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52eP Correlation of tumor size with cellular isolate yield in serous ovarian cancer as a predictive factor for ATMP manufacturing in TIL therapy 浆液性卵巢癌肿瘤大小与细胞分离物产率的相关性作为TIL治疗中ATMP制造的预测因素
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106157
Z. Usmial, M. Gutek, A. Biernacka, J. Marynowska
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引用次数: 0
60O First-in-human phase I evaluation of HCB301, a tri-specific SIRPα-PD-1-TGFβ fusion protein: Safety, pharmacokinetics, and multisystem immune activation 60O三特异性SIRPα-PD-1-TGFβ融合蛋白HCB301的首次人体I期评估：安全性、药代动力学和多系统免疫激活
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106201
J. Zhu , W. Edenfield , H. Tong , L. Sun , A. Liu , X. Hu , A. Yu , F. Mo , A. Luk
{"title":"60O First-in-human phase I evaluation of HCB301, a tri-specific SIRPα-PD-1-TGFβ fusion protein: Safety, pharmacokinetics, and multisystem immune activation","authors":"J. Zhu , W. Edenfield , H. Tong , L. Sun , A. Liu , X. Hu , A. Yu , F. Mo , A. Luk","doi":"10.1016/j.esmoop.2026.106201","DOIUrl":"10.1016/j.esmoop.2026.106201","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106201"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
117P Targeted compound screening for the exploration of actionable vulnerabilities in LUSC 117P针对LUSC可操作漏洞的靶向化合物筛选
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106258
A.T. Iovita , E. Isachesku , O. Zanoaga , L. Raduly , L. Budisan , C. Braicu , C. Ciocan , A.A. Tirpe , S. Strilciuc , A. Bender , I. Berindan-Neagoe
{"title":"117P Targeted compound screening for the exploration of actionable vulnerabilities in LUSC","authors":"A.T. Iovita , E. Isachesku , O. Zanoaga , L. Raduly , L. Budisan , C. Braicu , C. Ciocan , A.A. Tirpe , S. Strilciuc , A. Bender , I. Berindan-Neagoe","doi":"10.1016/j.esmoop.2026.106258","DOIUrl":"10.1016/j.esmoop.2026.106258","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106258"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
121eP New therapeutic proposal for breast cancer: Combination of mitogen with a cell stress inhibitor 乳腺癌的新治疗方案：有丝分裂原与细胞应激抑制剂联合使用
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106262
T.E.P. Torres, R. Wailemann, H. Armelin
{"title":"121eP New therapeutic proposal for breast cancer: Combination of mitogen with a cell stress inhibitor","authors":"T.E.P. Torres, R. Wailemann, H. Armelin","doi":"10.1016/j.esmoop.2026.106262","DOIUrl":"10.1016/j.esmoop.2026.106262","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106262"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
20P αTIGIT-guided IL-15 mimetics drive potent and safe antitumor immunity via rejuvenating tumor infiltrating T cells 20P α - tigit引导的IL-15模拟物通过激活肿瘤浸润的T细胞来驱动有效和安全的抗肿瘤免疫
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106123
Z. Yang, X. Liu, Y-X. Fu
{"title":"20P αTIGIT-guided IL-15 mimetics drive potent and safe antitumor immunity via rejuvenating tumor infiltrating T cells","authors":"Z. Yang, X. Liu, Y-X. Fu","doi":"10.1016/j.esmoop.2026.106123","DOIUrl":"10.1016/j.esmoop.2026.106123","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106123"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
104P Rb deficiency induces synthetic lethality with ATR and PKMYT1 1 co-inhibition in breast cancer cell lines and patient-derived xenografts 在乳腺癌细胞系和患者来源的异种移植物中，通过ATR和PKMYT1共抑制104P Rb缺乏诱导合成致死
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106246
K. Keyomarsi , X-T. Jiang , M-K. Chen , J. Lee , X. Rao , Y. Wang , L. Luo , J. Wang , K.K. Hunt
{"title":"104P Rb deficiency induces synthetic lethality with ATR and PKMYT1 1 co-inhibition in breast cancer cell lines and patient-derived xenografts","authors":"K. Keyomarsi , X-T. Jiang , M-K. Chen , J. Lee , X. Rao , Y. Wang , L. Luo , J. Wang , K.K. Hunt","doi":"10.1016/j.esmoop.2026.106246","DOIUrl":"10.1016/j.esmoop.2026.106246","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106246"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
73P Enhancing CAR T cell therapy through the epigenetic reprogramming of memory gene transcriptional circuits 通过记忆基因转录回路的表观遗传重编程增强CAR - T细胞治疗
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106214
F. De Santis , C. Fornasier , A. Indini , G. Nardo , F. De Braud , M. Di Nicola
{"title":"73P Enhancing CAR T cell therapy through the epigenetic reprogramming of memory gene transcriptional circuits","authors":"F. De Santis , C. Fornasier , A. Indini , G. Nardo , F. De Braud , M. Di Nicola","doi":"10.1016/j.esmoop.2026.106214","DOIUrl":"10.1016/j.esmoop.2026.106214","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106214"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
33P An agent-based learning model integrating sex differences in renal cell carcinoma 33P基于agent的肾细胞癌性别学习模型
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106137
A. Rizzo , E. Merelli , T. Taha , S. Buti , F. Massari , J. Molina Cerrillo , F.S.M. Monteiro , B.A. Maiorano , M. Santoni
{"title":"33P An agent-based learning model integrating sex differences in renal cell carcinoma","authors":"A. Rizzo , E. Merelli , T. Taha , S. Buti , F. Massari , J. Molina Cerrillo , F.S.M. Monteiro , B.A. Maiorano , M. Santoni","doi":"10.1016/j.esmoop.2026.106137","DOIUrl":"10.1016/j.esmoop.2026.106137","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106137"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
17P Structure-guided pi modulation of shark-derived VNARs enables pharmacokinetic control for theranostic applications 17P结构引导的鲨鱼源性VNARs的pi调节使治疗应用的药代动力学控制成为可能
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106120
K. Ott , G. Gunaratne , J. West , J. Gallant , J. Engle , A. Lebeau
{"title":"17P Structure-guided pi modulation of shark-derived VNARs enables pharmacokinetic control for theranostic applications","authors":"K. Ott , G. Gunaratne , J. West , J. Gallant , J. Engle , A. Lebeau","doi":"10.1016/j.esmoop.2026.106120","DOIUrl":"10.1016/j.esmoop.2026.106120","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106120"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
30P Multimodal transformers integrating shear wave elastography and tumor stiffness predict response to cancer therapy 整合剪切波弹性成像和肿瘤刚度的30P多模态变压器预测癌症治疗的反应
IF 8.3 2区 医学 Q1 ONCOLOGY
ESMO Open
Pub Date : 2026-04-01 DOI: 10.1016/j.esmoop.2026.106134
C. Voutouri , S. Georgiou , T. Stylianopoulos
{"title":"30P Multimodal transformers integrating shear wave elastography and tumor stiffness predict response to cancer therapy","authors":"C. Voutouri , S. Georgiou , T. Stylianopoulos","doi":"10.1016/j.esmoop.2026.106134","DOIUrl":"10.1016/j.esmoop.2026.106134","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"11 ","pages":"Article 106134"},"PeriodicalIF":8.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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