European journal of obstetrics, gynecology, and reproductive biology最新文献

{"title":"A feasibility study of magnetic resonance pelvimetry in women of short stature to identify the risk of cephalo-pelvic disproportion","authors":"Amin Z ,&nbsp;Wilson C ,&nbsp;Offiah I ,&nbsp;Puckett M ,&nbsp;Musicha C ,&nbsp;Dua A ,&nbsp;Freeman R","doi":"10.1016/j.ejogrb.2024.10.001","DOIUrl":"10.1016/j.ejogrb.2024.10.001","url":null,"abstract":"<div><h3>Objective</h3><div>To conduct a feasibility study to assess if MR Pelvimetry can be undertaken in short stature primigravidae, with a view to a main study to answer the question ‘can MR pelvimetry be used to predict cephalo-pelvic disproportion (CPD) in women of short stature?’.</div></div><div><h3>Study Design</h3><div>This was a prospective single arm feasibility study. In the first phase, patient and public involvement was undertaken to assess acceptability of the study. In the second phase, primiparous women of ≤ 160 cm in height were selected from antenatal clinics. Obstetricians and midwives were asked to inform all eligible women about the study. Patients were approached in the third trimester and written information about the study provided. If the patient agreed to participate, they were invited for consent. MR scans were performed from 36 weeks gestation. Patients and their obstetricians were not informed of the results of the MR until <em>after</em> delivery (in view of NICE and WHO recommendations on pelvimetry).</div></div><div><h3>Results</h3><div>MR scans were performed on 21/35 (60%) participants who consented. The study was conducted without adverse events and was acceptable to all participants. Data were available from 19 patients; 7 (37%) of whom had caesarean section (CS) due to CPD, 7 (37%) had assisted vaginal birth (AVB), while 5 (26%) had spontaneous vaginal births (SVD). Two patients who had an elective CS were not included in the analysis. The pelvic measurements especially anatomical conjugate (inlet), transverse diameter (mid cavity) and anteroposterior diameter at the outlet were larger in the SVD group in comparison to in-labour CS /AVB. Interobserver MR scan measurements were comparable between radiologists: intraclass correlation coefficient (ICC) range 0.68 to 0.95.</div></div><div><h3>Conclusion</h3><div>This feasibility study suggests that conducting a full study to answer the research question ‘<em>can MR pelvimetry predict CPD in women of short stature</em>?<em>’<!--> </em>would be feasible and acceptable to patients. The recruitment, MR scan protocol, reporting, reliability of measures were all assessed and found acceptable for a trial. A trend was observed for smaller pelvic measurements in women who needed intervention compared with those who had a natural birth/SVD. With evidence from a full trial, this could have major implications for the management of short stature women, in terms of clinical practice and safety.</div></div><div><h3>Key messages</h3><div>A large trial would be feasible and acceptable to assess whether MR pelvimetry can predict CPD in women of short stature. Despite the small number of patients, a trend was observed for smaller pelvic measurements in women who needed intervention compared to those who had spontaneous vaginal birth. Evidence from a large trial could help inform clinical practice, and provide information and choice for women at risk of CPD.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"303 ","pages":"Pages 78-84"},"PeriodicalIF":2.1,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the current medico-legal and regulatory culture in Ireland on the decision of graduate entry medical school students to pursue a career in obstetrics and gynecology","authors":"Mary-Elizabeth Tumelty ,&nbsp;Eimear Spain ,&nbsp;Ayesha Cheema ,&nbsp;Kaitlyn Cinnamond ,&nbsp;Ailish Hannigan ,&nbsp;Santosh Sharma ,&nbsp;Amanda Cotter","doi":"10.1016/j.ejogrb.2024.10.015","DOIUrl":"10.1016/j.ejogrb.2024.10.015","url":null,"abstract":"<div><h3>Objectives</h3><div>Medico-legal and regulatory culture has a significant impact on medical practitioners, including the decision of graduates to enter high-risk specialties. This study explores the impact of the current medico-legal and regulatory culture in Ireland on the decision of graduate entry medical students to enter one high risk specialty, obstetrics and gynecology.</div></div><div><h3>Study Design</h3><div>We conducted a survey of 146 final-year, graduate-entry medical students pre- and post- a 6-week rotation in obstetrics and gynecology in Ireland. Participants were asked to rate the influence (on a four-point scale) of factors such as fear of being sued, being reported to the regulatory body or criminal prosecution on their decision to pursue a career in obstetrics or gynaecology. Data were matched pre- and post-rotation and McNemar-Bowker’s test was used to test for differences in related data. All analysis was conducted using SPSS for Windows version 25.