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Physical activity partially mediates the association between health literacy and mild cognitive impairment in older adults: cross-sectional evidence from Switzerland. 身体活动部分介导老年人健康素养与轻度认知障碍之间的关联:来自瑞士的横断面证据。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae209
Clément Meier, Maud Wieczorek, Damaris Aschwanden, Andreas Ihle, Matthias Kliegel, Jürgen Maurer

Individuals' health literacy (HL) is positively associated with healthy behaviors and global cognitive functioning. Current evidence also suggests that physical activity may prevent or delay cognitive decline and dementia. This study examines the potential mediating role of physical activity in the association between HL and cognition in a population-based sample of adults aged 58+ in Switzerland. We used data from 1645 respondents to Wave 8 (2019/2020) of the Survey on Health, Ageing, and Retirement in Europe in Switzerland. HL was assessed using the HLS-EU-Q16 questionnaire. Mild cognitive impairment (MCI) was defined as a 1.5 SD below the mean of age- and education-specific global cognition score. The frequency of moderate and vigorous physical activity was self-reported. The associations were assessed using probit regression models, controlling for social, health, and regional characteristics. Structural equation modeling was used to test the mediation hypothesis. Higher HL was associated with a higher likelihood of being engaged in moderate (P < .001) and vigorous (P < .01) physical activity and with a lower likelihood of having MCI (P < .05). In addition, both moderate (P < .05) and vigorous (P < .01) physical activity were associated with a lower probability of having MCI. Mediation analysis indicated that the association between HL and MCI was partially mediated by both moderate (12.9%) and vigorous (6.7%) physical activity. Given that physical activity may partially mediate the association between HL and MCI, improving HL in older adults could potentially foster engagement in physical activity, which could, in turn, act as a protective factor against MCI.

个体健康素养与健康行为和整体认知功能呈正相关。目前的证据还表明,体育活动可以预防或延缓认知能力下降和痴呆。本研究以瑞士58岁以上的成年人为样本,探讨了体育活动在HL和认知之间的关联中的潜在中介作用。我们使用了瑞士欧洲健康、老龄化和退休调查第8轮(2019/2020)的1645名受访者的数据。采用HLS-EU-Q16问卷评估HL。轻度认知障碍(MCI)被定义为低于年龄和教育水平的整体认知得分平均值1.5 SD。中度和剧烈体育活动的频率是自我报告的。在控制社会、健康和区域特征的情况下,使用概率回归模型评估这些关联。采用结构方程模型对中介假设进行检验。HL越高,参与中度疼痛的可能性越高(P
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引用次数: 0
Public Health, One Health, and Planetary Health: what is next? 公共卫生、"一体健康 "和 "行星健康":下一步是什么?
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae149
Francisco Olea-Popelka, Nicole Redvers, Saverio Stranges
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引用次数: 0
The association between tobacco use and COVID-19 diagnoses in three Nordic countries: a pooled analysis. 北欧三国烟草使用与 COVID-19 诊断之间的关系:汇总分析。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae156
Ahmed Nabil Shaaban, Filip Andersson, Robert Thiesmeier, Nicola Orsini, Sebastian Peña, Ida Henriette Caspersen, Cecilia Magnusson, Sakari Karvonen, Per Minor Magnus, Maria Pia Hergens, Basra Qazi, Maria Rosaria Galanti

Previous research has suggested an unexpected negative association between smoking and susceptibility to COVID-19. This study, drawing on population-based data from three Nordic countries-Sweden, Norway, and Finland-aims to investigate this association further, capitalizing on diversity introduced by different containment measures. The objective of this research was to examine the association between cigarette smoking and snus (smokeless tobacco) use and the risk of confirmed COVID-19 infection. A pooled analysis integrating original data from 547,685 participants across three countries. We used a multiple imputation approach based on conditional probabilities to impute the systematically missing covariates. The associations between tobacco use and COVID-19 infection were assessed, controlling for potential confounding factors. Current cigarette smokers had a lower risk of a confirmed COVID-19 case, whereas there was an increased risk among snus users. Our sensitivity analysis confirmed that the associations between tobacco use and COVID-19 infection risk are robust, remaining consistent regardless of whether covariate imputation was applied. Findings support a negative association between smoking and SARS-CoV-2 infection, but not the hypothesis that nicotine may be protective against the risk of contracting SARS-CoV-2 infection.

