung , L-Y. Bai , K.I. Rojas Laimito , O. Yildirim , S. Masciari , G. Mi , L. Wang , D. Carene , S. Gailhac , R. Perez , P. Kanlikilicer , B. Buday , F. Rharbaoui , G. Abbadessa , E.E. Dumbrava
{"title":"40O Phase I/Ib open-label study of an HER2-targeted T cell engager (TCE)‒SAR443216 in patients (pts) with advanced solid tumors: Intravenous (IV) dose-escalation results","authors":"E. Calvo , V. Moreno Garcia , D-Y. Oh , M.H. Ryu , E. Garralda , W-P. Chung , L-Y. Bai , K.I. Rojas Laimito , O. Yildirim , S. Masciari , G. Mi , L. Wang , D. Carene , S. Gailhac , R. Perez , P. Kanlikilicer , B. Buday , F. Rharbaoui , G. Abbadessa , E.E. Dumbrava","doi":"10.1016/j.esmoop.2025.104199","DOIUrl":"10.1016/j.esmoop.2025.104199","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104199"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
17P KBA1413: An antibody derived from a cured AML patient, recognizes a unique glycoepitope shared by AML, MDS and several solid cancer cells
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104173
M. Kedde , V. Clerico Mosina , B. Pieters , B. Monica , K. Maijoor , E. Frankin , R. Schotte , A. Bakker , R. Roovers , M. Koslowski , S. Gullà
{"title":"17P KBA1413: An antibody derived from a cured AML patient, recognizes a unique glycoepitope shared by AML, MDS and several solid cancer cells","authors":"M. Kedde , V. Clerico Mosina , B. Pieters , B. Monica , K. Maijoor , E. Frankin , R. Schotte , A. Bakker , R. Roovers , M. Koslowski , S. Gullà","doi":"10.1016/j.esmoop.2025.104173","DOIUrl":"10.1016/j.esmoop.2025.104173","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104173"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
25P Targeting STAT3-mediated liver pathogenesis through novel RNA therapeutics strategies
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104182
J.Q. Eu , N.A. Mohamed Salleh , G.S.T. Soon , B-C. Goh , L.R. Kong
{"title":"25P Targeting STAT3-mediated liver pathogenesis through novel RNA therapeutics strategies","authors":"J.Q. Eu , N.A. Mohamed Salleh , G.S.T. Soon , B-C. Goh , L.R. Kong","doi":"10.1016/j.esmoop.2025.104182","DOIUrl":"10.1016/j.esmoop.2025.104182","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104182"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
69P Development and characterization of a terbium-161 radioconjugate for selective targeting of carbonic anhydrase IX in hypoxic colorectal tumors
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104228
C. Segers, K. Vermeulen, A. Coolkens, M. Crabbé, M. Ooms, T. Opsomer
{"title":"69P Development and characterization of a terbium-161 radioconjugate for selective targeting of carbonic anhydrase IX in hypoxic colorectal tumors","authors":"C. Segers, K. Vermeulen, A. Coolkens, M. Crabbé, M. Ooms, T. Opsomer","doi":"10.1016/j.esmoop.2025.104228","DOIUrl":"10.1016/j.esmoop.2025.104228","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104228"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
90P The journey of data: Why adjuvant cancer therapy trials go unpublished
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104250
H. Aufy , I.A. Qutob , A.S. Ashour , G. Ramzi Jabrieh , F.B.F. Alahmed , O.A. Mansy , A. Soliman , Y. El-Sherif
{"title":"90P The journey of data: Why adjuvant cancer therapy trials go unpublished","authors":"H. Aufy , I.A. Qutob , A.S. Ashour , G. Ramzi Jabrieh , F.B.F. Alahmed , O.A. Mansy , A. Soliman , Y. El-Sherif","doi":"10.1016/j.esmoop.2025.104250","DOIUrl":"10.1016/j.esmoop.2025.104250","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104250"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
41P Peptide-directed IL-2 drug delivery immunomodulates resident CD8+ T cells to improve pancreatic cancer survival
IF 7.1 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104200
G.P. Botta, I.H. Park, S. Abeynaike, D. Nishizaki
{"title":"41P Peptide-directed IL-2 drug delivery immunomodulates resident CD8+ T cells to improve pancreatic cancer survival","authors":"G.P. Botta, I.H. Park, S. Abeynaike, D. Nishizaki","doi":"10.1016/j.esmoop.2025.104200","DOIUrl":"10.1016/j.esmoop.2025.104200","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104200"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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