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Brain network controllability in genetic risk, childhood abuse, and adult anxiety. 遗传风险、儿童虐待和成人焦虑中的脑网络可控性。
IF 4.1 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-09-12 DOI: 10.1080/20008066.2025.2551953
Tian Tian, Min Chen, Jicheng Fang, Wenzhen Zhu

Background: Network control theory can quantify controllability to evaluate how altered transitions between brain states contribute to cognitive, emotional, and behavioural challenges. Childhood abuse, influenced by genetics, is associated with disrupted network function, though the exact control processes are not yet understood.Objective: This study aims to investigate the association between brain network controllability and childhood abuse experiences, and to elucidate its potential mediating role in the relationship among polygenic risk scores (PRS) for childhood abuse, childhood abuse experiences, and adult health outcomes.Methods: This study measured the controllability of functional brain networks, including both average and modal controllability, in a cohort of 214 young adults with varied histories of childhood abuse. Participants also completed psychological assessments, whole-exome sequencing, and the calculation of PRS for childhood abuse. This study investigate the association between brain network controllability and childhood abuse. Furthermore, a mediation model was performed to explore the potential mediating role of brain network controllability in the relationship between genetic risk, childhood abuse experiences, and adult health outcomes.Results: The controllability of the dorsal attention and sensorimotor networks, as well as the controllability of key ROIs within the sensorimotor, default mode, dorsal attention, visual, and control networks, demonstrated significant correlations with abuse scores. Despite no direct correlation between PRS and self-reported childhood abuse, indirect effects through the controllability of visual and control network regions were identified. The controllability of the left postcentral gyrus in the dorsal attention network mediated the relationship between childhood abuse and adult anxiety.Conclusions: This study reveals that brain network controllability is a pivotal factor, not only bridging PRS and childhood abuse but also serving as a potential mediator between childhood trauma and adult anxiety, offering a new perspective on the neurobiology of childhood abuse-related psychopathology.

背景:网络控制理论可以量化可控性,以评估大脑状态之间的转变如何导致认知、情绪和行为挑战。受基因影响的童年虐待与网络功能紊乱有关,尽管确切的控制过程尚不清楚。目的:探讨脑网络可控性与儿童虐待经历的关系,并探讨其在儿童虐待多基因风险评分(PRS)、儿童虐待经历和成人健康结局之间的中介作用。方法:本研究测量了214名有不同童年虐待史的年轻人的脑功能网络的可控性,包括平均可控性和模态可控性。参与者还完成了心理评估、全外显子组测序和儿童期虐待的PRS计算。本研究探讨脑网络可控性与儿童虐待的关系。此外,我们还建立了一个中介模型来探讨脑网络可控性在遗传风险、童年虐待经历和成人健康结果之间的关系中的潜在中介作用。结果:背侧注意网络和感觉运动网络的可控性,以及感觉运动网络、默认模式网络、背侧注意网络、视觉网络和控制网络中关键roi的可控性与虐待得分呈显著相关。尽管PRS与自我报告的童年虐待之间没有直接关联,但通过视觉和控制网络区域的可控性发现了间接影响。儿童虐待与成人焦虑之间的关系,在背侧注意网络左侧中央后回的可控制性中起中介作用。结论:本研究揭示了脑网络可控性是连接PRS与儿童虐待的关键因素,也是儿童创伤与成人焦虑之间的潜在中介,为儿童虐待相关精神病理的神经生物学研究提供了新的视角。
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引用次数: 0
Towards a better definition of nociplastic pain conditions: a psychological grounded study on fibromyalgia, chronic headache and vulvodynia. 对致害性疼痛的更好定义:纤维肌痛、慢性头痛和外阴痛的心理学基础研究。
IF 4.2 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-02-13 DOI: 10.1080/20008066.2025.2461434
Martina Mesce, Filippo Maria Nimbi, Piercarlo Sarzi-Puttini, Carlo Lai, Federica Galli