以前的研究表明,吸烟与 COVID-19 易感性之间存在意想不到的负相关。本研究利用瑞典、挪威和芬兰这三个北欧国家的人口数据,旨在利用不同遏制措施带来的多样性,进一步研究这种关联。本研究的目的是探讨吸烟和吸食鼻烟(无烟烟草)与确诊 COVID-19 感染风险之间的关系。我们对三个国家 547,685 名参与者的原始数据进行了汇总分析。我们采用了基于条件概率的多重估算方法来估算系统缺失的协变量。在控制潜在混杂因素的情况下,我们评估了吸烟与 COVID-19 感染之间的关系。目前吸烟的人感染 COVID-19 确诊病例的风险较低,而吸食鼻烟的人感染 COVID-19 的风险较高。我们的敏感性分析证实,烟草使用与COVID-19感染风险之间的关系是稳健的,无论是否应用协变量估算,两者之间的关系都是一致的。研究结果支持吸烟与SARS-CoV-2感染之间的负相关,但不支持尼古丁可降低感染SARS-CoV-2风险的假设。
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引用次数: 0
Association between job strain and working life expectancy: a longitudinal study of older people in Sweden. 工作压力与工作寿命之间的关系:瑞典老年人的纵向研究。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae186
Holendro Singh Chungkham, Robin Högnäs, Kristina Alexanderson, Paola Zaninotto, Kristin Farrants, Martin Hyde, Linda L Magnusson Hanson, Jenny Head, Reiner Rugulies, Ann Dyreborg Larsen, Anushiya Vanajan, Sari Stenholm, Hugo Westerlund

Many European countries have increased retirement ages to address the challenge of population ageing. However, job strain which is the combination of high job demands and low job control may be an obstacle to extending the working lives of older workers. Job strain is associated with poor health and early work exit among older workers, but less is known about whether job strain impacts working life expectancy (WLE)-an increasingly employed summary measure capturing the length of working lives. This study aims to fill this gap in the literature. The sample included n = 13 225 individuals aged 50 years or older at baseline providing 53 004 persons-observations from the Swedish Longitudinal Occupational Survey of Health in 2008 through 2020. We used continuous time multi-state Markov models to assess the average number of years people may be expected to work beyond age 50 years by job strain, and stratified by sex, occupational class, and level of education. Job strain was associated with a significantly shorter WLE (by about 6 months to a year) among those who experienced job strain compared to those who did not experience job strain. Our findings suggest that job strain may play a role in shortening the working lives of older people. The findings further suggest that if older workers are to remain in the labor market for longer periods, this may require improvements of psychosocial working conditions.

许多欧洲国家提高了退休年龄,以应对人口老龄化的挑战。然而,工作压力是高工作要求和低工作控制的结合,可能是延长老年工人工作寿命的障碍。在老年员工中,工作压力与健康状况不佳和过早离职有关,但工作压力是否会影响工作寿命(WLE)——一种越来越多使用的衡量工作寿命长短的综合指标——却鲜为人知。本研究旨在填补这一文献空白。样本包括n = 13 225名50岁或以上的个体,提供了2008年至2020年瑞典纵向职业健康调查中53004人的观察结果。我们使用连续时间多状态马尔可夫模型来评估人们在50岁以上可能工作的平均年数,并按性别、职业类别和教育水平分层。与没有工作压力的人相比,工作压力与较短的WLE相关(大约6个月到一年)。我们的研究结果表明,工作压力可能会缩短老年人的工作寿命。研究结果进一步表明,如果老年工人要在劳动力市场上停留更长时间,这可能需要改善社会心理工作条件。
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引用次数: 0
How to prevent 3 million deaths worldwide: a systematic review of occupational accident research-a factor- and cost-based approach. 如何防止全世界300万人死亡:对职业事故研究的系统回顾——基于因素和成本的方法。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae197
Rosa María Cañaveras Perea, Ángel Tejada Ponce, María Pilar Sánchez González

Occupational accidents have emerged as a global concern, necessitating a comprehensive examination of their determinants and associated costs. This review aims to summarize, synthesize, and organize the factors and cost drivers of occupational accidents, exploring whether there is a gender perspective. Adhering to PRISMA guidelines, we performed a narrative synthesis to systematically review relevant literature. A systematic search was conducted in the electronic databases PubMed, Web of Science, and Scopus. Two researchers screened all records to eliminate any duplicates, and they selected the articles for full review. A third researcher was consulted to resolve discrepancies and reach a consensus. The analysis of 15 studies revealed diverse perspectives; in terms of determinants, studies on organizational aspects and the theory of human error were grouped together, while in cost drivers, the human capital model and willingness to pay were the most frequently used. Gender, meanwhile, is identified as a determinant variable for accident rate. Additionally, limitations such as data underestimation were noted in the existing literature. The review highlights the need for empirical studies capable of addressing both determinants and cost drivers. It also provides guidelines for researchers to design studies that are more comparable across different contexts, including the gender debate.

