European Journal of Integrative Medicine最新文献

{"title":"Bloodletting therapy for primary headache: A systematic review and meta-analysis of randomized controlled trials","authors":"Shuai Dong,&nbsp;Yi-Ying Wang,&nbsp;Bo Li,&nbsp;Shi-Bing Liang,&nbsp;Hui-Juan Cao","doi":"10.1016/j.eujim.2023.102312","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102312","url":null,"abstract":"<div><h3>Introduction</h3><p>Headache is one of the most common symptoms worldwide. This systematic review aimed to assess the effectiveness and safety of bloodletting therapy (BLT) for primary headache.</p></div><div><h3>Methods</h3><p>Four English databases, four Chinese databases and five trials registries were searched from inception to 2^nd Sep 2022. Randomized controlled trials which compared BLT to no treatment or drugs for primary headache were included. BLT as adjunctive treatment of drugs or acupuncture was also included. Two authors extracted data and assessed the quality of trials through the Cochrane risk of bias tool 2.0 independently. Pain intensity was the primary outcome (e.g. Visual analogue scale, VAS). Meta-analysis (using RevMan 5.4.1) with random effect model was conducted when there was no serious statistical heterogeneity among trials (<em>I</em>²≤75 %). GRADE was used to assess the certainty of evidence.</p></div><div><h3>Results</h3><p>Seventeen trials involving 1123 participants were included. Types of BLT included pricking BLT, wet cupping and bloodletting puncture with plum-blossom needle. The most frequently used BLT acupoint was <em>Tai Yang</em>. Type of comparisons included BLT vs. drugs (<em>n</em> = 3), BLT plus drugs vs. drugs (<em>n</em> = 4) and BLT plus acupuncture vs. acupuncture (<em>n</em> = 10). All included trials were assessed as \"high risk of bias\". Results showed that BLT plus rizatriptan benzoate tablets was superior to drug alone in reducing VAS (Mean Difference (MD)=-2.07 cm, 95 % Confidence Interval (CI) -2.65 cm to -1.50 cm, <em>P</em>&lt;0.00001) and increasing the number of patients with more than half pain relief (by 39 %). BLT plus acupuncture was superior to acupuncture alone (MD=-0.80 cm, 95 % CI -1.20 cm to -0.41 cm, <em>P</em>&lt;0.00001) for pain relief. However, no difference was found between BLT and drugs on decreasing VAS. The certainty of the overall evidence is very low mainly due to the poor methodological quality and high heterogeneity among trials.</p></div><div><h3>Conclusion</h3><p>Very low certainty evidence suggests that BLT combined with acupuncture or drugs may be more effective in relieving pain of primary headache and other concomitant symptoms. Current evidence does not support confirmatory conclusions about the safety of BLT.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92045550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the quality of complementary, alternative, and integrative medicine website information for cancer: A cross-sectional survey and analysis","authors":"Jeremy Y. Ng,&nbsp;Maheen Raja,&nbsp;Umair Tahir,&nbsp;Harmy Thakar,&nbsp;Sabrina L. Balkaran","doi":"10.1016/j.eujim.2023.102309","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102309","url":null,"abstract":"<div><h3>Introduction</h3><p>Patients with cancer frequently utilize complementary, alternative, and integrative medicine (CAIM); prior to this, many seek information about these therapies online. Little is known about the quality of this web-based consumer health information. Our study aimed to address this paucity of research by evaluating the quality of CAIM consumer health information on websites discussing the treatment and/or management of cancer.</p></div><div><h3>Methods</h3><p>Six search terms were entered into Google across four English-speaking countries (Canada, United States, United Kingdom and Australia) on January 4, 2023. The first 20 results of each search were assessed and included if they contained CAIM consumer health information for the treatment and/or management of cancer. Eligible websites were assessed using the 16-item DISCERN instrument, designed to evaluate information quality.</p></div><div><h3>Results</h3><p>Of 480 identified websites, 393 were duplicates, and 48 fit the eligibility criteria and were assessed using the DISCERN instrument. Mean summed DISCERN scores across all websites was 48.28 (SD = 14.26), and mean scores of the overall quality of each website was 3.11 (SD = 0.66). Several website quality issues were identified, including a lack of transparency surrounding sources of information, areas of uncertainty regarding treatment, consequences of foregoing treatment, and treatment impacts on quality of life.