首页 > 最新文献

European Journal of Lipid Science and Technology最新文献

英文 中文
Soybean Oil, Linseed Oil, Brazil Nut Oil and Fish Oil Supplementation in European Quails Diet: Lipid and Protein Oxidative Stability of Meat During Storage 欧洲鹌鹑日粮中添加大豆油、亚麻籽油、巴西坚果油和鱼油:贮藏期间肉的脂质和蛋白质氧化稳定性
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-10-31 DOI: 10.1002/ejlt.70076
Janiele Ferreira da Silva, Cristiani Viegas Brandão Grisi, Cecylyana Leite Cavalcante, Valquíria Cardoso Da Silva Ferreira, Bruno Raniere Lins de Albuquerque Meireles, José Jordão Filho, Leonardo Augusto Fonseca Pascoal

The objective of this study was to evaluate the oxidative stability of quail (Coturnix coturnix) meat fed with different lipid sources during storage (0, 30, and 60 days) under freezing conditions at −18°C. The lipid sources used in the diet of birds were soybean oil (SO), linseed oil (LO), Brazil nut oil (BN), fish oil (FO), and three other mixes composed of 1% BN + 1% SO 1%, 1% LO +1% SO, and 1% FO+ 1% SO. The breast meat of quails was evaluated for color parameters (L*, a*, and b*), peroxide index, thiobarbituric acid reactive substances (TBARS), warmed-over flavor analysis (WOF), and quantification of carbonyl compounds during storage. There was a decline in the luminosity (L*) and redness (a*) values of quail meat during storage. Peroxide and TBARS levels increased over time. The WOF and carbonyl compounds showed reduced values at the end of storage. Through principal component analysis, it was observed that the parameters of L*, TBARS, and WOF were more relevant in this study. Therefore, the meat of quails fed with diets enriched with BN, either alone or together with SO, showed the ability to slow down the oxidation process.

Practical Applications: These results have practical applicability for birds and the industry of the quail. Brazil nut oil was responsible for preserving the redness during storage. Brazil nut oil minimized the effects of lipid oxidation during the storage period.

本研究的目的是在- 18°C的冷冻条件下,评估饲喂不同脂质来源的鹌鹑肉(Coturnix Coturnix)在储存(0,30和60天)期间的氧化稳定性。鸟饲粮中的脂质来源为大豆油(SO)、亚麻籽油(LO)、巴西坚果油(BN)、鱼油(FO)和另外3种由1% BN +1% SO 1%、1% LO +1% SO和1% FO+ 1% SO组成的混合物。对鹌鹑胸肉的颜色参数(L*、a*和b*)、过氧化物指数、硫代巴比妥酸活性物质(TBARS)、热过味分析(WOF)和储存过程中羰基化合物的定量进行了评价。鹌鹑肉的光度(L*)和红度(a*)值在贮藏过程中呈下降趋势。过氧化氢和TBARS水平随着时间的推移而增加。WOF和羰基化合物在贮藏结束时呈下降趋势。通过主成分分析发现,本研究中L*、TBARS和WOF参数相关性更强。因此,饲喂富含BN的鹌鹑肉,无论是单独饲养还是与SO一起饲养,都显示出减缓氧化过程的能力。实际应用:这些结果对鸟类和鹌鹑业具有实际的适用性。巴西坚果油负责在储存期间保持红色。巴西坚果油在储存期间最大限度地减少了脂质氧化的影响。
{"title":"Soybean Oil, Linseed Oil, Brazil Nut Oil and Fish Oil Supplementation in European Quails Diet: Lipid and Protein Oxidative Stability of Meat During Storage","authors":"Janiele Ferreira da Silva,&nbsp;Cristiani Viegas Brandão Grisi,&nbsp;Cecylyana Leite Cavalcante,&nbsp;Valquíria Cardoso Da Silva Ferreira,&nbsp;Bruno Raniere Lins de Albuquerque Meireles,&nbsp;José Jordão Filho,&nbsp;Leonardo Augusto Fonseca Pascoal","doi":"10.1002/ejlt.70076","DOIUrl":"https://doi.org/10.1002/ejlt.70076","url":null,"abstract":"<p>The objective of this study was to evaluate the oxidative stability of quail (<i>Coturnix coturnix</i>) meat fed with different lipid sources during storage (0, 30, and 60 days) under freezing conditions at −18°C. The lipid sources used in the diet of birds were soybean oil (SO), linseed oil (LO), Brazil nut oil (BN), fish oil (FO), and three other mixes composed of 1% BN + 1% SO 1%, 1% LO +1% SO, and 1% FO+ 1% SO. The breast meat of quails was evaluated for color parameters (<i>L</i>*, <i>a</i>*, and <i>b</i>*), peroxide index, thiobarbituric acid reactive substances (TBARS), warmed-over flavor analysis (WOF), and quantification of carbonyl compounds during storage. There was a decline in the luminosity (<i>L</i>*) and redness (<i>a</i>*) values of quail meat during storage. Peroxide and TBARS levels increased over time. The WOF and carbonyl compounds showed reduced values at the end of storage. Through principal component analysis, it was observed that the parameters of <i>L</i>*, TBARS, and WOF were more relevant in this study. Therefore, the meat of quails fed with diets enriched with BN, either alone or together with SO, showed the ability to slow down the oxidation process.</p><p><i>Practical Applications</i>: These results have practical applicability for birds and the industry of the quail. Brazil nut oil was responsible for preserving the redness during storage. Brazil nut oil minimized the effects of lipid oxidation during the storage period.</p>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"128 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejlt.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146007689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining Partial Hydrogenation of Soybean-Derived Biodiesel and Methoxycarbonylation Using a Single Palladium Source 大豆生物柴油部分加氢与单一钯源甲氧羰基化的结合
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-10-24 DOI: 10.1002/ejlt.70073
Florian Lehmann, Hannes W. Wegener, Nils Brede, Thomas Seidensticker

