European Journal of Integrative Medicine最新文献

{"title":"Clinical efficacy and safety of Shensong Yangxin capsule-antiarrhythmic drug combination for paroxysmal atrial fibrillation: A meta-analysis of randomized controlled trials","authors":"Xinfu Cao ,&nbsp;Zhenhua Gu ,&nbsp;Yi Sun ,&nbsp;Yuqiao Chen ,&nbsp;Chao Tang ,&nbsp;Hongwen Yu ,&nbsp;Xiaolong Li","doi":"10.1016/j.eujim.2023.102320","DOIUrl":"10.1016/j.eujim.2023.102320","url":null,"abstract":"<div><h3>Introduction</h3><p>Shensong Yangxin Capsule (SSYX) is a famous traditional Chinese patent medicine produced in China for the treatment of arrhythmia. Recently, China released a series of randomized controlled trials (RCTs) using SSYX combined with antiarrhythmic drugs (ADs) for the treatment of paroxysmal atrial fibrillation (PAF). However, these RCTs have not been systematically evaluated. The purpose of this review was to assess the effectiveness and safety of SSYX combined with AD (SSYX-AD) in the treatment of PAF.</p></div><div><h3>Methods</h3><p>RCTs of SSYX-AD in the treatment of PAF were collected by searching the Chinese Knowledge Infrastructure Database (CNKI), PubMed, Chinese Scientific Journal Database (VIP), Wanfang Database, Cochrane Library, China Biomedical Database Network (CBM), Excerpt Medica Database (EMBASE), and clinical trial platforms such as the UK National Research Registry (NRR), the World Health Organization Clinical Trial Registry (ICTRP), and the Chinese Clinical Trial Registry (CCTR) from its creation until July 1, 2023. The primary outcome was the effective rate. The secondary outcomes were the frequency of atrial fibrillation (FAF), left atrial diameter (LAD), P wave dispersion (PWD), adverse reactions (ADRs), left ventricular ejection fraction (LVEF), and sinus rhythm maintenance rate (SRMR). The quality assessment of RCTs was completed using the Cochrane risk-of-bias tool, and the meta-analysis was completed using RevMan 5.3 software. This review was conducted in accordance with the PROSPERO-registered protocol (number: CRD42023413442).</p></div><div><h3>Results</h3><p>The review included a total of 29 RCTs including 2766 patients. The review showed that the SSYX-AD group had more advantages than AD group in improving the effective rate [RR=1.18; 95 % CI (1.12, 1.24); <em>p</em> &lt; 0.01], LVEF [MD =3.40; 95 % CI (0.91, 5.88); <em>p</em> = 0.007], SRMA [RR=1.38; 95 % CI (1.22, 1.57); <em>p</em> &lt; 0.01], and was superior to AD alone in reducing the FAF [MD=2.89; 95 % CI (1.57, 4.21); <em>p</em> &lt; 0.01], LAD [MD=2.44; 95 % CI (0.85, 4.03); <em>p</em> &lt; 0.01], PWD [MD = 4.90; 95 % CI (2.81, 6.99); <em>p</em> &lt; 0.05], and ADRs [RR=0.41; 95 % CI (0.29, 0.58); <em>p</em> &lt; 0.01].</p></div><div><h3>Conclusions</h3><p>Despite the apparently positive outcomes presented, due to the low methodological quality of the included RCTs there was insufficient evidence to recommend routine use of SSYX-AD for PAF. The aggregate effect must be validated by additional well-designed, adequately sampled, and methodologically sound clinical studies.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"65 ","pages":"Article 102320"},"PeriodicalIF":2.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Shengmai injection for chronic cor pulmonale: A systematic review with meta-analysis and trial sequential analysis of 31 randomized controlled trials","authors":"Xunxun Yuan ,&nbsp;Xianjie Feng ,&nbsp;Jun He ,&nbsp;Sheng Xu ,&nbsp;Xu Zhou ,&nbsp;Lihua Wang","doi":"10.1016/j.eujim.2023.102318","DOIUrl":"10.1016/j.eujim.2023.102318","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to systematically evaluate the efficacy and safety of Shengmai injection (<em>Radix ginseng, Radix ophiopogonis,</em> and <em>Fructus Schisandrae chinensis</em>) as an adjunct to conventional medicine in the treatment of chronic cor pulmonale.</p></div><div><h3>Methods</h3><p>A search of ten databases was conducted up to March 27, 2023, to identify randomized controlled trials that assessed the efficacy of Shengmai injection plus conventional medicine versus conventional medicine alone in the treatment of chronic cor pulmonale. Meta-analysis was performed using RevMan version 5.4, with risk ratios (RRs), mean differences (MDs), and 95 % confidence intervals (CIs) used as effect measures. Trial sequential analyses were conducted to quantify the statistical reliability of the data in the studies.