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Role of mediolateral or lateral episiotomy in preventing obstetric anal sphincter injury (OASI) in nulliparous women undergoing vacuum-assisted delivery: A systematic review and meta-analysis 中外侧或外阴切开术在预防无产妇女接受真空辅助分娩时产科肛门括约肌损伤(OASI)中的作用:一项系统回顾和荟萃分析
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-05 DOI: 10.1016/j.ejogrb.2026.114939
Giovanni Morganelli , Gabriella Maria Celora , Maria Chiara Bassi , Andrea Dall’Asta , Maurizio Di Serio , Vito Andrea Capozzi , Tullio Ghi , Stefania Fieni

Background

The potential preventive effect of mediolateral and lateral episiotomy on the risk of anal sphincter injury related to vacuum delivery in nullipara has been reported by different well-designed studies in the last years.

Objectives

The aim of this systematic review and meta-analysis is to summarize the available evidence on the protective effect of mediolateral or lateral episiotomy towards the occurrence of obstetric anal sphincter injury (OASI) in nulliparous women who were submitted to vacuum-assisted delivery.
Search strategy: PubMed, Embase, CINAHL, Cochrane Library and Scopus databases were retrospectively searched without any temporal restriction up to March 1st 2025.
Selection criteria: Randomized controlled trials, retrospective, prospective case-control or cohort studies investigating the incidence of perineal tears involving anal sphincter muscles and/or rectal mucosa after vacuum-assisted birth with and without mediolateral/lateral episiotomy in nulliparous women were included.
Data collection and analysis: Risk of bias assessment was conducted for each included study by applying ROB2 score for RCTs and ROBINS-I score for non-randomized studies. Data were extracted and analyzed with Review Manager 5.4.1, results were reported by means of pooled Odd-ratios (ORs) and presented as Forest plots.
Main results: 31 studies (3 RCTs and 28 non-randomized studies) were included. Cumulative sample size consisted in 608,359 nulliparous women who were submitted to vacuum-assisted delivery. Mediolateral/lateral episiotomy was found to halve the incidence of OASI (OR 0.56 [95 % CI 0.42–0.73]) with high between-study heterogeneity reported (I2 = 99 %). At sensitivity analysis, a significant reduction in OASI incidence in case of mediolateral/lateral episiotomy was confirmed (OR 0.58 [95 %CI 0.44–0.78]); this analysis was conducted on low/moderate risk of bias studies (1RCT e 5 non-randomized studies, 15,799 patients) and associated with low heterogeneity (I2 = 42 %).