</div></div><div><h3>Results</h3><div>The responses of 72 students to both questionnaires could be matched (response rate 49.3%). The majority of participants pre-rotation reported that fear of being sued (74%), fear of being reported to the regulatory body (70%) and fear of criminal prosecution (55%) were factors influencing their decision (somewhat or to a great extent) to pursue a career in obstetrics. There were no significant changes post-rotation. Compared to obstetrics, lower proportions of participants pre-rotation considered fear of being sued (54%), fear of being reported to the regulatory body (50%) and fear of criminal prosecution (40%) as factors influencing their decision to pursue a career in gynecology. There were no significant changes post-rotation.</div></div><div><h3>Conclusions</h3><div>Medico-legal and regulatory culture is shaping the perceptions of graduate entry medical students of obstetrics and gynecology and influencing their decision to pursue a career in the speciality. Understanding the impact of medico-legal culture on career choices including a high-risk specialty such as obstetrics and gynecology is important from both a policy and reform context, and if the healthcare service is to recruit and retain adequate numbers to ensure the safe provision of healthcare.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"303 ","pages":"Pages 42-47"},"PeriodicalIF":2.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142441208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher serum progesterone level has no negative impact on live birth rate in frozen embryo transfer","authors":"Mauro Cozzolino ,&nbsp;Irene Hervás ,&nbsp;Yagmur Ergun ,&nbsp;Maria Giulia Massaro ,&nbsp;Nuria Pellicer ,&nbsp;Franco de Angelis ,&nbsp;Elena Labarta ,&nbsp;Daniela Galliano","doi":"10.1016/j.ejogrb.2024.10.011","DOIUrl":"10.1016/j.ejogrb.2024.10.011","url":null,"abstract":"<div><div>Optimal synchronisation between the endometrium and the embryo is key to the success of frozen embryo transfers (FET). It is achieved by administering different doses of exogenous oestrogen and progesterone (P4). The negative impact of low levels of P4 on FET has been reported, but there is a lack of knowledge about which levels are most appropriate. We aimed to evaluate whether high serum P4 levels measured on FET day affect the probability of having a baby at home. This retrospective cohort study includes 7546 FET cycles performed with hormone replacement therapy (HRT) for artificial endometrial preparation. Patients were divided into three groups according to P level on FET day (ng/mL): P4 &lt; 20(n = 6623), P4 ≥ 20–40 (n = 770) and P &gt; 40 (n = 146). Female age was per group P4 &lt; 20 = 38.7 ± 3.1, P ≥ 20–40 = 39.0 ± 3.0, and P4 &gt; 40 = 38.1 ± 2.9 years old (p = 0.53). The group with the highest progesterone levels found lower ongoing pregnancy rates without statistical significance (56.3 % (P4 &lt; 20) vs 56.8 % (P4 ≥ 20-&lt;40) vs 51.4 % (P4 &gt; 40); p = 0.5). Miscarriage rate was also higher, although not significantly: 16.2 % (P4 &lt; 20) vs 15.0 % (P4 ≥ 20-&lt;40) vs 18.0 % (P4 &gt; 40) (p = 0.6). These findings were explored with an adjusted analysis. A higher, but not significant, odds of miscarriage was observed when P4 &gt; 40 ng/ml, aOR = 1.14 (0.75–1.74) (p = 0.55) whereas no such association was found with P4 ≥ 20–40 ng/ml (aOR = 0.92 (0.74–1.15) (p = 0.46)). The probability of livebirth is similar when the patient was P4 &gt; 40 (aOR = 0.77 (0.51–1.15) (p = 0.20)) than when P4 ≥ 20-&lt;40 (aOR = 0.94 (0.79–1.11) (p = 0.47). In conclusion, women with elevated serum P4 levels on the day of FET after HRT do not find their probability of live birth impaired.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"303 ","pages":"Pages 15-21"},"PeriodicalIF":2.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The HYsteroscopic Miscarriage MaNagement (HYMMN) pilot randomized-controlled trial","authors":"Prathiba M. De Silva ,&nbsp;Oonagh Pickering ,&nbsp;Natalie Woodhead ,&nbsp;B. Zeyah F. Sairally ,&nbsp;Siobhan O’Connor ,&nbsp;Paul P. Smith ,&nbsp;Arri Coomarasamy ,&nbsp;T. Justin Clark","doi":"10.1016/j.ejogrb.2024.10.010","DOIUrl":"10.1016/j.ejogrb.2024.10.010","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the feasibility of performing a full-scale, adequately powered, multi-center randomized controlled trial (RCT) assessing the effectiveness of office hysteroscopy (OH) for the treatment of retained pregnancy tissue (RPT) after miscarriage, compared with standard treatment (ST) (expectant/medical/surgical), on future pregnancy outcome.