S. Sag, O. F. Nas, A. Ozturk, D. Yeşilbursa, C. Erdoğan
This report describes a case of spontaneously developing bilateral perirenal fluid accumulation in a patient under monitoring for tetralogy of Fallot. The causal pathophysiology of perirenal fluid accumulation in patients with tetralogy of Fallot is unidentified. As a result of comprehensive examinations we establish that perirenal fluid develops due to high hematocrit. Perirenal fluid did not relapse after repeated phlebotomy treatment. Our case is the first to describe the combination of tetralogy of Fallot and perirenal fluid accumulation in the literature
{"title":"Bilateral perirenal fluid accumulation associated with tetralogy of fallot","authors":"S. Sag, O. F. Nas, A. Ozturk, D. Yeşilbursa, C. Erdoğan","doi":"10.29333/EJGM/81892","DOIUrl":"https://doi.org/10.29333/EJGM/81892","url":null,"abstract":"This report describes a case of spontaneously developing bilateral perirenal fluid accumulation in a patient under monitoring for tetralogy of Fallot. The causal pathophysiology of perirenal fluid accumulation in patients with tetralogy of Fallot is unidentified. As a result of comprehensive examinations we establish that perirenal fluid develops due to high hematocrit. Perirenal fluid did not relapse after repeated phlebotomy treatment. Our case is the first to describe the combination of tetralogy of Fallot and perirenal fluid accumulation in the literature","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86220168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obesity is a major risk factor for renal disease and can cause de novo glomerulopathy. The characteristic finding of obesity-induced renal injury includes glomerular hypertrophy, glomerular basement membrane thickening, mesangial matrix expansion, and increased renal inflammation. These changes may lead to albuminuria, a progressive impairment of renal function, glomerulosclerosis and tubulointerstitial fibrosis. The mechanisms of obesity-related glomerulopathy (ORG) are not well understood however, several mechanisms acting singly or in combination have been suggested as excess excretory load, excess renal sodium retention and insulin resistance (IR) and hyperinsulinemia, increased monocyte chemoattractant protein 1 (MCP-1) expression, Lipotoxicity in proximal tubular cells, increased inflammatory cytokine production such as Interleukin (IL) IL-6, IL-1, and tumor necrosis factor (TNF-α). Activation of NFκB transcription, increase Leptin levels, reduction in plasma adiponectin expression with its anti-inflammatory effects, decrease nitric oxide (NO) level, increase reactive oxygen species (ROS) generation, Hyperlipidemia, and increases in plasma renin activity, angiotensinogen, angiotensin-converting enzyme activity, and circulating AngII. Many lines of treatment are suggested for ORG as Peroxisome proliferator-activated receptors (PPAR) Agonistic, Statins, anti-inflammatory therapy, and antioxidants are under trial. Weight loss decreases of proinflammatory factors, increase of anti-inflammatory molecules and reduces oxidative stress state in obesity, which may protect renal function. This review discusses recent data about ORG, the characteristics of pathogens and possible interventions to prevent kidney injury in obesity.
