Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737414
Li Ma, Chenyang Jiang, Jintao Xiao, Kun Wang, Wei Xie, Bo Liu
Piezoelectric inchworm actuators have a wide application in the field of Nano positioning and ultra-precision detecting instruments which depend on the characteristics of large stroke, high resolution and rigidity, quick response speed, small size, high driving force, low power consumption, not being affected by electromagnetic interference, and so on. A new piezoelectric inchworm actuator based on the principle of flexible amplification is developed in this paper. In the moving mechanism of the actuator, its clamping mechanism adopts symmetrical lever amplification structure, and its middle drive mechanism uses compound bridge structure. Theoretical analysis and finite element analysis are carried out to design the hinge structure which has influences on the properties of the moving mechanism. High precision cross roller guide ways are utilized to improve the positioning accuracy of the actuator. The laboratory platform of the piezoelectric inchworm actuator is built. A controlling program of the actuator is compiled by Lab-VIEW. Then, the properties of the actuator are tested. The experimental results show that the working stroke of the actuator is 50 mm, the minimum step pitch is 60 μm the maximum step pitch is 105 μm the fast speed is 2.04 mm/s, the maximum clamping force is 21 N, the maximum dead load is 500 g, and the average speed of the actuator can reach 1.47 mm/s when the driving frequency is 50 Hz and the load is 1 kg.
{"title":"A piezoelectric inchworm actuator based on the principle of flexible amplification","authors":"Li Ma, Chenyang Jiang, Jintao Xiao, Kun Wang, Wei Xie, Bo Liu","doi":"10.1109/3M-NANO.2013.6737414","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737414","url":null,"abstract":"Piezoelectric inchworm actuators have a wide application in the field of Nano positioning and ultra-precision detecting instruments which depend on the characteristics of large stroke, high resolution and rigidity, quick response speed, small size, high driving force, low power consumption, not being affected by electromagnetic interference, and so on. A new piezoelectric inchworm actuator based on the principle of flexible amplification is developed in this paper. In the moving mechanism of the actuator, its clamping mechanism adopts symmetrical lever amplification structure, and its middle drive mechanism uses compound bridge structure. Theoretical analysis and finite element analysis are carried out to design the hinge structure which has influences on the properties of the moving mechanism. High precision cross roller guide ways are utilized to improve the positioning accuracy of the actuator. The laboratory platform of the piezoelectric inchworm actuator is built. A controlling program of the actuator is compiled by Lab-VIEW. Then, the properties of the actuator are tested. The experimental results show that the working stroke of the actuator is 50 mm, the minimum step pitch is 60 μm the maximum step pitch is 105 μm the fast speed is 2.04 mm/s, the maximum clamping force is 21 N, the maximum dead load is 500 g, and the average speed of the actuator can reach 1.47 mm/s when the driving frequency is 50 Hz and the load is 1 kg.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126527456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737456
Jing Li, Feng Du, Jinkai Xu, Xue Wang, Huadong Yu
The multi-coupling characteristics and the contact angle performance of the lower surface of the lotus leaf were investigated through laser scanning confocal microscope, scanning electron microscopy and contact angle measurement. The results indicate that the lower surfaces of the lotus leaf possess biological multi-coupling contents and excellent hydrophobic performance. Scallops morphology, micro grid-like structure and the wax-like materials with the lower surface energy of the lower surfaces of the lotus leaf were systematically investigated as biological coupling contents contributing to improve the hydrophobic performance. In this paper, researchers found that hydrophobic function of the lotus leaf' lower surface are results of interaction among coupling contents by certain coupling mechanisms from the bionic viewpoint.