Valorization of soybean-derived biodiesel through an integrated tandem one-pot approach was examined. Recent studies have indicated the necessity of pretreating unsaturated fatty acid methyl esters (FAMEs) to remove polyunsaturated FAME (PU-FAME), due to their inhibitory effect on various homogeneous catalyzed reactions. The first step in the process under investigation involves the selective partial hydrogenation of PU-FAME towards monounsaturated FAME (MU-FAME), catalyzed by palladium nanoparticles in methanol. This is followed by the Pd/1,2-bis[(di-tert-butylphosphino)methyl]benzene (1,2-DTBPMB)-catalyzed isomerizing methoxycarbonylation (iMC) of MU-FAME, resulting in a linear C19-diester. Utilizing the protonated derivative of the 1,2-DTBPMB ligand for the iMC, the Pd nanoparticles employed in the hydrogenation step function as a catalyst precursor. The combination of both reactions in a tandem one-pot approach would eliminate the need for a work-up, thereby streamlining the process. However, the process is hindered by several challenges arising from the contrary optimal operating conditions for both reactions, such as the selection of solvent, the amount of catalyst, and the presence of the accompanying gas in the reaction mixture. These aspects have been thoroughly examined in this study, leading to the development of an optimized reaction workflow. Utilizing this method, the partial hydrogenation of soybean FAME is achieved with conversions of 95%–98%, followed by the in situ formation of the homogeneous catalyst and the iMC, yielding a linear C19-diester with a selectivity of 98%.

Practical Applications: This study proposes a novel integrated tandem one-pot approach for the selective partial hydrogenation of vegetable FAME to MU-FAME, followed by the homogeneously catalyzed iMC. The integration of Pd nanoparticles as both a catalyst for hydrogenation and as a precursor for the formation of a homogeneous catalyst utilized in iMC ensures the efficient utilization of the metal throughout the whole reaction sequence. The method integrates the necessary pretreatment with sequential functionalization under optimized conditions.

通过集成串联一锅法研究了大豆生物柴油的增值。由于多不饱和脂肪酸甲酯(PU-FAME)对多种均相催化反应有抑制作用,近年来的研究表明有必要对其进行预处理以去除多不饱和脂肪酸甲酯(FAMEs)。研究过程的第一步是在甲醇中钯纳米粒子催化下,将PU-FAME选择性部分加氢成单不饱和FAME (MU-FAME)。随后Pd/1,2-二[(二叔丁基膦基)甲基]苯(1,2- dtbpmb)催化MU-FAME的异构化甲氧羰基化(iMC),生成线性c19 -二酯。利用1,2- dtbpmb配体的质子化衍生物,在加氢步骤中使用的Pd纳米颗粒作为催化剂前驱体。将两种反应结合在一个串联的一锅方法中,将消除对后续处理的需要,从而简化了过程。然而,由于两种反应的最佳操作条件相反,例如溶剂的选择、催化剂的用量以及反应混合物中伴生气体的存在,这一过程受到了一些挑战的阻碍。本研究对这些方面进行了全面的研究,从而开发了优化的反应工作流程。利用该方法,大豆FAME的部分加氢转化率为95%-98%,然后原位生成均相催化剂和iMC,得到选择性为98%的线性c19 -二酯。实际应用:本研究提出了一种新的集成串联一锅方法,用于蔬菜FAME选择性部分加氢制备MU-FAME,然后均匀催化iMC。钯纳米颗粒作为氢化催化剂和形成均相催化剂的前驱体,在iMC中使用,确保了金属在整个反应过程中的有效利用。该方法将必要的预处理与优化条件下的顺序泛函化相结合。
{"title":"Combining Partial Hydrogenation of Soybean-Derived Biodiesel and Methoxycarbonylation Using a Single Palladium Source","authors":"Florian Lehmann,&nbsp;Hannes W. Wegener,&nbsp;Nils Brede,&nbsp;Thomas Seidensticker","doi":"10.1002/ejlt.70073","DOIUrl":"https://doi.org/10.1002/ejlt.70073","url":null,"abstract":"<p>Valorization of soybean-derived biodiesel through an integrated tandem one-pot approach was examined. Recent studies have indicated the necessity of pretreating unsaturated fatty acid methyl esters (FAMEs) to remove polyunsaturated FAME (PU-FAME), due to their inhibitory effect on various homogeneous catalyzed reactions. The first step in the process under investigation involves the selective partial hydrogenation of PU-FAME towards monounsaturated FAME (MU-FAME), catalyzed by palladium nanoparticles in methanol. This is followed by the Pd/1,2-bis[(di-<i>tert</i>-butylphosphino)methyl]benzene (1,2-DTBPMB)-catalyzed isomerizing methoxycarbonylation (iMC) of MU-FAME, resulting in a linear C<sub>19</sub>-diester. Utilizing the protonated derivative of the 1,2-DTBPMB ligand for the iMC, the Pd nanoparticles employed in the hydrogenation step function as a catalyst precursor. The combination of both reactions in a tandem one-pot approach would eliminate the need for a work-up, thereby streamlining the process. However, the process is hindered by several challenges arising from the contrary optimal operating conditions for both reactions, such as the selection of solvent, the amount of catalyst, and the presence of the accompanying gas in the reaction mixture. These aspects have been thoroughly examined in this study, leading to the development of an optimized reaction workflow. Utilizing this method, the partial hydrogenation of soybean FAME is achieved with conversions of 95%–98%, followed by the in situ formation of the homogeneous catalyst and the iMC, yielding a linear C<sub>19</sub>-diester with a selectivity of 98%.</p><p><i>Practical Applications</i>: This study proposes a novel integrated tandem one-pot approach for the selective partial hydrogenation of vegetable FAME to MU-FAME, followed by the homogeneously catalyzed iMC. The integration of Pd nanoparticles as both a catalyst for hydrogenation and as a precursor for the formation of a homogeneous catalyst utilized in iMC ensures the efficient utilization of the metal throughout the whole reaction sequence. The method integrates the necessary pretreatment with sequential functionalization under optimized conditions.</p>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 11","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejlt.70073","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145522409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: Eur. J. Lipid Sci. Technol. 发行信息:欧元。J.油脂科学。抛光工艺。
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-10-15 DOI: 10.1002/ejlt.70074
{"title":"Issue Information: Eur. J. Lipid Sci. Technol.","authors":"","doi":"10.1002/ejlt.70074","DOIUrl":"https://doi.org/10.1002/ejlt.70074","url":null,"abstract":"","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejlt.70074","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145296921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzymatic Valorization of Fatty Acids in Oleochemical Synthesis 油脂化学合成中脂肪酸的酶促增值
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-10-09 DOI: 10.1002/ejlt.70070
Florian Tieves, Frank Hollmann

