European journal of obstetrics, gynecology, and reproductive biology最新文献

英文中文

The influence of discordant growth during pregnancy in dichorionic twins on adverse birth outcomes 双绒毛膜双胞胎妊娠期间生长不协调对不良出生结局的影响。

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2026-01-02 DOI: 10.1016/j.ejogrb.2026.114937

Shuang Ran , Xiaozhou Jia , Jun He , Tuanmei Wang , Donghua Xie , Xianglian Peng , Xingli Li

Objective

To investigate the influence of growth discordance in different trimesters of dichorionic twins on frequent adverse birth outcomes (preterm birth (PTB), low birth weight (LBW), and small for gestational age (SGA)).

Methods

Based on the Hunan Maternal and Child Health Hospital (HMCH) twin pregnancy cohort. Participants with dichorionic twin pregnancies who received prenatal care and delivered at HMCH between January 2019 and December 2024 were divided into four groups: whole-pregnancy concordant group (n = 428), isolated third-trimester discordant group (n = 30), isolated first-trimester discordant group (n = 35), and whole-pregnancy discordant group (n = 12). Grouping was based on whether first- and third-trimester fetal growth measured by ultrasound is concordant and tracking adverse birth outcomes in each group.

Results

Our study included 505 dichorionic twin pregnancies, with a maternal mean age of 30.97 ± 3.70 years. Compared to whole-pregnancy concordant group, isolated first-trimester discordant group did not have a higher risk of any adverse birth outcome (p ≥ 0.05), isolated third-trimester discordant group had a higher risk of SGA (RR = 3.48, 95 % CI: 2.38––5.10), and whole-pregnancy discordant group had a higher risk of both SGA and LBW (RR = 5.07, 95 % CI: 3.43–7.47; RR = 1.51, 95 % CI: 1.25–1.83). The risk of SGA and LBW was linearly correlated with the degree of growth discordance in the third trimester.

Conclusion

In dichorionic twin pregnancies, discordant growth in the first trimester does not increase the risk of adverse birth outcomes. The presence of discordant growth in the third trimester is the critical gestational period contributing to SGA and LBW. Therefore, it is essential to maintain growth concordance in dichorionic twins when entering the third trimester.

目的：探讨双绒毛膜双胞胎不同孕期生长发育不一致对常见不良出生结局（早产（PTB）、低出生体重（LBW）、小胎龄（SGA））的影响。方法：基于湖南省妇幼保健院（HMCH）双胎妊娠队列。在2019年1月至2024年12月期间接受产前护理并在HMCH分娩的双绒毛膜双胎妊娠参与者分为四组：全孕期和谐组（n = 428）、孤立的妊娠晚期不和谐组（n = 30）、孤立的妊娠早期不和谐组（n = 35）和全孕期不和谐组（n = 12）。分组是基于超声测量的妊娠早期和晚期胎儿生长是否一致，并跟踪每组的不良分娩结局。结果：本研究纳入双绒毛膜双胎妊娠505例，产妇平均年龄30.97±3.70岁。与全孕期一致组相比，孤立的妊娠早期不一致组没有更高的不良分娩结局风险（p≥0.05），孤立的妊娠晚期不一致组有更高的SGA风险（RR = 3.48, 95% CI: 2.38—5.10），妊娠晚期不一致组有更高的SGA和LBW风险（RR = 5.07, 95% CI: 3.43—7.47;RR = 1.51, 95% CI: 1.25—1.83）。妊娠晚期生长不协调程度与SGA和LBW风险呈线性相关。结论：在双绒毛膜双胎妊娠中，妊娠早期发育不一致不会增加不良分娩结局的风险。妊娠晚期出现不协调生长是导致SGA和LBW的关键妊娠期。因此，在进入妊娠晚期时，保持双绒毛膜双胞胎的生长一致性是至关重要的。