Background: This study investigates the psychological underpinnings of chronic pain conditions, specifically fibromyalgia, chronic headache, vulvodynia, and mixed condition (consisting of fibromyalgia in comorbidity with chronic headache and/or vulvodynia), with a focus on nociplastic pain mechanisms.Objective: The aim of the study is to better understand the psychological functioning of women with different chronic pain conditions to identify and discuss similarities and differences. In particular, we aim to explore any significant differences in the domain of traumatic experiences, in global defensive functioning, and in the domain of alexithymia among the evaluated groups. Further, the 4 groups with chronic pain will be compared with a healthy control group.Methods: A sample of 1006 Italian women diagnosed with chronic pain participated in the study, categorized into four clinical groups and a healthy control group. Measures were assessed using self-report measures, in particular: Traumatic Experiences Checklist, Defense Mechanism Rating Scales, and Toronto Alexithymia Scale.Results: There are significant differences among groups, with mixed conditions exhibiting the highest levels of traumatic experiences, particularly emotional neglect and physical threats. Fibromyalgia and mixed condition groups displayed greater reliance on neurotic defense mechanisms. Additionally, fibromyalgia and mixed condition participants exhibited higher levels of alexithymia, indicating difficulties in emotional processing.Conclusions: These findings underscore the complex interplay between psychological factors and nociplastic pain conditions, emphasizing the importance of personalized psychological interventions in managing nociplastic pain. The study highlights the need for multidisciplinary approaches to nociplastic pain treatment, considering the diverse psychological profiles of affected individuals.

背景:本研究探讨了慢性疼痛的心理基础,特别是纤维肌痛、慢性头痛、外阴痛和混合情况(包括纤维肌痛并伴有慢性头痛和/或外阴痛),重点探讨了致伤性疼痛的机制。目的:本研究旨在更好地了解不同慢性疼痛症状女性的心理功能,识别并探讨其异同。特别是,我们的目标是探索创伤经历领域的任何显著差异,在整体防御功能,并在述情障碍领域的评估组。并将4组慢性疼痛患者与健康对照组进行比较。方法:1006名诊断为慢性疼痛的意大利女性参与研究,分为四个临床组和一个健康对照组。评估方法采用自我报告方法,特别是:创伤经历检查表、防御机制评定量表和多伦多述情障碍量表。结果:各组之间存在显著差异,混合条件表现出最高水平的创伤经历,特别是情感忽视和身体威胁。纤维肌痛和混合症状组更依赖神经防御机制。此外,纤维肌痛和混合状态的参与者表现出更高水平的述情障碍,表明情绪处理困难。结论:这些发现强调了心理因素与伤害性疼痛状况之间复杂的相互作用,强调了个性化心理干预在治疗伤害性疼痛中的重要性。该研究强调,考虑到受影响个体的不同心理特征,需要多学科方法来治疗伤害性疼痛。
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引用次数: 0
Engaging Ukrainian TF-CBT therapists in a PRACTICE skills course to support their wellbeing. 让乌克兰TF-CBT治疗师参与实践技能课程,以支持他们的健康。
IF 4.2 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-03-26 DOI: 10.1080/20008066.2025.2476898
Elisabeth Pollio, Esther Deblinger, Beth Cooper, Maike Garbade, Julie P Harrison, Elisa Pfeiffer

Background: Burnout and secondary traumatic stress (STS) are common among therapists working with trauma-exposed clients, which can negatively impact them professionally and personally. The shared trauma of war exposure may put therapists at greater risk. To help support their wellbeing, an eight-session course was offered to Ukrainian therapists following training in Trauma-Focused Cognitive Behavioral Therapy (TF-CBT). This course involves therapists personally utilizing the PRACTICE skills taught to clients in TF-CBT for professional and personal benefit.Objective: The objective was to gather preliminary evidence on the potential impact of implementing the course with Ukrainian therapists providing TF-CBT during a period of war in Ukraine. Specifically, this study examined if course participation was associated with increased PRACTICE coping skills usage, decreased burnout and STS, increased feelings of TF-CBT competency/confidence, and increased empathy for clients' experiences when implementing the skills.Method: The eight-session virtual course included cultural adaptations to increase its compatibility with Ukrainian culture. Thirteen matched pre-post course surveys were analysed to provide preliminary data on the course's effect on PRACTICE coping skills usage, burnout, and STS. The course's impact on therapist coping/wellbeing, TF-CBT competency/confidence, and empathy for clients was also examined qualitatively.Results: PRACTICE coping skills were utilized significantly more frequently at post-course compared to pre-course (p = .010). Therapists also reported lower average scores for burnout and STS after course completion, though these changes were not statistically significant. Most participants (92.3%) reported professional benefits from course participation including increased competency/confidence and empathy for clients. All therapists (100%) reported personal benefits from course participation including increased use of coping skills.Conclusions: Results indicate that participants experienced professional and personal benefits from course completion. This study provides helpful preliminary evidence of a positive impact, however, given the small sample size, larger scale implementation is needed.

