Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00014
I. Russo, J. Russo
The relevance of this work lies in the possibility of extrapolating conclusions drawn here to the human situation, since we have assessed the validity of the rat model for the study of breast cancer in women through comparative studies in these two species (Russo and Russo, 1988). The novelty of our studies is the evidence that hCG protects the mammary gland against carcinogenic initiation and progression, mimicking the physiological process of pregnancy, without crippling other reproductive or endocrine functions (Russo et al, 1990d; Russo and Russo, 1992). The importance of both differentiation and cell proliferation in tumour initiation and progression, which we have stressed in previous publications (Russo and Russo, 1980, 1987, 1988; Russo et al, 1982) validates the use of these end-points for assessing the effect of hormones under the influence of hCG on the mammary gland initiated in the process of carcinogenesis. Collectively, our results provide solid bases for developing physiological means of breast cancer prevention and control.
这项工作的相关性在于有可能将这里得出的结论外推到人类的情况，因为我们已经通过对这两个物种的比较研究评估了大鼠模型在女性乳腺癌研究中的有效性(Russo和Russo, 1988)。我们研究的新颖之处在于，有证据表明，hCG可以保护乳腺免受致癌的发生和发展，模仿怀孕的生理过程，而不会损害其他生殖或内分泌功能(Russo等人，1990;Russo and Russo, 1992)。分化和细胞增殖在肿瘤发生和发展中的重要性，我们在以前的出版物中强调过(Russo和Russo, 1980,1987, 1988;Russo et al, 1982)验证了使用这些终点来评估激素在hCG影响下对癌变过程中启动的乳腺的影响。总之，我们的研究结果为发展乳腺癌的生理预防和控制手段提供了坚实的基础。
{"title":"Physiological bases of breast cancer prevention.","authors":"I. Russo, J. Russo","doi":"10.1097/00008469-199311000-00014","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00014","url":null,"abstract":"The relevance of this work lies in the possibility of extrapolating conclusions drawn here to the human situation, since we have assessed the validity of the rat model for the study of breast cancer in women through comparative studies in these two species (Russo and Russo, 1988). The novelty of our studies is the evidence that hCG protects the mammary gland against carcinogenic initiation and progression, mimicking the physiological process of pregnancy, without crippling other reproductive or endocrine functions (Russo et al, 1990d; Russo and Russo, 1992). The importance of both differentiation and cell proliferation in tumour initiation and progression, which we have stressed in previous publications (Russo and Russo, 1980, 1987, 1988; Russo et al, 1982) validates the use of these end-points for assessing the effect of hormones under the influence of hCG on the mammary gland initiated in the process of carcinogenesis. Collectively, our results provide solid bases for developing physiological means of breast cancer prevention and control.","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85726744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00012
J. Taylor‐Papadimitriou, B. D'souza, F. Berdichevsky, M. Shearer, S. Martignone, D. Alford
{"title":"Human models for studying malignant progression in breast cancer.","authors":"J. Taylor‐Papadimitriou, B. D'souza, F. Berdichevsky, M. Shearer, S. Martignone, D. Alford","doi":"10.1097/00008469-199311000-00012","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00012","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91026547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00020
W. Jäger
{"title":"The early detection of disseminated (metastasized) breast cancer by serial tumour marker measurements.","authors":"W. Jäger","doi":"10.1097/00008469-199311000-00020","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00020","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79189880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-11-01DOI: 10.1097/00008469-199311000-00015
M. Gerber
{"title":"Benign breast diseases: risk factor or precancerous state?","authors":"M. Gerber","doi":"10.1097/00008469-199311000-00015","DOIUrl":"https://doi.org/10.1097/00008469-199311000-00015","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85236095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-06-01DOI: 10.1097/00008469-199306000-00009
A. Tuyns
{"title":"Oesophageal cancer: prospects for primary prevention.","authors":"A. Tuyns","doi":"10.1097/00008469-199306000-00009","DOIUrl":"https://doi.org/10.1097/00008469-199306000-00009","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72619856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-06-01DOI: 10.1097/00008469-199306000-00017
J. Faivre, M. Boutron, F. Doyon, M. Pignatelli, O. Kronborg, A. Giacosa, H. de Oliveira, E. Benito, C. O'Morain
{"title":"The ECP calcium fibre polyp prevention study preliminary report. ECP Colon Group.","authors":"J. Faivre, M. Boutron, F. Doyon, M. Pignatelli, O. Kronborg, A. Giacosa, H. de Oliveira, E. Benito, C. O'Morain","doi":"10.1097/00008469-199306000-00017","DOIUrl":"https://doi.org/10.1097/00008469-199306000-00017","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87488429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-05-01DOI: 10.1097/00008469-199305000-00001
G. Ferrara, L. Santi
{"title":"Molecular oncology: from basic research towards clinical application.","authors":"G. Ferrara, L. Santi","doi":"10.1097/00008469-199305000-00001","DOIUrl":"https://doi.org/10.1097/00008469-199305000-00001","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79130064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-05-01DOI: 10.1097/00008469-199305000-00010
L. Döbrössy
In recent years, the countries of central and eastern Europe, the Baltic States, and the newly-independent countries (established in place of the former Soviet Union), have experienced a much heavier burden of cancer as compared to other subregions of Europe. This appears to be the result of a decline in the standard of health care services, environmental neglect and the high prevalence of health-damaging behaviour, smoking in particular. Their anti-cancer potential falls short of their needs. The existing and still widening gap between what are considered best and worst patterns, practices and prospects in cancer control in Europe has posed a challenge to both the World Health Organization (WHO) and the international cancer community. On WHOs initiative, a group of major European cancer organizations is determined to use their considerable potential, both moral and scientific, in supporting national efforts in all possible ways in those countries that need progress. Recently, WHO has initiated an all-European alliance with the intention of narrowing the gap between what are regarded as best and worst patterns, practices and prospects in cancer control in Europe.
