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Ultrasound prediction of spontaneous abortions in live embryos in the first trimester 妊娠早期活胚胎自然流产的超声预测
Pub Date : 2016-12-03 DOI: 10.29333/EJGM/81756
H. Alptekin, T. Acar, H. Işık, T. Cengiz
Introduction:To generate a prediction model for miscarriage in women with a viable single pregnancy from first-trimester ultrasound findings and maternal characteristics.Material and Methods:A prospective, cross-sectional study of 415 singleton pregnancies was performed. The initial ultrasound parameters were crown-rump length (CRL), mean gestational sac diameter (MGSD), yolk sac diameter (YSD), and the sum of the differences between gestational ages and embryonic heart rate (EHR). Potential predictors for spontaneous miscarriage occurring prior to 20 weeks were evaluated.Results:Fifty-three (12.8%) patients had miscarriages and 362 (87.2%) had normal outcomes. Forty-three (81.2%) miscarriages occurred in the first trimester, 5 (9.4%) in the second trimester, and 5 (9.4%) represented fetal anomalies. EHR, CRL, and MGSD were decreased in the miscarriage group (p<0.001); YSD showed no difference (p=0.21). Gestational age by CRL and by MGSD were different between the groups (p<0.001). The proposed sum of differences was higher in the miscarriage group (p<0.001). Maternal age, indication for scan, gestational age by MGSD and CRL, heart rate, and proposed sum of differences were found to be potential predictors. Predictive ability of our proposed model was calculated sensitivity as 0.509, and specificity as 0.975 with a cut-off=0.5. The prediction model’s false positive rate is 0.025, and its false negative rate is 0.491.Conclusions:Miscarriage can be predicted via maternal characteristics and ultrasound findings. Advancing maternal age, low EHR, and high proposed sum of differences increase the probability of miscarriage.
前言:根据妊娠早期超声检查结果和产妇特征,建立单胎妊娠妇女流产的预测模型。材料和方法:对415例单胎妊娠进行前瞻性横断面研究。初始超声参数为冠臀长(CRL)、平均胎囊直径(MGSD)、卵黄囊直径(YSD)、胎龄与胚胎心率(EHR)差值之和。评估妊娠20周前自然流产的潜在预测因素。结果:流产53例(12.8%),正常362例(87.2%)。43例(81.2%)流产发生在妊娠早期,5例(9.4%)发生在妊娠中期,5例(9.4%)为胎儿异常。流产组EHR、CRL、MGSD降低(p<0.001);YSD差异无统计学意义(p=0.21)。CRL和MGSD的胎龄组间差异有统计学意义(p<0.001)。流产组的建议差异和更高(p<0.001)。发现产妇年龄、扫描指征、MGSD和CRL的胎龄、心率和建议的差异总和是潜在的预测因素。我们提出的模型的预测能力计算灵敏度为0.509,特异性为0.975,截断值为0.5。预测模型的假阳性率为0.025,假阴性率为0.491。结论:可通过产妇特征和超声检查预测流产。高龄产妇、低EHR和高建议差异增加流产的可能性。
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引用次数: 3
To evaluate the role of Gabapentin as preemptive analgesic in patients undergoing total abdominal hysterectomy in spinal anesthesia 目的评价加巴喷丁在腰麻下腹式全子宫切除术患者中作为先发制人镇痛药的作用
Pub Date : 2016-12-03 DOI: 10.29333/EJGM/81758
U. Bhatia, Mona Panchal, N. Gupta
Introduction:Preemptive analgesia is an antinociceptive treatment that prevents establishment of altered processing of afferent input. Gabapentin, a structural analogue of gamma-amino butyric acid, has been used as an anticonvulsant and antinociceptive drug and is claimed to be more effective in preventing neuropathic component of acute nociceptive pain of surgery.Material and Methods:Fifty patients of ASA grade I and II were assigned to receive oral 600mg Gabapentin or Placebo 2 hours before surgery. Surgeries were conducted under spinal anesthesia. Post operatively pain was assessed by visual analogue score (VAS) at 2, 4, 8, 12 and 24 hrs. Patients were given rescue analgesic on demand. Sedation score and total numbers of analgesics during first 24 hours postoperatively were noted.Results:Gabapentin group resulted in faster onset of motor and sensory block, significantly longer duration of analgesia, substantial reduction in post-operative pain and the rescue analgesics. Patients remained in sleeping but co- operative state and Gabapentin group were not associated with side effects when compared with placebo group.Conclusions:Preemptive use of Gabapentin 600mg orally significantly prolongs the analgesia with reducing postoperative pain and rescue analgesics in patients undergoing total abdominal hysterectomy under spinal anesthesia.
