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Do ultrasonic instrumentation and air polishing procedures adversely affect dental restorations? 超声仪器和空气抛光程序对牙齿修复有不利影响吗?
IF 2.3 Q3 Dentistry Pub Date : 2025-06-10 DOI: 10.1038/s41432-025-01169-w
Annabell Harman, Bryan Murchie
Esati J, Amran T, Weiger R, Alsulaimani L, Blatz M B, Eggmann F. Adverse effects of ultrasonic instrumentation and air polishing on dental restorations: a systematic review of laboratory studies. J Esthet Restor Dent 2025; https://doi.org/10.1111/jerd.13428 . A systematic review of the literature was conducted, assessing the potential for adverse effects on surface roughness and marginal integrity with use of ultrasonic instrumentation and air polishing on variety of dental restorations. With the aim to guide clinical practice to aid mitigation of adverse effects. Five databases: Cochrane Library, OpenGrey through DANS, PubMed, Scopus, and Web of Science, and supplemental manual searches were used to identify relevant literature. The review adhered to the PRISMA guidelines. Publications were included between 1978 and 2022. Population: dental restorations or restorative biomaterials in vitro. Intervention: ultrasonic instrumentation and/or air polishing. Comparison: no debridement procedure or paste polishing. Outcome: surface roughness and/or marginal quality. Forty-two laboratory studies were included in the final analysis. The studies evaluated data to answer the following research question: In specimens made of or featuring dental restorations or restorative biomaterials, how does the use of ultrasonic instrumentation and/or air polishing, compared with no debridement procedure or paste polishing, affect the surface roughness and/or marginal quality? Data extracted included: author(s) and year, laboratory studies, biomaterials evaluated, specimen quantity, specimen geometry, grouping methodology, types of ultrasonic and/or air polishing devices used, air polishing powders, device operational settings, application type and duration of ultrasonic and/or air polishing, assessments of surface roughness and marginal quality, and the observed effects on both surface roughness and marginal quality. Biomaterial assessed included: porcelain fused to metal (PFM), zirconia (ZrO2), lithium disilicate (LDS), polymer-infiltrated ceramic network material (PICN), fine-structure felspathic ceramic (FSFC), gold alloy, amalgam, resin-modified glass ionomer cements (RMGIC), conventional and flowable resin-based composite (RBC), and silorane-based RBCs restorations. Studies measured surface roughness via contact profilometry, scanning electron microscopy, and atomic force microscopy. Ra was used as a parameter for surface roughness. Stereomicroscopy and confocal laser microscopy were used to assess marginal quality. Risk of bias was assessed using the RoBDEMAT tool. Ultrasonic instrumentation and air polishing both negatively impacted surface roughness. Air polishing with sodium bicarbonate and calcium carbonate powders had a significantly greater effect on surface roughness, compared with erythritol and glycine powders. The surface roughness for RBCs and RMGICs were the most affected by ultrasonic instrumentation. In comparison, ZrO2 and LDS restorations were fou