</p></div><div><h3>Results</h3><p>A total of 31 studies involving 3,036 patients were included in the meta-analysis. The results showed that Shengmai injection combined with conventional therapies significantly improved the response to treatment (RR 1.24, CIs 1.19 to 1.29) as well as heart function (e.g., left ventricular ejection fraction: MD 8.14 % [CIs 2.33 to 13.95]; right ventricular ejection fraction: MD 8.51 % [CIs 3.61 to 13.41], stroke volume: MD 12.38 mL [CIs 4.80 to 19.96], cardiac output: MD 0.35 L/min, [CIs 0.19 to 0.50], cardiac index: MD 0.45 L/min·m², [CIs 0.19 to 0.72]), blood gas indicators (SaO₂: MD 4.18 % [CIs 3.12 to 5.25], PaO₂: MD 5.63 mmHg [CIs 4.26 to 7.00]), and lung function (FEV₁: MD 0.40 L [CIs 0.26 to 0.53], FEV₁/FVC: MD 10.10 % [CIs 7.43 to 12.77]) in patients with cor pulmonale. Additionally, no significant improvement was observed in creatine kinase isoenzyme- myocardial band or plasma viscosity compared with the controls. Two cases (4 %) of mild adverse events (dry mouth) possibly related to Shengmai injection were reported, but no serious adverse events were observed.</p></div><div><h3>Conclusions</h3><p>Shengmai injection may be an effective supplemental therapy for chronic cor pulmonale, potentially improving treatment response, heart and lung functioning, blood gas analysis, and hemorheological indicators, with an acceptable safety profile. However, the risk of selection bias and high heterogeneity in some studies highlight the need for further multicenter, large-sample randomized controlled trials to validate these findings.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"65 ","pages":"Article 102318"},"PeriodicalIF":2.5,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187638202300094X/pdfft?md5=a2a653895ad67f5c3f56c0a2df40b625&pid=1-s2.0-S187638202300094X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of drivers and affecting factors in the future of Persian medicine: The cross-impact analysis method","authors":"Mohammad Hossain Mehrolhassani ,&nbsp;Mohammad Setayesh ,&nbsp;Vahid Yazdi-Feyzabadi ,&nbsp;Rohaneh Rahimisadegh","doi":"10.1016/j.eujim.2023.102316","DOIUrl":"10.1016/j.eujim.2023.102316","url":null,"abstract":"<div><h3>Introduction</h3><p>Persian medicine is a holistic medical school with deep roots. It has a high educational, research, and therapeutic capacity and has been the focus of Iran's general health policies in recent years. Futures studies aid policymakers and health managers in creating normative scenarios and developing action plans using various techniques. This study aimed to identify important drivers and factors that affect the future of the Persian medicine system.</p></div><div><h3>Method</h3><p>This qualitative research was conducted with a futures studies approach, using the Cross-Impact Analysis (CIA) in three main steps. The first and second steps were conducted using interviews and focus group discussions. In the first step, 15 semi-structured interviews were conducted with Persian medicine experts to identify all factors affecting the future of Persian medicine. In the second step, we held three focus group discussions with 9 interviewees from step one with national-level influence to determine the influence and dependence of each factor. The third step was performed using the matrix CIA and MICMAC to identify the key factors affecting the future of Persian medicine.</p></div><div><h3>Results</h3><p>Sixty five variables affecting the future of Persian medicine were identified, 36 related to the health system, and 29 to external factors. Factors such as globalization, knowledge-based economy, the spread of non-communicable and chronic diseases, as well as people's views and attitudes towards Persian medicine, are considered key drivers and variables that will affect the future of the Persian medicine system. The Iranian development plans as a two-dimensional and risk factor are crucial in establishing Persian medicine.</p></div><div><h3>Conclusion</h3><p>The future of the Persian medicine system is relatively stable. The pattern of the Iranian development plans is considered the most important two-faceted factor as a risk factor in the establishment of the Persian medicine system. It is suggested that the position of the Persian medicine system in the Iranian development plans be made more prominent.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"65 ","pages":"Article 102316"},"PeriodicalIF":2.5,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Chinese herbal medicine on pregnancy outcomes of women with PCOS undergoing in vitro fertilization and embryo transfer: A retrospective cohort study","authors":"Minchen Dai ,&nbsp;Biwei Shi ,&nbsp;Xian Zhang ,&nbsp;Yinger Gu ,&nbsp;Fangfang Wang ,&nbsp;Jue Zhou ,&nbsp;Fan Qu","doi":"10.1016/j.eujim.2023.102317","DOIUrl":"10.1016/j.eujim.2023.102317","url":null,"abstract":"<div><h3>Introduction</h3><p>Chinese herbal medicine is widely used for treating polycystic ovary syndrome (PCOS). The present study aimed to explore the effects of Bu-Shen-Jian-Pi Formula, a Chinese herbal medicine formula, on the pregnancy outcomes of women with PCOS undergoing <em>in vitro</em> fertilization and embryo transfer (IVF-ET) based on a retrospective cohort study.