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引用次数: 0

Clinical and biological characteristics of dengue in pregnant women in Reunion Island: A nested case-control analysis in the EPIDENGUE cohort study 留尼旺岛孕妇登革热的临床和生物学特征：EPIDENGUE队列研究中的巢式病例对照分析

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2026-01-01 DOI: 10.1016/j.ejogrb.2025.114932

Anne Cécilia Etoa Ndoko , Phuong Lien Tran , Marine Lafont , Yves Marie Diarra , Malik Boukerrou , Antoine Bertolotti , Patrick Gérardin

Introduction

Dengue is globally the most widespread arboviral disease, especially in tropical and subtropical regions. The primary aim of this study was to compare clinical and biological characteristics of dengue in pregnant and non-pregnant women on Reunion Island.

Methods

In the EPIDENGUE retrospective cohort conducted in University Hospital Center (CHU) of Saint Pierre, Réunion Island, between January 1, 2019, and June 30, 2019, we matched pregnant women (“PWG”, cases) and non-pregnant women (“NPWG”, controls) infected with dengue on age and identified the characteristics associated with dengue in pregnant women using a conditional logistic regression model.

Results

Among 274 female patients (median age 28.3 years) that were matched, patients in the PWG were more likely to develop pruritus (OR 5.18 [95 %CI 1.34–20.08] p = 0.017), less likely to experience anorexia (OR 0.19 [95 %CI 0.06–0.59] (p = 0.004), fever (OR 0.15 [95 %CI 0.04–0.65], p = 0.012), or to have a hematocrit of 38 % or above (OR 0.05 [95 %CI 0.01–0.22] p < 0.001) once controlled age, as compared to NPWG. We observed a non-significant trend towards a higher hematocrit level in women presenting warning signs (34.7 % vs 34.2 %, p = 0.084).

Conclusion

This nested case-control analysis highlights several clinical and-biological differences between pregnant and non-pregnant women with dengue, which are important to consider for avoiding the overdiagnosis of intrahepatic cholestasis of pregnancy and tailoring the monitoring of dengue in pregnant women. That implies screening for anorexia, fever and increase in hematocrit (prior to the decrease in platelet counts) as potential harbingers of progression to dengue with warning signs.

登革热是全球传播最广的虫媒病毒性疾病，特别是在热带和亚热带地区。本研究的主要目的是比较留尼旺岛孕妇和非孕妇登革热的临床和生物学特征。方法在2019年1月1日至2019年6月30日期间，在r union岛圣皮埃尔大学医院中心（CHU）进行EPIDENGUE回顾性队列研究，将感染登革热的孕妇（“PWG”，病例）和未感染登革热的孕妇（“NPWG”，对照组）按年龄进行匹配，并使用条件logistic回归模型确定孕妇登革热相关特征。结果在匹配的274例女性患者（中位年龄28.3岁）中，与NPWG组相比，PWG组患者在控制年龄后更容易出现瘙痒（OR 5.18 [95% CI 1.34-20.08] p = 0.017），更不容易出现厌食症(OR 0.19 [95% CI 0.06-0.59] (p = 0.004)，发热（OR 0.15 [95% CI 0.04-0.65], p = 0.012），或红细胞压积在38%或以上（OR 0.05 [95% CI 0.01-0.22] p < 0.001）。我们观察到，在出现预警信号的女性中，红细胞压积水平升高的趋势不显著（34.7% vs 34.2%, p = 0.084）。结论巢式病例对照分析强调了妊娠期和非妊娠期登革热患者的临床和生物学差异，这对于避免妊娠期肝内胆汁淤积症的过度诊断和定制孕妇登革热监测具有重要意义。这意味着对厌食症、发热和红细胞压积增加（血小板计数下降之前）进行筛查，将其作为有警告信号的登革热进展的潜在前兆。

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引用次数: 0

Expression of concern “Abdominal electromyography may predict the response to tocolysis in preterm labor”. [Eur. J. Obstet. Gynecol. Reprod. Biol. 160/1 (2012) 18–21] 关注的表达“腹部肌电图可以预测早产儿对缩胎的反应”。(欧元。j .。。Gynecol。天线转换开关。生物学报，160/1 (2012)18-21 [j]

