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Trustworthiness criteria for meta-analyses of randomized controlled studies: OBGYN journal guidelines
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.08.043
OBGYN Editors’ Integrity Group OGEIG
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引用次数: 0
Efficacy and safety of oral versus vaginal misoprostol for medical management of first trimester missed abortion: A systematic review and meta-analysis 口服米索前列醇与阴道用米索前列醇治疗头三个月流产的有效性和安全性:系统回顾和荟萃分析。
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.015
Kanwal Majeed, Hina Syed, Muzna Murtaza, Zainab Muhammad Hanif, Hassam Ali

Background

Missed abortion in the first trimester is characterized by the cessation of embryonic or fetal development while the cervix remains closed, often resulting in little to no bleeding. Ultrasound examinations typically reveal an empty gestational sac or an embryo/fetus that lacks cardiac activity. Misoprostol is the primary medication used to manage early pregnancy loss.

Objectives

To compare the efficacy of misoprostol, orally and vaginally in management of first trimester missed abortion.“

Study Selection

This systematic review included randomised control trials of patients with a confirmed diagnosis with first-trimester missed abortion, comparing oral and vaginal misoprostol for uterine evacuation success, induction-expulsion time, patient satisfaction and adverse events.

Data Extraction and Analysis

Ten studies were included in this meta-analysis. All of them are RCTs with a number of patients 1,142 [578 in oral misoprostol group and 564 in vaginal misoprostol group]. Independent data extraction and quality assessment ensured unbiased results. We estimated risk ratios (RR) with 95% CIs using random-effects meta-analysis and evaluated quality of the included studies using Cochrane’s Risk of Bias tool (RoB 2).

Results

We included 10 studies in our analysis and for our primary outcome, vaginal misoprostol had a higher success rate, [RR: 0.85, P = 0.004], shorter induction-expulsion interval [MD:4.95, P = 0.0001], and greater patient satisfaction compared to oral administration [RR:0.85, P = 0.01]. Secondary outcomes revealed significantly higher nausea and vomiting in the oral group, with no significant difference in headache, dizziness, diarrhea, fever, excessive bleeding, or discharge. Severe crampy pain was also significantly higher in the oral group.

Conclusion

Our comprehensive review and meta-analysis indicate that the vaginal route of misoprostol is the most effective method for managing first-trimester missed abortions. This route achieves a significantly higher success rate and shorter induction- to-expulsion interval, along with greater patient satisfaction during follow-up sessions and fewer side effects.
背景:妊娠前三个月的漏报流产的特点是胚胎或胎儿发育停止,而子宫颈仍然闭合,通常导致很少或没有出血。超声检查通常显示妊娠囊空或胚胎/胎儿缺乏心脏活动。米索前列醇是治疗早期妊娠流产的主要药物。目的:比较口服米索前列醇和阴道米索前列醇治疗妊娠早期漏产的疗效。研究选择:本系统综述纳入了确诊为早期妊娠漏产的患者的随机对照试验,比较口服和阴道米索前列醇在子宫排出成功率、诱导排出时间、患者满意度和不良事件方面的差异。资料提取与分析:本meta分析共纳入10项研究。均为随机对照试验,患者数1142例[口服米索前列醇组578例,阴道米索前列醇组564例]。独立的数据提取和质量评估确保了公正的结果。我们使用随机效应荟萃分析估计95% ci的风险比(RR),并使用Cochrane的风险偏倚工具(RoB 2)评估纳入研究的质量。结果:我们在分析中纳入了10项研究,对于我们的主要结局,阴道米索前列醇具有更高的成功率,[RR:0.85, P = 0.004],更短的诱导-排出间隔[MD:4.95, P = 0.0001],与口服给药相比,患者满意度更高[RR:0.85, P = 0.01]。次要结果显示,口服组恶心和呕吐明显增加,头痛、头晕、腹泻、发热、大出血或分泌物无显著差异。严重的痉挛性疼痛在口腔组也明显更高。结论:我们的综合综述和荟萃分析表明,阴道途径米索前列醇是治疗早期妊娠流产最有效的方法。该方法的成功率明显较高,诱导至排出间隔较短,随访期间患者满意度较高,副作用较少。
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引用次数: 0
Prenatal diagnosis of vasa praevia in routine clinical practice: Prevention of stillbirths and impact on perinatal outcomes 常规临床实践中前置血管的产前诊断:预防死产及其对围产儿结局的影响。
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.016
Weiyu Zhang , Tara Giacchino , Harriet Hickey , Yehia Ghanem , Ranjit Akolekar