</p></div><div><h3>Conclusion</h3><p>Healthcare providers should be aware that patients may use these websites for CAIM information. To facilitate informed decision-making, healthcare providers are encouraged to ask about patients’ usage and interest in CAIM and direct them to credible and trustworthy resources.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71725881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeopathy as patient empowerment and an active path toward supportive care for non-metastatic breast cancer: A qualitative study (TOUCAN)","authors":"Clair-Antoine Veyrier ,&nbsp;Guillaume Roucoux ,&nbsp;Laurence Baumann-Coblentz ,&nbsp;Jacques Massol ,&nbsp;Jean-Claude Karp ,&nbsp;Jean-Philippe Wagner ,&nbsp;Olivier Chassany ,&nbsp;Martin Duracinsky","doi":"10.1016/j.eujim.2023.102308","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102308","url":null,"abstract":"<div><h3>Introduction</h3><p>Breast cancer is the leading cause of death among French women, although the survival rate is increasing thanks to therapy and supportive care. Homeopathy is one of most widely used non-conventional supportive approaches in this context. This article aims to describe the ways women with non-metastatic breast cancer integrate homeopathy as supportive care into their conventional therapy regimen.</p></div><div><h3>Methods</h3><p>Qualitative semi-structured interviews and focus groups were conducted using interview guides. They were audio-recorded and first, partially transcribed to elicit emerging themes to revise the interview guide, and later word-for-word for in-depth analysis using Grounded Theory. Sampling, interviewing, transcription and coding occurred iteratively. The study has been reported according to COREQ guidelines.</p></div><div><h3>Results</h3><p>Fifty people participated: 28 patients, 13 oncologists, 6 homeopaths, 2 gynecologists and 1 nurse. Homeopathy was rarely present in the conventional patient care pathway. Turning to homeopathy was often the patient's initiative. Homeopathy was included to prevent or deal with adverse events from cancer treatments, while attempting to maximize clinical outcomes. Homeopathy was often used early in the care path if the patient had already consulted a homeopath. For others, the fear of chemotherapy triggered an active search for solutions. Homeopathic use was a form of empowerment and engagement, not only limited to patients who habitually used homeopathy. Most patients were treated by a general practitioner specialized in homeopathy, which was acknowledged by their oncologist.</p></div><div><h3>Conclusion</h3><p>Homeopathy acted as a gateway toward supportive care in tandem with conventional treatment.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71725879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of ear acupressure on sexual functioning among lactating women: A randomized sham controlled trial","authors":"Zainab Alimoardi ,&nbsp;Sanaz Barghamadi ,&nbsp;Terry Oleson ,&nbsp;Mohammad Hossein Ayati ,&nbsp;Mark D. Griffiths ,&nbsp;Nasim Bahrami","doi":"10.1016/j.eujim.2023.102285","DOIUrl":"10.1016/j.eujim.2023.102285","url":null,"abstract":"<div><h3>Introduction</h3><p>Women often experience more problems in sexual functioning after childbirth. Due to the high prevalence of sexual problems during the lactation period, the World Health Organization suggested measures are needed to improve women's sexual functioning during breastfeeding. The present study investigated the effect of auricular acupressure on sexual functioning among lactating women.</p></div><div><h3>Methods</h3><p>A randomized, sham-controlled trial was conducted between October 2019 to March 2020 in urban comprehensive health centers of Qazvin, Iran. Seventy-six women who had been lactating between six months and one year postpartum were randomly assigned to auricular acupressure group (<em>n</em> = 38) or sham control group (<em>n</em> = 38) using a balanced block randomization method. The intervention group received ear acupressure in 10 sessions (at four-day intervals) and control group also received the sham intervention at the same intervals. Sexual functioning was the primary outcome of the study (assessed using the Female Sexual Function Index) before and at three time points post-intervention (immediately after, one month after, and two months after). The secondary outcome was sexual quality of life assessed using Sexual Quality of Life-Female Version.