简介:先发制人的镇痛是一种抗感觉性治疗,防止传入输入的改变加工的建立。加巴喷丁是γ -氨基丁酸的结构类似物,已被用作抗惊厥和抗痛觉性药物,据称在预防手术急性痛觉性疼痛的神经病变成分方面更有效。材料与方法:50例ASA I级和II级患者术前2小时口服加巴喷丁600mg或安慰剂。手术在脊髓麻醉下进行。术后2、4、8、12、24小时采用视觉模拟评分(VAS)评估疼痛。患者按需给予抢救镇痛药。记录术后24小时镇静评分及镇痛药总剂量。结果:加巴喷丁组患者运动和感觉阻滞发作更快,镇痛持续时间明显延长,术后疼痛明显减轻,镇痛药物用量明显减少。与安慰剂组相比,加巴喷丁组患者仍处于睡眠但合作状态,且无副作用。结论:脊髓麻醉下腹式全子宫切除术患者,口服加巴喷丁600mg,可显著延长患者的镇痛时间,减轻术后疼痛,并可抢救镇痛。
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引用次数: 1
Carcinoid tumor of appendix; retrospective review of 1800 appendectomy patients 阑尾类癌;1800例阑尾切除术患者的回顾性分析
Pub Date : 2016-12-03 DOI: 10.29333/EJGM/81762
Orhan Yağmurkaya, E. Dikicier, G. Cakmak, H. Demir, N. Firat, R. Çapoğlu, Yener Uzunoğlu, F. Altıntoprak
Malignant tumors of the appendix are rare and the histopathological diagnosis can often be made in the postoperative period. The clinical records of 1800 patients who underwent surgery in emergency conditions with a preliminary diagnosis of acute appendicitis were reviewed retrospectively. Carcinoid tumor was detected in 7 patients (0.38%) on histopathological examination. Of these patients, 4 were male (57.1%), 3 were female (42.9) and the mean age was found to be 36 (22-49). Appendiceal carcinoid tumors are tumors with a good prognosis. Even though their prognosis is good, close monitoring of the patients is recommended due to the likelihood of the detection of a proportion (13-33%) of synchronous and/or metachronous colorectal cancer in the literature.
阑尾的恶性肿瘤是罕见的,通常可以在术后进行组织病理学诊断。本文回顾性分析了1800例初步诊断为急性阑尾炎的急诊手术患者的临床资料。组织病理学检查发现类癌7例(0.38%)。其中男性4例(57.1%),女性3例(42.9%),平均年龄36岁(22 ~ 49岁)。阑尾类癌是一种预后良好的肿瘤。尽管他们的预后良好,但由于文献中可能发现比例(13-33%)的同步和/或异时性结直肠癌,因此建议对患者进行密切监测。
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引用次数: 1
Oxidative stress biomarkers among Saudi patients withnon-alcoholic steatohepatitis versus chronic hepatitis C 沙特非酒精性脂肪性肝炎患者与慢性丙型肝炎患者的氧化应激生物标志物
Pub Date : 2016-12-03 DOI: 10.29333/ejgm/81755
O. Al-Jiffri
Introduction:As oxidative status may be an influential factor for increasing the progress of the disease and decreasing the effectiveness of the treatment, the aim of this study was to measure the oxidative stress and anti-oxidative markers among Saudi patients with chronic hepatitis C (CHC) versus nonalcoholic steatohepatitis (NASH).Material and Methods:This study was carried out on a sample of 150 consecutive patients (75 with CHC and 75 with NASH), selected from gastroenterology outpatient clinic, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Also, this study included 75 healthy volunteers, mostly, relatives of the patients who came with them to the clinic. Measurements of oxidative stress and anti-oxidative stress markers were measured for all participants.Results:The mean values of oxidative stress markers included conjugated dienes (CD), malondialdehyde (MDA), nitric oxide (NO) and myeloperoxidase (MPO) were significantly elevated in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly elevated in patients with NASH than patients with CHC. However, the mean values of anti-oxidative stress markers include glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione (GSH), arylesterase (AE) and paraoxonase (PON) were significantly reduced in patients with CHC and patients with NASH when compared with Healthy controls group. Also, these parameters were significantly reduced in patients with NASH than patients with CHC.Conclusions:In this study, patients with NASH have higher levels of oxidative and lower anti-oxidant markers than patients with CHCs.
