Pub Date : 2025-05-16DOI: 10.1038/s41432-025-01159-y
Neeraj Gugnani, Shalini Gugnani
Van Doornik SP, van Kammen L, Ren Y, Manton D J, Kuijpers-Jagtman A M. Effect of a plaque-identifying toothpaste on plaque amount in 12–16-year-olds with fixed orthodontic appliances: a randomised, double-blind, controlled clinical trial. Orthod Craniofac Res 2025; https://doi.org/10.1111/ocr.12904 . The study aimed to evaluate the effectiveness of a plaque-identifying toothpaste in improving plaque removal among adolescents undergoing fixed orthodontic treatment. This was a double-blind, parallel-group RCT with active-control, having two groups with equal allocation ratio. Participants were healthy adolescents aged 12–16 years with fixed orthodontic appliances in both arches for a minimum of three months. Another inclusion criterion was presence of permanent teeth (canine to canine), while exclusion criteria included toothpaste allergies, syndromic conditions, craniofacial abnormalities, and participants from the same household. A total of 77 participants were included, and were randomized into the intervention (plaque-identifying toothpaste) and control groups (conventional toothpaste). The intervention group was provided with a toothpaste containing disclosing dyes (Mara Expert) intended for plaque-identification, while the control group was provided with a standard toothpaste (Colgate Fresh Gel). The patients were instructed to use the toothpastes for a period of 4–7 weeks, following which assessments were done. The primary outcome included evaluation of changes in the plaque accumulation from baseline to follow-up, as assessed by determining change in fluorescence, which was evaluated using Quantitative Light-Induced Fluorescence (QLF). Secondary outcomes were assessed through a structured questionnaire focusing on user experience and self-perceived oral hygiene behaviours. Patients in both groups showed plaque reduction over time. But the difference observed in plaque reduction between the two groups was not found to be statistically significant (F = 0.211; p = 0.647). However, in the questionnaire, users of the plaque-disclosing toothpaste felt ‘they are removing more plaque with their new toothpaste’ (p = 0.018), and some participants found its colour to be unappealing (p = 0.028). Overall compliance was good, and no adverse effects were reported. Plaque-identifying toothpaste did not demonstrate a superior clinical reduction in plaque levels compared to the control, though increased awareness of plaque removal was observed in the intervention group.
Van Doornik SP, Van Kammen L, Ren Y, Manton D J, Kuijpers-Jagtman A M.牙菌斑识别牙膏对12-16岁固定正畸矫治器牙菌斑数量的影响：一项随机、双盲、对照临床试验。颅面矫形器2025；https://doi.org/10.1111/ocr.12904 .设计：本研究旨在评估牙菌斑识别牙膏在接受固定正畸治疗的青少年中促进牙菌斑清除的有效性。这是一项双盲、平行组、主动对照的随机对照试验，两组分配比例相等。病例选择：参与者是12-16岁的健康青少年，在双牙弓固定正畸矫治器至少三个月。另一个纳入标准是存在恒牙（犬对犬），而排除标准包括牙膏过敏，综合征条件，颅面异常和来自同一家庭的参与者。共纳入77名参与者，并随机分为干预组（牙菌斑识别牙膏）和对照组（传统牙膏）。数据分析：干预组使用含有揭露染料的牙膏（玛拉专家）用于牙菌斑识别，对照组使用标准牙膏（高露洁新鲜凝胶）。指导患者使用牙膏4-7周，随后进行评估。主要结果包括评估从基线到随访期间斑块积累的变化，通过测定荧光变化来评估，荧光变化使用定量光诱导荧光（QLF）进行评估。次要结果通过关注用户体验和自我感知口腔卫生行为的结构化问卷进行评估。结果：两组患者的斑块均随时间减少。但两组在斑块减少方面的差异无统计学意义(F = 0.211；p = 0.647)。然而，在调查问卷中，使用暴露牙菌斑牙膏的人认为“他们用新牙膏可以清除更多的牙菌斑”（p = 0.018），一些参与者认为新牙膏的颜色不吸引人（p = 0.028）。总体依从性良好，无不良反应报告。结论：与对照组相比，牙菌斑识别牙膏在减少牙菌斑水平方面并没有表现出卓越的临床效果，尽管在干预组中观察到牙菌斑清除意识的增强。
{"title":"Can plaque-identifying toothpastes inspire better oral hygiene among orthodontic patients?","authors":"Neeraj Gugnani, Shalini Gugnani","doi":"10.1038/s41432-025-01159-y","DOIUrl":"10.1038/s41432-025-01159-y","url":null,"abstract":"Van Doornik SP, van Kammen L, Ren Y, Manton D J, Kuijpers-Jagtman A M. Effect of a plaque-identifying toothpaste on plaque amount in 12–16-year-olds with fixed orthodontic appliances: a randomised, double-blind, controlled clinical trial. Orthod Craniofac Res 2025; https://doi.org/10.1111/ocr.12904 . The study aimed to evaluate the effectiveness of a plaque-identifying toothpaste in improving plaque removal among adolescents undergoing fixed orthodontic treatment. This was a double-blind, parallel-group RCT with active-control, having two groups with equal allocation ratio. Participants were healthy adolescents aged 12–16 years with fixed orthodontic appliances in both arches for a minimum of three months. Another inclusion criterion was presence of permanent teeth (canine to canine), while exclusion criteria included toothpaste allergies, syndromic conditions, craniofacial abnormalities, and participants from the same household. A total of 77 participants were included, and were randomized into the intervention (plaque-identifying toothpaste) and control groups (conventional toothpaste). The intervention group was provided with a toothpaste containing disclosing dyes (Mara Expert) intended for plaque-identification, while the control group was provided with a standard toothpaste (Colgate Fresh Gel). The patients were instructed to use the toothpastes for a period of 4–7 weeks, following which assessments were done. The primary outcome included evaluation of changes in the plaque accumulation from baseline to follow-up, as assessed by determining change in fluorescence, which was evaluated using Quantitative Light-Induced Fluorescence (QLF). Secondary outcomes were assessed through a structured questionnaire focusing on user experience and self-perceived oral hygiene behaviours. Patients in both groups showed plaque reduction over time. But the difference observed in plaque reduction between the two groups was not found to be statistically significant (F = 0.211; p = 0.647). However, in the questionnaire, users of the plaque-disclosing toothpaste felt ‘they are removing more plaque with their new toothpaste’ (p = 0.018), and some participants found its colour to be unappealing (p = 0.028). Overall compliance was good, and no adverse effects were reported. Plaque-identifying toothpaste did not demonstrate a superior clinical reduction in plaque levels compared to the control, though increased awareness of plaque removal was observed in the intervention group.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 2","pages":"101-102"},"PeriodicalIF":2.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-13DOI: 10.1038/s41432-025-01152-5
Mohammad Zakaria Nassani
