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Infographic: Randomized trial of bilateral gene therapy injection for m.11778 G > A MT-ND4 Leber optic neuropathy (REFLECT Trial). 信息图:双侧基因治疗注射治疗m.11778的随机试验g> A MT-ND4 Leber视神经病变(REFLECT试验)。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-02-05 DOI: 10.1038/s41433-026-04266-x
Sam Sherratt-Mayhew, Charles Page, Michael Lowe, Susan P Mollan, Gabriele Berman
{"title":"Infographic: Randomized trial of bilateral gene therapy injection for m.11778 G > A MT-ND4 Leber optic neuropathy (REFLECT Trial).","authors":"Sam Sherratt-Mayhew, Charles Page, Michael Lowe, Susan P Mollan, Gabriele Berman","doi":"10.1038/s41433-026-04266-x","DOIUrl":"https://doi.org/10.1038/s41433-026-04266-x","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging structured EMR data for efficient patient prescreening: a practical approach to reducing screen-failure rates in Light Touch Trial. 利用结构化电子病历数据进行有效的患者预筛查:一种在轻触试验中降低筛查失败率的实用方法。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-02-04 DOI: 10.1038/s41433-026-04267-w
Eleonora Riotto, Francesca Lamanna, Adnan H Khan, Sridevi Thottarath, Hagar Khalid, Swati Chandak, Jessica Bennett, Sarah Hill, Livia Faes, Dun Jack Fu
{"title":"Leveraging structured EMR data for efficient patient prescreening: a practical approach to reducing screen-failure rates in Light Touch Trial.","authors":"Eleonora Riotto, Francesca Lamanna, Adnan H Khan, Sridevi Thottarath, Hagar Khalid, Swati Chandak, Jessica Bennett, Sarah Hill, Livia Faes, Dun Jack Fu","doi":"10.1038/s41433-026-04267-w","DOIUrl":"https://doi.org/10.1038/s41433-026-04267-w","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146117871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure of the Supramid suture-an uninvited disaster. 超级缝合线的暴露——一场不请自来的灾难。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-02-03 DOI: 10.1038/s41433-026-04275-w
Vijayalakshmi A Senthilkumar
{"title":"Exposure of the Supramid suture-an uninvited disaster.","authors":"Vijayalakshmi A Senthilkumar","doi":"10.1038/s41433-026-04275-w","DOIUrl":"https://doi.org/10.1038/s41433-026-04275-w","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infographic: bevacizumab eliminates the angiogenic threat of retinopathy of prematurity (BEAT-ROP study). 信息图:贝伐单抗消除了早产儿视网膜病变的血管生成威胁(BEAT-ROP研究)。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-02-03 DOI: 10.1038/s41433-026-04285-8
Anjali Agrawal, Anil Babanrao Gangwe, Rajesh Awasthi
{"title":"Infographic: bevacizumab eliminates the angiogenic threat of retinopathy of prematurity (BEAT-ROP study).","authors":"Anjali Agrawal, Anil Babanrao Gangwe, Rajesh Awasthi","doi":"10.1038/s41433-026-04285-8","DOIUrl":"https://doi.org/10.1038/s41433-026-04285-8","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infographic: FAME (fluocinolone acetonide for macular edema) trials of ILUVIEN® vitreous sustained-delivery inserts for diabetic macular oedema. 信息图:ILUVIEN®玻璃体持续植入治疗糖尿病性黄斑水肿的FAME(氟西诺酮治疗黄斑水肿)试验。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-02-03 DOI: 10.1038/s41433-026-04271-0
Rivini Singappuli, Poorna Abeysiri, Waheeda Rahman
{"title":"Infographic: FAME (fluocinolone acetonide for macular edema) trials of ILUVIEN® vitreous sustained-delivery inserts for diabetic macular oedema.","authors":"Rivini Singappuli, Poorna Abeysiri, Waheeda Rahman","doi":"10.1038/s41433-026-04271-0","DOIUrl":"https://doi.org/10.1038/s41433-026-04271-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proposed Idiopathic Multiple Retinal Telangiectasias (IMRT). 建议特发性多发性视网膜毛细血管扩张(IMRT)。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-02-03 DOI: 10.1038/s41433-026-04276-9
Guangwei Yu, Qingxu Wang
{"title":"Proposed Idiopathic Multiple Retinal Telangiectasias (IMRT).","authors":"Guangwei Yu, Qingxu Wang","doi":"10.1038/s41433-026-04276-9","DOIUrl":"https://doi.org/10.1038/s41433-026-04276-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical management of aqueous misdirection by endoscopic vitrectomy with Hyaloido-Zonulo-Iridectomy. 内窥镜玻璃体切除术联合玻璃体-虹膜-虹膜切除术后水误导的手术处理。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-02-03 DOI: 10.1038/s41433-026-04265-y
Tan Do, Ha Thi Thu Pham, Andrea Servillo, Tin Aung

Objective: To assess the outcomes of surgical management of aqueous misdirection (AM) by endoscopic pars plana vitrectomy with hyaloido-zonulo-iridectomy.

