Francesca Incardona, Federica Bellerba, Sara Gandini, Alessandro Cozzi-Lepri
Armed conflicts often expose groups protected under international humanitarian law, such as healthcare workers (HW) and journalists (JN), to disproportionate risks and in the Israel Gaza war it was particularly evident. However, quantitative assessments of their mortality relative to the general population remain limited. Using official data sources, cross-referenced lists from professional associations, and rigorous statistical methods, we estimated higher mortality among HW and JN during the 2023-24 Israel Gaza war. Mortality risks were consistently higher among these protected groups, ranging from 36% to more than sixfold higher for journalists compared with Gaza residents of the same age and sex. Our findings highlight the urgent global need to protect HW and JN in all conflict settings and to ensure accountability for violations of international humanitarian law.
{"title":"Mortality risk for healthcare workers and journalists in the Gaza Strip over 2023-24.","authors":"Francesca Incardona, Federica Bellerba, Sara Gandini, Alessandro Cozzi-Lepri","doi":"10.1093/eurpub/ckaf241","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf241","url":null,"abstract":"<p><p>Armed conflicts often expose groups protected under international humanitarian law, such as healthcare workers (HW) and journalists (JN), to disproportionate risks and in the Israel Gaza war it was particularly evident. However, quantitative assessments of their mortality relative to the general population remain limited. Using official data sources, cross-referenced lists from professional associations, and rigorous statistical methods, we estimated higher mortality among HW and JN during the 2023-24 Israel Gaza war. Mortality risks were consistently higher among these protected groups, ranging from 36% to more than sixfold higher for journalists compared with Gaza residents of the same age and sex. Our findings highlight the urgent global need to protect HW and JN in all conflict settings and to ensure accountability for violations of international humanitarian law.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marianna Zarro, Alessia Ferranti, Giulia Garagozzo, Giuseppe Fico, Leandro Pecchia
Regulatory frameworks that integrate environmental sustainability into the lifecycle of medical devices (MDs) are essential to ensure quality, safety, and effectiveness for patients while minimizing environmental impact. The Medical Device Regulation 2017/745/EC (MDR) establishes the core framework for MDs, but additional EU legislation addresses Ecodesign, sustainable packaging, financial incentives, and waste management. Although sustainability is not explicitly included in the MDR, understanding how complementary EU regulations contribute to the European Green Deal agenda is crucial to inform decisionmakers and guide future integration of sustainability principles into medical device governance. We employed a validated policy mapping methodology, derived from the scoping review approach and adapted to systematically identify and analyse regulatory documents from policy repositories rather than academic databases. This method has been previously applied in diverse policy domains, including health, education, and digital innovation. Findings were reported according to the PRISMA-ScR. Eight binding regulations that are either directly applicable or transferable to MDs in the European Union were identified. Together, they introduce requirements on Ecodesign, packaging, financial incentives, and waste management. These complement the MDR framework by embedding sustainability principles into various stages of the MD lifecycle, even though they are not explicitly mandated within the MDR itself. While environmental sustainability provisions remain absent from the MDR, complementary EU regulations create an emerging framework that supports systemic economic transformation in line with the European Green Deal. Future research should examine enforcement and practical implementation of this framework across Member States to assess its impact on medical device regulation and environmental performance.
