Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319447
Mahsa Arab, S. Rashidi, A. Fallah
Glaucoma is an eye disease associated that a worldwide leading cause of irreversible vision loss. This disease is caused by an increase in the pressure in the aqueous humor. Glaucoma can be asymptomatic until a relatively late stage and for this reason, diagnosis is frequently delayed. Early detection of the disease is the key to preventing the progression of the disease and reducing the patient’s vision. This paper investigates an approach for Glaucoma detection using retinal images. In this paper, after the pre-processing level and vessel segmentation of retinal images, the features are extracted by the fractional Fourier transform. Then, the feature’s matrix of 2-D images converted to 1-D images. This paper used the receiver operating characteristic curve for feature selection. Finally, the selected features are classified by different classifiers. We used the high-resolution fundus Glaucoma retina images databases. We achieved an accuracy of 100% with a support vector machine classifier and a linear discriminant analysis classifier. The results indicate using the proposed algorithm, Glaucoma can be detected fast and accurately.
{"title":"Automated Diagnosis of Glaucoma by Using 1-D Retina Images","authors":"Mahsa Arab, S. Rashidi, A. Fallah","doi":"10.1109/ICBME51989.2020.9319447","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319447","url":null,"abstract":"Glaucoma is an eye disease associated that a worldwide leading cause of irreversible vision loss. This disease is caused by an increase in the pressure in the aqueous humor. Glaucoma can be asymptomatic until a relatively late stage and for this reason, diagnosis is frequently delayed. Early detection of the disease is the key to preventing the progression of the disease and reducing the patient’s vision. This paper investigates an approach for Glaucoma detection using retinal images. In this paper, after the pre-processing level and vessel segmentation of retinal images, the features are extracted by the fractional Fourier transform. Then, the feature’s matrix of 2-D images converted to 1-D images. This paper used the receiver operating characteristic curve for feature selection. Finally, the selected features are classified by different classifiers. We used the high-resolution fundus Glaucoma retina images databases. We achieved an accuracy of 100% with a support vector machine classifier and a linear discriminant analysis classifier. The results indicate using the proposed algorithm, Glaucoma can be detected fast and accurately.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128267739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319456
A. Einizade, M. Mozafari, M. Rezaei-Dastjerdehei, Elnaz Aghdaei, A. Mijani, Sepideh Hajipour Sardouie
Attention Deficit Hyperactivity Disorder (ADHD) is a neurological disorder that is the most common childhood disorder. A significant lack of attention and concentration of the child is one of the apparent symptoms of this disorder. Accurate and early diagnosis of this disorder in preschool ages can help the control process and prevent the school problems caused by ADHD. Medical methods for preschool-age children can be problematic and slow down the control process. In these cases, Electroencephalogram (EEG) signals are useful and efficient tools, because of the non-invasiveness, being quite available, and having high temporal resolution. In this paper, we proposed a method to detect ADHD/Normal EEG signals recorded from children in an online and open access dataset. Our proposed method uses the Structural and Functional information of the EEG signals. Structural and functional based features were extracted using Graph Signal Processing (GSP) and Graph Learning (GL) techniques, respectively, which are the generalization of the Classic methods and can consider EEG signals as graph signals on the underlying graph of electrodes. We reached detection accuracies of 79.03% and 82.36% for using GSP and GL based features, respectively. But when we used the fusion of these feature sets, we got a high detection accuracy of 93.47% which shows these feature sets are complementary and consider thorough aspects of EEG signals.