Meijer H J A, Slagter K W, Gareb B, Hentenaar D F M, Vissink A, Raghoebar G M. Immediate single-tooth implant placement in bony defect sites: a 10-year randomized controlled trial. J Periodontol 2025; 96: 151–163. This single-center, 10-year randomized controlled trial (RCT) was conducted at the University Medical Center Groningen (UMCG), the Netherlands, to compare immediate and delayed implant placement in patients with a failing tooth in the aesthetic region and a buccal bony defect of ≥5 mm. Forty patients were randomly assigned to either the Immediate Group (immediate implant placement with bone grafting and delayed provisionalization) or the Delayed Group (ridge preservation followed by delayed implant placement and provisionalization). Cone beam computed tomography (CBCT) was used preoperatively to assess palatal bone availability. Surgical procedures were standardized and performed by a single experienced oral and maxillofacial surgeon, while prosthetic procedures were completed by a single prosthodontist. Patients were followed up for 10 years to assess marginal bone levels (MBL), buccal bone thickness (BBT), soft tissue changes, aesthetic outcomes, patient satisfaction, and biological and technical complications. Patients with a compromised tooth in the maxillary aesthetic zone and a buccal bone defect of ≥5 mm following extraction were included. Patients were excluded if they met any of the following criteria: poor oral hygiene, inadequate mesio-distal space for implant placement, presence of periodontal disease, smoking, an American Society of Anesthesiologists (ASA) score of ≥II, or a vertical bony defect of less than 5 mm in the labial socket wall after tooth extraction. The primary outcome, change in marginal bone level, was analyzed using a per-protocol strategy. Normally distributed data were summarized using means and confidence intervals and compared with the independent samples t-test, while non-normally distributed data were described using medians and interquartile ranges and compared using the Mann-Whitney U test. To check the robustness of the findings, sensitivity analyses were conducted, including an intention-to-treat analysis. For outcomes with repeated measurements, multivariable linear mixed-effect models were utilized to examine differences between the treatment groups over time. All statistical analyses were performed using the R software (version 4.0.5), and a p-value less than 0.05 was the criterion for statistical significance. After 10 years, the mean marginal bone level change was −0.71 ± 0.59 mm in the Immediate Group and −0.36 ± 0.39 mm in the Delayed Group, with no statistically significant difference between them (p = 0.063). Secondary outcomes showed no significant variations between the two groups. Immediate implant placement with bone augmentation in postextraction sockets with buccal bony defects ≥5 mm yielded similar long-term outcomes to delayed implant placement after ridge preservation in the aesth
mejer H J A, Slagter K W, Gareb B, Hentenaar D F M, Vissink A, Raghoebar G .骨缺损即刻单牙种植的10年随机对照试验。牙周病杂志；96: 151 - 163。设计：这项单中心、10年随机对照试验（RCT）在荷兰格罗宁根大学医学中心（UMCG）进行，比较美学区缺牙和颊骨缺损≥5mm患者的即刻和延迟种植体置放。40例患者被随机分配到立即组（立即种植体植入植骨并延迟固定）或延迟组（保留脊骨后延迟种植体放置和固定）。术前使用锥形束计算机断层扫描（CBCT）评估腭骨可用性。手术程序标准化，由一名经验丰富的口腔颌面外科医生执行，而修复程序由一名修复牙医完成。患者随访10年，评估边缘骨水平（MBL）、颊骨厚度（BBT）、软组织变化、美学结果、患者满意度以及生物和技术并发症。病例选择：包括上颌美观区受损牙齿和拔牙后颊骨缺损≥5mm的患者。符合以下任何条件的患者均被排除：口腔卫生差，种植体中-远端间隙不足，存在牙周病，吸烟，美国麻醉医师协会（ASA）评分≥II，或拔牙后唇槽壁垂直骨缺损小于5mm。数据分析：主要结果，边缘骨水平的变化，使用每协议策略进行分析。正态分布的数据使用均值和置信区间进行汇总，并与独立样本t检验进行比较，而非正态分布的数据使用中位数和四分位数范围进行描述，并使用Mann-Whitney U检验进行比较。为了检查结果的稳健性，进行了敏感性分析，包括意向治疗分析。对于重复测量的结果，使用多变量线性混合效应模型来检查治疗组之间随时间的差异。所有统计分析均使用R软件（4.0.5版）进行，p值小于0.05为统计学显著性标准。结果：术后10年，即刻组平均骨缘变化为-0.71±0.59 mm，延迟组为-0.36±0.39 mm，差异无统计学意义（p = 0.063）。次要结果显示两组间无显著差异。结论：在拔牙后颊骨缺损≥5mm的牙槽即刻植入骨增强体与在美观区保留牙脊后延迟植入相似，在10年内在骨稳定性、临床表现、美观性或患者满意度方面没有显著差异。
{"title":"Immediate versus delayed single-tooth implant placement in bony defect sockets in the aesthetic zone: Is an intact buccal wall necessary?","authors":"Mohammad Zakaria Nassani","doi":"10.1038/s41432-025-01152-5","DOIUrl":"10.1038/s41432-025-01152-5","url":null,"abstract":"Meijer H J A, Slagter K W, Gareb B, Hentenaar D F M, Vissink A, Raghoebar G M. Immediate single-tooth implant placement in bony defect sites: a 10-year randomized controlled trial. J Periodontol 2025; 96: 151–163. This single-center, 10-year randomized controlled trial (RCT) was conducted at the University Medical Center Groningen (UMCG), the Netherlands, to compare immediate and delayed implant placement in patients with a failing tooth in the aesthetic region and a buccal bony defect of ≥5 mm. Forty patients were randomly assigned to either the Immediate Group (immediate implant placement with bone grafting and delayed provisionalization) or the Delayed Group (ridge preservation followed by delayed implant placement and provisionalization). Cone beam computed tomography (CBCT) was used preoperatively to assess palatal bone availability. Surgical procedures were standardized and performed by a single experienced oral and maxillofacial surgeon, while prosthetic procedures were completed by a single prosthodontist. Patients were followed up for 10 years to assess marginal bone levels (MBL), buccal bone thickness (BBT), soft tissue changes, aesthetic outcomes, patient satisfaction, and biological and technical complications. Patients with a compromised tooth in the maxillary aesthetic zone and a buccal bone defect of ≥5 mm following extraction were included. Patients were excluded if they met any of the following criteria: poor oral hygiene, inadequate mesio-distal space for implant placement, presence of periodontal disease, smoking, an American Society of Anesthesiologists (ASA) score of ≥II, or a vertical bony defect of less than 5 mm in the labial socket wall after tooth extraction. The primary outcome, change in marginal bone level, was analyzed using a per-protocol strategy. Normally distributed data were summarized using means and confidence intervals and compared with the independent samples t-test, while non-normally distributed data were described using medians and interquartile ranges and compared using the Mann-Whitney U test. To check the robustness of the findings, sensitivity analyses were conducted, including an intention-to-treat analysis. For outcomes with repeated measurements, multivariable linear mixed-effect models were utilized to examine differences between the treatment groups over time. All statistical analyses were performed using the R software (version 4.0.5), and a p-value less than 0.05 was the criterion for statistical significance. After 10 years, the mean marginal bone level change was −0.71 ± 0.59 mm in the Immediate Group and −0.36 ± 0.39 mm in the Delayed Group, with no statistically significant difference between them (p = 0.063). Secondary outcomes showed no significant variations between the two groups. Immediate implant placement with bone augmentation in postextraction sockets with buccal bony defects ≥5 mm yielded similar long-term outcomes to delayed implant placement after ridge preservation in the aesth","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 2","pages":"80-82"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-13DOI: 10.1038/s41432-025-01151-6