{"title":"Mapping the regulatory landscape for environmental sustainability of medical device practices within the European Union.","authors":"Marianna Zarro, Alessia Ferranti, Giulia Garagozzo, Giuseppe Fico, Leandro Pecchia","doi":"10.1093/eurpub/ckaf262","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf262","url":null,"abstract":"<p><p>Regulatory frameworks that integrate environmental sustainability into the lifecycle of medical devices (MDs) are essential to ensure quality, safety, and effectiveness for patients while minimizing environmental impact. The Medical Device Regulation 2017/745/EC (MDR) establishes the core framework for MDs, but additional EU legislation addresses Ecodesign, sustainable packaging, financial incentives, and waste management. Although sustainability is not explicitly included in the MDR, understanding how complementary EU regulations contribute to the European Green Deal agenda is crucial to inform decisionmakers and guide future integration of sustainability principles into medical device governance. We employed a validated policy mapping methodology, derived from the scoping review approach and adapted to systematically identify and analyse regulatory documents from policy repositories rather than academic databases. This method has been previously applied in diverse policy domains, including health, education, and digital innovation. Findings were reported according to the PRISMA-ScR. Eight binding regulations that are either directly applicable or transferable to MDs in the European Union were identified. Together, they introduce requirements on Ecodesign, packaging, financial incentives, and waste management. These complement the MDR framework by embedding sustainability principles into various stages of the MD lifecycle, even though they are not explicitly mandated within the MDR itself. While environmental sustainability provisions remain absent from the MDR, complementary EU regulations create an emerging framework that supports systemic economic transformation in line with the European Green Deal. Future research should examine enforcement and practical implementation of this framework across Member States to assess its impact on medical device regulation and environmental performance.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin Kendzia, Thomas Behrens, Thomas Brüning, Andreas Stang, Karl-Heinz Jöckel, Wolfgang Ahrens
The incidence of germ-cell testicular cancer (TC) has increased in recent decades. Current evidence does not indicate a unanimous association between occupational exposure to welding fumes and TC risk. However, most publications do not provide information on exposure levels to welding fumes. We investigated the association between occupational exposure to welding fumes and the risk of TC in a German case-control study (268 cases and 797 control subjects). A measurement-based welding-exposure matrix was used to estimate year-specific exposure values which were linked to job-task descriptions. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated via logistic regression, conditional on study area and 5-year age groups. ORs were adjusted for a history of cryptorchidism, a family history of TC, and ever exposure to metal-working fluids (MWF). Regular welding was associated with an elevated TC risk (OR: 2.26, CI: 0.92-5.53) compared to occasional welding (OR: 1.14, CI: 0.78-1.69). For non-seminoma, there was an indication of a strong association among regular welders (OR: 3.71, CI: 1.08-12.80) and for non-welders using MWFs (OR: 3.39, CI: 1.21-9.53). However, these estimates were based on few exposed cases. We did not observe dose-effect relationships with increasing lifetime exposure to welding fumes, duration, or average intensity. We found an association between regular welding and TC risk based on standardized job-task descriptions, but not when using the year-specific exposure values.
{"title":"Risk of testicular cancer and exposure to welding fumes.","authors":"Benjamin Kendzia, Thomas Behrens, Thomas Brüning, Andreas Stang, Karl-Heinz Jöckel, Wolfgang Ahrens","doi":"10.1093/eurpub/ckaf255","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf255","url":null,"abstract":"<p><p>The incidence of germ-cell testicular cancer (TC) has increased in recent decades. Current evidence does not indicate a unanimous association between occupational exposure to welding fumes and TC risk. However, most publications do not provide information on exposure levels to welding fumes. We investigated the association between occupational exposure to welding fumes and the risk of TC in a German case-control study (268 cases and 797 control subjects). A measurement-based welding-exposure matrix was used to estimate year-specific exposure values which were linked to job-task descriptions. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated via logistic regression, conditional on study area and 5-year age groups. ORs were adjusted for a history of cryptorchidism, a family history of TC, and ever exposure to metal-working fluids (MWF). Regular welding was associated with an elevated TC risk (OR: 2.26, CI: 0.92-5.53) compared to occasional welding (OR: 1.14, CI: 0.78-1.69). For non-seminoma, there was an indication of a strong association among regular welders (OR: 3.71, CI: 1.08-12.80) and for non-welders using MWFs (OR: 3.39, CI: 1.21-9.53). However, these estimates were based on few exposed cases. We did not observe dose-effect relationships with increasing lifetime exposure to welding fumes, duration, or average intensity. We found an association between regular welding and TC risk based on standardized job-task descriptions, but not when using the year-specific exposure values.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145959107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander Zarour, Christian Bachmann, Lisa Dandolo, Jakob Holstiege, Falk Hoffmann, Constanze Scholman, Yulia Golub