</p></div><div><h3>Methods</h3><p>One hundred and forty-six females with PCOS undergoing IVF-ET were included in the study from Women's Hospital, School of Medicine, Zhejiang University between July 2016 and June 2021, of whom 73 patients received Bu-Shen-Jian-Pi Formula treatment for 12 weeks before IVF-ET, while the other 73 did not. The clinical data were collected from the medical records of the included patients. Bone morphogenetic protein 15 (BMP15) and leukemia inhibitory factor levels in the follicular fluids were detected.</p></div><div><h3>Results</h3><p>After the treatment of Bu-Shen-Jian-Pi Formula, women with PCOS undergoing IVF-ET exhibited significant improvement in the fertilization (P&lt;0.05), good-quality embryo (P&lt;0.01), clinical pregnancy (P&lt;0.01), and live birth (P&lt;0.01) rates, and single birthweight in newborns (P&lt;0.05). The expression levels of BMP15 in the follicular fluids of the women with PCOS were significantly increased after Bu-Shen-Jian-Pi Formula treatment (P&lt;0.05).</p></div><div><h3>Conclusion</h3><p>This study provided preliminary evidence of a significant association of Bu-Shen-Jian-Pi Formula treatment with improved pregnancy outcomes in women with PCOS undergoing IVF-ET, partly through increasing BMP15 levels in the follicular fluids.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"65 ","pages":"Article 102317"},"PeriodicalIF":2.5,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practice toward complementary alternative medicine in the UAE: A cross- sectional study","authors":"Yousef Aljawarneh,&nbsp;Lubna Rajab,&nbsp;Amani Alzeyoudi,&nbsp;Amnah Alzeyoudi,&nbsp;Amira Ibrahim,&nbsp;Noura Alnaqbi,&nbsp;Salha Alkaabi","doi":"10.1016/j.eujim.2023.102310","DOIUrl":"10.1016/j.eujim.2023.102310","url":null,"abstract":"<div><h3>Introduction</h3><p>Complementary and Alternative Medicine (CAM) encompasses utilization of traditional approaches in treating illnesses. The literature on CAM in the United Arab Emirates (UAE) shows varying awarness and practice. This study aimed to assess the knowledge, attitude, and practice towards CAM in the UAE.</p></div><div><h3>Methods</h3><p>The study utilized a cross-sectional design and collected data between January and March 2023 from adults in the UAE. Using convenience sampling, participants were invited to participate from public areas. A total of 964 individuals participated in the study by filling the survey electronically. Data were collecting using the CAM knowledge, attitude and practice (KAP) questionnaire. This study received ethical approval from Research Ethics and Integrity Committee at the Higher Colleges of Technology.</p></div><div><h3>Results</h3><p>The mean age of the participants was 31.32 years (+-10.66). The majority of the participants were Emirati (89.5 %), female (71.6 %), married (54.4 %) and held a bachelor's degree (40.4 %). Data on CAM knowledge showed that 66.7 % of the participants recognized CAM, mostly from family and friends (38 %). More than half (56.5 %) of the participants recognized the types of CAM, with Hijama as the most well known type. The majority of the participants (80.1 %) had a positive attitude toward CAM practice. Separated participants were 3.187 times less likely to exhibit positive attitude toward CAM than single participants (OR = -3.187., 95 %CI [.005, 0.345]) and Muslims were 3.517 times more likely to exhibit positive attitude toward CAM (OR = -3.517., 95 %CI [4.717, 240.673]). Moreover, 39.3 % of the participants tried CAM mostly to relieve pain (54.8 %). There was a significant correlation between age and knowledge about CAM (<em>r</em> = 0.147, <em>p</em> &lt; 0.001) and between knowledge and attitude toward CAM (<em>r</em> = 0.149, <em>p</em> &lt; 0.001). There was a significant correlation between attitude toward CAM and knowledge about Hijama (<em>r</em> = 0.136, <em>p</em> &lt; 0.001), acupuncture (<em>r</em> = 0.192, <em>p</em> &lt; 0.001), dietary supplements (<em>r</em> = 0.180, <em>p</em> &lt; 0.001), and herbal medicine (<em>r</em> = 0.161, <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>In the UAE, there is considerable knowledge and acceptance of CAM. Recommendations are geared toward the involvement of healthcare professionals in CAM prescription and control. Community awareness about CAM is recommended to bridge the gap between safety, risks and benefits.