European Journal of Integrative Medicine最新文献

{"title":"Effects of Zhangyanming tablet treating dry eye disease: A prospective, open-label, randomized controlled trial","authors":"Hong-bin Xie ,&nbsp;Yuan Zhang ,&nbsp;Jun-hong Guo ,&nbsp;Ming-min Yang ,&nbsp;Jia-jia Hu ,&nbsp;Jie-wen Zhou ,&nbsp;Da-hui Ma","doi":"10.1016/j.eujim.2025.102574","DOIUrl":"10.1016/j.eujim.2025.102574","url":null,"abstract":"<div><h3>Introduction</h3><div>Dry eye disease (DED) is a chronic ocular surface disease that seriously affects quality of life. Traditional Chinese medicine (TCM) has prominent advantages in the treatment of DED. This study investigated the efficacy and safety of Chinese medicine Zhangyanming tablets (ZYMT) combined with fluorometholone eye drops (FED) and human epidermal growth factor eye drops (HEGFED) in the treatment of DED.</div></div><div><h3>Methods</h3><div>This was a randomized controlled study. A total of 122 patients with DED were randomly divided into the intervention group (<em>n</em> = 61) and the control group (<em>n</em> = 61). The control group received FED and HEGFED treatment (one drop twice daily), while the intervention group was given ZYMT (0.84 g orally, three times daily) in addition to the control group’s treatment. Both groups underwent 8 weeks of treatment. The primary outcome was the efficacy rate. The secondary outcomes included the mean change from baseline in the OSDI score and its subscales, tear film breakup time (BUT) and Schirmer’s test.</div></div><div><h3>Results</h3><div>After 8 weeks of treatment, the efficacy rate was 75.9 % (44/58) in the intervention group versus 54.2 % (32/59) in the control group (absolute difference 21.6 %, 95 % CI, 4.3 %∼37.2 %; risk ratio 1.40). The mean change from baseline in the OSDI score in the intervention group were significantly greater than those in the control group in week 8 (absolute difference -6.25, 95 % CI, -9.08∼-3.42). The mean changes from baseline in BUT, Schirmer’s test were significantly greater in the intervention group than that of the control group in both week 4 (BUT: absolute difference 2.49 s, 95 % CI, 1.82∼3.15 s; Schirmer’s test: absolute difference 1.11 mm/5 min, 95 % CI, 0.28∼1.95 mm/5 min) and week 8 (BUT: absolute difference 2.93 s, 95 % CI, 2.37∼3.49 s; Schirmer’s test: absolute difference 4.36 mm/5 min, 95 % CI, 3.88∼4.84 mm/5 min). No significant difference was observed in the safety profiles in these two groups (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Compared to using FED and HEGFED alone, combined intervention of ZYMT can effectively ameliorate the eye symptoms of DED patients, and improve the efficacy rate.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102574"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of traditional east asian herbal medicine decoctions on low back pain: A systematic review and meta-analysis","authors":"Gyu Chan Shim ,&nbsp;Sook-Hyun Lee ,&nbsp;Yoon Jae Lee ,&nbsp;Su Won Lee ,&nbsp;In-Hyuk Ha","doi":"10.1016/j.eujim.2025.102555","DOIUrl":"10.1016/j.eujim.2025.102555","url":null,"abstract":"<div><h3>Introduction</h3><div>Low back pain (LBP) is a major cause of disability and economic burden. Herbal medicine (HM) decoctions, a core component of Traditional East Asian Medicine (TEAM), are gaining attention for their potential benefits. This systematic review evaluated HM decoctions for LBP.</div></div><div><h3>Methods</h3><div>The protocol was registered in PROSPERO (CRD42024599753). Eleven databases were searched for randomized controlled trials (RCTs) on HM decoctions for LBP published before July 2024. Primary outcomes were the clinical improvement rate (CIR) and visual analogue scale (VAS) for pain. Secondary outcomes included the Oswestry Disability Index and the Japanese Orthopedic Association scale. Quality assessments using the Cochrane Risk of Bias 2 tool and meta-analyses were conducted.