Pub Date : 2024-07-29DOI: 10.1016/j.eujim.2024.102391
Jacqueline James , Joseph T Costello , Amy K Drahota
Introduction
Reflexology is a complementary therapy based on the theory that different points on the feet, hands, face, and ears correspond with areas of the body, each being represented as a reflex. Different reflexology practises exist, and there is not one ‘standard’ approach. Not all reflexology studies are documented to a sufficiently high standard to allow research studies to be replicated and their data combined within meta-analysis, which would support a move to evidence-based practice for this complementary therapy. To identify specific shortfalls within reflexology intervention reporting, and to provide a benchmark which could be used to measure any future changes in the detail included in reflexology intervention reporting, the Template for Intervention Description and Replication (TIDieR) checklist has been used to assess the current situation.
Methods
A systematic review was carried out on studies published in 2021 and each study scored using the 12 TIDieR elements for compliance.
Results
A total of 420 references were identified, resulting in 41 eligible studies. Amongst the 12 TIDieR elements assessed, four elements (2: Why, 6: How, 7: Where, and 8: When and how much) were consistently addressed satisfactorily by the majority of the studies. Two elements (9: Tailoring and 12: How well actual) exhibited moderate levels of compliance, four TIDieR elements (1: Brief name, 3: What materials, 4: What procedures, and 5: Who) were predominantly addressed inadequately across the studies and two elements (10: Modifications and 11: How well planned) were rarely included in the studies analysed.
Conclusion
Many studies did not adequately report the reflexology intervention, which inhibits implementation (and discontinuation), replication, and research synthesis. This systematic review has identified the specific areas of the intervention which are not being documented with sufficient detail in order to highlight areas requiring improvement and produce a benchmark against which the quality of the intervention reporting can be measured in future studies. Data collected as part of this review have been used as input into a follow-up study which has produced reflexology specific guidance to be used with the TIDieR checklist.
{"title":"A benchmark for the quality of reflexology intervention reporting using the template for intervention description and replication (TIDieR) checklist: A systematic review","authors":"Jacqueline James , Joseph T Costello , Amy K Drahota","doi":"10.1016/j.eujim.2024.102391","DOIUrl":"10.1016/j.eujim.2024.102391","url":null,"abstract":"<div><h3>Introduction</h3><div>Reflexology is a complementary therapy based on the theory that different points on the feet, hands, face, and ears correspond with areas of the body, each being represented as a reflex. Different reflexology practises exist, and there is not one ‘standard’ approach. Not all reflexology studies are documented to a sufficiently high standard to allow research studies to be replicated and their data combined within meta-analysis, which would support a move to evidence-based practice for this complementary therapy. To identify specific shortfalls within reflexology intervention reporting, and to provide a benchmark which could be used to measure any future changes in the detail included in reflexology intervention reporting, the Template for Intervention Description and Replication (TIDieR) checklist has been used to assess the current situation.</div></div><div><h3>Methods</h3><div>A systematic review was carried out on studies published in 2021 and each study scored using the 12 TIDieR elements for compliance.</div></div><div><h3>Results</h3><div>A total of 420 references were identified, resulting in 41 eligible studies. Amongst the 12 TIDieR elements assessed, four elements (2: Why, 6: How, 7: Where, and 8: When and how much) were consistently addressed satisfactorily by the majority of the studies. Two elements (9: Tailoring and 12: How well actual) exhibited moderate levels of compliance, four TIDieR elements (1: Brief name, 3: What materials, 4: What procedures, and 5: Who) were predominantly addressed inadequately across the studies and two elements (10: Modifications and 11: How well planned) were rarely included in the studies analysed.</div></div><div><h3>Conclusion</h3><div>Many studies did not adequately report the reflexology intervention, which inhibits implementation (and discontinuation), replication, and research synthesis. This systematic review has identified the specific areas of the intervention which are not being documented with sufficient detail in order to highlight areas requiring improvement and produce a benchmark against which the quality of the intervention reporting can be measured in future studies. Data collected as part of this review have been used as input into a follow-up study which has produced reflexology specific guidance to be used with the TIDieR checklist.</div></div><div><h3>Funding</h3><div>No funding was received for this project.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"71 ","pages":"Article 102391"},"PeriodicalIF":1.9,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187638202400060X/pdfft?md5=51ce1557fe5527f0ebaa6284cdbdda2b&pid=1-s2.0-S187638202400060X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-25DOI: 10.1016/j.eujim.2024.102389
Yufang Zou, Hongfang Xu
<div><h3>Introduction</h3><p>Chronic kidney disease is a condition with high morbidity and mortality, and long-term renal replacement therapy also increases the risks of intradialytic hypertension. We aimed to evaluate the efficacy and safety of auricular acupressure in patients with chronic kidney disease undergoing intradialytic hypertension, regarding hypertension and reduction of complications of hemodialysis.</p></div><div><h3>Methods</h3><p>Three English and four Chinese databases were searched until September 21st, 2022. Inclusion criteria were auricular acupressure as the only complementary adjuvant in the experimental group and control intervention of blank control. Primary outcomes included systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Risk of bias of the included trials was evaluated using the Cochrane risk-of-bias tool. The review and meta-analyses were conducted using the Cochrane systematic review method, and trial sequential analyses were performed using TSA 0.9. Meta-influence analyses, subgroup analyses, meta-regression, and evaluation of publication bias were performed to explore the heterogeneity. The certainty of evidence was assessed using the GRADE-pro GDT.