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Uterine Leiomyofibroma in the Gynecological Pathology of the Emergency County Clinical Hospital Saint Andrew the Apostle Constanta 子宫平滑肌纤维瘤在妇科病理急诊县临床医院圣安德鲁使徒康斯坦察
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0006
C. Tomescu, Ana-Maria Brezeanu, D. Brezeanu, A. Tomescu, Cadar Emin
Abstract Benign pelvic-abdominal tumor formations are an important part of female pelvic pathology. Uterine fibroids occupy an important place in gynecological benign pathology, among pelvic-abdominal tumors, A retrospective study was performed for a period of 5 years (2015-2019) on a number of 1505 patients admitted to the Clinical Emergency Hospital St. Andrew the Apostle Constanta, on the two departments of Obstetrics-Gynecology OG I and OG II. The patients were followed according to the following criteria: age, origin, symptoms, and the type of surgery performed.
盆腔-腹腔良性肿瘤形成是女性盆腔病理的重要组成部分。子宫肌瘤在妇科盆腹肿瘤中占有重要的良性病理地位。本文对康斯坦察圣安德鲁临床急诊医院(St. Andrew the Apostle Constanta)妇产科OG I和OG II两个科室1505例患者进行了为期5年(2015-2019)的回顾性研究。根据以下标准对患者进行随访:年龄、来源、症状和手术类型。
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引用次数: 0
Clinical Course and Treatment of Human Brucellosis in a Sample of Hospitalized Cases in Albania 阿尔巴尼亚住院病例中人类布鲁氏菌病的临床病程和治疗
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0007
Dritan Rami, A. Ylli, P. Pipero, E. Ramosaço, A. Harxhi
Abstract Brucellosis remains a public health problem in many Mediterranean countries. In this work are presenting data of human brucellosis clinics and treatment in a sample of hospitalized patients. Methods: All patient charts at regional hospital in Gjirokastra, Albania were systematically reviewed, during the period 2016-2021. All hospitalized patients with a laboratory confirmed diagnoses of brucellosis were included in the study. Variables of interest were clinical symptoms, clinical course and treatment provided. Sub-acute brucellosis was defined as clinical persistence of 3-12 months while cases with clinical symptoms persisting for ≥12 months were defined as chronic brucellosis. Results: 79% of the 86 patients were male and residing in rural areas. Fever, profuse sweating and arthralgia were the most common clinical signs. Around 70% of the brucellosis patients showed all these three symptoms. Despite a systematic tendency for more frequent presence of high fever, increased sweating and arthralgia on younger patients we could not find statistically significant differences among demographic categories. 18.6% of cases presented persistence of clinical signs after at least 3 months from the moment of the diagnoses. Almost 7% of the cases were classified as chronic cases. 75.6% of all patients were treated with a combination of doxycycline and ceftriaxone antibiotic regime. Conclusions: The massive use of a cephalosporin in treatment of brucellosis cannot be justified and may reflect a larger problem related to population awareness and health provider attitudes concerning antibiotic use in Albania. The results of this study may assist future interventions to improve brucellosis case management at hospitals or primary health care level as well as national measures at a larger scale for control of the disease.