</div></div><div><h3>Results</h3><div>Twenty-nine RCTs involving 2420 participants with LBP were included. HM decoction compared to Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) improved the CIR (risk ratio [RR] 1.16, 95 %CI: 1.05 to 1.29) and reduced VAS-pain (mean difference [MD] -0.87, 95 %CI: -1.59 to -0.14). When combined with TEAM, HM decoction improved the CIR (RR, 1.23, 95 %CI: 1.14 to 1.33) and VAS-pain (MD -1.24, 95 %CI: -1.80 to -0.67) compared to TEAM alone. The combination of HM decoction and TEAM improved the CIR (RR 1.25, 95 %CI: 1.01 to 1.55) and VAS-pain (MD -0.51, 95 %CI: -0.67 to -0.34) compared to NSAIDs alone, and a higher CIR (RR 1.30, 95 %CI: 1.12 to 1.52) than TEAM combined with NSAIDs. Combining HM decoction with NSAIDs improved the CIR (RR 1.48, 95 %CI: 1.19 to 1.85) compared to NSAIDs alone; however, there was no difference in VAS-pain (MD -1.09, 95 %CI: -2.35 to 0.17). HM decoction combined with non-pharmacological therapies (NPTs) improved the CIR (RR 1.18, 95 %CI: 1.05 to 1.32) and VAS-pain (MD -1.28, 95 %CI: -1.42 to -1.14). Finally, adding HM decoction to a regimen of NSAIDs and NPTs also improved the CIR (RR 1.24, 95 %CI: 1.09 to 1.42, but the reduction in VAS-pain was not statistically significant (MD -1.53, 95 %CI: -3.35 to -0.29).. In the seven RCTs that reported adverse events, these were absent or mild and comparable across intervention and control groups.</div></div><div><h3>Conclusion</h3><div>HM decoction demonstrated beneficial clinical effects for participants with LBP. Limitations included high risk of bias in many RCTs. Well-designed RCTs are warranted to validate effectiveness.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102555"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Qingwei Zhitong pellets combined with bismuth quadruple therapy for Helicobacter pylori eradication: A randomized controlled trial","authors":"Zhen Li ,&nbsp;Xiaolin Zhao ,&nbsp;Kun Huang ,&nbsp;Yong Cai ,&nbsp;Chanjuan Fan ,&nbsp;Dongling Xie ,&nbsp;Lili Zhai ,&nbsp;Sheng Li ,&nbsp;Xiaomei Zhang ,&nbsp;Haiou Ding ,&nbsp;Pan Wang ,&nbsp;Jianping Cheng","doi":"10.1016/j.eujim.2025.102557","DOIUrl":"10.1016/j.eujim.2025.102557","url":null,"abstract":"<div><h3>Introduction</h3><div>We previously reported that Qingwei Zhitong pellets (QZP)-containing quadruple therapy was safe and effective for <em>Helicobacter pylori</em> (<em>H. pylori</em>) eradication. However, it remains unclear whether QZP adjunctive to bismuth-based quadruple therapy (BQT) enhances <em>H. pylori</em> eradication rates and reduces adverse events. The aim of this study was to investigate the effect of adding QZP to BQT on the eradication rate of <em>H. pylori</em>.</div></div><div><h3>Methods</h3><div>In this single-center, randomized controlled trial, 336 patients were randomized 1:1:1 to receive 14-day therapy with either BQT (compound bismuth aluminate 1.3 g three times daily, rabeprazole 20 mg twice daily, amoxicillin 1 g twice daily, clarithromycin 500 mg twice daily), BQT plus QZP (3.2 g three times daily), or triple therapy (rabeprazole, amoxicillin, clarithromycin at aforementioned doses) plus QZP (3.2 g three times daily). The primary endpoint was the eradication rate of <em>H. pylori</em>. Secondary endpoints included symptom improvement, adverse effects, and treatment compliance.</div></div><div><h3>Results</h3><div>In intention-to-treat analysis, eradication rates were significantly higher with BQT-QZP (85.7 %) than with TT-QZP (73.2 %) or BQT (74.1 %) (RR 0.85, 95 % CI 0.76–0.96 and RR 0.86, 95 % CI 0.78–0.96, respectively). BQT-QZP showed superior symptom outcomes, with higher rates of complete resolution (13.4 % vs. 6.3 % and 4.5 %) and overall improvement (86.6 % vs. 63.4 % and 53.6 %). BQT-QZP also resulted in the highest total effective rate (71.4 % vs. 54.5 % and 60.7 %) and healing rate (19.6 %). The three groups demonstrated comparable rates of overall adverse events, and treatment compliance rates were high, with comparable levels between the groups.