背景:职业倦怠和继发性创伤应激(STS)在治疗创伤暴露客户的治疗师中很常见,这会对他们的专业和个人产生负面影响。暴露在战争中的共同创伤可能会使治疗师面临更大的风险。为了帮助支持他们的健康,乌克兰治疗师在接受创伤认知行为疗法(TF-CBT)培训后,接受了一项为期8期的课程。本课程包括治疗师亲自使用TF-CBT中教授给客户的实践技能,以获得专业和个人利益。目的:目的是收集初步证据,证明在乌克兰战争期间,乌克兰治疗师提供TF-CBT课程实施的潜在影响。具体而言,本研究考察了课程参与是否与增加PRACTICE应对技能的使用、减少倦怠和STS、增加对TF-CBT能力/信心的感觉以及在实施技能时对客户体验的同理心有关。方法:八节虚拟课程包括文化适应,以增加其与乌克兰文化的兼容性。我们分析了13个匹配的课程前后调查,以提供课程对PRACTICE应对技能使用、倦怠和STS的影响的初步数据。该课程对治疗师应对/幸福感、TF-CBT能力/信心以及对来访者的同理心的影响也进行了定性研究。结果:实践应对技能在课程后的使用频率明显高于课程前(p = 0.010)。治疗师还报告说,课程结束后,倦怠和STS的平均得分较低,尽管这些变化没有统计学意义。大多数参与者(92.3%)报告了参与课程的专业好处,包括提高了能力/信心和对客户的同情。所有治疗师(100%)都报告了参与课程的个人益处,包括增加了应对技能的使用。结论:研究结果表明,学员在完成课程后获得了专业和个人的好处。这项研究为积极影响提供了有益的初步证据,然而,由于样本量小,需要更大规模的实施。
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引用次数: 0
A meta-analysis on gender differences in prevalence estimates of mental disorders following exposure to natural hazards. 自然灾害暴露后精神障碍患病率估计的性别差异荟萃分析。
IF 4.1 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-03-26 DOI: 10.1080/20008066.2025.2476809
Isabella Kai Lee Nolting, Nexhmedin Morina, Thole Hilko Hoppen, Kim-Pong Tam, Ahlke Kip

Background: Women report higher rates of trauma-related disorders compared to men. With women being disproportionately impacted by the consequences of natural hazards, this gender disparity may increase in their aftermath.Objective: This meta-analysis aimed at quantifying gender gaps in mental disorder prevalence following natural hazards, considering both the recent and long-term aftermath of natural hazards, the developmental status of affected countries, and type of hazard.Method: A systematic search was conducted in MEDLINE, PsycINFO, and Web of Science in February 2024. Random effects models were used to calculate odds ratios (OR) based on point prevalences. OR adjusted for covariates were also descriptively reported.Results: In total, 141 reports (N = 3,726,153 independent participants) were included. The prevalence for posttraumatic stress disorder (PTSD), major depression (MD), and generalized anxiety disorder (GAD) within the first year after the hazard were 24.95%, 8.11%, and 14.24%, respectively. More than one-year post-natural hazard the prevalence for PTSD and MD were 22.89% and 13.51%, respectively. Women had significantly higher odds for PTSD (OR = 1.85) and MD (OR = 1.52) within the first year after the hazard, as well as in later assessments (OR = 1.83 for PTSD, OR = 1.41 for MD). Only four studies reported on GAD gender differences in the recent aftermath of natural hazards, resulting in a non-significant OR of 1.85. Subgroup analyses indicated no differences between developmental status of affected countries and adjusted OR showed no systematic variations upon the inclusion of covariates. Gender differences were larger in the aftermath of earthquakes.Conclusions: Significant gender differences for mental disorders following natural hazards exist, although these differences appear similar to other contexts. Gender-sensitive disaster response plans for mental health are essential.