[1]李建军,李建军,李建军,等。超声仪器与空气抛光对口腔修复体的影响研究综述。[J];https://doi.org/10.1111/jerd.13428目的:对文献进行系统回顾,评估超声仪器和空气抛光在各种牙科修复体中对表面粗糙度和边缘完整性的潜在不利影响。目的是指导临床实践,帮助减轻不良反应。数据来源:五个数据库:Cochrane Library、OpenGrey through DANS、PubMed、Scopus和Web of Science,并使用补充人工检索来识别相关文献。审查遵循PRISMA准则。研究选择:纳入1978 - 2022年间的出版物。人群:牙体修复体或体外修复生物材料。干预:超声波仪器和/或空气抛光。对比:无清创术,无膏体抛光。结果:表面粗糙度和/或边缘质量。最后的分析包括42项实验室研究。这些研究对数据进行了评估,以回答以下研究问题:在由牙齿修复体或修复性生物材料制成或以其为特征的标本中,与不使用清创程序或膏体抛光相比,使用超声仪器和/或空气抛光对表面粗糙度和/或边缘质量的影响如何?数据提取和合成:提取的数据包括:作者和年份、实验室研究、评估的生物材料、样品数量、样品几何形状、分组方法、使用的超声波和/或空气抛光设备的类型、空气抛光粉末、设备操作设置、超声波和/或空气抛光的应用类型和持续时间、表面粗糙度和边缘质量的评估,以及观察到的对表面粗糙度和边缘质量的影响。评估的生物材料包括:金属烤瓷(PFM)、氧化锆(ZrO2)、二硅酸锂(LDS)、聚合物浸润陶瓷网络材料(PICN)、精细结构felspathic陶瓷(FSFC)、金合金、汞合金、树脂改性玻璃离子水泥(RMGIC)、常规和可流动的树脂基复合材料(RBC)和硅烷基红细胞修复体。研究测量表面粗糙度通过接触轮廓术,扫描电子显微镜,和原子力显微镜。Ra作为表面粗糙度的参数。体视显微镜和激光共聚焦显微镜评估边缘质量。使用RoBDEMAT工具评估偏倚风险。结果:超声仪器和空气抛光对表面粗糙度均有负面影响。与赤藓糖醇和甘氨酸粉末相比,碳酸氢钠和碳酸钙粉末对表面粗糙度的影响更大。超声仪器对红细胞和rmgic表面粗糙度的影响最大。相比之下,ZrO2和LDS修复体的抗性水平最高。三项研究发现,使用橡胶杯和抛光膏可以减轻仪器仪表后表面粗糙度的增加。超声仪器和空气抛光方法都会导致不良的边际质量结果。瓷肩缘较窄(0.7毫米)的冠尤其容易受到影响。与RBC修复体相比,RMGIC和汞合金修复体对边缘质量的不利影响更大。结论:建议使用较少研磨粉的空气抛光,包括赤藓糖醇和甘氨酸,以减轻表面损伤和边缘界面的变化。另一个重要的临床考虑是修复材料的类型。与所有其他材料相比,高强度陶瓷修复体,如LDS和ZrO2,更耐表面粗化。
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引用次数: 0
Beyond statistical significance: when statistically significant post operative endodontic procedures might reduce pain affecting a minority of patients seen clinically 超过统计学意义:当有统计学意义的术后根管治疗可能减轻影响少数临床患者的疼痛时。
IF 2.3 Q3 Dentistry Pub Date : 2025-06-07 DOI: 10.1038/s41432-025-01158-z
Larry Z. Lockerman
Fatima S, Taneja S, Aggarwal V, Dheer A, Taneja P. Effect of cryotherapy, laser therapy and intraligamentary dexamethasone injection on post-treatment pain after single visit RCT-A double-blinded, randomized placebo-controlled trial. J Oral Biol Craniofac Res. 2025; https://doi.org/10.1016/j.jobcr.2025.01.005 . Patients were allocated to 4 groups or 25 subjects, Group-1: placebo, Group-2: Intraligamentary injection of dexamethasone, Group-3: cryotherapy (saline at a temperature of 2.5 °C was used as an irrigant in the canals prior to obturation), Group-4: cold laser therapy. Patients were instructed to record postoperative pain intensity and intake of analgesics after 6, 12, 24, 48, and 72 h. Researchgate.net, Google Scholar, pmc.ncbi.nlm.nih.gov Individuals diagnosed with molar necrotic pulps and symptomatic apical periodontitis. Systemically healthy patients, aged 18–65 years, diagnosed with symptomatic apical periodontitis in a mandibular molar requiring a primary endodontic procedure, with a preoperative VAS score of ≥7.3.2. Included patients with a history of allergy to any of the experimental drugs or local anesthetic solutions, patients who were medically compromised, and patients who had taken steroids, antibiotics, or analgesics within the previous 24 h. The study reported that patients in the placebo group exhibited statistically significantly higher intensity. Group 3 (cryotherapy) showed less pain at all time intervals. The study reported that the adjuvant pain management therapies reduced the intensity of postoperative pain and the frequency of analgesic intake.