Shubham Sareen, Shipra Gupta, Lata Goyal
Liu J, Huang Y, Huang J, Yang W, Tao R. Effects of ozone therapy as an adjuvant in the treatment of periodontitis: a systematic review and meta-analysis. BMC Oral Health 2025; 25: 335. The authors conducted a systematic search across: 1. PubMed (MEDLINE); 2. Embase; 3. Cochrane Central Register of Controlled Trials (CENTRAL). Key question Does adjunctive ozone therapy improve periodontal clinical parameters (probing depth, gingival inflammation, bleeding, plaque levels, and attachment loss) in patients with chronic periodontitis compared to conventional scaling and root planing (SRP) alone? The study follows the PICO framework: 1. Population: Patients with chronic periodontitis; 2. Intervention: SRP + ozone therapy (ozonated water or gaseous ozone); 3. Comparison: SRP + placebo (e.g., saline, distilled water) or no adjunct; 4. Outcomes: Probing depth (PD), gingival index (GI), bleeding on probing (BOP), plaque index (PI), and clinical attachment level (CAL). Search strategy: Combined Medical Subject Headings (MeSH) terms and free-text keywords related to ozone (“Ozone,” “Ozonated water,” “Gaseous ozone”) and periodontitis (“Chronic periodontitis,” “Periodontal therapy”). Inclusion criteria: Study Design: 1. Only randomized controlled trials (RCTs); 2. Participants: Adults with chronic periodontitis (no systemic diseases or pregnancy). 3. Intervention: SRP + ozone therapy (either ozonated water irrigation or gaseous ozone insufflation). 4. Control: SRP + placebo (e.g., saline, distilled water) or no adjunct. 5. Outcomes: At least one of the following—PD, GI, BOP, PI, or CAL. Exclusion criteria: 1. Animal/in vitro studies; 2. Studies involving antibiotics, lasers, or other adjuncts; 3. Incomplete data or non-RCT designs. Screening process: 1. Initial Search: 99 records identified; 2. After Duplicate Removal: 62 studies screened; 3. Full-Text Review: 22 articles assessed, 13 met inclusion criteria. Final included studies: 1. 8 used ozonated water (concentration range: 2–85 μg/mL); 2. 5 used gaseous ozone (varying exposure times); 3. Follow-up periods: 4 weeks to 3 months. Data collection: 1. Two independent reviewers extracted data to minimize bias; 2. Extracted variables: study design, sample size, ozone concentration, application method, follow-up duration, and clinical outcomes. Statistical analysis: 1. Primary effect measure: weighted mean difference (WMD) with 95% confidence intervals (CI). 2. Heterogeneity assessed via I2 statistic: (a) For Low (0–50%): Fixed-effects model was used. (b) For High (>50%): Random-effects model was applied. 3. Sensitivity Analysis: Excluded studies one by one to assess robustness. 4. Publication Bias: Evaluated via funnel plots and Egger’s test. 1. Probing Depth (PD) reduction: (a) 12 studies, 655 patients. (b) Significant improvement (WMD = −0.26 mm, P = 0.01). (c) Heterogeneity: High (I2 = 78%). (d) Interpretation: Ozone + SRP reduces pocket depth more than SRP alone, but variability in ozone application meth
{"title":"Ozone therapy as a complementary approach in periodontal therapeutics","authors":"Shubham Sareen, Shipra Gupta, Lata Goyal","doi":"10.1038/s41432-025-01151-6","DOIUrl":"10.1038/s41432-025-01151-6","url":null,"abstract":"Liu J, Huang Y, Huang J, Yang W, Tao R. Effects of ozone therapy as an adjuvant in the treatment of periodontitis: a systematic review and meta-analysis. BMC Oral Health 2025; 25: 335. The authors conducted a systematic search across: 1. PubMed (MEDLINE); 2. Embase; 3. Cochrane Central Register of Controlled Trials (CENTRAL). Key question Does adjunctive ozone therapy improve periodontal clinical parameters (probing depth, gingival inflammation, bleeding, plaque levels, and attachment loss) in patients with chronic periodontitis compared to conventional scaling and root planing (SRP) alone? The study follows the PICO framework: 1. Population: Patients with chronic periodontitis; 2. Intervention: SRP + ozone therapy (ozonated water or gaseous ozone); 3. Comparison: SRP + placebo (e.g., saline, distilled water) or no adjunct; 4. Outcomes: Probing depth (PD), gingival index (GI), bleeding on probing (BOP), plaque index (PI), and clinical attachment level (CAL). Search strategy: Combined Medical Subject Headings (MeSH) terms and free-text keywords related to ozone (“Ozone,” “Ozonated water,” “Gaseous ozone”) and periodontitis (“Chronic periodontitis,” “Periodontal therapy”). Inclusion criteria: Study Design: 1. Only randomized controlled trials (RCTs); 2. Participants: Adults with chronic periodontitis (no systemic diseases or pregnancy). 3. Intervention: SRP + ozone therapy (either ozonated water irrigation or gaseous ozone insufflation). 4. Control: SRP + placebo (e.g., saline, distilled water) or no adjunct. 5. Outcomes: At least one of the following—PD, GI, BOP, PI, or CAL. Exclusion criteria: 1. Animal/in vitro studies; 2. Studies involving antibiotics, lasers, or other adjuncts; 3. Incomplete data or non-RCT designs. Screening process: 1. Initial Search: 99 records identified; 2. After Duplicate Removal: 62 studies screened; 3. Full-Text Review: 22 articles assessed, 13 met inclusion criteria. Final included studies: 1. 8 used ozonated water (concentration range: 2–85 μg/mL); 2. 5 used gaseous ozone (varying exposure times); 3. Follow-up periods: 4 weeks to 3 months. Data collection: 1. Two independent reviewers extracted data to minimize bias; 2. Extracted variables: study design, sample size, ozone concentration, application method, follow-up duration, and clinical outcomes. Statistical analysis: 1. Primary effect measure: weighted mean difference (WMD) with 95% confidence intervals (CI). 2. Heterogeneity assessed via I2 statistic: (a) For Low (0–50%): Fixed-effects model was used. (b) For High (>50%): Random-effects model was applied. 3. Sensitivity Analysis: Excluded studies one by one to assess robustness. 4. Publication Bias: Evaluated via funnel plots and Egger’s test. 1. Probing Depth (PD) reduction: (a) 12 studies, 655 patients. (b) Significant improvement (WMD = −0.26 mm, P = 0.01). (c) Heterogeneity: High (I2 = 78%). (d) Interpretation: Ozone + SRP reduces pocket depth more than SRP alone, but variability in ozone application meth","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 2","pages":"91-92"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-13DOI: 10.1038/s41432-025-01157-0