{"title":"Multi-coupling hydrophobic characteristics on the lower surface of the lotus leaf","authors":"Jing Li, Feng Du, Jinkai Xu, Xue Wang, Huadong Yu","doi":"10.1109/3M-NANO.2013.6737456","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737456","url":null,"abstract":"The multi-coupling characteristics and the contact angle performance of the lower surface of the lotus leaf were investigated through laser scanning confocal microscope, scanning electron microscopy and contact angle measurement. The results indicate that the lower surfaces of the lotus leaf possess biological multi-coupling contents and excellent hydrophobic performance. Scallops morphology, micro grid-like structure and the wax-like materials with the lower surface energy of the lower surfaces of the lotus leaf were systematically investigated as biological coupling contents contributing to improve the hydrophobic performance. In this paper, researchers found that hydrophobic function of the lotus leaf' lower surface are results of interaction among coupling contents by certain coupling mechanisms from the bionic viewpoint.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121308207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737385
L. Zhao, Z. Wang, W. Li, M. Yu, Z. Zhang, J. Xu, Y. Yu, Z. Weng, S. Li, C. Maple, D. Li, Y. Yue
This paper discusses the effect of pulse repetition rates on silicon wafer modification by four-beam laser interference. In the work, four-beam laser interference was used to pattern single crystal silicon wafers for the fabrication of dots, and different laser pulse repetition rates were applied to the process in the air. The results were obtained from 10 laser exposure pulses with the single laser fluence of 283mJ/cm2, the pulse repetition rates were 1Hz, 5Hz and 10Hz, the laser wavelength was 1064nm and the pulse duration 7-9ns. The results have been observed using a scanning electron microscope (SEM) and optical microscope. They indicate that the laser pulse repetition rate has to be properly selected for the fabrication of the structures of dots using four-beam laser interference.
{"title":"Effect of pulse repetition rate on silicon wafer modification by four-beam laser interference","authors":"L. Zhao, Z. Wang, W. Li, M. Yu, Z. Zhang, J. Xu, Y. Yu, Z. Weng, S. Li, C. Maple, D. Li, Y. Yue","doi":"10.1109/3M-NANO.2013.6737385","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737385","url":null,"abstract":"This paper discusses the effect of pulse repetition rates on silicon wafer modification by four-beam laser interference. In the work, four-beam laser interference was used to pattern single crystal silicon wafers for the fabrication of dots, and different laser pulse repetition rates were applied to the process in the air. The results were obtained from 10 laser exposure pulses with the single laser fluence of 283mJ/cm2, the pulse repetition rates were 1Hz, 5Hz and 10Hz, the laser wavelength was 1064nm and the pulse duration 7-9ns. The results have been observed using a scanning electron microscope (SEM) and optical microscope. They indicate that the laser pulse repetition rate has to be properly selected for the fabrication of the structures of dots using four-beam laser interference.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125630609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737454
Huixiang Wang, Lining Sun
Molecular techniques are transforming our understanding of cellular function and disease. However, accurate molecular analysis methods will be limited if the input DNA, RNA, or protein is not derived from pure population of cells or is contaminated by the wrong cells. This paper will introduce a design of a micro-to-nano manipulation device. It was an automatic, rapid, accurate separation and extraction system designated group of cells or single cells for pathology research. Essential micro-to-nano manipulations were executed by microdissection knife based on piezo-power ultrasonic vibration (vibration frequency at 15-50 kHz and amplitude 0.001-1μm) and microcollection tool based on vacuum adsorption (controllable press at 0.001-0.5Mpa). Lots of 5μm liver embedded sections were dissected and collected successfully by many experiments. Contrast testing experiment indicates that no harm to tissue by the ultrasonic dissection tool, good availability to collection by the vacuum adsorption and the micromanipulation system is applicable to bio-micro-to-nano manipulations with high stability and accuracy.