{"title":"Detecting ADHD children based on EEG signals using Graph Signal Processing techniques","authors":"A. Einizade, M. Mozafari, M. Rezaei-Dastjerdehei, Elnaz Aghdaei, A. Mijani, Sepideh Hajipour Sardouie","doi":"10.1109/ICBME51989.2020.9319456","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319456","url":null,"abstract":"Attention Deficit Hyperactivity Disorder (ADHD) is a neurological disorder that is the most common childhood disorder. A significant lack of attention and concentration of the child is one of the apparent symptoms of this disorder. Accurate and early diagnosis of this disorder in preschool ages can help the control process and prevent the school problems caused by ADHD. Medical methods for preschool-age children can be problematic and slow down the control process. In these cases, Electroencephalogram (EEG) signals are useful and efficient tools, because of the non-invasiveness, being quite available, and having high temporal resolution. In this paper, we proposed a method to detect ADHD/Normal EEG signals recorded from children in an online and open access dataset. Our proposed method uses the Structural and Functional information of the EEG signals. Structural and functional based features were extracted using Graph Signal Processing (GSP) and Graph Learning (GL) techniques, respectively, which are the generalization of the Classic methods and can consider EEG signals as graph signals on the underlying graph of electrodes. We reached detection accuracies of 79.03% and 82.36% for using GSP and GL based features, respectively. But when we used the fusion of these feature sets, we got a high detection accuracy of 93.47% which shows these feature sets are complementary and consider thorough aspects of EEG signals.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"214 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122378254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319421
M. Ebrahimkhani, Alireza Abbasi Ghiri, F. Farahmand
Hip joint prostheses generally enjoy intramedullary stems, with multitudinous designs and shapes, for fixation into the femur. There are patients, however, who are not able to use such prostheses, for instance, due to their very narrow medullary canals. This study is designed to investigate the feasibility of using an extramedullary fixation system for hip joint prostheses. The proposed design is based on Dynamic Hip Screw (DHS) which is originally used for the treatment of femoral neck fractures. A voxel-based finite element model of the femur is developed from QCT images of a cadaver. The model is validated by simulating an experimental in-vitro test which investigated the mechanical behavior of proximal femoral bone under compression loading. It is then used to assess the performance of a DHS-based extramedullary fixation system of the hip prosthesis, in comparison with that of a conventional long-stem design. Muscle and joint forces, extracted from a musculoskeletal analysis of the gait cycle, are applied to the model. The resulting stresses in the components of the two designs are analyzed to examine the possibility of their fracture. Also, the strain energy density in the periprosthetic bone is studied to investigate the long-term performance of the designs considering bone remodeling behavior. Results indicate very high stresses in the screws of the DHS-based system, larger than their endurance limit. Also, the DHS-based fixation is found to impose a large amount of stress shielding throughout the fixation site, raising the risk of bone failure or implant loosening due to bone remodeling. It is concluded that the DHS-based design, in its original configuration, might not be appropriate for hip arthroplasty. Suggestions have been given for the design of a practically successful extramedullary hip implant.
{"title":"Finite Element Analysis of A Hip Joint Prosthesis with An Extramedullary Fixation System","authors":"M. Ebrahimkhani, Alireza Abbasi Ghiri, F. Farahmand","doi":"10.1109/ICBME51989.2020.9319421","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319421","url":null,"abstract":"Hip joint prostheses generally enjoy intramedullary stems, with multitudinous designs and shapes, for fixation into the femur. There are patients, however, who are not able to use such prostheses, for instance, due to their very narrow medullary canals. This study is designed to investigate the feasibility of using an extramedullary fixation system for hip joint prostheses. The proposed design is based on Dynamic Hip Screw (DHS) which is originally used for the treatment of femoral neck fractures. A voxel-based finite element model of the femur is developed from QCT images of a cadaver. The model is validated by simulating an experimental in-vitro test which investigated the mechanical behavior of proximal femoral bone under compression loading. It is then used to assess the performance of a DHS-based extramedullary fixation system of the hip prosthesis, in comparison with that of a conventional long-stem design. Muscle and joint forces, extracted from a musculoskeletal analysis of the gait cycle, are applied to the model. The resulting stresses in the components of the two designs are analyzed to examine the possibility of their fracture. Also, the strain energy density in the periprosthetic bone is studied to investigate the long-term performance of the designs considering bone remodeling behavior. Results indicate very high stresses in the screws of the DHS-based system, larger than their endurance limit. Also, the DHS-based fixation is found to impose a large amount of stress shielding throughout the fixation site, raising the risk of bone failure or implant loosening due to bone remodeling. It is concluded that the DHS-based design, in its original configuration, might not be appropriate for hip arthroplasty. Suggestions have been given for the design of a practically successful extramedullary hip implant.