背景:与男性相比,女性患创伤相关疾病的比例更高。由于妇女受到自然灾害后果的影响不成比例,这种性别差异可能会在灾害发生后进一步扩大。目的:本荟萃分析旨在量化自然灾害后精神障碍患病率的性别差异,同时考虑自然灾害的近期和长期后果、受灾国家的发展状况和灾害类型。方法:系统检索2024年2月的MEDLINE、PsycINFO、Web of Science。随机效应模型用于计算基于点患病率的优势比(OR)。对协变量进行OR校正后也进行了描述性报道。结果:共纳入141份报告(N = 3,726,153名独立参与者)。创伤后应激障碍(PTSD)、重度抑郁症(MD)和广泛性焦虑症(GAD)在发病后一年内的患病率分别为24.95%、8.11%和14.24%。自然灾害后1年以上PTSD和MD患病率分别为22.89%和13.51%。在危险发生后的第一年,女性患PTSD (OR = 1.85)和MD (OR = 1.52)的几率明显更高,在随后的评估中(PTSD OR = 1.83, MD OR = 1.41)。只有四项研究报告了在自然灾害的近期后果中广泛性焦虑症的性别差异,导致了1.85的非显著OR。亚组分析表明,受影响国家的发展状况之间没有差异,调整后的OR在纳入协变量时没有显示出系统差异。在地震后,性别差异更大。结论:自然灾害后的精神障碍存在显著的性别差异,尽管这些差异在其他情况下相似。对性别问题有敏感认识的心理健康灾害应对计划至关重要。
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引用次数: 0
Traumatic stress in times of war: a shared responsibility for health professionals. 战争时期的创伤压力:卫生专业人员的共同责任。
IF 4.1 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-10-07 DOI: 10.1080/20008066.2025.2565117
Hala Kerbage, Eva Alisic, Marit Sijbrandij, Iryna Frankova, Diane Purper-Ouakil, Eric Bui

Background: Armed conflicts continue to inflict profound human suffering, dismantling health systems, displacing populations, and leaving lasting psychological scars. Although war is rooted in political and geopolitical dynamics, its consequences manifest daily in the clinical and ethical dilemmas faced by health professionals.Objective: This editorial calls for a greater ethical and professional commitment from mental health professionals - particularly those in safer contexts - to address the psychological, systemic, and societal impacts of war.Method: Drawing from current evidence in traumatic stress, humanitarian law, and global health, we examine the multilayered consequences of armed conflict, including PTSD, depression, grief, and intergenerational trauma. We reflect on the responsibilities of trauma specialists in times of political violence and mass displacement.Results: The psychological toll of war is amplified by the collapse of support systems, obstruction of care, and direct targeting of healthcare workers. Mental health professionals possess unique expertise not only in treatment, but also in advocacy, education, and testimony. However, trauma care often remains confined to clinical settings, disconnected from policy and public discourse. This editorial emphasises that silence - particularly from those in positions of relative safety - is not neutral, but complicit.Conclusions: There is a professional and ethical imperative for trauma specialists to move beyond the treatment room. This includes amplifying the voices of affected communities, informing policy with trauma-informed evidence, and confronting the systemic injustices that perpetuate violence. Upholding the core values of care, dignity, and justice requires a broader, more engaged response: not only to the aftermath of trauma, but to the structures that produce and sustain it.