布鲁氏菌病仍然是许多地中海国家的公共卫生问题。在这项工作中,提供了住院患者样本中人类布鲁氏菌病诊所和治疗的数据。方法:系统回顾2016-2021年期间阿尔巴尼亚吉罗卡斯特地区医院的所有患者病历。所有实验室确诊为布鲁氏菌病的住院患者均纳入研究。感兴趣的变量是临床症状、临床病程和所提供的治疗。亚急性布鲁氏菌病定义为临床持续3-12个月,而临床症状持续≥12个月定义为慢性布鲁氏菌病。结果:86例患者中79%为农村男性。发热、多汗和关节痛是最常见的临床症状。约70%的布鲁氏菌病患者表现出这三种症状。尽管年轻患者有更频繁出现高热、出汗增多和关节痛的系统性趋势,但我们没有发现人口统计类别之间的统计学显著差异。18.6%的病例在确诊后至少3个月仍有临床症状。近7%的病例被归类为慢性病例。75.6%的患者采用强力霉素和头孢曲松联合治疗方案。结论:在治疗布鲁氏菌病中大量使用头孢菌素是不合理的,这可能反映了阿尔巴尼亚人口对抗生素使用的认识和卫生服务提供者的态度存在更大的问题。这项研究的结果可能有助于未来的干预措施,以改善医院或初级卫生保健水平的布鲁氏菌病病例管理,以及在更大范围内控制该疾病的国家措施。
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引用次数: 0
Validation of a Spectrophotometric Method of Some Antidepressant Drugs 一些抗抑郁药物分光光度法的验证
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0001
Cadar Emin, S. Rodica, A. Ionescu, Anca M. Safta, C. Tomescu
Abstract Although the causes of depression include a wide range of conditions, from neurodegenerative to thyroid, they all have one common denominator, changes in the brain. Depression can be located in multiple brain regions simultaneously, which may be derived from a common molecular abnormality found in neurons in many brain regions. Abnormalities of receptors or impulse transmission could be the answer. In this work, a simple and accurate spectrophotometric method was developed for the analysis of escitalopram oxalate in various pharmaceutical formulations. In this method, absorbance was measured at 238 nm for escitalopram oxalate. Method validation parameters were studied. The method can be used for quality control of pharmaceutical forms containing escitalopram. Also, by the same method, the actual active substance concentrations compared to those listed on the package, the standard deviations and the relative standard deviations.
虽然抑郁症的病因包括从神经退行性疾病到甲状腺疾病等多种疾病,但它们都有一个共同点,那就是大脑的变化。抑郁症可以同时发生在多个大脑区域,这可能是由于在许多大脑区域的神经元中发现了一种共同的分子异常。受体异常或冲动传递可能是答案。本文建立了一种简便、准确的分光光度法分析各种制剂中草酸艾司西酞普兰的方法。在238 nm处测定了草酸艾司西酞普兰的吸光度。研究了方法验证参数。该方法可用于艾司西酞普兰制剂的质量控制。同时,用同样的方法,将实际活性物质浓度与包装上所列的浓度进行比较,得到标准偏差和相对标准偏差。
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引用次数: 1
Brown Seaweeds from Black Sea Coast as an Important Source of Bioactive Compounds of Interest for Human Health 黑海沿岸的褐藻是对人类健康有益的生物活性化合物的重要来源
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0010
A. Drăgan, R. Sîrbu, Emin Cadâr
Abstract For human nutrition, algae are important organisms that can offer essential compounds and new bioactive substances with pharmaceutical and medicinal value. Macroalgae contain nutritional elements such as lipids, proteins, vitamins and minerals and they are used as food supplements because they are known to be high in mineral content. There are a lot of nutritionally compunds that can be identified in algae such as polysaccharides, polyphenols, diterpenes, sterols, carbohydrates, peptides, polyunsaturated fatty acids, pigments and dietary fibers. Nutraceuticals are confirmed to be used as medicines because they are a good protector against chronic diseases and they have physiological benefits. Algae bioactive compounds could be used as an anticoagulant, antioxidant, anti-inflammatory, antibacterial, antimicrobial, antifungal, anticancer, antiviral, antidiabetic, antiobesity, antihypertensive and hypercholesterolemic nutraceuticals. Although only some of the algae have been studied properly for their chemical composition and properties, they are a considerable biological resource with ability for use as a raw material. In this paper the compounds from red and brown algae from the Romanian seaside are evaluated as sources of biologically active ingredients with benefits in human health.
