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Viridans Group Streptococci and the Oral Ecosystem 翠绿菌群链球菌与口腔生态系统
Pub Date : 2016-04-06 DOI: 10.15197/EJGM.1440
S. Dhotre, Namdev M. Suryawanshi, S. Selkar, B. Nagoba
The human oral cavity is the highly selective environment, which can be colonized by certain microbes. Viridans group streptococci are the most common bacterial isolates along with many other aerobic and anaerobic bacteria. S. salivarius is the most common viridians group streptococcus followed by S. mitis, S. sanguis, S. milleri, S. gordonii and S. mutans. The diverse habitat unique to the oral cavity together with a variety of nutrients is supportive to mixed population. These members of the resident oral flora, including viridians group streptococci, are responsible for colonization resistance, i.e., they prevent colonization / invasion by more pathogenic exogenous bacterial pathogens. Disruption of the oral ecosystem may lead to impairment of colonization resistance leading to higher rates of colonization by more pathogenic exogenous bacterial pathogens. Thus, viridians group streptococci normally present in the oral cavity play a significant role in oral health.
人类口腔是一个高度选择性的环境,某些微生物可以在其中定植。翠绿菌群链球菌是最常见的细菌分离物,还有许多其他的好氧和厌氧细菌。唾液链球菌是最常见的葡萄球菌,其次是米氏链球菌、血状链球菌、米勒氏链球菌、戈多氏链球菌和变形链球菌。口腔所特有的多样化栖息地以及各种营养物质为混合人口提供了支持。这些常驻口腔菌群的成员,包括绿脉菌群链球菌,负责定植抗性,即它们阻止更多致病性外源细菌病原体的定植/入侵。口腔生态系统的破坏可能导致定植抗性的损害,导致更多致病性外源细菌病原体的定植率更高。因此,通常存在于口腔中的翠绿菌群链球菌在口腔健康中起着重要作用。
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引用次数: 2
Urinary System Infection Caused by Paecilomyces Variotti 变异拟青霉引起的泌尿系统感染
Pub Date : 2016-04-06 DOI: 10.15197/EJGM.1472
S. Çolakoglu, S. Durmaz, H. Poyrazoğlu, F. F. Tekinsen, M. Atalay, A. Koç
Fungal organisms are one of the important factor in nosocomial urinary tract infections caused by endo-urological procedures. Herein we report a case of pyelonephritis caused by Paecilomyces variotti in a 14-month-old child following an uriner tract operation. He had operation in 3.5-month-old for reason of ureteropelvic junction obstruction. Approximately two months after the operation a tissue fragments ejected from urinary tract. The patient admitted to our hospital because of bimonthly recurrence was occured. This tissue fragment was sent for fungal studies to our department. Direct microscopy revealed hyphae. P. variotii was isolated from discarded tissue fragments. Cure was achieved by 2 mg / kg / day for 15 days treatment with amphotericin B.
真菌是泌尿外科手术引起院内尿路感染的重要因素之一。我们在此报告一例由异芽拟青霉引起的肾盂肾炎在一个14个月大的孩子后尿路手术。因肾盂输尿管连接处梗阻,于3.5月龄行手术。手术后大约两个月有组织碎片从泌尿道排出。该患者因每两个月复发而入院。这个组织碎片被送到我们系做真菌研究。直接显微镜下可见菌丝。从丢弃的组织碎片中分离到异芽孢杆菌。两性霉素B以2 mg / kg /天治疗15天,达到治愈。
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引用次数: 2
The Predictive Role of Neutrophil to Lymphocyte ratio in Chronic Obstructive Pulmonary Disease 中性粒细胞与淋巴细胞比值在慢性阻塞性肺疾病中的预测作用
Pub Date : 2016-04-06 DOI: 10.15197/EJGM.1554
B. Bilir, N. Altintas, M. Aydın, M. Oran, S. Ozsu, Umit Tutar
Objective:Recently neutrophil-to-lymphocyte ratio (NLR) -the level of neutrophil reflecting the severity of inflammation and lymphocyte occurring after physiological stress has been gaining popularity, which was, along with other inflammatory markers, commonly accepted as an accurate marker of the inflammatory status.In this multi-centered study, an early, rapid, and low-cost diagnosis method was investigated. To this end, the correlation between chronic obstructive pulmonary disease and inflammation was planned to be utilized and whether neutrophil-to-lymphocyte ratio can be used as a valid tool in the diagnosis of acute exacerbations of chronic obstructive pulmonary disease was investigated.Method:We retrospectively enrolled the 467 patients. Control group included sex and age-matched healthy people.C-Reactive protein, forced expiratory volume-1, forced vital capacity, complete blood count and clinical data A receiver-operating characteristic curve analysis was performed to determine the best cut-off value of N/L ratio and C-Reaktif protein to predict the exacerbation. Two-sided p values <0.05 were considered statistically significant.Results:By spearmananalysis, there was a strong correlation between.C-Reactive proteinand N/L ratio in both stable group (r=0.436, p<0.001) and exacerbationgroup (r=0.534, p=0.001).Conclusion:Neutrophil/lymphocyte ratio may bea useful predictor of inflammation in chronic obstructive pulmonary disease and acute exacarbation of chronic obstructive pulmonary disease patients.