</div></div><div><h3>Conclusions</h3><div>A 14-day BQT combined with QZP quintuple therapy achieves an acceptable eradication rate as first-line anti-<em>H. pylori</em> therapy.</div></div><div><h3>Registration</h3><div>ChiCTR2300077090.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102557"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145270029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of Astragalus membranaceus-based traditional Chinese medicine in treating diabetic foot ulcers: A systematic review and meta-analysis of randomized controlled trials","authors":"Bingrui Zhang ,&nbsp;Kebin Wang ,&nbsp;Yuxiao Li ,&nbsp;Qinhua Fan ,&nbsp;Qingxiao Li ,&nbsp;Yingqiu Sun ,&nbsp;Yawei Du ,&nbsp;Wenquan Su ,&nbsp;Shengxian Wu","doi":"10.1016/j.eujim.2025.102561","DOIUrl":"10.1016/j.eujim.2025.102561","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Astragalus membranaceus</em> (AM) is a traditional Chinese medicine employed for supplementing qi and particularly used for ulcer treatment. This systematic review aimed to examine the effectiveness and safety of AM-based prescriptions (AMPs) for diabetic foot ulcer (DFU).</div></div><div><h3>Methods</h3><div>We searched eight databases to identify randomized controlled trials (RCTs) focusing on AMPs for DFU. The mean difference (MD) and relative risk (RR) with 95% confidence interval (CI) were calculated and used in the meta-analysis.</div></div><div><h3>Results</h3><div>We included 44 RCTs involving 3,238 participants. The AMPs included 24 oral AM formulas, 14 topical AM formulas, 4 topical AM alone, and 2 injections. Overall, study quality was low. Compared with Western medicine (WM), AMPs were associated with a higher healing rate (RR 1.64, 95% CI 1.4 to 1.9, 8 RCTs, n = 747), smaller ulcer size (MD –12.11 cm², 95% CI –19.23 to –4.99, 4 RCTs, n = 304) and shorter healing time (MD –7.82 days, 95% CI –10.59 to –5.05, 4 RCTs, n = 353). AMPs plus WM were more efficacious than WM in healing rate (RR 1.22, 95% CI 1.07 to 1.4, 20 RCTs, n = 1497), amputation rate (RR 0.42, 95% CI 0.27 to 0.66, 3 RCTs, n = 265), mortality (RR 0.29, 95% CI 0.12 to 0.71, 3 RCTs, n = 265), ulcer size (MD –1.78 cm², 95% CI –2.55 to –1.01, 10 RCTs, n = 761), healing time, ankle-brachial index (ABI), pain scores, clinical effective rate, and general symptoms. No severe adverse events were reported in the AMPs group.</div></div><div><h3>Conclusion</h3><div>AMPs may have potential effectiveness in ulcer healing, ABI increase, and pain alleviation. The exact efficacy of AMPs for DFU needs to be confirmed using high-quality double-blind RCTs.</div></div><div><h3>Registration</h3><div>Protocol of this review was registered via PROSPERO (CRD42024613403).</div></div><div><h3>Funding</h3><div><span>National Science and Technology Major Project of China</span> [grant number <span><span>2017ZX09304019</span></span>].</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102561"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the demands for home-based healthcare services using traditional Korean medicine in older adults and individuals with disabilities: A mixed methods study","authors":"Soo-Hyun Sung ,&nbsp;Kyeong-Han Kim ,&nbsp;Hyein Jeong ,&nbsp;Soobin Jang","doi":"10.1016/j.eujim.2025.102568","DOIUrl":"10.1016/j.eujim.2025.102568","url":null,"abstract":"<div><h3>Introduction</h3><div>Many older adults and individuals with disabilities experience significant barriers to accessing clinic-based health services, often resulting in unmanaged chronic conditions and diminished quality of life. Home-based healthcare is emerging as a viable solution, and interest in traditional Korean medicine is increasing due to its accessibility and perceived safety. This study aimed to identify the needs and expectations of older adults and individuals with disabilities for home-based healthcare using traditional Korean medicine.