Eurosurveillance最新文献

In 2024, based on the European Committee on Antimicrobial Susceptibility Testing breakpoint, we observed a tetracycline resistance prevalence of 62.3% (2,231/3,579) in Neisseria gonorrhoeae isolates from 22 European countries (range: 16.5-100%). Multivariable analysis of correlations between resistance and patients' epidemiological characteristics found tetracycline resistance associated with men who have sex with men (aOR: 1.38; 95% CI: 1.06-1.79). Our results are important when considering measures against transmission of sexually transmitted bacterial infections in Europe, such as in the context of doxycycline post-exposure prophylaxis (doxy-PEP).

Currently, there is concern and uncertainty in the European and North American markets for in vitro diagnostics regarding the regulation of in vitro diagnostic tests. In the European Union, starting from May 2022, the regulation on vitro diagnostic medical devices (IVDR) has replaced the directive on in vitro diagnostic medical devices (IVDD). The IVDR, while written with the good intentions to ensure patient safety and health while supporting innovation and transparency, has resulted in uncertainty, instances of disruption of diagnostic development, and concerns related to pandemic preparedness and response. We here outline the history, current situation and concerns regarding pandemic preparedness in Europe. Finally, we make recommendations that could improve the IVDR while supporting pandemic preparedness.

In 2025, an unprecedented number of autochthonous chikungunya transmission events occurred in mainland France. One of the largest outbreaks took place in Bergerac (south-west France). By 27 October, 100 locally acquired cases were identified. They had symptom onsets between June and October. Our data suggest that door-knocking surveys and vector control measures assisted in slowing the virus spread. Autochthonous outbreaks of mosquito-borne diseases are expected to become more frequent with climate change, so improving outbreak control is crucial.

Trichophyton indotineae is an emerging dermatophyte increasingly detected in the United Kingdom, often with antifungal resistance. We identified 363 cases between January 2017 and August 2025, with 310 cases (85%) since January 2023. Cases were mostly concentrated in major urban centres and most affected individuals were working-age adults, frequently reporting South Asian ethnicity. The importance of international importation vs domestic transmission remains unclear. Implementing enhanced surveillance would help to identify risk factors and transmission routes to focus prevention efforts.

BACKGROUNDSyphilis is increasing among females and heterosexual males (heterosexuals) in Europe and other Western countries. In the Netherlands, there has been an increase in syphilis positivity and diagnoses over the last 10 years. Research on syphilis among heterosexuals and on spatiotemporal syphilis trends in the Netherlands is limited.AIMWe aimed to assess spatiotemporal trends and identify determinants of syphilis among heterosexuals in the Netherlands.METHODSThis study used national surveillance data of all sexual health centres (SHCs) and included consultations among heterosexuals tested for syphilis between 2011 and 2023. Syphilis was defined as an infectious syphilis diagnosis (primary, secondary or early latent). Spatiotemporal trends were assessed using SaTScan, adjusting for demographic and behavioural factors. We performed a multivariate logistic regression to identify demographic and behavioural determinants of syphilis.RESULTSWe analysed 694,698 STI consultations among heterosexuals and identified 686 syphilis diagnoses. We found an increase in syphilis positivity from 0.05% in 2011 to 0.23% in 2023. SaTScan identified two space-time clusters; one in the north (2020-23) and one in the south-west (2019-23) of the Netherlands. Living with HIV (adjusted odds ratio (aOR): 17.48; 95% CI: 11.75-25.08) and having symptoms (aOR: 2.73; 95% CI: 2.34-3.20) were most strongly associated with syphilis.CONCLUSIONWe found an increasing trend of syphilis among heterosexuals diagnosed at SHCs in the Netherlands. Syphilis was found in all regions. Since living with HIV was the strongest risk factor for syphilis, increased testing among heterosexuals living with HIV, both at SHCs and HIV treatment clinics, is recommended.

Between July and October 2025, among the total 117 influenza A(H1N1)pdm09 strains characterised in Catalonia, 20% to 100% per week were carrying the NA:S247N substitution. The mutation, conferring reduced susceptibility to oseltamivir, was phenotypically confirmed (IC₅₀ between 0.82 and 1.63 nM, compared to median IC₅₀ of 0.3 nM for susceptible strains). An increased proportion of S247N variants was also observed in sequence data (10,944 sequences) from other parts of Spain and five of 35 submitting countries across Europe.