Conclusions

This updated meta-analysis on the role of mediolateral/lateral episiotomy in nulliparous women submitted to vacuum assisted delivery confirms its protective role from OASI.
背景:在过去的几年里,不同的精心设计的研究已经报道了外阴中外侧切开术对肛门括约肌损伤风险的潜在预防作用。目的:本系统回顾和荟萃分析的目的是总结关于真空辅助分娩的未产妇女中外阴切开或外阴切开对产科肛门括约肌损伤(OASI)发生的保护作用的现有证据。检索策略:回顾性检索PubMed, Embase, CINAHL, Cochrane Library和Scopus数据库,无任何时间限制,截止到2025年3月1日。选择标准:包括随机对照试验、回顾性、前瞻性病例对照或队列研究,这些研究调查了无产妇女在有或没有外阴中外侧切开术的真空辅助分娩后涉及肛门括约肌和/或直肠粘膜的会阴撕裂的发生率。资料收集与分析:随机对照试验采用ROB2评分,非随机试验采用ROBINS-I评分,对每项纳入的研究进行偏倚风险评估。采用Review Manager 5.4.1软件对数据进行提取和分析,结果以混合奇比(or)报告,并以Forest样地表示。主要结果:纳入31项研究(3项rct和28项非随机研究)。累积样本量包括608359名接受真空辅助分娩的无产妇女。发现外阴内外侧切开术使OASI的发生率减少一半(OR 0.56 [95% CI 0.42-0.73]),研究间异质性较高(I2 = 99%)。在敏感性分析中,证实外阴中外侧切开术的OASI发生率显著降低(OR 0.58 [95% CI 0.44-0.78]);本分析是在低/中等偏倚风险研究(1RCT和5个非随机研究,15799例患者)中进行的,并且与低异质性相关(I2 = 42%)。结论:这一最新的荟萃分析证实了真空辅助分娩的无产妇女中外阴中外侧切开术的保护作用。
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引用次数: 0
Microbiota and infertility: a translational review of mechanisms and clinical applications in assisted reproduction 微生物群与不孕症:辅助生殖机制和临床应用的翻译综述
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-05 DOI: 10.1016/j.ejogrb.2026.114941
Bixiu Du , Yaru Yang , Lang He , Ying Tang
Infertility constitutes a major global health concern, affecting approximately 17.5% of couples of reproductive age. Although advances in assisted reproductive technologies (ART) have expanded treatment options, success rates remain highly variable due to host-specific and biological determinants. This review synthesizes current evidence on the reproductive impact of the human microbiota and its translational relevance to ART outcomes. Vaginal microbial communities dominated by Lactobacillus, particularly L. crispatus, are associated with improved conception and implantation, whereas genital or intestinal dysbiosis correlates with infertility and suboptimal treatment responses. The microbiota modulates reproductive competence through intertwined immune, endocrine–metabolic, and mucosal barrier pathways that regulate inflammation, hormonal balance, and epithelial integrity. Emerging findings indicate that gut microbial alterations linked to polycystic ovary syndrome (PCOS) and endometriosis are accompanied by insulin resistance and chronic inflammation, impairing ovulation, endometrial receptivity, and embryo viability. Interventions such as probiotics and synbiotics yield heterogeneous efficacy; individualized antimicrobial strategies, metabolic modulation, and lifestyle optimization may offer complementary benefit, while microbiota reconstruction remains experimental. Methodological limitations, including contamination in low biomass samples, variations in sequencing workflows, and population heterogeneity, still hinder data comparability and mechanistic interpretation. Future research should prioritize adequately powered randomized controlled trials using standardized microbiome metrics and live birth as a primary endpoint. Integrating microbiome profiling into ART workflows may refine patient stratification and inform precision adjuvant therapies. However, clinical implementation requires stronger causal evidence, validated biomarkers, and harmonized methodological frameworks to translate microbiome discoveries into reproducible reproductive gains.
不孕不育是一个主要的全球健康问题,影响到约17.5%的育龄夫妇。尽管辅助生殖技术(ART)的进步扩大了治疗选择,但由于宿主特异性和生物学决定因素,成功率仍然高度可变。这篇综述综合了目前关于人类微生物群对生殖影响的证据及其与抗逆转录病毒治疗结果的转化相关性。以乳酸菌为主的阴道微生物群落,尤其是脆皮乳杆菌,与受孕和着床的改善有关,而生殖器或肠道生态失调与不孕和治疗反应不佳有关。微生物群通过相互交织的免疫、内分泌代谢和粘膜屏障途径调节生殖能力,这些途径调节炎症、激素平衡和上皮完整性。新的研究结果表明,与多囊卵巢综合征(PCOS)和子宫内膜异位症相关的肠道微生物改变伴随着胰岛素抵抗和慢性炎症,影响排卵、子宫内膜容受性和胚胎活力。干预措施,如益生菌和合成菌产生不同的疗效;个性化的抗菌策略、代谢调节和生活方式优化可能提供互补的益处,而微生物群重建仍处于实验阶段。方法上的限制,包括低生物量样本的污染、测序工作流程的变化和种群异质性,仍然阻碍了数据的可比性和机制解释。未来的研究应优先考虑使用标准化微生物组指标和活产作为主要终点的充分有力的随机对照试验。将微生物组分析整合到ART工作流程中可以改进患者分层,并为精确的辅助治疗提供信息。然而,临床实施需要更有力的因果证据、经过验证的生物标志物和统一的方法框架,才能将微生物组的发现转化为可重复的生殖收益。
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引用次数: 0
Should we modify eligibility criteria for fetal surgery for open spinal dysraphism? 我们是否应该修改开放性脊柱畸形胎儿手术的资格标准?
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-04 DOI: 10.1016/j.ejogrb.2025.114912
Jean-Marie Jouannic , Anaïs Dugas , Paul Maurice , Ferdinand Dhombres , Catherine Garel , Éléonore Blondiaux , Timothée de Saint Denis , Lucie Guilbaud
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引用次数: 0
Lactobacillus, vitamin C, cranberry and hibiscus versus placebo for prolonging the latency period of premature rupture of membranes: a double-blind randomized clinical trial 乳杆菌、维生素C、蔓越莓和木槿与安慰剂对延长胎膜早破潜伏期的疗效:一项双盲随机临床试验
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-03 DOI: 10.1016/j.ejogrb.2026.114938
Iris Janeth Portillo Gonzales , Ramon Armando Lobo Oliva , Betsaida María Colindres Cruz , Lessy Yolanda Díaz Galeas , Ricardo Arturo Gutierrez-Ramirez

