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Role of genetics in the Primary Biliary Cirrhosis; withthe presentation of the three sisters 遗传学在原发性胆汁性肝硬化中的作用在三姐妹的介绍下
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81913
T. Temel, P. Yildiz, A. Özakyol
Objective:There is growing evidence of genetic susceptibility and environmental factors lead to primary biliary cirrhosis (PBC). In particular, family members of aninfected individual can have higher risk of developing PBC. Here we present two of three siblings who did not have any clinical symptoms.Case:Three siblings, who are 44, 53 and 51 years old respectively, were diagnosed as PBC. One of them excepted and the others were asymptomatic and the 44 yearsoldwomen has a known results of PBC such as icteric sclera, ascites, prolonged prothrombin time, elevated INR and splenomegaly. On the contrary, other two siblingdid not have symptoms associated with PBC but the screening tests diagnosed PBC.Discussion:In conclusion that familial PBC is not rare, that it is related to maternally inherited factors. PBC may be initially asymptomatic and therefore familyscreening is important in the early diagnosis and treatment.
目的:越来越多的证据表明遗传易感性和环境因素导致原发性胆汁性肝硬化(PBC)。特别是,受感染个体的家庭成员患PBC的风险更高。在这里,我们提出三个兄弟姐妹中的两个没有任何临床症状。病例:三个兄弟姐妹,分别为44岁,53岁和51岁,被诊断为PBC。其中一人例外,其他人无症状,44岁女性有已知的PBC结果,如黄疸巩膜,腹水,凝血酶原时间延长,INR升高和脾肿大。相反,另外两个兄弟姐妹没有与PBC相关的症状,但筛查试验诊断为PBC。讨论:总之,家族性PBC并不罕见,它与母亲遗传因素有关。PBC最初可能无症状,因此家族筛查在早期诊断和治疗中很重要。
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引用次数: 0
Nasopharyngeal Symptoms caused by Abnormal Inflation of the Endotracheal Tube in Patients undergoing Cervical Spine Surgery 颈椎手术患者气管内管异常膨胀引起的鼻咽症状
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81899
Á. Montiel-Jarquín, Luis Enrique Romero-Morales, R. Lopez, M. Dominguez-Cid, E. García-Cano, M. Romero-Figueroa, R. BARRAGÁN-HERVELLA
Background:Abnormal balloon inflation of the endotracheal tube can cause nasopharyngeal symptoms. The objective is to describe Signs and Symptoms caused by theAbnormal Insufflated Balloon of the Endotracheal Cannula on patients undergoing Cervical Spine Surgery under General Anesthesia.Methods:Descriptive study, 39 patients underwent cervical spine surgery under general anesthesia, all of them were older than 18 years old and ASA I and II. Thepressure balloon inflation of the endotracheal tube was measured by a manual manometer VBM Medizintechnik GmbH, measurements were made at the beginning ofthe procedure, and every hour during the transanesthetic period. The patients underwent a questionnaire about their symptoms on the recovery area and 24 hoursafter extubation.Results:39 patients, 59% men, 41% women. Average age was 47, minimum 15 – maximum 77, SD 14.26 years old. The average pressure balloon inflation at the momentof intubation was 30.7 mmHg and at the moment of extubation was 29.07 mmHg. The symptoms presented on the Recovery Care Unit and at 24 hours were: pain,inflammation, dysphagia, foreign body sensation.Conclusions:The pressure balloon inflation of the endotracheal cannula is important, because a pressure greater than 30mmHg produce symptoms. Changes on thepatient’s position produced variations on the balloon pressure; therefore, continuous monitorization of the pressure baloon must be done.