Cannabis use can have detrimental effects on adolescents' mental health, often co-occurring with child and adolescent psychiatric disorders (CAPD). This study assessed diagnostic prevalence trends in cannabis-related disorders and co-occurring diagnosed CAPD in adolescents receiving outpatient treatment in Germany. Outpatient claims data from the national public health insurance system, covering almost 4 million children and adolescents, were assessed for diagnostic prevalence of cannabis-related disorders (ICD-10 diagnoses F12.X) in insurees aged 12 to 17 years for the years 2013-22, stratified by age group and sex. In addition, the diagnostic prevalence of co-occurring CAPD during the year 2022 was evaluated. From 2013 to 2022, the diagnostic prevalence of cannabis-related disorders among German adolescents utilizing outpatient services increased from 0.08% to 0.10% (+22.4%), with a decline during the COVID-19 pandemic and a higher diagnostic prevalence in older adolescents. Up to 14 years of age, the diagnostic prevalence of cannabis-related disorders was distributed evenly among males and females, while from age 15 onwards, the diagnostic prevalence was higher in males. Overall, 78.3% of adolescents diagnosed with cannabis-related disorders had at least one co-occurring CAPD diagnosis in 2022. Most common co-occurring conditions were depressive disorders, conduct disorders, adjustment disorders, attention-deficit/hyperactivity disorders, and anxiety disorders. Co-occurring depression was particularly often diagnosed, underscoring the urgent need for integrated treatment approaches addressing both disorders simultaneously in this age group.
{"title":"Trends in the diagnostic prevalence of cannabis-related disorders and co-occurring psychiatric disorders in adolescents: analysis of German health insurance data from 2013 to 2022.","authors":"Alexander Zarour, Christian Bachmann, Lisa Dandolo, Jakob Holstiege, Falk Hoffmann, Constanze Scholman, Yulia Golub","doi":"10.1093/eurpub/ckaf228","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf228","url":null,"abstract":"<p><p>Cannabis use can have detrimental effects on adolescents' mental health, often co-occurring with child and adolescent psychiatric disorders (CAPD). This study assessed diagnostic prevalence trends in cannabis-related disorders and co-occurring diagnosed CAPD in adolescents receiving outpatient treatment in Germany. Outpatient claims data from the national public health insurance system, covering almost 4 million children and adolescents, were assessed for diagnostic prevalence of cannabis-related disorders (ICD-10 diagnoses F12.X) in insurees aged 12 to 17 years for the years 2013-22, stratified by age group and sex. In addition, the diagnostic prevalence of co-occurring CAPD during the year 2022 was evaluated. From 2013 to 2022, the diagnostic prevalence of cannabis-related disorders among German adolescents utilizing outpatient services increased from 0.08% to 0.10% (+22.4%), with a decline during the COVID-19 pandemic and a higher diagnostic prevalence in older adolescents. Up to 14 years of age, the diagnostic prevalence of cannabis-related disorders was distributed evenly among males and females, while from age 15 onwards, the diagnostic prevalence was higher in males. Overall, 78.3% of adolescents diagnosed with cannabis-related disorders had at least one co-occurring CAPD diagnosis in 2022. Most common co-occurring conditions were depressive disorders, conduct disorders, adjustment disorders, attention-deficit/hyperactivity disorders, and anxiety disorders. Co-occurring depression was particularly often diagnosed, underscoring the urgent need for integrated treatment approaches addressing both disorders simultaneously in this age group.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antimicrobial resistance (AMR) is a growing global health problem. Several public interventions have been designed to increase AMR knowledge and awareness. This review assesses the availability and effectiveness of community-based AMR interventions in Europe. Four databases-Medline (OVID), Pubmed, Scopus, Web of Science- and grey literature were searched for AMR interventions in community settings in Europe between 2000 and 2024. Studies reporting empirical findings in English were considered. A narrative synthesis was performed, and findings were presented in text and tables. Forty-nine studies were eligible for inclusion from 14 European countries. Interventions were primarily educational to raise awareness, targeting individuals, small groups, or the general public through mass campaigns, school-based programmes, online games, and pledges. Some interventions also monitored adherence, consumption, and doctor consultation. The majority of interventions reported increased knowledge and awareness of antibiotics and AMR; reduced antibiotic prescription, purchase, use, and non-compliance; reduced respiratory incidence and doctor consultations, and increased overall adherence. Fluctuations in knowledge over time were observed, but evidence was insufficient to analyse the long-term sustainability of outcomes of the interventions. Our findings show that community-based interventions can enhance knowledge and awareness of appropriate antibiotic use and AMR risks among different population groups. These can also positively improve adherence, expectation, and prescribing. However, long-term engagement and interventions are needed to attain sustainability and bring behavioural changes.