Rawan Kahatab, Ioannis Polyzois
Ferreira R O, Frazão D R, Ferreira M K M et al. Periodontal disease and sports performance: a systematic review and meta-analysis. Res Sports Med. 2024; https://doi.org/10.1080/15438627.2023.2235048 . A comprehensive search was conducted across PubMed, Scopus, Web of Science, Cochrane Library, and LILACS, supplemented by gray literature searches using OpenGrey and Google Scholar. The search strategy combined MeSH terms and free-text keywords related to “athletes” or “exercise,” and “periodontitis,” “periodontal disease,” or “gingivitis,” along with “sports performance,” adjusted for each database’s syntax References were managed using EndNote X9, with duplicates removed. Eligibility screening excluded opinion papers, technical articles, guidelines, and animal studies. Full texts of relevant articles were reviewed, and additional articles were identified through citation tracking. Two reviewers independently performed the selection, with disagreements resolved by a third examiner. The study selection in this systematic review involved identifying observational studies that compared professional athletes with periodontal disease (the case group) to those with a healthy periodontium (the control group). The studies included in the review were required to focus on the effects of periodontal disease on sports performance, with no restrictions on the type of sport. Specifically, the researchers developed a PECO statement and conducted searches in online databases for relevant studies published until April 2022, eventually including cross-sectional, case-control, and cohort studies that met their eligibility criteria. For each selected publication, data was collected on various characteristics, including publication year, study design, participant demographics (source and sample size), participants’ ages, periodontal assessment methods, sports performance assessment, and outcomes. If necessary, study authors were contacted via email to obtain missing data. Quality Assessment: The methodological quality of the studies was evaluated using the Joanna Briggs Institute’s checklist for prevalence studies. Each study was assessed based on criteria such as the clarity of sample inclusion criteria, detailed descriptions of study subjects and settings, validity and reliability of exposure measurements, identification of confounding factors, and appropriateness of statistical analyses. Data analysis for this study was conducted using RevMan software to determine the relationship between periodontal disease and self-perceived sports performance, measured through Oral Impact on Daily Performance (OIDP) questionnaires; a meta-analysis was conducted using odds ratios (OR) with 95% confidence intervals (CI), comparing the presence of periodontal disease in performance-affected (case) and unaffected (control) groups. A random-effects model was applied when methodological heterogeneity existed, and heterogeneity was assessed via the I² index along with sensitivity analys
评述：Ferreira R O， fraz O D R， Ferreira M K M等。牙周病与运动表现：一项系统综述和荟萃分析。Res Sports Med. 2024；https://doi.org/10.1080/15438627.2023.2235048 .数据来源：通过PubMed、Scopus、Web of Science、Cochrane Library和LILACS进行全面检索，并辅以使用OpenGrey和谷歌Scholar进行灰色文献检索。搜索策略结合了MeSH术语和与“运动员”或“运动”、“牙周炎”、“牙周病”或“牙龈炎”以及“运动表现”相关的自由文本关键字，并根据每个数据库的语法进行了调整，使用EndNote X9管理参考文献，删除了重复的内容。资格筛选排除了意见论文、技术文章、指南和动物研究。对相关文章的全文进行审阅，并通过引文跟踪确定其他文章。两名审查员独立进行选择，分歧由第三名审查员解决。研究选择：本系统综述的研究选择包括确定观察性研究，将患有牙周病的专业运动员（病例组）与牙周健康的运动员（对照组）进行比较。审查中包括的研究被要求关注牙周病对运动表现的影响，对运动类型没有限制。具体而言，研究人员制定了PECO声明，并在在线数据库中检索了截至2022年4月发表的相关研究，最终包括符合其资格标准的横断面、病例对照和队列研究。数据提取与综合：对于每份选定的出版物，收集各种特征的数据，包括出版年份、研究设计、参与者人口统计（来源和样本量）、参与者年龄、牙周评估方法、运动表现评估和结果。如有必要，通过电子邮件联系研究作者以获取缺失的数据。质量评估：使用乔安娜布里格斯研究所的流行病学研究检查表对研究的方法学质量进行评估。每项研究的评估标准包括样本纳入标准的清晰度、研究对象和环境的详细描述、暴露测量的有效性和可靠性、混杂因素的识别以及统计分析的适当性。本研究使用RevMan软件进行数据分析，通过口腔对日常表现的影响（OIDP）问卷调查，确定牙周病与自我感知运动表现之间的关系；采用95%可信区间（CI）的优势比（OR）进行荟萃分析，比较表现受影响组（病例）和未受影响组（对照组）牙周病的存在。当方法学存在异质性时，采用随机效应模型，并通过I²指数和敏感性分析来评估异质性，以评估单个研究对总体结果的影响。在适当的地方生成漏斗图来评估发表偏倚。进行敏感性分析以验证单个研究或组研究对汇总结果的影响。使用GRADE方法评估总体证据质量，该方法考虑了诸如偏倚风险、不一致性和间隔性等因素。结果：在确定的793篇参考文献中，14篇被选择用于应用资格标准进行全文评估，导致8篇文章被纳入meta分析。这些研究主要采用横断面设计，涉及的运动员年龄从16岁到47岁不等。各种运动都有代表，包括田径、拳击和足球。六项研究表明牙周病与自我感知运动表现之间存在显著关系，而两项研究没有发现关联。荟萃分析显示，通过OIDP问卷测量，运动表现下降与牙周病相关的风险增加1.5倍。具体来说，优势比为1.55 (95% CI: 1.04 - 2.31)，可以肯定地说，患有牙周病的运动员更有可能报告成绩下降。结论：通过本系统综述和荟萃分析可以得出结论，牙周病与运动员自我感知运动成绩下降之间存在显著关联。研究结果强调了保持良好口腔健康的重要性。运动员应该优先考虑牙周健康，参与有效的口腔卫生实践，及时寻求牙周问题的治疗，以优化他们的表现。
{"title":"Enhancing athletic performance: the critical role of oral health in sports","authors":"Rawan Kahatab, Ioannis Polyzois","doi":"10.1038/s41432-025-01157-0","DOIUrl":"10.1038/s41432-025-01157-0","url":null,"abstract":"Ferreira R O, Frazão D R, Ferreira M K M et al. Periodontal disease and sports performance: a systematic review and meta-analysis. Res Sports Med. 2024; https://doi.org/10.1080/15438627.2023.2235048 . A comprehensive search was conducted across PubMed, Scopus, Web of Science, Cochrane Library, and LILACS, supplemented by gray literature searches using OpenGrey and Google Scholar. The search strategy combined MeSH terms and free-text keywords related to “athletes” or “exercise,” and “periodontitis,” “periodontal disease,” or “gingivitis,” along with “sports performance,” adjusted for each database’s syntax References were managed using EndNote X9, with duplicates removed. Eligibility screening excluded opinion papers, technical articles, guidelines, and animal studies. Full texts of relevant articles were reviewed, and additional articles were identified through citation tracking. Two reviewers independently performed the selection, with disagreements resolved by a third examiner. The study selection in this systematic review involved identifying observational studies that compared professional athletes with periodontal disease (the case group) to those with a healthy periodontium (the control group). The studies included in the review were required to focus on the effects of periodontal disease on sports performance, with no restrictions on the type of sport. Specifically, the researchers developed a PECO statement and conducted searches in online databases for relevant studies published until April 2022, eventually including cross-sectional, case-control, and cohort studies that met their eligibility criteria. For each selected publication, data was collected on various characteristics, including publication