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2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale最新文献

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Integration of microfluidic system with silicon nanowires biosensor for multiplexed detection 微流控系统与硅纳米线生物传感器的集成多路检测
A. Gao, P. Dai, N. Lu, Tie Li, Yuelin Wang, S. Hemmila, P. Kallio
This paper propose a novel method of integration microfluidic sample delivery system with silicon nanowire (SiNW) biosensor device, which provide multiplexed detection capability as well as protect the fragile sensing elements from mechanical shocks and surrounding impurities. The SiNWs and PDMS chips were fabricated with complementary metal oxide semiconductor (CMOS) compatibility and low cost methods. They were integrated together by using optimal O2 plasma parameters that enabled rapid and leakage-free bond formation, without additional heating or applied pressure. Capillary action enabled by the hydrophilicity of the channels using polyvinylpyrrolidone (PVP) was also demonstrated to allow analyte solution delivery onto the sensor array directly, exclude the need of using external pumping devices.
本文提出了一种将微流控送样系统与硅纳米线(SiNW)生物传感器器件集成的新方法,该方法既能提供多路检测能力,又能保护脆弱的传感元件免受机械冲击和周围杂质的影响。采用互补金属氧化物半导体(CMOS)兼容和低成本的方法制备了SiNWs和PDMS芯片。它们通过使用最佳的氧等离子体参数集成在一起,无需额外加热或施加压力,即可快速无泄漏地形成键合。通过使用聚乙烯吡罗烷酮(PVP)通道的亲水性,毛细管作用也被证明可以直接将分析物溶液输送到传感器阵列上,而不需要使用外部泵送设备。
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引用次数: 3
Error factors affecting the result of Laser Interference Lithography 影响激光干涉光刻效果的误差因素
Jin Zhang, Shilei Jiang, C. Tan, Zuobin Wang, Dayou Li, Y. Yue, Renxi Qiu, Guobin Sun, Lihong Yang, Sanlong Wang
Laser Interference Lithography (LIL) techniques enable quantitative generation of periodic structures such as array of holes, dots and lines, which are the intrinsic structure in some optical functional material. In this paper, the most common errors factors that could affect the result of laser interference lithography were presented. The methods to enhance the quality of patterns of LIL also have been introduced.
激光干涉光刻(LIL)技术可以定量生成孔阵列、点阵列和线阵列等周期性结构,这些结构是某些光学功能材料的固有结构。本文介绍了影响激光干涉光刻效果的最常见误差因素。本文还介绍了提高LIL图形质量的方法。
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引用次数: 0
Effect of parameters on three-beam laser interference 参数对三束激光干涉的影响
M. Yu, C. Tan, Zuobin Wang, Le Zhao, Wenjun Li
Three-beam laser interference is used to create spot or grating patterns by three laser beams. In this paper, effect of parameters on three-beam laser interference is discussed. Computer simulation results have shown that the parameters and their deviations of incident angles, azimuthal angles and polarization states will affect the period, contrast, shape and direction of the spots of three-beam interference patterns. The patterns can be useful for the structuring of different surface patterns in three-beam laser interference lithography.
三束激光干涉是利用三束激光产生光斑或光栅图样。本文讨论了参数对三束激光干涉的影响。计算机仿真结果表明,入射角、方位角和偏振态的参数及其偏差会影响三束干涉图的光斑周期、对比度、形状和方向。这些图案可用于三束激光干涉光刻中不同表面图案的构造。
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引用次数: 1
Modeling and analysis of factors of size effect in micro-cutting: The tool geometry and the depth of cutting 微切削尺寸效应因素建模与分析:刀具几何形状与切削深度
X. Jing, B. Lin, D. W. Zhang
Based on the finite element approach and the strain gradient (SG) theory, this paper produced a study on factors of size effect and minimum cutting thickness phenomenon in the micro-cutting process. Mechanisms of micro-cutting focusing on its characteristics that include size effect, tool edge radius and minimum cutting thickness has been studied. A new constitutive relationship based on SG theory is formulated to model the size effect of material properties at micro-scale. The new constitutive was implanted into the FEM, and size effect was investigated. From the result of simulation, it is indicated that size effect in micro-cutting could be well formulated by SG theory. The curve of material properties is approached to curve of JC with the depth cutting increased; when the rake angle is increased, the size effect is more obvious. The tool edge radius has a significant influence on the size effect. Result show that the cause of the minimum chip thickness is the tool edge radius.