{"title":"Obesity-Related Glomerulopathy","authors":"Waleed S. Mohamed","doi":"10.29333/EJGM/81886","DOIUrl":"https://doi.org/10.29333/EJGM/81886","url":null,"abstract":"Obesity is a major risk factor for renal disease and can cause de novo glomerulopathy. The characteristic finding of obesity-induced renal injury includes glomerular hypertrophy, glomerular basement membrane thickening, mesangial matrix expansion, and increased renal inflammation. These changes may lead to albuminuria, a progressive impairment of renal function, glomerulosclerosis and tubulointerstitial fibrosis. The mechanisms of obesity-related glomerulopathy (ORG) are not well understood however, several mechanisms acting singly or in combination have been suggested as excess excretory load, excess renal sodium retention and insulin resistance (IR) and hyperinsulinemia, increased monocyte chemoattractant protein 1 (MCP-1) expression, Lipotoxicity in proximal tubular cells, increased inflammatory cytokine production such as Interleukin (IL) IL-6, IL-1, and tumor necrosis factor (TNF-α). Activation of NFκB transcription, increase Leptin levels, reduction in plasma adiponectin expression with its anti-inflammatory effects, decrease nitric oxide (NO) level, increase reactive oxygen species (ROS) generation, Hyperlipidemia, and increases in plasma renin activity, angiotensinogen, angiotensin-converting enzyme activity, and circulating AngII. Many lines of treatment are suggested for ORG as Peroxisome proliferator-activated receptors (PPAR) Agonistic, Statins, anti-inflammatory therapy, and antioxidants are under trial. Weight loss decreases of proinflammatory factors, increase of anti-inflammatory molecules and reduces oxidative stress state in obesity, which may protect renal function. This review discusses recent data about ORG, the characteristics of pathogens and possible interventions to prevent kidney injury in obesity.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81121605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ebru Fındıklı, S. Ateş, B. Kandemir, M. Karaaslan, M. Camkurt, F. İzci, Y. Durduran, Selçuk Kardaş, M. Bitirgen
Introduction:To evaluate the personality and temperament traits in patients with chronic hepatitis B in comparison to healthy subjects and to determine whether there is a relation between personality trait and level of anxiety or depression.Material and Methods:This was a case-control study in which 67 patients who had been under follow-up with diagnosis of chronic hepatitis B and 103 aged-matched healthy subjects were included. Study participants were asked to complete three self-report questionnaires— Temperament and Character Inventory (TCI) to define personality traits, Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) to evaluate presence and severity of depression and anxiety.Results:Total and sub-scale scores of five out of seven dimensions of TCI—reward dependence, persistence, self-directedness, cooperativeness, and self-transcence—were significantly higher in Group 1 than Group 2. Total BDI and BAI scores were significantly higher in Group 1 than Group 2 .Significantly more patients had a BDI score of 17 or over in Group 1 than Group 2. There was no significant correlation between total scores of TCI dimensions and total BAI or BDI scores except weak correlations between harm avoidance or self-directedness and total BAI or BDI scores.Conclusions:In terms of personality trait, patients with chronic hepatitis B exhibit higher reward dependence, persistence, self-directedness, cooperativeness, and self-transcendence from healthy population. The personality traits of patients should be considered during the management of hepatitis B in order to optimize treatment outcome and to prevent development of new mental health problems during the course of the disease.
{"title":"A case-control study on the temperament and Psychological mood of patients with chronic Hepatitis B","authors":"Ebru Fındıklı, S. Ateş, B. Kandemir, M. Karaaslan, M. Camkurt, F. İzci, Y. Durduran, Selçuk Kardaş, M. Bitirgen","doi":"10.29333/EJGM/81887","DOIUrl":"https://doi.org/10.29333/EJGM/81887","url":null,"abstract":"Introduction:To evaluate the personality and temperament traits in patients with chronic hepatitis B in comparison to healthy subjects and to determine whether there is a relation between personality trait and level of anxiety or depression.Material and Methods:This was a case-control study in which 67 patients who had been under follow-up with diagnosis of chronic hepatitis B and 103 aged-matched healthy subjects were included. Study participants were asked to complete three self-report questionnaires— Temperament and Character Inventory (TCI) to