European Journal of Integrative Medicine最新文献

{"title":"Effectiveness of infantile tuina for improving motor dysfunction in children with spastic cerebral palsy: A systematic review and meta-analysis of randomized controlled trials","authors":"Zicheng Wei ,&nbsp;Zhen Liu ,&nbsp;Hongjiao Wu ,&nbsp;Kaizheng Wang ,&nbsp;Shuang Wu ,&nbsp;Lijiang Lv ,&nbsp;Zhizhen Lv","doi":"10.1016/j.eujim.2024.102382","DOIUrl":"10.1016/j.eujim.2024.102382","url":null,"abstract":"<div><h3>Introduction</h3><p>Infantile cerebral palsy (ICP) is a disease that causes cognitive and motor dysfunction in children, severely affecting their growth and mental health. Infantile tuina is a prominent treatment modality in traditional Chinese medicine (TCM). However, the effectiveness of infantile tuina remains uncertain. This systematic review aimed to assess the efficacy of infantile tuina in enhancing motor dysfunction in ICP through randomized controlled trials (RCTs).</p></div><div><h3>Methods</h3><p>We completed the meta-analysis according to the PRISMA 2020 checklist. Randomized controlled trials (RCTs) were searched for in seven databases including Medline, Ovid EMBASE, Cochrane Library, Web of Science, China national knowledge infrastructure, Chinese biomedical literature, and Wan Fang from the establishment of the database until November 7, 2023. The effectiveness of infantile tuina to treat motor dysfunction in children with spastic cerebral palsy was evaluated using outcome indexes such as effective rate, Gross motor function measure (GMFM), Modified Ashworth Scale (MAS), and ankle passive dorsiflexion angle.</p></div><div><h3>Results</h3><p>A total of 12 RCTs were included in this systematic review, which included 950 patients. Meta-analysis of the results indicated that infantile tuina combined with conventional rehabilitation treatment for ICP produced better results than conventional rehabilitation treatment alone. The experimental group intervention had a significant effect on the improvement of ICP treatment efficiency [Relative Risk (RR) = 1.21; 95% Confidence Interval (CI) = 1.10, 1.33], GMFM [MD = 4.76, 95% CI = 3.23, 3.29], MAS [Mean difference (MD) = -0.83, 95% CI = -1.02, -0.64], and ankle dorsiflexion angle [MD = -4.82, 95% CI = -7.45, -2.18]. The results were statistically significant (<em>P</em> &lt; 0.05).</p></div><div><h3>Conclusions</h3><p>As a complementary therapy to conventional rehabilitation therapy, infantile tuina produced significant improvements in ICP treatment effectiveness in this systematic review. The main limitation in the evidence was a lack of high-quality studies and many studies had small sample sizes.</p></div><div><h3>Registration</h3><p>PROSPERO ID: CRD42023446889.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102382"},"PeriodicalIF":1.9,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of miR-26b-5p and PTGS2 in schizophrenia treatment using Wendan decoction: Network pharmacology and experimental validation","authors":"Yilin Liu ,&nbsp;Xinling Zhao ,&nbsp;Qing Long ,&nbsp;Zeyi Guo ,&nbsp;Xiang Cao ,&nbsp;Xiaoqin Wu ,&nbsp;Fangjun Tu ,&nbsp;Yunqiao Zhang ,&nbsp;Xu You ,&nbsp;Xiuying Shi ,&nbsp;Zhaowei Teng ,&nbsp;Yong Zeng","doi":"10.1016/j.eujim.2024.102380","DOIUrl":"https://doi.org/10.1016/j.eujim.2024.102380","url":null,"abstract":"<div><h3>Introduction</h3><p>This study aimed to identify the target of action of Wendan decoction, a classical Chinese herbal formula used for the treatment of psychiatric disorders, specifically schizophrenia, using network pharmacology.</p></div><div><h3>Methods</h3><p>Traditional Chinese Medicine (TCM) bioinformatics and network pharmacology were employed to predict the genes regulated by miR-26b-5p and identify the active ingredients and related targets of the Wendan decoction from public databases. Key components and targets were screened by constructing a \"TCM-component-target\" network, followed by pathway enrichment analysis of the related targets. The expression levels of miR-26b-5p and prostaglandin-endoperoxide synthase 2 (<em>PTGS2</em>) in the peripheral blood of patients with schizophrenia patients and healthy individuals were determined using RT-qPCR. Molecular docking was performed to explore the interaction between the active ingredients of the Wendan decoction and key differentially expressed molecules, investigating the role of miR-26b-5p in the treatment of schizophrenia with the Wendan decoction.