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"64 ","pages":"Article 102310"},"PeriodicalIF":2.5,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135411543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study of reporting guidelines for clinical studies in Traditional Chinese Medicine","authors":"Yuting Duan ,&nbsp;Zhirui Xu ,&nbsp;Pinge Zhao ,&nbsp;Juexuan Chen ,&nbsp;Yanfang Ma ,&nbsp;Lin Yu","doi":"10.1016/j.eujim.2023.102315","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102315","url":null,"abstract":"<div><h3>Introduction</h3><p>Reporting guidelines (RGs) provide the minimum information for inclusion to ensure that research reports can be understood by readers, reproduced or otherwise utilized by other researchers, or guide decisions by clinicians. The Reporting Guidelines for Clinical Studies in Traditional Chinese Medicine (RGCS-TCM) were established to guide the development of reporting standardization of clinical studies in Traditional Chinese Medicine (TCM). However, the characteristics and methodological quality of existing RGCS-TCM are yet to be investigated. We therefore performed a cross-sectional study to identify and evaluate the adequacy of RGCS-TCM and propose recommendations to optimize the development standards and future directions for RGCS-TCM.</p></div><div><h3>Methods</h3><p>Seven databases including MEDLINE, Excerpta Medica Database (EMBASE), the Allied and Complementary Medicine Database (AMED), Chinese Biomedical Literature Service System (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data and VIP Chinese Medical Journal Database, the EQUATOR network website, tracking references to included studies, and Google Scholar were searched up to 20^th Oct 2023 for RGCS-TCM. The characteristics of included RGCS-TCM were summarized. The methodological quality of included RGCS-TCM were critically appraised.</p></div><div><h3>Results</h3><p>Thirty published RGCS-TCM and six registered (under development) RGCS-TCM for different types of studies were included. Nine RGCS-TCM did not use a consensus method and lacked a consensus process, and fourteen RGCS-TCM failed to retrieve and use existing relevant evidence and lacked preliminary systematic reviews. Thirteen RGs had a relatively complete research and development process, which met the 3 basic criteria for determining high-quality RGs. Most RGCS-TCM reported the details of 1) rationale of TCM (10/15, 66.7 %), 2) reason for selected certain type of TCM intervention (9/15, 60.0 %), 3) diagnosis of TCM conditions (9/15, 60.0 %), 4) details about the intervention and its controls (13/15, 86.7 %), 5) dynamic changes of Pattern Differentiation and Treatment (2/15, 13.3 %), 6) outcome assessment specifically linked with TCM (8/15, 53.3 %), and 7) potential side effects related to TCM (4/15, 26.7 %).</p></div><div><h3>Conclusion</h3><p>There are opportunities to rationalise and improve the quality of existing RGCS-TCM and reduce research waste. Further research is indicated to investigate the barriers and facilitators for optimizing the development and application of RGCS-TCM.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"64 ","pages":"Article 102315"},"PeriodicalIF":2.5,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382023000914/pdfft?md5=03380b6d5619edc9da081b88be3597be&pid=1-s2.0-S1876382023000914-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92028700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complex systems, complex practice, complex outcomes: A call for the development of complexity-informed implementation models (CIIM) for traditional, complementary, and integrative medicine.","authors":"Kim D. Graham,&nbsp;Hope Foley,&nbsp;Jon Adams,&nbsp;Amie Steel","doi":"10.1016/j.eujim.2023.102314","DOIUrl":"10.1016/j.eujim.2023.102314","url":null,"abstract":"<div><h3>Introduction</h3><p>Implementation science is the vehicle for ensuring that research evidence informs and shapes clinical practice. However, implementation models structured along linear and mechanistic lines are not necessarily aligned with the complexity of clinical practice. In this article we explore the development and value of a complexity informed implementation model primarily for use in traditional, complementary, and integrative medicine.</p></div><div><h3>Discussion</h3><p>Conventional linear mechanistic models of knowledge translation may be insufficient to address the needs of real-life clinical practice. Existing implementation models may pose particular challenges for use in traditional, integrative, and complementary systems of medicine due to their holistic orientation and perspective of human organisms as whole complex systems nested within other complex systems. This paper discusses how a complexity informed implementation model, non-linear in nature and founded on iterative processes, may better reflect the complex nature of the traditional, integrative, and complementary medicine clinical encounter and patient as a complex adaptive system.