Objective

To evaluate the effect of a supplement blend (lactobacillus, vitamin C, cranberry and hibiscus) on the latency period after preterm premature rupture of membranes (PPROM).

Study design

A single-center, randomized (1:1), double-blind, placebo-controlled trial enrolled 84 patients with PPROM (24–34 weeks). Participants were assigned to daily oral supplements or an identical placebo. The primary outcome was the latency period from membrane rupture to delivery. Analysis was by intention-to-treat.

Result

The mean latency period was significantly longer in the intervention group compared to the placebo group (11.7 ± 7.2 days vs. 7.6 ± 4.8 days; mean difference 4.1 days, 95 % CI 1.4–6.8; p = 0.003). The standardized mean difference (Cohen’s d) was 0.67 (95 % CI 0.23–1.10), indicating a moderate-to-large effect size. Exploratory analysis suggested a more pronounced effect when treatment was initiated before 32 weeks and continued for over six days.

Conclusion

Supplementation with lactobacillus, vitamin C, cranberry and hibiscus significantly prolonged the latency period in PPROM, which may represent a low-cost adjunct to conservative management.
目的:评价乳杆菌、维生素C、蔓越莓和木槿混合补充剂对早产儿胎膜早破潜伏期的影响。研究设计:单中心、随机(1:1)、双盲、安慰剂对照试验,纳入84例PPROM患者(24-34周)。参与者被分配每日口服补充剂或相同的安慰剂。主要观察指标是从胎膜破裂到分娩的潜伏期。通过意向治疗进行分析。结果:干预组的平均潜伏期明显长于安慰剂组(11.7±7.2天比7.6±4.8天;平均差4.1天,95% CI 1.4-6.8; p = 0.003)。标准化平均差(Cohen’s d)为0.67 (95% CI 0.23-1.10),表明存在中等到较大的效应量。探索性分析表明,当治疗在32周前开始并持续6天以上时,效果更明显。结论:补充乳酸菌、维生素C、蔓越莓和木槿可显著延长PPROM的潜伏期,这可能是一种低成本的保守治疗方法。
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引用次数: 0
Robotic indocyanine green-guided sentinel lymph node mapping in early-stage cervical cancer: The fluorescent robotic indocyanine endoscopic node detection series (FRIENDS) 机器人吲哚菁绿色引导早期宫颈癌前哨淋巴结定位:荧光机器人吲哚菁内镜淋巴结检测系列(FRIENDS)
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-02 DOI: 10.1016/j.ejogrb.2025.114927
Rahul Chatterjee , Marielle Nobbenhuis , Jenneke Kasius , Manou Kaur , Katherine Vroobel , Ayoma Attygalle , Thomas Edward James Ind

Objectives

To describe the implementation of robotic indocyanine green (ICG)–guided sentinel lymph node (SLN) mapping for nodal staging in early-stage cervical cancer and to report mapping outcomes, anatomical distribution of SLNs, and perioperative morbidity.