基于有限元方法和应变梯度理论,对微切削过程中的尺寸效应因素和最小切削厚度现象进行了研究。针对微切削的尺寸效应、刀具边缘半径和最小切削厚度等特征,研究了微切削的机理。基于SG理论,建立了一种新的本构关系,以模拟微观尺度下材料性能的尺寸效应。将新本构引入有限元中,研究了尺寸效应。仿真结果表明,SG理论可以很好地描述微切削中的尺寸效应。随着切削深度的增加,材料性能曲线与JC曲线趋近;当前倾角增大时,尺寸效应更为明显。刀具刃口半径对尺寸效应有显著影响。结果表明,刀具刃口半径是导致切屑厚度最小的主要原因。
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引用次数: 1
Mathematical analysis for controllable near-field electrospinning 可控近场静电纺丝的数学分析
Jie Chen, Zhushuai Shao, Changhai Ru, Zhan Yang
Near-field electrospinning (NFES) is a novel method possessing higher controllability than conventional far-field electrospinning (FFES). But due to the lack of directions of theoretical model, precise deposition of nanofibers could only accomplished by experience. In this work, expressions for jet cross-sectional radius and jet velocity in NFES were derived in terms of axial position and initial jet acceleration. Based on nonlinear curve fitting method in MATLAB, an approximation for initial jet acceleration was acquired. With this model, it was able to accurately predict the diameter and velocity of nanofibers in NFES. Additionally, the movement speed of the workbench can be regulated by mathematical model rather than experience. So the model proposed in this paper had important guiding significance to precise deposition of nanofibers.
近场静电纺丝(NFES)是一种比传统远场静电纺丝(FFES)具有更高可控性的新方法。但由于缺乏理论模型的指导,纳米纤维的精确沉积只能依靠经验来完成。本文推导了NFES中射流截面半径和射流速度的轴向位置和初始射流加速度表达式。基于MATLAB中的非线性曲线拟合方法,得到了初始射流加速度的近似解。利用该模型可以准确地预测纳米纤维在NFES中的直径和速度。此外,工作台的运动速度可以通过数学模型而不是经验来调节。因此本文提出的模型对纳米纤维的精确沉积具有重要的指导意义。
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引用次数: 0
Doping the armchair single-walled carbon nanotubes by silicon substitutions: A density functional theory study 硅取代掺杂扶手型单壁碳纳米管:密度泛函理论研究
Hong-cun Bai, Honghua Ma, Yuhua Wu, Nini Yuan, Jun Li, Yongqiang Ji
In this paper the nanotubes obtained by silicon atoms substitutionally doping the armchair single-walled carbon nanotubes were investigated by quantum chemistry calculations under the framework of density functional theory. The geometrical structures, relative stabilities and electronic properties of the fifteen Si-doped tubes were studied in details and compared with those of the pristine (5, 5) tubes. It is found that the Si atoms tend to “pop out” from the original positions when the silicon atoms are introduced into the nanotubes. The Si-doped nanotubes exhibit lower thermodynamic stability than those of the undoped tubes from viewpoint of cohesive energy, and this is similar to the case of the silicon doped zigzag nanotubes. The energy levels of the frontier orbitals vary very little when the silicon atom is introduced into the nanotubes. However, most hybrid nanotubes present smaller energy gaps than those of the pristine ones.
本文在密度泛函理论的框架下,用量子化学计算方法研究了硅原子取代掺杂扶手型单壁碳纳米管制备的纳米管。详细研究了15个硅掺杂管的几何结构、相对稳定性和电子性能,并与原始(5,5)硅掺杂管进行了比较。当硅原子被引入到纳米管中时,硅原子倾向于从原来的位置“弹出”。从内聚能的角度来看,掺硅纳米管的热力学稳定性低于未掺硅纳米管,这与掺硅之字形纳米管的情况相似。当硅原子被引入纳米管中时,前沿轨道的能级变化很小。然而,大多数混合纳米管呈现出比原始纳米管更小的能隙。
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引用次数: 1
Rotational positioning method based on the microscopic vision 基于显微视觉的旋转定位方法
Yong Wang, Zhan Yang, Junhui Zhu, Yulong Zhu, Changhai Ru, Pengbo Wang
This paper reported a rotational positioning method based on the microscopic vision. Rotational positioning method has important applications in image scanning of biological tissue or cell injection experiments. A compact rotational stage driven by a stepper motor is utilized, and cross mark alignment method with unequal length is proposed to aid positioning. Feature tracking algorithm is utilized to track the target in real time. Combined with the X/Y stage of the inverted microscope and image-based visual servo controller, positioning the biological sample could be completed. The experiment shows that, after positioning the two cross marks' angle deviation is 0.462° and the position difference is 2~3 μm meeting with the biological operation requirements.
本文报道了一种基于显微视觉的旋转定位方法。旋转定位方法在生物组织图像扫描或细胞注射实验中有着重要的应用。采用步进电机驱动的紧凑旋转平台,采用不等长十字标记对中方法辅助定位。利用特征跟踪算法对目标进行实时跟踪。结合倒置显微镜的X/Y台和基于图像的视觉伺服控制器,即可完成生物样品的定位。实验表明,定位后两个十字标记的角度偏差为0.462°,位置差为2~3 μm,满足生物操作要求。
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引用次数: 1
Experimental study of surface roughness effects on wettability 表面粗糙度对润湿性影响的实验研究
Yanling Wan, J. Lou, Jinkai Xu, Xuerui Zhang, Huadong Yu
In this paper, we present a method to fabricate aluminum alloy 5083 surfaces with different surface roughness using reciprocating type high speed wire cut electrical discharge machining (HS-WEDM). Observe the processed surface by ultra-depth three-dimensional scanning system, obviously notice that craters and bumps were uniformly distributed in the surface which is machined by HS-WEDM. And the size of craters and bumps are relevant to the parameters of the pulse power supply. Then we obtain a surface with static contact angle of 136° and draw a changing trends curve of the static contact angle along with surface roughness by measuring the surface roughness and static contact angle respectively. It has provided experimental basis and theoretical foundation for fabricating aluminum alloy super-hydrophobic surface by HS-WEDM.