Background

Vasa praevia (VP) is defined as the presence of unsupported fetal blood vessels in close proximity of the internal os of the cervix. There is robust evidence from observational cohort studies and meta-analysis that prenatal diagnosis of VP is associated with excellent perinatal outcomes. We have previously proposed a two-stage strategy for prenatal diagnosis that can be implemented in routine clinical practice leading to effective prenatal diagnosis and prevention of fetal and neonatal mortality and morbidity.

Objectives

To demonstrate the feasibility and effectiveness of a two-stage screening strategy for prenatal diagnosis of VP in routine clinical practice and to estimate the potential impact on prevention of stillbirths and perinatal deaths.

Study design

This was an observational retrospective cohort study carried out at the Medway Fetal and Maternal Medicine Centre between January 2010 and June 2022. We examined the feasibility and effectiveness of this policy in terms of identification of a high-risk cohort and prenatal diagnosis of VP through routine 11–13 and 20–22 weeks’ ultrasound assessments based on the two-stage protocol. We also examined the impact on maternal, neonatal and perinatal outcomes in pregnancies with a confirmed diagnosis of VP. Absolute risks (95 %) were calculated based on rates of events in the two groups. Logistic regression analysis was used to estimate independent contribution from maternal and pregnancy characteristics in prediction of VP.

Results

The study population of 53,648 singleton pregnancies included 45 pregnancies with VP (0.83 per 1,000 pregnancies or an incidence of 1 in 1,192 pregnancies). VP was suspected in 56 cases and were resolved in 11 cases (19.6 %), thus leaving 45 pregnancies with a confirmed diagnosis of VP. The main findings that predicted VP included a low-lying placenta at 20–22 weeks’, placenta praevia, bilobed placenta and a velamentous cord insertion. In our study population, pregnancies with a prenatal diagnosis of VP had a livebirth rate of 100 % and an intact perinatal survival rate of 97.8 %.

Conclusion

Our study demonstrates that effective prenatal diagnosis of pregnancies with VP can be achieved in routine clinical practice with good perinatal outcomes.
背景:前置血管(VP)被定义为在宫颈内os附近存在无支撑的胎儿血管。来自观察性队列研究和荟萃分析的有力证据表明,VP的产前诊断与良好的围产期结局相关。我们之前提出了一个两阶段的产前诊断策略,可以在常规临床实践中实施,导致有效的产前诊断和预防胎儿和新生儿死亡率和发病率。目的:在常规临床实践中证明两阶段筛查策略用于VP产前诊断的可行性和有效性,并估计对预防死产和围产期死亡的潜在影响。研究设计:这是一项观察性回顾性队列研究,于2010年1月至2022年6月在Medway胎儿和孕产妇医学中心进行。我们通过基于两阶段方案的常规11-13周和20-22周超声评估,在确定高危队列和产前VP诊断方面检验了该政策的可行性和有效性。我们还研究了确诊VP的妊娠对孕产妇、新生儿和围产期结局的影响。绝对风险(95%)是根据两组事件发生率计算的。采用Logistic回归分析估计产妇和妊娠特征在预测VP中的独立贡献。结果:53,648例单胎妊娠的研究人群包括45例VP妊娠(每1,000例妊娠0.83例或1192例妊娠发生率1例)。56例怀疑VP, 11例(19.6%)痊愈,45例妊娠确诊VP。预测VP的主要发现包括20-22周时的低位胎盘、前置胎盘、双叶胎盘和膜状脐带插入。在我们的研究人群中,产前诊断为VP的孕妇的活产率为100%,完整的围产期存活率为97.8%。结论:我们的研究表明,在常规临床实践中,可以有效地对VP妊娠进行产前诊断,并获得良好的围产儿结局。
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引用次数: 0
Effects of phloroglucinol on uterine peristalsis after frozen embryo transfer in patients experiencing recurrent implantation failure: A retrospective case-control study 间苯三酚对反复植入失败患者冷冻胚胎移植后子宫蠕动的影响:一项回顾性病例对照研究。
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.026
Wei-wei Ma, Ting-ting Li, Jing Li