背景:气管内管异常球囊膨胀可引起鼻咽部症状。目的是描述在全身麻醉下颈椎手术患者气管插管球囊充气异常引起的体征和症状。方法:对39例全麻下颈椎手术患者进行描述性研究,患者年龄均大于18岁,均为ASA I、II级。气管内管的压力球囊膨胀量由VBM Medizintechnik GmbH的手动压力计测量,测量在手术开始时进行,在经麻醉期间每小时进行一次。患者在拔管后24小时和恢复区接受症状问卷调查。结果:39例患者,男性59%,女性41%。平均年龄47岁,最小15岁,最大77岁,平均年龄14.26岁。插管时平均气压球囊膨胀30.7 mmHg,拔管时平均气压球囊膨胀29.07 mmHg。在康复护理室和24小时时出现的症状是:疼痛、炎症、吞咽困难、异物感。结论:气管内插管压力球囊充气是重要的,因为压力大于30mmHg会产生症状。患者体位的变化导致球囊压力的变化;因此,必须对压力气球进行连续监测。
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引用次数: 0
Histopathologically TTF-1 and Calcitonin PositiveLaryngeal Typical Carcinoid Tumor with ElevatedSerum Calcitonin 组织病理学上TTF-1和降钙素阳性咽典型类癌伴血清降钙素升高
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81915
F. R. Tuncturk, L. Uzun, T. Zenginkinet, S. Ozkanlı, M. Kalcıoğlu
Even with 1% of the incidence, laryngeal neuroendocrine tumors are the second common tumors in larynx; as a subtype, typical carcinoid tumors are extremelyrare. We presented a case of laryngeal typical carcinoid tumor and we discussed diagnostic criteria and treatment of these tumors. A 57-year-old male with a 3months history of hoarseness was examined endoscopically and a laryngeal mass on left supraglottic area was seen. High levels of serum calcitonin were detected.The histopathological analysis of biopsy material was typical carcinoid tumor. Laryngeal tumor resection and left neck dissection were performed. The histopathologicresult was TTF 1 and calcitonin positive primer laryngeal typical carcinoid tumor with cervical lymphoid metastasis. Serum calcitonin level returned to normal levelspostoperatively. The distinction between laryngeal carcinoid tumors and metastasis of thyroid medullary carcinoma are difficult histopathologically. So, laryngealcarcinoid tumors should be kept in mind in these circumstances.
喉神经内分泌肿瘤的发病率仅为1%,是喉部第二大常见肿瘤;作为一种亚型,典型的类癌肿瘤极为罕见。本文报告一例喉部典型类癌,并讨论该类肿瘤的诊断标准及治疗方法。57岁男性,嗓音嘶哑3个月,经内窥镜检查发现左侧声门上区喉肿块。血清降钙素水平高。活检材料的组织病理学分析为典型的类癌。行喉部肿瘤切除及左颈清扫术。组织病理学结果为ttf1和降钙素引物阳性喉部典型类癌伴宫颈淋巴转移。术后血清降钙素水平恢复正常。喉类癌与甲状腺髓样癌转移的鉴别在病理组织学上是困难的。因此,在这些情况下,应注意喉类癌肿瘤。
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引用次数: 0
Sitting Buddha position: Sacral agenesis case 坐佛位:骶骨发育不全病例
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81914
O. Güvenç, I. Guler, A. Annagür
Sacral agenesis syndrome (Caudal regression syndrome) is a neural tube defect that is characterized by absence of the vertebral segment that constitutes the sacrum. Itis very rarely seen and generally develops sporadically. Its etiology is influenced by maternal diabetes, genetic factors, teratogenic agents and vascular hypo-perfusion.It is important to make a diagnosis in the prenatal period. This paper presents a newborn diagnosed with sacral agenesis as a case and discusses this disease in thelight of the latest literature information.
