Evidence-based dentistry最新文献

{"title":"Unpacking the evidence: a deeper look at foraminal enlargement and postoperative pain outcomes","authors":"Arash Shahravan","doi":"10.1038/s41432-025-01194-9","DOIUrl":"10.1038/s41432-025-01194-9","url":null,"abstract":"Fatima S, Andrabi S M, Alam S et al. Effect of foraminal enlargement on postoperative pain in primary endodontic treatment: a systematic review and meta-analysis. J Endod 2025; 51: 1536–1548. The purpose of this systematic review and meta-analysis was to investigate how foraminal enlargement (FE) affects postoperative pain following primary endodontic treatment. A systematic literature search was conducted across four major databases— PubMed/MEDLINE, Scopus, Web of Science, and the Cochrane Library—to identify randomized controlled trials evaluating the impact of foraminal enlargement (FE) versus non-foraminal enlargement (NFE) on postoperative pain. The risk of bias in the included studies was evaluated using the Revised Cochrane Risk-of-Bias Tool for Randomized Trials. A meta-analysis was planned to quantitatively assess the impact of foraminal enlargement (FE) on pain during the first 7 days following treatment Eight randomized controlled trials (RCTs) involving a total of 802 participants met the inclusion criteria. The risk-of-bias assessment indicated that two studies were at high risk, four raised some concerns, and two were at low risk. Meta-analysis demonstrated that foraminal enlargement (FE) was associated with significantly greater postoperative pain compared to non-foraminal enlargement (NFE) at 12 h (SMD = 0.79, 95% CI [0.30, 1.28], p = 0.002; I² = 28%), 24 hours (SMD = 0.74, 95% CI [0.12, 1.36], p = 0.02; I² = 89%), and 48 h (SMD = 2.90, 95% CI [0.23, 5.57], p = 0.03; I² = 98%). This meta-analysis indicates that postoperative pain is markedly elevated following foraminal enlargement (FE) compared to non-foraminal enlargement (NFE) during the initial 48-hour period, although such pain is generally mild to moderate and transient. Future investigations are warranted to delineate the impact of FE on essential clinical outcomes, including long-term success rates, and to determine whether its prospective advantages outweigh the attendant short-term increase in discomfort.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 4","pages":"166-167"},"PeriodicalIF":2.3,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145631507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Braces meet bots: straight teeth and straight answers?","authors":"Soumya Narayani Thirumoorthy, Saumiya Gopal, Darshit Shah","doi":"10.1038/s41432-025-01191-y","DOIUrl":"10.1038/s41432-025-01191-y","url":null,"abstract":"Santonocito S, Cicciù M, Ronsivalle V. Evaluation of the impact of AI-based chatbot on orthodontic patient education: a preliminary randomized controlled trial. Clin Oral Investig 2025; 29:278. Randomized controlled trial (RCT). A sample of 100 patients was enrolled in the study between June 2023 and August 2024. Participants were randomly allocated into two intervention groups of 50 each, using a computer-generated sequence to maintain a 1:1 ratio. The Chatbot group received oral hygiene (OH) and orthodontic treatment guidance via a chatbot accessed through a QR code, while the control group was given standard educational material by means of information leaflets compiled by the leading scientific societies in orthodontics. Each main group was further divided into two subgroups: Leaflet-fixed therapy (LF, n = 27), Leaflet-aligner (LA, n = 23), Chatbot-fixed therapy (CF, n = 24), and Chatbot-aligner (CA, n = 26). The chatbot was built on the open-source Botpress platform and was refined using expert-reviewed training materials. When the participant opens the chatbot application, the interface displays a menu containing 4 questions, with the 3rd question focusing on home oral hygiene procedures. The evaluation included a clinical examination at baseline (T0) and after 5 weeks of starting orthodontic treatment (T1), along with a questionnaire at T1 assessing participants’ oral hygiene knowledge and compliance. Modified gingival index (MGI) and plaque index (PI) were used for clinical examination of oral hygiene. The questionnaire comprised four domains: Knowledge Evaluation (KE_S), Understanding Scale (US_S), Compliance and Adherence Scale (CAAS_S), and Satisfaction Scale (SS_S). It employed a 5-point Likert scale, with scores ranging from 0 (strongly negative) to 4 (strongly positive), with intermediate values representing negative, neutral, and positive responses. MGI and PI showed a statistically significant increase from T0 to T1 in both groups. While comparing the change in MGI from the start of treatment between the groups, a statistically significant increase was found in the control group than the chatbot group. Further analysis reported statistically lower increase in MGI in the CF and CA groups as compared to the LF and LA subgroups. There were no differences between the control and chatbot groups with respect to questionnaire section scores. The study concluded that the use of an AI-based chatbot positively influences patient compliance with oral hygiene maneuvers. Furthermore, it could not be established whether the AI-based chatbot enhanced the patient’s knowledge, understanding, and satisfaction with the information received compared to the information leaflets.