Methods

This single-centre cohort study included women with presumed early-stage cervical cancer who underwent robotic ICG-guided SLN mapping between 2015 and 2025. SLN mapping was performed with or without pelvic lymphadenectomy according to a side-specific algorithm. Institutional practice evolved over time from routine SLN mapping with lymphadenectomy to selective SLN-only staging. Outcomes included SLN detection rates, anatomical distribution of SLNs, nodal metastases, and postoperative morbidity.

Results

A total of 161 women underwent robotic SLN mapping. SLN detection was achieved in all patients, with bilateral mapping in 145 (90.1 %). Sixteen women (9.9 %) had nodal metastases; all metastatic disease was identified within sentinel lymph nodes. SLNs were most frequently located in the obturator and external iliac regions, with occasional upper pelvic and para-aortic drainage when lymphatic channels extended cranially. Lymphoedema occurred in 18 women (11.2 %) and was observed only in those who underwent pelvic lymphadenectomy.

Conclusions

This study describes long-term, real-world implementation of robotic ICG-guided SLN mapping in early-stage cervical cancer. The findings demonstrate consistent SLN detection, characteristic patterns of lymphatic drainage, and a lower observed incidence of lymphoedema when lymphadenectomy is avoided, supporting the role of SLN-guided nodal staging within contemporary, algorithm-based surgical practice.
目的描述机器人吲哚菁绿(ICG)引导前哨淋巴结(SLN)定位在早期宫颈癌淋巴结分期中的应用,并报告定位结果、SLN的解剖分布和围手术期发病率。方法:该单中心队列研究纳入了2015年至2025年期间接受机器人icg引导SLN测绘的早期宫颈癌女性。根据侧特异性算法进行盆腔淋巴结切除术或不进行盆腔淋巴结切除术的SLN定位。随着时间的推移,机构实践从常规的淋巴结转移定位和淋巴结切除术发展到选择性的单纯淋巴结转移分期。结果包括SLN的检出率、解剖分布、淋巴结转移和术后发病率。结果共161名女性接受了机器人SLN测绘。所有患者均实现SLN检测,145例(90.1%)患者双侧定位。16名妇女(9.9%)有淋巴结转移;所有转移性疾病均在前哨淋巴结内发现。sln最常位于闭孔区和髂外区,当淋巴通道向颅内延伸时,偶尔出现盆腔上部和主动脉旁引流。18名妇女(11.2%)发生淋巴水肿,仅在盆腔淋巴结切除术中观察到。本研究描述了机器人icg引导的SLN定位在早期宫颈癌中的长期、现实应用。研究结果表明,当避免行淋巴结切除术时,SLN的检测结果一致,淋巴引流的特征性模式,以及观察到的淋巴水肿发生率较低,这支持了SLN引导的淋巴结分期在当代基于算法的手术实践中的作用。
{"title":"Robotic indocyanine green-guided sentinel lymph node mapping in early-stage cervical cancer: The fluorescent robotic indocyanine endoscopic node detection series (FRIENDS)","authors":"Rahul Chatterjee ,&nbsp;Marielle Nobbenhuis ,&nbsp;Jenneke Kasius ,&nbsp;Manou Kaur ,&nbsp;Katherine Vroobel ,&nbsp;Ayoma Attygalle ,&nbsp;Thomas Edward James Ind","doi":"10.1016/j.ejogrb.2025.114927","DOIUrl":"10.1016/j.ejogrb.2025.114927","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the implementation of robotic indocyanine green (ICG)–guided sentinel lymph node (SLN) mapping for nodal staging in early-stage cervical cancer and to report mapping outcomes, anatomical distribution of SLNs, and perioperative morbidity.</div></div><div><h3>Methods</h3><div>This single-centre cohort study included women with presumed early-stage cervical cancer who underwent robotic ICG-guided SLN mapping between 2015 and 2025. SLN mapping was performed with or without pelvic lymphadenectomy according to a side-specific algorithm. Institutional practice evolved over time from routine SLN mapping with lymphadenectomy to selective SLN-only staging. Outcomes included SLN detection rates, anatomical distribution of SLNs, nodal metastases, and postoperative morbidity.</div></div><div><h3>Results</h3><div>A total of 161 women underwent robotic SLN mapping. SLN detection was achieved in all patients, with bilateral mapping in 145 (90.1 %). Sixteen women (9.9 %) had nodal metastases; all metastatic disease was identified within sentinel lymph nodes. SLNs were most frequently located in the obturator and external iliac regions, with occasional upper pelvic and <em>para</em>-aortic drainage when lymphatic channels extended cranially. Lymphoedema occurred in 18 women (11.2 %) and was observed only in those who underwent pelvic lymphadenectomy.</div></div><div><h3>Conclusions</h3><div>This study describes long-term, real-world implementation of robotic ICG-guided SLN mapping in early-stage cervical cancer. The findings demonstrate consistent SLN detection, characteristic patterns of lymphatic drainage, and a lower observed incidence of lymphoedema when lymphadenectomy is avoided, supporting the role of SLN-guided nodal staging within contemporary, algorithm-based surgical practice.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"318 ","pages":"Article 114927"},"PeriodicalIF":1.9,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145922009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developmental kinetics distinguish meiotic from mitotic chromosomal defects: Day-5 blastocyst achievement as age-independent predictor of euploid embryo yield 发育动力学区分减数分裂和有丝分裂染色体缺陷:第5天囊胚成就作为整倍体胚胎产量的年龄无关预测因子
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-02 DOI: 10.1016/j.ejogrb.2026.114935
Mai Vuong Hung , Pham Thi Hai Ha , Nguyen Khac Han Hoan , Nguyen Thanh Luan

