ESMO Open最新文献

{"title":"Gene testing and prognosis in post-operative recurrent non-small-cell lung cancer: subgroup analyses of WJOG15421L","authors":"T. Matsubara ,&nbsp;T. Sakamoto ,&nbsp;T. Takahama ,&nbsp;T. Yokoyama ,&nbsp;I. Yoshino ,&nbsp;H. Akamatsu ,&nbsp;M. Yamaguchi ,&nbsp;J. Baba ,&nbsp;T. Tokito ,&nbsp;M. Tachihara ,&nbsp;Y. Sato ,&nbsp;T. Takenaka ,&nbsp;K. Sugio ,&nbsp;M. Mori ,&nbsp;T. Takeuchi ,&nbsp;K. Okazuka ,&nbsp;H. Kenmotsu ,&nbsp;J. Fujimoto ,&nbsp;M. Shimokawa ,&nbsp;N. Yamamoto ,&nbsp;K. Nakagawa","doi":"10.1016/j.esmoop.2026.106890","DOIUrl":"10.1016/j.esmoop.2026.106890","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to investigate the status of biomarker testing and prognosis in patients with post-operative recurrent non-small-cell lung cancer (NSCLC).</div></div><div><h3>Patients and methods</h3><div>This retrospective multicenter study included 1500 patients with advanced or recurrent NSCLC from 29 institutions between July 2020 and June 2021. A post-operative recurrence subgroup analysis was carried out on 229 patients. The main focus was on the testing rate for biomarkers, including multigene testing. Survival analyses were also conducted.</div></div><div><h3>Results</h3><div>The median age of the study cohort was 74 years (range 40-92 years). Of the patients, 46.5% had stage I NSCLC, and 67% had adenocarcinoma. Median time from surgery to recurrence was 511 days, and 169 patients had distant metastases; 23% of the patients underwent rebiopsy to confirm recurrence. Multigene testing was conducted in 43.7% of the patients, and single-gene testing in 56.8%. Multigene testing was more frequent in cases with distant metastases (47%) compared with local recurrences (35%). No significant difference in testing success was observed between the resected preserved specimens and the rebiopsied recurrent specimens. Multigene testing was less likely if recurrence occurred &gt;3 years after surgery. Post-operative recurrent patients had better overall survival than advanced-stage patients in both the overall cohort and the driver-positive subgroup.</div></div><div><h3>Conclusions</h3><div>The rate of multigene testing in post-operative recurrent NSCLC cases was low despite the availability of sufficient surgical specimens. The further widespread adoption of multigene testing is one of the most critical challenges for improving resected patient outcomes along with recent advances in perioperative personalized medicine.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 4","pages":"Article 106890"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"71P Association between cytokine release syndrome, antitumor response, and overall survival in patients treated with T cell engagers: A retrospective study","authors":"I. Ruiz-Gutiérrez ,&nbsp;I. Matos Garcia ,&nbsp;A. Landa Magdalena ,&nbsp;M. Ponz-Sarvise ,&nbsp;I. Ortego Zabalza ,&nbsp;A. Chopitea Ortega ,&nbsp;A. Vilalta ,&nbsp;I. Eguren-Santamaria ,&nbsp;M.E. RodrÍguez-Ruiz ,&nbsp;E. Castanon Alvarez","doi":"10.1016/j.esmoop.2026.106212","DOIUrl":"10.1016/j.esmoop.2026.106212","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106212"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"128MO Impact of in-vitro diagnostic regulation (IVDR) implementation on authorization timelines and access to oncology clinical research","authors":"A. Matres Rojo ,&nbsp;N. Farràs ,&nbsp;P. Chiquillo ,&nbsp;M. Rotxes Costa ,&nbsp;C. Perez Alonso ,&nbsp;L. Cruz Ballús ,&nbsp;S. Vázquez Vinuesa ,&nbsp;E. Aliende ,&nbsp;L. Saucedo Martin ,&nbsp;E. Banus ,&nbsp;A. Almodovar ,&nbsp;L. Catalan ,&nbsp;A. Meire Barrio ,&nbsp;O. Padros ,&nbsp;A. Vivancos ,&nbsp;S. Aguilar Izquierdo ,&nbsp;J. Tabernero ,&nbsp;E. Felip ,&nbsp;A. Hernando Calvo ,&nbsp;E. Garralda","doi":"10.1016/j.esmoop.2026.106270","DOIUrl":"10.1016/j.esmoop.2026.106270","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106270"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"19P Design and evaluation of nanobodies targeting the human tumor protein TCTP","authors":"L.E. Martinez Hernandez,&nbsp;L.C.C. Triana Vidal,&nbsp;B. Calderón Pérez,&nbsp;L. Núñez Muñoz,&nbsp;R. Ruiz Medrano,&nbsp;B. Xoconostle Cazares","doi":"10.1016/j.esmoop.2026.106122","DOIUrl":"10.1016/j.esmoop.2026.106122","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106122"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"89O BMS-986504 with or without gemcitabine (GEM) + nab-paclitaxel (nab-P) in patients (pts) with pancreatic ductal adenocarcinoma (PDAC) and homozygous MTAP deletion (MTAP-del) from CA240-0007","authors":"B. George ,&nbsp;K. Leventakos ,&nbsp;M. Pelster ,&nbsp;J. Rodon Ahnert ,&nbsp;K. Papadopoulos ,&nbsp;A. Spira ,&nbsp;K.C. Arbour ,&nbsp;C.A. Perez ,&nbsp;H. Babiker ,&nbsp;P.A. Jänne ,&nbsp;R.M. Zuniga ,&nbsp;A.S. Paulson ,&nbsp;T. Bekaii-Saab ,&nbsp;S. Chandana ,&nbsp;M. Kamgar ,&nbsp;L. Engstrom ,&nbsp;A. Mazzei-Abba ,&nbsp;A. Cheong ,&nbsp;H. Shi ,&nbsp;J. Henry","doi":"10.1016/j.esmoop.2026.106231","DOIUrl":"10.1016/j.esmoop.2026.106231","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106231"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"106P Pharmacological targeting of the ME–NRF2 axis under oxidative stress conditions in A549 NSCLC cells","authors":"N. Alis Soyleyici ,&nbsp;S. Guler","doi":"10.1016/j.esmoop.2026.106248","DOIUrl":"10.1016/j.esmoop.2026.106248","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106248"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"64P Molecularly unselected immune-based versus non-immune-based trials: Outcomes in refractory metastatic castrate resistant prostate cancer (mCPRC) at Sarah Cannon Research Institute (SCRI) UK","authors":"K. Chandran ,&nbsp;H. Almarzouq ,&nbsp;Y.F. Zheng ,&nbsp;B. Kelly ,&nbsp;L. Kenehan ,&nbsp;A. Williams ,&nbsp;R. Grochot ,&nbsp;R. Amofa ,&nbsp;E. Fontana","doi":"10.1016/j.esmoop.2026.106205","DOIUrl":"10.1016/j.esmoop.2026.106205","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106205"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating baseline ctDNA-derived tumor metrics enhances risk stratification in HR-positive/HER2-negative advanced breast cancer: a real-world multicenter cohort study from Austria","authors":"N. Dobrić ,&nbsp;S.O. Hasenleithner ,&nbsp;C. Suppan ,&nbsp;E.V. Klocker ,&nbsp;D. Hlauschek ,&nbsp;R. Graf ,&nbsp;C. Beichler ,&nbsp;C. Albertini ,&nbsp;D. Egle ,&nbsp;D. Liu ,&nbsp;A.M. Starzer ,&nbsp;R. Bartsch ,&nbsp;T. Moser ,&nbsp;G. Rinnerthaler ,&nbsp;P.J. Jost ,&nbsp;E. Heitzer ,&nbsp;N. Dandachi ,&nbsp;M. Balic","doi":"10.1016/j.esmoop.2026.106939","DOIUrl":"10.1016/j.esmoop.2026.106939","url":null,"abstract":"<div><h3>Background</h3><div>Advances in endocrine therapies for hormone receptor (HR)-positive/HER2-negative advanced breast cancer (ABC) continue to transform care and significantly improve patient outcomes. However, the integration of molecular and clinical risk stratification into guiding individualized treatment selection remains a key challenge. We therefore evaluated whether the integration of baseline circulating tumor DNA (ctDNA)-derived tumor metrics enhances risk stratification among patients receiving early lines of treatment of HR-positive ABC in a real-world multicenter cohort of patients in Austria.</div></div><div><h3>Methods</h3><div>Patients with HR-positive/HER2-negative ABC treated at multiple Austrian centers were included. CtDNA was analyzed using a 77-gene panel (AVENIO ctDNA Expanded Kit). Tumor fraction (TFx) was estimated via two complementary approaches: untargeted aneuploidy assessment using mFAST-SeqS, and the highest variant allele frequency (hVAF) from the AVENIO assay. Somatic variants and single, binary, and three-level composite TFx metrics were assessed for their association with progression-free and overall survival (PFS, OS).</div></div><div><h3>Results</h3><div>We analyzed 225 ctDNA samples from 184 patients [128 before first-line (1L) and 76 before second-line (2L) treatment], including 40 paired samples. Overall TFx was low (median z-score 2.49; range −0.5-208.3), with higher levels in 2L, although the difference did not reach statistical significance (<em>P</em> = 0.058). In contrast, the hVAF was significantly higher in the 2L cohort (<em>P</em> = 0.007). Somatic variant burden was significantly increased in 2L (<em>P</em> &lt; 0.001), with notably more frequent <em>ESR1</em> mutations (26.7% versus 7.1% in 1L). Median PFS was 29.2 months in 1L and 6.0 months in 2L, while median OS was 57.3 months and 16.1 months, respectively. <em>TP53</em> and <em>ESR1</em> mutations, and all ctDNA-based metrics were significantly associated with PFS and OS, with a three-level composite ctDNA variable showing the highest prognostic discrimination.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate that integrating baseline ctDNA-derived TFx metrics with established clinical variables significantly improves risk stratification in HR-positive/HER2-negative ABC.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 4","pages":"Article 106939"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"54P ALOX5-driven lipid metabolism underlies therapy resistance via enhanced DNA repair","authors":"M. Li","doi":"10.1016/j.esmoop.2026.106160","DOIUrl":"10.1016/j.esmoop.2026.106160","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106160"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"120eP Exploring the balance between mitogenic activation and inhibition of cellular stress pathways in tumorigenic and non-tumorigenic cells","authors":"K.A.M. Torres,&nbsp;R. Wailemann,&nbsp;T.E.P. Torres,&nbsp;F. Montoni,&nbsp;H. Armelin","doi":"10.1016/j.esmoop.2026.106261","DOIUrl":"10.1016/j.esmoop.2026.106261","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106261"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}