藻类是人类营养中重要的生物,可以提供具有药用价值的必需化合物和新的生物活性物质。巨藻含有营养元素,如脂质、蛋白质、维生素和矿物质,它们被用作食品补充剂,因为它们富含矿物质。藻类中含有多种营养成分,如多糖、多酚、二萜、甾醇、碳水化合物、多肽、多不饱和脂肪酸、色素和膳食纤维等。营养保健品被证实可以作为药物使用,因为它们是预防慢性疾病的良好保护剂,并且具有生理上的益处。藻类生物活性化合物可作为抗凝血、抗氧化、抗炎、抗菌、抗菌、抗真菌、抗癌、抗病毒、抗糖尿病、抗肥胖、降高血压和高胆固醇的营养品。虽然目前只有部分藻类的化学成分和性质得到了充分的研究,但它们是一种相当可观的生物资源,具有作为原料的能力。本文评价了罗马尼亚海边的红藻和褐藻中含有的有益人体健康的生物活性成分。
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引用次数: 0
Plastic Pollution in Albania: Survey on Citizen’s Perceptions and Attitudes 阿尔巴尼亚的塑料污染:公民的看法和态度调查
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0004
Ani Bajrami, F. Osmani, Elvisa Sokoli
Abstract Plastics are polymers synthesized from petrochemicals or from biomass raw materials. In recent decades, worldwide plastics production has increased exponentially. An estimated 8.3 billion tons of plastic have been produced worldwide resulting in an estimated 6.3 billion tons of plastic waste disposed in landfill or discarded into the natural environment. Plastic is widely used: is inexpensive, durable, resource efficient and easily attainable. The article makes some preliminary observations based on questionnaire data distributed through probability stratified random sampling method between November 2021 and July 2022. The data provides some useful insights into citizens perceptions and attitudes about plastic pollution. Majority of respondents agree on the fact that plastic pollution is harmful to the environment (94%). Additionally, 77.1% of respondents agree both on the fact that nature conservation activities are necessary and successful if community or citizens are involved. Strategies which can be used to reduce plastic pollution need to provide further incentives for public participation. An example is using citizen science, to address and mitigate plastic pollution both at local and national level.
摘要塑料是由石油化工产品或生物质原料合成的聚合物。近几十年来,全球塑料产量呈指数级增长。据估计,全世界生产了83亿吨塑料,导致约63亿吨塑料废物被填埋或丢弃到自然环境中。塑料被广泛使用:廉价、耐用、资源高效且容易获得。本文根据2021年11月至2022年7月期间采用概率分层随机抽样方法分发的问卷数据进行了初步观察。这些数据为了解公民对塑料污染的看法和态度提供了一些有用的见解。大多数受访者(94%)认为塑料污染对环境有害。此外,77.1%的受访者同意,如果社区或市民参与,自然保育活动是必要和成功的。可用于减少塑料污染的战略需要为公众参与提供进一步的激励。一个例子是利用公民科学来解决和减轻地方和国家层面的塑料污染。
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引用次数: 0
Therapeutical Properties of Bioactive Compounds Extracted from Ganoderma lucidum Species on Acute and Chronic Diseases 灵芝生物活性成分对急慢性疾病的治疗作用
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0008
Carolina Pascale, R. Sîrbu, Emin Cadâr
Abstract Ganoderma lucidum or Reishi is a medicinal mushroom of significant importance that is being used for the prevention and treatment of various diseases, due to its numerous pharmacological and therapeutic properties. The Ganodermataceae family is diverse, but the focus is on the lucidum species because of its specific biologically active macromolecules such as polysaccharides, triterpenoids, steroids, phenolic compounds, lactones, and fatty acids that were isolated from the mycelia and fruiting bodies. Ganoderma lucidum species have many benefits over the immune system (promoting health) and properties such as: anti-tumoral, anti-inflammatory, anti-allergic, anti-viral, anti-bacterial and antioxidant. Based on the literature, triterpenoids and polysaccharides are the most abundant active compounds that possess anti-diabetic, hepatoprotective, cytotoxic and anti-hypertensive effects. A review of the literature showed that there are very few papers that studied semisolid dosage forms preparations based of Ganoderma lucidum extract to have been used on damaged skin and skin diseases, neither have there been enough studies on its anti-aging properties.