</div></div><div><h3>Study design</h3><div>Single-center pilot RCT performed at Birmingham Women’s Hospital, UK. Patients opting for non-surgical miscarriage management at ≤14 weeks gestation who wanted to conceive as soon as possible were recruited and offered a transvaginal ultrasound scan (TVUS) eight weeks later to check for the presence of RPT. Patients with RPT were randomized in a 1:1 ratio using a computer-generated online random allocation sequence to either OH (performed using the TruClear 5.0 hysteroscopic tissue retrieval system) or ST (the type of which was recommended based on symptoms, urinary pregnancy test and scan findings).</div></div><div><h3>Results</h3><div>158 participants were approached for inclusion into the trial, of which 149 (94.3%) agreed. Of the 126 that underwent TVUS, RPT were diagnosed in 42 patients (33.3%). 21 patients were randomized to OH, of whom 18 underwent the procedure because three fell pregnant after their TVUS. OH was deemed acceptable to all patients without any serious complications. 21 patients were randomized to ST where 16 patients (76%) were recommended expectant management and five (24%) were recommended surgical management. 115 patients (91%) were able to provide pregnancy data, however, the study was not powered to show a clinically significant difference.</div></div><div><h3>Conclusion</h3><div>A full-scale, adequately powered, randomized clinical trial investigating OH against ST for the treatment of RPT following miscarriage is clinically relevant and feasible owing to high rates of participation, acceptability and satisfaction and low rates of attrition associated with the proposed interventions.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"302 ","pages":"Pages 375-380"},"PeriodicalIF":2.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptake of gynecological consultation following domestic or sexual violence: A case-control study in the context of induced abortion","authors":"Elisabeth Iraola ,&nbsp;Jean-Pierre Menard ,&nbsp;Marie-Laure Baranne ,&nbsp;Julien Cudonnec ,&nbsp;Isabelle Buresi ,&nbsp;Patrick Chariot","doi":"10.1016/j.ejogrb.2024.10.016","DOIUrl":"10.1016/j.ejogrb.2024.10.016","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to determine the prevalence of domestic and sexual violence and to characterize the association between exposure to domestic and sexual violence and low uptake of gynecological care, in the context of induced abortion.</div><div>Study design.</div><div>We conducted a case-control study among women seeking abortion care, in mother and child centers and sexual health centers in the Paris, France area (April 2022-March 2023).</div></div><div><h3>Results</h3><div>A total of 103 women were included in the study during induced abortion care. Physical, psychological or sexual domestic violence was reported by 48.5 % and sexual violence, whoever the perpetrator, was reported by 23.3 %. In the bivariate analysis, a history of physical, psychological or sexual domestic violence was not associated with the absence of a gynecological consultation in the past two years, compared with no history of intimate partner violence (p = 0.09). After adjustment for regular pelvic pain, dysmenorrhea, vulvodynia and dyspareunia, there was no association between a history of sexual violence and the absence of a gynecological consultation in the past two years (OR 1.05; CI95% 0.27–4.13, p = 0.93).</div></div><div><h3>Conclusion</h3><div>Violence was a common finding among women seeking abortion care. We did not find any association between a history of sexual violence and the absence of a gynecological consultation in the past two years. We suggest investigating multiple or frequent use of gynecological care following violence. The combination of ethical, moral, and psychological constraints associated with violence screening and abortion care is a challenge to patient recruitment in future studies.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"303 ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of 3a obstetric anal sphincter injury repairs in a teaching hospital: Subjective and objective outcomes","authors":"Joy L.M. Troko-Alawale ,&nbsp;Hannah M. Nazri ,&nbsp;Supriya Bulchandani","doi":"10.1016/j.ejogrb.2024.10.013","DOIUrl":"10.1016/j.ejogrb.2024.10.013","url":null,"abstract":"<div><h3>Introduction</h3><div>The Royal College of Obstetricians and Gynaecologists (RCOG) recommends offering elective caesarean sections (CS) for subsequent deliveries to obstetric anal sphincter injury (OASI) patients with anorectal dysfunction, or abnormal endoanal ultrasonography (EA USS), and/or anal manometry (AM). (1) Asymptomatic OASI patients however, are not always offered EA USS or AM due to limited access to diagnostic resources across the United Kingdom, particularly those with 3a tears. This paper reviews subjective and objective outcomes in women with 3a tears and aims to add to the body of literature supporting good practice and management.