抗菌素耐药性(AMR)是一个日益严重的全球卫生问题。一些公共干预措施旨在提高抗菌素耐药性的知识和认识。本综述评估了欧洲社区抗菌素耐药性干预措施的可得性和有效性。我们检索了四个数据库——medline (OVID)、Pubmed、Scopus、Web of Science和灰色文献,以查找2000年至2024年间欧洲社区环境中的AMR干预措施。考虑了用英语报告实证结果的研究。进行了叙述综合,并以文本和表格的形式提出了调查结果。来自14个欧洲国家的49项研究符合纳入条件。干预措施主要是教育性的,以提高认识为目标,针对个人、小团体或公众,通过大规模运动、学校规划、在线游戏和认捐。一些干预措施还监测依从性、消费和医生咨询。大多数干预措施报告提高了对抗生素和抗菌素耐药性的认识和认识;减少抗生素处方、购买、使用和不合规;减少呼吸道疾病的发病率和医生咨询,提高总体依从性。观察到知识随时间的波动,但证据不足,无法分析干预措施结果的长期可持续性。我们的研究结果表明,以社区为基础的干预措施可以提高不同人群对抗生素适当使用和抗菌素耐药性风险的认识和认识。这些也可以积极地提高依从性、期望和处方。然而,需要长期参与和干预才能实现可持续性并带来行为改变。
{"title":"Community-based interventions for management of antimicrobial resistance in Europe: a systematic review.","authors":"Winifred Ekezie, Mayuri Gogoi, Nataly Papadopoulou, Farah Badakshi, Karen J Bowman, Beauty Igein, Manish Pareek","doi":"10.1093/eurpub/ckaf257","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf257","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) is a growing global health problem. Several public interventions have been designed to increase AMR knowledge and awareness. This review assesses the availability and effectiveness of community-based AMR interventions in Europe. Four databases-Medline (OVID), Pubmed, Scopus, Web of Science- and grey literature were searched for AMR interventions in community settings in Europe between 2000 and 2024. Studies reporting empirical findings in English were considered. A narrative synthesis was performed, and findings were presented in text and tables. Forty-nine studies were eligible for inclusion from 14 European countries. Interventions were primarily educational to raise awareness, targeting individuals, small groups, or the general public through mass campaigns, school-based programmes, online games, and pledges. Some interventions also monitored adherence, consumption, and doctor consultation. The majority of interventions reported increased knowledge and awareness of antibiotics and AMR; reduced antibiotic prescription, purchase, use, and non-compliance; reduced respiratory incidence and doctor consultations, and increased overall adherence. Fluctuations in knowledge over time were observed, but evidence was insufficient to analyse the long-term sustainability of outcomes of the interventions. Our findings show that community-based interventions can enhance knowledge and awareness of appropriate antibiotic use and AMR risks among different population groups. These can also positively improve adherence, expectation, and prescribing. However, long-term engagement and interventions are needed to attain sustainability and bring behavioural changes.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145984789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pol Rovira, Taavi Lai, Rainer Reile, Ahmed S Hassan, Jürgen Rehm
Estonia is planning an update of its national alcohol policies where an economic return on investment (ROI) analysis is needed to guide decisions against their monetary returns. Using mostly national data sources, the ROI analysis was based on direct healthcare costs and productivity losses due to premature mortality. The interventions compared comprised availability restrictions and taxation increases. For taxation increases, associated revenue increases to government were included. All analyses used a one-year time horizon and different sensitivity analyses. In 2023, all alcohol-attributable harms in Estonia totalled €510.00 million (1.3% of the Gross Domestic Product of Estonia) with €263.91 million direct costs and €246.08 million indirect costs. The proposed availability reductions are expected to yield a net benefit of €6.33 million, whereas a 15% increase in alcohol excise taxation could lower healthcare costs and productivity losses by €1.77 million in addition to increasing tax revenue by €32.27 million. Moreover, the interventions were estimated to lead to substantial reductions in mortality and hospitalizations. In terms of ROI, the availability interventions would result in €15 gained for each euro invested, and the taxation increase in €477 per euro invested, and without revenue in €25 per euro invested. Positive ROI was also shown in all sensitivity analyses. The proposed alcohol control policies for Estonia would not only reduce mortality and morbidity but also bring sizeable gains for each euro invested. Higher ROI for taxation increase compared to availability restrictions was mainly due to the added tax revenue.