目的:近年来,中性粒细胞与淋巴细胞比值(NLR)——反映生理应激后炎症和淋巴细胞发生的严重程度的中性粒细胞水平越来越受欢迎,它与其他炎症标志物一起被普遍认为是炎症状态的准确标志。本研究旨在探讨一种早期、快速、低成本的诊断方法。为此,拟利用慢性阻塞性肺疾病与炎症的相关性,探讨中性粒细胞与淋巴细胞比值能否作为诊断慢性阻塞性肺疾病急性加重期的有效工具。方法:对467例患者进行回顾性研究。对照组为性别、年龄相匹配的健康人,采用c反应蛋白、用力呼气量-1、用力肺活量、全血细胞计数及临床资料进行受体-工作特征曲线分析,确定N/L比和C-Reaktif蛋白预测病情恶化的最佳截断值。双侧p值<0.05认为有统计学意义。结果:经spearman分析,稳定组(r=0.436, p<0.001)和加重组(r=0.534, p=0.001) c -反应蛋白与N/L比值有较强的相关性。结论:中性粒细胞/淋巴细胞比值可能是慢性阻塞性肺疾病患者炎症和慢性阻塞性肺疾病急性加重的有效预测因子。
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引用次数: 14
Activity-Based Costing Management and Hospital Cost in Patients with Chronic Obstructive Pulmonary Disease 慢性阻塞性肺疾病患者作业成本管理与住院成本
Pub Date : 2016-04-06 DOI: 10.15197/EJGM.1537
M. Ortakoylu, S. Altın, A. Bahadır, H. Urer, A. Kosar, Ali Coskun
Objective:Chronic obstructive pulmonary disease (COPD), one of the most important causes of morbidity and mortality worldwide, is an important economic burden due to hospitalizations, incapacity to work, and disability. The present study aimed to demonstrate one-year activity-based costing of services provided by service-providing centers of Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, which provides services for a wide region, and to present the share of COPD in this cost.Method:Income and expense cost sheets of the year 2011 of the hospital was reviewed. The activity-based costing system was used for calculations. After the identification of the main service centers's expenses of the hospital,the annual expenditure of each unit was calculated. The cost of COPD patients was calculated based on the expenditures of the units caring for COPD patients. The cost per unit of services like radiography, laboratory and pulmonary function tests was calculated and added to the cost of COPD patients.Results:Annual cost according to the activity-based costing system wasfound to be 3,839,788.32 US Dollars ($) for COPD patients examined andtreated as inpatient (2,531,290.9 $ ) , or at emergency room (586,170.7$) , or at respiratory intensive care unit (419,282.11$) , or at polyclinics(303,044.5 . It accounted for 19.5% of one-year hospital cost (totalannual hospital cost was 20,055,400.8 US Dollars).Conclusion:The rising economic burden of COPD corralates with acute exacerbations. As COPD is a high-cost disease, measures should be of priority to reduce economic burden of the disease.