{"title":"Research on a micro-to-nano bio-manipulation device","authors":"Huixiang Wang, Lining Sun","doi":"10.1109/3M-NANO.2013.6737454","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737454","url":null,"abstract":"Molecular techniques are transforming our understanding of cellular function and disease. However, accurate molecular analysis methods will be limited if the input DNA, RNA, or protein is not derived from pure population of cells or is contaminated by the wrong cells. This paper will introduce a design of a micro-to-nano manipulation device. It was an automatic, rapid, accurate separation and extraction system designated group of cells or single cells for pathology research. Essential micro-to-nano manipulations were executed by microdissection knife based on piezo-power ultrasonic vibration (vibration frequency at 15-50 kHz and amplitude 0.001-1μm) and microcollection tool based on vacuum adsorption (controllable press at 0.001-0.5Mpa). Lots of 5μm liver embedded sections were dissected and collected successfully by many experiments. Contrast testing experiment indicates that no harm to tissue by the ultrasonic dissection tool, good availability to collection by the vacuum adsorption and the micromanipulation system is applicable to bio-micro-to-nano manipulations with high stability and accuracy.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132121687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737379
Jin Wei, Jianyi Zheng, G. Zheng, Xiang Wang, Guangqi He, Haiyan Liu, Daoheng Sun, Juan Liu
In this paper, mechanical stretching force is introduced into the Electrohydrodynamic Direct-Write (EDW) process. The effects of mechanical stretching on the rheology and deposition behaviors of EDW jet were investigated. The stretching affects that stemmed from the EDW motion platform provided an extra force on the charged jet. The larger stretching force applied on the jet played a good role to overcome bending instability, and stretch the jet into finer ones. Since the short distance between spinneret and collector, the mechanical stretching force acted more important role on the jet formation process. Thanks to the stretching effect, the whipping of charged jet can be avoided and micro/nano thin film without curve structure can be direct-written on the collector. With increasing collector motion velocity, the line width and thickness of micro/nano thin film will be decreased. During the EDW process, the mechanical stretching force had provided an excellent aspect to control the morphology and deposition pattern of EDWed micro/nano thin film.
{"title":"Pattern stretchable micro-nano thin film via Electrohydrodynamic Direct-Writing","authors":"Jin Wei, Jianyi Zheng, G. Zheng, Xiang Wang, Guangqi He, Haiyan Liu, Daoheng Sun, Juan Liu","doi":"10.1109/3M-NANO.2013.6737379","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737379","url":null,"abstract":"In this paper, mechanical stretching force is introduced into the Electrohydrodynamic Direct-Write (EDW) process. The effects of mechanical stretching on the rheology and deposition behaviors of EDW jet were investigated. The stretching affects that stemmed from the EDW motion platform provided an extra force on the charged jet. The larger stretching force applied on the jet played a good role to overcome bending instability, and stretch the jet into finer ones. Since the short distance between spinneret and collector, the mechanical stretching force acted more important role on the jet formation process. Thanks to the stretching effect, the whipping of charged jet can be avoided and micro/nano thin film without curve structure can be direct-written on the collector. With increasing collector motion velocity, the line width and thickness of micro/nano thin film will be decreased. During the EDW process, the mechanical stretching force had provided an excellent aspect to control the morphology and deposition pattern of EDWed micro/nano thin film.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125647700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737391
Liguo Chen, Xiaowei Xu, Wenyuan He, Lining Sun
According to obtain the mechanism of electrowetting-on-dielectric (EWOD), the instantaneous pressure difference inside a droplet was obtained by means of a numerical simulation method in this paper, which was the root reason for EWOD. First, based upon the theory of electrowetting-on-dielectric(EWOD), a geometrical model of EWOD was established in a commercial software using VOF method. Next, deriving that two kinds of fluid which should follow the law of mass conservation and principle of momentum conservation. The experimental results show that the numerical simulation results are in good agreement with the experimental results, In one period of motion, the higher pressure region inside a droplet will keep changing and transferring along with the driving time until a steady state of pressure difference is obtained; besides, the much longer driving time is, the much larger pressure difference will be inside a droplet. The transfer of higher pressure region is the root reason for droplet establishing the velocity field which vividly illustrates how the droplet deforms.