year, study design, participant demographics (source and sample size), participants’ ages, periodontal assessment methods, sports performance assessment, and outcomes. If necessary, study authors were contacted via email to obtain missing data. Quality Assessment: The methodological quality of the studies was evaluated using the Joanna Briggs Institute’s checklist for prevalence studies. Each study was assessed based on criteria such as the clarity of sample inclusion criteria, detailed descriptions of study subjects and settings, validity and reliability of exposure measurements, identification of confounding factors, and appropriateness of statistical analyses. Data analysis for this study was conducted using RevMan software to determine the relationship between periodontal disease and self-perceived sports performance, measured through Oral Impact on Daily Performance (OIDP) questionnaires; a meta-analysis was conducted using odds ratios (OR) with 95% confidence intervals (CI), comparing the presence of periodontal disease in performance-affected (case) and unaffected (control) groups. A random-effects model was applied when methodological heterogeneity existed, and heterogeneity was assessed via the I² index along with sensitivity analys","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 2","pages":"105-106"},"PeriodicalIF":2.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-12DOI: 10.1038/s41432-025-01146-3
J. Shanti Swarup, Rathika Thomas, Jessica Rucharitha, V. R. Arunkumar, Vasanthi V
Hydroxyapatite (HAp) derived from chicken eggshells has recently gained significant interest in tissue engineering and regenerative medicine. This paper aims to review the synthesis, properties and applications of eggshell-derived hydroxyapatite (E-HAp) in dentistry. A comprehensive literature search was conducted in PubMed and Scopus databases, along with a grey literature search. The references of selected studies were also manually reviewed to identify additional relevant articles. No restrictions were applied for language or publication year. Two independent reviewers carried out the study selection and data extraction processes. Seventeen studies met the inclusion criteria and were included in the qualitative analysis. Most studies were in vitro investigations focused on applications such as dentinal tubule sealing (n = 4) and remineralization of initial enamel caries lesions (n = 4). E-HAp was also studied for tissue engineering applications, including alveolar ridge preservation as a bone graft material (n = 5) and periodontal regeneration (n = 2). Additional applications included regenerative endodontics (n = 3) and use as a pulp capping agent (n = 2). E-HAp shows a wide range of applications in dentistry, particularly in tissue engineering and regenerative dentistry, marking it as a promising biomaterial in dentistry.
{"title":"Eggshell-derived hydroxyapatite as a biomaterial in dentistry: a scoping review of synthesis, properties and applications","authors":"J. Shanti Swarup, Rathika Thomas, Jessica Rucharitha, V. R. Arunkumar, Vasanthi V","doi":"10.1038/s41432-025-01146-3","DOIUrl":"10.1038/s41432-025-01146-3","url":null,"abstract":"Hydroxyapatite (HAp) derived from chicken eggshells has recently gained significant interest in tissue engineering and regenerative medicine. This paper aims to review the synthesis, properties and applications of eggshell-derived hydroxyapatite (E-HAp) in dentistry. A comprehensive literature search was conducted in PubMed and Scopus databases, along with a grey literature search. The references of selected studies were also manually reviewed to identify additional relevant articles. No restrictions were applied for language or publication year. Two independent reviewers carried out the study selection and data extraction processes. Seventeen studies met the inclusion criteria and were included in the qualitative analysis. Most studies were in vitro investigations focused on applications such as dentinal tubule sealing (n = 4) and remineralization of initial enamel caries lesions (n = 4). E-HAp was also studied for tissue engineering applications, including alveolar ridge preservation as a bone graft material (n = 5) and periodontal regeneration (n = 2). Additional applications included regenerative endodontics (n = 3) and use as a pulp capping agent (n = 2). E-HAp shows a wide range of applications in dentistry, particularly in tissue engineering and regenerative dentistry, marking it as a promising biomaterial in dentistry.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 3","pages":"153-153"},"PeriodicalIF":2.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Oral diseases are a major public health concern in Low and Middle Income Countries (LMICs), where effective treatment requires multiple appointments. Despite its importance, limited research has explored appointment adherence among adults in these settings. This scoping review identifies the barriers and facilitators to attending dental care appointments in LMICs. The current review followed JBI Scoping Review Methodology. The Databases of Dentistry, Oral Sciences Source (EBSCO), MEDLINE (Ovid), Embase (Ovid), Cochrane CENTRAL, Scopus and grey literature sources were searched systematically from inception till November 2024. Two independent reviewers performed data extraction using a customized JBI data extraction form. The Theoretical Domains Framework categorized barriers and facilitators of dental appointment keeping. Findings were tabulated and synthesized narratively with recommendations to improve dental attendance. Ten articles met the inclusion criteria after being screened through 5571 titles, abstracts, and 210 full texts. Knowledge, social and professional roles and identity, beliefs about capabilities, consequences, memory, attention, decision-making processes, environmental context and resources, social influence, and emotion are the main domains under which barriers and facilitators were identified. Environmental context and resource constraints were the most common barriers, while social influence was the main facilitator. The dental appointment adherence issues were determined to be comparable in public practice and university settings. It is necessary to acknowledge the barriers and facilitators to dental appointment keeping to improve the effectiveness of the dental health system, ensure continuity of care, and encourage better patient-doctor relationships. Tailored interventions are required in the dental setting to effectively manage and reduce disparities in patient care.