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2026-01-01

Mohamed A. Kandil, Mehany M. Abdel-Sattar, Sherif M. Abdel-Salam, SaidA. Saleh, Mohamed M. Khalafallah

引用次数: 0

Expression of concern “Bacterial vaginosis and infertility: cause or association?” [Eur. J. Obstet. Gynecol. Reprod. Biol. 167/1 (2013) 59–63] 关注表达“细菌性阴道病与不孕症：原因还是关联？”(欧元。j .。。Gynecol。天线转换开关。生物学报，167/1 (2013)59-63]

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2026-01-01

Rasheed M. Salah , Abdelmonem M. Allam , Amin M. Magdy , Abeer Sh. Mohamed

引用次数: 0

Expression of concern “Maternal and neonatal copeptin levels at caesarean section and vaginal delivery”. [Eur. J. Obstet. Gynecol. Reprod. Biol. 165/2 (2012) 215–218] 关注表达“剖腹产和阴道分娩时产妇和新生儿copeptin水平”。(欧元。j .。。Gynecol。天线转换开关。生物学报，165/2 (2012)215-218]

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2026-01-01

Ashraf A. Foda , Ibrahim A. Abdel Aal

引用次数: 0

Expression of concern: “Is dienogest a convenient treatment option for cesarean scar endometriosis or should it be treated surgically?”. [Eur. J. Obstet. Gynecol. Reprod. Biol. 282 (2023) 110–115] 关注表达：“对于剖宫产瘢痕子宫内膜异位症，dienogest是一种方便的治疗选择，还是应该进行手术治疗？”(欧元。j .。。Gynecol。天线转换开关。生物学报。282 (2023)110-115]

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2026-01-01

Kerem Doga Seckin , Pinar Kadirogullari

引用次数: 0

Expression of concern “A randomized comparison of a single-incision needleless (Contasure-needleless®) mini-sling versus a mid-urethral sling (Contasure-KIM®): 60-month follow-up results”. [Eur. J. Obstet. Gynecol. Reprod. Biol. 307C (2025) 7–12] “单切口无针（contasure - needeless®）迷你吊带与中尿道吊带（Contasure-KIM®）的随机比较：60个月的随访结果”。(欧元。j .。。Gynecol。天线转换开关。生物学报。307C (2025) 7-12]

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2026-01-01

Ozan Dogan , Pinar Kadirogullari , Erhan Huseyin Comert , Alper Basbug , Murat Yassa

引用次数: 0

Value of triglyceride-glucose index in diagnosis of gestational diabetes mellitus: a systematic review and meta-analysis 甘油三酯-葡萄糖指数在妊娠期糖尿病诊断中的价值：系统回顾和荟萃分析

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2025-12-31 DOI: 10.1016/j.ejogrb.2025.114931

Binze Chen , Teng Ma , Ying Liu , Mengting Wang , Tingting Yin , Yanxia Han

Purpose

To assess the accuracy of triglyceride-glucose index (TyG) in the diagnosis of gestational diabetes mellitus (GDM).

Methods

Embase, Cochrane Library, PubMed, and Web of Science were searched up to April 18, 2025 for English-language clinical studies using TyG for GDM prediction. The Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool was utilized for quality assessment, and the final results were presented by RevMan5.3. The overall accuracy of TyG in GDM diagnosis was identified using Stata15.0 and Meta-DiSc1.4. We also performed subgroup analyses by the sample size, prevalence, cutoff, and trimester of pregnancy.