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124220025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319327
Milad Mahdinezhad Asiyabi, B. Vahidi
Regenerative medicine allows replacement of damaged tissue due to injury or disease. Vascularization is one of the requirements of the tissue in order to survive and regrowth. One approach to overcome this problem is using microfluidic vessels combined with the drainage channel inside the scaffold. In this study, the scaffold is made of type I collagen with a porosity of 81 percent. The geometry of the vessel follows Murray’s law. The effect of parameters such as vascular hydraulic conductivity, scaffold hydraulic conductivity, drainage channel radius, and perfusion pressure on transmural pressure and shear stress was investigated. Simulations on the vessel with a diameter of 100 μm have shown the maximum interstitial velocity of 50E-9 m/s, maximum interstitial pressure of 1.34E+3 Pa, and minimum transmural pressure of 1.49E+3 Pa. Average shear stress on the wall of the vessel was 10 dyn/cm2. It was noted that decreasing the pressure at the drainage channels outlet, reducing vascular hydraulic conductivity, increasing scaffold hydraulic conductivity, and increasing drainage channel radius will create and maintain a positive transmural pressure in the scaffold.
{"title":"Finite Element Analysis of Artificial Lymphatic Drainage System for a Vascularized Microfluidic Scaffold","authors":"Milad Mahdinezhad Asiyabi, B. Vahidi","doi":"10.1109/ICBME51989.2020.9319327","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319327","url":null,"abstract":"Regenerative medicine allows replacement of damaged tissue due to injury or disease. Vascularization is one of the requirements of the tissue in order to survive and regrowth. One approach to overcome this problem is using microfluidic vessels combined with the drainage channel inside the scaffold. In this study, the scaffold is made of type I collagen with a porosity of 81 percent. The geometry of the vessel follows Murray’s law. The effect of parameters such as vascular hydraulic conductivity, scaffold hydraulic conductivity, drainage channel radius, and perfusion pressure on transmural pressure and shear stress was investigated. Simulations on the vessel with a diameter of 100 μm have shown the maximum interstitial velocity of 50E-9 m/s, maximum interstitial pressure of 1.34E+3 Pa, and minimum transmural pressure of 1.49E+3 Pa. Average shear stress on the wall of the vessel was 10 dyn/cm2. It was noted that decreasing the pressure at the drainage channels outlet, reducing vascular hydraulic conductivity, increasing scaffold hydraulic conductivity, and increasing drainage channel radius will create and maintain a positive transmural pressure in the scaffold.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127714551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319325
S. Kargarnejad, F. Ghalichi, M. Pourgol-Mohammad, A. Garajei
Maxillofacial surgeons face great challenges in the reconstruction of extensive mandibular defects, especially cancer patients. The function of the mandibular reconstruction system and aesthetics are the most important factors that have a significant effect on the quality of life of patients after recovery. In this study, a customized implant was designed and implemented using additive manufacturing method to treat a patient with a lateral mandibular tumor using the CAD/CAM technique. The anatomy of the patient’s mandible and the geometry of the defect site were taken into account while designing the customized implant. The reconstruction system performance was evaluated using COMSOL V5.4, a finite element method. Inclusion criteria include maximum von-Mises stress and deformation implant as well as maximum von-Mises stress and strain in cortical bone around screws. Finite element results showed that the maximum von-Mises stress of the plate was 106 MPa and plate deformation was 54.42 μm. Also, the maximum von-Mises strain and stress of cortical bone around screws were 1940 μm/m and 44 MPa, respectively. After evaluating the biomechanical behavior of the customized implant, it can be concluded that this system has sufficient flexibility and stability and the facial aesthetics will be maintained after recovery. Therefore, the success rate of surgery can be increased by using customized implants in the reconstruction of large mandibular defects while maintaining the aesthetic appearance of the patient.