</div></div><div><h3>Objectives</h3><div>Identify the incidence of defects in patients with 3a tears following a primary repair and compare the rate and extent of defects found on EA USS between symptomatic and asymptomatic women.</div></div><div><h3>Study Design</h3><div>We performed a retrospective study of 69 women following primary repair of 3a OASI tears in a tertiary referral perineal clinic between January 2020 and December 2022. Symptoms were evaluated using the St Mark’s Score for anal incontinence (SMI) and Starck score for defects on EA USS. Findings were analyzed using R Foundation Statistical Software (version 4.2.2, 2022).</div></div><div><h3>Results</h3><div>Out of the total, 42 % (29/69) had defects on EA USS and 30 % (21/69) of women were symptomatic. Thirty eight percent (18/48) of asymptomatic women were noted to have defects compared with 52 % (11/21) of symptomatic patients. Majority of defects were situated in the upper and mid anal canal (69 %) either as &lt;1 hr or &gt;3 hr hypoechoic areas. There was no significant difference in defect rate (<em>X</em>² = 2.06, <em>p</em> = 0.15) or Starck score (2.23 v 1.53, <em>p</em> = 0.22) between the two groups. However those delivered by forceps (<em>p</em> = 0.004) and of Asian ethnicity (<em>p</em> = 0.01) were more likely to be symptomatic.</div></div><div><h3>Conclusion</h3><div>EA USS should be offered to all patients following an OASI, as symptoms alone are not predictive of anorectal compromise in structure and/or function. Asymptomatic patients with 3a tears should be informed that there is up to a 40% chance of finding a defect on EA USS.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"303 ","pages":"Pages 141-145"},"PeriodicalIF":2.1,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal-hope study: Home monitoring of fetal heart rate in SSA + pregnant women: Rationale and design","authors":"A. Mauro ,&nbsp;E. Bizzi ,&nbsp;C. Caccia Dominioni ,&nbsp;R. Milazzo ,&nbsp;L. Serati ,&nbsp;M. Nivuori ,&nbsp;M. Quartarone ,&nbsp;L. Bernardo ,&nbsp;M.C. Gerardi ,&nbsp;M. Fredi ,&nbsp;I. Cetin ,&nbsp;A.L. Brucato","doi":"10.1016/j.ejogrb.2024.10.009","DOIUrl":"10.1016/j.ejogrb.2024.10.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Worldwide, approximately 0.5–1 % of women of childbearing age are positive for anti-Ro/SSA antibodies and anti-La/SSB. The presence of these antibodies may be responsible for the appearance of Neonatal Lupus. The pathogenesis of this disease is probably mediated by the binding of these antibodies to fetal myocardiocytes. The typical manifestation is atrioventricular block (AVB), which in most cases is complete (CHB). AVB commonly develops between 16 and 26 weeks of gestation and is cause of severe heart failure. CHB appears to be irreversible, but anecdotal reports suggest that treatment of second-degree AVB can restore sinus rhythm.</div></div><div><h3>Objective</h3><div>The aim of the study is to evaluate the reliability of home monitoraing of fetal heart rate by the use of a hand-held device, extablishing the incidence of fetal AVB in pregnant women positive for anti-Ro/SSA autoantibodies and to evaluate whether early treatment can influence the course of the disease.</div></div><div><h3>Methods</h3><div>Anti-Ro/SAA positive pregnant women are currently recruited from 11 Italian centers in a prospective observational study. Patients are instructed to use a portable doppler between 16 and 34 weeks of gestation and to monitor the fetal heart rate (FHR) every 8 h. In case of FHR anomalies patients will contact the reference center which will guarantee an echocardiogram within 8 h and in case of anomalies, adequate treatment. All patients will undergo check-ups at 20, 26 and 32 weeks of gestation, with the collection of information on the course of the maternal disease, on the use of drugs and on instrumental monitoring progress.</div><div>After birth, data will be collected on the outcome of pregnancy and the methods of delivery. Newborns will also be evaluated for the possible appearance of clinical signs of Neonatal Lupus.</div></div><div><h3>Results</h3><div>Fetal-Hope is actually enrolling Patients from involved Centers.</div></div><div><h3>Conclusions</h3><div>Fetal-Hope is the first European study assessing the reliability of home monitoring of fetal heart rate using a handheld device, determining the incidence of fetal atrioventricular block (AVB) in pregnant women positive for anti-Ro/SSA autoantibodies and assessing whether early intervention can alter the disease’s progression.