Background

While maternal age is established as a dominant reproductive risk factor, the mechanistic distinction between age-dependent meiotic errors and age-independent mitotic errors remains uncharacterized. These divergent pathways have profound implications for patient counseling and treatment stratification but are rarely differentiated clinically.

Objectives

To establish distinct etiological pathways underlying chromosomal abnormalities by quantifying the differential age-sensitivity of whole-chromosome aneuploidies (meiotic origin) versus mosaic abnormalities (mitotic origin), determining whether developmental timing serves as an age-independent biomarker of genomic competence, and enabling practitioners to provide pathway-specific counseling and treatment recommendations.

Search strategy

PubMed, Embase, and ClinicalTrials.gov were searched for relevant studies.

Selection criteria

Retrospective cohort of 490 IVF patients (2,472 embryos) stratified by maternal age (≤35, 35–40, ≥40 years) with complete extended culture and next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy.

Data collection and analysis

Age-stratified analysis of developmental kinetics and comprehensive chromosomal classification. Multivariate logistic regression identified independent predictors of aneuploidy, adjusting for maternal age and day-5 blastocyst count.

Main results

Whole-chromosome aneuploidies demonstrated striking age-sensitivity (14.0 % to 36.5 %, 2.6-fold increase, p < 0.001), reflecting progressive cohesin complex degradation, spindle checkpoint decline, and mitochondrial bioenergetic insufficiency. Mosaicism remained age-independent (∼41 %, p = 0.383), arising from post-meiotic mitotic errors. Day-5 blastocyst formation declined 30 % with age (p = 0.0154), yet day-6 formation remained age-independent (p = 0.106), indicating developmental delay rather than failure. Day-5 blastocyst count independently protected against aneuploidy (OR 0.965, 95 % CI: 0.944–0.987, p = 0.002), persisting after multivariate adjustment.