{"title":"Barriers to and facilitators for attending dental care appointments among adults in low- and middle-income countries: a scoping review","authors":"Vineetha Karuveettil, Swati Sapna, Praneetha Jain, Gurleen Kaur Anand","doi":"10.1038/s41432-025-01148-1","DOIUrl":"10.1038/s41432-025-01148-1","url":null,"abstract":"Oral diseases are a major public health concern in Low and Middle Income Countries (LMICs), where effective treatment requires multiple appointments. Despite its importance, limited research has explored appointment adherence among adults in these settings. This scoping review identifies the barriers and facilitators to attending dental care appointments in LMICs. The current review followed JBI Scoping Review Methodology. The Databases of Dentistry, Oral Sciences Source (EBSCO), MEDLINE (Ovid), Embase (Ovid), Cochrane CENTRAL, Scopus and grey literature sources were searched systematically from inception till November 2024. Two independent reviewers performed data extraction using a customized JBI data extraction form. The Theoretical Domains Framework categorized barriers and facilitators of dental appointment keeping. Findings were tabulated and synthesized narratively with recommendations to improve dental attendance. Ten articles met the inclusion criteria after being screened through 5571 titles, abstracts, and 210 full texts. Knowledge, social and professional roles and identity, beliefs about capabilities, consequences, memory, attention, decision-making processes, environmental context and resources, social influence, and emotion are the main domains under which barriers and facilitators were identified. Environmental context and resource constraints were the most common barriers, while social influence was the main facilitator. The dental appointment adherence issues were determined to be comparable in public practice and university settings. It is necessary to acknowledge the barriers and facilitators to dental appointment keeping to improve the effectiveness of the dental health system, ensure continuity of care, and encourage better patient-doctor relationships. Tailored interventions are required in the dental setting to effectively manage and reduce disparities in patient care.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 3","pages":"150-151"},"PeriodicalIF":2.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-10DOI: 10.1038/s41432-025-01144-5
Rodolfo de Carvalho Oliveira, Jonathan Rafael Garbim, Ana Laura Passaro, Tamara Kerber Tedesco, Daniela Prócida Raggio
Common causes of destruction in primary anterior teeth include dental caries and trauma. This systematic review evaluated the success rate of restorative techniques for these cases. Systematic searches were conducted in Medline (PubMed), Scopus, Web of Science, Cochrane, Embase, and ProQuest until February 2024. Randomized controlled trials and non-randomized studies of interventions with ≥12 months of follow-up were included. Exclusion criteria were: studies with >30% loss to follow-up, unclear evaluation criteria, management under general anesthesia, unhealthy patients, or lacking individual success data. A meta-analysis assessed success rates, with subgroup analyses. Risk of bias was evaluated using RoB 2 and ROBINS-I, and evidence certainty was assessed using the GRADE system. Eight studies involving 852 teeth from 271 children aged 2–9 years, with follow-ups of 3–36 months, were included. The meta-analysis revealed a 71% success rate at 12 months for all techniques. Strip crowns (79%) and zirconia crowns (70%) had the highest success rates for teeth without endodontic treatment. Intracanal posts (resin or glass fiber) achieved an 83% success rate for teeth requiring endodontic treatment. Evidence certainty was low. Strip crowns and zirconia crowns performed well for teeth without endodontic treatment, with strip crowns offering a simpler and less technique-sensitive option. Biological restorations had poorer outcomes due to their complexity, sensitivity, and the need for a tooth biobank, raising legal and logistical challenges. Although zirconia crowns require extensive subgingival preparation, they align less with minimally invasive principles compared to strip crowns. Intracanal posts showed high success rates for teeth needing endodontic treatment, regardless of the material used. Strip crowns appear to be a suitable option for restoring primary anterior teeth that do not require endodontic treatment. For teeth requiring endodontic treatment, the use of intracanal posts combined with strip crowns seems to yield satisfactory results.
目的：造成初级前牙破坏的常见原因包括龋齿和外伤。本系统综述评估了这些病例的修复技术的成功率。方法：系统检索Medline （PubMed）、Scopus、Web of Science、Cochrane、Embase和ProQuest，检索截止至2024年2月。纳入随访≥12个月的干预措施的随机对照试验和非随机研究。排除标准为：> ~ 30%随访损失、评价标准不明确、全麻下管理、患者身体不健康或缺乏个体成功数据的研究。荟萃分析评估了成功率，并进行了亚组分析。使用rob2和ROBINS-I评估偏倚风险，使用GRADE系统评估证据确定性。结果：纳入8项研究，涉及271例2 ~ 9岁儿童852颗牙齿，随访3 ~ 36个月。荟萃分析显示，所有技术的12个月成功率为71%。条带冠（79%）和氧化锆冠（70%）对未进行根管治疗的牙齿成功率最高。对于需要根管治疗的牙齿，管内桩（树脂或玻璃纤维）的成功率为83%。证据确定性较低。讨论：条状冠和氧化锆冠在没有根管治疗的牙齿上表现良好，条状冠提供了一种更简单、更低技术敏感性的选择。生物修复由于其复杂性、敏感性和对牙齿生物库的需求，增加了法律和后勤方面的挑战，结果较差。虽然氧化锆冠需要广泛的龈下准备，但与条状冠相比，它们更不符合微创原则。管内桩显示高成功率的牙齿需要根管治疗，无论使用的材料。结论：条带冠是一种不需要根管治疗的修复前牙的合适选择。对于需要根管治疗的牙齿，使用管内桩结合条状冠似乎能产生令人满意的结果。
{"title":"Restorative strategies for deciduous anterior teeth: A systematic review and meta-analysis","authors":"Rodolfo de Carvalho Oliveira, Jonathan Rafael Garbim, Ana Laura Passaro, Tamara Kerber Tedesco, Daniela Prócida Raggio","doi":"10.1038/s41432-025-01144-5","DOIUrl":"10.1038/s41432-025-01144-5","url":null,"abstract":"Common causes of destruction in primary anterior teeth include dental caries and trauma. This systematic review evaluated the success rate of restorative techniques for these cases. Systematic searches were conducted in Medline (PubMed), Scopus, Web of Science, Cochrane, Embase, and ProQuest until February 2024. Randomized controlled trials and non-randomized studies of interventions with ≥12 months of follow-up were included. Exclusion criteria were: studies with >30% loss to follow-up, unclear evaluation criteria, management under general anesthesia, unhealthy patients, or lacking individual success data. A meta-analysis assessed success rates, with subgroup analyses. Risk of bias was evaluated using RoB 2 and ROBINS-I, and evidence certainty was assessed using the GRADE system. Eight studies involving 852 teeth from 271 children aged 2–9 years, with follow-ups of 3–36 months, were included. The meta-analysis revealed a 71% success rate at 12 months for all techniques. Strip crowns (79%) and zirconia crowns (70%) had the highest success rates for teeth without endodontic treatment. Intracanal posts (resin or glass fiber) achieved an 83% success rate for teeth requiring endodontic treatment. Evidence certainty was low. Strip crowns and zirconia crowns performed well for teeth without endodontic treatment, with strip crowns offering a simpler and less technique-sensitive option. Biological restorations had poorer outcomes due to their complexity, sensitivity, and the need for a tooth biobank, raising legal and logistical challenges. Although zirconia crowns require extensive subgingival preparation, they align less with minimally invasive principles compared to strip crowns. Intracanal posts showed high success rates for teeth needing endodontic treatment, regardless of the material used. Strip crowns appear to be a suitable option for restoring primary anterior teeth that do not require endodontic treatment. For teeth requiring endodontic treatment, the use of intracanal posts combined with strip crowns seems to yield satisfactory results.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 3","pages":"149-149"},"PeriodicalIF":2.3,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-09DOI: 10.1038/s41432-025-01154-3