{"title":"WHO initiative: cancer prevention in Europe.","authors":"L. Döbrössy","doi":"10.1097/00008469-199305000-00010","DOIUrl":"https://doi.org/10.1097/00008469-199305000-00010","url":null,"abstract":"In recent years, the countries of central and eastern Europe, the Baltic States, and the newly-independent countries (established in place of the former Soviet Union), have experienced a much heavier burden of cancer as compared to other subregions of Europe. This appears to be the result of a decline in the standard of health care services, environmental neglect and the high prevalence of health-damaging behaviour, smoking in particular. Their anti-cancer potential falls short of their needs. The existing and still widening gap between what are considered best and worst patterns, practices and prospects in cancer control in Europe has posed a challenge to both the World Health Organization (WHO) and the international cancer community. On WHOs initiative, a group of major European cancer organizations is determined to use their considerable potential, both moral and scientific, in supporting national efforts in all possible ways in those countries that need progress. Recently, WHO has initiated an all-European alliance with the intention of narrowing the gap between what are regarded as best and worst patterns, practices and prospects in cancer control in Europe.","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81539383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-05-01DOI: 10.1097/00008469-199305000-00012
P. Mainguet, A. Jouret
{"title":"Colon cancer prevention: role of the endoscopy. Review of the new histopathological techniques.","authors":"P. Mainguet, A. Jouret","doi":"10.1097/00008469-199305000-00012","DOIUrl":"https://doi.org/10.1097/00008469-199305000-00012","url":null,"abstract":"","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80086534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1993-05-01DOI: 10.1097/00008469-199305000-00011
G. Ziant
The methodology for an information campaign is discussed, detailing follow up in five stages: (1) assessment of needs: a good knowledge of behaviour patterns and the kind of information needed is the basic element to create the concept of a campaign. A pre-survey is an indispensable tool to secure this information; (2) basic scientific information: communication to the public has to be based on precise and recent scientific data; (3) comprehension of the information: communicating with the general public should be through texts that are clear and accessible to the greater part of the population; (4) production of supporting documents: each element of the campaign has to produce an impact on the person receiving the message; and (5) evaluating the impact of an information campaign. An evaluation can check whether objectives have been reached, and also correct errors and help prepare the next campaign even more professionally. These five stages are essential to set up a successful information campaign. We also give examples from our magazines Cancer-info and Smoke Buster-info. Through information public opinion can be mobilized to influence political decisions in the public health sector. One evidence for the importance of collective influence on political decision makers is our campaign to promote the total ban on tobacco advertising. As large-scale information campaigns need important financial resources it is essential to balance the cost to generate sufficient funds to finance further projects in the health sector; we discuss this matter as well as the impact on the image of the association.(ABSTRACT TRUNCATED AT 250 WORDS)
{"title":"Public information: a major tool in cancer prevention.","authors":"G. Ziant","doi":"10.1097/00008469-199305000-00011","DOIUrl":"https://doi.org/10.1097/00008469-199305000-00011","url":null,"abstract":"The methodology for an information campaign is discussed, detailing follow up in five stages: (1) assessment of needs: a good knowledge of behaviour patterns and the kind of information needed is the basic element to create the concept of a campaign. A pre-survey is an indispensable tool to secure this information; (2) basic scientific information: communication to the public has to be based on precise and recent scientific data; (3) comprehension of the information: communicating with the general public should be through texts that are clear and accessible to the greater part of the population; (4) production of supporting documents: each element of the campaign has to produce an impact on the person receiving the message; and (5) evaluating the impact of an information campaign. An evaluation can check whether objectives have been reached, and also correct errors and help prepare the next campaign even more professionally. These five stages are essential to set up a successful information campaign. We also give examples from our magazines Cancer-info and Smoke Buster-info. Through information public opinion can be mobilized to influence political decisions in the public health sector. One evidence for the importance of collective influence on political decision makers is our campaign to promote the total ban on tobacco advertising. As large-scale information campaigns need important financial resources it is essential to balance the cost to generate sufficient funds to finance further projects in the health sector; we discuss this matter as well as the impact on the image of the association.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":11950,"journal":{"name":"European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1993-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84107331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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