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 4","pages":"162-163"},"PeriodicalIF":2.3,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145603350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of mouth rinses on caries prevention and arrest: an umbrella review","authors":"Kyriaki Seremidi, Sotiria Davidopoulou, Eleftherios Kaklamanos, Christos Rahiotis, Sotiria Gizani, Panagiotis Koromantzos, Yiorgos Bobetsis, Panagiotis Karakostas, Chrysoula Giota, Konstantinos Papadimitriou, Danae Anastasia Apatzidou, William Papaioannou, Sotiris Kalfas","doi":"10.1038/s41432-025-01188-7","DOIUrl":"10.1038/s41432-025-01188-7","url":null,"abstract":"Among various fluoride delivery methods, such as toothpaste, varnishes, and water fluoridation, mouthrinses have gained attention for their versatility, ease of use, and potential to complement other preventive strategies. The aim was to evaluate the effectiveness of mouthrinses in preventing and arresting caries by synthesizing data from existing systematic reviews. Five electronic databases, named PubMed, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, Web of Science and Scopus, were searched to identify systematic reviews that assessed the effect of mouthrinses containing chemical, herbal, or natural agents in comparison to standard oral care, placebo, water, or saline in the development or arrest of crown or root caries. Eligible reviews were selected, and data were extracted and assessed for bias. Three systematic reviews with meta-analysis and four without were included, with a total of eighty-three initial studies (moderate overlap). Supervised regular use of fluoride mouthrinse can reduce coronal and root caries initiation and progression in permanent teeth for an observational period of 6 months to 4 years. The only significant effect was in favor of the fluoride mouthrinse for crown caries at 36 months and root caries at 48 months follow-up time. Mouthrinses effectively reduce the occurrence of crown caries in moderate- and high-risk patients, as well as root caries in older adults. However, their anticaries benefit in populations with additional fluoride exposure remains uncertain. Given the great variability in the design, inclusion criteria set and conduct of the eligible systematic reviews, it is impossible to reach specific conclusions concerning the efficacy of any single product. However, it seems that fluoride mouthrinses are effective in preventing and/or arresting dental caries in moderate and high caries risk patients and may reduce initiation of root caries in older individuals.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 4","pages":"179-179"},"PeriodicalIF":2.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145573470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretable machine learning modeling of treatment outcomes for silver and fluoride therapy in early childhood caries","authors":"Mojtaba Mehrabanian, Shahab Kavousinejad, Ebrahim Dastouri","doi":"10.1038/s41432-025-01195-8","DOIUrl":"10.1038/s41432-025-01195-8","url":null,"abstract":"Wu Y, Jia M, Fang Y, Duangthip D, Chu C H, Gao S S. Use machine learning to predict the treatment outcome of early childhood caries. BMC Oral Health 2025; 25: 389. This was a retrospective secondary analysis of data from a randomized controlled trial published in 2020. No new participants or patient involvement were included. This study used the available data from 880 children, contributing 4157 carious tooth surfaces assessed at 30 months. These data were drawn from an original community-based RCT in Hong Kong (baseline N = 1070) that evaluated fluoride and silver interventions for arresting ECC. Six algorithms were used and compared, including logistic regression (LR), naive Bayes (NB), support-vector machine (SVM), decision tree (DT), random forest (RF), and XGBoost. A surface-level 70:30 train: test split was used. SMOTE was applied to address class imbalance. Models were tuned and evaluated using 1000 bootstrap resamples. Performance metrics were reported as accuracy, recall, precision, F1 score, AUROC, and Brier score. Model interpretability was explored through SHAP analysis to rank variable importance and visualize feature effects. All models achieved acceptable discrimination. Metrics ranged as follows: accuracy 0.674–0.740; recall 0.731–0.809; precision 0.762–0.802; F1 0.741–0.804; AUROC 0.771–0.859 (RF and XGBoost ≈ 0.86); Brier 0.134–0.227. SHAP interpretation indicated that tooth and surface location of caries, newly developed dmfs, baseline dmfs, caregiver-assisted brushing, and visible plaque index contributed most to the model’s predictions, while the fluoride and silver intervention ranked mid-to-low in importance. The original study, however, highlighted tooth and surface location of caries, newly developed dmfs, and daily snack intake as key effect modifiers influencing caries-arrest outcomes. Machine learning models, specifically ensemble tree-based methods, can discriminate which surfaces arrest by 30 months using multidomain inputs spanning clinical, behavioral, and socioeconomic features. However, participant-level splitting was not performed, allowing potential clustering leakage. External validation and detailed calibration analyses were also lacking. These methodological constraints likely inflated model performance and currently limit its generalizability and readiness for clinical implementation.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 4","pages":"168-169"},"PeriodicalIF":2.