European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"Prediction of survival in fetuses with left-sided congenital diaphragmatic hernia: Which method is better using MRI observed to expected total fetal lung volumes?","authors":"Romain Corroenne ,&nbsp;Leticia Benitez Quintanilla ,&nbsp;Luis Delgadillo Chabolla ,&nbsp;Ahmed A. Nassr ,&nbsp;Roopali Donepudi ,&nbsp;Alice King ,&nbsp;Rebecca M. Johnson ,&nbsp;Pamela Ketwaroo ,&nbsp;Amy R. Mehollin-Ray ,&nbsp;Jessian L. Munoz ,&nbsp;Michael Belfort ,&nbsp;Magdalena Sanz Cortes","doi":"10.1016/j.ejogrb.2025.02.032","DOIUrl":"10.1016/j.ejogrb.2025.02.032","url":null,"abstract":"<div><h3>Objective</h3><div>The Observed to Expected Total Fetal Lung Volume (O/E-TFLV) ratio, calculated using fetal MRI, is a common method to assess pulmonary hypoplasia severity in congenital diaphragmatic hernia (CDH). However, its accuracy may be affected by uncertain gestational age (GA), inaccurate pregnancy dating, or abnormal fetal growth. This study aimed to evaluate whether GA determined by first-trimester dating or fetal size at imaging affects the ability of O/E-TFLV to predict 6-month survival in fetuses with isolated left-sided CDH.</div></div><div><h3>Methods</h3><div>Retrospective cohort study of fetuses with isolated left-sided CDH. O/E-TFLV was calculated using GA based on CRL (O/E-TFLV_GA) or fetal size-determined GA (O/E-TFLV_EFW) at the time of MRI. Prediction of survival was evaluated using ROC curves and logistic regression analyses adjusting by CDH severity and liver herniation.</div></div><div><h3>Results</h3><div>Ninety-seven fetuses underwent third-trimester MRI, with seventy-nine (81 %) also having second-trimester MRI. At six months, 80/97 (82.5 %) were alive. No significant differences were observed between O/E-TFLV_GA and O/E-TFLV_EFW during the second (31.5[2–74]% vs. 31.7[2.5–86]%, p = 0.71) or third trimester (33.6[0.1–134.3]% vs. 31.7[8–105]%, p = 0.55). Higher O/E-TFLV_GA and higher O/E-TFLV_EFW were associated with higher chances of survival (Second trimester: O/E-TFLV_GA: Odds Ratio 1.09 [95 %CI: 1.02–1.20], p = 0.04; O/E-TFLV_EFW: 1.10[1.01–1.20], p = 0.04; Third trimester: O/E-TFLV_GA: 1.06[1.02–1.16], p = 0.04; O/E-TFLV_EFW: 1.03[1.01–1.09], p = 0.04). No significant differences were found in predictive accuracy between O/E-TFLV_GA and O/E-TFLV_EFW based on Area Under the Curve (AUC) analysis (Second trimester: p = 0.65; Third trimester: p = 0.72).</div></div><div><h3>Conclusion</h3><div>There were no difference in the prediction of survival in isolated left-sided CDH fetuses using O/E-TFLV regardless of the method used to calculate O/E-TFLV.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 241-246"},"PeriodicalIF":2.1,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"sCEACAM-1 levels in maternal blood in case of threatened preterm birth","authors":"Bora Zaimi ,&nbsp;Maria Victoria Bazzano ,&nbsp;Maximilian Rauh ,&nbsp;Maria Emilia Solano ,&nbsp;Maurice Kappelmeyer ,&nbsp;Angela Köninger","doi":"10.1016/j.ejogrb.2025.02.025","DOIUrl":"10.1016/j.ejogrb.2025.02.025","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to investigate the role of CEACAM1 in preterm birth. Preterm birth is a phenomenon with numerous triggers, with the immune system hypothesized to play a significant role in the process, aligning with the concept of ’birth as an immunological rejection phenomenon’. There are several approaches to predict preterm birth, and the determination of sCEACAM1 levels, a member of the carcinoembryonic antigen family, may serve as a potential candidate biomarker.</div></div><div><h3>Methods</h3><div>A single-center prospective case series study included 67 pregnant women aged 18 years or older who presented before 37 weeks of gestation with signs of preterm birth in the years 2021–2023. At the time of admission, CEACAM1 was determined in maternal blood.</div></div><div><h3>Results</h3><div>The median sCEACAM1 levels were significantly higher in women who delivered preterm compared to those who delivered at term respectively, 5014 pg/ml (IQR: 3592–8826) vs. 3353 pg/ml (IQR: 2354–5049) (p = 0.016).</div><div>The median sCEACAM1 level in the group with PPROM (premature preterm rupture of membranes) at 34 weeks’ gestation was 7001 pg/ml (IQR: 5683–13509), while the median sCEACAM1 level in the group without PPROM at 34 weeks’ gestation was 3884 pg/ml (IQR; 2461–4985) (p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>Pregnant women with preterm birth and/or PPROM before 34 weeks’ gestation have higher CEACAM1 levels compared to women with threatened preterm labor who finally had labot at term. The results suggest early activated immune system as a potential pathomechanism of preterm delivery.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 230-235"},"PeriodicalIF":2.