灵芝(Ganoderma lucidum)或灵芝(Reishi)是一种具有重要意义的药用蘑菇,由于其众多的药理和治疗特性,正被用于预防和治疗各种疾病。灵芝科植物种类繁多,但由于其从菌丝体和子实体中分离出的多糖、三萜、甾体、酚类化合物、内酯和脂肪酸等具有特殊生物活性的大分子,故重点关注灵芝属植物。灵芝种类对免疫系统有许多好处(促进健康)和特性,如:抗肿瘤,抗炎,抗过敏,抗病毒,抗菌和抗氧化。据文献报道,三萜和多糖是最丰富的具有抗糖尿病、保肝、细胞毒和降压作用的活性化合物。查阅文献发现,以灵芝提取物为基础的半固体剂型制剂用于损伤皮肤和皮肤病的研究文献很少,对其抗衰老性能的研究也很少。
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引用次数: 1
Mandatory COVID-19 Vaccination and Free Self-Determination in the Health Field in Italy 意大利卫生领域的强制性COVID-19疫苗接种和自由自决
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0002
Emanuela Furramani
Abstract The COVID-19 pandemic and the issues related to health emergency management have raised concerns about fundamental rights protection. One of the most complex and contentious issues in doctrine and jurisprudence is the introduction of mandatory COVID-19 vaccination for specified categories of subjects, such as healthcare workers and individuals of a specific age range, as occurred in Italy. The debate in Italy over the mandatory COVID-19 vaccination requirement focuses on whether this obligation interferes with the individual’s fundamental right to free self-determination as guaranteed by Article 32 of the Italian Constitution. In jurisprudence and doctrine, conflicting opinions are noted concerning this topic. Part of the doctrine argue that mandatory COVID-19 vaccination compromises some fundamental rights guaranteed by the Italian Constitution, such as the right to free self-determination and respect for human dignity. Other opinions find the basis of the vaccination in the community’s best interests, citing Article 32 of the Italian Constitution, which allows for the imposition of compulsory health treatment to safeguard citizens’ health. In this regard, the issue of mandatory COVID-19 vaccination requires a reflection on the balance of two fundamental rights: the individual right to free self-determination and the community’s interest in terms of protecting public health.
新冠肺炎疫情及卫生应急管理相关问题引发了人们对基本权利保护的关注。理论和法理中最复杂和最具争议的问题之一是对特定类别的主体(如卫生保健工作者和特定年龄范围的个人)实施强制性COVID-19疫苗接种,如意大利所发生的情况。意大利国内关于COVID-19强制性疫苗接种要求的辩论重点是,这一义务是否干扰了《意大利宪法》第32条保障的个人自由自决权的基本权利。在法理学和理论中,关于这一主题的意见是相互矛盾的。该学说的部分内容认为,强制性COVID-19疫苗接种损害了意大利宪法保障的一些基本权利,如自由自决权和尊重人类尊严的权利。其他意见认为,接种疫苗的基础符合社区的最大利益,并援引《意大利宪法》第32条,该条允许实施强制性保健治疗,以保障公民的健康。在这方面,强制性COVID-19疫苗接种问题需要反思两项基本权利的平衡:个人自由自决权和社区在保护公共健康方面的利益。
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引用次数: 0
Evaluation of Gait in Albanian β-thalassemia Patients 阿尔巴尼亚β-地中海贫血患者步态评价
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0003
G. Pano
Abstract One of the most prevalent genetic diseases in the world is beta thalassemia. Hemoglobin synthesis is decreased by the blood condition beta thalassemia. Patients with thalassemia exhibit a range of bone problems, including as spinal deformities, osteopenia and osteoporosis, as well as growth failure. This study’s main goal was to evaluate gait and balance in Albanian β-thalassemia patients. In this study, 18 participants aged 17 to 29 years old (5 males and 13 females) from three distinct epidemiological cities in Albania took part. Gait analysis was performed using “T&T medilogic medizintechnik gmbh” wi-fi insoles. “General Gait Parameters”, results of the “Effective Foot Length, left [%]” parameter mean results [67.59%], reveals approx a 2% difference compared with the relative normative mean [69.7%]. Also, “Effective Foot Length, left [%]” mean results [65.49%], reveals approximately a 3.5% difference compared with the relative normative mean [69.7%]. “General Gait Parameters”, data comparisons revealed statistically significant differences