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is silver diamine fluoride more effective than sodium fluoride varnish at preventing caries in upper anterior primary teeth?","authors":"Laura Timms, Zoe Marshman","doi":"10.1038/s41432-025-01192-x","DOIUrl":"10.1038/s41432-025-01192-x","url":null,"abstract":"Zheng F M, Yan I G, Duangthip D, Lo E C M, Gao S S, Chu C H. Randomized clinical trial on caries prevention of silver diamine fluoride. J Dent Res 2025; https://doi.org/10.1177/00220345251363837 . This randomised controlled trial sought to compare the effectiveness of silver diamine fluoride (SDF) to sodium fluoride varnish (NaF) for the prevention of caries in anterior primary teeth for young children. The inclusion criteria were children aged 3–4 years of age. Children were excluded if they had co-operative challenges or were on long-term medications. Children with active caries were included, lesions were considered active if they were soft on probing. The setting was kindergartens in Hong Kong. The children received either 38% SDF or 5% NaF applied to their six upper anterior primary teeth at six-monthly intervals. The primary outcome measure was the mean number of new carious surfaces per child at 30 months follow-up. Intention-to-treat analysis was used with the Mann-Whitney U test applied for the analysis of the primary outcome. Overall, 730 children were randomised, 621 (85%) were followed up and analysed at the 30 months end point for the presence of new carious surfaces (dmfs). Not all children seen at baseline were analysed, however of those that were their caries experience was similar with a mean dmfs of 0.47 ± 1.35 for the SDF group and 0.48 ± 1.53 for the NaF group. At 30 months, there were less new lesions for those in the SDF group (0.35 ± 1.09), than the NaF group (0.54 ± 1.50) (p = 0.048). The authors concluded that SDF was more effective than NaF in preventing new carious surfaces at 30 months for anterior caries in primary teeth of young children.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 4","pages":"170-171"},"PeriodicalIF":2.3,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41432-025-01192-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145563378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regenerative approaches in dentistry: an evidence-based perspective.","authors":"Rajpal Tattar","doi":"10.1038/s41432-025-01189-6","DOIUrl":"https://doi.org/10.1038/s41432-025-01189-6","url":null,"abstract":"","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145530574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping risk of bias criteria in systematic reviews of in vitro endodontic studies: an umbrella review","authors":"Rafaella Rodrigues da Gama, Lucas Peixoto de Araújo, Evandro Piva, Leandro Perello Duro, Adriana Fernandes da Silva, Wellington Luiz de Oliveira da Rosa","doi":"10.1038/s41432-025-01186-9","DOIUrl":"10.1038/s41432-025-01186-9","url":null,"abstract":"The risk of bias (RoB) assessment is a critical aspect of systematic reviews, yet a lack of standardization in RoB criteria persists in the endodontic literature. This study aimed to evaluate the RoB tools used in systematic reviews (SRs) of in vitro endodontic studies to synthesize the most commonly employed criteria. A comprehensive search of five databases (PubMed, Embase, Web of Science, Scopus, and Cochrane Library) was conducted, identifying SRs with RoB evaluation. Data were extracted independently by two reviewers, focusing on the criteria used for RoB assessment. All SRs were categorized by main objective and the evaluation test. The study protocol was registered in the Open Science Framework ( https://osf.io/azd8u/ ). Of the 10,409 records initially identified, 142 systematic reviews (SRs) published between January 2018 and September 2024 met the inclusion criteria. These SRs employed 36 distinct RoB criteria, with the most common being blinding (40.9%), sample size (34.5%), adequate statistical analysis (31%), randomization (30.3%), and standardized sample preparation and handling (21.8%). Inconsistencies in the application of RoB criteria were evident, with many SRs employing tools adapted from clinical studies that were not fully suitable for the unique methodological requirements of in vitro research. Although some SRs attempted to adapt criteria from other studies, these adaptations often fell short of addressing the specific needs of in vitro studies. The absence of standardized tools compromises the reliability of current SRs and limits their comparability with future research. The observed inconsistencies in RoB assessments across SRs of in vitro endodontic studies highlight the critical need for a standardized tool specifically designed for this context. Such a tool should account for the methodological nuances of in vitro research, including the relevance of criteria like blinding and sample size calculation, to enhance the reliability, reproducibility, and overall relevance of future SRs.