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of body mass index on surgical outcomes in patients undergoing laparoscopic sacrohysteropexy and sacrocolpopexy","authors":"Ehud Grinstein ,&nbsp;Ohad Gluck ,&nbsp;Zdenek Rusavy ,&nbsp;Shimon Ginath ,&nbsp;Bruno Deval","doi":"10.1016/j.ejogrb.2025.02.031","DOIUrl":"10.1016/j.ejogrb.2025.02.031","url":null,"abstract":"<div><h3>Introduction</h3><div>Laparoscopic promontofixation is often considered the preferred approach for the treatment of significant apical pelvic organ prolapse (POP). Obesity is an established risk factor for pelvic organ prolapse (POP), and obese patients may constitute a substantial portion of those seeking care for uterovaginal prolapse. Our aim was to evaluate the impact of body mass index on perioperative complications and long-term outcomes of this procedure.</div></div><div><h3>Methods</h3><div>This is a single center retrospective cohort study. All patients who underwent laparoscopic sacrohysteropexy/sacrocolpopexy, between July 2011 and December 2021 were evaluated. The study population was divided into three groups, according to Body mass index (BMI) at time of surgery.</div></div><div><h3>Results</h3><div>Altogether 246 patients were included: 145 in group 1 (mean BMI 21.9 ± 2), 88 patients in group 2 (mean BMI 27.1 ± 1), and 13 patients in group 3 (mean BMI 33.0 ± 3). LSH was more frequent than LSC in all groups. The overall perioperative complications rate was 6.3 %. There were no differences in operative details and rates of perioperative complications between the groups. During follow-up period, 30 patients (12.2 %) presented with prolapse recurrence (objective and/or subjective). The rates of prolapse recurrence, as well as long-term complications, were similar between the groups. Similarly, the groups did not differ in postoperative functional results except for postoperative constipation (group 1––14.5 %, group 2––23.8 %, group 3––25 %, p = 0.001).</div></div><div><h3>Conclusion</h3><div>Laparoscopic sacrohysteropexy/sacrocolpopexy is associated with low rates of perioperative and long- term complications. We did not find a difference in rates of complications and/ or long-term outcomes, between different weights groups.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"308 ","pages":"Pages 29-33"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening on distress in fertility treatment (SCREENIVF): A systematic review","authors":"Aspasia Markopoulou ,&nbsp;Natalia Papadimitriou ,&nbsp;Zoi Tsimtsiou ,&nbsp;Dimitrios G. Goulis ,&nbsp;Anna-Bettina Haidich","doi":"10.1016/j.ejogrb.2025.02.029","DOIUrl":"10.1016/j.ejogrb.2025.02.029","url":null,"abstract":"<div><h3>Objective</h3><div>In recent years, several questionnaires have been developed to assess the quality of life of patients involved in assisted reproductive treatments, the degree of patient engagement and the outcome of assisted reproductive efforts. This review aimed to evaluate the psychometric properties of the SCREENIVF questionnaire.</div></div><div><h3>Methods</h3><div>Studies were searched in PubMed, Google Scholar, <span><span>Epistemonikos.org</span><svg><path></path></svg></span>, and PROSPERO up to July 2024. The search resulted in 66 studies, eight of which were eligible to be included in the systematic review. COSMIN guidelines were used for methodological quality assessment of studies and measurement property evaluation. The strength of evidence was rated according to the GRADE approach.</div></div><div><h3>Results</h3><div>SCREENIVF was categorized as stage A for “internal consistency” (Cronbach’s &gt;0.7), “structural validity”, “discriminant” and “convergent” validity. Reliability was categorized as stage A in couples [ICC (Intraclass Correlation Coefficient) &gt;0.7], while its use exclusively in women is contraindicated. Concerning “cross-cultural validity” and “criterion validity”, it was categorized as stage B and is recommended for use when no stage A questionnaires are available. Cross-cultural validity was deemed questionable as none of the studies performed Differential Item Functioning Analyses [DIF].</div></div><div><h3>Conclusion</h3><div>This systematic review highlights the importance of adopting standardized procedures for assessing the psychometric properties of questionnaires used in assisted reproduction.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 203-210"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal diagnosis and genetic counseling of a paternally inherited chromosome 8q24.22q24.23 microdeletion in a Chinese family","authors":"Min Xia ,&nbsp;Xin Wen ,&nbsp;Xuna Bian ,&nbsp;Lin Zhan ,&nbsp;Xu Liu","doi":"10.1016/j.ejogrb.2025.02.030","DOIUrl":"10.1016/j.ejogrb.2025.02.030","url":null,"abstract":"<div><h3>Background</h3><div>Copy number variants (CNVs) are an important source of normal and pathogenic genome variations. Especially CNVs identified in prenatal cases need careful considerations and correct interpretation if those are harmless or harmful variants from the norm. The literature on 8q24.22q24.23 microdeletion is rare, which is a challenge for genetic counselling.