</div></div><div><h3>Methods</h3><div>Our study employed a mixed methods design that combined survey data and qualitative research. The online survey was conducted among two groups: 1) older adults aged 65 years and older and 2) individuals with disabilities aged 20 years and older. Semi-structured focus group interviews were conducted for the respondents who received home visits from traditional Korean medicine doctors</div></div><div><h3>Results</h3><div>Survey findings revealed that older adults showed a higher demand and willingness to participate in home-based healthcare services than individuals with disabilities. Respondents identified chronic conditions such as hypertension, diabetes, stroke, and dementia as key targets for home-based care. High-priority needs included physical and mental health support, health monitoring, and integration with conventional medical services. The most valued benefit of home-based care was improved accessibility for those with difficulty visiting hospitals. Focus group interview participants, particularly older adults, described feeling psychologically supported and satisfied through extended health counseling provided during house calls. Individuals with disabilities emphasized the need for transportation support for follow-up hospital visits.</div></div><div><h3>Conclusions</h3><div>Our findings provide foundational evidence for the development of integrated, home-based healthcare policies targeting older adults and people with disabilities. Expanding home-based traditional Korean medicine care may address health inequities and enhance well-being among populations with limited mobility.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102568"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of dietary chitosan on serum lipid levels: A systematic review and meta-analysis of randomised controlled trials","authors":"Yenn Ye Yap ,&nbsp;Zoriah Aziz","doi":"10.1016/j.eujim.2025.102578","DOIUrl":"10.1016/j.eujim.2025.102578","url":null,"abstract":"<div><h3>Introduction</h3><div>Hypercholesterolaemia is a key risk factor for cardiovascular diseases. Although chitosan is known for its weight loss properties, its effects on serum lipid levels remain unclear. This study aimed to evaluate the effects of dietary chitosan on serum lipid levels, including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and total cholesterol (TC).</div></div><div><h3>Methods</h3><div>A comprehensive search of electronic databases including Medline, Scopus, Cochrane Central Register of Controlled Trials, Web of Science, and CINAHL Complete was conducted. Randomised controlled trials (RCTs) were eligible if they assessed the effects of chitosan on LDL-C, HDL-C, TG, and TC in patients with hypercholesterolaemia or dyslipidaemia at baseline. We assessed the risk of bias of included studies, pooled the results using a random-effects model, and evaluated the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework.</div></div><div><h3>Results</h3><div>We included 16 RCTs involving a total of 1327 participants. The meta-analysis showed chitosan was associated with statistically significant reduction of LDL-C (WMD: -0.16 mmol/L, 95% CI: -0.23 to -0.10), TG (WMD: -0.04 mmol/L, 95% CI: -0.08 to -0.01), and TC (WMD: -0.25 mmol/L, 95% CI: -0.36 to -0.14), while the effect on HDL-C was not statistically significant (WMD: 0.01 mmol/L, 95% CI: -0.02 to 0.04). Adverse events, mainly mild gastrointestinal (GI) symptoms, were reported in 11 of 16 studies, with constipation being the most common. Subgroup analyses indicated variations in treatment effects based on chitosan dosage, and sensitivity analysis revealed that the TG-lowering effect of chitosan was statistically unstable.</div></div><div><h3>Conclusion</h3><div>Chitosan is associated with statistically significant but clinically negligible reductions in LDL-C, TG, and TC, and has no meaningful effect on HDL-C. The overall certainty of evidence was moderate for LDL-C and low for HDL-C, TG, and TC. Better-designed, larger, and longer trials are needed to confirm its safety and effectiveness as a lipid-lowering supplement.