由于氧化状态可能是增加疾病进展和降低治疗有效性的一个影响因素,本研究的目的是测量沙特慢性丙型肝炎(CHC)患者与非酒精性脂肪性肝炎(NASH)患者的氧化应激和抗氧化标志物。材料和方法:本研究选取了来自沙特阿拉伯吉达阿卜杜勒阿齐兹国王大学医院消化科门诊的150例连续患者(75例CHC和75例NASH)作为样本。此外,这项研究还包括75名健康的志愿者,其中大多数是与他们一起来到诊所的患者的亲属。测量所有参与者的氧化应激和抗氧化应激标志物。结果:CHC和NASH患者的氧化应激标志物包括共轭二烯(CD)、丙二醛(MDA)、一氧化氮(NO)和髓过氧化物酶(MPO)的平均值与健康对照组相比显著升高。此外,NASH患者的这些参数明显高于CHC患者。然而,CHC和NASH患者抗氧化应激标志物谷胱甘肽过氧化物酶(GPx)、超氧化物歧化酶(SOD)、谷胱甘肽(GSH)、芳基酯酶(AE)和对氧磷酶(PON)的平均值与健康对照组相比均显著降低。此外,NASH患者的这些参数明显低于CHC患者。结论:在本研究中,NASH患者的氧化标志物水平高于CHCs患者,而抗氧化标志物水平较低。
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引用次数: 3
The control of the port site bleedings with Foley catheterin obese patients Foley导管对肥胖患者肝部位出血的控制
Pub Date : 2016-12-03 DOI: 10.29333/EJGM/81759
K. Gemici, A. Okuş, Y. Tanrıkulu
The control of port site bleedings (PSB) is particularly difficult in obese patients. PSB can lead to morbidity via inhibiting the minimally invasive features of laparoscopic surgery such as the increase in the incision size. PSB can be controlled by Foley catheter. PSB has been observed in four patients with body mass index >35 and the bleeding cannot be prevented with different hemostasis techniques (for instance cauterization, etc.). Bleeding can be controlled upon placing the Foley catheter and then the balloon was inflated and putting it to the traction in the port site. Umbilical cord clamp was used instead of traditional methods for traction. In addition to the hemostatic effect of traction, the effect of compression of the umbilical clamp contributed to hemostasis. Catheter was removed after 24-36 hours. Bleeding did not occur again upon the usage of Foley catheter in these patients. Foley catheter traction is an easy and efficient hemostatic technique in patients with PSB.
在肥胖患者中,控制肝部位出血(PSB)尤其困难。PSB可通过抑制腹腔镜手术的微创特征(如切口大小的增加)而导致发病。可通过Foley导管控制PSB。4例体重指数为bbb35的患者出现PSB,采用不同的止血方法(如烧灼等)均不能预防出血。在放置Foley导管后,可以控制出血,然后将气球充气并将其放在端口处的牵引处。采用脐带钳代替传统的牵引方法。除了牵引的止血作用外,脐带钳的压迫作用也有助于止血。24-36小时后拔除导管。这些患者在使用Foley导管后未再发生出血。Foley导尿管牵引是一种简单有效的止血技术。
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引用次数: 1
Association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency 肥胖伴有维生素D缺乏症的沙特2型糖尿病患者胰岛素抵抗与炎症细胞因子的关系
Pub Date : 2016-12-03 DOI: 10.29333/EJGM/81757
F. M. Al-Sharif
Introduction:Vitamin D deficiency is now considered a public health problem around the world that is strongly associated with all-cause and cardiovascular mortality. However, vitamin D deficiency may play a role in mediating low-grade inflammation and insulin resistance among type 2 diabetic patients.Material and Methods:One hundred obese Saudi patients with T2DM (60 males and 40 females). Their age was46.38 ± 7.53 year, and a control group included one hundred healthy volunteers, who was gender and age matched.Results:Obese T2DM patients showed significantly higher glucose, insulin, glycosylated hemoglobin (HBA1c), Homeostasis Model Assessment-Insulin Resistance (HOMA-IR) index, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and C-reactive protein(CRP) in addition to significantly lower values of the quantitative insulin-sensitivity check index (QUICKI) and 25(OH) vitamin D levels in comparison to controls. Serum levels of TNF-α , IL-6 and CRP showed an inverse relationship with QUICKI and a direct relationship with HOM-IR and HBA1c among obese Saudi type 2 diabetic with vitamin D deficiency.Conclusions:Within the limit of there is an association between insulin resistance and inflammatory cytokines among obese Saudi type 2 diabetic with vitamin D deficiency.