Objective

To retrospectively investigate the efficacy of phloroglucinol administration after freeze-thawed embryo transfer in patients experiencing recurrent implantation failure (RIF).

Materials and Methods

A total of 139 infertile couples who experienced RIF undergoing in vitro fertilisation and embryo transfer were divided into the control (n = 66) and the phloroglucinol (n = 73) groups. Women in the phloroglucinol group received 80 mg phloroglucinol 30 min after transfer, then once daily up to day 3 after the embryo transfer. Those in the control group did not receive phloroglucinol.

Results

Administration of phloroglucinol was associated with significantly higher rates of positive pregnancy tests [52.1 % versus (vs) 30.3 %], clinical pregnancy (45.2 % vs 27.3 %), and live births (38.4 % vs 21.2 %) compared with the control group (p < 0.05). Notably, patients with uterine peristalsis exceeding 3 waves/min exhibited significant improvement in positive pregnancy tests (67.6 % vs 38.5 %), implantation (50 % vs 24.6 %), and clinical pregnancy rates (58.8 % vs 33.3 %) following phloroglucinol intervention (p < 0.05).

Conclusion

Results suggested that the administration of phloroglucinol after frozen embryo transfer may improve pregnancy outcomes in patients who experienced RIF, primarily in those with uterine peristalsis >3 waves/min.
目的:回顾性探讨冻融胚胎移植后间苯三酚对复发性胚胎植入失败(RIF)患者的疗效。材料与方法:139对经历RIF并进行体外受精和胚胎移植的不育夫妇分为对照组(n = 66)和间苯三酚组(n = 73)。间苯三酚组的妇女在胚胎移植后30分钟接受80毫克间苯三酚,然后每天一次,直到胚胎移植后第3天。对照组不使用间苯三酚。结果:与对照组相比,间苯三酚组妊娠试验阳性率(52.1% vs 30.3%)、临床妊娠率(45.2% vs 27.3%)和活产率(38.4% vs 21.2%)显著升高(p)。结论:结果表明,冷冻胚胎移植后给予间苯三酚可改善RIF患者的妊娠结局,主要是那些有子宫肠膨出3波/分钟的患者。
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引用次数: 0
AI in obstetrics: Evaluating residents’ capabilities and interaction strategies with ChatGPT: Correspondence 产科人工智能:评估住院医师使用 ChatGPT 的能力和互动策略:通讯。
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.006
Benoit de la Fourniere, Pierre-François Ceccaldi, Mikhail Dziadzko, David Desseauve
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引用次数: 0
Serial intrapartum ultrasound to predict vaginal delivery using angle of progression and head- progression distance in term nulliparous women 连续产时超声预测阴道分娩的角度进展和头进展距离足月无产妇女。
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.014
Rajvi Hans, Deepa Reddy , Jyothi Shetty

Introduction

Over the past decade, intrapartum ultrasound (ITU) has been in the global limelight for labour monitoring. The use of the same in clinical settings of low- and middle-income countries (LMIC’s) however, is limited. Till date, angle of progression (AOP) stands as the most studied parameter. Very few studies, most from developed countries, have shown that other ITU measurements could also hold relevance to labour and delivery. In recent times, serial ITU has also garnered some attention and could possibly be a better predictor of labour outcome.