目的:慢性阻塞性肺疾病(COPD)是世界范围内最重要的发病和死亡原因之一,因住院、丧失工作能力和残疾而成为重要的经济负担。本研究旨在证明Yedikule胸部疾病和胸外科培训与研究医院的服务提供中心提供的服务的一年基于活动的成本计算,该中心为广泛的地区提供服务,并展示COPD在该成本中的份额。方法:对该院2011年度收入费用成本表进行回顾。采用作业成本法进行计算。在确定医院主要服务中心的费用后,计算各单位的年度费用。COPD患者的成本是根据照顾COPD患者的单位的支出来计算的。计算了放射照相、实验室和肺功能检查等服务的单位成本,并将其添加到慢性阻塞性肺病患者的成本中。结果:根据以活动为基础的成本核算系统,COPD患者作为住院检查和治疗的年成本为3,839,788.32美元(2,531,290.9美元),或在急诊室(586,170.7美元),或在呼吸重症监护病房(419,282.11美元),或在综合诊所(303,044.5美元)。占一年住院费用的19.5%(全年住院总费用为20,055,400.8美元)。结论:慢性阻塞性肺病经济负担的增加与急性加重有关。由于慢性阻塞性肺病是一种高成本疾病,应优先采取措施减轻该病的经济负担。
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引用次数: 4
Miscible Two Diseases in Old Age: Hypopituitarism and Pseudogout 老年可混种的两种疾病:垂体功能减退症和假性症
Pub Date : 2016-01-24 DOI: 10.15197/ejgm.01368
Huseyin Gulyer, Bülent Savut, M. Şahin, T. Gungor, A. Kucuk, M. Kulaksızoğlu, A. Kaya
Calcium pyrophosphate dihydrate deposition disease is a dis- ease characterized by collecting of crystals in hyaline carti- lage, fibrocartilage and soft tissues, related to many endo - crine and metabolic conditions, and seen more commonly in old age. Hypopituitarism may occur in old age with fatigue, decrease in libido, weight loss and musculoskeletal symptoms as a major cause of the overall condition impairment. As one gets older, the signs of these two diseases may progress even without any significant disease. The natural process which comes with old age, and pseudogout and hypopituitarism can mask one to another clinically and the symptoms of three situ- ation may be overlapping. This can lead to difficulty and delay in diagnosis. Our case was an elderly female patient diagnosed with hypopituitarism and pseudogout.
二水合焦磷酸钙沉积病是一种以透明软骨、纤维软骨和软组织中晶体聚集为特征的疾病,与许多内分泌和代谢疾病有关,常见于老年。垂体功能减退可发生在老年疲劳,性欲下降,体重减轻和肌肉骨骼症状,作为整体状况损害的主要原因。随着年龄的增长,这两种疾病的症状可能会在没有任何重大疾病的情况下发展。随着老年的自然过程,假性失明和垂体功能减退在临床上可以相互掩盖,三位症状可能重叠。这可能导致诊断困难和延误。我们的病例是一位老年女性患者,诊断为垂体功能减退和假性外翻。
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引用次数: 0
Epithelial-Myoepithelial Carcinoma with High Grade Transformation of Nasal Cavity 鼻腔上皮-肌上皮癌伴高级别转化
Pub Date : 2016-01-16 DOI: 10.15197/EJGM.01447
F. Kılınç, Munire Çağın, Erkun Tuncer, D. Efe, S. Özen
High grade transformation in epithelial-myoepithelial carcino¬ma is a recently defined entity with only a few cases reported in the literature. We present a 59 years old female patient with a polypoid lesion in nasal cavity, together with clinical com¬plaints as recurrent epistaxis and stuffiness. Histological and immunohistochemical examination of the surgically excised le¬sion revealed a diagnosis of epithelialmyoepithelial carcino¬ma with high grade transformation. Epithelial-myoepithelial carcinoma originates from salivary glands, mainly parotid gland. Other affected sites are submandibular gland and minor sali¬vary glands. Epithelialmyoepithelial carcinoma is characterized by double layered duct-like structures. Greater cytologi¬cal atypia, higher mitotic rate, presence of necrosis and loss of the biphasic ductlike structures are features of high grade transformation. Local recurrence and cervical lymph node me¬tastases are seen with low incidence in classical epithelial-myoepithelial carcinoma, whereas epithelial-myoepithelial carcinoma with high grade transformation has high tendency for lymph node and distant metastases.