</p></div><div><h3>Results</h3><p>A total of 135 active constituents were extracted from the Wendan decoction, and 144 molecules, including <em>PTGS2</em> and other derivatives, were screened for drug-target and disease-target inter-mapping. Compared to peripheral blood samples from healthy controls and patients with depression, peripheral blood samples from patients with schizophrenia patients showed low miR-26b-5p expression and elevated <em>PTGS2</em> expression, with no significant difference observed in the expression between healthy controls and patients with depression. Molecular docking revealed that several active compounds were found in five of the six constituents of the Wendan decoction bound with <em>PTGS2</em>. Pathway enrichment analysis suggested that the Wendan decoction may have a potential therapeutic role in treating schizophrenia by regulating the circadian rhythm, N-methyl-<span>d</span>-aspartate glutamate receptor activity, inflammatory mediator regulation of transient receptor potential channels, and other pathways implicated in schizophrenia.</p></div><div><h3>Conclusion</h3><p>Wendan decoction may treat schizophrenia via the miR-26b-5p targeting factor <em>PTGS2</em> and inflammation-related pathways. miR-26b-5p, combined with <em>PTSG2</em>, holds the potential as a differential diagnostic marker for schizophrenia.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102380"},"PeriodicalIF":1.9,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382024000507/pdfft?md5=6707e483381a1edde4202904de19904d&pid=1-s2.0-S1876382024000507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the use of colored Trace Images in Kids' Books with passive distractions to decrease pain and fear during cannulation in children: A randomized clinical trial","authors":"Sherzad Khudeida Suleman ,&nbsp;Nizar BakirYahya ,&nbsp;Stefan Nilsson ,&nbsp;Karin Enskär","doi":"10.1016/j.eujim.2024.102379","DOIUrl":"https://doi.org/10.1016/j.eujim.2024.102379","url":null,"abstract":"<div><h3>Introduction</h3><p>Cannulation can be frightening and a source of pain and fear for pediatric patients. The study evaluated the effectiveness of Trace Image and Coloring for Kids-Book (TICK-B) as active distraction with two passive distractions in reducing children's pain and fear during cannulation.</p></div><div><h3>Methods</h3><p>This study employed a prospective, controlled, randomized experiment conducted from January 2023 to April 2023 at Heevi Pediatric hospital in the Kurdistan region of Iraq. A total of 176 participants were randomly assigned in to one of four study groups, with 44 participants assigned to each group. The interventions were administered 2–3 min before continued until the cannulation procedure finished. Data were collected through interviews conducted before and after the procedure. Children reported pain using Wong-Baker FACES® scale, and fear evaluated with the Child Fear Scale as an outcome after the cannulation procedure. Children's outcomes during and after procedure were measured 2–3 min after completed procedure.</p></div><div><h3>Results</h3><p>All distraction methods significantly reduced children's pain and fear compared to the control group. TICK-B showed large effects in reducing average pain (mean difference = -4.65, 95 % CI: -5.67 to -3.65) and fear (mean difference = -2.18, 95 % CI: -2.67 to -1.69) during cannulation. Post-procedure, TICK-B maintained large pain relief (mean difference = -4.10, 95 % CI: -4.98 to -3.22) and fear reduction (mean difference = -1.89, 95 % CI: -2.39 to -1.39) effects. Music listening and cartoon watching both showed improvements compared to the control group, with minimal differences between them in terms of pain and fear during the procedure. Also, the differences were the same after the procedure. No adverse events were reported.