Results

Sixteen studies with 480,402 participants were included. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio of TyG in GDM diagnosis were 0.63 (95 % CI 0.56–0.70), 0.64 (95 % CI 0.60–0.68), 1.80 (95 % CI 1.60–1.90), 0.57 (95 % CI 0.49–0.67), and 3.00 (95 % CI 2.00–4.00), respectively. The area under the summary receiver operating characteristic (SROC) curve of TyG was 0.68 (95 % CI 0.64–0.72). Subgroup analyses revealed that small sample sizes, high prevalence, cutoff < 8.5, and the second trimester corresponded to the high accuracy of TyG in GDM diagnosis.

Conclusion

TyG demonstrates moderate diagnostic accuracy for GDM, with an area under the SROC curve of 0.68. Considering the limitations of the available studies, more prospective studies are still required to clarify the diagnostic value of TyG in actual clinical practice and offer a stronger basis for clinical decision-making.

目的探讨甘油三酯-葡萄糖指数（TyG）在妊娠期糖尿病（GDM）诊断中的准确性。方法检索sembase、Cochrane Library、PubMed和Web of Science，检索截至2025年4月18日使用TyG预测GDM的英文临床研究。采用诊断准确性研究质量评估-2 （QUADAS-2）工具进行质量评估，最终结果由RevMan5.3给出。使用Stata15.0和Meta-DiSc1.4确定TyG在GDM诊断中的总体准确性。我们还根据样本量、患病率、截止时间和妊娠三个月进行了亚组分析。结果共纳入16项研究，480402名受试者。TyG在GDM诊断中的敏感性、特异性、阳性似然比、阴性似然比、诊断优势比分别为0.63 （95% CI 0.56 ~ 0.70）、0.64 （95% CI 0.60 ~ 0.68）、1.80 （95% CI 1.60 ~ 1.90）、0.57 （95% CI 0.49 ~ 0.67）、3.00 （95% CI 2.00 ~ 4.00）。TyG的综合受试者工作特征（SROC）曲线下面积为0.68 （95% CI 0.64 ~ 0.72）。亚组分析显示，样本量小、患病率高、临界值<； 8.5、妊娠中期与TyG在GDM诊断中的准确性较高相对应。结论tyg对GDM的诊断准确率中等，SROC曲线下面积为0.68。考虑到现有研究的局限性，仍需要更多的前瞻性研究来明确TyG在实际临床中的诊断价值，为临床决策提供更有力的依据。

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引用次数: 0

Development and preliminary evaluation of a machine learning model for predicting low birth weight using placental IVIM-MRI and maternal clinical characteristics 利用胎盘IVIM-MRI和产妇临床特征预测低出生体重的机器学习模型的开发和初步评估

IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2025-12-31 DOI: 10.1016/j.ejogrb.2025.114930

Wei Bian, Wenting Zhang, Hui Liu, Linping Wang, Fang Wei, Yuan Yao

Objective

To identify key placental intravoxel incoherent motion (IVIM) MRI parameters and maternal factors associated with low birth weight (LBW), and develop a prenatal predictive model for LBW risk assessment.

Methods

This retrospective study analyzed 113 term neonates (January 2023–December 2024), categorized as LBW or normal birth weight. Twenty-one antenatal metrics, including maternal characteristics and region-specific placental IVIM MRI parameters (perfusion fraction [f], true diffusion coefficient [D], pseudo-diffusion coefficient [D*]), were evaluated. Feature importance was ranked using Shapley Additive Explanations (SHAP) analysis in a Random Forest algorithm. Key predictors were used to build a multivariable logistic regression nomogram. Discrimination (ROC-AUC), calibration, and clinical utility (DCA) were assessed. Internal validation employed bootstrap resampling (1000 iterations).

Results

SHAP identified f values from maximal placental section (f_MPS), central zone (f_CPZ), and fetal side (f_FS) as top predictors. The nomogram showed good discrimination (AUC = 0.86, 95 % CI: 0.74–0.98). Bootstrap validation yielded an AUC of 0.82 (95 % CI: 0.61–0.98), with high sensitivity and specificity. The calibration curve showed good model fit. DCA demonstrated considerable clinical benefit.