上皮-肌上皮癌的高级别转化是一个最近才被定义的实体,只有少数病例在文献中报道。我们报告一位59岁的女性患者,鼻腔息肉样病变,临床主诉为复发性鼻出血和鼻塞。手术切除病灶的组织学和免疫组织化学检查显示诊断为上皮肌上皮癌伴高级别转化。上皮-肌上皮癌起源于唾液腺,主要是腮腺。其他受累部位为下颌骨腺和小唾液腺。上皮肌上皮癌以双层管状结构为特征。更高的细胞学非典型性,更高的有丝分裂率,坏死的存在和双相导管样结构的丧失是高级别转化的特征。典型上皮-肌上皮癌的局部复发和颈部淋巴结转移发生率较低,而高度转化的上皮-肌上皮癌有淋巴结和远处转移的高倾向。
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引用次数: 0
Asymptomatic Mediastinal Hematoma as a Complication of Ultrasound-Guided Internal Jugular Vein Catheterization 无症状纵隔血肿作为超声引导颈内静脉置管的并发症
Pub Date : 2016-01-16 DOI: 10.15197/EJGM.01452
F. Yıldırım, I. Kara, Büsra Yürümez, G. Aygencel, M. Turkoglu
Central venous catheterization is a frequently performed procedure in the intensive care units (ICU) for various treatments such as iv therapy, parenteral nutrition and hemodialysis but occasionally encountered complications can be fatal. Therefore, safe insertion with confirmation of correct positioning of the catheter is vital. Ultrasound (US)-guided insertion of catheters has been used widely, and its safety and efficacy have been demonstrated in several studies. However, this technique is not free from complications, such as carotid artery puncture, hemothorax, pneumothorax and infection. In this case, anterior mediastinal hematoma proceeded after US-guided internal jugular vein (IJV) catheterization.
中心静脉置管是重症监护病房(ICU)中常用的一种治疗方法,用于静脉治疗、肠外营养和血液透析,但偶尔遇到的并发症可能是致命的。因此,安全插入并确认导管的正确位置至关重要。超声引导下的置管已被广泛应用,其安全性和有效性已在多项研究中得到证实。然而,该技术并非没有并发症,如颈动脉穿刺、血胸、气胸和感染。在这个病例中,前纵隔血肿在us引导下颈内静脉(IJV)置管后发生。
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引用次数: 2
Severe Hyoglycemic Attacks and Remission of Type 2 Diabetes and Psoriasis Due to Acitretin 阿维素对2型糖尿病和牛皮癣的严重低血糖发作和缓解
Pub Date : 2016-01-16 DOI: 10.15197/ejgm.01446
S. Shukurov, R. Erkoç, M. Ilhan, M. Ozdemir, M. Alay, E. Tasan
An 59 year old women with type two diabetes and psoriasis admitted with severe hypoglycemic attacks. Acitretin use was identified as the cause of this attacks. Two years after cessation of acitretin, she is still in remission of diabetes and psoriasis. This condition was attributed to extraordinary prolonged use of acitretin.