The following article for this Special Issue was published in an earlier Issue.

F. Tieves and F. Hollmann, “Enzymatic Valorization of Fatty Acids in Oleochemical Synthesis,” European Journal of Lipid Science and Technology 127 (2025): e70000. https://doi.org/10.1002/ejlt.70000. https://onlinelibrary.wiley.com/doi/10.1002/ejlt.70000

本特刊的以下文章发表在以前的一期上。F. Tieves和F. Hollmann,“脂肪酸在油脂化学合成中的酶促价值”,欧洲脂质科学与技术杂志127 (2025):e70000。https://doi.org/10.1002/ejlt.70000。https://onlinelibrary.wiley.com/doi/10.1002/ejlt.70000
{"title":"Enzymatic Valorization of Fatty Acids in Oleochemical Synthesis","authors":"Florian Tieves,&nbsp;Frank Hollmann","doi":"10.1002/ejlt.70070","DOIUrl":"https://doi.org/10.1002/ejlt.70070","url":null,"abstract":"<div>\u0000 \u0000 <p><b>The following article for this Special Issue was published in an earlier Issue</b>.</p>\u0000 <p>F. Tieves and F. Hollmann, “Enzymatic Valorization of Fatty Acids in Oleochemical Synthesis,” <i>European Journal of Lipid Science and Technology</i> <i>127</i> (2025): e70000. https://doi.org/10.1002/ejlt.70000. https://onlinelibrary.wiley.com/doi/10.1002/ejlt.70000</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 7","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Beeswax on the Stability of W/O Emulsion and Its Mechanism 蜂蜡对水乳状液稳定性的影响及其机理
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-09-22 DOI: 10.1002/ejlt.70072
Qianjie Zhang, HaoYue Ying, ZeDong Zheng, Liang Zhuang, Zijia Zhang, Wanping Zhang

Wax-containing water-in-oil (W/O) emulsions are widely used in industries such as food, pharmaceuticals, and petroleum. However, waxy materials pose challenges to the stability of emulsions. This study investigated the relationship between beeswax (BW) crystallization behavior and W/O emulsion stability in five different oil systems: straight-chain alkanes, esters, branched-chain alkanes, and triglycerides. EM90 was chosen as an emulsifier. Results showed that BW crystallization behavior depended on its compatibility with emulsifiers and oils, directly impacting the stability of the emulsion. Specifically, in alkanes, poor compatibility with undecane and tridecane (C11–13) or isohexadecane (IHD) led to wax crystal agglomeration and reduced stability. In contrast, longer chain oils like squalane (SQU) and white oil (WHO) showed lower polarity and better compatibility with BW, forming robust crystal networks and improving stability. Moreover, the heterogeneous structure enhanced stability. In the triglycerides caprylic/capric triglyceride (GTCC) system, the compatibility between the oil-phase ingredients reached a relatively balanced state, allowing BW crystals to adsorb at the oil–water interface, providing an additional mechanism to enhance emulsion stability.

Practical Applications: In cosmetic formulations, wax-based emulsions enhance moisturization while maintaining desirable sensory properties. However, the inherent crystallization behavior of wax components often compromises emulsion stability. This investigation systematically examines wax crystallization dynamics in cosmetic-grade W/O emulsions, establishing key structure–function relationships between crystal morphology and emulsion stability. The findings advance formulation optimization strategies for lip care and facial cream products, particularly in balancing wax content reduction with structural integrity preservation.