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"303 ","pages":"Pages 99-103"},"PeriodicalIF":2.1,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive parallel sequencing-based non-invasive prenatal test (NIPT) identifies aberrations on chromosome 13","authors":"Maria Sobol ,&nbsp;Christos Aravidis ,&nbsp;Hugo Hessel ,&nbsp;Anna Lindqvist ,&nbsp;Izabella Baranowska Körberg","doi":"10.1016/j.ejogrb.2024.10.007","DOIUrl":"10.1016/j.ejogrb.2024.10.007","url":null,"abstract":"<div><h3>Objective</h3><div>We report data of non-invasive prenatal testing (NIPT) at Uppsala University Hospital between 2017–2022. Furthermore, we illustrate the potential capacity of massive parallel sequencing-based NIPT beyond identification of common trisomies.</div></div><div><h3>Methods</h3><div>Maternal blood samples were analyzed using the Verifi NIPT or VeriSeq NIPT assays. Diagnostic testing, performed on amniotic fluid samples, included QF-PCR, microarray (SNP-array) and metaphase FISH.</div></div><div><h3>Results</h3><div>Among 4532 NIPT tests performed between 2017–2022, 125 samples (2.76%) showed increased risk for trisomies 13, 18, 21 and sex chromosome aneuploidy. For three patients with normal NIPT result further microarray indicated other types of chromosomal rearrangement which were not analyzed by NIPT. For another patient (case 1) the Verifi NIPT indicated trisomy 13. Fetal fraction (FF) was estimated to be 10%. Confirmatory microarray detected a segmental duplication on chromosome 13, as well as a terminal duplication and a terminal deletion on chromosome 10. A complex karyotype was observed in the fetus with metaphase FISH. In the second case the VeriSeq NIPT indicated trisomy 13. FF was estimated to be 11%. Confirmatory microarray detected a mosaicism of trisomy 13 in 30 % of cells.</div></div><div><h3>Conclusion</h3><div>This study illustrates detection of peculiar abnormalities of chromosome 13 and supports potential to screen copy number variations with genome-wide NIPT.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"302 ","pages":"Pages 370-374"},"PeriodicalIF":2.1,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142406278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI in obstetrics: Evaluating residents' capabilities and interaction strategies with ChatGPT: Correspondence.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1016/j.ejogrb.2024.10.004","DOIUrl":"https://doi.org/10.1016/j.ejogrb.2024.10.004","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological impact of neovagina creation and uterus transplantation in the patients affected from Mayer–Rokitanski–Kuster–Hauser syndrome: A narrative review","authors":"Basilio Pecorino ,&nbsp;Giuseppe Scibilia ,&nbsp;Martina Ferrara ,&nbsp;Pierfrancesco Veroux ,&nbsp;Liliana Mereu ,&nbsp;Alessandro Serretti ,&nbsp;Paolo Scollo","doi":"10.1016/j.ejogrb.2024.09.041","DOIUrl":"10.1016/j.ejogrb.2024.09.041","url":null,"abstract":"<div><div>Mayer–Rokitanski–Kuster–Hauser (MRKH) syndrome consists of a congenital aplasia of the uterus and the upper part of the vagina. It is the most frequent congenital cause of absolute uterine factor infertility, determining psychological disorders due to infertility and reduced quality of sexual activity. Being the necessity of baseline and prolonged assessments, clinicians need evaluation parameters for the monitoring of patients to plan a suitable management strategy and for efficient support before and after interventions, such as neovagina and uterus transplantation.</div><div>Research of the literature was performed in PubMed and SCOPUS by searching for the terms “Mayer-Rokitanski-Kuster-Hauser” AND “psychological disorders”; from the 60 articles obtained, only 35 articles regarding neovagina creation and uterus transplantation were considered for the present manuscript.</div><div>Based on the literature, management of MRKH syndrome by neovagina creation, either surgically or not, can restore a satisfactory sexual life and to reduce stress, signs of mental disorder and depression and improve sexual activity and quality of life.</div><div>A psychological assessment of candidates to UT and of their partners is necessary. Recipients had low levels of anxiety compared to the normal population at baseline but a transiently lowered physical quality of life 1 year after surgery; elevated anxiety scores are associated with childlessness in the long-term evaluation.</div><div>Further research is necessary to develop suitable evaluation protocols and adequate supportive services, to improve the outcomes of patients who undergo neovagina creation and uterus transplantation.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"302 ","pages":"Pages 356-361"},"PeriodicalIF":2.1,"publicationDate":"2024-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}