</p></div><div><h3>Conclusion</h3><p>The emergence of complexity science provides an opportunity to re-imagine implementation models and processes to support the translation of evidence into traditional, complementary, and integrative systems of medicine. We propose a complexity-informed implementation model to better meet the complex needs of real-life clinical practice.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"64 ","pages":"Article 102314"},"PeriodicalIF":2.5,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135410125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of traditional medicinal plants used to treat acne vulgaris in Türkiye","authors":"Fatma Sarı ,&nbsp;Zeynep Büşra Erarslan","doi":"10.1016/j.eujim.2023.102305","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102305","url":null,"abstract":"<div><h3>Introduction</h3><p>Acne vulgaris is one of the most common dermatological disorders, especially in adolescents. This study aimed to review medicinal plants used in the treatment of acne vulgaris in Türkiye which have comprehensive usage information.</p></div><div><h3>Methods</h3><p>Ethnobotanical studies conducted in Türkiye from 1990 to 2023 were identified through PubMed, Sciencedirect, Scopus, Google Scholar, and YOK National Thesis Center databases using standard keywords. Articles published in peer-reviewed journals, congress proceedings, and dissertations (gray literature) were included. The scientific, family, and local names; parts used; and the methods of preparation and application were extracted from 56 ethnobotanical studies. The most cited plant families, the most cited plant taxa, and the most frequently used plant parts were determined.</p></div><div><h3>Results</h3><p>In total, 84 taxa belonging to 67 genera and 44 families were identified as medicinal plants used to treat acne vulgaris. The families with the highest number of plants were Asteraceae (9 taxa), Rosaceae (9 taxa), Amaryllidaceae (8 taxa), Brassicaceae (3 taxa), Hypericaceae (3 taxa), Lamiaceae (3 taxa), Papaveraceae (3 taxa), and Plantaginaceae (3 taxa). The most frequently cited medicinal plants and their corresponding number of references were <em>Urtica dioica</em> L. (7), <em>Juglans regia</em> L. (7), <em>Laurus nobilis</em> L. (5), <em>Plantago major</em> L. (5), and <em>Malva sylvestris</em> L. (4). It was determined that the leaves were the most frequently used parts of the medicinal plants, accounting for 36 %. Infusion (29 %) was the most commonly used preparation method. Furthermore, bioactivity studies of the most cited plants were also reviewed to evaluate their efficacy in acne vulgaris.</p></div><div><h3>Conclusions</h3><p>This review has identified novel herbal products which may have potential for acne vulgaris treatment, although more preclinical and clinical studies are needed to confirm their activities.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"64 ","pages":"Article 102305"},"PeriodicalIF":2.5,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92028698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning-based evaluation of application value of traditional Chinese medicine clinical index and pulse wave parameters in the diagnosis of polycystic ovary syndrome","authors":"Jiekee Lim ,&nbsp;Jieyun Li ,&nbsp;Xiao Feng ,&nbsp;Lu Feng ,&nbsp;Xinang Xiao ,&nbsp;Yumo Xia ,&nbsp;Yiqin Wang ,&nbsp;Lin Qian ,&nbsp;Hong Yang ,&nbsp;Zhaoxia Xu","doi":"10.1016/j.eujim.2023.102311","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102311","url":null,"abstract":"<div><h3>Introduction</h3><p>Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women that often leads to ovulatory infertility. This study aims to establish and validate an effective predictive model for PCOS and to explore the correlation of features between patients with irregular menstruation and those with PCOS, using pulse wave parameters and traditional Chinese medicine (TCM) clinical indices.</p></div><div><h3>Methods</h3><p>From August 2018 to January 2022, women with irregular menstruation were enrolled in this study. Subjects who met the inclusion criteria were categorized into PCOS and non-PCOS groups based on diagnostic criteria. Pulse wave parameters and TCM clinical indices were collected by two medical professionals. After data cleaning, recursive feature elimination with cross-validation (RFECV) was used for feature selection. Four supervised machine learning classifiers were used to build PCOS prediction models, including Extra Trees (ET), Random Forest (RF), Extreme Gradient Boosting (XGB/XGBoost), and Support Vector Machine (SVM). The SHapley Additive exPlanation (SHAP) values based on the optimal model were visualized for further feature explanation.