含蜡油包水(W/O)乳剂广泛应用于食品、制药和石油等行业。然而,蜡质材料对乳剂的稳定性提出了挑战。本研究考察了在五种不同的油体系(直链烷烃、酯类、支链烷烃和甘油三酯)中蜂蜡(BW)结晶行为与W/O乳液稳定性的关系。选择EM90作为乳化剂。结果表明,BW的结晶行为取决于其与乳化剂和油脂的相容性,直接影响乳液的稳定性。具体来说,在烷烃中,与十一烷、十三烷(C11-13)或异十六烷(IHD)的相容性较差,导致蜡晶体团聚,稳定性降低。相比之下,长链油如角鲨烷(SQU)和白油(WHO)的极性较低,与BW的相容性较好,形成了坚固的晶体网络,提高了稳定性。此外,非均相结构增强了稳定性。在甘油三酯-辛酸/甘油三酯(GTCC)体系中,油相成分之间的相容性达到了相对平衡的状态,使得BW晶体能够在油水界面吸附,为增强乳液稳定性提供了额外的机制。实际应用:在化妆品配方中,蜡基乳液增强保湿,同时保持理想的感官特性。然而,蜡组分固有的结晶行为往往会影响乳液的稳定性。本研究系统地研究了化妆品级W/O乳液中蜡的结晶动力学,建立了晶体形态与乳液稳定性之间的关键结构功能关系。研究结果推进了唇护理和面霜产品的配方优化策略,特别是在平衡蜡含量减少与结构完整性保存。
{"title":"Effect of Beeswax on the Stability of W/O Emulsion and Its Mechanism","authors":"Qianjie Zhang,&nbsp;HaoYue Ying,&nbsp;ZeDong Zheng,&nbsp;Liang Zhuang,&nbsp;Zijia Zhang,&nbsp;Wanping Zhang","doi":"10.1002/ejlt.70072","DOIUrl":"https://doi.org/10.1002/ejlt.70072","url":null,"abstract":"<div>\u0000 \u0000 <p>Wax-containing water-in-oil (W/O) emulsions are widely used in industries such as food, pharmaceuticals, and petroleum. However, waxy materials pose challenges to the stability of emulsions. This study investigated the relationship between beeswax (BW) crystallization behavior and W/O emulsion stability in five different oil systems: straight-chain alkanes, esters, branched-chain alkanes, and triglycerides. EM90 was chosen as an emulsifier. Results showed that BW crystallization behavior depended on its compatibility with emulsifiers and oils, directly impacting the stability of the emulsion. Specifically, in alkanes, poor compatibility with undecane and tridecane (C11–13) or isohexadecane (IHD) led to wax crystal agglomeration and reduced stability. In contrast, longer chain oils like squalane (SQU) and white oil (WHO) showed lower polarity and better compatibility with BW, forming robust crystal networks and improving stability. Moreover, the heterogeneous structure enhanced stability. In the triglycerides caprylic/capric triglyceride (GTCC) system, the compatibility between the oil-phase ingredients reached a relatively balanced state, allowing BW crystals to adsorb at the oil–water interface, providing an additional mechanism to enhance emulsion stability.</p>\u0000 <p><i>Practical Applications</i>: In cosmetic formulations, wax-based emulsions enhance moisturization while maintaining desirable sensory properties. However, the inherent crystallization behavior of wax components often compromises emulsion stability. This investigation systematically examines wax crystallization dynamics in cosmetic-grade W/O emulsions, establishing key structure–function relationships between crystal morphology and emulsion stability. The findings advance formulation optimization strategies for lip care and facial cream products, particularly in balancing wax content reduction with structural integrity preservation.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 11","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145522070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liver Tissue and Plasma Ceramide Variations in Metabolic Dysfunction-Associated Steatotic Liver Disease Based on the Number of Ceramide Carbon Atoms 基于神经酰胺碳原子数的代谢功能障碍相关脂肪变性肝病的肝组织和血浆神经酰胺变化
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-09-18 DOI: 10.1002/ejlt.70069
Achuthan Sourianarayanane, Christopher R. Brydges, Arthur J. McCullough

Ceramides play a complex role in metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH). Research shows that the plasma composition of ceramides differs among patients with MASLD and MASH, albeit with inconsistent results. In this study, an untargeted lipidomic analysis was performed on liver tissue and plasma simultaneously obtained from 72 participants at the time of histology. Ceramides were compared among patients with normal histology, MASLD without MASH, and MASH with and without advanced fibrosis in the liver tissue and plasma. Data analysis found a relative reduction in quantitation was observed for ceramides with 44–47 carbon atoms, whereas other ceramide species with ≤43 and ≥58 carbon atoms increased with progressive MASLD stages. Ceramides with ≥58 carbon atoms were significantly upregulated in patients with MASLD compared with controls and in patients with MASH compared with those without MASH. This was also correlated with the severity of steatosis and ballooning in liver histology. Specific ceramide species were also positively (e.g., ceramides 64:9;3O and 62:5;3O (r = 0.3–0.6)) or negatively (ceramide 46:5;3O (r = –0.5)) associated with the severity of histological features (p < 0.001). Plasma ceramide analysis showed similar trends but had no consistent pattern as observed in liver tissue. The findings suggest that the changes observed in liver tissue ceramide composition at different MASLD stages were not uniform. They differ based on the number of carbon atoms present, indicating the possibility that more than one metabolic pathway regulates ceramides in MASLD. Intervention to regulate specific ceramides can improve disease severity.

Practical Application: Ceramides are sphingolipids that play an important role in the pathophysiology of MASLD and its progression to MASH. A disparity between plasma and liver tissue ceramide levels at different stages of MASLD is seen. The effects of MASLD are not uniform for all species of ceramides. Compared with other ceramides, very long-chain ceramides show different patterns with MASLD progression. Intervention to modify specific ceramides (or groups) expression could benefit the management of MASLD and its progression.

