European Journal of Integrative Medicine最新文献

{"title":"Efficacy, safety, and pharmacological mechanism of Suxiao Jiuxin Pill in acute coronary syndrome: A systematic review and network pharmacology analysis","authors":"Xinyue Hu ,&nbsp;Yaoyuan Liu ,&nbsp;Opoku Bonsu Francis ,&nbsp;Jingwen Guo ,&nbsp;Huiwen Feng ,&nbsp;Ruiqiao Li ,&nbsp;Ling Leng ,&nbsp;Wentai Pang ,&nbsp;Qilong Wang","doi":"10.1016/j.eujim.2025.102524","DOIUrl":"10.1016/j.eujim.2025.102524","url":null,"abstract":"<div><h3>Introduction</h3><div>Suxiao Jiuxin Pill (SJP), a patented Chinese medicine, is used to treat various cardiovascular diseases, including acute coronary syndrome (ACS). Nonetheless, substantial evidence validating the efficacy and safety of SJP, as well as elucidating its underlying mechanisms in ACS treatment, is lacking. In this study, a systematic review and network pharmacology approach were employed to evaluate the efficacy and safety of combining SJP with conventional treatment (CT) for ACS and to explore the potential mechanisms.</div></div><div><h3>Methods</h3><div>A systematic search of eight electronic databases was conducted to retrieve relevant randomized controlled trials (RCTs) which evaluated the efficacy and safety of SJP combined with CT for treating ACS. The Cochrane risk-of-bias tool for RCTs version 2.0 was used to assess the risk of bias. The fixed-effects model or the random-effects model was determined based on the significance of the statistical heterogeneity and clinical heterogeneity. Risk ratios and mean differences were calculated for binary variables and continuous variables, respectively, based on a 95 % confidence interval. Finally, network pharmacology analysis was used to explore the underlying mechanisms of action of SJP in ACS treatment.</div></div><div><h3>Results</h3><div>A total of 39 RCTs involving 4265 patients were included. The intervention group showed significant improvements, including a lower incidence of myocardial infarction, left heart failure, and sudden death, compared to the control group. The intervention group also demonstrated enhanced clinical efficacy, improved electrocardiogram results, fewer angina attacks, and shorter duration of angina. No significant differences in the incidence of adverse events were found between the intervention and control groups. Network pharmacology identified ferulic acid, caffeic acid, and scopoletin as the active ingredients responsible for the observed therapeutic effects of SJP. Additionally, potential therapeutic targets such as GSK3B, PRKCA, and EGFR, as well as other pathways related to the HIF-1, IL-17, and TNF signaling pathways, were identified as potential mechanisms regulated by SJP.</div></div><div><h3>Conclusion</h3><div>This study indicates that a combination therapy of SJP and CT may provide benefits for patients with ACS by reducing cardiovascular events, improving myocardial ischemia, and alleviating cardiac symptoms with favorable safety. These findings also suggest that the effects of SJP on ACS involve a multi-target, multi-component, and multi-pathway mechanism.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102524"},"PeriodicalIF":1.9,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Tai Chi and resistance exercise on fatigue in patients with ulcerative colitis: A randomized clinical trial","authors":"Yu Zhou ,&nbsp;Tengteng Ding ,&nbsp;Ranran Qiao ,&nbsp;Ping Zhang ,&nbsp;Hui Li ,&nbsp;Qiong Liu","doi":"10.1016/j.eujim.2025.102519","DOIUrl":"10.1016/j.eujim.2025.102519","url":null,"abstract":"<div><h3>Introduction</h3><div>Fatigue is common and burdensome in patients with ulcerative colitis (UC), yet pharmacological treatments offer limited relief. Exercise is gaining attention as a non-pharmacological strategy, and resistance training is increasingly recommended. However, Tai Chi—a traditional Chinese exercise—has not yet been evaluated in this population. This study compared the effects of Tai Chi and resistance training on multiple outcomes in patients with UC.</div></div><div><h3>Methods</h3><div>This single-center, evaluator-blind, three-arm randomized clinical trial block-randomized 75 patients with UC to 12 weeks of Tai Chi or resistance training and a control group involving standard treatment and care with general exercise advice. Eligible participants had fatigue (Multidimensional Fatigue Inventory score ≥ 40) and were in remission or had mild-to-moderate disease activity (Modified Mayo score ≤ 10). The primary outcome was fatigue, secondary outcomes included handgrip strength (HGS), skeletal muscle mass index (SMI), sleep quality, anxiety, depression, and health-related quality of life, all strongly associated with fatigue.