define personality traits, Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) to evaluate presence and severity of depression and anxiety.Results:Total and sub-scale scores of five out of seven dimensions of TCI—reward dependence, persistence, self-directedness, cooperativeness, and self-transcence—were significantly higher in Group 1 than Group 2. Total BDI and BAI scores were significantly higher in Group 1 than Group 2 .Significantly more patients had a BDI score of 17 or over in Group 1 than Group 2. There was no significant correlation between total scores of TCI dimensions and total BAI or BDI scores except weak correlations between harm avoidance or self-directedness and total BAI or BDI scores.Conclusions:In terms of personality trait, patients with chronic hepatitis B exhibit higher reward dependence, persistence, self-directedness, cooperativeness, and self-transcendence from healthy population. The personality traits of patients should be considered during the management of hepatitis B in order to optimize treatment outcome and to prevent development of new mental health problems during the course of the disease.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75099062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Yuca, Y. Cesur, H. Çaksen, D. Arslan, C. Yılmaz, A. Kaya
Introduction:Hypernatraemia has serious complications such as brain injury, brain oedema and seizure. In this study, the incidence among children hospitalized hypernatremia, causes, development time, clinical features, and morbidity, and aimed to reveal the effect on mortality.Material and Methods:In this retrospective study, clinical and laboratory data from patients with hypernatremic were recorded. The study period was 33 months. The groups were separated into two groups; group I: Hypernatremia was present at hospital admission, group II: Hypernatremia was acquared after the hospitalization.Results:Overall incidence of hypernatraemia was 1.3% of all hospitalised children. While 42% of patients were from group I, 58% of patients had acquired hypernatremia during hospital stay. In group I, 61% of patients had infections on hospital admission. The most common cause of hypernatraemia in group II was neurological disorders (53%). The mortality rate was 30.5% (11/36) in patients with hypernatraemia on admission, 67.3% (33/49) in those with hospital-acquired hypernatraemia (P 0.05.Conclusions:Hypernatraemia in pediatric age is associated with mortality and morbidity, and should be closely monitored in pediatric patients hospitalized for any reason in order to prevent complication.
{"title":"Hypernatremia in hospitalized children","authors":"S. Yuca, Y. Cesur, H. Çaksen, D. Arslan, C. Yılmaz, A. Kaya","doi":"10.29333/EJGM/81888","DOIUrl":"https://doi.org/10.29333/EJGM/81888","url":null,"abstract":"Introduction:Hypernatraemia has serious complications such as brain injury, brain oedema and seizure. In this study, the incidence among children hospitalized hypernatremia, causes, development time, clinical features, and morbidity, and aimed to reveal the effect on mortality.Material and Methods:In this retrospective study, clinical and laboratory data from patients with hypernatremic were recorded. The study period was 33 months. The groups were separated into two groups; group I: Hypernatremia was present at hospital admission, group II: Hypernatremia was acquared after the hospitalization.Results:Overall incidence of hypernatraemia was 1.3% of all hospitalised children. While 42% of patients were from group I, 58% of patients had acquired hypernatremia during hospital stay. In group I, 61% of patients had infections on hospital admission. The most common cause of hypernatraemia in group II was neurological disorders (53%). The mortality rate was 30.5% (11/36) in patients with hypernatraemia on admission, 67.3% (33/49) in those with hospital-acquired hypernatraemia (P 0.05.Conclusions:Hypernatraemia in pediatric age is associated with mortality and morbidity, and should be closely monitored in pediatric patients hospitalized for any reason in order to prevent complication.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78254874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Yazıcı, I. Guney, L. Altıntepe, A. Karagöz, S. Aslan
Main causes of drug-related antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis are antithyroid drugs. It is known that ANCA- positive vasculitis occurs after long term use of the drugs and develops in 4-6.5 percent of the patients. Herein, we present a female patient with propylthiouracil (PTU)-related ANCA- positive vasculitis, mimicking appendicitis and familial mediaterian fever (FMF), which developed after long-term drug usage.