{"title":"Using a return on investment analysis to estimate the economic impact of potential changes to alcohol control policies in Estonia.","authors":"Pol Rovira, Taavi Lai, Rainer Reile, Ahmed S Hassan, Jürgen Rehm","doi":"10.1093/eurpub/ckaf265","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf265","url":null,"abstract":"<p><p>Estonia is planning an update of its national alcohol policies where an economic return on investment (ROI) analysis is needed to guide decisions against their monetary returns. Using mostly national data sources, the ROI analysis was based on direct healthcare costs and productivity losses due to premature mortality. The interventions compared comprised availability restrictions and taxation increases. For taxation increases, associated revenue increases to government were included. All analyses used a one-year time horizon and different sensitivity analyses. In 2023, all alcohol-attributable harms in Estonia totalled €510.00 million (1.3% of the Gross Domestic Product of Estonia) with €263.91 million direct costs and €246.08 million indirect costs. The proposed availability reductions are expected to yield a net benefit of €6.33 million, whereas a 15% increase in alcohol excise taxation could lower healthcare costs and productivity losses by €1.77 million in addition to increasing tax revenue by €32.27 million. Moreover, the interventions were estimated to lead to substantial reductions in mortality and hospitalizations. In terms of ROI, the availability interventions would result in €15 gained for each euro invested, and the taxation increase in €477 per euro invested, and without revenue in €25 per euro invested. Positive ROI was also shown in all sensitivity analyses. The proposed alcohol control policies for Estonia would not only reduce mortality and morbidity but also bring sizeable gains for each euro invested. Higher ROI for taxation increase compared to availability restrictions was mainly due to the added tax revenue.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paula Del Rey Puech, Natasha Azzopardi Muscat, Charlotte Marchandise, Martin McKee
{"title":"Reclaiming trust: public health action to counter the infodemic.","authors":"Paula Del Rey Puech, Natasha Azzopardi Muscat, Charlotte Marchandise, Martin McKee","doi":"10.1093/eurpub/ckaf249","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf249","url":null,"abstract":"","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marjan Meurisse, Francisco Estupiñán-Romero, Markus Perola, Teemu Paajanen, Javier González-Galindo, Nina Van Goethem, Enrique Bernal-Delgado
To assess the impact of large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination campaigns in real-world settings across regions, we performed a reproducible cross-border comparison of the real-world effectiveness of primary vaccination in preventing SARS-CoV-2 infections across three sites: Aragon (Spain), Brussels and Wallonia (Belgium), and Finland. This observational study emulated a target trial by daily matching primary vaccinated individuals 1:1 to un- or partially vaccinated individuals using propensity scores estimated on a set of relevant confounders from January to September 2021. Matched individuals were followed up until a SARS-CoV-2 infection was contracted or a censoring event occurred. Vaccine effectiveness in preventing infections was estimated by the difference in restricted mean survival time (RMST). Primary vaccination extended the average free-of-infection time by 35.9 [95% confidence interval (CI) (34.9-37.0)], 59.6 [95% CI (59.3-60.0)], and 1.6 [95% CI (1.1-2.0)] days over 365 days in the population cohort of Aragon (Spain), Brussels and Wallonia (Belgium), and Finland, respectively. This federated population-based observational study showed the effectiveness of the SARS-CoV-2 primary vaccination campaign in prolonging the mean time to infection in the Aragon (Spain) and Brussels and Wallonia (Belgium) population cohorts. Only a minor difference over this time frame was found in Finland's population cohort.