{"title":"Simulation and experimental verification of driving mechanism for a microfluidic device based on electrowetting-on-dielectric","authors":"Liguo Chen, Xiaowei Xu, Wenyuan He, Lining Sun","doi":"10.1109/3M-NANO.2013.6737391","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737391","url":null,"abstract":"According to obtain the mechanism of electrowetting-on-dielectric (EWOD), the instantaneous pressure difference inside a droplet was obtained by means of a numerical simulation method in this paper, which was the root reason for EWOD. First, based upon the theory of electrowetting-on-dielectric(EWOD), a geometrical model of EWOD was established in a commercial software using VOF method. Next, deriving that two kinds of fluid which should follow the law of mass conservation and principle of momentum conservation. The experimental results show that the numerical simulation results are in good agreement with the experimental results, In one period of motion, the higher pressure region inside a droplet will keep changing and transferring along with the driving time until a steady state of pressure difference is obtained; besides, the much longer driving time is, the much larger pressure difference will be inside a droplet. The transfer of higher pressure region is the root reason for droplet establishing the velocity field which vividly illustrates how the droplet deforms.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125226592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737377
Hui Xie, Munan Yin, Weibin Rang
Cell-surface adhesion forces are significant in regulating cellular activities. In this paper, a nanorobotic system was developed and based on this system, a novel method measuring the cell-surface adhesion force is proposed. The nanorobotic system mainly consists of two independently actuated and sensed microcantilevers, forming a nanotweezer with capabilities of pick-and-place manipulation of a single cell in aqueous environments with accurate force sensing that is sufficiently sensitive to characterize interactions of cell-cell, cell-surface, even single molecules. Capabilities of the developed nanorobotic system have been validated by experimentally qualifying cell-surface adhesion events occurred between C2C12 cells (mouse adherent myoblasts) and Petri dishes under different contact time.
{"title":"Quantification of living cell adhesion forces with a nanorobotic system","authors":"Hui Xie, Munan Yin, Weibin Rang","doi":"10.1109/3M-NANO.2013.6737377","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737377","url":null,"abstract":"Cell-surface adhesion forces are significant in regulating cellular activities. In this paper, a nanorobotic system was developed and based on this system, a novel method measuring the cell-surface adhesion force is proposed. The nanorobotic system mainly consists of two independently actuated and sensed microcantilevers, forming a nanotweezer with capabilities of pick-and-place manipulation of a single cell in aqueous environments with accurate force sensing that is sufficiently sensitive to characterize interactions of cell-cell, cell-surface, even single molecules. Capabilities of the developed nanorobotic system have been validated by experimentally qualifying cell-surface adhesion events occurred between C2C12 cells (mouse adherent myoblasts) and Petri dishes under different contact time.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"66 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134446498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737450
Bowen Zhong, Zhenhua Wang, Tao Chen, Liguo Chen, Lining Sun
In this paper, the relationship of the movement of stick-slip driving and the step time was studied. Firstly, the research status and the principle of stick-slip driving was introduced. Secondly, the math model of the every step displacement and velocity of stick-slip driving was built. By using mathematical models, the relationship curve of the every step displacement and the step time was received through the simulation in Matlab software. Furthermore, in corroboration of the math model, the prototype was designed and the experiment system was built. From the testing of stick-slip prototype, the step displacement in every step time was tested 20 times and the relationship curve of the average every step displacement and step time was obtained. The simulation results are validated by the testing results and the method of reducing the time step to adjust the stick-slip driving step displacement and velocity were proved. In the future, a greater drive power should be researched for improving the movement performance of the stick-slip driving.