{"title":"A case with drug-related ANCA-positive vasculitis","authors":"R. Yazıcı, I. Guney, L. Altıntepe, A. Karagöz, S. Aslan","doi":"10.29333/EJGM/81884","DOIUrl":"https://doi.org/10.29333/EJGM/81884","url":null,"abstract":"Main causes of drug-related antineutrophil cytoplasmic antibody (ANCA)-positive vasculitis are antithyroid drugs. It is known that ANCA- positive vasculitis occurs after long term use of the drugs and develops in 4-6.5 percent of the patients. Herein, we present a female patient with propylthiouracil (PTU)-related ANCA- positive vasculitis, mimicking appendicitis and familial mediaterian fever (FMF), which developed after long-term drug usage.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87343283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We read with a great interest an article entitled, «the effect of topical insulin application on wound healing» by Suleyman et al. (1). This article addresses an important issue of wound healing by topical application of insulin. With regards to this article we would like to bring forward some of the important issues which we have noticed while going through this article. In some earlier studies, insulin has been shown to enhance the extracellular matrix and collagen synthesis by increasing the proliferation of myofibroblasts during the stage of fibroplasia stimulating the action of macrophages and there by accelerates the process of wound healing (2, 3). Similar findings have also been observed by Suleyman et al. (1). Suleyman et al. (1) in their article have studied the effect of topical application of insulin on wound healing on fresh cutaneous wounds (without involving subcutaneous tissue) artificially created under aseptic conditions by using cautery in rats. These wounds were without any signs of infections. They found the faster and better wound healing following the topical application of insulin. In this connection, we would like to add further that wound healing is a complex and dynamic process that occurs in timely and orderly fashion, if not obstructed by repeated trauma, ischemia and infection. Particularly infection is the most important cause for non-healing of wounds. Presence of infectious agent in the wound affects each and every process involved in wound healing making it a non-healing wound. Hence, it would be interesting to study the effect of insulin on healing in infected wounds and chronic wounds to get more concrete and useful conclusions. Further the size of wound (10x4mm) was very small in their study. It would be more meaningful to study the effect of insulin on larger wounds with signs of infections. It has also been stated by Suleyman et al. (1) that insulin displays its effect during the acute phase wound healing by enabling the removal of necrotic tissues in the wound bed and preventing bacterial contamination, however in many earlier studies, topical application of insulin to chronic wounds and diabetic foot wounds has been found to yield equally good results (4, 5). One more important issue is absorption of insulin from wound and its effect on blood sugar level. Insulin is a most potent anti-diabetic agent known to reduce sugar level significantly. Hence, it is very essential to study the sugar levels and plasma insulin levels before and after the application of insulin to wounds. Suleyman et al. (1) have also observed that the rate of wound healing was found to be higher in the topical insulin group than the normal saline group, however, the period of complete wound closing was shorter than the insulin group (abstract lines 6 &7). These two statements appear to be contradictory. Also, no statistical tests have been applied at any stage of the study to prove the significance.
{"title":"Topical insulin and wound healing","authors":"B. Nagoba, Sarita B. Mantri, Baban D Adgaonkar","doi":"10.29333/EJGM/81885","DOIUrl":"https://doi.org/10.29333/EJGM/81885","url":null,"abstract":"We read with a great interest an article entitled, «the effect of topical insulin application on wound healing» by Suleyman et al. (1). This article addresses an important issue of wound healing by topical application of insulin. With regards to this article we would like to bring forward some of the important issues which we have noticed while going through this article. In some earlier studies, insulin has been shown to enhance the extracellular matrix and collagen synthesis by increasing the proliferation of myofibroblasts during the stage of fibroplasia stimulating the action of macrophages and there by accelerates the process of wound healing (2, 3). Similar findings have also been observed by Suleyman et al. (1). Suleyman et al. (1) in their article have studied the effect of topical application of insulin on wound healing on fresh cutaneous wounds (without involving subcutaneous tissue) artificially created under aseptic conditions by using cautery in rats. These wounds were without any signs of infections. They found the faster and better wound healing following the topical application of insulin. In this connection, we would like to add further that wound healing is a complex and dynamic process that occurs in timely and orderly fashion, if not obstructed by repeated trauma, ischemia and infection. Particularly infection is the most important cause for non-healing of wounds. Presence of infectious agent in the wound affects each and every process involved in wound healing making it a non-healing wound. Hence, it would be interesting to study the effect of insulin on healing in infected wounds and chronic wounds to get more concrete and useful conclusions. Further the size of wound (10x4mm) was