</p></div><div><h3>Results</h3><p>A total of 17 trials involving 1,288 participants were included. The results showed that auricular acupressure, as a complementary intervention, yielded significantly (<em>p</em> < 0.05) greater reductions in systolic blood pressure (WMD 10.84 mmHg, 95 %CI:9.37–12.32, <em>P</em> < 0.001, <em>I<sup>2</sup></em>=33 %, low certainty), diastolic blood pressure (WMD 8.20 mmHg, 95 %CI:6.36–10.04, <em>P</em> < 0.001, <em>I<sup>2</sup></em>=57 %, very low certainty), and mean arterial pressure (WMD 7.87 mmHg, 95 %CI:5.00–10.74, <em>P</em> < 0.001, <em>I<sup>2</sup></em> = 0 %, very low certainty) when performed with conventional interventions compared with conventional interventions alone. Results also revealed better relief from hemodialysis complications in the experimental group, including arrhythmias (RR 0.27, 95 %CI:0.16–0.45, <em>P</em> < 0.001, <em>I<sup>2</sup></em>=0 %, very low certainty), heart failure (RR 0.38, 95 %CI:0.25–0.59, <em>P</em> < 0.001, <em>I<sup>2</sup></em> = 0 %, very low certainty), nausea and dizziness (RR 0.51, 95 %CI:0.33–0.77, <em>P</em> = 0.001, <em>I<sup>2</sup></em> = 0 %, very low certainty), and dizziness alone (RR 0.16, 95 %CI:0.05–0.50, <em>P</em> = 0.002, <em>I<sup>2</sup></em> = 0 %, low certainty).</p></div><div><h3>Conclusion</h3><p>In general, auricular acupressure is safe and efficacious in patients with chronic kidney disease undergoing intradialytic hypertension, considering reduction in blood pressure and hemodialysis-induced complications. However, limitations of this review include risk of bias (including publication bias) in included studies, and a need for more inclusive studies with longer intervention and follow-up periods, and better global re
{"title":"Auricular acupressure for patients with chronic kidney disease undergoing intradialytic hypertension: A systematic review and meta-analysis with trial sequential analysis","authors":"Yufang Zou, Hongfang Xu","doi":"10.1016/j.eujim.2024.102389","DOIUrl":"10.1016/j.eujim.2024.102389","url":null,"abstract":"<div><h3>Introduction</h3><p>Chronic kidney disease is a condition with high morbidity and mortality, and long-term renal replacement therapy also increases the risks of intradialytic hypertension. We aimed to evaluate the efficacy and safety of auricular acupressure in patients with chronic kidney disease undergoing intradialytic hypertension, regarding hypertension and reduction of complications of hemodialysis.</p></div><div><h3>Methods</h3><p>Three English and four Chinese databases were searched until September 21st, 2022. Inclusion criteria were auricular acupressure as the only complementary adjuvant in the experimental group and control intervention of blank control. Primary outcomes included systolic blood pressure, diastolic blood pressure, and mean arterial pressure. Risk of bias of the included trials was evaluated using the Cochrane risk-of-bias tool. The review and meta-analyses were conducted using the Cochrane systematic review method, and trial sequential analyses were performed using TSA 0.9. Meta-influence analyses, subgroup analyses, meta-regression, and evaluation of publication bias were performed to explore the heterogeneity. The certainty of evidence was assessed using the GRADE-pro GDT.</p></div><div><h3>Results</h3><p>A total of 17 trials involving 1,288 participants were included. The results showed that auricular acupressure, as a complementary intervention, yielded significantly (<em>p</em> < 0.05) greater reductions in systolic blood pressure (WMD 10.84 mmHg, 95 %CI:9.37–12.32, <em>P</em> < 0.001, <em>I<sup>2</sup></em>=33 %, low certainty), diastolic blood pressure (WMD 8.20 mmHg, 95 %CI:6.36–10.04, <em>P</em> < 0.001, <em>I<sup>2</sup></em>=57 %, very low certainty), and mean arterial pressure (WMD 7.87 mmHg, 95 %CI:5.00–10.74, <em>P</em> < 0.001, <em>I<sup>2</sup></em> = 0 %, very low certainty) when performed with conventional interventions compared with conventional interventions alone. Results also revealed better relief from hemodialysis complications in the experimental group, including arrhythmias (RR 0.27, 95 %CI:0.16–0.45, <em>P</em> < 0.001, <em>I<sup>2</sup></em>=0 %, very low certainty), heart failure (RR 0.38, 95 %CI:0.25–0.59, <em>P</em> < 0.001, <em>I<sup>2</sup></em> = 0 %, very low certainty), nausea and dizziness (RR 0.51, 95 %CI:0.33–0.77, <em>P</em> = 0.001, <em>I<sup>2</sup></em> = 0 %, very low certainty), and dizziness alone (RR 0.16, 95 %CI:0.05–0.50, <em>P</em> = 0.002, <em>I<sup>2</sup></em> = 0 %, low certainty).</p></div><div><h3>Conclusion</h3><p>In general, auricular acupressure is safe and efficacious in patients with chronic kidney disease undergoing intradialytic hypertension, considering reduction in blood pressure and hemodialysis-induced complications. However, limitations of this review include risk of bias (including publication bias) in included studies, and a need for more inclusive studies with longer intervention and follow-up periods, and better global re","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"70 ","pages":"Article 102389"},"PeriodicalIF":1.9,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.1016/j.eujim.2024.102392
Xuan Zhou , Mengying Li , Minjie Zhang , Yang Zhang
Introduction
Traditional Chinese medicine (TCM) has unique advantages in treating diabetic osteoporosis (DOP). This study aimed to explore the mechanisms underlying the protective effects of herb couplet medicines (Erxian) on DOP using network pharmacology and verify these mechanisms using cell experiments.
Methods
We used chromatography to analyze the bioactive components of serum containing Erxian couplet medicines (ECMs) and searched for possible targets of the active ingredients in the Traditional Chinese Medicine Systems Pharmacology database. The target proteins of DOP were retrieved from the GeneCards and Online Mendelian Inheritance in Man databases. A component-target network diagram was then constructed using the screened drug components and target information for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. In vitro, cell morphological changes were observed using alkaline phosphatase staining, and the effect of the ECMs on osteoblast viability was assessed using a cell counting kit-8 assay. Finally, the pathway information predicted by network pharmacology was validated using flow cytometry, real-time polymerase chain reaction, and western blot experiments.
Results
Twelve types of active ingredients in serum containing ECMs were obtained via chromatography, and 96 potential targets were identified using network pharmacology analysis. Furthermore, GO and KEGG pathway enrichment analyses revealed that the ECMs might participate in the apoptosis signaling pathway in the treatment of DOP. In vitro tests showed that treatment with ECM serum increased osteoblasts’ survival rate and improved the HG group's cell morphology (P < 0.05). BCL2-associated X protein (BAX) expression increased in the HG group but decreased after ECM serum addition (P < 0.05). The expression of B-cell lymphoma-2 (BCL-2) was found to be reduced in the HG group but increased after ECM serum addition (P < 0.05).