</p></div><div><h3>Results</h3><p>A total of 450 women with irregular periods were enrolled in the study, consisting of 294 patients with PCOS and 156 without PCOS. Based on RFECV, 31 features, including 12 pulse parameters and 19 TCM clinical indices, were selected for building prediction models. Using pulse and TCM clinical index was superior to using pulse parameters or TCM clinical index alone in prediction. SVM achieved the best PCOS prediction results (accuracy=0.837, AUC=0.878, F1 score=0.878). For pulse parameters, lower values of right As, right h4, left h1, left h3, left h5, left w/t, and higher right t5 showed an obvious positive PCOS predictive effect. Women with PCOS were more likely to experience delayed menstruation, negative emotions, a slightly jelly-like menstrual texture, higher BMI, and a TCM assessment of greasy tongue coating.</p></div><div><h3>Conclusion</h3><p>A PCOS prediction model based on the SVM algorithm was established and verified as the best model for distinguishing between patients with PCOS and patients without PCOS with irregular menstruation. The new prediction model that uses pulse wave parameters and TCM clinical indices offers a non-invasive and cost-effective way to diagnose PCOS, and the model provides objective evidence for TCM diagnosis.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"64 ","pages":"Article 102311"},"PeriodicalIF":2.5,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382023000872/pdfft?md5=660b2fc308f71cadee2c86cf5a0eb5a7&pid=1-s2.0-S1876382023000872-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92028699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bloodletting therapy for primary headache: A systematic review and meta-analysis of randomized controlled trials","authors":"Shuai Dong,&nbsp;Yi-Ying Wang,&nbsp;Bo Li,&nbsp;Shi-Bing Liang,&nbsp;Hui-Juan Cao","doi":"10.1016/j.eujim.2023.102312","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102312","url":null,"abstract":"<div><h3>Introduction</h3><p>Headache is one of the most common symptoms worldwide. This systematic review aimed to assess the effectiveness and safety of bloodletting therapy (BLT) for primary headache.</p></div><div><h3>Methods</h3><p>Four English databases, four Chinese databases and five trials registries were searched from inception to 2^nd Sep 2022. Randomized controlled trials which compared BLT to no treatment or drugs for primary headache were included. BLT as adjunctive treatment of drugs or acupuncture was also included. Two authors extracted data and assessed the quality of trials through the Cochrane risk of bias tool 2.0 independently. Pain intensity was the primary outcome (e.g. Visual analogue scale, VAS). Meta-analysis (using RevMan 5.4.1) with random effect model was conducted when there was no serious statistical heterogeneity among trials (<em>I</em>²≤75 %). GRADE was used to assess the certainty of evidence.</p></div><div><h3>Results</h3><p>Seventeen trials involving 1123 participants were included. Types of BLT included pricking BLT, wet cupping and bloodletting puncture with plum-blossom needle. The most frequently used BLT acupoint was <em>Tai Yang</em>. Type of comparisons included BLT vs. drugs (<em>n</em> = 3), BLT plus drugs vs. drugs (<em>n</em> = 4) and BLT plus acupuncture vs. acupuncture (<em>n</em> = 10). All included trials were assessed as \"high risk of bias\". Results showed that BLT plus rizatriptan benzoate tablets was superior to drug alone in reducing VAS (Mean Difference (MD)=-2.07 cm, 95 % Confidence Interval (CI) -2.65 cm to -1.50 cm, <em>P</em>&lt;0.00001) and increasing the number of patients with more than half pain relief (by 39 %). BLT plus acupuncture was superior to acupuncture alone (MD=-0.80 cm, 95 % CI -1.20 cm to -0.41 cm, <em>P</em>&lt;0.00001) for pain relief. However, no difference was found between BLT and drugs on decreasing VAS. The certainty of the overall evidence is very low mainly due to the poor methodological quality and high heterogeneity among trials.</p></div><div><h3>Conclusion</h3><p>Very low certainty evidence suggests that BLT combined with acupuncture or drugs may be more effective in relieving pain of primary headache and other concomitant symptoms. Current evidence does not support confirmatory conclusions about the safety of BLT.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"64 ","pages":"Article 102312"},"PeriodicalIF":2.5,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92045550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}