{"title":"Real-world comparative effectiveness of SARS-CoV-2 primary vaccination campaigns against SARS-CoV-2 infections: a federated observational study emulating a target trial in three nations.","authors":"Marjan Meurisse, Francisco Estupiñán-Romero, Markus Perola, Teemu Paajanen, Javier González-Galindo, Nina Van Goethem, Enrique Bernal-Delgado","doi":"10.1093/eurpub/ckaf247","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf247","url":null,"abstract":"<p><p>To assess the impact of large-scale severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination campaigns in real-world settings across regions, we performed a reproducible cross-border comparison of the real-world effectiveness of primary vaccination in preventing SARS-CoV-2 infections across three sites: Aragon (Spain), Brussels and Wallonia (Belgium), and Finland. This observational study emulated a target trial by daily matching primary vaccinated individuals 1:1 to un- or partially vaccinated individuals using propensity scores estimated on a set of relevant confounders from January to September 2021. Matched individuals were followed up until a SARS-CoV-2 infection was contracted or a censoring event occurred. Vaccine effectiveness in preventing infections was estimated by the difference in restricted mean survival time (RMST). Primary vaccination extended the average free-of-infection time by 35.9 [95% confidence interval (CI) (34.9-37.0)], 59.6 [95% CI (59.3-60.0)], and 1.6 [95% CI (1.1-2.0)] days over 365 days in the population cohort of Aragon (Spain), Brussels and Wallonia (Belgium), and Finland, respectively. This federated population-based observational study showed the effectiveness of the SARS-CoV-2 primary vaccination campaign in prolonging the mean time to infection in the Aragon (Spain) and Brussels and Wallonia (Belgium) population cohorts. Only a minor difference over this time frame was found in Finland's population cohort.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145931577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We examined sociodemographic, clinical, and functional characteristics influencing avoidable and unavoidable hospital admissions in older adults over 15 years. The study included 3166 participants aged 60+ years from the Swedish National Study on Aging and Care in Kungsholmen. Hospital admissions were identified through national registers and classified as avoidable using official Swedish criteria. Multistate models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for both admission types. During the 15-year follow-up, the incidence rates of avoidable and unavoidable hospital admissions were, respectively, 5.74 and 35.17 per 100 person-years. Avoidable admissions due to chronic conditions were more common than those due to acute conditions (3.94 vs. 1.80 per 100 person-years over 15 years). Women had lower risk of both avoidable and unavoidable admissions compared to men (HRs range 0.46-0.76), while being unpartnered increased the risk for both hospitalization types (HRs range 1.13-1.33). Receiving formal care lowered the risk of unavoidable admissions (HR 0.78, 95% CI 0.73-0.84), whereas informal care increased the likelihood of avoidable admissions due to chronic condition (HRs range 1.17-1.34). Multimorbidity, slow gait speed, and polypharmacy associated strongly with avoidable admissions (HRs range 1.41-2.50). Conversely, cognitive impairment and disability lowered risk of avoidable admissions for chronic conditions (HRs range 0.62-0.83). Multimorbidity, slow gait speed, and polypharmacy predicted higher risks for avoidable admissions from chronic conditions, while disability and cognitive impairment showed lower risks. These findings underscore the need for timely and comprehensive evaluation strategies to reduce the burden of avoidable hospital care.