Conclusion
ECMs can treat DOP via multiple targets and multiple signaling pathways. Moreover, the mechanism underlying the effects of ECMs on osteoblasts was verified by inhibiting apoptotic. The complete signaling pathway requires future study.
{"title":"Herb couplet medicines (Erxian) protect osteoblasts from high glucose-induced damage by reducing cell apoptosis in diabetic osteoporosis: A network pharmacology and experimental verification-based study","authors":"Xuan Zhou , Mengying Li , Minjie Zhang , Yang Zhang","doi":"10.1016/j.eujim.2024.102392","DOIUrl":"10.1016/j.eujim.2024.102392","url":null,"abstract":"<div><h3>Introduction</h3><p>Traditional Chinese medicine (TCM) has unique advantages in treating diabetic osteoporosis (DOP). This study aimed to explore the mechanisms underlying the protective effects of herb couplet medicines (Erxian) on DOP using network pharmacology and verify these mechanisms using cell experiments.</p></div><div><h3>Methods</h3><p>We used chromatography to analyze the bioactive components of serum containing Erxian couplet medicines (ECMs) and searched for possible targets of the active ingredients in the Traditional Chinese Medicine Systems Pharmacology database. The target proteins of DOP were retrieved from the GeneCards and Online Mendelian Inheritance in Man databases. A component-target network diagram was then constructed using the screened drug components and target information for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. <em>In vitro</em>, cell morphological changes were observed using alkaline phosphatase staining, and the effect of the ECMs on osteoblast viability was assessed using a cell counting kit-8 assay. Finally, the pathway information predicted by network pharmacology was validated using flow cytometry, real-time polymerase chain reaction, and western blot experiments.</p></div><div><h3>Results</h3><p>Twelve types of active ingredients in serum containing ECMs were obtained via chromatography, and 96 potential targets were identified using network pharmacology analysis. Furthermore, GO and KEGG pathway enrichment analyses revealed that the ECMs might participate in the apoptosis signaling pathway in the treatment of DOP. <em>In vitro</em> tests showed that treatment with ECM serum increased osteoblasts’ survival rate and improved the HG group's cell morphology (<em>P</em> < 0.05). BCL2-associated X protein (BAX) expression increased in the HG group but decreased after ECM serum addition (<em>P</em> < 0.05). The expression of B-cell lymphoma-2 (BCL-2) was found to be reduced in the HG group but increased after ECM serum addition (<em>P</em> < 0.05).</p></div><div><h3>Conclusion</h3><p>ECMs can treat DOP via multiple targets and multiple signaling pathways. Moreover, the mechanism underlying the effects of ECMs on osteoblasts was verified by inhibiting apoptotic. The complete signaling pathway requires future study.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"70 ","pages":"Article 102392"},"PeriodicalIF":1.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382024000611/pdfft?md5=b4332bcaf453e13a8fb5f86481d20f8f&pid=1-s2.0-S1876382024000611-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-24DOI: 10.1016/j.eujim.2024.102390
Asmita Patel, Robyn Carruthers, Karen Wesseling, Karen Mees, Wayne Hill
Introduction
Naturopathy is a well-known and utilised form of traditional, complementary, and integrative medicine (TCIM). Limited New Zealand research exists that has examined the utilisation of naturopathy from the perspective of users. The present study was designed to identify and explore individual's experiences and perceptions of naturopathic care.
Methods
Twenty clients (18 female and two male) who attended a student naturopathy and herbal medicine teaching clinic in Auckland, New Zealand were individually interviewed via Zoom video conferencing using open-ended questions. Interview transcripts were anlysed using an inductive thematic approach, focusing on similarities in participants' experiences and perceptions of their naturopathic treatment.
Results
Six main themes were identified regarding individual's experiences and perceptions of naturopathic care (1) feeling heard, (2) perceived attributes of the student practitioner and feeling looked after, (3) perceived knowledge of student practitioners, (4) high degree of client education, (5) partnership, empowerment and ownership, and (6) recommending naturopathy based on own experiences.
Conclusions
Participants reported positive experiences and perceptions of their naturopathic treatment. Participants felt heard and looked after and indicated that their student naturopaths were caring, supportive and knowledgeable. Client education enhanced health literacy and participants felt empowered and in control of their health and healing. Client education was perceived to be important for individuals with chronic health conditions, as the information imparted was not always covered by their other healthcare practitioners.
{"title":"Client experiences and perceptions of naturopathic treatment in New Zealand: A qualitative study","authors":"Asmita Patel, Robyn Carruthers, Karen Wesseling, Karen Mees, Wayne Hill","doi":"10.1016/j.eujim.2024.102390","DOIUrl":"10.1016/j.eujim.2024.102390","url":null,"abstract":"<div><h3>Introduction</h3><p>Naturopathy is a well-known and utilised form of traditional, complementary, and integrative medicine (TCIM). Limited New Zealand research exists that has examined the utilisation of naturopathy from the perspective of users. The present study was designed to identify and explore individual's experiences and perceptions of naturopathic care.</p></div><div><h3>Methods</h3><p>Twenty clients (18 female and two male) who attended a student naturopathy and herbal medicine teaching clinic in Auckland, New Zealand were individually interviewed via Zoom video conferencing using open-ended questions. Interview transcripts were anlysed using an inductive thematic approach, focusing on similarities in participants' experiences and perceptions of their naturopathic treatment.</p></div><div><h3>Results</h3><p>Six main themes were identified regarding individual's experiences and perceptions of naturopathic care (1) feeling heard, (2) perceived attributes of the student practitioner and feeling looked after, (3) perceived knowledge of student practitioners, (4) high degree of client education, (5) partnership, empowerment and ownership, and (6) recommending naturopathy based on own experiences.</p></div><div><h3>Conclusions</h3><p>Participants reported positive experiences and perceptions of their naturopathic treatment. Participants felt heard and looked after and indicated that their student naturopaths were caring, supportive and knowledgeable. Client education enhanced health literacy and participants felt empowered and in control of their health and healing. Client education was perceived to be important for individuals with chronic health conditions, as the information imparted was not always covered by their other healthcare practitioners.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"70 ","pages":"Article 102390"},"PeriodicalIF":1.9,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.1016/j.eujim.2024.102388
András Béres
Introduction
Whether traditional East Asian medicine (TEAM) is compatible with biomedicine remains controversial, with biomedicine research failing to explain key TEAM concepts. This article hypothesizes that reconciliation could be effective if biomedicine assumed that it examines a limited portion of reality, whereas Eastern medicine aims to conceptualize reality in its entirety. Re-discovering elements of Western thought that allow epistemological expansion, such as the notion of a non-material aspect inherent to all phenomena, and its implications for research methodology, can encourage biomedical research to reflect on TEAM.