</div></div><div><h3>Results</h3><div>The three groups showed significant differences in total fatigue and in general, physical, and mental fatigue subdimensions. Compared with the control group, fatigue improved in both the Tai Chi group (mean difference:8.90 [95 % confidence interval [CI], -15.11 to -2.69]) and the resistance training group (mean difference:7.00 [95 % CI, -13.16 to -0.84]), with no significant differences between them. However, between the two interventions, Tai Chi showed numerically greater improvements in anxiety, depression, and emotional function, while resistance training led to greater improvements in HGS (mean difference: 7.50 [95 % CI, 2.37 to 12.63]) and SMI (mean difference: 0.54 [95 % CI, 0.01 to 1.08]). No adverse events occurred, except for one case of mild abdominal discomfort in the resistance training group, which resolved with rest.</div></div><div><h3>Conclusions</h3><div>Both Tai Chi and resistance training effectively reduced fatigue and improved related outcomes in UC patients. Tai Chi may be more beneficial for psychological symptoms, while resistance training showed greater improvements in physical strength. Given their complementary advantages and safety, both may serve as valuable non-pharmacological options in UC management. Future studies should explore their integration into long-term, multimodal treatment strategies.</div></div><div><h3>Registration</h3><div>ChiCTR2300071289.</div></div><div><h3>Funding</h3><div>None.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102519"},"PeriodicalIF":1.9,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal protective effects of Tongxinluo capsule for hypertensive nephropathy: A systematic review and meta-analysis","authors":"Xuan Song ,&nbsp;Xinkang Li ,&nbsp;Luda Feng ,&nbsp;Xinyi Shi ,&nbsp;Rufan Xu ,&nbsp;Ning Liang ,&nbsp;Boyang Li ,&nbsp;Boya Zhang ,&nbsp;Jianguo Qin","doi":"10.1016/j.eujim.2025.102521","DOIUrl":"10.1016/j.eujim.2025.102521","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertensive nephropathy (HN) remains the second leading cause of end-stage renal disease. Tongxinluo capsule is commonly used in the treatment of HN under the condition that there is no specific therapy. We aimed to assess the efficacy and safety of Tongxinluo capsule for HN.</div></div><div><h3>Methods</h3><div>We systematically searched Pubmed, Embase, the Cochrane Library, China National Knowledge Infrastructure, Chinese Scientific Journals Database of VIP INFORMATION, Wanfang Data, and SinoMed from their inception to December 2024. Randomized controlled trials (RCTs) comparing the efficacy of Tongxinluo capsule versus placebo or no specific therapy based on usual care among patients with hypertensive nephropathy were included. Study selection and data extraction were independently conducted by two reviewers. The primary outcome was 24-hour urine protein, and secondary outcomes include the level of urinary β2-microglobulin, creatinine clearance rate, serum creatinine, systolic blood pressure, and diastolic blood pressure. In terms of safety, the incidence of adverse events was the main indicator. A fixed-effects model or random-effects model was used when applicable. A 2-tailed p&lt;0.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>Eight RCTs (742 participants) were included in our study. The quantitative synthesis showed that Tongxinluo capsule could significantly reduce 24-hour proteinuria (MD, -0.11; 95 % CI, -0.20 to -0.02) and urinary β2-microglobulin (MD, -244.26; 95 % CI, -463.50 to -25.01), and slightly increase creatinine clearance rate (MD, 2.28; 95 % CI, 0.42 to 4.14). No significant differences were observed in decreasing serum creatinine (MD, -8.82; 95 % CI, -18.00 to 0.36), or antihypertensive effect (systolic blood pressure [MD, -2.18; 95 % CI, -5.98 to 1.63]; diastolic blood pressure [MD, -2.55; 95 % CI -6.03 to 0.92]). There are no obvious anomalies in terms of adverse events.</div></div><div><h3>Conclusion</h3><div>This is currently the first systematic review to provide up-to-date evidence regarding the Tongxinluo capsule treatment profile in HN. Based on the available RCTs, Tongxinluo capsule showed promising renal protective benefits in reducing proteinuria levels, and could be a therapeutic option for HN. High-quality studies are needed to further verify our findings.</div></div><div><h3>Protocol registration</h3><div>PROSPERO (CRD42023484654).</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102521"},"PeriodicalIF":1.9,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of yoga and naturopathy in the management of melasma: A case report","authors":"Sunil Singh Yadav ,&nbsp;Rita Thapa ,&nbsp;Sangeeth Somanadhapai ,&nbsp;Deepeshwar Singh","doi":"10.1016/j.eujim.2025.102522","DOIUrl":"10.1016/j.eujim.2025.102522","url":null,"abstract":"<div><h3>Introduction</h3><div>Melasma is a common dermatological condition characterized by hyperpigmentation patches, often caused by hormonal imbalance, oxidative stress, and sun exposure. Conventional interventions usually have limited efficacy and may cause side effects. This case report explores the potential of traditional therapies in managing melasma, specifically yoga and naturopathy, which can enhance natural healing.