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 4","pages":"179-180"},"PeriodicalIF":2.3,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145502629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bond strength of flowable dental composites in the cementation of indirect restorations: a systematic review and meta-analysis","authors":"Baharan Ranjbar Omidi, Soolmaz Heidari, Armin Izadpanah","doi":"10.1038/s41432-025-01187-8","DOIUrl":"10.1038/s41432-025-01187-8","url":null,"abstract":"This systematic review evaluated experimental evidence on how incorporating flowable dental composites affects the bond strength of dental cementation. This systematic review, following PRISMA guidelines, assessed in vitro studies (2003–2025) on the effect of flowable composites on cementation bond strength using a comprehensive database search, QUIN Tool for bias assessment, Begg’s and Egger’s tests for publication bias, and random-effects meta-analysis with SMD and I² statistics. This systematic review included eight in vitro studies published between 2003 and 2025. The meta-analysis found no statistically significant differences among the various bond strength test methods. Although the shear bond strength (SBS) test demonstrated a significant effect, the high heterogeneity among studies limits the reliability of this result. Etchable ceramics showed favourable effect sizes, but again, the high heterogeneity reduces the certainty of this finding. No significant difference was observed between self-etch and self-adhesive resin cements; however, self-etch resin cements tended to perform better in terms of bond strength. Nevertheless, the substantial heterogeneity in both adhesive groups indicates notable variability across studies. For the dual-cured group, a statistically significant standardized mean difference was observed, suggesting a positive effect of the dual-cured luting cement compared to the light-cured luting cement. Flowable dental composites generally perform comparably to conventional resin cements, with dual-cured and self-etch resin cements showing a tendency toward improved bond strength. However, variability across studies limits the certainty of these results. Further standardized in vitro studies are needed to confirm these findings and guide clinical application.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 4","pages":"178-179"},"PeriodicalIF":2.3,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145471024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibre or facade? Do fibre reinforced composites really hold up in Class II restorations?","authors":"Celine Raseekaanthan, Pirashani Umassudan","doi":"10.1038/s41432-025-01184-x","DOIUrl":"10.1038/s41432-025-01184-x","url":null,"abstract":"Mohamed M H, Abouauf E A, Mosallam R S. Clinical performance of class II MOD fiber reinforced resin composite restorations: an 18-month randomized controlled clinical trial. BMC Oral Health 2025;25: 159. https://doi.org/10.1186/s12903-025-05521-5 . A double blinded 18-month randomised controlled trial was carried out to compare the clinical performance of fibre reinforced resin composites compared to conventional nanohybrid resin composites in restoring Class II MOD cavities. Participants were allocated to one of three groups: Group 1 with short glass fibre reinforced resin composite, Group 2 with polyethylene fibre reinforced resin composite and Group 3 with conventional nanohybrid resin composite. A principal investigator carried out the restorative procedures for all participants. Participants in the study were enrolled from the educational clinic in Cairo University, Egypt. A total of 45 participants with a mean age of 32.3 ± 7.3 years were included. All participants had class II MOD carious lesions in vital posterior teeth with ICDAS scores of 3,4 or 5. Additionally only those with good oral hygiene, a healthy periodontal status and normal occlusion were included. The study excluded pregnant patients, as well as those with systemic disease or evidence of parafunctional habits. Patients with hypersensitivity, allergy to materials used, secondary caries or delayed response to sensibility testing were also excluded. Outcomes were assessed by two examiners at the baseline and at the following time intervals: 3, 6, 12, 18 months using Modified USPHS criteria. The primary outcome assessed was marginal adaptation, followed by gross fracture, marginal discolouration, colour match and recurrent caries. The clinical significance was determined based on relative risk. The chi-Square test compared between groups with significance set at P ≤ 0.016, and Cochran’s Q test compared within groups with significance at P ≤ 0.005, both adjusted using Bonferroni correction. The study was conducted with a 95% confidence level and an 80% statistical power. The study had a 97.7% retention rate with all but one patient successfully completing the 18 month follow up period. Colour match was the only outcome that showed a statistically significant difference between the groups, with short glass fibre reinforced restorations displaying some colour discrepancies. Other outcomes such as marginal adaptation, marginal discoloration, recurrent caries and gross fracture showed no significant differences between groups. Age, gender and tooth distribution also showed no significant statistical differences. The clinical performance of fibre-reinforced resin composite restorations are similar and comparable to nanohybrid composite restorations over an 18-month duration. Short glass fibre-reinforced restorations displayed variations in colour match, indicating that aesthetic outcomes should be carefully considered.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 3","pages":"144-145"},"PeriodicalIF":2.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"We still need to bridge the gap","authors":"Mona Nasser","doi":"10.1038/s41432-025-01183-y","DOIUrl":"10.1038/s41432-025-01183-y","url":null,"abstract":"","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 3","pages":"121-122"},"PeriodicalIF":2.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41432-025-01183-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}