C. Albert Yeung
Reis P P G, Jorge R C, Marañón-Vásquez G A, Fidalgo T K D S, Maia L C, Soviero V M. Impact of clinical consequences of pulp involvement due to caries on oral health-related quality of life in children and adolescents: a systematic review and meta-analysis. Caries Res 2025; 59: 71–83. Six electronic databases (PubMed, Scopus, Web of Science, Embase, BBO/VHL and Cochrane Library) and Google Scholar were searched in August 2022. Handsearching of the reference lists in the included studies were also carried out. Observational studies that assessed children/adolescents with clinical consequences of pulp involvement due to dental caries compared with those without them and its impact on their oral health-related quality of life (OHRQoL) were included. Pulp involvement should have been clinically assessed as pulp exposure (both vital and necrotic), abscess or fistula. Two review authors independently scanned the titles and available abstracts of all the articles identified through the electronic searches. The full text of studies that appeared to meet the inclusion criteria or for which there were insufficient data in the title and abstract were obtained to make a definitive decision. A third review author was consulted in cases of disagreement. All rejected studies and reasons for excluding them were recorded in the table for the list of excluded publications. Data were independently extracted from the included studies by two review authors using data extraction tables. The methodological quality assessment was conducted using the JBI critical appraisal checklist for analytical cross-sectional studies. The studies were grouped according to participants’ age range (preschoolers, schoolchildren and adolescents) and instruments used to measure OHRQoL. To be included in the meta-analyses, the studies should have used PUFA index. The mean differences (MD) or the standardised mean differences (SMD) were calculated for numerical outcome and odds ratio (OR) was calculated for dichotomous outcome. Robustness, heterogeneity, certainty of evidence and publication bias were assessed. All 29 included studies were cross-sectional and the sample sizes ranged from 30 to 1794 participants. Fourteen studies assessed preschoolers, nine assessed schoolchildren, four assessed adolescents and two assessed children and adolescents. Most studies used PUFA index to assess the exposure. ECOHIS (preschoolers) and CPQ (children/adolescents) were the main tools used to assess the outcome. Only five articles fully adhered to the quality criteria. The meta-analyses revealed the following main results: (a) preschoolers: MD −10.79 (95% CI −16.50 to −5.09); (b) schoolchildren: MD −5.12 (95% CI −7.51 to −2.72); (c) adolescents: MD −1.86 (95% CI −4.59 to 0.87); (d) overall impact: SMD −2.18 (95% CI −3.21 to −1.15) and OR 0.52 (95% CI 0.30–0.90). Clinical consequences of pulp involvement negatively impacted the OHRQoL of children. In adolescents, this impact was not observed. However, the
[1]王晓明，王晓明，王晓明，王晓明，王晓明。口腔龋病对儿童和青少年口腔健康的影响：一项系统评价和meta分析。龋齿研究2025；59: 71 - 83。数据来源：检索于2022年8月PubMed、Scopus、Web of Science、Embase、BBO/VHL、Cochrane Library等6个电子数据库和谷歌Scholar。手工检索纳入研究的参考文献表。研究选择：纳入观察性研究，评估儿童/青少年因龋齿而受牙髓损害的临床后果与未受龋齿影响的儿童/青少年及其对口腔健康相关生活质量（OHRQoL）的影响。牙髓受累应被临床评估为牙髓暴露（包括重要的和坏死的）、脓肿或瘘管。两位综述作者独立扫描了通过电子检索确定的所有文章的标题和可用摘要。获得了似乎符合纳入标准或标题和摘要中数据不足的研究的全文，以作出明确的决定。在意见不一致的情况下，咨询第三位综述作者。所有被拒绝的研究及其被排除的原因都记录在被排除出版物列表的表中。数据提取和综合：由两位综述作者使用数据提取表独立地从纳入的研究中提取数据。方法学质量评估使用JBI关键评估清单进行分析性横断面研究。这些研究根据参与者的年龄范围（学龄前儿童、学龄儿童和青少年）和测量OHRQoL所用的工具进行分组。纳入meta分析的研究应该使用PUFA指数。数值结果计算平均差异（MD）或标准化平均差异（SMD），二分类结果计算优势比（or）。评估稳健性、异质性、证据确定性和发表偏倚。结果：所有纳入的29项研究均为横断面研究，样本量从30至1794名参与者不等。14项研究评估了学龄前儿童，9项评估了学龄儿童，4项评估了青少年，2项评估了儿童和青少年。大多数研究使用PUFA指数来评估暴露程度。ECOHIS（学龄前儿童）和CPQ（儿童/青少年）是评估结果的主要工具。只有5件物品完全符合质量标准。meta分析揭示了以下主要结果：(a)学龄前儿童：MD为-10.79 (95% CI为-16.50 ~ -5.09)；(b)学童：MD为-5.12 (95% CI为-7.51至-2.72)；(c)青少年：MD -1.86 (95% CI -4.59 ~ 0.87)；(d)总体影响：SMD -2.18 （95% CI -3.21至-1.15）和OR 0.52 （95% CI 0.30-0.90）。结论：牙髓受累的临床后果对儿童的OHRQoL有负面影响。在青少年中，没有观察到这种影响。然而，这些结果必须谨慎解释，因为证据的确定性非常低，而且存在偏倚风险和相当大的异质性，表明结果不一致。
{"title":"Do clinical consequences of pulp involvement due to dental caries cause impact on quality of life of children and adolescents?","authors":"C. Albert Yeung","doi":"10.1038/s41432-025-01154-3","DOIUrl":"10.1038/s41432-025-01154-3","url":null,"abstract":"Reis P P G, Jorge R C, Marañón-Vásquez G A, Fidalgo T K D S, Maia L C, Soviero V M. Impact of clinical consequences of pulp involvement due to caries on oral health-related quality of life in children and adolescents: a systematic review and meta-analysis. Caries Res 2025; 59: 71–83. Six electronic databases (PubMed, Scopus, Web of Science, Embase, BBO/VHL and Cochrane Library) and Google Scholar were searched in August 2022. Handsearching of the reference lists in the included studies were also carried out. Observational studies that assessed children/adolescents with clinical consequences of pulp involvement due to dental caries compared with those without them and its impact on their oral health-related quality of life (OHRQoL) were included. Pulp involvement should have been clinically assessed as pulp exposure (both vital and necrotic), abscess or fistula. Two review authors independently scanned the titles and available abstracts of all the articles identified through the electronic searches. The full text of studies that appeared to meet the inclusion criteria or for which there were insufficient data in the title and abstract were obtained to make a definitive decision. A third review author was consulted in cases of disagreement. All rejected studies and reasons for excluding them were recorded in the table for the list of excluded publications. Data were independently extracted from the included studies by two review authors using data extraction tables. The methodological quality assessment was conducted using the JBI critical appraisal checklist for analytical cross-sectional studies. The studies were grouped according to participants’ age range (preschoolers, schoolchildren and adolescents) and instruments used to measure OHRQoL. To be included in the