Approach
The article reviews sources from the Western and Eastern medical literature to explore the above hypothesis.
Discussion
The concept of Qi (氣), inherent in TEAM's interpretive framework, lays the foundations for theoretical compatibility and a practical integrative approach. In TEAM, Qi is the basic fabric from which all things are made; however, holding that all things have a non-material aspect is also deeply rooted in the European religious and philosophical tradition. This article proposes that biomedicine detects the denser part of the Qi spectrum conceived by TEAM. As an illness progresses, parts of Qi that make up the organism become increasingly separated, but biomedicine detects disharmony only when the magnitude reaches a certain level owing to its sensitivity range.
Conclusion
Both TEAM and biomedicine consider the patient's complaint as an unquestionable reality that medicine can observe and aims to alleviate. TEAM assumes that traditions distilled over millennia require verification through evidence-based medicine to gain credibility in the West, which owes its success to its skeptical attitude. Meanwhile, biomedicine assumes that some mechanisms that influence health and healing may not be measurable by current biomedical devices. However, this does not mean that these mechanisms cannot be verified, albeit with an emphasis on patients’ subjective experiences. The theoretical compatibility of TEAM and biomedicine creates sufficient legitimacy for their co-existence, and research on their sequential, rather than alternative or complementary, use in healthcare is needed.
导言：传统东亚医学（TEAM）与生物医学是否兼容仍存在争议，生物医学研究未能解释传统东亚医学的关键概念。本文假设，如果生物医学认为自己只研究了现实中有限的一部分，而东亚医学则旨在将现实的全部概念化，那么两者之间的调和就会有效。重新发掘西方思想中允许认识论扩展的元素，如所有现象固有的非物质方面的概念及其对研究方法论的影响，可以鼓励生物医学研究对 TEAM 进行反思。讨论TEAM 解释框架中固有的气（Qi）概念为理论兼容性和实际整合方法奠定了基础。在 TEAM 中，"气 "是构成万物的基本结构；然而，认为万物都有非物质的一面也深深植根于欧洲的宗教和哲学传统。本文建议生物医学检测 TEAM 所设想的 "气 "光谱中较稠密的部分。随着疾病的发展，构成机体的 "气 "的各个部分变得越来越分离，但生物医学由于其灵敏度范围，只有当不和谐的程度达到一定程度时才能检测到。TEAM 认为，几千年来形成的传统需要通过循证医学的验证才能在西方获得公信力，而西方的成功得益于其持怀疑态度。同时，生物医学认为，一些影响健康和治疗的机制可能无法通过现有的生物医学设备来测量。然而，这并不意味着这些机制无法得到验证，尽管要强调病人的主观体验。TEAM 和生物医学在理论上的兼容性为它们的共存提供了充分的合法性，因此需要对它们在医疗保健中的使用顺序而非替代或互补性进行研究。
{"title":"Revisiting the relationship between traditional East Asian medicine and biomedicine: Incorporating the Western into the Eastern","authors":"András Béres","doi":"10.1016/j.eujim.2024.102388","DOIUrl":"10.1016/j.eujim.2024.102388","url":null,"abstract":"<div><h3>Introduction</h3><p>Whether traditional East Asian medicine (TEAM) is compatible with biomedicine remains controversial, with biomedicine research failing to explain key TEAM concepts. This article hypothesizes that reconciliation could be effective if biomedicine assumed that it examines a limited portion of reality, whereas Eastern medicine aims to conceptualize reality in its entirety. <em>Re</em>-discovering elements of Western thought that allow epistemological expansion, such as the notion of a non-material aspect inherent to all phenomena, and its implications for research methodology, can encourage biomedical research to reflect on TEAM.</p></div><div><h3>Approach</h3><p>The article reviews sources from the Western and Eastern medical literature to explore the above hypothesis.</p></div><div><h3>Discussion</h3><p>The concept of Qi (氣), inherent in TEAM's interpretive framework, lays the foundations for theoretical compatibility and a practical integrative approach. In TEAM, Qi is the basic fabric from which all things are made; however, holding that all things have a non-material aspect is also deeply rooted in the European religious and philosophical tradition. This article proposes that biomedicine detects the denser part of the Qi spectrum conceived by TEAM. As an illness progresses, parts of Qi that make up the organism become increasingly separated, but biomedicine detects disharmony only when the magnitude reaches a certain level owing to its sensitivity range.</p></div><div><h3>Conclusion</h3><p>Both TEAM and biomedicine consider the patient's complaint as an unquestionable reality that medicine can observe and aims to alleviate. TEAM assumes that traditions distilled over millennia require verification through evidence-based medicine to gain credibility in the West, which owes its success to its skeptical attitude. Meanwhile, biomedicine assumes that some mechanisms that influence health and healing may not be measurable by current biomedical devices. However, this does not mean that these mechanisms cannot be verified, albeit with an emphasis on patients’ subjective experiences. The theoretical compatibility of TEAM and biomedicine creates sufficient legitimacy for their co-existence, and research on their sequential, rather than alternative or complementary, use in healthcare is needed.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"70 ","pages":"Article 102388"},"PeriodicalIF":1.9,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S187638202400057X/pdfft?md5=b7f8e268515f241535915f60e34146d8&pid=1-s2.0-S187638202400057X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141846701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dry eye disease (DED) has become increasingly prevalent in ophthalmology, significantly impacting patients' quality of life. Despite the widespread use of acupuncture therapies in treating DED, the most effective acupuncture treatment strategy remains uncertain. This study aimed to provide guidance in clinical practice for selecting the most effective acupuncture treatment strategy using the network meta-analysis (NMA) method.