</p></div><div><h3>Results</h3><p>Auricular acupressure had a large effect size on female sexual functioning at all three post-intervention time points: immediately after the intervention (adjusted mean difference [95% CI]: 8.37 [6.27; 10.46] with Cohen's <em>d</em> [95% CI]: 1.81[1.28; 2.34]), one month after the intervention (adjusted mean difference [95% CI]: 8.44 [6.41; 10.48] with Cohen's <em>d</em> [95% CI]: 2.01 [1.46; 2.56]), and two months after the intervention (adjusted mean difference [95% CI]: 7.43 [5.12; 9.71] with Cohen's <em>d</em> [95% CI]: 1.57 [1.06; 2.08]). The intervention significantly increased participants’ sexual quality of life on the Sexual Quality of Life-Female scale by 13.73 points in the intervention group compared to the control group (<em>p</em>&lt;0.001). The effect size of intervention for female sexual quality was large (adjusted Cohen's <em>d</em> [95% CI]: 1.09 [0.58; 1.59]). Weekly frequency of sexual intercourse in the intervention group significantly increased compared to sham control group (<em>p</em>&lt;0.001). These changes were clinically significant for sexual functioning and sexual quality of life.</p></div><div><h3>Conclusion</h3><p>Auricular acupressure appears to be an effective intervention for improving sexual functioning and sexual quality life of lactating women.</p></div><div><h3>Clinical trial registration</h3><p>Registered with the code of IRCT20190626044028N1 in the Clinical Trial Registration Center of Iran.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49370421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical effects of Baduanjin qigong exercise on cancer-related fatigue: A systematic review and meta-analysis","authors":"QianQian Liu,&nbsp;LiuYan Zhan,&nbsp;Xue Yan,&nbsp;Yao Li,&nbsp;SiQi Wei","doi":"10.1016/j.eujim.2023.102283","DOIUrl":"10.1016/j.eujim.2023.102283","url":null,"abstract":"<div><h3>Introduction</h3><p>A number of randomized controlled trials have investigated the benefits of Baduanjin qigong on cancer-related fatigue (CRF) in cancer survivors. However, the results of these studies were inconclusive and contradictory, due to the limitations of small sample sizes and different measurement scores. We conducted this systematic review and meta-analysis of the evidence available to critically evaluate the efficacy and safety of Baduanjin qigong in improving CRF in cancer patients.</p></div><div><h3>Methods</h3><p>Eight databases (The Cochrane Library, PubMed, EMBASE, Web of Science, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Scientific Journal Database (VIP), and WanFang Database)) were systematically reviewed from inception to September 2022 for randomized controlled trials (RCTs). Two reviewers critically and independently assessed the risk of bias using the Cochrane Collaboration criteria and independently extracted relevant data using the designed tables. All statistical analyses were performed using Review Manager 5.3.</p></div><div><h3>Results</h3><p>Thirteen eligible studies were included in this systematic review, including 1010 patients. Baduanjin qigong as an add-on therapy significantly improved fatigue symptom scores (Standardized mean difference -1.43, 95% CI -2.01 to -0.84, <em>P</em>&lt; 0.0001, RCTs= 9, <em>n</em> = 640). We found that different intervention frequencies, intervention durations, and intervention cycles of Baduanjin qigong exercise were effective in relieving fatigue, and the differences in effectiveness were similar for different types of cancer patients. Two RCTs reported no adverse events associated with Baduanjin qigong.</p></div><div><h3>Conclusion</h3><p>Baduanjin qigong may reduce CRF in cancer patients and may be used as a traditional and complementary medicine option for the clinical management of CRF. However, large and well-designed randomized controlled trials are still needed to confirm these findings.</p></div><div><h3>Registration</h3><p>PROSPERO CRD42022369410.</p></div><div><h3>Funding</h3><p>Lanzhou University, China (grant number 561,120,201) and Natural Science Youth Fund of Gansu Province (grant number 23JRRA1110).</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45175459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and multiple visualization methods for the therapeutic effects prediction model of five-flavor Sophora Flavescens enteric-coated capsules in the treatment of active ulcerative colitis: A study on model development and result visualization","authors":"Zhi-Jun Bu ,&nbsp;Zhi-Rui Huang ,&nbsp;Yun-Ru Chen ,&nbsp;You-Zhu Su ,&nbsp;Yuan-Yuan Jin ,&nbsp;Yu-Huan Zhang ,&nbsp;Qiu-Ju Wu ,&nbsp;Xue-Hui Wang ,&nbsp;Yu Wang ,&nbsp;Jian-Ping Liu ,&nbsp;Zhao-Lan Liu","doi":"10.1016/j.eujim.2023.102297","DOIUrl":"10.1016/j.eujim.2023.102297","url":null,"abstract":"<div><h3>Introduction</h3><p>The aim of this study was to develop a Therapeutic Effects Prediction Model (TEPM) for the treatment of active ulcerative colitis (UC) using Five-flavor Sophora Flavescens Enteric-coated Capsules (FSEC). This study also aimed to systematically review various visualization methods for the TEPM results and present the model results of FSEC as an example.