维生素D缺乏现在被认为是世界范围内的一个公共卫生问题,与全因死亡率和心血管死亡率密切相关。然而,维生素D缺乏可能在2型糖尿病患者中介导低级别炎症和胰岛素抵抗中发挥作用。材料与方法:沙特肥胖T2DM患者100例(男性60例,女性40例)。年龄46.38±7.53岁,性别、年龄相匹配的健康志愿者100名作为对照组。结果:肥胖T2DM患者血糖、胰岛素、糖化血红蛋白(HBA1c)、稳态模型评估-胰岛素抵抗(HOMA-IR)指数、白细胞介素-6 (IL-6)、肿瘤坏死因子-α (TNF-α)和c反应蛋白(CRP)水平显著高于对照组,胰岛素敏感性定量检查指数(QUICKI)和25(OH)维生素D水平显著低于对照组。沙特肥胖合并维生素D缺乏症的2型糖尿病患者血清TNF-α、IL-6和CRP水平与QUICKI呈反比关系,与homa - ir和HBA1c呈直接关系。结论:在研究范围内,肥胖伴有维生素D缺乏症的沙特2型糖尿病患者的胰岛素抵抗和炎症细胞因子之间存在关联。
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引用次数: 4
Femoral nerve palsy due to Iliopsoas hematoma 髂腰肌血肿所致股神经麻痹
Pub Date : 2016-12-03 DOI: 10.29333/EJGM/81760
Metin Gürel, O. Eser, E. Sari, Akif Sönmez
Femoral nerve palsy seconder to iliacus hematoma has been rarely reported in terms of blood coagulation abnormalities, either from anticoagulant medications or from hemophilia. The clinical symptoms vary from femoral neuropathy to fatal hypovolemic shock with increased used of anticoagulant agents; femoral nerve palsy subsequent to hemorrhage within the iliopsoas muscle has become a frequent clinical problem. In our case, a 73-year-old male patient presented to hospital with left leg pain and weakness. Lumbar magnetic resonance imaging (MRI) and abdomen computed tomography (CT) showed a left-sided iliopsoas hematoma. An extraperitoneal inguinal incision (Gibson incision) was made. The hematoma was superior of the external iliac artery in the iliopsoas muscle. It was nearly 8 cm deep and was drained and evacuated. After the operation, the left leg pain decreased, and the weakness of left leg improved (3/5).
股神经麻痹继发于髂血肿,在抗凝药物或血友病引起的凝血异常方面很少有报道。临床症状从股神经病变到致命的低血容量性休克,抗凝剂的使用增加;股神经麻痹并发髂腰肌出血已成为临床常见的问题。在我们的病例中,一名73岁男性患者以左腿疼痛和虚弱来医院就诊。腰椎磁共振成像(MRI)和腹部计算机断层扫描(CT)显示左侧髂腰肌血肿。腹股沟腹膜外切口(Gibson切口)。血肿位于髂腰肌的髂外动脉上方。它近8厘米深,被排干并疏散。术后左腿疼痛减轻,左腿无力改善(3/5)。
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引用次数: 6
Subscapular skinfold thickness is a handy tool till body mass index in the evaluation of obesity 肩胛下皮褶厚度是体质指数评价肥胖的便捷工具
Pub Date : 2016-12-03 DOI: 10.29333/EJGM/81761
F. Armutcu, Ş. Aras, Seyfettin Üstünsoy
The most commonly used anthropometric measurement to diagnose obesity is the body mass index (BMI), which is calculated as weight in kilograms divided by height in meters squared. However, the use of BMI has limitations, because it does not distinguish between fat mass and muscle or identity the distribution of body fat. The aim of this brief report was to compare clinical assessment of obesity with measurements obtained using BMI and subscapular skinfold thickness (SST). According to our study results and present report, we observed that female adults with excess body weight had higher SST which is a handy indicator for obesity evaluation.