职业事故已成为全球关注的问题,因此有必要对其决定因素和相关成本进行全面研究。本综述旨在总结、归纳和整理职业事故的因素和成本驱动因素,并探讨是否存在性别视角。根据 PRISMA 指南,我们进行了叙述性综述,系统地回顾了相关文献。我们在电子数据库 PubMed、Web of Science 和 Scopus 中进行了系统检索。两名研究人员对所有记录进行了筛选,以去除任何重复内容,并挑选出文章进行全面综述。他们还咨询了第三位研究人员,以解决差异并达成共识。对 15 项研究的分析显示了不同的观点;在决定因素方面,有关组织方面和人为错误理论的研究被归为一组,而在成本驱动因素方面,人力资本模型和支付意愿是最常用的。同时,性别被认为是事故率的一个决定性变量。此外,现有文献还指出了数据估计不足等局限性。本综述强调,有必要开展能够解决决定因素和成本驱动因素的实证研究。它还为研究人员提供了指导方针,以便设计出在不同情况下更具可比性的研究,包括性别辩论。
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引用次数: 0
The contribution of common mental disorders and alcohol-related morbidity to educational differences in early labour market exit among older workers: a register-based cohort study. 老年工人早期退出劳动力市场时常见精神障碍和酒精相关发病率对教育差异的贡献:一项基于登记的队列研究。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae212
Emma Carlsson, Tomas Hemmingsson, Jonas Landberg, Bo Burström, Emelie Thern

Previous studies have identified educational differences in early labour market exits, yet the mechanisms behind these disparities remain unclear. This study aims to examine to what extent common mental disorders (CMD) and alcohol-related morbidity can explain educational differences in early labour market exit. This cohort study included all men born 1951-53 who underwent conscription examination for military service in Sweden at age 18-20 (n = 136 466). The highest level of educational attainment and early labour market exit, using five different exit routes, was obtained from nationwide registers. Mediation analysis was used to examine the contribution of CMD and alcohol-related morbidity to the educational differences in early labour market exit. Factors measured in childhood, late adolescence, and early adulthood were included as confounders. Lower-educated men were at higher risk of leaving the labour market early. CMD contributed marginally to the educational differences in early exit due to disability pension, long-term sickness absence, and long-term unemployment, explaining up to 4%. Alcohol-related morbidity explained up to 12% of the educational differences in disability pension, long-term sickness absence, and long-term unemployment. Neither CMD nor alcohol-related morbidity were associated with early old-age retirement with and without income. Alcohol-related morbidity appears to be of importance when trying to understand educational differences in some but not all early labour market exit routes. Thus, reducing the negative effects of alcohol consumption could reduce educational inequalities in early exits from the labour market and prolong working life for all individuals regardless of socioeconomic position.

先前的研究已经确定了早期劳动力市场退出的教育差异,但这些差异背后的机制尚不清楚。本研究旨在检验常见精神障碍(CMD)和酒精相关发病率在多大程度上可以解释早期劳动力市场退出的教育差异。本队列研究纳入了所有出生于1951- 1953年、18-20岁在瑞典接受征兵检查的男性(n = 136466)。通过五种不同的退出途径,从全国登记册中获得了最高程度的教育程度和早期劳动力市场退出。使用中介分析来检验CMD和酒精相关发病率对早期劳动力市场退出的教育差异的贡献。在儿童期、青春期晚期和成年早期测量的因素被包括在混杂因素中。受教育程度较低的男性提前离开劳动力市场的风险更高。由于残疾抚恤金、长期病假和长期失业,CMD对早期退出的教育差异贡献很小,解释了高达4%。在残疾养恤金、长期病假和长期失业方面,与酒精有关的发病率可解释高达12%的教育差异。CMD和酒精相关的发病率都与有收入和无收入的提前退休无关。在试图理解某些但不是所有早期劳动力市场退出途径的教育差异时,与酒精有关的发病率似乎很重要。因此,减少酒精消费的负面影响可以减少早期退出劳动力市场时的教育不平等,并延长所有个人的工作寿命,无论其社会经济地位如何。
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引用次数: 0
Preventing common mental health problems by increasing neighbourhood socioeconomic status: a mental health impact assessment in Rotterdam, the Netherlands. 通过提高社区社会经济地位来预防常见的心理健康问题:荷兰鹿特丹的心理健康影响评估。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae222
Daina Kosīte, Frank J van Lenthe, Mark J Nieuwenhuijsen, Mariëlle A Beenackers