我们研究了影响15岁以上老年人可避免和不可避免住院的社会人口学、临床和功能特征。这项研究包括了3166名60岁以上的参与者,他们来自瑞典Kungsholmen国家老龄化和护理研究。通过国家登记册确定住院情况,并根据瑞典官方标准将其归类为可避免的住院情况。多状态模型估计了两种入院类型的风险比(hr)和95%置信区间(ci)。在15年的随访期间,可避免和不可避免的住院率分别为5.74和35.17 / 100人年。可避免的慢性疾病入院比急性疾病更常见(15年内每100人年3.94比1.80)。与男性相比,女性可避免和不可避免入院的风险较低(hr范围为0.46-0.76),而单身则增加了两种住院类型的风险(hr范围为1.13-1.33)。接受正规护理降低了不可避免入院的风险(HR 0.78, 95% CI 0.73-0.84),而非正规护理增加了因慢性疾病而不可避免入院的可能性(HR范围1.17-1.34)。多病、慢步速和多药与可避免入院密切相关(hr范围1.41-2.50)。相反,认知障碍和残疾降低了慢性疾病可避免入院的风险(hr范围为0.62-0.83)。多病、慢速步态和多药预示着可避免的慢性病入院风险较高,而残疾和认知障碍的风险较低。这些发现强调需要及时和全面的评估策略,以减轻可避免的医院护理的负担。
{"title":"Predictors of avoidable and unavoidable hospital admissions in older adults: a 15-year population-based cohort study.","authors":"Susanna Gentili, Giuliana Locatelli, Rino Bellocco, Amaia Calderón-Larrañaga, Debora Rizzuto, Megan Doheny, Carin Lennartsson, Åsa Hedberg-Rundgren, Laura Fratiglioni, Davide L Vetrano","doi":"10.1093/eurpub/ckaf264","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf264","url":null,"abstract":"<p><p>We examined sociodemographic, clinical, and functional characteristics influencing avoidable and unavoidable hospital admissions in older adults over 15 years. The study included 3166 participants aged 60+ years from the Swedish National Study on Aging and Care in Kungsholmen. Hospital admissions were identified through national registers and classified as avoidable using official Swedish criteria. Multistate models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for both admission types. During the 15-year follow-up, the incidence rates of avoidable and unavoidable hospital admissions were, respectively, 5.74 and 35.17 per 100 person-years. Avoidable admissions due to chronic conditions were more common than those due to acute conditions (3.94 vs. 1.80 per 100 person-years over 15 years). Women had lower risk of both avoidable and unavoidable admissions compared to men (HRs range 0.46-0.76), while being unpartnered increased the risk for both hospitalization types (HRs range 1.13-1.33). Receiving formal care lowered the risk of unavoidable admissions (HR 0.78, 95% CI 0.73-0.84), whereas informal care increased the likelihood of avoidable admissions due to chronic condition (HRs range 1.17-1.34). Multimorbidity, slow gait speed, and polypharmacy associated strongly with avoidable admissions (HRs range 1.41-2.50). Conversely, cognitive impairment and disability lowered risk of avoidable admissions for chronic conditions (HRs range 0.62-0.83). Multimorbidity, slow gait speed, and polypharmacy predicted higher risks for avoidable admissions from chronic conditions, while disability and cognitive impairment showed lower risks. These findings underscore the need for timely and comprehensive evaluation strategies to reduce the burden of avoidable hospital care.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
María Alonso-Colon, Sara Moreno-García, Juan Miguel Guerras, Marta Donat, Paule Gonzalez-Recio, María José Belza
Trans and non-binary individuals are particularly vulnerable to discrimination in public spaces, workplaces, housing, and healthcare. The exclusion they experience also affects their participation in physical activity (PA). This study aimed to estimate the proportion of trans and non-binary individuals living in Spain that engage in PA several times per week and to explore potential associated factors. A cross-sectional study was conducted using data from 1473 participants aged 15 or older, recruited between October 2023 and March 2024 through an online national survey on trans and non-binary health. PA engagement was estimated with 95% confidence intervals (95% CIs). A Poisson regression model with robust variance was used to identify associated factors, obtaining adjusted prevalence ratios (aPRs) with 95% CI. Overall, 23.2% (95% CI: 21.1%-25.5%) reported engaging in PA several times per week. In the adjusted analysis, PA was less common among trans women (aPR = 0.46, 95% CI 0.35-0.62) and non-binary individuals (aPR = 0.67, 95% CI 0.52-0.85) compared to transmasculine individuals. Lower PA levels were also observed in those unable to legally change their name due to barriers (aPR = 0.71, 95% CI 0.52-0.97), and those with mental health issues in the past year (aPR = 0.76, 95% CI 0.62-0.93). Higher PA participation was associated with being ≥29 years old (aPR = 1.41, 95% CI 1.08-1.84) and better self-perceived health (aPR = 1.33, 95% CI 1.07-1.65). Trans women and non-binary individuals engage in PA less frequently. Sociodemographic factors, health, and legal barriers significantly impact PA participation. Policies should encourage PA, especially among young trans individuals, and ensure equitable and discrimination-free access.