</div></div><div><h3>Case Presentation</h3><div>A 27-year-old female diagnosed with persistent melasma visited a yoga and naturopathy center for the interventions. The patient was treated with a structured intervention protocol, including yogic-based breathing, dietary changes, and mud pack. The effect of this intervention was evaluated using Melasma Area Severity Index (MASI) and Melasma Quality of Life Scale (MELASQOL). After 60 days of intervention, MASI score improved by 85.12 %, and MELASQOL score improved by 75 %, indicating significant improvement in the clinical and quality of life questionnaires.</div></div><div><h3>Conclusion</h3><div>This case highlights the potential effectiveness of yoga and naturopathy in managing melasma. The positive outcome supports the role of traditional therapies in clinical practice; however, further research with larger sample sizes is required to confirm these findings.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"79 ","pages":"Article 102522"},"PeriodicalIF":1.7,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144763606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the utilization of traditional Korean medicine and continuity of care among individuals with disabilities in Korea: A cross-sectional analysis using national health insurance data","authors":"Ji-eun Yu ,&nbsp;Hyunmin Kim ,&nbsp;Chihyoung Son ,&nbsp;Eunji Ahn ,&nbsp;Dongsu Kim","doi":"10.1016/j.eujim.2025.102520","DOIUrl":"10.1016/j.eujim.2025.102520","url":null,"abstract":"<div><h3>Introduction</h3><div>In South Korea, under a dual healthcare system, both Western and traditional Korean medicine (TKM) play a role in managing the health of individuals with disabilities. This study aimed to identify various factors influencing TKM utilization by individuals with disabilities and the continuity of TKM care.</div></div><div><h3>Methods</h3><div>Data from the “Sample Cohort Database” of the National Health Insurance Service were used, focusing on 55,876 individuals registered as persons with disabilities. Multinomial logistic regression analysis was conducted to identify the factors associated with TKM utilization and the level of continuity of outpatient care in TKM, as measured by TKM Continuity of Care Index (TKM-COCI), among individuals with disabilities.</div></div><div><h3>Results</h3><div>This study included 53,444 registered individuals with disabilities. The entire cohort was analyzed for factors influencing TKM utilization, while a subset of 16,330 individuals with prior TKM experience was examined for factors affecting continuity of TKM. Analysis of TKM utilization patterns by disability type revealed that, for all disability types, individuals with musculoskeletal disorders had the highest proportion of TKM utilization, with a higher frequency of utilization observed for mild conditions than for severe conditions. Variables affecting both TKM utilization and TKM-COCI for individuals with disabilities included sex, long-term care insurance for the elderly, household income, severity and the Charlson Comorbidity Index. TKM utilization was lower among men, individuals with long-term care insurance, medical aid recipients, those without comorbidities, and individuals with severe disabilities; however, the probability of having a high TKM-COCI was higher in these cases.</div></div><div><h3>Conclusions</h3><div>It was found that the trends in TKM utilization and TKM-COCI showed opposing patterns according to the severity of disability and CCI. This suggests that the primary purpose of TKM utilization among individuals with disabilities is to prevent or manage the exacerbation of symptoms. Further investigation is needed to clarify this relationship.</div></div><div><h3>Funding</h3><div>No funding was received for this study.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102520"},"PeriodicalIF":1.9,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144670878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is traditional Chinese medicine syndrome differentiation important in primary insomnia? An exploratory review with matching recombination indirect comparisons and network meta-analysis","authors":"Guo-Dong Li ,&nbsp;Xin-Yu Hu ,&nbsp;Yi Yuan ,&nbsp;Xi-Jing Meng ,&nbsp;Le-Yan Hu ,&nbsp;Yu-Ting Huang ,&nbsp;Hui-Juan Cao","doi":"10.1016/j.eujim.2025.102515","DOIUrl":"10.1016/j.eujim.2025.102515","url":null,"abstract":"<div><h3>Introduction</h3><div>Syndrome differentiation is the primary method of Traditional Chinese Medicine (TCM) diagnosis and treatment of diseases and has become the key to the clinical development of acupuncture. However, there is a lack of supporting clinical evidence to determine the impact of syndrome differentiation on the efficacy of acupuncture treatment. Therefore, we aimed to evaluate the importance of point selection based on syndrome differentiation by re-analyzing the trials' results in treating primary insomnia with acupuncture.