</div></div><div><h3>Case presentation</h3><div>We have performed prenatal diagnosis and genetic counseling of a paternally inherited 8q24.22q24.23 microdeletion. In this family, father with normal phenotype and fetus with abnormal phenotype have the same microdeletion.</div></div><div><h3>Conclusion</h3><div>Chromosomal microdeletions and microduplications are difficult to detect by conventional cytogenetics, combination of prenatal ultrasound, karyotype analysis, copy number variation sequencing (CNV-seq), whole-exome sequencing (WES) and genetic counseling is helpful for the prenatal diagnosis of chromosomal microdeletions/microduplications.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 211-213"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe hyperandrogenism secondary to a testosterone-secreting ovarian tumour in a patient with PCOS.","authors":"Samantha Taylor, Xing Zeng, Gabriel Levin","doi":"10.1016/j.ejogrb.2025.02.021","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2025.02.021","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and psychometric analysis of the Spanish version of the menstrual attitude questionnaire","authors":"Natalia Hernández-Segura ,&nbsp;Tania Fernández-Villa ,&nbsp;Raquel Leirós-Rodríguez ,&nbsp;Óscar Rodríguez-Nogueira","doi":"10.1016/j.ejogrb.2025.02.023","DOIUrl":"10.1016/j.ejogrb.2025.02.023","url":null,"abstract":"<div><h3>Problem</h3><div>In Spanish, there is no instrument available to assess the symptoms associated with the menstrual cycle.</div></div><div><h3>Background</h3><div>The evaluation of menstrual attitudes is clinically important, particularly for women who experience discomfort or pain during their menstrual cycle.</div></div><div><h3>Aim</h3><div>To validate and analyse the psychometric properties of the Menstrual Attitude Questionnaire (MAQ) in a Spanish population.</div></div><div><h3>Methods</h3><div>Adaptation and translation of the MAQ into Spanish, and cross-validation with data collected between March 2023 and March 2024 from 800 women (age 18–57 years).</div></div><div><h3>Findings</h3><div>The first factor analysis showed that six items did not load on any factor, so they were excluded from the analysis (Items 9, 17, 18, 24, 28 and 29). Once these items had been eliminated, the exploratory factor analysis showed that four factors could be extracted: performance, positivity, anticipation and subjectivity.</div></div><div><h3>Discussion</h3><div>Statistical analysis revealed that the proposed Spanish version of the MAQ consists of four factors. This implies a reduction of one factor compared with the original MAQ, resulting from the merging of two sections: ’Menstruation as an annoying event’ and ’Menstruation as a natural event’. Both components of the questionnaire refer to the ’identity’ or meaning that women attribute to their menstruation.</div></div><div><h3>Conclusions</h3><div>The Spanish version of the MAQ consists of four factors and 29 items, explaining most of the variability in the data. The Spanish version of the MAQ demonstrates good internal consistency and, therefore, represents a valuable tool for healthcare professionals who work daily with women with menstrual symptoms.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 214-219"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of giant placental chorioangioma causing polyhydramnios and fetal hydrops: A case report and literature review","authors":"Jia-Yue Wang ,&nbsp;Jian-Jiao Chen","doi":"10.1016/j.ejogrb.2025.02.024","DOIUrl":"10.1016/j.ejogrb.2025.02.024","url":null,"abstract":"<div><h3>Background</h3><div>Placental chorioangioma is a benign tumour of the placenta. In most cases, chorioangiomas are small and do not result in maternal or fetal complications. This report presents a case with a large placental chorioangioma, which was associated with an intrapartum event leading to significant maternal and perinatal morbidity.</div></div><div><h3>Case presentation</h3><div>A case of placental chorioangioma was diagnosed at 29 + 1 weeks of gestation. As the tumour enlarged progressively with polyhydramnios, further ultrasound examination indicated signs of fetal hydrops. Following multi-disciplinary team discussion, caesarean section was performed with delivery of a female infant. Pathological examination of the placenta confirmed an infarcted chorioangioma.</div></div><div><h3>Conclusions</h3><div>Placental chorioangiomas are benign, non-trophoblastic vascular neoplasms. While often asymptomatic, they can occasionally have unfavourable outcomes. Ultrasound examination plays a critical role in their diagnosis and monitoring. These neoplasms exhibit a wide range of clinical manifestations, leading to their classification as a spectrum of symptoms rather than a distinct syndrome. Early diagnosis, vigilant prenatal surveillance, and timely intervention are essential to minimize fetal morbidity and mortality.