very small in their study. It would be more meaningful to study the effect of insulin on larger wounds with signs of infections. It has also been stated by Suleyman et al. (1) that insulin displays its effect during the acute phase wound healing by enabling the removal of necrotic tissues in the wound bed and preventing bacterial contamination, however in many earlier studies, topical application of insulin to chronic wounds and diabetic foot wounds has been found to yield equally good results (4, 5). One more important issue is absorption of insulin from wound and its effect on blood sugar level. Insulin is a most potent anti-diabetic agent known to reduce sugar level significantly. Hence, it is very essential to study the sugar levels and plasma insulin levels before and after the application of insulin to wounds. Suleyman et al. (1) have also observed that the rate of wound healing was found to be higher in the topical insulin group than the normal saline group, however, the period of complete wound closing was shorter than the insulin group (abstract lines 6 &7). These two statements appear to be contradictory. Also, no statistical tests have been applied at any stage of the study to prove the significance.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83632703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background & Objective: Chronic B viral hepatitis is a major health problem worldwide. Several studies have reported that obesity is important risk factors altered immune system response in individuals with no underlying causes of liver disease. This study was to examine the correlation between body mass index, serum alanine aminotransferase activity and immunologic response in obese hepatitis B Saudi patients. Subjects and Methods: One hundred fifty Saudi male patients with hepatitis B viral infection (HBV); their age ranged from 30 to 45 (38.64 ± 7.12) years. Patients were divided in to two equal groups according to their body mass index: Group (A): Included patients with HBV, their body mass index (BMI) was greater than 30 kg/m2 (the obese group). Group (B): Included patients with HBV, their BMI between 20 and 24 kg/m2 (the normal-weight group). Results: An elevation of serum alanine aminotransferase (ALT) activity was found to be associated with increased BMI, also we observed an elevation with regard to the normal weight group in the parameters of white blood cells, neutrophils, monocytes, CD3, CD4 and CD8 for group A. CD3, CD4 and CD8 correlated with BMI only as a total amount, as well as with all measured parameters of blood count. Conclusion: Obesity adversely affects the immunological response and rate of disease progression in HBeAg-negative chronic hepatitis B viral infection. Body weight control is important in the management of patients with chronic hepatitis B viral infection.
{"title":"Correlation between serum alanine aminotransferase activity and immunologic response and body mass index in obese patients with chronic hepatitis B virus infection","authors":"F. M. Al-Sharif","doi":"10.29333/EJGM/81879","DOIUrl":"https://doi.org/10.29333/EJGM/81879","url":null,"abstract":"Background & Objective: Chronic B viral hepatitis is a major health problem worldwide. Several studies have reported that obesity is important risk factors altered immune system response in individuals with no underlying causes of liver disease. This study was to examine the correlation between body mass index, serum alanine aminotransferase activity and immunologic response in obese hepatitis B Saudi patients. Subjects and Methods: One hundred fifty Saudi male patients with hepatitis B viral infection (HBV); their age ranged from 30 to 45 (38.64 ± 7.12) years. Patients were divided in to two equal groups according to their body mass index: Group (A): Included patients with HBV, their body mass index (BMI) was greater than 30 kg/m2 (the obese group). Group (B): Included patients with HBV, their BMI between 20 and 24 kg/m2 (the normal-weight group). Results: An elevation of serum alanine aminotransferase (ALT) activity was found to be associated with increased BMI, also we observed an elevation with regard to the normal weight group in the parameters of white blood cells, neutrophils, monocytes, CD3, CD4 and CD8 for group A. CD3, CD4 and CD8 correlated with BMI only as a total amount, as well as with all measured parameters of blood count. Conclusion: Obesity adversely affects the immunological response and rate of disease progression in HBeAg-negative chronic hepatitis B viral infection. Body weight control is important in the management of patients with chronic hepatitis B viral infection.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84025370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martín l Becerril-Ángel, J. J. Castillo-Pérez, Á. Montiel-Jarquín, A. Villatoro-Martínez, Eugenio García Cano
The final step for an investigation to be completed is its communication in the international scientific forum. The aim of this paper is to highlight the general aspects of the submission of a scientific manuscript, those that are often faced by young and experienced researchers. It is true that a formal training for a scientific career does not exist, the courses taught in the graduate programs are not sufficient to know the process to publish scientific papers. A manuscript evaluation by an editor is based on the recommendations from reviewers, therefore we consider important the knowledge for preparation of a letter of submission, how to respond to publishers and/or reviewers and all the additional knowledge necessary to register a paper to a scientific journal.