</div></div><div><h3>Methods</h3><div>We systematically searched 9 databases for eligible trials. Two authors extracted data independently from citations, interventions, and outcomes. Since the \"treatment acupuncture\" and \"control acupuncture\" data compared in this study were from different trials, we matched the data in a 1:1 ratio and minimized heterogeneity between the paired groups. Matching factors included age, sex ratio, and the baseline Pittsburgh Sleep Quality Index (PSQI) score. Meta-analyses were performed using Revman 5.4 software. STATA 15.0 was used for the network meta-analysis. Effect estimation presented continuous data with a standard mean difference (SMD) with a 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>We included a total of 172 trials. After matching, 19 recombinational pairs of studies were established. Meta-analysis of the 19 pairs showed that PSQI scores in the syndrome differentiation group were lower than the non-syndrome differentiation group (SMD: -0.87, 95 %CI -1.46 to -0.28, <em>P</em> = 0.004). Network meta-analysis of all included trials showed no statistical difference in acupoints selection between syndrome and non-syndrome differentiation (SMD: -0.40, 95 % CI -2.63 to 1.84). However, acupoint selection based on syndrome differentiation (43.9 %) ranks higher than acupoint selection based on non-syndrome differentiation (38.0 %) according to SUCRA curves.</div></div><div><h3>Conclusions</h3><div>Current evidence does not conclusively support the superiority of syndrome differentiation-based acupuncture over non-syndrome differentiation for primary insomnia. While statistically significant large effect size was observed in matched studies, the clinical relevance of this difference remains uncertain due to methodological limitations, heterogeneity, and inconsistent findings across analytical approaches. Future trials with direct comparisons and standardized outcome measures are needed to clarify the clinical utility of syndrome differentiation in acupuncture therapy.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102515"},"PeriodicalIF":1.9,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144572858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes of parents and primary care practitioners towards natural medicinal products (NMPs) for acute, uncomplicated upper respiratory tract infections and an NMP App: results from an online survey","authors":"E. Belt-van Zoen ,&nbsp;L. Veldman ,&nbsp;N. van Steenbergen ,&nbsp;M. Nieuwdorp ,&nbsp;E. Baars","doi":"10.1016/j.eujim.2025.102514","DOIUrl":"10.1016/j.eujim.2025.102514","url":null,"abstract":"<div><h3>Introduction</h3><div>Resistance to antibiotics is an increasing worldwide problem. Hence, identifying and implementing the use of alternatives to antibiotics is crucial. A prototype app providing evidence-based advice on the use of safe and effective natural medicinal products (NMPs) for acute, uncomplicated upper respiratory tract infections (URTIs) is being developed. This study investigates the acceptability of NMPs (for URTIs) and the idea of an NMP app among intended end-users.</div></div><div><h3>Methods</h3><div>An online survey was completed by parents (<em>n</em> = 103), general practitioners (GP; <em>n</em> = 110), nurse practitioners (<em>n</em> = 65), physician assistants (<em>n</em> = 65), and pharmacists (<em>n</em> = 71) working in Dutch primary care.</div></div><div><h3>Results</h3><div>The majority of parents (66–79 %) and professionals (40–98 %) reported past use, current recommendation, or future willingness to use NMPs for URTIs. The majority of respondents (73–82 %) indicated they would use or recommend an NMP app, with main reasons being convenience, practicality, and time-saving. Most important prerequisites for use were safety and effectiveness of the included NMPs. Pharmacists reported they would use an NMP app primarily for professional development and shared decision-making (both 53 %), whereas 72 % of parents and up to 57 % of other professionals would use it mainly to support self-management. Up to 61 % of respondents expected a reduction in antibiotic use, and up to 70 % anticipated fewer primary care visits for URTIs with the introduction of an NMP App.