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102578"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145516756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ampelopsin's mechanism in ameliorating acute lung injury: Insights from network pharmacology and experimental validation","authors":"Chaohui Yan ,&nbsp;Xi Luo ,&nbsp;Yiwen Tang,&nbsp;Hong Chen,&nbsp;Shiting Qin,&nbsp;Yumei Huang,&nbsp;Chunhui Zeng,&nbsp;Ke Yang","doi":"10.1016/j.eujim.2025.102571","DOIUrl":"10.1016/j.eujim.2025.102571","url":null,"abstract":"<div><h3>Background</h3><div>Novel, effective, and safe therapeutic strategies are urgently needed to overcome conventional acute lung injury (ALI) treatment limitations. This study combined network pharmacology and experimental verification to explore the relationship between Ampelopsin (APS) and ALI molecular pathways, and to elucidate the key mechanism of APS in attenuating ALI.</div></div><div><h3>Methods</h3><div>The Swiss Target Prediction, Traditional Chinese Medicine Systems Pharmacology, DisGeNET, and GeneCards databases were used to predict the targets of APS to attenuate ALI. Potential targets were imported into the Metascape database to perform protein-protein interaction network, Gene ontology, and Kyoto encyclopedia of genes and genomes analyses, and a “drug - target - disease - access network” was established. Molecular docking of APS with key targets was performed using PyMOL and AutoDock. Validation experiments were performed using a lipopolysaccharide (LPS)-induced ALI mouse model, LPS-induced inflammatory A549 cells, and molecular docking between active compounds of APS and potential targets.</div></div><div><h3>Results</h3><div>Network pharmacology analysis identified six key targets (AKT1, AKT2, epidermal growth factor receptor, HRAS, IGF1R, and KDR) of APS to attenuate ALI, which were mainly involved in biological processes, such as cell migration and movement, regulation of kinase activity, and PI3K-Akt signaling pathway. Molecular docking analysis revealed that APS binds the key targets with binding energy ranging from -4.37 to -2.26. Further experiments revealed that APS could reduce pulmonary edema by reducing inflammatory factor release and regulate oxidative stress and autophagy, thus protecting LPS-induced ALI mice and A549 cells.</div></div><div><h3>Conclusions</h3><div>APS regulates inflammation and oxidative stress via the PI3K-Akt signaling pathway, thus retarding ALI progression.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102571"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145413564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study protocol for a randomised feasibility trial of self-acupuncture for patients with migraines (SAM)","authors":"Catrina Davy ,&nbsp;Michael Loughlin ,&nbsp;John Hughes","doi":"10.1016/j.eujim.2025.102573","DOIUrl":"10.1016/j.eujim.2025.102573","url":null,"abstract":"<div><h3>Introduction</h3><div>Ten sessions of acupuncture are recommended in the UK National Institute for Health and Care Excellence guidelines for the prophylactic treatment of migraines. However, ongoing or maintenance treatment is not recommended. Teaching people self-acupuncture (SA) may help people to manage their migraines. To date, there is no research examining SA in the management of migraines.</div></div><div><h3>Methods</h3><div>This study will examine the feasibility of all aspects of a trial of SA for patients who have previously found acupuncture beneficial to manage their migraines. This will include preliminary data on the size of any effect, participants’ views on the trial design and intervention, and any safety issues. The findings will determine the methodology for a subsequent RCT to examine the efficacy of SA to treat migraines.