{"title":"Aspects of the submission of articles to scientific journals","authors":"Martín l Becerril-Ángel, J. J. Castillo-Pérez, Á. Montiel-Jarquín, A. Villatoro-Martínez, Eugenio García Cano","doi":"10.29333/EJGM/81882","DOIUrl":"https://doi.org/10.29333/EJGM/81882","url":null,"abstract":"The final step for an investigation to be completed is its communication in the international scientific forum. The aim of this paper is to highlight the general aspects of the submission of a scientific manuscript, those that are often faced by young and experienced researchers. It is true that a formal training for a scientific career does not exist, the courses taught in the graduate programs are not sufficient to know the process to publish scientific papers. A manuscript evaluation by an editor is based on the recommendations from reviewers, therefore we consider important the knowledge for preparation of a letter of submission, how to respond to publishers and/or reviewers and all the additional knowledge necessary to register a paper to a scientific journal.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82463672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Bilir, D. C. Akkoyun, M. Aydın, Demet Ozkaramanli-Gur, H. Degi̇rmenci̇, N. Albayrak, Aydın Akyüz, Ş. Alpsoy, C. Koca, O. Erel
Introduction:Oxidative stress is among the major components of cardiovascular disease pathogenesis. Thiols play a significant role in prevention of oxidative stress in the cell. The purpose of this study is to investigate the relationship between the severity of coronary artery disease and disulphide/native thiol ratio, also determine if this ratio can be used as a marker of oxidative stress in this population.Material and Methods:A total number of 107 patients with angiographically established coronary artery disease and 26 control subjects with normal coronary arteries were enrolled. The mean Gensini score of patients were calculated (mean=30) and a score of 29 or below was considered as mild and a score of 30 or higher coronary artery disease as severe. Serum total, native thiol was measured and the disulphide and disulphide/native thiol ratio were calculated as described by Erel&Neselioglu.Results:Patients with mild and severe coronary artery disease had significantly lower native thiol levels and higher disulphide/native thiol ratio levels when compared to the control subjects. Also severe disease’s disulphide/native thiol ratio were higher than mild.Conclusions:The increased disulphide/native thiol ratio related with the severity of coronary artery disease, may reflect the augmented oxidative stress in coronary artery disease.