{"title":"Design and fabrication of mandibular customized implants by CAD/CAM method and 3-D printing","authors":"S. Kargarnejad, F. Ghalichi, M. Pourgol-Mohammad, A. Garajei","doi":"10.1109/ICBME51989.2020.9319325","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319325","url":null,"abstract":"Maxillofacial surgeons face great challenges in the reconstruction of extensive mandibular defects, especially cancer patients. The function of the mandibular reconstruction system and aesthetics are the most important factors that have a significant effect on the quality of life of patients after recovery. In this study, a customized implant was designed and implemented using additive manufacturing method to treat a patient with a lateral mandibular tumor using the CAD/CAM technique. The anatomy of the patient’s mandible and the geometry of the defect site were taken into account while designing the customized implant. The reconstruction system performance was evaluated using COMSOL V5.4, a finite element method. Inclusion criteria include maximum von-Mises stress and deformation implant as well as maximum von-Mises stress and strain in cortical bone around screws. Finite element results showed that the maximum von-Mises stress of the plate was 106 MPa and plate deformation was 54.42 μm. Also, the maximum von-Mises strain and stress of cortical bone around screws were 1940 μm/m and 44 MPa, respectively. After evaluating the biomechanical behavior of the customized implant, it can be concluded that this system has sufficient flexibility and stability and the facial aesthetics will be maintained after recovery. Therefore, the success rate of surgery can be increased by using customized implants in the reconstruction of large mandibular defects while maintaining the aesthetic appearance of the patient.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127995367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319411
Masoud H H Tehrani, M. Soltani, F. M. Kashkooli
The efficacy of intraperitoneal chemotherapy (IPC) can be significantly enhanced by a temperature-sensitive liposomes (TSLs) administration. Magnetic hyperthermia (MHT) has the potential to provide sufficient heat for TSLs to release their contents. For the first time, we used computational modeling to simulate MHT combined with intraperitoneal (IP) delivery of doxorubicin-loaded temperature-sensitive liposomes (TSL-Dox). Results indicate that this combination therapy can improve treatment efficacy. The results also indicate that using large and octahedral MNPs can increase drug penetration by ten folds against normal IPC.
{"title":"Numerical simulation of synergistic interaction of magnetic hyperthermia and intraperitoneal delivery of temperature-sensitive liposomes","authors":"Masoud H H Tehrani, M. Soltani, F. M. Kashkooli","doi":"10.1109/ICBME51989.2020.9319411","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319411","url":null,"abstract":"The efficacy of intraperitoneal chemotherapy (IPC) can be significantly enhanced by a temperature-sensitive liposomes (TSLs) administration. Magnetic hyperthermia (MHT) has the potential to provide sufficient heat for TSLs to release their contents. For the first time, we used computational modeling to simulate MHT combined with intraperitoneal (IP) delivery of doxorubicin-loaded temperature-sensitive liposomes (TSL-Dox). Results indicate that this combination therapy can improve treatment efficacy. The results also indicate that using large and octahedral MNPs can increase drug penetration by ten folds against normal IPC.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"26 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130435759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/icbme51989.2020.9319414
{"title":"ICBME 2020 Program","authors":"","doi":"10.1109/icbme51989.2020.9319414","DOIUrl":"https://doi.org/10.1109/icbme51989.2020.9319414","url":null,"abstract":"","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132522966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319463
Sogol Fathi, Seyed Sepehr Mohseni, Ali Abouei Mehrizi
In recent years, microfluidics has been used widely in various biomedical applications. Due to the multiple advantages derived from capillary microfluidics, such as simplicity, low-cost fabrication, and being fast plus accurate, it has emerged as an alternative to traditional diagnosis assays. Gaining accurate results in the biomedical tests within capillary microfluidic devices requires precise controlling of the fluid flow rate inside the channels, which can be regulated by embedded capillary micropump. Discovering suitable micropump design has always been one of the most technical barriers in the development of capillary microfluidic systems for point-of-care testing. In this study, COMSOL Multiphysics, which is a commercial computational fluid dynamics (CFD) package based on finite element method (FEM), is utilized to perform numerical simulations of the mentioned challenge. The study carried out in five different capillary micropump geometries, which are created by employing a detailed algorithm. Furthermore, an equation based on the outputs of the simulation is calculated, in which the number of pillars for demanded fluid flow rate in the micropump can be determined. The proposed approach in this study assists scientists in designing optimized micropumps for their applications.