骶骨发育不全综合征(尾侧退化综合征)是一种神经管缺陷,其特征是构成骶骨的椎节缺失。它非常罕见,通常是零星发生的。其病因受母体糖尿病、遗传因素、致畸剂和血管灌注不足的影响。产前诊断是很重要的。本文报道一例新生儿骶骨发育不全的病例,并结合最新的文献资料对此病进行讨论。
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引用次数: 0
Factors Affecting Survival in Small Cell Lung Cancer 影响小细胞肺癌生存的因素
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81903
A. Sakin, Erhan Turgut, Muruvvet Aybek, Ahmet Usta, Özgür Koşan, K. Çelik, S. Ozturk, M. Koçer
Background:Small cell lung cancer (SCLC) constitutes about 15-25 % of lung cancers with high mortality rate. Herein we observed the effect of parameters at the timeof diagnosis to survival of cases with SCLC.Methods:We evaluated 65 patients who were followed up in our oncology department retrospectively.Results:Tumor location and stage at the time of diagnosis, smoking history, accompanying comorbidities, ECOG PS, laboratory parameters and treatments applied inpursuit were evaluated. 3-month survival rate of patients was 75.9%, 50.2% for 6-month, 21.4% for 1 year, and 5.5% for 2 years during follow up. ECOG PS and stagewere found statistically significant risk factors in model created to determine overall survival.Conclusion:Performance score at the time of diagnosis, stage and presence of liver metastasis are identified as prognostic factors for SCLC and of these factors arequite valuable to predict the clinical outcome.
背景:小细胞肺癌(SCLC)约占肺癌的15- 25%,死亡率高。在此,我们观察了诊断时的参数对SCLC患者生存的影响。方法:对我院肿瘤科随访的65例患者进行回顾性分析。结果:对诊断时肿瘤的位置和分期、吸烟史、伴随的合并症、ECOG PS、实验室参数和治疗方法进行评价。3个月生存率为75.9%,6个月生存率为50.2%,1年生存率为21.4%,2年生存率为5.5%。在确定总生存率的模型中,ECOG、PS和分期被发现具有统计学意义的危险因素。结论:诊断、分期及有无肝转移时的表现评分可作为SCLC的预后因素,这些因素对预测临床预后有重要价值。
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引用次数: 0
Aerobic exercise training modulates bone mineralstatus in patients with chronic obstructive pulmonarydisease 有氧运动训练调节慢性阻塞性肺疾病患者的骨矿物质状态
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81906
S. El-Kader, O. Al-Jiffri, Hussein O. Al-Jiffri
Background:Chronic obstructive pulmonary disease (COPD) appears to be associated with low bone mineral density (BMD) due to long-term use of corticosteroids as aresult patients with COPD are at risk for osteoporosis-related fractures and worsening pulmonary function.Objective:The present study aimed to measure the effects of treadmill walking exercises on bone mineral status in patients with COPD.Methods:Sixty patients with moderate COPD of both sexes, their age ranged from 45 to 58 years. Subjects were divided into two equal groups: training group (groupA) received aerobic exercise training on treadmill for six months, where the second group (B) was considered as a control group who received no exercise training. Theprogram consisted of three sessions per week for six months.Results:The results of this study indicated a significant increase in BMD of the lumbar spine & the radius and serum calcium & significant reduction in parathyroidhormone in group (A), while these changes were not significant in group (B).Also; there was a significant difference between both groups at the end of the study.Conclusion:Treadmill walking exercise training is an effective treatment policy to improve bone mineral status in patients with COPD.