</p></div><div><h3>Methods</h3><p>274 patients were randomly assigned to the training and testing datasets in a 7:3 ratio. We employed Least Absolute Shrinkage and Selection Operator (LASSO) regression to select predictive factors and constructed TEPM using logistic regression to assess the probability of disease remission. We assessed model performance by the area under the curve (AUC) and calibration curve. We utilized interactive nomograms, online calculators, scoring systems, graphical scoring tables, as well as the SHapley Additive exPlanations (SHAP) and Local Interpretable Model-agnostic Explanations (LIME) methods to present the model results.</p></div><div><h3>Results</h3><p>LASSO regression selected several predictors, including erythrocyte sedimentation rate, age, disease type, microscopic bleeding, pus, bridge, disease location, and pain. The AUC of the testing datasets was 0.699, and the calibration curve showed poor performance. The interactive nomogram, online calculator, and the SHAP method were suitable for datasets with predominantly continuous predictors, while scoring systems, graphical scoring tables, and the LIME method might be more appropriate for datasets with fewer continuous predictors. Physicians, researchers, and policymakers could benefit from detailed visualizations using interactive nomogram, the SHAP method, and the LIME method. Scoring systems, graphical scoring tables, and online calculator were available to the general public and non-experts. Scoring systems, graphical scoring tables, and online calculator could provide an overview of the model prediction results, while interactive nomogram, the SHAP method, and the LIME method were recommended for illustrating the complexity and rationality of the model prediction results.</p></div><div><h3>Conclusion</h3><p>Our study demonstrated that TEPM could predict the potential of FSEC to induce disease remission in patients with active UC. However, the poor calibration curve might be due to the limited sample size. Larger-scale multicenter studies will be needed in the future. Selecting an appropriate visualization method for TEPM should be based on the datasets, audience, and research objectives.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47765210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese herbal medicine for primary dysmenorrhea: A systematic review and network meta-analysis of 54 randomized controlled trials","authors":"Xinbin Wang ,&nbsp;Zhongwen Zhang ,&nbsp;Haorui Wang ,&nbsp;Ruilin Ma ,&nbsp;Lili Wang ,&nbsp;Xianhui Zhang ,&nbsp;Yi Zhang ,&nbsp;Rong Wang","doi":"10.1016/j.eujim.2023.102293","DOIUrl":"10.1016/j.eujim.2023.102293","url":null,"abstract":"<div><h3>Introduction</h3><p>Primary dysmenorrhea (PD) is a common gynecological complaint among adolescents and young women. Chinese herbal medicines (CHMs) have been widely used for PD treatment in China. However, the relative advantages of different CHM regimens remain uncertain. This systematic review aimed to compare the efficacy and safety of different CHMs for the treatment of PD using network meta-analysis.</p></div><div><h3>Methods</h3><p>We searched PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Chinese BioMedical Literature Database (CBM) from their inception to December 17, 2022. Randomized controlled trials (RCTs) comparing CHM or Chinese patent drugs with Prostaglandin Synthetase Inhibitors (PGSIs) were included. Risk of bias was assessed using the Cochrane risk of bias tool. A frequentist framework network meta-analysis was performed using R (4.2.2).</p></div><div><h3>Results</h3><p>A total of 54 RCTs with 5,345 PD patients were included. Compared with PGSIs, Danggui Sini decoction (mean difference [MD] = -5.92, 95% confidence interval [CI] -8.64 to -3.20) and Xiangfu Siwu Decoction (MD = -4.63, 95%CI -8.37 to -0.89) reduced pain significantly.; Danggui Sini decoction (risk ratio[RR] = 1.31, 95%CI 1.12 to 1.53), Danggui shaoyao san (RR = 1.23, 95%CI 1.05 to 1.44), Siwu decoction (RR = 1.32, 95%CI 1.17 to 1.47), Taohong Siwu Decoction (RR = 1.35, 95%CI 1.14 to 1.61), and Wenjing decoction (RR = 1.33, 95%CI 1.19 to 1.52) showed significantly higher overall response rates, and Wenjing decoction could significantly reduce TCM syndrome scores (MD = -4.14, 95%CI -6.84 to -1.44), compared with PGSIs. No serious adverse events were observed. Siwu decoction and Wenjing decoction ranked as the top treatment options in terms of all outcomes of interest (P-score ranking).