跨性别者和非二元性别者在公共场所、工作场所、住房和医疗保健领域尤其容易受到歧视。他们所经历的排斥也影响了他们参与体育活动(PA)。本研究旨在估计居住在西班牙的跨性别和非二元性个体每周进行几次PA的比例,并探讨潜在的相关因素。一项横断面研究使用了1473名15岁及以上的参与者的数据,这些参与者是在2023年10月至2024年3月期间通过一项关于跨性别和非二元健康的在线全国调查招募的。以95%置信区间(95% ci)估计PA的参与情况。使用具有稳健方差的泊松回归模型确定相关因素,获得校正患病率(aPRs), 95% CI。总体而言,23.2% (95% CI: 21.1%-25.5%)报告每周参加几次PA。在校正分析中,与跨性别个体相比,跨性别女性(aPR = 0.46, 95% CI 0.35-0.62)和非二元个体(aPR = 0.67, 95% CI 0.52-0.85)中PA的发生率较低。由于障碍而无法合法更改姓名的人(aPR = 0.71, 95% CI 0.52-0.97)和过去一年有精神健康问题的人(aPR = 0.76, 95% CI 0.62-0.93)的PA水平也较低。较高的PA参与与≥29岁(aPR = 1.41, 95% CI 1.08-1.84)和更好的自我感知健康(aPR = 1.33, 95% CI 1.07-1.65)相关。跨性别女性和非二元性个体较少参与PA。社会人口因素、健康和法律障碍显著影响PA的参与。政策应该鼓励PA,特别是在年轻的跨性别者中,并确保公平和无歧视的准入。
{"title":"Physical activity differences in trans and non-binary people: the role of health, social, and legal barriers.","authors":"María Alonso-Colon, Sara Moreno-García, Juan Miguel Guerras, Marta Donat, Paule Gonzalez-Recio, María José Belza","doi":"10.1093/eurpub/ckaf244","DOIUrl":"https://doi.org/10.1093/eurpub/ckaf244","url":null,"abstract":"<p><p>Trans and non-binary individuals are particularly vulnerable to discrimination in public spaces, workplaces, housing, and healthcare. The exclusion they experience also affects their participation in physical activity (PA). This study aimed to estimate the proportion of trans and non-binary individuals living in Spain that engage in PA several times per week and to explore potential associated factors. A cross-sectional study was conducted using data from 1473 participants aged 15 or older, recruited between October 2023 and March 2024 through an online national survey on trans and non-binary health. PA engagement was estimated with 95% confidence intervals (95% CIs). A Poisson regression model with robust variance was used to identify associated factors, obtaining adjusted prevalence ratios (aPRs) with 95% CI. Overall, 23.2% (95% CI: 21.1%-25.5%) reported engaging in PA several times per week. In the adjusted analysis, PA was less common among trans women (aPR = 0.46, 95% CI 0.35-0.62) and non-binary individuals (aPR = 0.67, 95% CI 0.52-0.85) compared to transmasculine individuals. Lower PA levels were also observed in those unable to legally change their name due to barriers (aPR = 0.71, 95% CI 0.52-0.97), and those with mental health issues in the past year (aPR = 0.76, 95% CI 0.62-0.93). Higher PA participation was associated with being ≥29 years old (aPR = 1.41, 95% CI 1.08-1.84) and better self-perceived health (aPR = 1.33, 95% CI 1.07-1.65). Trans women and non-binary individuals engage in PA less frequently. Sociodemographic factors, health, and legal barriers significantly impact PA participation. Policies should encourage PA, especially among young trans individuals, and ensure equitable and discrimination-free access.</p>","PeriodicalId":12059,"journal":{"name":"European Journal of Public Health","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}