一位59岁的女性,患有2型糖尿病和牛皮癣,因严重的低血糖发作而入院。阿曲维素的使用被认为是导致这种发作的原因。停用阿维甲素两年后,糖尿病和牛皮癣仍处于缓解期。这种情况归因于超长时间使用阿维素。
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引用次数: 1
The Role of Ultrasonography for Differentiating and Management of Malignant Cervical Lymph Nodes 超声检查在颈部恶性淋巴结鉴别和治疗中的作用
Pub Date : 2016-01-16 DOI: 10.15197/EJGM.01416
S. Doğan, Afra Yıldırım, Refika Erbakirci, A. Okur, S. Çağlı, E. Mavili, İ. Yüce, E. Güney, M. Öztürk
Objective:To investigate the value of grey scale and Doppler ultrasonography in the assessment of metastatic and lymphomatous cervical lymph nodes.Methods:One hundred and nineteen malignant cervical lymph nodes in 119 patients diagnosed as malignant according to grey scale, color Doppler and spectral Doppler ultrasonography features were included in this study. The sizes, shape, echo pattern, echogenic hilus, nodal border, cystic necrosis and coagulation necrosis, vascular distribution pattern, resistivity and pulsatility index values of lymph nodes were noted. All patients had histopathological diagnosis.Results:The final diagnosis of the 42 lymph nodes was lymphoma, and of the 77 lymph nodes was carcinoma metastasis (33 thyroid carcinoma metastasis and 44 squamous cell carcinoma metastasis). While a hyperechoic pattern and calcification were detected in the lymph nodes originating from thyroid carcinoma as 39% and 33%, respectively, a reticular pattern (26%) and low resistive and pulsatility indices were detected in lymph nodes originating from lymphoma. These criteria were statistically significant for the differential diagnosis (p<0.05). Size, shape, hypoechoic echo pattern, absence of echogenic hilus, nodal border, cystic necrosis, coagulation necrosis and vascular distribution pattern were not found to be significant for the detection of a primary tumour.Conclusion:Hyperechoic echo pattern, reticular pattern, calcification, low resistivity and pulsatility indices are useful parameters for the differential diagnosis of malignant cervical lymph nodes. These ultrasonography critaria can be used for assesment and management of unknown primary malign neck nodes.
目的:探讨灰阶及多普勒超声在颈淋巴结转移及淋巴瘤诊断中的价值。方法:对119例经灰阶、彩色多普勒及频谱多普勒超声诊断为恶性的患者的191例颈部恶性淋巴结进行分析。观察淋巴结的大小、形态、回声形态、回声门、淋巴结边界、囊性坏死、凝血坏死、血管分布、电阻率、搏动指数等。所有患者均经组织病理学诊断。结果:42例淋巴结最终诊断为淋巴瘤,77例淋巴结最终诊断为癌转移(甲状腺癌转移33例,鳞状细胞癌转移44例)。甲状腺癌淋巴结表现为高回声型和钙化型,分别占39%和33%,淋巴瘤淋巴结表现为网状型(26%),低阻性和搏动性指数。这些指标对鉴别诊断有统计学意义(p<0.05)。大小、形状、低回声模式、无回声门、结节边界、囊性坏死、凝血坏死和血管分布模式对原发性肿瘤的检测没有显著意义。结论:高回声型、网状型、钙化、低电阻率及脉搏性指标是鉴别颈部恶性淋巴结的有用指标。这些超声检查标准可用于评估和治疗未知的原发性恶性颈部淋巴结。
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引用次数: 4
Rhinolith Associated with Pseudomonas Aeruginosa in a Diabetic Patient 糖尿病患者与铜绿假单胞菌相关的鼻石
Pub Date : 2016-01-16 DOI: 10.15197/EJGM.01461
M. Şentürk, Gültekin Övet, N. Alatas, Isa Azgin, O. Erdur
Rhinolithiasis is a rare condition in routine otolaryngologic practice and may cause chronic sinusitis. Pseudomonas aeruginosa is frequently found microorganism in chronic sinusitis. Although pseudomonas infections are not uncommon in chronic sinusitis, no report of co-existance of the trinity of rhinolithiasis, nasal pseudomonas infection and diabetes mellitus was found in the literature. This paper discusses the clinical features of rhinolithiasis in a 45-year-old diabetic female who presented with rhinolithiasis and nasal pseudomonas infection.
鼻石症在常规耳鼻喉科是一种罕见的情况,并可能引起慢性鼻窦炎。铜绿假单胞菌是慢性鼻窦炎中常见的微生物。虽然假单胞菌感染在慢性鼻窦炎中并不少见,但文献中尚未发现鼻结石、鼻假单胞菌感染与糖尿病三位一体共存的报道。本文讨论了一位45岁糖尿病女性鼻结石的临床特征,她表现为鼻结石和鼻假单胞菌感染。
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引用次数: 1
期刊
European journal of general medicine
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