Conclusions

Mechanistic differentiation between age-dependent meiotic and age-independent mitotic chromosomal abnormalities reveals fundamentally distinct etiological pathways with profound implications for clinical decision-making. In particular, day-5 blastocyst achievement emerges as an independent biomarker of oocyte quality, enabling precise within-age-group risk stratification regardless of chronological age. These findings translate developmental kinetics into quantitative clinical algorithms that substantially improve reproductive counseling accuracy and patient-specific prognostication beyond traditional age-based approaches.
虽然母亲年龄被确定为主要的生殖风险因素,但年龄依赖性减数分裂错误和年龄依赖性有丝分裂错误之间的机制区别仍未明确。这些不同的途径对患者的咨询和治疗分层有着深远的影响,但在临床上很少被区分。目的通过量化全染色体非整倍体(减数分裂起源)与mosaic异常(有丝分裂起源)的年龄敏感性差异,确定发育时间是否作为基因组能力的年龄独立生物标志物,并使从业者能够提供特定途径的咨询和治疗建议,从而建立染色体异常的独特病因学途径。检索pubmed、Embase和ClinicalTrials.gov等相关研究。选择标准:对490例体外受精患者(2472个胚胎)进行回顾性队列研究,按母亲年龄(≤35岁、35 - 40岁、≥40岁)分层,进行完全扩展培养和基于下一代测序(NGS)的非整倍体植入前基因检测。数据收集和分析发育动力学的分层分析和全面的染色体分类。多因素logistic回归确定了非整倍体的独立预测因素,调整了母亲年龄和第5天囊胚计数。主要结果全染色体非整倍体表现出显著的年龄敏感性(14.0% ~ 36.5%,增加2.6倍,p < 0.001),反映出黏结蛋白复合物的逐渐降解、纺锤体检查点下降和线粒体生物能量不足。镶嵌现象与年龄无关(~ 41%,p = 0.383),由减数分裂后的有丝分裂错误引起。第5天囊胚形成随年龄增长下降30% (p = 0.0154),而第6天囊胚形成与年龄无关(p = 0.106),表明发育迟缓而非发育失败。第5天囊胚计数独立保护非整倍体(OR 0.965, 95% CI: 0.944-0.987, p = 0.002),在多因素调整后持续存在。结论年龄依赖性减数分裂和年龄依赖性有丝分裂染色体异常的机制差异揭示了根本不同的病因途径,对临床决策具有重要意义。特别是,第5天囊胚发育成为卵母细胞质量的独立生物标志物,无论实际年龄如何,都可以精确地进行年龄组内风险分层。这些发现将发育动力学转化为定量临床算法,大大提高了生殖咨询的准确性和患者特异性预测,超越了传统的基于年龄的方法。
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引用次数: 0
The influence of discordant growth during pregnancy in dichorionic twins on adverse birth outcomes 双绒毛膜双胞胎妊娠期间生长不协调对不良出生结局的影响。
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-02 DOI: 10.1016/j.ejogrb.2026.114937
Shuang Ran , Xiaozhou Jia , Jun He , Tuanmei Wang , Donghua Xie , Xianglian Peng , Xingli Li

Objective

To investigate the influence of growth discordance in different trimesters of dichorionic twins on frequent adverse birth outcomes (preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA)).

Methods

Based on the Hunan Maternal and Child Health Hospital (HMCH) twin pregnancy cohort. Participants with dichorionic twin pregnancies who received prenatal care and delivered at HMCH between January 2019 and December 2024 were divided into four groups: whole-pregnancy concordant group (n = 428), isolated third-trimester discordant group (n = 30), isolated first-trimester discordant group (n = 35), and whole-pregnancy discordant group (n = 12). Grouping was based on whether first- and third-trimester fetal growth measured by ultrasound is concordant and tracking adverse birth outcomes in each group.

Results

Our study included 505 dichorionic twin pregnancies, with a maternal mean age of 30.97 ± 3.70 years. Compared to whole-pregnancy concordant group, isolated first-trimester discordant group did not have a higher risk of any adverse birth outcome (p ≥ 0.05), isolated third-trimester discordant group had a higher risk of SGA (RR = 3.48, 95 % CI: 2.38––5.10), and whole-pregnancy discordant group had a higher risk of both SGA and LBW (RR = 5.07, 95 % CI: 3.43–7.47; RR = 1.51, 95 % CI: 1.25–1.83). The risk of SGA and LBW was linearly correlated with the degree of growth discordance in the third trimester.