{"title":"Flow rate controlling by capillary micropumps in open biomicrofluidic devices","authors":"Sogol Fathi, Seyed Sepehr Mohseni, Ali Abouei Mehrizi","doi":"10.1109/ICBME51989.2020.9319463","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319463","url":null,"abstract":"In recent years, microfluidics has been used widely in various biomedical applications. Due to the multiple advantages derived from capillary microfluidics, such as simplicity, low-cost fabrication, and being fast plus accurate, it has emerged as an alternative to traditional diagnosis assays. Gaining accurate results in the biomedical tests within capillary microfluidic devices requires precise controlling of the fluid flow rate inside the channels, which can be regulated by embedded capillary micropump. Discovering suitable micropump design has always been one of the most technical barriers in the development of capillary microfluidic systems for point-of-care testing. In this study, COMSOL Multiphysics, which is a commercial computational fluid dynamics (CFD) package based on finite element method (FEM), is utilized to perform numerical simulations of the mentioned challenge. The study carried out in five different capillary micropump geometries, which are created by employing a detailed algorithm. Furthermore, an equation based on the outputs of the simulation is calculated, in which the number of pillars for demanded fluid flow rate in the micropump can be determined. The proposed approach in this study assists scientists in designing optimized micropumps for their applications.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128290767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319439
N. Hamedi, Susan Samiei, Mehdi Delrobaei, Ali Khadem
Brain-computer interface (BCI) is defined as the combination of machine and brain signals to control a device or computer to improve the quality of life, e.g., for people with paralysis. In this paper, we focus on people with speech disorders and investigate the capability of electroencephalogram (EEG) signals to discriminate four classes, including the speech imagination of three Persian words corresponding to the English words "rock," "paper," and "scissors," in addition to the resting state. We used the data available from the 3rd Iranian BCI competition (iBCIC2020), acquired from 10 healthy participants in a randomized study. Initially, the mutual information (MI) was used to find the optimum frequency band. Then, features were extracted from the data using the Common Spatial Pattern (CSP) algorithm. Afterward, the most discriminative features were selected using the neighborhood component analysis (NCA). These features were then fed to a meta-classifier based on the stacking ensemble learning. The results show that working on an optimum frequency band will enhance the results compared with the fixed frequency band. It is also worth mentioning that the optimum frequency band is subject dependent; therefore, it is substantial to be selected accurately. Our method achieved an average classification accuracy of 51.90%±2.73 across all participants, which is promising compared with the results of previous studies in the field of imagined speech recognition in subject dependent BCI systems with randomized order of the stimuli.