</p></div><div><h3>Conclusion</h3><p>All distraction techniques effectively and safely decreased children's pain and fear during cannulation. The TICK-B technique most effectively reduced children's pain and fear during cannulation procedures compared to music-listening and cartoon-watching techniques.</p></div><div><h3>Trial registration</h3><p>NCT04977323.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102379"},"PeriodicalIF":1.9,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382024000490/pdfft?md5=cfe245189763eea4e01a73c061bb2c99&pid=1-s2.0-S1876382024000490-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the reporting assessment of clinical trials with non-pharmacological therapies in Chinese medicine","authors":"Hanzhi Tan ,&nbsp;Nana Wang ,&nbsp;Han Li ,&nbsp;Chung Wah Cheng ,&nbsp;Yalin Jiao ,&nbsp;Dongni Shi ,&nbsp;Juan Wang ,&nbsp;Jiashuai Deng ,&nbsp;Ji Li ,&nbsp;Fei Han ,&nbsp;Ping Wang ,&nbsp;Zhaoxiang Bian ,&nbsp;Xuan Zhang","doi":"10.1016/j.eujim.2024.102381","DOIUrl":"https://doi.org/10.1016/j.eujim.2024.102381","url":null,"abstract":"<div><h3>Introduction</h3><p>Non-pharmacological treatment in Chinese Medicine (NPTCM) plays a crucial and distinct role in clinical practice, and increasingly within randomized controlled trials (RCTs). With the successive publication of Consolidated Standards Of Reporting Trials (CONSORT) extensions for acupuncture, moxibustion, cupping, and Tuina/massage, this study aims to assess the reporting characteristics and quality of published RCTs based on these specific reporting checklists.</p></div><div><h3>Methods</h3><p>Databases including All EBM Reviews, AMED, Embase, Ovid MEDLINE(R), CNKI, VIP Chinese Medical Journal Database, and Wanfang Data will be searched, with the publication date limited to January 1, 2022 to December 31, 2022. The interventions of interest are RCTs involving acupuncture, moxibustion, cupping or Tuina/massage, with language restricted to Chinese or English. Two reviewers will conduct the screening process with double-checking by the third reviewer. The purpose of data extraction is to summarize the study designs and implementation characteristics of these four types of interventions, and a pre-designed data extraction form will be utilized. For quality assessment, a standard operating procedure (SOP) will be developed, using an assessment form based on the checklist items of the four CONSORT extensions. Each article will be reviewed by two reviewers in a paired back-to-back manner, and Cohen's kappa statistic will be calculated to assess inter-rater agreement. Descriptive statistics will be used to present the quality of reporting. Subgroup comparisons will be conducted regarding different types of interventions, locations and publication languages.</p></div><div><h3>Discussion</h3><p>This study aims to identify and assess the current reporting characteristics and quality of the above four types of NPTCM interventional trials. Based on the results, it is hoped to provide suggestions for future application or promotion of the CONSORT extensions for NPTCM.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102381"},"PeriodicalIF":1.9,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382024000519/pdfft?md5=8866f83e65c4f29c875c6be8434107ea&pid=1-s2.0-S1876382024000519-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of acupuncture in the treatment of osteoporosis-related fractures: A systematic review and Bayesian network meta-analysis","authors":"Ruya Sheng ,&nbsp;Mingxia Wu ,&nbsp;Yali Qiu ,&nbsp;Qing Sun","doi":"10.1016/j.eujim.2024.102378","DOIUrl":"https://doi.org/10.1016/j.eujim.2024.102378","url":null,"abstract":"<div><h3>Introduction</h3><p>In recent years, there has been an increasing interest in the utilization of different acupuncture regimens as alternative therapies for fractures linked to osteoporosis. Nevertheless, the efficacy of these diverse treatment choices continues to be a subject of contention. To tackle this matter, a comprehensive Bayesian network meta-analysis has been undertaken to thoroughly assess the potential advantages of various acupuncture techniques in the management of osteoporosis-related fractures.