Aims

This study aimed to compare the predictive accuracies of AOP and head PD for vaginal delivery and to investigate whether the rate of change of serially measured AOP and head PD in the first stage is predictive of vaginal delivery.

Methods

A prospective observational study was conducted on 90 nulliparous women between April 2023 and July 2024 at a tertiary teaching hospital in South India. Participants had singleton pregnancies in cephalic presentation between 37–40 weeks with regular contractions, and cervical dilation ≥ 3 cm. Exclusion criteria included prior LSCS and abnormal cardiotocography. Intrapartum ultrasound was performed twice, once at recruitment and 3–5 h apart, to measure AOP and PD. Statistical analysis included ROC curve plotting for diagnostic accuracy of AOP and PD in predicting vaginal delivery.

Results

Of the 90 participants, 71 (78.9 %) delivered vaginally and 19 (21.1 %) had caesarean sections. AOP ≥ 120° and PD ≥ 2.7 cm at ≥ 6 cm cervical dilation showed a strong correlation with vaginal delivery, with sensitivity and specificity of 70.4 % and 94.7 %, and 63.4 % and 89.5 % respectively. Change (delta) in AOP > 10° had the highest diagnostic accuracy (81 %), with a positive predictive value of 92.2 %.

Conclusion

ITU offers valuable insights into labour progression. AOP and PD, particularly at cervical dilation of ≥ 6 cm, are predictive of vaginal delivery. Delta AOP serves as the most accurate predictor. Incorporating ITU into routine labour management enhances clinical decision-making, helping reduce unnecessary interventions and caesarean deliveries.
导言:在过去的十年中,产程超声(ITU)已成为全球关注的焦点。然而,在低收入和中等收入国家(LMIC's)的临床环境中,同样的使用是有限的。迄今为止,进度角(AOP)是研究最多的参数。很少有研究(大多数来自发达国家)表明,国际电联的其他衡量标准也可能与劳动和分娩有关。近年来,连续电联也引起了一些关注,可能是对劳动结果的更好预测。目的:本研究旨在比较AOP和头部PD对阴道分娩的预测准确性,并探讨在第一阶段连续测量AOP和头部PD的变化率是否可以预测阴道分娩。方法:对印度南部一家三级教学医院2023年4月至2024年7月期间90名未分娩妇女进行前瞻性观察研究。37-40周头位单胎妊娠,宫缩规律,宫颈扩张≥3cm。排除标准包括既往LSCS和异常心脏造影。产时超声检查2次,分别在复产时和间隔3-5 h检查AOP和PD。统计学分析采用ROC曲线绘制AOP和PD预测阴道分娩的诊断准确性。结果:在90名参与者中,71名(78.9%)顺产,19名(21.1%)剖腹产。≥6cm宫颈扩张时,AOP≥120°、PD≥2.7 cm与阴道分娩有较强相关性,敏感性70.4%、特异性94.7%、特异性63.4%、特异性89.5%。AOP bbb10°的变化(δ)具有最高的诊断准确性(81%),阳性预测值为92.2%。结论:国际电联为劳工进步提供了宝贵的见解。AOP和PD,特别是宫颈扩张≥6cm时,可预测阴道分娩。增量AOP是最准确的预测器。将国际电联纳入常规分娩管理可加强临床决策,有助于减少不必要的干预和剖腹产。
{"title":"Serial intrapartum ultrasound to predict vaginal delivery using angle of progression and head- progression distance in term nulliparous women","authors":"Rajvi Hans,&nbsp;Deepa Reddy ,&nbsp;Jyothi Shetty","doi":"10.1016/j.ejogrb.2024.12.014","DOIUrl":"10.1016/j.ejogrb.2024.12.014","url":null,"abstract":"<div><h3>Introduction</h3><div>Over the past decade, intrapartum ultrasound (ITU) has been in the global limelight for labour monitoring. The use of the same in clinical settings of low- and middle-income countries (LMIC’s) however, is limited. Till date, angle of progression (AOP) stands as the most studied parameter. Very few studies, most from developed countries, have shown that other ITU measurements could also hold relevance to labour and delivery. In recent times, serial ITU has also garnered some attention and could possibly be a better predictor of labour outcome.</div></div><div><h3>Aims</h3><div>This study aimed to compare the predictive accuracies of AOP and head PD for vaginal delivery and to investigate whether the rate of change of serially measured AOP and head PD in the first stage is predictive of vaginal delivery.