Neighbourhood socioeconomic status (NSES) has been identified as a determinant of mental health. In this study, we aimed to quantify how many cases of common mental health problems could be prevented by increasing NSES in the most socioeconomically deprived neighbourhoods in Rotterdam, the Netherlands, and how the increases in NSES would affect mental health inequalities. We used publicly available data for conducting a quantitative Health Impact Assessment (HIA) of two counterfactual policy scenarios. In Scenario 1, we set the NSES to the Rotterdam median score for all neighbourhoods which were below the Rotterdam median. In Scenario 2, we set the NSES score to the Dutch national average socioeconomic status score for the neighbourhoods that were below the national average. We estimated that Scenario 1 could prevent 5847 (95% CI, 2700-7999) or 10.7% of annual cases of common mental health problems, and Scenario 2 could prevent 10 713 (95% CI, 4875-14 799) or 19.6% of annual cases in Rotterdam while also reducing mental health inequalities between neighbourhoods in both scenarios. Given the substantial improvements in population mental health that enhanced neighbourhood socioeconomic conditions would bring, policy implementation is urgently needed.

社区社会经济地位(NSES)已被确定为心理健康的决定因素。在这项研究中,我们旨在量化在荷兰鹿特丹最社会经济贫困的社区中,通过增加NSES可以预防多少常见的心理健康问题,以及NSES的增加如何影响心理健康不平等。我们使用公开数据对两种反事实政策情景进行定量健康影响评估(HIA)。在场景1中,我们将NSES设置为低于鹿特丹中位数的所有社区的鹿特丹中位数得分。在场景2中,我们将NSES得分设置为低于全国平均水平的社区的荷兰全国平均社会经济地位得分。我们估计,在鹿特丹,情景1可以预防5847例(95% CI, 2700-7999)或10.7%的年度常见心理健康问题病例,而情景2可以预防10713例(95% CI, 4875- 14799)或19.6%的年度病例,同时也减少了两种情景中社区之间的心理健康不平等。鉴于社区社会经济条件的改善将大大改善人口心理健康,因此迫切需要执行政策。
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引用次数: 0
Prospective relationship between family screen time rules, obesogenic behaviours, and childhood obesity. 家庭屏幕时间规定、肥胖行为和儿童肥胖之间的前瞻性关系。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae169
Ladan Hashemi, Maryam Ghasemi, Deborah Schlichting, Maryam Pirouzi, Cameron Grant, Boyd Swinburn

Family screen use rules (FSRs) could plausibly protect against the development of childhood obesity, although the mechanisms underlying these protective effects remain largely unexplored. This research aimed to investigate prospectively the associations between exposure to FSRs at age 24 months, obesogenic behaviours (excessive screen time and short sleep duration) at age 45 months, and obesity at age 54 months. Additionally, a model proposing the mediating role of obesogenic behaviours in the association between FSRs and childhood obesity was tested. Data were obtained from 5733 children and their mothers participating in the 'Growing Up in New Zealand' study. Logistic regressions examined the association between three FSRs (rules on quality, quantity and timing of screen time, and different numbers of FSRs), obesogenic behaviours, and childhood obesity. Structural equation modelling (SEM) was applied to assess the potential mediating roles of obesogenic behaviours in the association between FSRs and zBMI. Neither exposure to individual nor all three FSRs was significantly associated with lower odds of obesity. However, protective effects of FSRs were observed concerning obesogenic behaviours. Exposure to individual or all three FSRs correlated with reduced odds of not meeting screen time and sleep duration recommendations. SEM analysis indicated no direct association between FSRs and zBMI; nevertheless, a significant indirect association was identified through the mediation of obesogenic behaviours. These findings suggest the potential benefits of promoting the adoption of FSRs as a promising population-based strategy to enhance child health behaviours and mitigate the risk of childhood obesity.