</p></div><div><h3>Methods</h3><p>Until April 12, 2023, an extensive search was carried out to identify randomized controlled trials investigating the application of acupuncture in the treatment of fractures related to osteoporosis. The search encompassed multiple databases, such as PubMed, EMBASE, Web of Science, Cochrane Library, China Knowledge Network (CNKI), WanFang, VIP Database, and SinoMed. The network meta-analysis specifically aimed to evaluate the efficacy of different acupuncture techniques in conjunction with conservative biomedical treatment or invasive biomedical surgical treatment for managing fractures related to osteoporosis.</p></div><div><h3>Results</h3><p>A total of 35 articles were included, involving 2,727 patients. These articles examined and investigated five different types of acupuncture treatment options. The evaluated acupuncture treatments included ordinary acupuncture, electroacupuncture, floating acupuncture, needle-knife, and warm acupuncture. Results showed that when electroacupuncture was combined with daily care, it resulted in a significant decrease in both the Visual Analogue Scale (VAS) score and the Oswestry Disability Index (ODI) score. Specifically, the VAS score decreased by -2.29 (95 % CI: -3.84 ∼ -0.75), while the ODI score decreased by -22.03 (95 % CI: -33.88 ∼ -10.54) compared to those who received only daily care. Additionally, there was a significant decrease in the VAS score when comparing the combination of ordinary acupuncture with percutaneous vertebroplasty (PVP) surgery to PVP surgery alone. The VAS score decreased by -1.39 (95 % CI: -2.73 ∼ -0.04) in the group that underwent both acupuncture and surgery. Similarly, in the comparison between warm acupuncture combined with percutaneous kyphoplasty (PKP) surgery and PKP surgery alone, there was a significant reduction in the VAS score. The VAS score decreased by -3.62 (95 % CI: -5.49 ∼ -1.74) in the group that received both acupuncture and surgery.</p></div><div><h3>Conclusions</h3><p>The implementation of a well-balanced acupuncture treatment regimen can effectively alleviate pain and disability experienced by patients with fractures related to osteoporosis, irrespective of whether surgical intervention is conducted.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102378"},"PeriodicalIF":1.9,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupoint prescriptions, treatment protocol and outcome evidence for acupuncture in diabetic peripheral neuropathy: A scoping review of clinical studies","authors":"Shiqi Ma ,&nbsp;Haipeng Huang ,&nbsp;Fuyu Xue ,&nbsp;Qi Wang ,&nbsp;Shuo Yu ,&nbsp;Qingyu Hou ,&nbsp;Mengyuan Li ,&nbsp;Hongfeng Wang","doi":"10.1016/j.eujim.2024.102376","DOIUrl":"10.1016/j.eujim.2024.102376","url":null,"abstract":"<div><h3>Introduction</h3><p>Acupuncture is a complementary therapy for diabetic peripheral neuropathy (DPN). This scoping review systematically collect clinical studies using acupuncture for the treatment of DPN to analyze and summarize acupuncture point prescriptions, treatment protocols, and outcome indicators regarding clinical trials of acupuncture for DPN. The results will help guide the selection of future clinical protocols.</p></div><div><h3>Methods</h3><p>Eight databases were searched from their inception to March 1, 2023, including PubMed, Excerpt Medica Database (EMBASE), Web of Science, Cochrane Library, Google Scholar, China National Knowledge Infrastructure (CNKI), China Biology Medicine disk (CBM disk), Wan Fang, and Chinese Scientific Journal Database (VIP). Demographic characteristics of study participants, patients, treatment details, acupuncture prescriptions, and outcome indicators were screened and extracted.