Conclusion

In dichorionic twin pregnancies, discordant growth in the first trimester does not increase the risk of adverse birth outcomes. The presence of discordant growth in the third trimester is the critical gestational period contributing to SGA and LBW. Therefore, it is essential to maintain growth concordance in dichorionic twins when entering the third trimester.
目的:探讨双绒毛膜双胞胎不同孕期生长发育不一致对常见不良出生结局(早产(PTB)、低出生体重(LBW)、小胎龄(SGA))的影响。方法:基于湖南省妇幼保健院(HMCH)双胎妊娠队列。在2019年1月至2024年12月期间接受产前护理并在HMCH分娩的双绒毛膜双胎妊娠参与者分为四组:全孕期和谐组(n = 428)、孤立的妊娠晚期不和谐组(n = 30)、孤立的妊娠早期不和谐组(n = 35)和全孕期不和谐组(n = 12)。分组是基于超声测量的妊娠早期和晚期胎儿生长是否一致,并跟踪每组的不良分娩结局。结果:本研究纳入双绒毛膜双胎妊娠505例,产妇平均年龄30.97±3.70岁。与全孕期一致组相比,孤立的妊娠早期不一致组没有更高的不良分娩结局风险(p≥0.05),孤立的妊娠晚期不一致组有更高的SGA风险(RR = 3.48, 95% CI: 2.38—5.10),妊娠晚期不一致组有更高的SGA和LBW风险(RR = 5.07, 95% CI: 3.43—7.47;RR = 1.51, 95% CI: 1.25—1.83)。妊娠晚期生长不协调程度与SGA和LBW风险呈线性相关。结论:在双绒毛膜双胎妊娠中,妊娠早期发育不一致不会增加不良分娩结局的风险。妊娠晚期出现不协调生长是导致SGA和LBW的关键妊娠期。因此,在进入妊娠晚期时,保持双绒毛膜双胞胎的生长一致性是至关重要的。
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引用次数: 0
Clinical and biological characteristics of dengue in pregnant women in Reunion Island: A nested case-control analysis in the EPIDENGUE cohort study 留尼旺岛孕妇登革热的临床和生物学特征:EPIDENGUE队列研究中的巢式病例对照分析
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01 DOI: 10.1016/j.ejogrb.2025.114932
Anne Cécilia Etoa Ndoko , Phuong Lien Tran , Marine Lafont , Yves Marie Diarra , Malik Boukerrou , Antoine Bertolotti , Patrick Gérardin

Introduction

Dengue is globally the most widespread arboviral disease, especially in tropical and subtropical regions. The primary aim of this study was to compare clinical and biological characteristics of dengue in pregnant and non-pregnant women on Reunion Island.

Methods

In the EPIDENGUE retrospective cohort conducted in University Hospital Center (CHU) of Saint Pierre, Réunion Island, between January 1, 2019, and June 30, 2019, we matched pregnant women (“PWG”, cases) and non-pregnant women (“NPWG”, controls) infected with dengue on age and identified the characteristics associated with dengue in pregnant women using a conditional logistic regression model.

Results

Among 274 female patients (median age 28.3 years) that were matched, patients in the PWG were more likely to develop pruritus (OR 5.18 [95 %CI 1.34–20.08] p = 0.017), less likely to experience anorexia (OR 0.19 [95 %CI 0.06–0.59] (p = 0.004), fever (OR 0.15 [95 %CI 0.04–0.65], p = 0.012), or to have a hematocrit of 38 % or above (OR 0.05 [95 %CI 0.01–0.22] p < 0.001) once controlled age, as compared to NPWG. We observed a non-significant trend towards a higher hematocrit level in women presenting warning signs (34.7 % vs 34.2 %, p = 0.084).