between “is” and “nom.” measurements for the following variables: “Rel Double Step Length”, “Double Step Duration”, “Effective Foot Length Right” and “Width Of Gait Right” (p<0.005). Results for the rest of the variables shwed a not statistically significant difference. The aim of the study was to assess the gait parameter in Albanian individuals with thalassemia. Based on the result of the “General Gait Parameters”, data reveal a difference in the % of the average gait line which is related to effective distribution in the insole length showing a specific indication of insecure gait. According to the findings, gait issues are a significant health issue for beta thalassemia patients which are most likely caused by disease-related side-effects such high calcium levels after blood transfusions, inactivity caused by insufficient muscle mass, and all other health-related disease conditions. It is advised that the gait analysis exam to be included in their regular health check-ups. Future studies should be conducted involving larger ß-thalassemia patients take into account the unique state of this category to better evaluate the gait problems related with general static and dynamic posture problems. Clinicians’ health specialists and rehabilitation experts when planning B-Thal rehabilitation programs sholud use gait analysis exam as a regular health check-up.
地中海贫血是世界上最普遍的遗传性疾病之一。血红蛋白合成因地中海贫血而减少。地中海贫血患者表现出一系列骨骼问题,包括脊柱畸形、骨质减少和骨质疏松以及生长衰竭。本研究的主要目的是评估阿尔巴尼亚β-地中海贫血患者的步态和平衡。在这项研究中,来自阿尔巴尼亚三个不同流行病学城市的18名年龄在17至29岁之间的参与者(5名男性和13名女性)参加了研究。使用“T&T mediilogic medizintechnik gmbh”wi-fi鞋垫进行步态分析。“一般步态参数”,“有效脚长,左[%]”参数平均结果[67.59%],与相对规范平均值[69.7%]相比,显示出约2%的差异。此外,“有效脚长,左[%]”均值结果[65.49%]与相对规范均值[69.7%]相比,显示出约3.5%的差异。“一般步态参数”,数据比较显示,“is”和“nom”测量的“Rel双步长”、“双步持续时间”、“有效脚长右”和“步态右宽度”的变量差异有统计学意义(p<0.005)。其余变量的结果没有统计学上的显著差异。该研究的目的是评估阿尔巴尼亚地中海贫血患者的步态参数。根据“一般步态参数”的结果,数据显示平均步态线的百分比存在差异,这与鞋垫长度的有效分布有关,显示了步态不安全的特定指示。根据研究结果,步态问题是地中海贫血患者的一个重要健康问题,这很可能是由疾病相关的副作用引起的,如输血后高钙水平、肌肉量不足引起的不活动,以及所有其他与健康相关的疾病。建议将步态分析检查纳入定期健康检查。未来的研究应涉及更大的ß-地中海贫血患者,考虑到这类患者的独特状态,以更好地评估与一般静态和动态姿势问题相关的步态问题。临床医生的健康专家和康复专家在规划B-Thal康复项目时,应将步态分析检查作为常规健康检查。
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引用次数: 0
Determinants of Patient Satisfaction with Health Care: A Literature Review 病患健康照护满意度之决定因素:文献回顾
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0005
Rezarta Kalaja
Abstract This research paper aims to explore the field of patient satisfaction in health care, by performing a literature review on existing healthcare articles that analyse determinants of patient’s satisfaction and theories on patient satisfaction assessment. Patient satisfaction is one of the most important factors to determine the success of health care providers. Determining the exact definition, determinants and characteristics of patients that influence satisfaction, as well as different theories on satisfaction, are highly discussed elements in the literature for a long period of time. The research instrument was a literature review by combining different view from many researchers. The literature was searched in databases such as Emerald, Medline/PubMed, Web of Science, ScienceDirect, Scopus. Patient satisfaction appears to play an important role in evaluation of service quality. From the literature review, it was observed that the main determinants of patient satisfaction were the demographic characteristics, expectations and experiences of the patients. Communication is also an extremely important element that affects patient satisfaction. Other research should be conducted to delve even more into this very important area of health care.