Materials and methods: In this prospective, longitudinal, noncomparative interventional study, 53 eyes from 46 patients with AM refractory to medical and laser therapy after intraocular surgery were enrolled. All eyes underwent lens removal (if phakic), endoscopic pars plana vitrectomy, and hyaloido-zonulo-iridectomy. Primary outcomes included intraocular pressure (IOP), best-corrected visual acuity (BCVA), anterior chamber depth (ACD), postoperative complications, relapse rate, and composite surgical success. Surgical success was defined as the combination of IOP control and anterior chamber reformation, using two alternative IOP thresholds ( ≥ 6 and ≤18 mmHg, or ≥6 and ≤21 mmHg). Continuous variables were analysed using linear mixed models and expressed as estimated means (est)± standard error.

Results: Mean age was 59.7 ± 12.2 years. The est. IOP decreased from 34.36 ± 0.82 mmHg to 17.47 ± 0.82 mmHg at 12 months (p < 0.001). The est. BCVA improved from 1.50 ± 0.07 to 0.70 ± 0.07 logMAR at 12 months (p < 0.001). The est. ACD increased from 0.70 ± 0.06 to 3.34 ± 0.06 mm (p < 0.001), with complete anterior chamber reformation in all eyes. Postoperative complications occurred in 22 eyes (41.8%), mostly transient and resolved with medical or YAG laser treatment; only one required glaucoma surgery. At 12 months, overall success was 98.1% using the ≤21 mmHg criterion and 75.5% using the ≤18 mmHg criterion. No relapses were observed.

Conclusions: Surgical management using lens removal, endoscopic anterior vitrectomy, and hyaloido-zonulo-iridectomy is a significantly effective and safe treatment for AM.

目的:评估手术的管理水的结果误导(AM)与hyaloido-zonulo-iridectomy内窥镜术后玻璃体切除术。材料和方法:在这项前瞻性、纵向、非对比性介入研究中,纳入了46例眼内手术后药物和激光治疗难治性AM患者的53只眼。所有的眼睛都接受了晶状体摘除(如果有晶状体)、内窥镜玻璃体切除和玻璃体-虹膜带切除术。主要结果包括眼压(IOP)、最佳矫正视力(BCVA)、前房深度(ACD)、术后并发症、复发率和综合手术成功率。手术成功定义为IOP控制和前房改造的结合,使用两个可选的IOP阈值(≥6和≤18 mmHg,或≥6和≤21 mmHg)。连续变量采用线性混合模型进行分析,并以估计均数(est)±标准误差表示。结果:平均年龄59.7±12.2岁。12个月时,眼压由34.36±0.82 mmHg降至17.47±0.82 mmHg (p)。结论:晶状体摘除术、镜下前路玻璃体切除术和玻璃体虹膜切除术是治疗AM的有效且安全的手术治疗方法。
{"title":"Surgical management of aqueous misdirection by endoscopic vitrectomy with Hyaloido-Zonulo-Iridectomy.","authors":"Tan Do, Ha Thi Thu Pham, Andrea Servillo, Tin Aung","doi":"10.1038/s41433-026-04265-y","DOIUrl":"https://doi.org/10.1038/s41433-026-04265-y","url":null,"abstract":"<p><strong>Objective: </strong>To assess the outcomes of surgical management of aqueous misdirection (AM) by endoscopic pars plana vitrectomy with hyaloido-zonulo-iridectomy.</p><p><strong>Materials and methods: </strong>In this prospective, longitudinal, noncomparative interventional study, 53 eyes from 46 patients with AM refractory to medical and laser therapy after intraocular surgery were enrolled. All eyes underwent lens removal (if phakic), endoscopic pars plana vitrectomy, and hyaloido-zonulo-iridectomy. Primary outcomes included intraocular pressure (IOP), best-corrected visual acuity (BCVA), anterior chamber depth (ACD), postoperative complications, relapse rate, and composite surgical success. Surgical success was defined as the combination of IOP control and anterior chamber reformation, using two alternative IOP thresholds ( ≥ 6 and ≤18 mmHg, or ≥6 and ≤21 mmHg). Continuous variables were analysed using linear mixed models and expressed as estimated means (est)± standard error.</p><p><strong>Results: </strong>Mean age was 59.7 ± 12.2 years. The est. IOP decreased from 34.36 ± 0.82 mmHg to 17.47 ± 0.82 mmHg at 12 months (p < 0.001). The est. BCVA improved from 1.50 ± 0.07 to 0.70 ± 0.07 logMAR at 12 months (p < 0.001). The est. ACD increased from 0.70 ± 0.06 to 3.34 ± 0.06 mm (p < 0.001), with complete anterior chamber reformation in all eyes. Postoperative complications occurred in 22 eyes (41.8%), mostly transient and resolved with medical or YAG laser treatment; only one required glaucoma surgery. At 12 months, overall success was 98.1% using the ≤21 mmHg criterion and 75.5% using the ≤18 mmHg criterion. No relapses were observed.</p><p><strong>Conclusions: </strong>Surgical management using lens removal, endoscopic anterior vitrectomy, and hyaloido-zonulo-iridectomy is a significantly effective and safe treatment for AM.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A hypothesis for the characteristic parafoveal toxicity observed in hydroxychloroquine retinopathy. 羟基氯喹视网膜病变的特征性中央凹旁毒性假说。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-01-31 DOI: 10.1038/s41433-026-04270-1
Michele Chan, Nigel Davies
{"title":"A hypothesis for the characteristic parafoveal toxicity observed in hydroxychloroquine retinopathy.","authors":"Michele Chan, Nigel Davies","doi":"10.1038/s41433-026-04270-1","DOIUrl":"https://doi.org/10.1038/s41433-026-04270-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global, regional burden of cataract attributable to Household air pollution from solid fuels, Smoking, high body mass index and high fasting plasma glucose among people aged 55 and older from 1990 to 2021, and forecasts to 2040: analysis from the Global Burden of Disease Study 2021. 1990年至2021年55岁及以上人群因固体燃料、吸烟、高体重指数和高空腹血糖造成的全球和区域白内障负担,以及到2040年的预测:来自《2021年全球疾病负担研究》的分析
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-01-31 DOI: 10.1038/s41433-025-04200-7
Songjia Liu, Ziyi Wang, Zhou Fang, Wei Shen, Yu Gao, Yuan Zhang, Rui Zhang