Conclusion

Placental IVIM MRI f values from distinct placental regions are significant LBW predictors. The model provides accurate prenatal risk assessment, guiding early interventions to optimize perinatal outcomes.

目的探讨胎盘体素内不相干运动（IVIM） MRI关键参数及与低出生体重（LBW）相关的母体因素，建立低出生体重风险评估的产前预测模型。方法回顾性分析2013年1月~ 2024年12月113例足月新生儿，均为低体重或正常出生体重。评估21项产前指标，包括产妇特征和区域特异性胎盘IVIM MRI参数（灌注分数[f]、真扩散系数[D]、伪扩散系数[D*]）。使用随机森林算法中的Shapley加性解释（SHAP）分析对特征重要性进行排序。使用关键预测因子构建多变量logistic回归nomogram。评估辨别（ROC-AUC）、校准和临床效用（DCA）。内部验证采用自举重采样（1000次迭代）。结果shap确定最大胎盘切片（f_MPS）、中心区（f_CPZ）和胎儿侧（f_FS）的f值为预测因子。模态图具有良好的鉴别性（AUC = 0.86, 95% CI: 0.74 ~ 0.98）。Bootstrap验证的AUC为0.82 (95% CI: 0.61-0.98)，具有较高的灵敏度和特异性。标定曲线模型拟合良好。DCA显示出相当大的临床益处。结论不同胎盘区域的胎盘IVIM MRI f值是预测LBW的重要指标。该模型提供准确的产前风险评估，指导早期干预以优化围产期结局。

{"title":"Development and preliminary evaluation of a machine learning model for predicting low birth weight using placental IVIM-MRI and maternal clinical characteristics","authors":"Wei Bian, Wenting Zhang, Hui Liu, Linping Wang, Fang Wei, Yuan Yao","doi":"10.1016/j.ejogrb.2025.114930","DOIUrl":"10.1016/j.ejogrb.2025.114930","url":null,"abstract":"<div><h3>Objective</h3><div>To identify key placental intravoxel incoherent motion (IVIM) MRI parameters and maternal factors associated with low birth weight (LBW), and develop a prenatal predictive model for LBW risk assessment.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed 113 term neonates (January 2023–December 2024), categorized as LBW or normal birth weight. Twenty-one antenatal metrics, including maternal characteristics and region-specific placental IVIM MRI parameters (perfusion fraction [f], true diffusion coefficient [D], pseudo-diffusion coefficient [D*]), were evaluated. Feature importance was ranked using Shapley Additive Explanations (SHAP) analysis in a Random Forest algorithm. Key predictors were used to build a multivariable logistic regression nomogram. Discrimination (ROC-AUC), calibration, and clinical utility (DCA) were assessed. Internal validation employed bootstrap resampling (1000 iterations).</div></div><div><h3>Results</h3><div>SHAP identified f values from maximal placental section (f_MPS), central zone (f_CPZ), and fetal side (f_FS) as top predictors. The nomogram showed good discrimination (AUC = 0.86, 95 % CI: 0.74–0.98). Bootstrap validation yielded an AUC of 0.82 (95 % CI: 0.61–0.98), with high sensitivity and specificity. The calibration curve showed good model fit. DCA demonstrated considerable clinical benefit.</div></div><div><h3>Conclusion</h3><div>Placental IVIM MRI f values from distinct placental regions are significant LBW predictors. The model provides accurate prenatal risk assessment, guiding early interventions to optimize perinatal outcomes.</div></div>","PeriodicalId":11975,"journal":{"name":"European journal of obstetrics, gynecology, and reproductive biology","volume":"318 ","pages":"Article 114930"},"PeriodicalIF":1.9,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145881266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 1.9 4区医学 Q2 OBSTETRICS & GYNECOLOGY

European journal of obstetrics, gynecology, and reproductive biology

Pub Date : 2025-12-30 DOI: 10.1016/S0301-2115(25)01194-7

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