摘要:本研究旨在通过对现有医疗保健文章进行文献综述,分析患者满意度的决定因素和患者满意度评估的理论,探讨医疗保健领域的患者满意度。患者满意度是决定医疗服务提供者成功与否的最重要因素之一。确定影响满意度的患者的确切定义、决定因素和特征,以及关于满意度的不同理论,是长期以来文献中高度讨论的因素。研究方法是结合众多研究者的不同观点进行文献综述。在Emerald、Medline/PubMed、Web of Science、ScienceDirect、Scopus等数据库中检索文献。患者满意度在服务质量评价中起着重要的作用。从文献综述中,我们观察到患者满意度的主要决定因素是患者的人口统计学特征、期望和经历。沟通也是影响患者满意度的一个极其重要的因素。应该进行其他研究,以更深入地研究这一非常重要的卫生保健领域。
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引用次数: 0
Biomedical Applications Based on Marine Collagen Obtained from the Jellyfish Species Rhizostoma Pulmo Extracted from the Black Sea 从黑海海蜇中提取的海洋胶原蛋白在生物医学上的应用
Pub Date : 2023-04-01 DOI: 10.2478/ejnsm-2023-0009
Ana-Maria Pesterau, R. Sîrbu, Emin Cadâr
Abstract Due to its unique properties, collagen is used in various emerging fields such as the pharmaceutical and biomedical device industries, as well as in related fields: nutraceuticals, cosmetics, food, beverages and nutritional supplements. Marine gelatin, one of the biomaterials involved in food and medicinal research, is denatured collagen produced from acid, alkaline, or enzyme hydrolysis. Gelatin is a crucial ingredient for the food, pharmaceutical, medical, biomedical focusing on versatile applications. Jellyfish collagen is a valuable resource for bioplastics and biomaterials used in various health sectors. Recently, marine organisms have been considered viable sources of collagen because they do not harbor transmissible diseases. In particular, fish biomass, as well as the catches of other types of organisms, such as small fish, jellyfish, starfish, sea urchins, sponges, possess a significant content of collagen. The collagen extracted from the species Rhizostoma pulmo from the Black Sea basin is also part of the bioresources that can be used to obtain natural marine collagen from this type of invertebrates. The use of discarded or hither to unused biomass could contribute to the development of a sustainable collagen extraction process with a positive impact on the ecosystem. In the future it is desired to approach a world strategy that minimizes the amount of waste and that supports all three general objectives of sustainability: sustainable economic well-being, social well-being and environmental protection.
由于其独特的性能,胶原蛋白被应用于各种新兴领域,如制药和生物医学器械行业,以及相关领域:保健品、化妆品、食品、饮料和营养补充剂。海洋明胶是一种用于食品和医药研究的生物材料,是由酸、碱或酶水解产生的变性胶原蛋白。明胶是食品、制药、医疗、生物医学的关键成分,具有多种用途。水母胶原蛋白是用于各种卫生部门的生物塑料和生物材料的宝贵资源。最近,海洋生物被认为是胶原蛋白的可行来源,因为它们不携带传染性疾病。特别是鱼类生物量,以及其他类型的生物,如小鱼、水母、海星、海胆、海绵,都含有大量的胶原蛋白。从黑海盆地的根瘤菌(Rhizostoma pulmo)中提取的胶原蛋白也是生物资源的一部分,可用于从这种无脊椎动物中获取天然海洋胶原蛋白。利用废弃或未使用的生物质可以促进可持续胶原蛋白提取过程的发展,对生态系统产生积极影响。今后希望采取一种世界战略,尽量减少废物的数量,并支持可持续性的所有三个一般目标:可持续的经济福利、社会福利和环境保护。
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引用次数: 0
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