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 220-222"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Betamethasone dosing interval at 12 or 24 h apart: A systematic review and meta-analysis","authors":"Mohammed R. Said ,&nbsp;Fabrizio Zullo ,&nbsp;Moti Gulersen ,&nbsp;Vincenzo Berghella","doi":"10.1016/j.ejogrb.2025.02.017","DOIUrl":"10.1016/j.ejogrb.2025.02.017","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the effectiveness of administering 24 mg of betamethasone in two doses (12 mg each) at 12-hour versus 24-hour intervals in patients at risk of preterm delivery.</div></div><div><h3>Data sources</h3><div>A search was conducted in Ovid, Embase, Cochrane Central Register of Controlled Trials, <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span>, CINAHL, Scopus, and Google Scholar up to February 22, 2023. Search terms included “Betamethasone,” “Preterm delivery,” “Respiratory distress,” “Dosing interval,” and related keywords. No language or geographic restrictions were applied.</div></div><div><h3>Study eligibility criteria</h3><div>Randomized controlled trials of pregnant women at risk for preterm delivery between 23 and 34 weeks of gestation, randomized to receive 24 mg of betamethasone in two doses, either 12 or 24 h apart.</div></div><div><h3>Study appraisal and synthesis methods</h3><div>The primary outcome was the incidence of respiratory distress syndrome, with secondary outcomes including adverse maternal and neonatal events. Summary measures were reported as relative risk with 95% confidence intervals.</div></div><div><h3>Results</h3><div>Two randomized controlled trials (429 patients) were included. The rate of RDS was lower in the 12-hour dosing group (34.3 % vs. 45.7 %; RR 0.76, 95 % CI 0.46–1.25), but the difference was not statistically significant. Significant reductions in NICU admissions, surfactant use, and an increase in birthweight were observed in the 12-hour group. No significant differences were found for perinatal mortality, neonatal sepsis, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, chorioamnionitis, or maternal fever &gt; 100°F.</div></div><div><h3>Conclusions</h3><div>The 12-hour betamethasone dosing regimen showed benefits in reducing NICU admissions and surfactant use. Further studies are needed to confirm its advantages for other outcomes.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 164-169"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between low basal serum total testosterone levels and the risk of recurrent pregnancy loss in women with infertility","authors":"Yang Zhao ,&nbsp;Fengyi He ,&nbsp;Ping Pan ,&nbsp;Wenming Xu ,&nbsp;Huiyu Xu ,&nbsp;Dongzi Yang ,&nbsp;Xiaomiao Zhao","doi":"10.1016/j.ejogrb.2025.02.018","DOIUrl":"10.1016/j.ejogrb.2025.02.018","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the association between low basal total testosterone (TT) levels and the risk of recurrent pregnancy loss (RPL) in women with infertility.</div></div><div><h3>Design</h3><div>The study included women under 40 years with infertility, normal ovarian reserve, and regular ovulation. Participants were categorized into two groups: those with a history of recurrent pregnancy loss (RPL group) and those without a history of miscarriage (control group). All participants underwent in vitro fertilization (IVF) treatment. Serum TT and other sex hormone levels were measured on day 2 of spontaneous menstrual cycles and subsequently evaluated. Endocrine and coagulation conditions were also assessed.</div></div><div><h3>Results</h3><div>A total of 561 women were enrolled, into either the RPL group (n = 364) or the control group (n = 197) between January 2012 and December 2020. The RPL group demonstrated significantly lower median TT levels and were older compared with the control group (1.21 vs. 1.37 nmol/L, <em>P</em> = 0.001; 34 vs. 33 years, <em>P</em> = 0.010). Additionally, fasting plasma insulin levels were higher in the RPL group (10.67 vs. 8.84 mU/L, <em>P</em> &lt; 0.001). A negative correlation between basal TT levels and pregnancy loss frequency was observed. Low basal TT levels were significantly associated with RPL (OR: 1.58, 95 % CI: 1.04 – 2.41), with TT cut-off value of &lt;1.33 nmol/L indicating an increased likelihood of RPL (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Low basal serum TT levels are associated with an increased risk of RPL. However, further studies are required to evaluate the predictive value of basal TT levels in RPL risk.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"307 ","pages":"Pages 191-196"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}