家庭屏幕使用规则(FSRs)可以有效防止儿童肥胖症的发生,但这些保护作用的内在机制在很大程度上仍未得到探讨。本研究旨在前瞻性地调查 24 个月大时接触家庭屏幕使用规则、45 个月大时肥胖行为(屏幕使用时间过长和睡眠时间过短)与 54 个月大时肥胖之间的关联。此外,该研究还测试了一个模型,该模型提出了致肥胖行为在FSR与儿童肥胖之间的关联中的中介作用。数据来自 5733 名参加 "新西兰成长 "研究的儿童及其母亲。逻辑回归检验了三种 FSR(关于屏幕时间的质量、数量和时间的规则,以及不同数量的 FSR)、致肥行为和儿童肥胖之间的关联。应用结构方程模型(SEM)评估了致肥胖行为在FSR与zBMI之间关系中的潜在中介作用。无论是接触单个还是所有三个家庭健康状况报告,都与降低肥胖几率无明显关联。然而,在致肥胖行为方面观察到了 FSR 的保护作用。接触单个或所有三个FSR与未达到屏幕时间和睡眠时间建议的几率降低有关。SEM 分析表明,FSR 与 zBMI 之间没有直接联系;但是,通过对致肥行为的调解,发现两者之间存在显著的间接联系。这些研究结果表明,推广采用家庭健康参考标准是一项很有前景的人群策略,可以改善儿童的健康行为,降低儿童肥胖的风险,具有潜在的益处。
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引用次数: 0
Telemedicine in cancer care: lessons from COVID-19 and solutions for Europe. 癌症护理中的远程医疗:2019冠状病毒病的经验教训和欧洲的解决方案。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae206
Anita Gottlob, Tugce Schmitt, Morten Sønderskov Frydensberg, Magdalena Rosińska, Victoria Leclercq, Katharina Habimana

The COVID-19 pandemic challenged healthcare delivery, especially cancer care. Telemedicine emerged as an important tool to reduce disease transmission risks, maintain continuity of care, and improve accessibility. This study explores temporary measures during the pandemic as well as challenges and facilitators for integrating telemedicine into the European healthcare landscape in five case countries, focusing on cancer care. Expert interviews were conducted in five EU countries with diverse health systems: Austria, Belgium, Denmark, Italy, and Poland. A thematic analysis was performed. Themes were further explored related to regulatory changes during COVID-19 as well as barriers and facilitators to telemedicine implementation. COVID-19 accelerated telemedicine uptake and processes (i.e. regulations, reimbursement) in all case countries. Acceptance of telemedicine increased among healthcare professionals and patients. Post-pandemic telemedicine use and acceptance declined to pre-pandemic levels in some countries and was attributed to several factors including preferences for in-person visits. Overall, persistent barriers were identified by all country experts including lack of standardized policies, data privacy concerns, technological infrastructure issues, and digital literacy gaps. Telemedicine was validated by all country experts as an important tool to enhance cancer care access and efficiency and to help maintaining continuity of cancer care during crises. Our findings highlight some overlapping barriers and suggest solutions to overcome these barriers across the selected countries. Recommendations for policymakers are listed, emphasizing the importance of telemedicine services in improving healthcare access, efficiency, and resilience. Future research should incorporate diverse population studies, patient perspectives, cost-effectiveness, and policy impacts.