神经酰胺在代谢功能障碍相关脂肪性肝病(MASLD)及其进行性形式代谢功能障碍相关脂肪性肝炎(MASH)中发挥着复杂的作用。研究表明,MASLD和MASH患者的血浆神经酰胺组成不同,尽管结果不一致。在本研究中,对72名参与者在组织学时同时获得的肝组织和血浆进行了非靶向脂质组学分析。将神经酰胺在组织学正常、无MASH的MASLD、伴有和不伴有肝组织和血浆晚期纤维化的MASH患者中进行比较。数据分析发现,含有44-47个碳原子的神经酰胺的定量相对减少,而含有≤43和≥58个碳原子的其他神经酰胺种类随着MASLD的进展而增加。与对照组相比,MASLD患者中碳原子≥58的神经酰胺显著上调,与没有MASH的患者相比,MASH患者中神经酰胺显著上调。这也与肝脏组织中脂肪变性和水肿的严重程度相关。特定神经酰胺种类也与组织学特征的严重程度呈正相关(例如,神经酰胺64:9;30和62:5;30 (r = 0.3-0.6))或负相关(神经酰胺46:5;30 (r = -0.5)) (p < 0.001)。血浆神经酰胺分析显示了类似的趋势,但在肝组织中没有观察到一致的模式。研究结果提示,在MASLD不同阶段肝组织神经酰胺组成的变化并不均匀。它们根据存在的碳原子数量而不同,这表明可能不止一种代谢途径调节MASLD中的神经酰胺。调节特定神经酰胺的干预可以改善疾病的严重程度。实际应用:神经酰胺是神经鞘脂类,在MASLD的病理生理和向MASH的发展中起重要作用。在MASLD的不同阶段,血浆和肝组织神经酰胺水平存在差异。MASLD对所有种类的神经酰胺的作用并不均匀。与其他神经酰胺相比,甚长链神经酰胺在MASLD进展过程中表现出不同的模式。干预修饰特定神经酰胺(或组)的表达有助于MASLD的管理及其进展。
{"title":"Liver Tissue and Plasma Ceramide Variations in Metabolic Dysfunction-Associated Steatotic Liver Disease Based on the Number of Ceramide Carbon Atoms","authors":"Achuthan Sourianarayanane,&nbsp;Christopher R. Brydges,&nbsp;Arthur J. McCullough","doi":"10.1002/ejlt.70069","DOIUrl":"https://doi.org/10.1002/ejlt.70069","url":null,"abstract":"<div>\u0000 \u0000 <p>Ceramides play a complex role in metabolic dysfunction-associated steatotic liver disease (MASLD) and its progressive form, metabolic dysfunction-associated steatohepatitis (MASH). Research shows that the plasma composition of ceramides differs among patients with MASLD and MASH, albeit with inconsistent results. In this study, an untargeted lipidomic analysis was performed on liver tissue and plasma simultaneously obtained from 72 participants at the time of histology. Ceramides were compared among patients with normal histology, MASLD without MASH, and MASH with and without advanced fibrosis in the liver tissue and plasma. Data analysis found a relative reduction in quantitation was observed for ceramides with 44–47 carbon atoms, whereas other ceramide species with ≤43 and ≥58 carbon atoms increased with progressive MASLD stages. Ceramides with ≥58 carbon atoms were significantly upregulated in patients with MASLD compared with controls and in patients with MASH compared with those without MASH. This was also correlated with the severity of steatosis and ballooning in liver histology. Specific ceramide species were also positively (e.g., ceramides 64:9;3O and 62:5;3O (<i>r</i> = 0.3–0.6)) or negatively (ceramide 46:5;3O (<i>r</i> = –0.5)) associated with the severity of histological features (<i>p</i> &lt; 0.001). Plasma ceramide analysis showed similar trends but had no consistent pattern as observed in liver tissue. The findings suggest that the changes observed in liver tissue ceramide composition at different MASLD stages were not uniform. They differ based on the number of carbon atoms present, indicating the possibility that more than one metabolic pathway regulates ceramides in MASLD. Intervention to regulate specific ceramides can improve disease severity.</p>\u0000 <p><b>Practical Application</b>: Ceramides are sphingolipids that play an important role in the pathophysiology of MASLD and its progression to MASH. A disparity between plasma and liver tissue ceramide levels at different stages of MASLD is seen. The effects of MASLD are not uniform for all species of ceramides. Compared with other ceramides, very long-chain ceramides show different patterns with MASLD progression. Intervention to modify specific ceramides (or groups) expression could benefit the management of MASLD and its progression.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 11","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145522164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Issue Information: Eur. J. Lipid Sci. Technol. 发行信息:欧元。J.油脂科学。抛光工艺。
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-09-11 DOI: 10.1002/ejlt.70067
{"title":"Issue Information: Eur. J. Lipid Sci. Technol.","authors":"","doi":"10.1002/ejlt.70067","DOIUrl":"https://doi.org/10.1002/ejlt.70067","url":null,"abstract":"","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 9","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ejlt.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145037905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fatty Acid Profile and Bioactive Properties of Oil From γ-Irradiated Peanut Seeds (Arachis hypogaea L.) γ辐照花生籽油脂肪酸谱及生物活性研究
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-09-04 DOI: 10.1002/ejlt.70068
Zeynep Alkın, Ümit Geçgel, Muhammed Talha Akbulut, Demet Apaydın

This study aimed to investigate the effect of ɣ-irradiation on the phytochemical properties and quality parameters of peanut oil, with a focus on identifying changes in key compounds such as fatty acids, phytosterols, tocopherols, and total phenolic content (TPC). In this research, peanuts harvested from Edirne/Meric region were exposed to Cobalt-60 gamma irradiation at different doses (1.5, 3.0, 4.0, and 5.0 kGy). The impacts of irradiation on some quality parameters, such as fatty acids, and the phytochemical properties, such as phytosterols, tocopherol, and TPC in the peanut oil, were determined. Gamma irradiation significantly altered oil quality parameters; for instance, tocopherol content decreased from 125.4 to 103.6 mg/kg and phenolic content declined from 8.98 to 0.63 mg GAE/kg at 5.0 kGy. Although TPC decreased proportionally with higher irradiation doses, palmitic acid (C16:0) and stearic acid (C18:0) increased significantly (p < 0.05). Likewise, gamma irradiation significantly affected the total sterol amount and other sterol contents detected, but it did not cause significant changes in the β-sitosterol content. Gamma ray irradiation caused a reduction in the oil content of peanuts. These findings provide insights into the potential applications and limitations of gamma irradiation in enhancing the quality and safety of peanut oil.

Practical Applications: Peanut is an important oilseed for human health due to the oil, protein, carbohydrates, and various vitamins/minerals it contains. On the other hand, peanuts are considered the riskiest food in terms of aflatoxin contamination, which causes serious health problems all over the world. In order to ensure food safety, it was aimed to irradiate peanut with gamma ray within the scope of prevention and control strategies of mycotoxigenic mold formation. This study investigated the effects of five different irradiation doses on phytochemical properties and some quality parameters in the peanut oil.