背景:慢性阻塞性肺疾病(COPD)似乎与长期使用皮质类固醇导致的低骨密度(BMD)相关,因此COPD患者有骨质疏松性骨折和肺功能恶化的风险。目的:本研究旨在测量跑步机步行运动对COPD患者骨矿物质状态的影响。方法:60例慢性阻塞性肺病患者,性别不限,年龄45 ~ 58岁。研究对象被分为两组:训练组(a组)在跑步机上进行有氧运动训练6个月,第二组(B组)作为对照组,不进行任何运动训练。该项目包括每周三节课,持续六个月。结果:a组大鼠腰椎、桡骨骨密度、血钙、甲状旁腺激素均显著升高,B组大鼠无明显变化;在研究结束时,两组之间存在显著差异。结论:跑步机步行运动训练是改善慢性阻塞性肺病患者骨矿物质状态的有效治疗策略。
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引用次数: 1
Isolated omental panniculitis: two case reports and review of literature 孤立性大网膜炎:2例报告及文献复习
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81894
Sukru Tas, O. Cıkman, A. Ozdil, Y. Akgun, M. Karaayvaz
Isolated omental panniculitis (IOP), a rare form of acute abdominal syndrome, is defined as intraabdominal panniculitis that involves only omentum without extraabdominal fat necrosis, inflammatory bowel disease and pancreatitis. In the search made using PubMed English database, only 4 cases are determined with IOP. IOP is conceptually confused with idiopathic omental infarction (IOI). However, omental infarctions that are rare causes of acute abdominal syndromes were published by Bush for the first time in 1986 and less than 400 cases were reported. In this article we aimed to publish 2 IOP patients who applied with acute abdominal manifestation and were treated with laparoscopic omental resection to discuss the other 4 IOP cases comparing with IOP together with literature.
孤立性大网膜泛膜炎(IOP)是一种罕见的急性腹部综合征,定义为腹腔内泛膜炎,仅累及大网膜而不累及腹外脂肪坏死、炎症性肠病和胰腺炎。在PubMed英文数据库的检索中,只有4例被确定为IOP。IOP在概念上与特发性大网膜梗死(IOI)相混淆。然而,大网膜梗死是引起急性腹部综合征的罕见原因,布什于1986年首次发表,报道的病例不到400例。在本文中,我们拟发表2例因急腹症而应用腹腔镜网膜切除术治疗的IOP患者,并结合文献讨论其他4例IOP与IOP的比较。
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引用次数: 4
Inflammatory Biomarkers And Endothelial Dysfunction Among Obese Type 2 Diabetic Patients: A Correlational Study 肥胖2型糖尿病患者的炎症生物标志物和内皮功能障碍:一项相关研究
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81901
M. S. Al-dahr
Background:The vascular complications of diabetes mellitus impose a huge burden on the management of this disease. Inflammation is one of the major factors in theformation of endothelial dysfunction. Endothelial dysfunction is a major contributor to the complications of diabetes mellitus.Objective:The aim of the present study was to investigate the possible relationship between inflammation and endothelial dysfunction in obese type 2 diabeticpatients.Material and Methods:Forty obese type 2 diabetic patients (24 males and 16 females) with body mass index (BMI) ranged from 31 to 35 Kg/m2, non-smokers, freefrom respiratory, kidney; liver, metabolic and neurological disorders were recorded in this study. Their age ranged from 40 to 55 years were included in this study asthe first group (A). While a forty non-diabetic subjects (23 males and 17 females) not suffering of any disease, their age ranged from 40 to 52 years were included inthis study as the second group (B) and considered as a control group.Results:Diabetic patients showed significantly higher values of TNF-α, IL-6, CRP, HBA1c, ICAM-1, VCAM-1 and E-selectin in comparison to controls. Also, there wassignificant positive correlation between inflammatory and endothelial dysfunction biomarkers among obese diabetic patients.Conclusions:There was a strong association between elevated biomarkers of inflammation and endothelial dysfunction among type 2 diabetic patients.