</p></div><div><h3>Conclusions</h3><p>CHMs were associated with improved overall response rate, pain reduction, and alleviation of symptoms compared to conventional treatments for patients with PD, and no serious adverse events were observed. However, the confidence in the conclusions is limited because of the lack of high-quality trials.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45583358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moxibustion for chemotherapy-induced myelosuppression: A systematic review and meta-analysis","authors":"Xiao-Qing Wang ,&nbsp;Yue Qiao ,&nbsp;Yuan-Yuan Zhang ,&nbsp;Li-Hua Yang ,&nbsp;Pei-Bei Duan","doi":"10.1016/j.eujim.2023.102304","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102304","url":null,"abstract":"<div><h3>Introduction</h3><p>Myelosuppression is a common treatment-related complication in cancer patients. Moxibustion has been proposed as a potentially effective intervention to alleviate the side effects of chemotherapy-induced myelosuppression. This review aimed to investigate the effectiveness and safety of moxibustion in treating chemotherapy-induced myelosuppression, as well as the most promising modalities and patterns of moxibustion application.</p></div><div><h3>Methods</h3><p>We included randomised controlled trials (RCTs) focusing on the effectiveness of moxibustion on chemotherapy-induced myelosuppression, including the total effective rate, leukocyte count, hemoglobin level, platelet count, neutrophil count, and quality of life as outcomes. Six English and four Chinese databases were searched. Two researchers independently screened the articles, extracted data, and evaluated the quality of the included studies. The quality was assessed using the revised Cochrane Risk-of-Bias tool (RoB 2.0). Meta-regression and subgroup analyses were used to find the most effective modalities and treatment patterns. In addition, we utilised the Grading of Recommendations Assessment, Development, and Evaluation system to establish a persuasive conclusion. Data were meta-analysed using Stata (version 14.0).</p></div><div><h3>Results</h3><p>Twenty-one studies were included in this systematic review, including 1887 patients. The overall quality of all included studies was moderate. Meta-analysis of 9 RCTs indicated that moxibustion provided a greater therapeutic benefit in the treatment of chemotherapy-induced myelosuppression (RR=1.22, 95%CI=1.15, 1.29, P&lt;0.001). Moreover, the results of 15 RCTs showed a significant increase in leukocyte count (WMD=0.62, 95% CI=0.08, 1.16, P=0.025); 3 RCTs showed elevated hemoglobin level (WMD=11.72, 95%CI=5.67, 17.76, P&lt;0.001), and 3 RCTs showed increased platelet count (WMD=16.24, 95% CI=10.37, 22.11, P&lt;0.001). Furthermore, the results of 5 RCTs showed a significant favourable effect on the quality of life (WMD=5.54, 95%CI=3.09, 7.98, P&lt;0.001). We also assessed the certainty of the body of evidence and the results showed that the total effective rate was assessed as moderate quality, while others were rated as very low. There was no publication bias in this meta-analysis. In addition, five studies reported adverse effects, and none were serious.</p></div><div><h3>Conclusions</h3><p>Moxibustion may affect chemotherapy-induced myelosuppression. However, owing to the small number of included studies and their low methodological quality, more large-scale, multi-center, high-quality RCTs on moxibustion for chemotherapy-induced myelosuppression are needed.</p></div><div><h3>Registration</h3><p>CRD42022336319.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49861930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of the combination of Chinese herbal medicine and acupuncture for women with polycystic ovarian syndrome: A systematic review and meta-analysis of randomized controlled trials","authors":"Xing-yan Liang ,&nbsp;Chun-li Lu ,&nbsp;Yu Su ,&nbsp;Xin-yan Jin ,&nbsp;Mu-lian Wu ,&nbsp;Yao Lu ,&nbsp;Yu Zhou ,&nbsp;Zi-xun Zhuang ,&nbsp;Chun Luo ,&nbsp;Hong-xia Ma","doi":"10.1016/j.eujim.2023.102291","DOIUrl":"https://doi.org/10.1016/j.eujim.2023.102291","url":null,"abstract":"<div><h3>Introduction</h3><p>This systematic review<span> aimed to evaluate the effectiveness and safety of Chinese herbal medicine (CHM) plus acupuncture for women with polycystic ovarian syndrome (PCOS).</span></p></div><div><h3>Methods</h3><p>We searched for eligible randomized controlled trials (RCTs) in nine Chinese and English databases from their inception to May 7, 2023. The Cochrane “Risk of bias” tool and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methods were used to assess the methodological quality and the certainty of the evidence. Effectiveness is presented as the risk ratio (RR) or mean difference with 95% confidence interval (CI).