Methods
Seven English and Chinese databases were searched from their inception to October 15, 2023, to collect randomized controlled trials (RCTs) related to acupuncture therapies for treating DED. The risk of bias was assessed using the revised Cochrane risk of bias tool (ROB 2.0). Network meta-analysis was conducted using R 4.1.2 and Stata 17.0. The Confidence in Network Meta-Analysis (CINeMA) tool was used to evaluate the certainty of evidence.
Results
A total of 41 studies with 2931 participants were included. The network meta-analysis results showed that conventional acupuncture combined with thumbtack needle had the best efficacy in improving tear break-up time (TBUT) (MD = 2.95, 95 % CI [1.49, 4.39]) and Schirmer's test (MD = 3.34, 95 % CI [0.90, 5.79]). In terms of improving the corneal fluorescein staining score, conventional acupuncture combined with electroacupuncture demonstrated the best efficacy (SMD = -0.80, 95 % CI [-1.40, -0.18]). The confidence ratings of different treatment comparisons were judged as very low to low. Eight studies reported adverse effects, none of which were serious.
Conclusion
The NMA results support the use of acupuncture for treating DED. Among the therapies, conventional acupuncture combined with thumbtack needle and conventional acupuncture combined with electroacupuncture have higher priority. However, before widespread adoption, more multicenter, randomized, double-blind, and placebo-controlled clinical trials are needed to confirm these findings.
导言干眼症（DED）在眼科中的发病率越来越高，严重影响了患者的生活质量。尽管针灸疗法被广泛应用于治疗 DED，但最有效的针灸治疗策略仍不确定。本研究旨在采用网络荟萃分析（NMA）方法，为临床实践中选择最有效的针灸治疗策略提供指导。方法检索了七个中英文数据库，收集了从开始到2023年10月15日与针灸疗法治疗DED相关的随机对照试验（RCT）。使用修订版科克伦偏倚风险工具（ROB 2.0）评估偏倚风险。网络荟萃分析使用 R 4.1.2 和 Stata 17.0 进行。网络荟萃分析工具（CINeMA）用于评估证据的确定性。网络荟萃分析结果显示，传统针灸结合拇指针在改善泪液破裂时间（TBUT）（MD = 2.95，95 % CI [1.49，4.39]）和Schirmer试验（MD = 3.34，95 % CI [0.90，5.79]）方面疗效最佳。在改善角膜荧光素染色评分方面，传统针灸结合电针的疗效最佳（SMD = -0.80，95 % CI [-1.40，-0.18]）。不同治疗方法比较的可信度被判定为极低至低。八项研究报告了不良反应，但均不严重。在各种疗法中，传统针灸结合拇指针和传统针灸结合电针具有更高的优先级。然而，在广泛采用之前，需要更多的多中心、随机、双盲和安慰剂对照临床试验来证实这些结果。
{"title":"Comparison of different acupuncture therapies for dry eye disease: A systematic review and network meta-analysis","authors":"Qingyuan Zhang , Shenghe Huang , Qianyan Wu , Jingwen Zhang , Yao Xiao , Shuailiang Huang , Xiaogang Xu , Delin Zhang","doi":"10.1016/j.eujim.2024.102387","DOIUrl":"10.1016/j.eujim.2024.102387","url":null,"abstract":"<div><h3>Introduction</h3><p>Dry eye disease (DED) has become increasingly prevalent in ophthalmology, significantly impacting patients' quality of life. Despite the widespread use of acupuncture therapies in treating DED, the most effective acupuncture treatment strategy remains uncertain. This study aimed to provide guidance in clinical practice for selecting the most effective acupuncture treatment strategy using the network meta-analysis (NMA) method.</p></div><div><h3>Methods</h3><p>Seven English and Chinese databases were searched from their inception to October 15, 2023, to collect randomized controlled trials (RCTs) related to acupuncture therapies for treating DED. The risk of bias was assessed using the revised Cochrane risk of bias tool (ROB 2.0). Network meta-analysis was conducted using R 4.1.2 and Stata 17.0. The Confidence in Network Meta-Analysis (CINeMA) tool was used to evaluate the certainty of evidence.</p></div><div><h3>Results</h3><p>A total of 41 studies with 2931 participants were included. The network meta-analysis results showed that conventional acupuncture combined with thumbtack needle had the best efficacy in improving tear break-up time (TBUT) (MD = 2.95, 95 % CI [1.49, 4.39]) and Schirmer's test (MD = 3.34, 95 % CI [0.90, 5.79]). In terms of improving the corneal fluorescein staining score, conventional acupuncture combined with electroacupuncture demonstrated the best efficacy (SMD = -0.80, 95 % CI [-1.40, -0.18]). The confidence ratings of different treatment comparisons were judged as very low to low. Eight studies reported adverse effects, none of which were serious.</p></div><div><h3>Conclusion</h3><p>The NMA results support the use of acupuncture for treating DED. Among the therapies, conventional acupuncture combined with thumbtack needle and conventional acupuncture combined with electroacupuncture have higher priority. However, before widespread adoption, more multicenter, randomized, double-blind, and placebo-controlled clinical trials are needed to confirm these findings.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"70 ","pages":"Article 102387"},"PeriodicalIF":1.9,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
<div><h3>Introduction</h3><p>Diverse disease courses, each corresponding to a unique pathophysiological mechanism, characterize the coronavirus 2019 disease (COVID-19). Intensive research on discovering specificity targets for treating COVID-19 has significant implications for understanding pathogenesis mechanisms in disease evolution. Traditional Chinese medicine (TCM) has shown distinctive advantages in treating COVID-19 in different periods, which may provide new clues for target discovery. In order to accomplish the goal of providing a Disease Evolution-based Specificity Target Discovery (DESTD), the purpose of this paper was to conduct an analysis of the difference in target weighted value during each cycle of COVID-19.</p></div><div><h3>Methods</h3><p>Our study employed a comprehensive methodology combining TCM pharmacology with modern biological techniques. Three Jiawei-Maxing-Shigan Decoctions (MS Decoction), were selected as samples, including Hanshi-Yufei decoction (HY Decoction), Shidu-Yufei decoction (SY Decoction), and Yidu-Bifei decoction (YB Decoction). The core components of these decoctions are the same, while the differences correspond to different periods of COVID-19. The DESTD approach consists of several parts: network pharmacology analysis to identify potential targets, molecular docking simulation to investigate TCM components acting on potential targets, and biological validation. This study employed several cell line models, including RAW264.7 (Mouse Mononuclear Macrophages Cells), 16HBE (Human Bronchial Epithelial Cells), and HUVEC<img>C (Human Umbilical Vein Endothelial Cells), to explore new approaches for key target discovery.