背景:武装冲突继续给人类造成深重苦难,摧毁卫生系统,使人口流离失所,并留下持久的心理创伤。虽然战争的根源在于政治和地缘政治动态,但其后果每天都表现在卫生专业人员面临的临床和道德困境中。目的:本社论呼吁精神卫生专业人员,特别是在安全环境中的精神卫生专业人员,作出更大的道德和专业承诺,以应对战争的心理、系统和社会影响。方法:根据目前在创伤应激、人道主义法和全球健康方面的证据,我们研究了武装冲突的多层次后果,包括创伤后应激障碍、抑郁、悲伤和代际创伤。我们反思在政治暴力和大规模流离失所时期创伤专家的责任。结果:战争的心理代价被支持系统的崩溃,护理的阻碍和直接针对医护人员放大。精神卫生专业人员不仅在治疗方面,而且在宣传、教育和证词方面都具有独特的专业知识。然而,创伤护理往往仍然局限于临床环境,与政策和公众话语脱节。这篇社论强调,沉默——尤其是那些处于相对安全位置的人——不是中立的,而是同谋的。结论:创伤专家走出治疗室是一种专业和道德的要求。这包括放大受影响社区的声音,以创伤证据为政策提供信息,以及面对使暴力永久化的系统性不公正。维护关怀、尊严和正义的核心价值需要更广泛、更积极的应对:不仅要应对创伤的后果,还要应对产生和维持创伤的结构。
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引用次数: 0
Self-compassion, self-coldness, and social support and their relationship with depression, anxiety, and PTSD symptoms following a massive terror attack: a prospective study. 自我同情、自我冷漠和社会支持及其与大规模恐怖袭击后抑郁、焦虑和创伤后应激障碍症状的关系:一项前瞻性研究
IF 4.2 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-02-17 DOI: 10.1080/20008066.2025.2461948
Efrat Barel, Lubna Tannous-Haddad, Orna Tzischinsky

Background: On 7 October 2023, Israel suffered a massive deadly terror attack with 1400 civilians murdered and 240 kidnapped. Recent studies have documented an increase in depression, anxiety, and posttraumatic symptoms in the aftermath of the attack. In the area of trauma, it has been shown that while some individuals are vulnerable to developing psychopathology following exposure to a traumatic event, the majority are not.Objective: In the present prospective study, we examined the contributions of internal (self-compassion and self-coldness) and external (social support) resources to depression, anxiety, and posttraumatic symptoms among civilians following a massive terror attack.Method: A total of 250 participants - 126 females (50.4%) and 124 males (49.6%); 156 Jews (62.4%) and 94 Arabs (37.6%) - aged 21-60 (M  = 41.7, SD = 10.63) completed questionnaires at two time points: T1 was in September 2023 (3-4 weeks before the attack) and T2 was in February-March 2024 (19-20 weeks after the attack). Participants were assessed using the Multidimensional Scale of Perceived Social Support (MSPSS), Self-Compassion Scale - Short Form (SCS-SF), Depression, Anxiety, and Stress Scale-21 Items (DASS-21), and International Trauma Questionnaire (ITQ).Results: Self-compassion and social support were negatively associated with depression and anxiety, while self-coldness was positively associated with depression and anxiety. In addition, self-coldness uniquely contributed to the prediction of psychopathological outcomes, including the sense of threat symptoms cluster of posttraumatic stress disorder, beyond known risk factors.Conclusions: Our study highlights the role of self-coldness as a vulnerability factor for civilians following a terror attack. It is important to view the distinct facets of self-compassion as a therapeutic target when building both intervention and prevention programs for people exposed directly and indirectly to trauma.

背景:2023年10月7日,以色列遭受大规模恐怖袭击,1400名平民被杀害,240人被绑架。最近的研究表明,在袭击发生后,抑郁、焦虑和创伤后症状有所增加。在创伤领域,有研究表明,虽然有些人在经历创伤事件后容易出现精神病理,但大多数人都不会。目的:在本前瞻性研究中,我们探讨了内部资源(自我同情和自我冷淡)和外部资源(社会支持)对大规模恐怖袭击后平民抑郁、焦虑和创伤后症状的贡献。方法:共250例受试者,其中女性126例(50.4%),男性124例(49.6%);156名犹太人(62.4%)和94名阿拉伯人(37.6%),年龄21-60岁(M = 41.7, SD = 10.63),分别在2023年9月(袭击前3-4周)和2024年2 - 3月(袭击后19-20周)两个时间点完成问卷调查。采用多维感知社会支持量表(MSPSS)、自我同情简易量表(SCS-SF)、抑郁、焦虑和压力量表-21 (DASS-21)和国际创伤问卷(ITQ)对参与者进行评估。结果:自我同情和社会支持与抑郁、焦虑呈负相关,自我冷漠与抑郁、焦虑呈正相关。此外,自我冷淡对心理病理结果的预测有独特的贡献,包括创伤后应激障碍的威胁感症状群,超出了已知的风险因素。结论:我们的研究突出了自我冷淡作为平民在恐怖袭击后的脆弱性因素的作用。在为直接或间接遭受创伤的人建立干预和预防项目时,将自我同情的不同方面视为治疗目标是很重要的。
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引用次数: 0
'We're all in this together': the protective role of belongingness in the contribution of moral injury to mental health among participants in Israel's civil protest movement. 我们同舟共济":归属感在以色列公民抗议运动参与者的精神伤害对心理健康的影响中的保护作用。
IF 4.2 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-03-10 DOI: 10.1080/20008066.2025.2474374
Yossi Levi-Belz, Yoav Groweiss, Iris Shachar Lavie, Yael Shoval Zuckerman, Carmel Blank