Fatima S, Taneja S, Aggarwal V, Dheer A, Taneja P.冷冻治疗、激光治疗和韧带内注射地塞米松对单次访视后疼痛的影响中华口腔医学杂志;2009;https://doi.org/10.1016/j.jobcr.2025.01.005 .设计:患者被分为4组或25名受试者,组1:安慰剂,组2:韧带内注射地塞米松,组3:冷冻治疗(封闭前使用温度为2.5°C的生理盐水冲洗),组4:冷激光治疗。要求患者在术后6、12、24、48和72 h记录疼痛强度和镇痛药的摄入量。数据来源:Researchgate.net,谷歌Scholar, pmc.ncbi.nlm.nih.gov研究选择:诊断为臼齿坏死牙髓和症状性根尖牙周炎的个体。纳入标准:全身性健康患者,年龄18-65岁,诊断为下颌磨牙症状性根尖牙炎,需要进行初级牙髓治疗,术前VAS评分≥7.3.2。排除标准:包括对任何实验药物或局部麻醉溶液过敏史的患者,医学上有缺陷的患者,以及在过去24小时内服用类固醇、抗生素或镇痛药的患者。结果:研究报告安慰剂组患者表现出统计学上显著的高强度。第三组(冷冻治疗)在所有时间间隔内疼痛均减轻。研究结论:该研究报道了辅助疼痛管理治疗降低了术后疼痛的强度和镇痛药的摄入频率。
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引用次数: 0
What role do luting cements play in zirconia crown survival? 牙栓在氧化锆冠存活中起什么作用?
IF 2.3 Q3 Dentistry Pub Date : 2025-06-07 DOI: 10.1038/s41432-025-01172-1
Reanna Craig, Gerry McKenna
Torres C, Mailart M C, Ávila D et al. Influence of glass ionomer-based luting cements on the clinical success of zirconia crowns: randomized clinical trial. Oper Dent 2025; 50: 144–156. This 24-month prospective, split-mouth randomised clinical trial compared the performance of conventional glass ionomer cement (GIC) and resin-modified glass ionomer cement (RMGIC) for luting full-coverage ceramic-fused-to-zirconia crowns. Thirty participants were enrolled; 27 attended the 12-month review and 24 were assessed at the 24-month follow-up. Inclusion criteria included adults who needed two anterior or two posterior crowns. Silicone impressions were used to fabricate casts, which were scanned for CAD/CAM milling of zirconia copings. Clinical outcomes were assessed at 7 days, 12 months, and 24 months by calibrated, blinded examiners. The primary outcome was crown retention; whilst secondary outcomes included fracture, wear, pulpal response, patient satisfaction, plaque and bleeding indices, and marginal integrity. Assessments followed modified USPHS and FDI criteria. An intention-to-treat analysis using last observation carried forward was applied. Fisher’s Exact test compared anterior and posterior outcomes, while Kaplan–Meier estimates and log-rank tests were used to evaluate restoration survival (p < 0.05). Success rates recorded were 93.3% for GIC and 100% for RMGIC. For anterior crowns, GIC success declined to 83.3% at two years, while RMGIC maintained a 100% success rate throughout. Posterior crowns showed 100% success in both groups, with no loss of retention or secondary caries recorded. Both GIC and RMGIC demonstrated favourable short-term outcomes. However, anterior crowns cemented with GIC were more prone to failure, suggesting that crown location should inform cement selection. Optimising luting agent choice may improve long-term clinical success.