</p></div><div><h3>Results</h3><p>A total of 219 clinical studies were included, and the number of published studies showed a year-on-year increase. Two hundred eleven studies (96.34%) were conducted in China. One hundred fifty one (68.95%) were conducted in Traditional Chinese Medicine (TCM) hospitals. Two hundred and six (94.06%) studies were randomized controlled trials (RCTs) that treated patients with different clinical symptoms of DPN in 17,945 patients. The primary intervention was manual acupuncture treatment, most commonly with stainless steel needles (φ0.35 mm × 40 mm) left in place for more than 30 minutes. Acupuncture points SP6 and ST36 combined were applied most frequently, and the five points with frequencies over 100 were ST36, SP6, LI11, LI4, and GB34. The outcome indicators of acupuncture for DPN were mainly nerve conduction velocity, effectiveness rating scale, and efficiency. Adverse events were reported in only a few studies and mainly included nausea, pain, and diarrhea.</p></div><div><h3>Conclusions</h3><p>This review provides evidence on treatment protocols, point prescriptions, and outcome metrics for acupuncture for DPN. However, the low quality of the study designs included in the clinical literature resulted in a degree of selection bias in the findings, which still needs to be validated by high-quality clinical trials. Future studies should be designed as more rigorous multicenter, large-sample randomized controlled trials to improve the accuracy and consistency of the effectiveness evaluation of acupuncture for DPN and enrich the standardized clinical treatment protocols for DPN.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"70 ","pages":"Article 102376"},"PeriodicalIF":1.9,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142050204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical profiling and therapeutic potential of Baliospermum montanum: A promising inhibitor of COX-2/15-LOX enzymes and NO production in LPS-stimulated RAW 264.7 macrophages","authors":"Anithakumari Aswathy Krishna ,&nbsp;Beena Levakumar Abhirami ,&nbsp;Abdul Rahim Muhammed Jasim ,&nbsp;Sulochana Priya ,&nbsp;Alaganandam Kumaran","doi":"10.1016/j.eujim.2024.102377","DOIUrl":"10.1016/j.eujim.2024.102377","url":null,"abstract":"<div><h3>Introduction</h3><p><em>Baliospermum montanum</em> (BM) is traditionally used to treat various ailments such as inflammation, rheumatoid arthritis, pain, etc. The root part of BM is well documented for its anti-inflammatory activity. However, the present study evaluates the multitargeted anti-inflammatory activity of the less explored BM leaf part. This is the first study investigating the COX-2, 15-LOX dual inhibiting potential and NO production inhibition of BM leaf extracts, fractions and compounds.</p></div><div><h3>Methods</h3><p>The BM leaf's water, ethanol, and hydroethanolic extracts were evaluated for anti-inflammatory activity by assessing the inhibition of COX-2, 15-LOX, and NO production. Additionally, the antioxidant potential of the extracts was determined through DPPH, ABTS, and FRAP assays. The most active ethanol extract was fractionated into 12 fractions and tested for anti-inflammatory, antioxidant, phenol and flavonoid content. Compounds were isolated from the most active fractions and identified using NMR techniques. The isolated compounds were checked for their anti-inflammatory activity. In addition, HPLC analysis of ethanol extract, fractions, and isolated compounds was carried out.</p></div><div><h3>Results</h3><p>The ethanol extract exhibited higher inhibition of COX-2, 15-LOX enzymes and NO production (IC₅₀ 35.75 ± 1.95 μg/mL) in LPS-treated RAW 264.7 cells. It also showed higher antioxidant activity. Following the fractionation of the ethanol extract using different solvents, only the ethyl acetate fractions demonstrated inhibition of COX-2, 15-LOX enzymes, and NO production. The ethyl acetate and acetone fractions are excellent sources of antioxidants, phenolic and flavonoid compounds. An effort to find the active principles from these ethyl acetate fractions resulted in the isolation and identification of four potent anti-inflammatory agents, namely, (-)-epiafzelechin, afzelechin-(4α→8)-afzelechin, afzelechin-(4α→8)-epiafzelechin and β-sitosterol-<span>d</span>-glycoside. The first three compounds were reported for the first time from this plant and afzelechin-(4α→8)-afzelechin was found to be a potent inhibitor of the COX-2/15 LOX enzyme as well as NO production (IC₅₀ = 5.9 ± 1.09 µM).