Background: Participating in long-term protests against government actions can affect protesters' mental health and expose protesters to potentially morally injurious events (PMIEs), such as the betrayal by leaders they once trusted. This study aimed to shed light on the potential psychological buffers against the deleterious effects of exposure to PMIEs of betrayal among protesters and to examine the moderating role of belongingness in the relationships between protesters' exposure to PMIEs and stress, PTSD and depression levels.Method: The study sample comprised 4036 Israeli protesters (Mage = 54.27, SD = 12.45; 75.6% females) who took part in the unfolding civil protest movement against the government-led judicial and constitutional overhaul between January 2023 and August 2023. Protesters completed validated self-report questionnaires that included measures of PMIEs, stress, depressive and PTSD symptoms (PTSS).Results: Beyond demographic and protest-related characteristics, exposure to PMIEs of betrayal was found to contribute to both PTSD and depression levels. The indirect effects of PMIE-betrayal on PTSS/depressive symptoms through stress levels were significant, particularly when belongingness levels were low. Thus, a greater sense of PMIE-betrayal contributes to stress symptoms, which, in turn, is linked to higher levels of PTSS and depressive symptoms for protesters having low levels of belongingness.Conclusions: The study's findings highlight the critical contribution of PMIE-betrayal to both PTSS and depression levels, which were mediated by levels of stress. Moreover, experiencing belongingness moderated these relationships. Clinicians treating protesters coping with PTSS and depressive symptoms should also adopt therapeutic aims of establishing belongingness and social support among the protesters.

背景:参加反对政府行为的长期抗议活动会影响抗议者的心理健康,并使抗议者面临潜在的道德伤害事件(PMIEs),例如他们曾经信任的领导人的背叛。本研究旨在揭示潜在的心理缓冲因素,以防止抗议者暴露于背叛事件的有害影响,并研究归属感在抗议者暴露于背叛事件与压力、创伤后应激障碍和抑郁水平之间关系中的调节作用:研究样本包括 4036 名以色列抗议者(Mage = 54.27,SD = 12.45;75.6% 为女性),他们在 2023 年 1 月至 2023 年 8 月期间参加了正在展开的反对政府主导的司法和宪法改革的民间抗议运动。抗议者填写了经过验证的自我报告问卷,其中包括PMIEs、压力、抑郁和创伤后应激障碍症状(PTSS)的测量:结果:除了与人口统计学和抗议相关的特征外,研究还发现暴露于背叛的PMIEs会导致创伤后应激障碍和抑郁水平。PMIE-背叛通过压力水平对创伤后应激障碍/抑郁症状的间接影响是显著的,尤其是当归属感水平较低时。因此,对于归属感水平较低的抗议者来说,较强的PMIE-背叛感会导致压力症状,而压力症状又与较高的创伤后应激障碍和抑郁症状有关:本研究的结论强调了PMIE-背叛对PTSS和抑郁水平的重要影响,而压力水平又是PTSS和抑郁水平的中介。此外,归属感也会调节这些关系。临床医生在治疗应对 PTSS 和抑郁症状的抗议者时,也应采取在抗议者中建立归属感和社会支持的治疗目标。
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引用次数: 0
Enduring intensity for healing: the patient perspective of intensive outpatient treatment for PTSD. 持久的愈合强度:创伤后应激障碍门诊强化治疗的患者视角。
IF 4.2 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-05-06 DOI: 10.1080/20008066.2025.2497160
Maria Bragesjö, Volen Z Ivanov, Sara Farman, Margareta Panagiotidou, Rakel Eklund, Christian Rück

Background: Prolonged exposure is widely regarded as a first-line treatment for alleviating symptoms of post-traumatic stress disorder (PTSD); however, it is often associated with high dropout rates and may not always be sufficiently efficacious. Intensified treatment has been suggested as a solution to increase treatment efficacy and reduce dropout rates, but little is known about patients' preferences for this type of treatment.