本文提出了一种利用往复式高速线切割电火花加工(HS-WEDM)加工不同表面粗糙度的铝合金5083表面的方法。利用超深度三维扫描系统对加工表面进行观察,可以明显地看到,在高速电火花线切割加工表面,凹坑和凸点分布均匀。弹坑和凸起的大小与脉冲电源的参数有关。然后,通过测量表面粗糙度和静态接触角,得到静接触角为136°的表面,并绘制出静接触角随表面粗糙度的变化趋势曲线。为利用HS-WEDM加工铝合金超疏水表面提供了实验依据和理论基础。
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引用次数: 9
Elastic translational joint for large translation of motion using spiral structures 采用螺旋结构的大平移运动弹性平移关节
C. Ha, Dong-Yol Yang
As nano/micro devices become smaller, it is important to manipulate them with highly accurate control. The design of micro joint is important for highly accurate movement. This paper discusses a new micro translational joint based on an elastic design concept for precise and large translational motion. By using the elastic deformation of spiral structures, translational joint can manipulate precisely and move long distance. Through finite element method (FEM) simulation, the proposed translational joint was estimated to have a precise and large translational motion. The proposed translational joint is possible to move without friction, and it can be used for micro/nano-sized manipulators. Therefore, it is expected that many applications for highly accurate devices can be manipulated with the proposed translational joint.
随着纳米/微器件的小型化,对其进行高精度控制变得尤为重要。微关节的设计是实现高精度运动的关键。本文讨论了一种基于弹性设计思想的新型微平移关节,用于精确大平移运动。利用螺旋结构的弹性变形,可以实现平移关节的精确操纵和长距离移动。通过有限元仿真,估计该关节具有精确的大平移运动。所提出的平移关节可以在没有摩擦的情况下移动,并且可以用于微/纳米尺寸的机械臂。因此,期望许多高精度设备的应用可以使用所提出的平移关节进行操作。
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引用次数: 11
Rapid detection of neuron specific enolase by chemiluminescence immunoassay using bio-functionlized magnetic nanocomposites 生物功能化磁性纳米复合材料化学发光免疫分析法快速检测神经元特异性烯醇化酶
Jinping Luo, Shuxue Qu, Bin Wang, Juntao Liu, Xinxia Cai
To detect a biomarker for small cell lung carcinoma (SCLC), neuron specific enolase (NSE), a chemiluminescent immunoassay combined with immunomagnetic separation was proposed, in which bio-functionalized magnetic nanocomposites (BFMNs) were used as mobile substrate for capturing and isolating the NSE proteins. The BFMNs coated with anti-NSE antibody would connect with NSE and horseradish peroxidase labeled anti-NSE antibody in a sandwich-type detection manner. After fast magnetic collection, the sandwich immunocomplex is separated from excess antiboby or non-specific proteins. The immunocomplex further reacts with chemiluminescent substrate to produce chemiluminescence. A home-made three-channel luminometer was used to detect the chemiluminescence so as to improve the detection speed. There is a good linear response between the chemiluminescence intensity and the NSE concentration in the range from 2 to 200 ng/mL. The proposed immunoassay also shows good reproducibility and excellent selectivity for NSE against other proteins. The whole detection process including incubation, washing and detection could be performed within 40 min. The proposed method offers a simple, noninvasive and reliable tool for detecting SCLC and has potential application for clinical testing.
为了检测小细胞肺癌(SCLC)的生物标志物神经元特异性烯醇化酶(NSE),提出了一种结合免疫磁分离的化学发光免疫分析方法,该方法使用生物功能化磁性纳米复合材料(BFMNs)作为移动底物捕获和分离NSE蛋白。包被抗NSE抗体的BFMNs以三明治型检测方式与NSE和辣根过氧化物酶标记的抗NSE抗体连接。经过快速磁收集,三明治免疫复合物从多余的抗体或非特异性蛋白质中分离出来。免疫复合物进一步与化学发光底物反应产生化学发光。为了提高检测速度,采用自制的三通道发光计对化学发光进行检测。化学发光强度与NSE浓度在2 ~ 200 ng/mL范围内呈良好的线性关系。所提出的免疫分析也显示出良好的重复性和NSE对其他蛋白质的良好选择性。该方法可在40 min内完成孵育、清洗和检测的整个检测过程,为SCLC的检测提供了一种简单、无创、可靠的工具,具有潜在的临床应用价值。
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引用次数: 1
期刊
2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale
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