</p></div><div><h3>Conclusion</h3><p>Based on these findings, we conclude that ethanol extract, fractions, and isolated compounds exert anti-inflammatory activity through multiple therapeutic mechanisms. The present study scientifically supports the traditional use of plant BM for treating inflammation and other related disorders.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102377"},"PeriodicalIF":1.9,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141405494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Chinese herbal formula CDD-2103 for remission maintenance of ulcerative colitis: Study protocol for a randomized, double-blinded, placebo-controlled trial","authors":"Xuan Zhang ,&nbsp;Hor Yue Tan ,&nbsp;Wing Lam To ,&nbsp;Ziwan Ning ,&nbsp;Ka Wing Cheng ,&nbsp;Jialing Zhang ,&nbsp;Emily Au ,&nbsp;Keyi Zhou ,&nbsp;Hoi Ki Wong ,&nbsp;Heung Lam Mok ,&nbsp;Jiaruo Xu ,&nbsp;Matthew Koh ,&nbsp;Zhaoxiang Bian","doi":"10.1016/j.eujim.2024.102375","DOIUrl":"10.1016/j.eujim.2024.102375","url":null,"abstract":"<div><h3>Introduction</h3><p>Ulcerative colitis (UC) is a chronic lifelong disorder and a prominent subtype of inflammatory bowel disease (IBD) globally. Studies have indicated that Chinese herbal medicines (CHM) may offer advantages in alleviating the clinical symptoms experienced by UC patients. CDD (Centre for Chinese Herbal Medicine Drug Development)-2103 is a CHM formula for maintenance of UC remission. We aim to evaluate its efficacy and safety in remission patients with a traditional Chinese medicine (TCM) pattern of spleen deficiency with dampness obstruction (SDDO).</p></div><div><h3>Methods</h3><p>This study is a multi-center, randomized, double-blind, placebo-controlled clinical trial. A total of 82 eligible patients will be randomized to receive either CDD-2103 or placebo for 24 weeks, followed by post-treatment monitoring at week 36 and 48. The primary outcome is the recurrence rate according to the modified Mayo Score at week 24. The secondary outcomes consist of Partial Mayo Score, Inflammatory bowel disease questionnaire (IBDQ), Simple clinical colitis activity index (SCAAI), TCM syndrome scale and safety assessment.</p></div><div><h3>Conclusion</h3><p>This study will provide evidence on the effectiveness and safety of CDD-2103 in reducing chance of clinical relapse for UC patients, and will further shed light on the UC remission maintenance with TCM.</p></div><div><h3>Trial registration</h3><p>Chinese Clinical Trial Registry, ChiCTR2100043200. Registered on 8 February 2021. <span>https://www.chictr.org.cn/showproj.html?proj=121,692</span><svg><path></path></svg>.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102375"},"PeriodicalIF":1.9,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1876382024000453/pdfft?md5=c0d787410cd1dd60ff45e10d5339e8af&pid=1-s2.0-S1876382024000453-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical exploration of botanical remedies used by traditional healers and herbalists for voice disorders","authors":"Hala Jarrar ,&nbsp;Mahmoud Alatrash ,&nbsp;Faten Amer","doi":"10.1016/j.eujim.2024.102374","DOIUrl":"10.1016/j.eujim.2024.102374","url":null,"abstract":"<div><h3>Background</h3><p>Traditional herbal medicine is an integral part of global healthcare, with a growing reliance on natural remedies. This study investigates herbal medicine practitioners' perspectives on plants used to treat voice disorders in Palestine.</p></div><div><h3>Methods</h3><p>A quantitative cross-sectional study was conducted in the West Bank of Palestine, involving 100 herbal medicine practitioners who completed a semi-structured questionnaire between March and June 2023. Information on herbs was collected, including their Arabic names, parts used, and preparation methods. Plant samples were preserved and identified at the pharmacognosy lab at An-Najah National University. Quantitative analysis employed fidelity level, use-value, and choice value to assess cultural and ecological aspects.