</div></div><div><h3>Methods</h3><div>A prospective observational study was conducted on 90 nulliparous women between April 2023 and July 2024 at a tertiary teaching hospital in South India. Participants had singleton pregnancies in cephalic presentation between 37–40 weeks with regular contractions, and cervical dilation ≥ 3 cm. Exclusion criteria included prior LSCS and abnormal cardiotocography. Intrapartum ultrasound was performed twice, once at recruitment and 3–5 h apart, to measure AOP and PD. Statistical analysis included ROC curve plotting for diagnostic accuracy of AOP and PD in predicting vaginal delivery.</div></div><div><h3>Results</h3><div>Of the 90 participants, 71 (78.9 %) delivered vaginally and 19 (21.1 %) had caesarean sections. AOP ≥ 120° and PD ≥ 2.7 cm at ≥ 6 cm cervical dilation showed a strong correlation with vaginal delivery, with sensitivity and specificity of 70.4 % and 94.7 %, and 63.4 % and 89.5 % respectively. Change (delta) in AOP &gt; 10° had the highest diagnostic accuracy (81 %), with a positive predictive value of 92.2 %.</div></div><div><h3>Conclusion</h3><div>ITU offers valuable insights into labour progression. AOP and PD, particularly at cervical dilation of ≥ 6 cm, are predictive of vaginal delivery. Delta AOP serves as the most accurate predictor. Incorporating ITU into routine labour management enhances clinical decision-making, helping reduce unnecessary interventions and caesarean deliveries.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"305 ","pages":"Pages 125-131"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of virtual wards in maternity in the United Kingdom 虚拟病房在英国产科的作用。
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.038
Lisa Story , Melanie Nana , Megan Hall , Adam Fitzgerald , Gina Brockwell , Eugene Oteng-Ntim , Sonji Clarke , Fiona Challacombe , Catherine Nelson-Piercy , Andrew Shennan
Virtual wards are an initiative which aims to provide hospital care from the comfort of the patient’s own home. Monitoring and additional services, such as intravenous drugs and fluids and blood tests can be undertaken through this system. Although virtual wards have been used in the UK since 2005 in specialties such as General Medicine, General Surgery and Paediatrics, their use in maternity has been more limited. This article aims to review their current use in the UK and beyond as well as to discuss some of the advantages and challenges they may pose to a maternity population.
虚拟病房是一项旨在从病人舒适的家中提供医院护理的倡议。可通过该系统进行监测和其他服务,如静脉注射药物、液体和血液检查。尽管自2005年以来,虚拟病房已经在英国的普通内科、普通外科和儿科等专科使用,但它们在产科的使用却更为有限。这篇文章的目的是回顾他们目前在英国和超越的使用,以及讨论一些优势和挑战,他们可能会对产妇人口。
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引用次数: 0
The effect of dance and massage applied by spouses during childbirth on labor pain, comfort, and satisfaction 配偶在分娩过程中舞蹈和按摩对分娩疼痛、舒适和满意度的影响。
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.031
Kübra Yavaş , Ayça Şolt Kırca

Objective

The aim of this study is to evaluate the effects of endorphin massage and dance applied by spouses during labor on labor pain, satisfaction with childbirth, postpartum comfort, and person-centered maternity care.

Materials and methods

The sample of this randomized controlled experimental study consists of 105 pregnant women in their second childbirth (35 in the birth dance group,35 in the endorphin massage group, and 35 in the control group). The endorphin massage taught by the researcher to the pregnant women and their spouses was applied for 10 min. For the dance group, the birth dance, taught by the researcher to the pregnant women and their spouses, was performed for at least 15 min per session. The control group received routine midwifery care. Data were collected using the Descriptive Information Form, Visual Analog Scale, Birth Satisfaction Scale, Postpartum Comfort Scale, and Person Centered Maternity Care Scale.