背景:糖尿病的血管并发症给糖尿病的治疗带来了巨大的负担。炎症是内皮功能障碍形成的主要因素之一。内皮功能障碍是糖尿病并发症的主要原因。目的:本研究的目的是探讨肥胖2型糖尿病患者炎症与内皮功能障碍之间的可能关系。材料与方法:体重指数(BMI) 31 ~ 35kg /m2的肥胖2型糖尿病患者40例(男24例,女16例),不吸烟,无呼吸、无肾;本研究记录了肝脏、代谢和神经系统疾病。年龄在40 - 55岁之间的患者作为第一组(A), 40名无任何疾病的非糖尿病患者(男性23名,女性17名)作为第二组(B),年龄在40 - 52岁之间作为对照组。结果:与对照组相比,糖尿病患者的TNF-α、IL-6、CRP、HBA1c、ICAM-1、VCAM-1、E-selectin均显著升高。此外,肥胖糖尿病患者的炎症和内皮功能障碍生物标志物之间存在显著的正相关。结论:在2型糖尿病患者中,炎症生物标志物升高与内皮功能障碍之间存在很强的相关性。
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引用次数: 1
Effect of Robotic training on walking and balance inpatient with Hereditary Spastic Paraplegia 机器人训练对遗传性痉挛性截瘫患者行走及平衡能力的影响
Pub Date : 2018-01-06 DOI: 10.29333/EJGM/81909
I. Boyraz, Bunyamin Koc, Hakan Sarman, M. Ozdemir
Our patient was 22 years old and was being followed with pure Hereditary Spastic Paraplegia. He was provided with robot assisted-gait training combined withphysiotherapy. Robot-assisted gait training lasted 40 minutes per a day and 20 sessions training. enforced about 7 weeks and three times in a week. Strenghten,stretching and balance exercise were applied as physiotherapy every day. He was evealuated in terms of functional ambulation category, Medical Research Council(MRC) Scale for muscle strength, Modified Ashworth Scale (MAS), 6-minute walking test, 10-meter walking test, timed up and go, Berg Balance Scale before and aftertreatment.After the treatments, the patient could walk more confidently and speedy. Robotic training can contribute to physiotherapy as plus to improve patientwalking and balance.
我们的病人是22岁,被跟踪与纯遗传性痉挛性截瘫。他接受了机器人辅助步态训练和物理治疗。机器人辅助的步态训练持续了每天40分钟和20次训练。执行约7周,每周三次。每天进行强化、拉伸、平衡运动等物理治疗。根据功能活动类别、医学研究委员会(MRC)肌肉力量量表、改良Ashworth量表(MAS)、6分钟步行测试、10米步行测试、计时起床和走、Berg平衡量表对患者进行评估。经过治疗,病人可以更加自信和快速地行走。机器人训练有助于物理治疗,并能改善患者的行走和平衡能力。
{"title":"Effect of Robotic training on walking and balance inpatient with Hereditary Spastic Paraplegia","authors":"I. Boyraz, Bunyamin Koc, Hakan Sarman, M. Ozdemir","doi":"10.29333/EJGM/81909","DOIUrl":"https://doi.org/10.29333/EJGM/81909","url":null,"abstract":"Our patient was 22 years old and was being followed with pure Hereditary Spastic Paraplegia. He was provided with robot assisted-gait training combined with\u0000physiotherapy. Robot-assisted gait training lasted 40 minutes per a day and 20 sessions training. enforced about 7 weeks and three times in a week. Strenghten,\u0000stretching and balance exercise were applied as physiotherapy every day. He was evealuated in terms of functional ambulation category, Medical Research Council\u0000(MRC) Scale for muscle strength, Modified Ashworth Scale (MAS), 6-minute walking test, 10-meter walking test, timed up and go, Berg Balance Scale before and after\u0000treatment.After the treatments, the patient could walk more confidently and speedy. Robotic training can contribute to physiotherapy as plus to improve patient\u0000walking and balance.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80836400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on Asymptomatic Bacteriuria in Diabetic Individuals from Rural Area 农村糖尿病患者无症状菌尿的研究
Pub Date : 2018-01-04 DOI: 10.29333/EJGM/81765
M. Rastogi, M. Davane, B. Nagoba
{"title":"Studies on Asymptomatic Bacteriuria in Diabetic Individuals from Rural Area","authors":"M. Rastogi, M. Davane, B. Nagoba","doi":"10.29333/EJGM/81765","DOIUrl":"https://doi.org/10.29333/EJGM/81765","url":null,"abstract":"","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80902257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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European journal of general medicine
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