COVID-19大流行对医疗保健服务,特别是癌症护理提出了挑战。远程医疗已成为减少疾病传播风险、保持护理连续性和改善可及性的重要工具。本研究探讨了大流行期间的临时措施,以及在五个病例国家将远程医疗纳入欧洲医疗保健领域的挑战和促进因素,重点是癌症护理。专家访谈在五个拥有不同卫生系统的欧盟国家进行:奥地利、比利时、丹麦、意大利和波兰。进行了专题分析。会议进一步探讨了2019冠状病毒病期间的监管变化以及远程医疗实施的障碍和促进因素等主题。COVID-19在所有病例国加速了远程医疗的采用和流程(即法规、报销)。医疗保健专业人员和患者对远程医疗的接受程度有所提高。在一些国家,大流行后远程医疗的使用和接受程度下降到大流行前的水平,这可归因于几个因素,包括偏爱亲自就诊。总体而言,所有国家专家都发现了持续存在的障碍,包括缺乏标准化政策、数据隐私问题、技术基础设施问题和数字素养差距。所有国家专家都确认远程医疗是一种重要工具,可提高癌症治疗的可及性和效率,并有助于在危机期间保持癌症治疗的连续性。我们的研究结果强调了一些重叠的障碍,并提出了在选定国家克服这些障碍的解决方案。本文列出了对决策者的建议,强调远程医疗服务在改善医疗服务获取、效率和复原力方面的重要性。未来的研究应纳入不同的人群研究、患者观点、成本效益和政策影响。
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引用次数: 0
Causal association of physical activity with lymphoma risk: a Mendelian randomization analysis. 体育锻炼与淋巴瘤风险的因果关系:孟德尔随机分析。
IF 3.7 3区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Pub Date : 2025-02-01 DOI: 10.1093/eurpub/ckae172
Jin Zhao, Xiaolian Wen, Meijing Zheng, Liping Su, Xiaojing Guo

Controversial relationship of physical activity with lower lymphoma risk has been reported in observational studies. The purpose of this study was to explore the causal correlation of physical activity with lymphoma risk using two-sample Mendelian randomization (MR). Genetic variants associated with physical activity (moderate-to-vigorous physical activity (MVPA), average acceleration physical activity, number of days/week of moderate physical activity 10+ min, and number of days/week of vigorous physical activity 10+ min) and lymphoma [overall lymphoma, Hodgkin lymphoma, mature T/NK-cell lymphomas, diffuse large B-cell lymphoma (DLBCL), and follicular lymphoma] were obtained from published genome-wide association studies (GWAS) and the FinnGen database and used as instrumental variables. Primary results were based on inverse variance-weighted (IVW) analysis and were described as odds ratio (OR) and 95% confidence interval (CI). Higher levels of genetically predicted MVPA (OR = 0.079, 95% CI: 0.021-0.300, P = 0.0002) and number of days/week of vigorous physical activity 10+ min (OR = 0.237, 95% CI: 0.098-0.573, P = 0.0014) were negatively associated with Hodgkin lymphoma risk. There was a weak negative association between high levels of genetically predicted MVPA (OR = 0.114, 95% CI: 0.015-0.856, P = 0.0348) and average acceleration physical activity (OR = 0.830, 95% CI: 0.705-0.976, P = 0.0243) and risk of DLBCL. No causal relationship was observed between physical activity and the risk of overall lymphoma, mature T/NK-cell lymphomas, and follicular lymphoma (P > 0.05). This study supported the causal relationship between higher physical activity levels and lower risks of Hodgkin lymphoma and DLBCL.

在观察性研究中,关于体育锻炼与降低淋巴瘤风险之间的关系存在争议。本研究的目的是采用双样本孟德尔随机法(MR)探讨体力活动与淋巴瘤风险的因果关系。研究人员从已发表的全基因组关联研究(GWAS)和FinnGen数据库中获取了与体力活动(中到剧烈体力活动(MVPA)、平均加速度体力活动、每周10分钟以上的中度体力活动天数和每周10分钟以上的剧烈体力活动天数)和淋巴瘤(总体淋巴瘤、霍奇金淋巴瘤、成熟T/NK细胞淋巴瘤、弥漫大B细胞淋巴瘤(DLBCL)和滤泡淋巴瘤)相关的基因变异,并将其作为工具变量。主要结果基于反方差加权(IVW)分析,并以几率比(OR)和 95% 置信区间(CI)表示。较高水平的遗传预测 MVPA(OR = 0.079,95% CI:0.021-0.300,P = 0.0002)和每周剧烈运动 10 分钟以上的天数(OR = 0.237,95% CI:0.098-0.573,P = 0.0014)与霍奇金淋巴瘤风险呈负相关。基因预测的高水平 MVPA(OR = 0.114,95% CI:0.015-0.856,P = 0.0348)和平均加速体力活动(OR = 0.830,95% CI:0.705-0.976,P = 0.0243)与 DLBCL 风险之间存在微弱的负相关。体力活动与总体淋巴瘤、成熟T/NK细胞淋巴瘤和滤泡淋巴瘤风险之间没有因果关系(P > 0.05)。这项研究支持较高的体力活动水平与较低的霍奇金淋巴瘤和 DLBCL 风险之间的因果关系。
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