</p></div><div><h3>Results</h3><p>During the mild phase of COVID-19, HY Decoction exhibited anti-inflammatory effects by specifically down-regulating the expression of heat shock protein HSP 90-alpha (<em>HSP90AA1</em>), transcription factor JUN (<em>JUN</em>) and other five genes in RAW264.7. In the common phrase, inflammation and fibrosis could be specifically alleviated by down-regulating the expression of interleukin-10 (<em>IL10</em>) and mitogen-activated protein kinase 14 (<em>MAPK14</em>) by SY Decoction respectively acting on RAW264.7 and 16HBE cell lines. In severe cases, YB Decoction specifically down-regulated the expression of prostaglandin endoperoxide synthase-2 (<em>PTGS2</em>), caspase-3 (<em>CASP3</em>), and three other genes to protect vascular endothelial cells from oxidative damage. Moreover, YB also played a role in anti-fibrosis by specifically down-regulating the expression of estrogen receptor beta (<em>ESR2</em>), vascular cell adhesion protein 1 (<em>VCAM1</em>), and other three genes, and up-regulating the expression of prostaglandin endoperoxide synthase-1 (<em>PTGS1</em>) in the severe period. These targeted actions align with a holistic treatment approach and provide tailored therapies for different stages of COVID-19.</p></div><div><h3>Conclusion</h3><p>This resear
{"title":"Disease Evolution-based Specificity Target Discovery (DESTD) by analyzing Jiawei-Maxing-Shigan Decoctions against COVID-19","authors":"Beiyan Li, Chaoqun Liu, Zhan Shu, Shijie Bi, Yue Ren, Kaiyang Liu, Anlei Yuan, Lulu Zheng, Zhenzhen Xu, Zewen Wang, Yanling Zhang","doi":"10.1016/j.eujim.2024.102386","DOIUrl":"10.1016/j.eujim.2024.102386","url":null,"abstract":"<div><h3>Introduction</h3><p>Diverse disease courses, each corresponding to a unique pathophysiological mechanism, characterize the coronavirus 2019 disease (COVID-19). Intensive research on discovering specificity targets for treating COVID-19 has significant implications for understanding pathogenesis mechanisms in disease evolution. Traditional Chinese medicine (TCM) has shown distinctive advantages in treating COVID-19 in different periods, which may provide new clues for target discovery. In order to accomplish the goal of providing a Disease Evolution-based Specificity Target Discovery (DESTD), the purpose of this paper was to conduct an analysis of the difference in target weighted value during each cycle of COVID-19.</p></div><div><h3>Methods</h3><p>Our study employed a comprehensive methodology combining TCM pharmacology with modern biological techniques. Three Jiawei-Maxing-Shigan Decoctions (MS Decoction), were selected as samples, including Hanshi-Yufei decoction (HY Decoction), Shidu-Yufei decoction (SY Decoction), and Yidu-Bifei decoction (YB Decoction). The core components of these decoctions are the same, while the differences correspond to different periods of COVID-19. The DESTD approach consists of several parts: network pharmacology analysis to identify potential targets, molecular docking simulation to investigate TCM components acting on potential targets, and biological validation. This study employed several cell line models, including RAW264.7 (Mouse Mononuclear Macrophages Cells), 16HBE (Human Bronchial Epithelial Cells), and HUVEC<img>C (Human Umbilical Vein Endothelial Cells), to explore new approaches for key target discovery.</p></div><div><h3>Results</h3><p>During the mild phase of COVID-19, HY Decoction exhibited anti-inflammatory effects by specifically down-regulating the expression of heat shock protein HSP 90-alpha (<em>HSP90AA1</em>), transcription factor JUN (<em>JUN</em>) and other five genes in RAW264.7. In the common phrase, inflammation and fibrosis could be specifically alleviated by down-regulating the expression of interleukin-10 (<em>IL10</em>) and mitogen-activated protein kinase 14 (<em>MAPK14</em>) by SY Decoction respectively acting on RAW264.7 and 16HBE cell lines. In severe cases, YB Decoction specifically down-regulated the expression of prostaglandin endoperoxide synthase-2 (<em>PTGS2</em>), caspase-3 (<em>CASP3</em>), and three other genes to protect vascular endothelial cells from oxidative damage. Moreover, YB also played a role in anti-fibrosis by specifically down-regulating the expression of estrogen receptor beta (<em>ESR2</em>), vascular cell adhesion protein 1 (<em>VCAM1</em>), and other three genes, and up-regulating the expression of prostaglandin endoperoxide synthase-1 (<em>PTGS1</em>) in the severe period. These targeted actions align with a holistic treatment approach and provide tailored therapies for different stages of COVID-19.</p></div><div><h3>Conclusion</h3><p>This resear","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"70 ","pages":"Article 102386"},"PeriodicalIF":1.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141701077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The use of complementary and alternative medicine, particularly herbal medicine, is increasing, especially in chronic disorders. This study aims to identify common herbal medicines used by patients with inflammatory bowel disease, and to investigate their relationship with the quality of life, disease severity, and levels of anxiety, stress, and depression experienced by these patients.
Methods
A total of 104 eligible patients with inflammatory bowel disease and in the middle years of life (20- 60 years old) participated in this cross-sectional study. Data collection was conducted using various assessment tools, i.e. a self-administered ethnomedicine questionnaire, Partial Mayo scoring index assessment, Crohn's disease activity index, Quality of Life Questionnaire, and Depression, Anxiety and Stress Scale.
Results
The findings of the present study revealed that 61.5% of the patients surveyed commonly used herbal medicine to alleviate their symptoms in the past year. Among the various herbs, Matricaria chamomilla L., Zataria multiflora Boiss., and Mentha Spicata L. were found to be most commonly used. Furthermore, a significant association was identified between herbal medicine use and age, Body Mass Index, marital status, level of education, alcohol consumption, Quality of Life, and severity disorder scores of the patients.