{"title":"Association of coronary artery disease severity and disulphide/native thiol ratio","authors":"B. Bilir, D. C. Akkoyun, M. Aydın, Demet Ozkaramanli-Gur, H. Degi̇rmenci̇, N. Albayrak, Aydın Akyüz, Ş. Alpsoy, C. Koca, O. Erel","doi":"10.29333/EJGM/81878","DOIUrl":"https://doi.org/10.29333/EJGM/81878","url":null,"abstract":"Introduction:Oxidative stress is among the major components of cardiovascular disease pathogenesis. Thiols play a significant role in prevention of oxidative stress in the cell. The purpose of this study is to investigate the relationship between the severity of coronary artery disease and disulphide/native thiol ratio, also determine if this ratio can be used as a marker of oxidative stress in this population.Material and Methods:A total number of 107 patients with angiographically established coronary artery disease and 26 control subjects with normal coronary arteries were enrolled. The mean Gensini score of patients were calculated (mean=30) and a score of 29 or below was considered as mild and a score of 30 or higher coronary artery disease as severe. Serum total, native thiol was measured and the disulphide and disulphide/native thiol ratio were calculated as described by Erel&Neselioglu.Results:Patients with mild and severe coronary artery disease had significantly lower native thiol levels and higher disulphide/native thiol ratio levels when compared to the control subjects. Also severe disease’s disulphide/native thiol ratio were higher than mild.Conclusions:The increased disulphide/native thiol ratio related with the severity of coronary artery disease, may reflect the augmented oxidative stress in coronary artery disease.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75440718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. El-Kader, Mohammed H. Saiem-Aldahr, O. Al-Jiffri
Introduction:Recent studies suggested that Hepatitis C Virus (HCV) patients may suffer from insulin resistance (IR), lipid profile abnormalities and poor virological response to the antiviral treatment. The beneficial effects of aerobic exercise have been a matter of controversy in the field of HCV management.This study aimed to measure the impact of aerobic exercise training on insulin resistance, lipid profile abnormalities and virological response in type 2 diabetic patients with chronic hepatitis C.Material and Methods:Eighty non-hypertensive, non-cirrhotic chronic HCV infection Saudi patients with high Triglycerides (TG), Total cholesterol (TC) and Low Density Lipoprotein Cholesterol (LDL-c) & non-insulin dependent diabetic with insulin resistance. Patients were divided in to two equal groups. The first group received aerobic exercise training, three sessions per week for three months in addition to their antiviral treatment. The second group (B) received only their antiviral treatment.Results:The mean values of Homeostasis Model Assessment-Insulin Resistance- index (HOMA-IR), TC, LDL-c, TG, virologic response and Body Mass Index (BMI) were significantly decreased in group (A), where the mean value of High Density Lipoprotein Cholesterol (HDL-c) was significantly increased, while there were no significant changes in group (B) Also; there was a significant difference between both groups at the end of the study.Conclusions:Treadmill walking exercise training is an effective treatment policy to improve insulin resistance, lipid profile abnormalities and virological response in type 2 diabetic patients with chronic hepatitis C.
{"title":"Aerobic exercise training modulates biochemical parameters in type 2 diabetic patients with chronic hepatitis C","authors":"S. El-Kader, Mohammed H. Saiem-Aldahr, O. Al-Jiffri","doi":"10.29333/EJGM/81881","DOIUrl":"https://doi.org/10.29333/EJGM/81881","url":null,"abstract":"Introduction:Recent studies suggested that Hepatitis C Virus (HCV) patients may suffer from insulin resistance (IR), lipid profile abnormalities and poor virological response to the antiviral treatment. The beneficial effects of aerobic exercise have been a matter of controversy in the field of HCV management.This study aimed to measure the impact of aerobic exercise training on insulin resistance, lipid profile abnormalities and virological response in type 2 diabetic patients with chronic hepatitis C.Material and Methods:Eighty non-hypertensive, non-cirrhotic chronic HCV infection Saudi patients with high Triglycerides (TG), Total cholesterol (TC) and Low Density Lipoprotein Cholesterol (LDL-c) & non-insulin dependent diabetic with insulin resistance. Patients were divided in to two equal groups. The first group received aerobic exercise training, three sessions per week for three months in addition to their antiviral treatment. The second group (B) received only their antiviral treatment.Results:The mean values of Homeostasis Model Assessment-Insulin Resistance- index (HOMA-IR), TC, LDL-c, TG, virologic response and Body Mass Index (BMI) were significantly decreased in group (A), where the mean value of High Density Lipoprotein Cholesterol (HDL-c) was significantly increased, while there were no significant changes in group (B) Also; there was a significant difference between both groups at the end of the study.Conclusions:Treadmill walking exercise training is an effective treatment policy to improve insulin resistance, lipid profile abnormalities and virological response in type 2 diabetic patients with chronic hepatitis C.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90807275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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