Objective: To investigate patients' experiences of prolonged exposure delivered in an intensive format (iPE).

Method: Semi-structured interviews were conducted with 12 participants after completion of iPE.

Results: Thematic analysis of the data yielded one overarching theme 'Brutal Yet Worth It,' accompanied by five subthemes: Building Blocks of Commitment, Strength through collective support, Overcoming challenges of the intensive treatment week, Therapeutic gains of the intensive treatment, and Facilitating and Enabling Treatment Progress. The participants described short-term discomfort and demands, contrasted with the recognition of substantial benefits that extended beyond PTSD symptom reduction. The interplay of individual attributes and experience of social support emerged as crucial factors shaping the experience.

Conclusions: Participants described the iPE experience as intense and demanding, yet transformative and worthwhile in the interviews. These findings highlight the complex and multifaceted experiences of patients undergoing PE delivered in an intensive format. The findings could offer valuable insights for designing more well-received PTSD treatments, leading to enhancements in the overall quality of intensified treatment approaches.

背景:长期暴露被广泛认为是缓解创伤后应激障碍(PTSD)症状的一线治疗方法;然而,它往往与高辍学率有关,可能并不总是足够有效。强化治疗已被认为是提高治疗效果和降低辍学率的一种解决方案,但对患者对这种治疗的偏好知之甚少。目的:探讨患者长期暴露于强化形式(iPE)的经历。方法:在完成iPE课程后,对12名参与者进行半结构化访谈。结果:数据的专题分析产生了一个总体主题“残酷但值得”,并附有五个副主题:承诺的构建模块,通过集体支持的力量,克服强化治疗周的挑战,强化治疗的治疗收益,以及促进和支持治疗进展。参与者描述了短期的不适和需求,与之形成对比的是,他们认识到实质性的好处超出了PTSD症状的减轻。个人属性和社会支持经验的相互作用成为塑造经验的关键因素。结论:参与者在访谈中将iPE的经历描述为紧张和苛刻,但具有变革性和价值。这些发现强调了以密集形式接受PE的患者的复杂和多方面的经历。这些发现可以为设计更受欢迎的创伤后应激障碍治疗提供有价值的见解,从而提高强化治疗方法的整体质量。
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引用次数: 0
Veterans regaining control; preliminary effects of inpatient Dialectical Behavior Therapy based PTSD treatment. 退伍军人重获控制权;住院患者辩证行为疗法治疗PTSD的初步效果。
IF 4.1 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-10-27 DOI: 10.1080/20008066.2025.2568266
Gerda Wesseling, Evelyn Nispeling, Juernene Tholel, Shanna Teunissen, Kathleen Thomaes

Introduction: Trauma-focused therapy (TFT) is highly effective in posttraumatic stress disorder (PTSD). However, there is some evidence that TFT is less effective in specific groups, such as veterans and people with comorbid personality disorders, emotion regulation problems or substance use disorders.Aim: In this pre-post pilot study, we investigated feasibility and effectiveness of a 12-week veteran intensive treatment consisting of integrated Dialectical Behavior Therapy (DBT) and TFT, in Dutch veterans with PTSD, comorbid emotion regulation and/or substance use problems.Results: Self-reported PTSD symptoms (PCL-5) showed a statistically significant decrease from pre- to posttreatment, with a large effect size (Cohen's d = 2.92), as well as general psychiatric symptoms (OQ-45, Cohen's d = 1.85). Self-efficacy (Dutch SES) significantly increased with a medium effect size (Cohen's d = 0.80). Reduction of total score of borderline personality symptoms (PAI-BOR) did not reach statistical significance, although its subscale affective instability showed a statistically significant medium decrease (Cohen's d = 0.59). Feasibility of implementation of the treatment programme was sufficiently good, with a response rate on posttreatment measurements of 66% and 50% at 6 and 10 weeks respectively. Patients who did not completed the posttreatment measurements did not significantly differ on primary and secondary outcome measures from completers.Conclusion: Feasibility and preliminary results from the 12-week DBT-based veteran intensive treatment programme are positive. This provides hope and opportunity for this patient group with a generally less positive response to regular evidence-based PTSD treatments.