Conclusion
Our results suggested a significant association between herbal medicine use and lower severity disorder scores and higher quality of life in patients with inflammatory bowel disease. However, these findings may not be generalizable to all patients with inflammatory bowel disease, or to patients in other geographical regions.
{"title":"The use of herbal medicine in patients with inflammatory bowel disorders in Iran: A cross-sectional study","authors":"Ebrahim Shamsaddini , Fatemeh Sadat Hasheminasab , Mahboobeh Raeiszadeh , Saiedeh Haji-Maghsoudi , Ahmad Azizian , Maryam Azimi","doi":"10.1016/j.eujim.2024.102384","DOIUrl":"10.1016/j.eujim.2024.102384","url":null,"abstract":"<div><h3>Introduction</h3><div>The use of complementary and alternative medicine, particularly herbal medicine, is increasing, especially in chronic disorders. This study aims to identify common herbal medicines used by patients with inflammatory bowel disease, and to investigate their relationship with the quality of life, disease severity, and levels of anxiety, stress, and depression experienced by these patients.</div></div><div><h3>Methods</h3><div>A total of 104 eligible patients with inflammatory bowel disease and in the middle years of life (20- 60 years old) participated in this cross-sectional study. Data collection was conducted using various assessment tools, i.e. a self-administered ethnomedicine questionnaire, Partial Mayo scoring index assessment, Crohn's disease activity index, Quality of Life Questionnaire, and Depression, Anxiety and Stress Scale.</div></div><div><h3>Results</h3><div>The findings of the present study revealed that 61.5% of the patients surveyed commonly used herbal medicine to alleviate their symptoms in the past year. Among the various herbs, <em>Matricaria chamomilla</em> L<em>., Zataria multiflora</em> Boiss., and <em>Mentha Spicata</em> L. were found to be most commonly used. Furthermore, a significant association was identified between herbal medicine use and age, Body Mass Index, marital status, level of education, alcohol consumption, Quality of Life, and severity disorder scores of the patients.</div></div><div><h3>Conclusion</h3><div>Our results suggested a significant association between herbal medicine use and lower severity disorder scores and higher quality of life in patients with inflammatory bowel disease. However, these findings may not be generalizable to all patients with inflammatory bowel disease, or to patients in other geographical regions.</div></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"71 ","pages":"Article 102384"},"PeriodicalIF":1.9,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-26DOI: 10.1016/j.eujim.2024.102382
Zicheng Wei , Zhen Liu , Hongjiao Wu , Kaizheng Wang , Shuang Wu , Lijiang Lv , Zhizhen Lv
Introduction
Infantile cerebral palsy (ICP) is a disease that causes cognitive and motor dysfunction in children, severely affecting their growth and mental health. Infantile tuina is a prominent treatment modality in traditional Chinese medicine (TCM). However, the effectiveness of infantile tuina remains uncertain. This systematic review aimed to assess the efficacy of infantile tuina in enhancing motor dysfunction in ICP through randomized controlled trials (RCTs).
Methods
We completed the meta-analysis according to the PRISMA 2020 checklist. Randomized controlled trials (RCTs) were searched for in seven databases including Medline, Ovid EMBASE, Cochrane Library, Web of Science, China national knowledge infrastructure, Chinese biomedical literature, and Wan Fang from the establishment of the database until November 7, 2023. The effectiveness of infantile tuina to treat motor dysfunction in children with spastic cerebral palsy was evaluated using outcome indexes such as effective rate, Gross motor function measure (GMFM), Modified Ashworth Scale (MAS), and ankle passive dorsiflexion angle.
Results
A total of 12 RCTs were included in this systematic review, which included 950 patients. Meta-analysis of the results indicated that infantile tuina combined with conventional rehabilitation treatment for ICP produced better results than conventional rehabilitation treatment alone. The experimental group intervention had a significant effect on the improvement of ICP treatment efficiency [Relative Risk (RR) = 1.21; 95% Confidence Interval (CI) = 1.10, 1.33], GMFM [MD = 4.76, 95% CI = 3.23, 3.29], MAS [Mean difference (MD) = -0.83, 95% CI = -1.02, -0.64], and ankle dorsiflexion angle [MD = -4.82, 95% CI = -7.45, -2.18]. The results were statistically significant (P < 0.05).
Conclusions
As a complementary therapy to conventional rehabilitation therapy, infantile tuina produced significant improvements in ICP treatment effectiveness in this systematic review. The main limitation in the evidence was a lack of high-quality studies and many studies had small sample sizes.