本研究旨在研究辐照对花生油植物化学性质和品质参数的影响,重点研究辐照后花生油中脂肪酸、植物甾醇、生育酚和总酚含量(TPC)等关键化合物的变化。在这项研究中,从Edirne/Meric地区收获的花生暴露在不同剂量(1.5、3.0、4.0和5.0 kGy)的钴-60 γ辐射下。研究了辐照对花生油中脂肪酸等品质参数和植物甾醇、生育酚、TPC等植物化学性质的影响。伽马辐照显著改变了油品质量参数;5.0 kGy时,生育酚含量从125.4 mg/kg下降到103.6 mg/kg,酚含量从8.98 mg/kg下降到0.63 mg/kg。随着辐照剂量的增加,TPC呈比例下降,但棕榈酸(C16:0)和硬脂酸(C18:0)显著升高(p < 0.05)。同样,伽马辐照对总甾醇量和其他检测到的甾醇含量有显著影响,但对β-谷甾醇含量没有显著影响。伽马射线照射导致花生含油量减少。这些发现为伽马辐照在提高花生油质量和安全性方面的潜在应用和局限性提供了见解。实际应用:花生富含油脂、蛋白质、碳水化合物和多种维生素/矿物质,是一种对人体健康至关重要的油籽。另一方面,就黄曲霉毒素污染而言,花生被认为是最危险的食物,黄曲霉毒素在全世界造成严重的健康问题。为了保证食品安全,在产霉菌霉菌形成的防治策略范围内对花生进行射线照射。研究了5种不同辐照剂量对花生油植物化学性质和部分品质参数的影响。
{"title":"Fatty Acid Profile and Bioactive Properties of Oil From γ-Irradiated Peanut Seeds (Arachis hypogaea L.)","authors":"Zeynep Alkın,&nbsp;Ümit Geçgel,&nbsp;Muhammed Talha Akbulut,&nbsp;Demet Apaydın","doi":"10.1002/ejlt.70068","DOIUrl":"https://doi.org/10.1002/ejlt.70068","url":null,"abstract":"<div>\u0000 \u0000 <p>This study aimed to investigate the effect of ɣ-irradiation on the phytochemical properties and quality parameters of peanut oil, with a focus on identifying changes in key compounds such as fatty acids, phytosterols, tocopherols, and total phenolic content (TPC). In this research, peanuts harvested from Edirne/Meric region were exposed to Cobalt-60 gamma irradiation at different doses (1.5, 3.0, 4.0, and 5.0 kGy). The impacts of irradiation on some quality parameters, such as fatty acids, and the phytochemical properties, such as phytosterols, tocopherol, and TPC in the peanut oil, were determined. Gamma irradiation significantly altered oil quality parameters; for instance, tocopherol content decreased from 125.4 to 103.6 mg/kg and phenolic content declined from 8.98 to 0.63 mg GAE/kg at 5.0 kGy. Although TPC decreased proportionally with higher irradiation doses, palmitic acid (C16:0) and stearic acid (C18:0) increased significantly (<i>p </i>&lt; 0.05). Likewise, gamma irradiation significantly affected the total sterol amount and other sterol contents detected, but it did not cause significant changes in the β-sitosterol content. Gamma ray irradiation caused a reduction in the oil content of peanuts. These findings provide insights into the potential applications and limitations of gamma irradiation in enhancing the quality and safety of peanut oil.</p>\u0000 <p><i>Practical Applications</i>: Peanut is an important oilseed for human health due to the oil, protein, carbohydrates, and various vitamins/minerals it contains. On the other hand, peanuts are considered the riskiest food in terms of aflatoxin contamination, which causes serious health problems all over the world. In order to ensure food safety, it was aimed to irradiate peanut with gamma ray within the scope of prevention and control strategies of mycotoxigenic mold formation. This study investigated the effects of five different irradiation doses on phytochemical properties and some quality parameters in the peanut oil.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 11","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145521370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genotype-Dependent Variation in Fatty Acids and Lipophilic Bioactive Compounds in Quinoa (Chenopodium quinoa Willd.) Seeds: Insights Into Adaptive Potential Under Central European Conditions 藜麦(Chenopodium Quinoa Willd.)脂肪酸和亲脂性生物活性化合物的基因型依赖性变异种子:中欧条件下的适应潜力
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-09-01 DOI: 10.1002/ejlt.70064
Małgorzata Tańska, Krzysztof Gęsiński, Dorota Ogrodowska, Radomir Graczyk

This study aimed to comprehensively characterize the lipophilic compounds—including fatty acids (FAs), phytosterols (PSs), tocols (TCs), carotenoids (CAs), and squalene (SQ)—in quinoa seeds from 25 genotypes originating from South America, North America, and Europe, acclimatized to Polish growing conditions. Additionally, the contents of these compounds were correlated with seed physical properties and the antioxidant capacity (AC) of the lipophilic fraction. Total lipid content ranged from 5.24% to 7.11%, with polyunsaturated fatty acids (PUFAs) accounting for 48.41%–51.76% of total FAs. Furthermore, quinoa seeds contained 66.44–117.45 mg SQ, 55.77–88.54 mg PSs, 9.68–13.65 mg TCs, and up to 1.14 mg CAs per 100 g of seed dry matter (d.m.). AC ranged from 25.13 to 42.57 m trolox equivalents (TEs)/100 g seed d.m. European genotypes exhibited smaller seeds with lower lipid content, yet had higher levels of PUFAs, SQ, and TCs. In contrast, North American genotypes showed the greatest variability in lipophilic compound composition.

Practical applications: Detailed profiling of lipophilic compounds in quinoa seeds provides valuable insights for both the food and health industries. The high levels of polyunsaturated fatty acids, phytosterols, tocols, carotenoids, and squalene reinforce quinoa's potential as a functional food ingredient with substantial health benefits, including cardiovascular protection and antioxidant activity. The results can support the selection of genotypes in breeding programs aimed at improving lipid profiles and guide food manufacturers in identifying optimal sources for oil extraction and product enrichment. The observed variation in lipid composition across quinoa genotypes enables targeted use in health-oriented products such as nutraceuticals, dietary supplements, and functional foods. Moreover, regional differences in lipophilic compound profiles allow for the strategic adaptation of quinoa varieties to specific dietary and industrial applications, facilitating tailored nutrition for diverse consumer groups.