</p></div><div><h3>Results</h3><p>A total of 52 studies were included in this systematic review (<em>n</em><span> = 4180 participants). The overall quality of the RCTs was reduced by unclear or high risk of bias. The certainty of the evidence ranged from very low certainty to moderate certainty. None of the included studies reported the live birth rate. Among women with PCOS seeking fertility treatment, both CHM and acupuncture had a beneficial effect on the clinical pregnancy rate (CHM plus acupuncture (Intervention A), 9 RCTs, </span><em>n</em><span> = 754 participants, RR 1.28, 95% CI 1.10, 1.49; moderate certainty evidence; CHM plus acupuncture plus CMT (Intervention B), 16 RCTs, </span><em>n</em><span> = 1269 participants, RR 1.71, 95% CI 1.50, 1.94; moderate certainty evidence) and ovulation rate (Intervention A, 5 RCTs, </span><em>n</em> = 395 participants, RR 1.31, 95% CI 1.15, 1.49; low certainty evidence; Intervention B, 7 RCTs, <em>n</em> = 729 participants, RR 1.31, 95% CI 1.16, 1.48; low certainty evidence) compared to the control group.</p></div><div><h3>Conclusions</h3><p>There is currently very low to moderate certainty evidence that CHM plus acupuncture can improve the fertility and clinical symptoms of PCOS patients. Further rigorous, double-blinded, placebo-controlled trials are needed to determine the effectiveness of complex interventions of CHM plus acupuncture for treating PCOS.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49861935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scoping review of clinical studies on Chinese herbal medicine against Helicobacter pylori and an exploration of its usage pattern","authors":"Yang Zhang ,&nbsp;Xiaoyang Hu ,&nbsp;Huafeng Zhang ,&nbsp;Yujia Pan ,&nbsp;Zongyu Zhang ,&nbsp;Tianjiao You ,&nbsp;Yaguang Han ,&nbsp;Jiali Wei ,&nbsp;Wenjuan Shen","doi":"10.1016/j.eujim.2023.102268","DOIUrl":"10.1016/j.eujim.2023.102268","url":null,"abstract":"<div><h3>Introduction</h3><p>Helicobacter pylori (H. pylori) is a highly infectious bacterium that can aggravate upper gastrointestinal diseases. With the increasingly serious problem of H. pylori drug resistance, it is important to identify new treatment methods. In recent years, there has been an increasing number of studies on the treatment of H. pylori infection and related diseases with Chinese herbal medicine (CHM). The effectiveness of CHM has also emerged. Therefore, the aim of this scoping review was to systematically identify and summarize the characteristics of randomized controlled trails (RCTs) evaluating CHM for treating H. pylori infection.</p></div><div><h3>Methods</h3><p>Three Chinese and two English language databases were comprehensively searched. Included studies were RCTs of H. pylori-positive patients evaluating oral CHM with or without Western Medicine (WM) compared to WM alone. A descriptive analysis of study characteristics and association rule mining in R Studio software were used to identify frequent herbal combinations. The Cochrane Collaboration Risk of Bias tool was used to assess study quality.</p></div><div><h3>Results</h3><p>Included were 165 RCTs, with 168 comparisons, involving 16,817 participants. All the RCTs were conducted in China and 68% were published after 2012. The quality of included studies was moderate. The RCTs evaluated 187 herbs that were used in various combinations in 91 types of CHM formulas. Most RCTs compared CHM plus WM to WM only (n = 103 comparisons). Only 68% of the RCTs evaluated a recommended WM triple or quadruple therapy. Results showed that Banxia Xiexin Decoction, Huangqi Jianzhong Decoction, Huanglian Wendan Decoction and Jinghua Weikang Capsule were commonly used. The association rules showed that golden thread (Coptis chinensis Franch.), debark peony root (Paeonia lactiflora Pall.), milkvetch root (Astragalus mongholicus Bunge), dandelion (Taraxacum mongolicum Hand.-Mazz.), dried tangerine peel (Citrus reticulata Blanco), tangshen (Codonopsis pilosula (Franch.) Nannf.), largehead atractylodes rhizome (Atractylodes macrocephala Koidz.), processing liquorice root (Glycyrrhiza glabra L.), pinellia tuber (Pinellia ternata (Thunb.) Makino) were commonly used clinically.</p></div><div><h3>Conclusion</h3><p>The findings from this review highlight the potential role of CHM formulas for treating H. Pylori and can be used to inform further clinical trials and systematic reviews.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43462174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}