评论:Torres C, Mailart M C, Ávila D等。玻璃离子基luting水泥对氧化锆冠临床成功的影响:随机临床试验。开放凹痕2025;: 144 - 156。设计:这项为期24个月的前瞻性、裂口随机临床试验比较了传统玻璃离子水门合剂(GIC)和树脂改性玻璃离子水门合剂(RMGIC)用于全覆盖陶瓷-氧化锆烤瓷冠的性能。参与者:30名参与者;27人参加了为期12个月的审查,24人在24个月的随访中接受了评估。纳入标准包括需要两个前冠或两个后冠的成年人。使用硅树脂压模制造铸件,并对铸件进行扫描,以进行氧化锆涂层的CAD/CAM铣削。临床结果在7天、12个月和24个月时由校准的盲法检查者进行评估。数据分析:主要结局为冠固位;次要结果包括骨折、磨损、牙髓反应、患者满意度、斑块和出血指数以及边缘完整性。评估遵循修改后的USPHS和FDI标准。采用最后一次观察结转的意向治疗分析。Fisher’s Exact检验比较前后预后,Kaplan-Meier估计和log-rank检验用于评估修复存活率(p)。结果:GIC的成功率为93.3%,RMGIC的成功率为100%。对于前牙冠,GIC的成功率在两年内下降到83.3%,而RMGIC始终保持100%的成功率。两组后牙冠均100%成功,无固位损失或继发龋。结论:GIC和RMGIC均表现出良好的短期预后。然而,用GIC固接的前牙冠更容易失败,这表明牙冠的位置应该考虑到骨水泥的选择。优化药物选择可以提高长期临床成功率。
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引用次数: 0
Comparison of marker-based and marker-free registration techniques in dynamic navigation-guided implant surgery for fully and partially edentulous patients: A systematic review and meta-analysis 动态导航引导全牙和部分无牙患者种植手术中基于标记和无标记注册技术的比较:一项系统综述和荟萃分析。
IF 2.3 Q3 Dentistry Pub Date : 2025-06-04 DOI: 10.1038/s41432-025-01171-2
Meisha Gul, Baoxin Tao, Wenjie Zhou, Feng Wang, Yiqun Wu
To compare the accuracy of marker-based and marker-free registration methods in the context of dynamic navigation guided implant surgery for patients with partial or complete tooth loss. The review includes research articles written in English and Mandarin Chinese published between January 2013 and May 2025, from databases such as MEDLINE/PubMed, Scopus, Cochrane, Embase, China National Knowledge Infrastructure (CNKI) and Web of Science. Both laboratory-based and clinical investigations were taken into account. Thirteen studies, met the specified criteria for inclusion and underwent meta-analysis. Sub-analyses were performed to compare various registration modalities. The assessment of collective evidence was conducted using the GRADE system. No statistically significant differences were observed between registration methodologies i.e; marker based and marker free. Subgroup analysis highlighted a preference for marker-based methods, specifically those utilizing U-shaped markers and bone markers, especially in the lower jaw. No notable variations were noted in terms of time efficiency. Marker-free registration was favored for outcomes reported by patients. Both marker-free and marker-based registration strategies are considered feasible options. Selection should be made based on factors such as practicality, cost, efficiency, clinician preference, and patient-reported outcomes. The results should be interpreted with caution due to the considerable variability among studies, underscoring the necessity for more consistent and dependable data. CRD42024504573.