本研究旨在全面表征来自南美、北美和欧洲的25种基因型藜麦种子中的亲脂化合物,包括脂肪酸(FAs)、植物甾醇(ps)、工具(tc)、类胡萝卜素(CAs)和角鲨烯(SQ),并适应波兰的生长条件。此外,这些化合物的含量与种子的物理性质和亲脂部分的抗氧化能力(AC)有关。总脂肪含量为5.24% ~ 7.11%,其中多不饱和脂肪酸(PUFAs)占总脂肪酸的48.41% ~ 51.76%。此外,藜麦种子每100 g种子干物质(d.m)含有66.44 ~ 117.45 mg SQ, 55.77 ~ 88.54 mg ps, 9.68 ~ 13.65 mg TCs和高达1.14 mg CAs。AC范围为25.13 ~ 42.57 m trolox当量(TEs)/100 g种子d.m。欧洲基因型的种子较小,脂质含量较低,但PUFAs、SQ和TCs水平较高。相比之下,北美基因型在亲脂化合物组成上表现出最大的变异性。实际应用:藜麦种子中亲脂化合物的详细分析为食品和健康行业提供了有价值的见解。高含量的多不饱和脂肪酸、植物甾醇、工具、类胡萝卜素和角鲨烯增强了藜麦作为一种功能性食品成分的潜力,对健康有很大的好处,包括心血管保护和抗氧化活性。该结果可为改善油脂谱的育种计划中基因型的选择提供支持,并指导食品制造商确定最佳的油脂提取和产品富集来源。观察到的藜麦基因型中脂质组成的差异使其能够有针对性地用于保健产品,如营养保健品、膳食补充剂和功能食品。此外,亲脂化合物的区域差异使得藜麦品种能够根据特定的饮食和工业应用进行战略性调整,从而为不同的消费者群体提供量身定制的营养。
{"title":"Genotype-Dependent Variation in Fatty Acids and Lipophilic Bioactive Compounds in Quinoa (Chenopodium quinoa Willd.) Seeds: Insights Into Adaptive Potential Under Central European Conditions","authors":"Małgorzata Tańska,&nbsp;Krzysztof Gęsiński,&nbsp;Dorota Ogrodowska,&nbsp;Radomir Graczyk","doi":"10.1002/ejlt.70064","DOIUrl":"https://doi.org/10.1002/ejlt.70064","url":null,"abstract":"<div>\u0000 \u0000 <p>This study aimed to comprehensively characterize the lipophilic compounds—including fatty acids (FAs), phytosterols (PSs), tocols (TCs), carotenoids (CAs), and squalene (SQ)—in quinoa seeds from 25 genotypes originating from South America, North America, and Europe, acclimatized to Polish growing conditions. Additionally, the contents of these compounds were correlated with seed physical properties and the antioxidant capacity (AC) of the lipophilic fraction. Total lipid content ranged from 5.24% to 7.11%, with polyunsaturated fatty acids (PUFAs) accounting for 48.41%–51.76% of total FAs. Furthermore, quinoa seeds contained 66.44–117.45 mg SQ, 55.77–88.54 mg PSs, 9.68–13.65 mg TCs, and up to 1.14 mg CAs per 100 g of seed dry matter (d.m.). AC ranged from 25.13 to 42.57 m trolox equivalents (TEs)/100 g seed d.m. European genotypes exhibited smaller seeds with lower lipid content, yet had higher levels of PUFAs, SQ, and TCs. In contrast, North American genotypes showed the greatest variability in lipophilic compound composition.</p>\u0000 <p><i>Practical applications</i>: Detailed profiling of lipophilic compounds in quinoa seeds provides valuable insights for both the food and health industries. The high levels of polyunsaturated fatty acids, phytosterols, tocols, carotenoids, and squalene reinforce quinoa's potential as a functional food ingredient with substantial health benefits, including cardiovascular protection and antioxidant activity. The results can support the selection of genotypes in breeding programs aimed at improving lipid profiles and guide food manufacturers in identifying optimal sources for oil extraction and product enrichment. The observed variation in lipid composition across quinoa genotypes enables targeted use in health-oriented products such as nutraceuticals, dietary supplements, and functional foods. Moreover, regional differences in lipophilic compound profiles allow for the strategic adaptation of quinoa varieties to specific dietary and industrial applications, facilitating tailored nutrition for diverse consumer groups.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Ethanolamine Glycerophospholipids Alleviate Acute Hepatic Injury in Mice: A Comparison of Two Subclasses 膳食乙醇胺甘油磷脂减轻小鼠急性肝损伤:两个亚类的比较
IF 1.8 3区 农林科学 Q3 FOOD SCIENCE & TECHNOLOGY Pub Date : 2025-09-01 DOI: 10.1002/ejlt.70063
Shinji Yamashita, Yuki Tominaga, Kohei Kanno, Ryosuke Sogame, Kenichiro Shimada, Teruo Miyazawa, Mikio Kinoshita

Ethanolamine plasmalogen (PlsEtn) is a subclass of ethanolamine glycerophospholipids (EtnGpls) that has been reported to exhibit physiological and nutritional hepatic functions. However, the effects of dietary PlsEtn on acute liver injury remain unclear. In the present study, we investigated the dietary effects of PlsEtn on acute hepatic injury in mice treated with an intraperitoneal injection of lipopolysaccharide and d-galactosamine (LG). The results obtained after administering the PlsEtn-rich diet were compared with those obtained after administration of a phosphatidylethanolamine (PtdEtn)-rich diet, a major subclass of hepatic EtnGpls. Dietary EtnGpl rich in PlsEtn or PtdEtn suppressed the LG-induced increase in plasma aspartate aminotransferase activity, which is a marker of liver cell injury. In the livers of LG-treated mice, the PlsEtn-rich diet suppressed the expression of cleaved caspase-3, an effector caspase for apoptosis, whereas the PtdEtn-rich diet suppressed p53 expression and maintained B-cell lymphoma 2 expression. Additionally, the PlsEtn-rich diet increased the ratio of docosahexaenoic acid, an anti-inflammatory factor, to total fatty acids in the livers of LG-treated mice, whereas this effect was not observed in mice fed the PtdEtn-rich diet. These results suggest that dietary EtnGpls alleviate acute hepatic injury; however, the mechanism of suppression may differ depending on its subclass.