Background: Cataract remains a significant public health issue, particularly for middle-aged and older adults. This study investigates the Disability-Adjusted Life Years (DALYs) attributed to cataract among people aged 55 and older from 1990 to 2021, providing insights for public health recommendations.

Methods: Using data from the Global Burden of Disease (GBD) database, this study examines the global burden of cataract caused by four risk factors: household air pollution from solid fuels (HAPFSF), smoking, high body-mass index (BMI), and high fasting plasma glucose (FPG) in individuals aged 55 and older. The ARIMA model was used to forecast trends from 2021 to 2040, and data processing was conducted using R and Python software.

Results: The paper analyses the impact of each risk factor, showing how the burden of cataract disease varies across different SDI regions and age groups. It also evaluates the combined effects of these risk factors and assesses their respective contributions to cataract burden in different SDI regions.

Conclusions: The study highlights the need to continue promoting smoking cessation measures and strengthening dietary management to reduce obesity rates. It also suggests replacing solid fuels with clean energy in underdeveloped areas, and enhancing health lifestyle education in developed regions to lower high blood glucose levels, thereby reducing the incidence of cataract.

背景:白内障仍然是一个重要的公共卫生问题,特别是对中老年人。本研究调查了1990年至2021年55岁及以上人群中因白内障导致的残疾调整生命年(DALYs),为公共卫生建议提供见解。方法:利用全球疾病负担(GBD)数据库的数据,本研究调查了55岁及以上人群中由四种危险因素引起的全球白内障负担:固体燃料造成的家庭空气污染(HAPFSF)、吸烟、高体重指数(BMI)和高空腹血糖(FPG)。采用ARIMA模型预测2021 - 2040年的趋势,使用R和Python软件进行数据处理。结果:本文分析了各危险因素的影响,显示了不同SDI地区和年龄组白内障疾病负担的差异。本研究还评估了这些危险因素的综合影响,并评估了它们各自对不同SDI地区白内障负担的贡献。结论:该研究强调了继续推广戒烟措施和加强饮食管理以降低肥胖率的必要性。报告还建议在欠发达地区用清洁能源替代固体燃料,在发达地区加强健康生活方式教育,以降低高血糖水平,从而减少白内障的发病率。
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引用次数: 0
SPECTRUM: early clinical experience from the first global real-world study of aflibercept 8 mg in patients with neovascular age-related macular degeneration. 频谱:来自全球首个阿伯西普8mg治疗新生血管性年龄相关性黄斑变性患者的临床研究。
IF 3.2 3区 医学 Q1 OPHTHALMOLOGY
Eye
Pub Date : 2026-01-30 DOI: 10.1038/s41433-026-04260-3
Clare Bailey, Clemens Lange, Varun Chaudhary, Paolo Lanzetta, Hassiba Oubraham, Martin Kirchner, Tobias Machewitz, Helmut Allmeier, Xin Zhang, Zoran Hasanbasic, Marion R Munk
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引用次数: 0
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Eye
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