诊断肥胖最常用的人体测量方法是体重指数(BMI),其计算方法是体重(公斤)除以身高(米)的平方。然而,BMI的使用有局限性,因为它不能区分脂肪量和肌肉,也不能识别身体脂肪的分布。这篇简短报告的目的是比较肥胖的临床评估与BMI和肩胛下皮褶厚度(SST)的测量结果。根据我们的研究结果和本报告,我们观察到体重过重的成年女性具有较高的SST,这是一个方便的肥胖评估指标。
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引用次数: 4
A Common Health Problem in Children: Tracheobronchial Foreign Body Aspirations 儿童常见的健康问题:气管支气管异物吸入
Pub Date : 2016-08-06 DOI: 10.29333/EJGM/81895
B. Altuntas, Y. Aydın, I. İnce, A. Eroğlu
Introduction:Tracheobronchial foreign body aspiration is serious health problem in children. In this paper, we aimed to present our experience in tracheobronchial foreign body aspirations and rigid bronchoscopy in children.Material and Methods:Between January 1990 and May 2015, 693 patients less than 17 years of age with presumptive diagnosis of tracheobronchial aspiration of foreign bodies were included this study. Patients records were retrospectively analysed according to age, gender, symptoms and physical fndings, foreign body type and localization, radiologic fndings and treatments.Results:Three hundred ffty one of the patients were male (51%) and 342 patients were female (49%). All patients underwent rigid bronchoscopy procedure except six patients. Foreign bodies were found in 589 patients (85%). Mcgill clemp was used for removing of foreign bodies settled on vocal cords in six patients and subsequently, rigid bronchoscopy was performed for checking of tracheobronchial system. Thoracotomy was required in four patients (0.7%). The most common foreign bodies were nuts (n=373). The most frequent localization site of foreign bodies was right bronchial system (n=292). The chief radiologic fnding was obstructive emphysema (n=296). Cardiopulmonary arrest occurred in 11 patients and 2 of them died (0,3%).Conclusions:The gold standard in diagnosis and management of tracheobronchial foreign body aspiration is bronchoscopy, which can be performed with a low complication rate.
气管支气管异物吸入是儿童严重的健康问题。在本文中,我们的目的是介绍我们的经验气管支气管异物吸入和刚性支气管镜检查在儿童。材料与方法:1990年1月至2015年5月,693例17岁以下推定诊断为气管支气管异物吸入的患者纳入本研究。根据年龄、性别、症状和体格表现、异物类型和定位、放射学表现和治疗方法对患者记录进行回顾性分析。结果:男性351例(51%),女性342例(49%)。除6例患者外,所有患者均行刚性支气管镜检查。589例(85%)患者发现异物。6例患者使用Mcgill钳清除声带异物,随后行刚性支气管镜检查气管支气管系统。4例(0.7%)患者需要开胸手术。最常见的异物是坚果(n=373)。最常见的异物定位部位为右支气管系统(n=292)。主要影像学表现为阻塞性肺气肿(n=296)。11例患者发生心肺骤停,2例死亡(0.3%)。结论:气管支气管异物吸入诊断和处理的金标准是支气管镜检查,其并发症发生率低。
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引用次数: 0
The evaluation of asthma and COPD patients in emotional status: A cross-sectional study. 评估哮喘和COPD患者的情绪状态:一项横断面研究。
Pub Date : 2016-08-06 DOI: 10.29333/EJGM/81897
Y. Aydemir, A. C. Güngen, Belma Doğan-Güngen, Yeşim Guzey-Aras, Aysun Şengül
Introduction:Psychiatric comorbidities are prevalent in patients with chronic respiratory diseases. But, there is no clear evidence comparing asthma and COPD. The aim of the present study was to investigate and compare the emotional status of patients with asthma and COPDMaterial and Methods:The study included 132 consecutive patients who were diagnosed with asthma (n=78) and COPD (n=54) who did not receive therapy for pshiciatric disorders. Emotional status were evaluated using the Beck and Hamilton surveys.Results:There was signifcant difference between patients asthma an COPD in terms of anxiety and depression level. The patients with COPD achieved signifcantly worse scores in emotional status. Anxiety and depression was signifcantly greater in patients with uncontrolled asthma. But, there was no signifcant correlation between GOLD stages and spirometric values and emotional disorders in COPD patients.Conclusions:It was concluded that anxiety and depression are prevalent in patients with COPD and particularly uncontrolled asthma, and patients with such chronic diseases; psychosocial support may be helpful, alongside the treatment of existing disease.
精神合并症在慢性呼吸系统疾病患者中普遍存在。但是,没有明确的证据比较哮喘和慢性阻塞性肺病。本研究的目的是调查和比较哮喘和慢性阻塞性肺病患者的情绪状态。材料和方法:本研究纳入了132例连续诊断为哮喘(n=78)和慢性阻塞性肺病(n=54)的患者,这些患者未接受精神障碍治疗。使用贝克和汉密尔顿的调查来评估情绪状态。结果:哮喘患者与COPD患者在焦虑、抑郁水平上存在显著差异。COPD患者的情绪状态得分明显较差。不受控制的哮喘患者的焦虑和抑郁程度明显更高。但是,COPD患者的GOLD分期、肺活量值和情绪障碍之间无显著相关性。结论:焦虑和抑郁在慢性阻塞性肺病患者中普遍存在,尤其是未控制的哮喘患者;在治疗现有疾病的同时,社会心理支持可能会有所帮助。
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引用次数: 1
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European journal of general medicine
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