Conclusion

This nested case-control analysis highlights several clinical and-biological differences between pregnant and non-pregnant women with dengue, which are important to consider for avoiding the overdiagnosis of intrahepatic cholestasis of pregnancy and tailoring the monitoring of dengue in pregnant women. That implies screening for anorexia, fever and increase in hematocrit (prior to the decrease in platelet counts) as potential harbingers of progression to dengue with warning signs.
登革热是全球传播最广的虫媒病毒性疾病,特别是在热带和亚热带地区。本研究的主要目的是比较留尼旺岛孕妇和非孕妇登革热的临床和生物学特征。方法在2019年1月1日至2019年6月30日期间,在r union岛圣皮埃尔大学医院中心(CHU)进行EPIDENGUE回顾性队列研究,将感染登革热的孕妇(“PWG”,病例)和未感染登革热的孕妇(“NPWG”,对照组)按年龄进行匹配,并使用条件logistic回归模型确定孕妇登革热相关特征。结果在匹配的274例女性患者(中位年龄28.3岁)中,与NPWG组相比,PWG组患者在控制年龄后更容易出现瘙痒(OR 5.18 [95% CI 1.34-20.08] p = 0.017),更不容易出现厌食症(OR 0.19 [95% CI 0.06-0.59] (p = 0.004),发热(OR 0.15 [95% CI 0.04-0.65], p = 0.012),或红细胞压积在38%或以上(OR 0.05 [95% CI 0.01-0.22] p < 0.001)。我们观察到,在出现预警信号的女性中,红细胞压积水平升高的趋势不显著(34.7% vs 34.2%, p = 0.084)。结论巢式病例对照分析强调了妊娠期和非妊娠期登革热患者的临床和生物学差异,这对于避免妊娠期肝内胆汁淤积症的过度诊断和定制孕妇登革热监测具有重要意义。这意味着对厌食症、发热和红细胞压积增加(血小板计数下降之前)进行筛查,将其作为有警告信号的登革热进展的潜在前兆。
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引用次数: 0
Expression of concern “Abdominal electromyography may predict the response to tocolysis in preterm labor”. [Eur. J. Obstet. Gynecol. Reprod. Biol. 160/1 (2012) 18–21] 关注的表达“腹部肌电图可以预测早产儿对缩胎的反应”。(欧元。j .。。Gynecol。天线转换开关。生物学报,160/1 (2012)18-21 [j]
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01
Mohamed A. Kandil, Mehany M. Abdel-Sattar, Sherif M. Abdel-Salam, SaidA. Saleh, Mohamed M. Khalafallah
{"title":"Expression of concern “Abdominal electromyography may predict the response to tocolysis in preterm labor”. [Eur. J. Obstet. Gynecol. Reprod. Biol. 160/1 (2012) 18–21]","authors":"Mohamed A. Kandil,&nbsp;Mehany M. Abdel-Sattar,&nbsp;Sherif M. Abdel-Salam,&nbsp;SaidA. Saleh,&nbsp;Mohamed M. Khalafallah","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"319 ","pages":"Article 114970"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146076469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of concern “Bacterial vaginosis and infertility: cause or association?” [Eur. J. Obstet. Gynecol. Reprod. Biol. 167/1 (2013) 59–63] 关注表达“细菌性阴道病与不孕症:原因还是关联?”(欧元。j .。。Gynecol。天线转换开关。生物学报,167/1 (2013)59-63]
IF 1.9 4区 医学 Q2 OBSTETRICS & GYNECOLOGY Pub Date : 2026-01-01
Rasheed M. Salah , Abdelmonem M. Allam , Amin M. Magdy , Abeer Sh. Mohamed
{"title":"Expression of concern “Bacterial vaginosis and infertility: cause or association?” [Eur. J. Obstet. Gynecol. Reprod. Biol. 167/1 (2013) 59–63]","authors":"Rasheed M. Salah ,&nbsp;Abdelmonem M. Allam ,&nbsp;Amin M. Magdy ,&nbsp;Abeer Sh. Mohamed","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"318 ","pages":"Article 114934"},"PeriodicalIF":1.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146022744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
European journal of obstetrics, gynecology, and reproductive biology
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