{"title":"Effectiveness of infantile tuina for improving motor dysfunction in children with spastic cerebral palsy: A systematic review and meta-analysis of randomized controlled trials","authors":"Zicheng Wei , Zhen Liu , Hongjiao Wu , Kaizheng Wang , Shuang Wu , Lijiang Lv , Zhizhen Lv","doi":"10.1016/j.eujim.2024.102382","DOIUrl":"10.1016/j.eujim.2024.102382","url":null,"abstract":"<div><h3>Introduction</h3><p>Infantile cerebral palsy (ICP) is a disease that causes cognitive and motor dysfunction in children, severely affecting their growth and mental health. Infantile tuina is a prominent treatment modality in traditional Chinese medicine (TCM). However, the effectiveness of infantile tuina remains uncertain. This systematic review aimed to assess the efficacy of infantile tuina in enhancing motor dysfunction in ICP through randomized controlled trials (RCTs).</p></div><div><h3>Methods</h3><p>We completed the meta-analysis according to the PRISMA 2020 checklist. Randomized controlled trials (RCTs) were searched for in seven databases including Medline, Ovid EMBASE, Cochrane Library, Web of Science, China national knowledge infrastructure, Chinese biomedical literature, and Wan Fang from the establishment of the database until November 7, 2023. The effectiveness of infantile tuina to treat motor dysfunction in children with spastic cerebral palsy was evaluated using outcome indexes such as effective rate, Gross motor function measure (GMFM), Modified Ashworth Scale (MAS), and ankle passive dorsiflexion angle.</p></div><div><h3>Results</h3><p>A total of 12 RCTs were included in this systematic review, which included 950 patients. Meta-analysis of the results indicated that infantile tuina combined with conventional rehabilitation treatment for ICP produced better results than conventional rehabilitation treatment alone. The experimental group intervention had a significant effect on the improvement of ICP treatment efficiency [Relative Risk (RR) = 1.21; 95% Confidence Interval (CI) = 1.10, 1.33], GMFM [MD = 4.76, 95% CI = 3.23, 3.29], MAS [Mean difference (MD) = -0.83, 95% CI = -1.02, -0.64], and ankle dorsiflexion angle [MD = -4.82, 95% CI = -7.45, -2.18]. The results were statistically significant (<em>P</em> < 0.05).</p></div><div><h3>Conclusions</h3><p>As a complementary therapy to conventional rehabilitation therapy, infantile tuina produced significant improvements in ICP treatment effectiveness in this systematic review. The main limitation in the evidence was a lack of high-quality studies and many studies had small sample sizes.</p></div><div><h3>Registration</h3><p>PROSPERO ID: CRD42023446889.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102382"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-22DOI: 10.1016/j.eujim.2024.102380
Yilin Liu , Xinling Zhao , Qing Long , Zeyi Guo , Xiang Cao , Xiaoqin Wu , Fangjun Tu , Yunqiao Zhang , Xu You , Xiuying Shi , Zhaowei Teng , Yong Zeng
Introduction
This study aimed to identify the target of action of Wendan decoction, a classical Chinese herbal formula used for the treatment of psychiatric disorders, specifically schizophrenia, using network pharmacology.
Methods
Traditional Chinese Medicine (TCM) bioinformatics and network pharmacology were employed to predict the genes regulated by miR-26b-5p and identify the active ingredients and related targets of the Wendan decoction from public databases. Key components and targets were screened by constructing a "TCM-component-target" network, followed by pathway enrichment analysis of the related targets. The expression levels of miR-26b-5p and prostaglandin-endoperoxide synthase 2 (PTGS2) in the peripheral blood of patients with schizophrenia patients and healthy individuals were determined using RT-qPCR. Molecular docking was performed to explore the interaction between the active ingredients of the Wendan decoction and key differentially expressed molecules, investigating the role of miR-26b-5p in the treatment of schizophrenia with the Wendan decoction.
Results
A total of 135 active constituents were extracted from the Wendan decoction, and 144 molecules, including PTGS2 and other derivatives, were screened for drug-target and disease-target inter-mapping. Compared to peripheral blood samples from healthy controls and patients with depression, peripheral blood samples from patients with schizophrenia patients showed low miR-26b-5p expression and elevated PTGS2 expression, with no significant difference observed in the expression between healthy controls and patients with depression. Molecular docking revealed that several active compounds were found in five of the six constituents of the Wendan decoction bound with PTGS2. Pathway enrichment analysis suggested that the Wendan decoction may have a potential therapeutic role in treating schizophrenia by regulating the circadian rhythm, N-methyl-d-aspartate glutamate receptor activity, inflammatory mediator regulation of transient receptor potential channels, and other pathways implicated in schizophrenia.
Conclusion
Wendan decoction may treat schizophrenia via the miR-26b-5p targeting factor PTGS2 and inflammation-related pathways. miR-26b-5p, combined with PTSG2, holds the potential as a differential diagnostic marker for schizophrenia.
{"title":"Investigating the role of miR-26b-5p and PTGS2 in schizophrenia treatment using Wendan decoction: Network pharmacology and experimental validation","authors":"Yilin Liu , Xinling Zhao , Qing Long , Zeyi Guo , Xiang Cao , Xiaoqin Wu , Fangjun Tu , Yunqiao Zhang , Xu You , Xiuying Shi , Zhaowei Teng , Yong Zeng","doi":"10.1016/j.eujim.2024.102380","DOIUrl":"https://doi.org/10.1016/j.eujim.2024.102380","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to identify the target of action of Wendan decoction, a classical Chinese herbal formula used for the treatment of psychiatric disorders, specifically schizophrenia, using network pharmacology.</p></div><div><h3>Methods</h3><p>Traditional Chinese Medicine (TCM) bioinformatics and network pharmacology were employed to predict the genes regulated by miR-26b-5p and identify the active ingredients and related targets of the Wendan decoction from public databases. Key components and targets were screened by constructing a \"TCM-component-target\" network, followed by pathway enrichment analysis of the related targets. The expression levels of miR-26b-5p and prostaglandin-endoperoxide synthase 2 (<em>PTGS2</em>) in the peripheral blood of patients with schizophrenia patients and healthy individuals were determined using RT-qPCR. Molecular docking was performed to explore the interaction between the active ingredients of the Wendan decoction and key differentially expressed molecules, investigating the role of miR-26b-5p in the treatment of schizophrenia with the Wendan decoction.</p></div><div><h3>Results</h3><p>A total of 135 active constituents were extracted from the Wendan decoction, and 144 molecules, including <em>PTGS2</em> and other derivatives, were screened for drug-target and disease-target inter-mapping. Compared to peripheral blood samples from healthy controls and patients with depression, peripheral blood samples from patients with schizophrenia patients showed low miR-26b-5p expression and elevated <em>PTGS2</em> expression, with no significant difference observed in the expression between healthy controls and patients with depression. Molecular docking revealed that several active compounds were found in five of the six constituents of the Wendan decoction bound with <em>PTGS2</em>. Pathway enrichment analysis suggested that the Wendan decoction may have a potential therapeutic role in treating schizophrenia by regulating the circadian rhythm, N-methyl-<span>d</span>-aspartate glutamate receptor activity, inflammatory mediator regulation of transient receptor potential channels, and other pathways implicated in schizophrenia.</p></div><div><h3>Conclusion</h3><p>Wendan decoction may treat schizophrenia via the miR-26b-5p targeting factor <em>PTGS2</em> and inflammation-related pathways. miR-26b-5p, combined with <em>PTSG2</em>, holds the potential as a differential diagnostic marker for schizophrenia.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102380"},"PeriodicalIF":1.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382024000507/pdfft?md5=6707e483381a1edde4202904de19904d&pid=1-s2.0-S1876382024000507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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