Results

No significant difference was found in the total scores of the Person Centered Maternity Care scale between the groups. However, the communication and autonomy subscale scores of the massage group were significantly higher than those of the dance group. The total Birth Satisfaction Scale score of the dance group was significantly higher than those of the massage and control groups (133,17 ± 9,85; 125,54 ± 11,18; 122,4 ± 11,55, respectively). The VAS-2 scores of participants in the dance and massage groups were significantly lower than those in the control group after the interventions (4,83 ± 0,79; 4,69 ± 0,72, 7,89 ± 0,93, respectively).

Conclusion

The study found that dance and massage had a positive effect on postpartum comfort, person-centered maternity care, and childbirth satisfaction, and significantly reduced the average pain scores felt during labor.
目的:探讨配偶在分娩过程中应用内啡肽按摩和舞蹈对分娩疼痛、分娩满意度、产后舒适度和以人为本的产妇护理的影响。材料与方法:本随机对照实验研究样本为105例二胎孕妇(分娩舞蹈组35例,内啡肽按摩组35例,对照组35例)。研究人员对孕妇及其配偶进行的内啡肽按摩为10分钟。舞蹈组为研究人员对孕妇及其配偶进行的分娩舞蹈,每节至少15分钟。对照组接受常规助产护理。采用描述性信息表、视觉模拟量表、分娩满意度量表、产后舒适量表和以人为本的产妇护理量表收集数据。结果:两组间以人为本的产妇护理量表总分无显著差异。然而,按摩组的沟通和自主分量表得分显著高于舞蹈组。舞蹈组分娩满意度总分显著高于按摩组和对照组(133,17±9,85;125,54±11,18;分别为122,4±11,55)。干预后舞蹈组和按摩组VAS-2得分显著低于对照组(4,83±0,79;分别为4,69±0,72,7,89±0,93)。结论:研究发现,舞蹈和按摩对产后舒适度、以人为本的分娩护理和分娩满意度有积极的影响,并显著降低分娩时的平均疼痛评分。
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引用次数: 0
Trend and characteristics of endometrial cancer in Guangzhou from 2000 to 2020 2000 - 2020年广州地区子宫内膜癌趋势及特点
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.052
Jia Wang, YingXiang Wang, YunHui Li, XiaoMao Li

Objectives

To explore temporal trends in the age of endometrial cancer in Guangzhou over the past 21 years.

Study Design

We conducted a retrospective analysis of women diagnosed with endometrial cancer from 2000 to 2020 at a major teaching hospital in Guangzhou, China. One-way analysis of variance was utilized to compare the average age of onset for each year, while the t-test was employed to compare groups A (2000–2009) and B (2010–2020) over the 21-year period. Stratified analysis was conducted based on age group and pathological type. Chi-square and Fisher’s exact tests were utilized to compare histopathological types across different groups. Multiple linear regression analysis was used to analyze the independent factors.

Results

The number of endometrial cancer cases increased annually over the 21-years period. A total of 610 patients were included in the study. The age of onset ranged from 14 to 89 years, with a mean age of 52.9 ± 9.3 years. One-way variance analysis revealed no statistically significant difference in the mean age between years (F = 1.518, p = 0.069). When grouped into decades, the mean ages of the 2000–2009 and 2010–2020 were 53.91 ± 10.23 years and 52.69 ± 9.79 years respectively, with no statistically significant difference observed (p = 0.23). From 2000 to 2020, patients aged ≤ 45 years accounted for 18.4 % of cases, with a significant increasing trend observed over time (F= 11.10, p< 0.001). However, there was no statistically significant difference in the composition ratio of patients aged ≤ 45 years (χ2 = 13.885, p = 0.836). Patients aged ≥ 60 years accounted for 22.8 % of cases, with no significant change observed over time (F=4.782, p=0.017) and there was no difference in the composition ratio of elderly patients aged ≥ 60 years (χ2= 28.489, p= 0.098). Stratified analysis by age group and pathological type revealed no statistically significant difference in the mean age between Type 1 and Type 2 Endometrial Cancer (p = 0.18). While the proportion of Type 1 Endometrial Cancer slightly increased over time, the difference was not statistically significant (p= 0.52). Similarly, there was no statistically significant difference in the proportion of different pathological types between patients aged ≤ 45 years and patients > 45 years old (p= 0.17); however, Type 2 Endometrial Cancer, associated with higher risk, was more prevalent in patients > 45 years old.