{"title":"The study on the effect of step time on the movement of the cross-scale stage based on the stick-slip driving","authors":"Bowen Zhong, Zhenhua Wang, Tao Chen, Liguo Chen, Lining Sun","doi":"10.1109/3M-NANO.2013.6737450","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737450","url":null,"abstract":"In this paper, the relationship of the movement of stick-slip driving and the step time was studied. Firstly, the research status and the principle of stick-slip driving was introduced. Secondly, the math model of the every step displacement and velocity of stick-slip driving was built. By using mathematical models, the relationship curve of the every step displacement and the step time was received through the simulation in Matlab software. Furthermore, in corroboration of the math model, the prototype was designed and the experiment system was built. From the testing of stick-slip prototype, the step displacement in every step time was tested 20 times and the relationship curve of the average every step displacement and step time was obtained. The simulation results are validated by the testing results and the method of reducing the time step to adjust the stick-slip driving step displacement and velocity were proved. In the future, a greater drive power should be researched for improving the movement performance of the stick-slip driving.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121439621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737446
Xiaoli Zhao, W. An, Jiuchun Yan, Liqin Wang
Controlled surface wrinkling could provide ordered and hierarchical structures in micro- and nano-meter scale. Here combined influence of out-of-plane compressive stress and in-plane substrate relief in Au/PDMS bilayer system was experimentally investigated to explore morphological evolution of surface wrinkling. Compared with single influence from out-of-plane compression or in-plane relief, the combined effect mainly reflected in two aspects: edge effect and rearrangement effect. Edge effect applied morphological change on the compressed fields near the edges, but patterns almost restored to the original shape after stress relaxation. Rearrangement effect made relaxed patterns on the rectangular convex regions to rearrange and led to the failure of shape memory effect. The results demonstrated that the combined effect could partly rearrange the original structures, which would be utilized to fabricate the complicated structures.
{"title":"Combined influence of substrate relief and mechanical compression on topographical evolution of surface wrinkling","authors":"Xiaoli Zhao, W. An, Jiuchun Yan, Liqin Wang","doi":"10.1109/3M-NANO.2013.6737446","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737446","url":null,"abstract":"Controlled surface wrinkling could provide ordered and hierarchical structures in micro- and nano-meter scale. Here combined influence of out-of-plane compressive stress and in-plane substrate relief in Au/PDMS bilayer system was experimentally investigated to explore morphological evolution of surface wrinkling. Compared with single influence from out-of-plane compression or in-plane relief, the combined effect mainly reflected in two aspects: edge effect and rearrangement effect. Edge effect applied morphological change on the compressed fields near the edges, but patterns almost restored to the original shape after stress relaxation. Rearrangement effect made relaxed patterns on the rectangular convex regions to rearrange and led to the failure of shape memory effect. The results demonstrated that the combined effect could partly rearrange the original structures, which would be utilized to fabricate the complicated structures.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116848671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-08-01DOI: 10.1109/3M-NANO.2013.6737383
Jinyun Liu, Zuobin Wang, Yingmin Qu, Guoliang Wang, Dayou Li, C. Maple
Paper discusses the effect of fullerenol on the morphology features of colon cancer SW480 cells. In the work, the changes of morphology features of SW480 cells, treated with three groups of fullerenol concentrations, were studied using atomic force microscopy (AFM) to evaluate their induction of apoptosis in colon cancer cells on the nanoscale. There were 20 single cells of each group used to test and determine the changes of their features in the experiments, including untreated SW480 cells, SW480 cells treated with Img/ml fullerenol and SW480 cells treated with 2mg/ml fullerenol. The experimental results have shown that the untreated and treated SW480 cells have different sizes and shapes. The lengths of the cells were decreased and their heights increased with the increase of the fullerenol dose.
{"title":"Effect of fullerenol on the morphology features of SW480 cells","authors":"Jinyun Liu, Zuobin Wang, Yingmin Qu, Guoliang Wang, Dayou Li, C. Maple","doi":"10.1109/3M-NANO.2013.6737383","DOIUrl":"https://doi.org/10.1109/3M-NANO.2013.6737383","url":null,"abstract":"Paper discusses the effect of fullerenol on the morphology features of colon cancer SW480 cells. In the work, the changes of morphology features of SW480 cells, treated with three groups of fullerenol concentrations, were studied using atomic force microscopy (AFM) to evaluate their induction of apoptosis in colon cancer cells on the nanoscale. There were 20 single cells of each group used to test and determine the changes of their features in the experiments, including untreated SW480 cells, SW480 cells treated with Img/ml fullerenol and SW480 cells treated with 2mg/ml fullerenol. The experimental results have shown that the untreated and treated SW480 cells have different sizes and shapes. The lengths of the cells were decreased and their heights increased with the increase of the fullerenol dose.","PeriodicalId":120368,"journal":{"name":"2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale","volume":"223 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123244864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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