创伤聚焦疗法(TFT)对创伤后应激障碍(PTSD)非常有效。然而,有一些证据表明,TFT在特定群体中效果较差,例如退伍军人和患有共病人格障碍、情绪调节问题或物质使用障碍的人。目的:本研究旨在探讨由辩证行为疗法(DBT)和TFT相结合的12周老兵强化治疗对荷兰退伍军人创伤后应激障碍(PTSD)、共病情绪调节和/或物质使用问题的可行性和有效性。结果:自我报告的PTSD症状(PCL-5)与治疗前相比有统计学显著下降,且效应量大(Cohen’s d = 2.92),一般精神症状(OQ-45, Cohen’s d = 1.85)。自我效能感(荷兰SES)显著增加,具有中等效应量(Cohen’s d = 0.80)。边缘型人格症状(PAI-BOR)总分的降低未达到统计学意义,但其分量表情感不稳定性有统计学意义的中度降低(Cohen’s d = 0.59)。实施治疗方案的可行性非常好,治疗后测量的有效率在第6周和第10周分别为66%和50%。未完成治疗后测量的患者与完成治疗后测量的患者在主要和次要结果测量上没有显著差异。结论:12周基于dbt的退伍军人强化治疗方案的可行性和初步结果是肯定的。这为这群通常对常规循证PTSD治疗反应不太积极的患者提供了希望和机会。
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引用次数: 0
Experiences and impact of moral injury in prisons. 监狱道德伤害的经验与影响。
IF 4.1 2区 医学 Q1 PSYCHIATRY Pub Date : 2025-12-01 Epub Date: 2025-01-13 DOI: 10.1080/20008066.2024.2445899
Victoria Williamson, Dominic Murphy, Danielle Lamb, Radha Kothari, Derek Tracy, Neil Greenberg

Moral injury is the persistent mental or emotional distress resulting from events that challenge one's moral beliefs. It is characterised by intense shame, guilt, worthlessness, disgust or anger and can contribute towards the development of serious mental disorders. The nature of working in prisons means that staff often face physically and psychologically challenging scenarios, and prison staff report high rates of mental ill-health and suicidal thoughts. Equally, detainees may be especially vulnerable to moral injury-related mental health difficulties having engaged in illicit actions and been found guilty by a jury of their peers as well as, in high profile cases, the court of public opinion. Despite this, there is an evidence gap about the extent of moral injury in both prison staff and detainee populations, and about how prison staff/detainees can be better supported. How struggling with moral injury may be linked to reoffending amongst detainees and burnout or resignations in prisons staff is currently unknown. In resource strapped prison settings, emerging treatments for moral injury-related mental health difficulties are unlikely to be appropriate or feasible. In this article, we highlight the contexts in which moral injury may arise; the unique challenges to treatment and support for moral injury in prison settings; and offer targeted recommendations for future research and clinical practice.

道德伤害是由于挑战一个人的道德信仰的事件而造成的持续的精神或情感上的痛苦。它的特征是强烈的羞耻、内疚、毫无价值、厌恶或愤怒,并可能导致严重精神障碍的发展。监狱工作的性质意味着工作人员经常面临身体和心理上的挑战,监狱工作人员报告精神疾病和自杀念头的比例很高。同样,被拘留者可能特别容易受到与精神健康问题有关的精神伤害,因为他们从事了非法行为,并被同侪组成的陪审团判定有罪,在备受关注的案件中,也被舆论法庭判定有罪。尽管如此,关于监狱工作人员和被拘留者的道德伤害程度,以及如何更好地支持监狱工作人员/被拘留者,都存在证据差距。与道德伤害作斗争与被拘留者的重新犯罪以及监狱工作人员的倦怠或辞职之间的关系目前尚不清楚。在资源紧张的监狱环境中,针对与道德伤害有关的精神健康困难的新疗法不太可能是适当的或可行的。在这篇文章中,我们强调了道德伤害可能出现的背景;监狱环境中精神创伤治疗和支持的独特挑战;并为未来的研究和临床实践提供有针对性的建议。
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引用次数: 0
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European Journal of Psychotraumatology
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