</p></div><div><h3>Results</h3><p>The herbalists recommended 20 herbs. The top five herbs identified were <em>Anthemis cotula, Pimpinella anisum, Zingiber officinale, Clinopodium serpyllifolium</em>, and <em>Mentha spicata</em>, with fidelity levels ranging from 76 % to 96 %. Leaves and fruits were the most commonly utilized plant parts, with the Lamiaceae and Apiaceae families being the most frequent.</p></div><div><h3>Conclusion</h3><p>Folkloric herbal medicine contributes to community healthcare and drug development. This study documents 20 indigenous Palestinian phyto-remedies that enhance vocal health, highlighting rich traditional knowledge. Collaboration between traditional healers and healthcare professionals can offer informed recommendations, while educational programs bridge traditional and contemporary healthcare. This pioneering research provides valuable insights globally, being the first to explore herbalists' indigenous knowledge of voice disorder remedies. While focusing on the West Bank, its implications extend worldwide, guiding future research into herbal remedies for voice disorders.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"69 ","pages":"Article 102374"},"PeriodicalIF":1.9,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and implementation of an evidence-based biofield therapy standardized documentation tool","authors":"Paul Guillory ,&nbsp;Tanecia Blue ,&nbsp;John Casken ,&nbsp;Courtnee Nunokawa","doi":"10.1016/j.eujim.2024.102369","DOIUrl":"10.1016/j.eujim.2024.102369","url":null,"abstract":"<div><h3>Introduction</h3><p>Biofield therapy (BT) is a complementary health practice involving the use of subtle energy to promote healing; however, monitoring the quality of care after implementing a BT program can be particularly challenging. The aim of this project was to strategically design, implement, and evaluate an evidence-based BT documentation tool to capture relevant data elements to display in a quality metric dashboard, while also being satisfactory to the practitioners who use it.</p></div><div><h3>Methods</h3><p>Utilizing the Consolidated Framework for Implementation Research (CFIR) method, key stakeholders at a government healthcare facility were gathered to design and use a structured documentation tool. After the tool's deployment, the stakeholders were routinely assessed over a three-month period to evaluate its effectiveness and identify areas for improvement. At the end of the period a practitioner satisfaction questionnaire was deployed and a quality metric dashboard was launched.</p></div><div><h3>Results</h3><p>Seven of the eleven BT-trained practitioners (64 %) used the template during the evaluation period and 255 sessions were documented. Forty-five percent of the staff responded to the Likert scored satisfaction questionnaire with 100 % indicating the template improved documentation, fit into the workflow, and facilitated interdisciplinary communication. The dashboard presented nine data elements, such as session indication and patient symptom scores, which can be filtered by date and location.</p></div><div><h3>Discussion</h3><p>The satisfaction scores validated findings from the literature relative to structured documentation, quality review, and program evaluation. These outcomes support the expansion of BT into different clinical settings, foster future BT research endeavors, and allow for BT to be included in broader medical data analytic efforts.</p></div><div><h3>Conclusion</h3><p>A structured documentation tool designed with findings from the evidence and input from key stakeholders can be an effective and satisfactory means of capturing quality metrics for evaluating the implementation of BT.</p></div>","PeriodicalId":11932,"journal":{"name":"European Journal of Integrative Medicine","volume":"68 ","pages":"Article 102369"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}