{"title":"Imagined Speech Decoding From EEG: The Winner of 3rd Iranian BCI Competition (iBCIC2020)","authors":"N. Hamedi, Susan Samiei, Mehdi Delrobaei, Ali Khadem","doi":"10.1109/ICBME51989.2020.9319439","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319439","url":null,"abstract":"Brain-computer interface (BCI) is defined as the combination of machine and brain signals to control a device or computer to improve the quality of life, e.g., for people with paralysis. In this paper, we focus on people with speech disorders and investigate the capability of electroencephalogram (EEG) signals to discriminate four classes, including the speech imagination of three Persian words corresponding to the English words \"rock,\" \"paper,\" and \"scissors,\" in addition to the resting state. We used the data available from the 3rd Iranian BCI competition (iBCIC2020), acquired from 10 healthy participants in a randomized study. Initially, the mutual information (MI) was used to find the optimum frequency band. Then, features were extracted from the data using the Common Spatial Pattern (CSP) algorithm. Afterward, the most discriminative features were selected using the neighborhood component analysis (NCA). These features were then fed to a meta-classifier based on the stacking ensemble learning. The results show that working on an optimum frequency band will enhance the results compared with the fixed frequency band. It is also worth mentioning that the optimum frequency band is subject dependent; therefore, it is substantial to be selected accurately. Our method achieved an average classification accuracy of 51.90%±2.73 across all participants, which is promising compared with the results of previous studies in the field of imagined speech recognition in subject dependent BCI systems with randomized order of the stimuli.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134329936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-26DOI: 10.1109/ICBME51989.2020.9319445
Golara Aghebati, N. Naghavi, Behnaz Gheflati, Shokouhozaman Soleymanifard
Radiotherapy is a common method for cancer treatment. One of the factors that determine the tumor’s malignancy is the presence of cancer stem cells in tumors. These cells not only have a long lifespan but also are capable to proliferate infinitely and have inherent resistance against all therapy methods. The aim of this research is to consider biological processes and their effects on each other in growth and radiotherapy phases by modeling to make the simulation closer to reality. Two main cell’s nutrients, including oxygen and glucose, biological tumor structure, cell cycle phases and telomere length limitation for the mitotic division are considered in the growth phase. Furthermore, 5R factors, cell’s different radiosensitivity in different oxygen levels, and cell’s different radiosensitivity in different cell cycle phases not being allowed to pass checkpoints in cell cycle until the complete repair of sublethal damage caused by radiotherapy, considered in the treatment phase. Then, three radiotherapy patterns were simulated for a heterogeneous tumor having three subpopulations: healthy cells, cancer cells, cancer stem cells. Obtained results are in agreement with the researches in this field.
{"title":"Simulation of Radiotherapy Effects on Destroying Cancer Cells and Cancer Stem Cells","authors":"Golara Aghebati, N. Naghavi, Behnaz Gheflati, Shokouhozaman Soleymanifard","doi":"10.1109/ICBME51989.2020.9319445","DOIUrl":"https://doi.org/10.1109/ICBME51989.2020.9319445","url":null,"abstract":"Radiotherapy is a common method for cancer treatment. One of the factors that determine the tumor’s malignancy is the presence of cancer stem cells in tumors. These cells not only have a long lifespan but also are capable to proliferate infinitely and have inherent resistance against all therapy methods. The aim of this research is to consider biological processes and their effects on each other in growth and radiotherapy phases by modeling to make the simulation closer to reality. Two main cell’s nutrients, including oxygen and glucose, biological tumor structure, cell cycle phases and telomere length limitation for the mitotic division are considered in the growth phase. Furthermore, 5R factors, cell’s different radiosensitivity in different oxygen levels, and cell’s different radiosensitivity in different cell cycle phases not being allowed to pass checkpoints in cell cycle until the complete repair of sublethal damage caused by radiotherapy, considered in the treatment phase. Then, three radiotherapy patterns were simulated for a heterogeneous tumor having three subpopulations: healthy cells, cancer cells, cancer stem cells. Obtained results are in agreement with the researches in this field.","PeriodicalId":120969,"journal":{"name":"2020 27th National and 5th International Iranian Conference on Biomedical Engineering (ICBME)","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125847136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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