meta-analyses, the studies should have used PUFA index. The mean differences (MD) or the standardised mean differences (SMD) were calculated for numerical outcome and odds ratio (OR) was calculated for dichotomous outcome. Robustness, heterogeneity, certainty of evidence and publication bias were assessed. All 29 included studies were cross-sectional and the sample sizes ranged from 30 to 1794 participants. Fourteen studies assessed preschoolers, nine assessed schoolchildren, four assessed adolescents and two assessed children and adolescents. Most studies used PUFA index to assess the exposure. ECOHIS (preschoolers) and CPQ (children/adolescents) were the main tools used to assess the outcome. Only five articles fully adhered to the quality criteria. The meta-analyses revealed the following main results: (a) preschoolers: MD −10.79 (95% CI −16.50 to −5.09); (b) schoolchildren: MD −5.12 (95% CI −7.51 to −2.72); (c) adolescents: MD −1.86 (95% CI −4.59 to 0.87); (d) overall impact: SMD −2.18 (95% CI −3.21 to −1.15) and OR 0.52 (95% CI 0.30–0.90). Clinical consequences of pulp involvement negatively impacted the OHRQoL of children. In adolescents, this impact was not observed. However, the","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 2","pages":"95-96"},"PeriodicalIF":2.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144062411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-05-09DOI: 10.1038/s41432-025-01150-7
Lata Goyal, Komal Kaur Saroya, Shipra Gupta, Shubham Sareen
Ma X, Zhang Y, Wang J et al. Association between denture restoration for tooth loss and cognitive impairment: a systematic review and meta-analysis. J Prosthodont Res 2025; https://doi.org/10.2186/jpr.JPR_D_24_00060 . A search was conducted across five electronic databases, including PubMed, EMBASE, Cochrane Library, MEDLINE, and CNKI, from January 2000 to January 2024. The search strategy included keywords related to tooth loss, dentures, cognitive function, memory loss and dementia. Reference lists of relevant studies were also screened to identify additional articles. The search was limited to the English language only. Observational studies examining the association between denture restoration and cognitive impairment were included. Eligible studies had to report cognitive impairment or dementia as the outcome and denture restoration as the exposure factor. Six studies with a total of 24,252 participants met the inclusion criteria. Two independent reviewers extracted relevant data, including study design, participant characteristics, dental status, cognitive assessment methods, and statistical results. Meta-analysis was conducted using risk ratios (RR) with 95% confidence intervals (CI), applying a random-effects model due to clinical and methodological variations. Newcastle-Ottawa Scale and the Agency for Healthcare research and quality scale were used for quality assessment of included studies. Beg- Mazumdar and Egger regression tests were used to assess the publication bias. The meta-analysis revealed that participants with tooth loss without dentures had a 1.27-fold higher odds of having cognitive impairment, whereas those with dentures had only a 1.02-fold odds. A dose-response analysis showed that each additional missing tooth increased the cognitive impairment risk by 1.009 times in the non-denture group, while the denture group exhibited a lower risk increase of 1.003 times. Heterogeneity was influenced by follow-up duration and cognitive assessment tools. There was significant evidence of publication bias in non denture group as compared to the denture restoration group which showed nonsignificant evidence of publication bias. This study suggests denture restoration is associated with a reduced risk of cognitive impairment in individuals with tooth loss. The findings highlight the potential protective role of timely denture rehabilitation in mitigating cognitive decline. Future research should focus on longitudinal and interventional studies to establish causality.
{"title":"Association between restoration of missing teeth with dentures and cognitive function","authors":"Lata Goyal, Komal Kaur Saroya, Shipra Gupta, Shubham Sareen","doi":"10.1038/s41432-025-01150-7","DOIUrl":"10.1038/s41432-025-01150-7","url":null,"abstract":"Ma X, Zhang Y, Wang J et al. Association between denture restoration for tooth loss and cognitive impairment: a systematic review and meta-analysis. J Prosthodont Res 2025; https://doi.org/10.2186/jpr.JPR_D_24_00060 . A search was conducted across five electronic databases, including PubMed, EMBASE, Cochrane Library, MEDLINE, and CNKI, from January 2000 to January 2024. The search strategy included keywords related to tooth loss, dentures, cognitive function, memory loss and dementia. Reference lists of relevant studies were also screened to identify additional articles. The search was limited to the English language only. Observational studies examining the association between denture restoration and cognitive impairment were included. Eligible studies had to report cognitive impairment or dementia as the outcome and denture restoration as the exposure factor. Six studies with a total of 24,252 participants met the inclusion criteria. Two independent reviewers extracted relevant data, including study design, participant characteristics, dental status, cognitive assessment methods, and statistical results. Meta-analysis was conducted using risk ratios (RR) with 95% confidence intervals (CI), applying a random-effects model due to clinical and methodological variations. Newcastle-Ottawa Scale and the Agency for Healthcare research and quality scale were used for quality assessment of included studies. Beg- Mazumdar and Egger regression tests were used to assess the publication bias. The meta-analysis revealed that participants with tooth loss without dentures had a 1.27-fold higher odds of having cognitive impairment, whereas those with dentures had only a 1.02-fold odds. A dose-response analysis showed that each additional missing tooth increased the cognitive impairment risk by 1.009 times in the non-denture group, while the denture group exhibited a lower risk increase of 1.003 times. Heterogeneity was influenced by follow-up duration and cognitive assessment tools. There was significant evidence of publication bias in non denture group as compared to the denture restoration group which showed nonsignificant evidence of publication bias. This study suggests denture restoration is associated with a reduced risk of cognitive impairment in individuals with tooth loss. The findings highlight the potential protective role of timely denture rehabilitation in mitigating cognitive decline. Future research should focus on longitudinal and interventional studies to establish causality.","PeriodicalId":12234,"journal":{"name":"Evidence-based dentistry","volume":"26 2","pages":"85-86"},"PeriodicalIF":2.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：