</div><div>The trial will employ a pragmatic, mixed-methods, randomised, parallel-group, exploratory design. The trial will compare SA plus standard care versus standard care alone. The trial aims to recruit 60 participants: 40 randomised to the SA group and 20 to the standard care group. Participants will be eligible if they have had a course of at least six acupuncture sessions to manage their migraines at the Royal London Hospital for Integrated Medicine, UK and found the treatments effective. Participants will complete outcome measures at various time points and take part in a qualitative interview to explore their views on the design of the trial and acceptability of SA. The researcher will observe and take field notes of the teaching session to explore the acceptability of the SA teaching method. Data will be analysed to determine if the trial design is feasible.</div></div><div><h3>Trial registration information</h3><div>ClinicalTrials.gov <span><span>https://clinicaltrials.gov/study/NCT06716944?cond=migraine&amp;intr=acupuncture&amp;rank=1</span><svg><path></path></svg></span> NCT06716944</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102573"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145413563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative approaches to eye health and disease","authors":"Mojtaba Heydari ,&nbsp;Mohammad Hashem Hashempur","doi":"10.1016/j.eujim.2025.102587","DOIUrl":"10.1016/j.eujim.2025.102587","url":null,"abstract":"<div><div>NA</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102587"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145681378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of curcumin in tissue engineering and nanotechnology-based drug delivery systems: A bibliometric analysis","authors":"Kaan ZIKŞAHNA ,&nbsp;Rumeysa ADIYIL ,&nbsp;Melisa ÖZKAN ,&nbsp;Murat IHLAMUR","doi":"10.1016/j.eujim.2025.102575","DOIUrl":"10.1016/j.eujim.2025.102575","url":null,"abstract":"<div><h3>Introduction</h3><div>Curcumin is widely investigated in tissue engineering and nanotechnology-enabled drug delivery, yet the rapidly expanding literature lacks a consolidated map to guide translation. To address this gap, we mapped global output, hotspots, and collaboration patterns on curcumin and aligned bibliometric trends with translational needs.</div></div><div><h3>Methods</h3><div>We conducted a Scopus-based bibliometric analysis of records published between 1997 and 2024 using a single-day snapshot (21 February 2025). A reproducible TITLE-ABS-KEY query centered on “curcumin” retrieved 12,327 documents. After retrieval, de-noising retained records that mentioned curcumin (or variants) in the title, abstract, or author keywords. We computed standard indicators (outputs, citations, subject areas, countries, institutions, authors, journals) and constructed keyword co-occurrence and collaboration networks in VOSviewer.</div></div><div><h3>Results</h3><div>Outputs increased sharply after 2016 and concentrated on pharmacology, biochemistry, materials science, and engineering. China (28.1 %), India (21.5 %), and the United States (12.6 %) led publication counts. Recurrent hotspots included bioavailability/controlled release, apoptosis/reactive oxygen species (ROS), hydrogels/nanofibers, and neuroprotection. Collaboration maps showed dense hubs around China, India, and the United States, while several regions were underrepresented.</div></div><div><h3>Conclusion</h3><div>Hotspots mirror experimental advances with nanocarriers such as PLGA, liposomes, and dendrosomes that improve curcumin stability, uptake, and therapeutic indices. Methodological transparency (single-source justification, query disclosure, de-noising) enhances reproducibility. Translational progress will benefit from harmonized in vivo models, full formulation reporting—size, polydispersity index (PDI), zeta potential, loading, and release—Good Manufacturing Practice (GMP)-compatible scale-up, and region-adapted regulatory guidance.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"80 ","pages":"Article 102575"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}