目的:比较基于标记和无标记的两种方法在动态导航引导种植手术中对部分或全部牙缺失患者的准确性。方法:本综述包括2013年1月至2025年5月期间发表的英文和普通话研究论文,来自MEDLINE/PubMed、Scopus、Cochrane、Embase、CNKI和Web of Science等数据库。实验室和临床调查都被考虑在内。13项研究符合指定的纳入标准并进行了荟萃分析。进行亚分析以比较各种登记方式。使用GRADE系统对集体证据进行评估。结果:两种登记方法(即;基于标记和标记免费。亚组分析强调了对基于标记的方法的偏好,特别是那些使用u形标记和骨标记的方法,特别是在下颌。在时间效率方面没有明显的变化。无标记注册对患者报告的结果更有利。结论:无标记和基于标记的注册策略都是可行的选择。应根据实用性、成本、效率、临床医生偏好和患者报告的结果等因素进行选择。由于研究之间存在相当大的可变性,因此应谨慎解释这些结果,强调需要更一致和可靠的数据。普洛斯彼罗注册号:CRD42024504573。
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引用次数: 0
Thank you, everyone 谢谢大家。
IF 2.3 Q3 Dentistry Pub Date : 2025-06-03 DOI: 10.1038/s41432-025-01156-1
Elizabeth Kay
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引用次数: 0
Management strategies for posterior deciduous and permanent teeth with developmental defects of enamel presenting post-eruptive breakdown or atypical cavitated carious lesions: systematic review and meta-analysis 后乳牙和恒牙釉质发育缺陷出现出牙后破裂或非典型空化龋齿的处理策略:系统回顾和荟萃分析。
IF 2.3 Q3 Dentistry Pub Date : 2025-05-30 DOI: 10.1038/s41432-025-01167-y
Aline Maquiné Pascareli-Carlos, Rayane Melo Ribeiro, Beatriz Tebalde Albuquerque Souza, Isabela Floriano, Michele Baffi Diniz, Sávio José Cardoso Bezerra, Erika Meneses Silva, Daniela Prócida Raggio, Tatiane Fernandes Novaes, Tamara Kerber Tedesco
This study aimed to evaluate different management strategies for treating posterior deciduous and permanent teeth affected by developmental defects of enamel (DDE) presenting with post-eruptive breakdown or atypical cavitated carious lesions, with a focus on longevity and the acceptability/perception of the treatment by parents and children. A comprehensive search of electronic databases was conducted up to April 09, 2025, to identify clinical studies addressing treatment approaches for posterior deciduous or permanent teeth with DDE in children up to 14 years old. Ninety studies met the inclusion criteria: 15 focused on molar-incisor hypomineralisation (MIH), one on hypomineralised second primary molar, one on amelogenesis imperfecta, and two covering various types of DDE. The most used restorative treatments included aesthetic and metal crowns, composite resin (CR) and glass ionomer cement (GIC) restorations, and indirect restoration with composite resin (ICR) and ceramics (ICeramics), which have been well accepted by both parents and children. Meta-analyses were conducted exclusively on studies related to MIH. Over a 24-month follow-up period, the overall success rate was 84% (95% CI: 70–99%). Subgroup analyses did not indicate significant differences among restorative treatment options (p = 0.336). Aesthetic and metal crowns, ICR, ICeramics, CR, and GIC may be viable treatment options for the management of MIH and other types of DDE. However, the certainty of the evidence remains low, and most studies exhibited a high or critical risk of bias.
目的:本研究旨在评估治疗后乳牙和恒牙釉质发育缺陷(DDE)的不同治疗策略,这些缺陷表现为爆发后破裂或非典型空化龋齿病变,重点是治疗的寿命和父母和儿童对治疗的可接受性/感知。方法:对截至2025年4月9日的电子数据库进行全面检索,以确定14岁以下儿童后乳牙或恒牙DDE治疗方法的临床研究。结果:90项研究符合纳入标准:15项研究集中在磨牙-切牙低矿化(MIH), 1项研究集中在第二初级磨牙低矿化,1项研究集中在釉质发育不全,2项研究涵盖各种类型的DDE。最常用的修复方法包括美学修复和金属冠修复、复合树脂(CR)和玻璃离子水泥(GIC)修复以及复合树脂(ICR)和陶瓷(ICeramics)的间接修复,这些方法已被家长和儿童广泛接受。荟萃分析仅针对与MIH相关的研究。在24个月的随访期间,总成功率为84% (95% CI: 70-99%)。亚组分析没有显示恢复性治疗方案之间的显著差异(p = 0.336)。结论:美冠和金属冠、ICR、ICeramics、CR和GIC可能是治疗MIH和其他类型DDE的可行选择。然而,证据的确定性仍然很低,大多数研究显示出高度或严重的偏倚风险。