</div></div><div><h3>Conclusions</h3><div>This study indicates broad acceptance of NMPs for URTIs across intended end-user groups. An NMP app seems to be a well-supported tool for reducing antibiotic use and primary care visits for children with URTIs in Dutch primary care. However, a website or web-based tool may be more fitting than a standalone mobile application. Furthermore, to prevent the exacerbation of health inequalities, it is important to also develop tools that are accessible to parents with low (health) literacy and a lower socio-economic position. GP assistants and pharmacy assistants appear key end-users for further research and implementation.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102514"},"PeriodicalIF":1.9,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of propolis research: A bibliometric analysis","authors":"Tuğba Nigar Bozkuş","doi":"10.1016/j.eujim.2025.102518","DOIUrl":"10.1016/j.eujim.2025.102518","url":null,"abstract":"<div><h3>Introduction</h3><div>Propolis is garnering increasing scientific and commercial interest due to its potential health benefits. Despite a surge in publications, a comprehensive overview of the propolis research landscape using bibliometric methods has been absent. This study aims to fill this gap by providing the first dedicated bibliometric analysis of global propolis research trends over the past two decades.</div></div><div><h3>Methods</h3><div>Data on propolis-related publications from 2004 to 2023 were retrieved from the Web of Science database. The R Bibliometrix package was employed to analyze publication trends, citation patterns, leading authors, institutions, countries, keyword co-occurrence, research themes, and collaboration networks.</div></div><div><h3>Results</h3><div>The analysis confirmed a substantial and consistent growth in propolis research. While publication volume is geographically concentrated (led by Brazil, China, Turkey), citation impact analysis revealed different patterns, with some countries (USA, Japan, Portugal, Bulgaria) demonstrating higher average citations per article, suggesting potential leadership in research quality or visibility. Thematic evolution mapping showed a clear trajectory from foundational studies focused on chemical composition and broad in vitro antioxidant/antimicrobial activity towards more sophisticated investigations into specific mechanisms (apoptosis, oxidative stress pathways), distinct propolis types (Brazilian green, stingless bee), and advanced applications (nanoparticles, nanofibers). Analysis identified central ‘’motor themes’’ (like chemical composition) requiring further development despite high interest, alongside highly developed ‘’niche themes’’ (like oxidative stress). Collaboration networks highlighted strong regional clusters but also opportunities for enhancing global integration, particularly bridging high-volume research hubs with high-impact centers.</div></div><div><h3>Conclusion</h3><div>This bibliometric analysis reveals propolis research as a dynamic, rapidly maturing, and increasingly interdisciplinary field. The divergence between publication quantity and citation impact, the clear evolution of research themes towards mechanistic depth, and the identification of specific developmental needs within the thematic structure offer critical strategic insights. The findings underscore a significant gap between the extensive preclinical investigation of biological activities of propolis and its translation into validated clinical applications. The findings advocate focused efforts on standardization, targeted international collaborations to leverage complementary strengths, and prioritizing clinical trials to substantiate the therapeutic potential suggested by the vast body of existing literature. This analysis provides an evidence-based roadmap to guide future research investments and collaborations effectively.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102518"},"PeriodicalIF":1.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and acceptability of a yoga-based mind body intervention for women with a history of hypertensive disorder in pregnancy","authors":"Caroline A Smith ,&nbsp;Kylie Barr ,&nbsp;Angela Makris ,&nbsp;Amanda Henry ,&nbsp;Hannah Dahlen ,&nbsp;Annemarie Hennessy ,&nbsp;Alison Canty ,&nbsp;Wendy Pickup","doi":"10.1016/j.eujim.2025.102499","DOIUrl":"10.1016/j.eujim.2025.102499","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypertensive disorders of pregnancy affect 5 to 10% of women and are a significant cause of perinatal morbidity and mortality. This group of women have been shown to have an elevated risk of cardiovascular disease (CVD) and premature mortality. There are currently no interventions specifically targeting this at-risk group of women to reduce relevant risk factors and improve outcomes. In other populations of individuals at high CVD risk, studies suggest yoga may be effective in reducing CVD risk. This study examined the feasibility of yoga in contributing to the management of blood pressure postpartum.