Practical applications: Analyzing the beneficial effects of PlsEtn and PtdEtn, both subclasses of EtnGpl, contributes to understanding the protective mechanisms of glycerophospholipids against hepatic injuries. Although the concentration of PlsEtn in the liver is less than one-tenth that of PtdEtn, endogenous PlsEtn has been reported to exhibit anti-inflammatory effects and improve lipid metabolism in the liver. Consequently, both dietary PlsEtn and PtdEtn demonstrate significant hepatic protection; however, their mechanisms of suppression differ. These findings suggest that the structural characteristics of PlsEtn and PtdEtn, which are responsible for hepatic protection, vary.

乙醇胺plasmalogen (PlsEtn)是乙醇胺甘油磷脂(EtnGpls)的一个亚类,已被报道具有生理和营养肝脏功能。然而,膳食PlsEtn对急性肝损伤的影响尚不清楚。在本研究中,我们研究了PlsEtn对腹腔注射脂多糖和d-半乳糖胺(LG)治疗小鼠急性肝损伤的饮食影响。给予富plsetn饮食后获得的结果与给予富磷脂酰乙醇胺(PtdEtn)饮食后获得的结果进行了比较,PtdEtn是肝脏EtnGpls的一个主要亚类。饮食中富含PlsEtn或PtdEtn的EtnGpl抑制了lg诱导的血浆天冬氨酸转氨酶活性的升高,而天冬氨酸转氨酶是肝细胞损伤的标志。在lg处理的小鼠肝脏中,富含plsetn的饮食抑制了cleaved caspase-3(一种凋亡效应caspase)的表达,而富含ptdetn的饮食抑制了p53的表达并维持了b细胞淋巴瘤2的表达。此外,富含plsetn的饮食增加了lg处理小鼠肝脏中二十二碳六烯酸(一种抗炎因子)与总脂肪酸的比例,而在喂食富含ptdetn的饮食的小鼠中没有观察到这种效果。提示饲粮中添加EtnGpls可减轻急性肝损伤;然而,抑制机制可能因其亚型而异。实际应用:分析EtnGpl的两个亚类PlsEtn和PtdEtn的有益作用,有助于理解甘油磷脂对肝损伤的保护机制。虽然PlsEtn在肝脏中的浓度不到PtdEtn的十分之一,但据报道内源性PlsEtn具有抗炎作用,并能改善肝脏的脂质代谢。因此,膳食中的PlsEtn和PtdEtn均显示出显著的肝脏保护作用;然而,它们的抑制机制不同。这些发现表明,负责肝脏保护的PlsEtn和PtdEtn的结构特征各不相同。
{"title":"Dietary Ethanolamine Glycerophospholipids Alleviate Acute Hepatic Injury in Mice: A Comparison of Two Subclasses","authors":"Shinji Yamashita,&nbsp;Yuki Tominaga,&nbsp;Kohei Kanno,&nbsp;Ryosuke Sogame,&nbsp;Kenichiro Shimada,&nbsp;Teruo Miyazawa,&nbsp;Mikio Kinoshita","doi":"10.1002/ejlt.70063","DOIUrl":"https://doi.org/10.1002/ejlt.70063","url":null,"abstract":"<div>\u0000 \u0000 <p>Ethanolamine plasmalogen (PlsEtn) is a subclass of ethanolamine glycerophospholipids (EtnGpls) that has been reported to exhibit physiological and nutritional hepatic functions. However, the effects of dietary PlsEtn on acute liver injury remain unclear. In the present study, we investigated the dietary effects of PlsEtn on acute hepatic injury in mice treated with an intraperitoneal injection of lipopolysaccharide and <span>d</span>-galactosamine (LG). The results obtained after administering the PlsEtn-rich diet were compared with those obtained after administration of a phosphatidylethanolamine (PtdEtn)-rich diet, a major subclass of hepatic EtnGpls. Dietary EtnGpl rich in PlsEtn or PtdEtn suppressed the LG-induced increase in plasma aspartate aminotransferase activity, which is a marker of liver cell injury. In the livers of LG-treated mice, the PlsEtn-rich diet suppressed the expression of cleaved caspase-3, an effector caspase for apoptosis, whereas the PtdEtn-rich diet suppressed p53 expression and maintained B-cell lymphoma 2 expression. Additionally, the PlsEtn-rich diet increased the ratio of docosahexaenoic acid, an anti-inflammatory factor, to total fatty acids in the livers of LG-treated mice, whereas this effect was not observed in mice fed the PtdEtn-rich diet. These results suggest that dietary EtnGpls alleviate acute hepatic injury; however, the mechanism of suppression may differ depending on its subclass.</p>\u0000 <p><i>Practical applications</i>: Analyzing the beneficial effects of PlsEtn and PtdEtn, both subclasses of EtnGpl, contributes to understanding the protective mechanisms of glycerophospholipids against hepatic injuries. Although the concentration of PlsEtn in the liver is less than one-tenth that of PtdEtn, endogenous PlsEtn has been reported to exhibit anti-inflammatory effects and improve lipid metabolism in the liver. Consequently, both dietary PlsEtn and PtdEtn demonstrate significant hepatic protection; however, their mechanisms of suppression differ. These findings suggest that the structural characteristics of PlsEtn and PtdEtn, which are responsible for hepatic protection, vary.</p>\u0000 </div>","PeriodicalId":11988,"journal":{"name":"European Journal of Lipid Science and Technology","volume":"127 10","pages":""},"PeriodicalIF":1.8,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145297149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
European Journal of Lipid Science and Technology
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1