Conclusions

The mean age of endometrial cancer in this region remained relatively stable over the past 21 years, with no observable trend towards younger or older. The proportion of young patients in this region was higher than that of other countries.
目的:探讨近21年来广州地区子宫内膜癌发病年龄的变化趋势。研究设计:我们对中国广州一家大型教学医院2000年至2020年诊断为子宫内膜癌的妇女进行了回顾性分析。采用单因素方差分析比较每年的平均发病年龄,采用t检验比较A组(2000-2009年)和B组(2010-2020年)21年间的发病年龄。按年龄组和病理分型进行分层分析。使用卡方检验和Fisher精确检验来比较不同组的组织病理类型。采用多元线性回归分析独立因素。结果:子宫内膜癌病例数在21年间逐年增加。共有610名患者参与了这项研究。发病年龄14 ~ 89岁,平均52.9±9.3岁。单因素方差分析显示,两组间平均年龄差异无统计学意义(F = 1.518, p = 0.069)。按年分,2000-2009年和2010-2020年的平均年龄分别为53.91±10.23岁和52.69±9.79岁,差异无统计学意义(p = 0.23)。2000 - 2020年,年龄≤45岁的患者占18.4%,随时间的推移呈显著上升趋势(F= 11.10, p2 = 13.885, p = 0.836)。年龄≥60岁的患者占22.8%,两组间差异无统计学意义(F=4.782, p=0.017);年龄≥60岁的老年患者构成比差异无统计学意义(χ2= 28.489, p= 0.098)。按年龄组和病理类型分层分析,1型和2型子宫内膜癌患者的平均年龄差异无统计学意义(p = 0.18)。随着时间的推移,1型子宫内膜癌的比例略有增加,但差异无统计学意义(p= 0.52)。同样,年龄≤45岁的患者与年龄≤45岁的患者不同病理类型的比例差异无统计学意义(p= 0.17);然而,风险较高的2型子宫内膜癌在45岁以下的患者中更为普遍。结论:在过去的21年中,该地区子宫内膜癌的平均年龄保持相对稳定,没有明显的年轻化或高龄化趋势。该地区年轻患者的比例高于其他国家。
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引用次数: 0
Prevalence and determinants of lower urinary tract symptoms in pregnant women 孕妇下尿路症状的患病率和决定因素
IF 2.1 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2025-02-01 DOI: 10.1016/j.ejogrb.2024.12.050
Pınar Kara

Objective(s)

The management of lower urinary tract symptoms (LUTS) is crucial for providing quality pregnancy care. This study aims to determine the prevalence and predictors of LUTS in pregnant women.

Study design

This cross-sectional study was conducted between November 2023 and February 2024 with a total of 1703 pregnant women who attended routine pregnancy care at four state hospital obstetrics outpatient clinics. Data were collected using a pregnant woman information form and the “Bristol Female Lower Urinary Tract Symptoms-Short Form (BFLUTS-SF)”. Descriptive statistics, the independent sample t-test, analysis of variance (ANOVA) test, Tukey or Tamhane’s T2 post-hoc tests, and multiple linear regression (Stepwise) analysis were carried out. All analyses were conducted with a 95 % confidence interval and a significance level of p < 0.05.