</div></div><div><h3>Methods</h3><div>A feasibility study was conducted. The primary objective was to examine recruitment, adherence, satisfaction, and safety of the yoga intervention. Secondary objectives included change in blood pressure, serological measures, quality of life and anxiety. Women were eligible from five to seven months postpartum. An online yoga intervention was delivered over eight weeks.</div></div><div><h3>Results</h3><div>Ten women (16% of those eligible) were recruited. All women completed the intervention. Compliance with the clinical outcome assessments ranged between 70 and 90%. There was high fidelity with intervention engagement. There were no significant changes over time in any clinical outcome, although a trend to overall improved quality of life (p=0.06) was seen. There were no adverse reactions reported.</div></div><div><h3>Conclusion</h3><div>Although uptake was low, women engaged well with postpartum yoga. Further research on yoga is needed to test effectiveness for CVD risk reduction for women with hypertension in the postpartum setting, involving an appropriately powered randomised controlled trial. The study was registered with the Australian and New Zealand Clinical Trial Registry (Registration number ACTRN: 12622000450718).</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102499"},"PeriodicalIF":1.9,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144653321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training needs for (UK) professional standards authority accredited register and regulated traditional, complementary and integrative medicine professions for supporting patients to make lifestyle and health behaviour changes: A rapid narrative review","authors":"Jonquil Pinto,&nbsp;Katie Read,&nbsp;Ella Tarabey,&nbsp;Felicity L. Bishop","doi":"10.1016/j.eujim.2025.102517","DOIUrl":"10.1016/j.eujim.2025.102517","url":null,"abstract":"<div><h3>Introduction</h3><div>Improving healthy lifestyles is a public health priority. Traditional, Complementary and Integrative medicine (TCIM) providers, and certain professions on the UK Professional Standards Authority (PSA) Accredited Registers (AR) may be well-placed to contribute - some TCIM professions already support patients to make behaviour changes. We aimed to map the landscape of training for PSA AR and regulated TCIM practitioners working with individuals to support lifestyle changes, including current provision, gaps and training needs.</div></div><div><h3>Methods</h3><div>We conducted a rapid narrative review of training within PSA AR and regulated TCIM professions. We searched research databases for articles exploring perceptions, experiences and responses to training (for supporting behaviour change) and searched websites of UK professional bodies for educational guidelines for pre-qualification education. We conducted systematic data searching and extraction, quality appraisal and produced a narrative synthesis of research and guidelines which identified patterns across professions.</div></div><div><h3>Results</h3><div>We identified 24 education guidelines (4 were unlocated). A total of 548 research studies were identified from database searches, and we identified 5 further studies. A total of 20 full-text articles were retrieved, 7 were excluded, leaving 13 in the review. While 22 of 24 guidelines mentioned lifestyle or health behaviour, only 4 (chiropractic, nutritional therapy, osteopathy and acupuncture) provided any detailed recommendations about how to support patients to make health behaviour changes (e.g. providing written information or recording/monitoring progress). Eight of the 13 research studies focussed on chiropractic; most studies focussed on physical activity, two on smoking cessation, and several looked at training in broad techniques including motivational interviewing. Practitioners in research studies were generally positive about training in lifestyle and health behaviour change and there was some evidence that such training enhances practitioner self-efficacy or skills.</div></div><div><h3>Conclusions</h3><div>Most evidence of engagement with supporting lifestyle/behaviour change is within four professions: chiropractic, osteopathy, nutritional therapy and acupuncture. To build on existing knowledge and practice, future training for chiropractors, osteopaths, nutritional therapists and acupuncturists could target the capabilities (e.g. knowledge, skills, decision-making), opportunities (e.g. resources) and motivations (e.g. social/professional role) of practitioners. Future research should also evaluate the impact of practitioner training on patients’ lifestyle and health behaviours.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"78 ","pages":"Article 102517"},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}