Results

The prevalence of LUTS among pregnant women was found to be 99.2 %. High prevalence rates were obtained for storage symptoms, voiding symptoms, and urinary incontinence symptoms (respectively, 99.2 %, 48.8 %, and 61.2 %). Multiple linear regression analysis indicated that previous pregnancy stress urinary incontinence (SUI), history of curettage and urinary tract infection (UTI), absence of episiotomy, presence of SUI in the mother and/or sister, smoking, being employed, and being in the third trimester are significant predictors of LUTS during pregnancy (p < 0.05).

Conclusion(s)

The findings of this study indicate that LUTS is commonly in pregnant women. For quality pregnancy care, it is recommended to organize community-based, repeated educational programs and counseling services aimed at preventing and reducing LUTS in women.
目的:管理下尿路症状(LUTS)是提供高质量妊娠护理的关键。本研究旨在确定妊娠妇女LUTS的患病率和预测因素。研究设计:本横断面研究于2023年11月至2024年2月期间进行,共有1703名孕妇在四家州立医院产科门诊诊所接受常规妊娠护理。使用孕妇信息表和“布里斯托尔女性下尿路症状简表(BFLUTS-SF)”收集数据。采用描述性统计、独立样本t检验、方差分析(ANOVA)检验、Tukey或Tamhane’s T2事后检验和多元线性回归(Stepwise)分析。所有分析的置信区间为95%,显著性水平为p。结果:LUTS在孕妇中的患病率为99.2%。积液症状、排尿症状和尿失禁症状的患病率较高(分别为99.2%、48.8%和61.2%)。多元线性回归分析显示,妊娠应激性尿失禁(SUI)、刮除和尿路感染(UTI)史、未进行会阴切开术、母亲和/或姐妹存在SUI、吸烟、在职、妊娠晚期是妊娠期LUTS的重要预测因素(p)。对于高质量的妊娠护理,建议组织以社区为基础的、反复的教育项目和咨询服务,旨在预防和减少妇女的LUTS。
{"title":"Prevalence and determinants of lower urinary tract symptoms in pregnant women","authors":"Pınar Kara","doi":"10.1016/j.ejogrb.2024.12.050","DOIUrl":"10.1016/j.ejogrb.2024.12.050","url":null,"abstract":"<div><h3>Objective(s)</h3><div>The management of lower urinary tract symptoms (LUTS) is crucial for providing quality pregnancy care. This study aims to determine the prevalence and predictors of LUTS in pregnant women.</div></div><div><h3>Study design</h3><div>This cross-sectional study was conducted between November 2023 and February 2024 with a total of 1703 pregnant women who attended routine pregnancy care at four state hospital obstetrics outpatient clinics. Data were collected using a pregnant woman information form and the “Bristol Female Lower Urinary Tract Symptoms-Short Form (BFLUTS-SF)”. Descriptive statistics, the independent sample <em>t</em>-test, analysis of variance (ANOVA) test, Tukey or Tamhane’s T2 post-hoc tests, and multiple linear regression (Stepwise) analysis were carried out. All analyses were conducted with a 95 % confidence interval and a significance level of p &lt; 0.05.</div></div><div><h3>Results</h3><div>The prevalence of LUTS among pregnant women was found to be 99.2 %. High prevalence rates were obtained for storage symptoms, voiding symptoms, and urinary incontinence symptoms (respectively, 99.2 %, 48.8 %, and 61.2 %). Multiple linear regression analysis indicated that previous pregnancy stress urinary incontinence (SUI), history of curettage and urinary tract infection (UTI), absence of episiotomy, presence of SUI in the mother and/or sister, smoking, being employed, and being in the third trimester are significant predictors of LUTS during pregnancy (p &lt; 0.05).</div></div><div><h3>Conclusion(s)</h3><div>The findings of this study indicate that LUTS is commonly in pregnant women. For quality pregnancy care, it is recommended to organize community-based, repeated educational programs and counseling services aimed at preventing and reducing LUTS in women.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"305 ","pages":"Pages 375-380"},"PeriodicalIF":2.1,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142930861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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European journal of obstetrics, gynecology, and reproductive biology
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