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引用次数: 0
The association between maternal smoking during pregnancy and dental development in offspring: a systematic review 怀孕期间母亲吸烟与后代牙齿发育之间的关系:一项系统综述。
IF 2.3 Q3 Dentistry Pub Date : 2025-05-29 DOI: 10.1038/s41432-025-01168-x
Harry Tiernan, Muhammad Masud, Sawyer Lange, Shanika Nanayakkara, Thilini N. Jayasinghe
To investigate the effect of maternal smoking during pregnancy (MSDP) on the development of dental conditions in human offspring, as presented in current literature. Observational studies from six databases (MEDLINE, Embase, CINAHL, Scopus, Web of Science and Maternity and Infant Care (MIC)) were systematically searched in July 2024. Articles were screened based on their investigation of the effect of MSDP on the development of dental conditions in offspring. Methodological quality was assessed using the Newcastle Ottawa Scale (NOS), while the quality of evidence was evaluated using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. A total of 17 articles were included in this review, focusing on the primary dental developmental outcomes: molar incisor hypomineralisation (MIH), enamel defects (other than MIH), missing teeth, dental eruption, and short root anomaly. Due to high levels of heterogeneity among the studies, meta-analysis was not performed. The majority of studies demonstrated good methodological quality (n = 10), with three assessed as fair and four as poor. The quality of evidence was categorised, with three outcomes receiving a low quality of evidence classification, and tooth eruption and short root anomaly being classed as very low quality. Statistically significant associations between MSDP and each dental outcome had varied results across studies. Most studies concluded an association between MSDP and conditions such as enamel defects (other than MIH), missing teeth, and short root anomaly. Some studies found associations with MIH, while the majority found no link between MSDP and tooth eruption in offspring. This review suggests a potential association between MSDP and dental development conditions in offspring. However, due to the low quality of evidence and inconsistencies in findings across observational studies, a definitive association cannot be drawn. Further, novel and high-quality research is needed to understand the impact MSDP on dental development in offspring.
目的:根据目前的文献,探讨孕期吸烟对人类后代牙齿状况发展的影响。方法:系统检索2024年7月MEDLINE、Embase、CINAHL、Scopus、Web of Science和妇幼保健(MIC) 6个数据库中的观察性研究。文章的筛选是基于他们对MSDP对后代牙齿状况发展的影响的调查。方法质量采用纽卡斯尔渥太华量表(NOS)进行评估,证据质量采用建议、评估、发展和评估分级(GRADE)方法进行评估。结果:本综述共纳入17篇文章,重点关注初级牙齿发育结局:磨牙切牙低矿化(MIH)、牙釉质缺陷(MIH除外)、缺牙、牙萌出和短根异常。由于研究之间存在高度异质性,因此未进行meta分析。大多数研究显示出良好的方法学质量(n = 10),其中3项被评估为一般,4项被评估为较差。对证据质量进行了分类,其中三个结果为低质量证据分类,牙齿萌出和短根异常为极低质量证据分类。在不同的研究中,MSDP与每一种牙齿预后之间的统计学显著关联有不同的结果。大多数研究认为MSDP与牙釉质缺损(MIH除外)、缺牙和短根异常等情况有关。一些研究发现与MIH有关,而大多数研究发现MSDP与后代的牙齿萌出之间没有联系。结论:本综述提示MSDP与后代牙齿发育状况之间的潜在关联。然而,由于证据质量低和观察性研究结果不一致,无法得出明确的关联。此外,需要新颖和高质量的研究来了解MSDP对后代牙齿发育的影响。
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引用次数: 0
Which management strategy has the highest success rate for occlusoproximal caries lesions in primary molars? A systematic review and network meta-analysis 第一磨牙近端牙合龋齿,哪种治疗策略成功率最高?系统回顾和网络荟萃分析。
IF 2.3 Q3 Dentistry Pub Date : 2025-05-29 DOI: 10.1038/s41432-025-01164-1
Jonathan Rafael Garbim, Livia da Rosa Oliveira, Rodolfo de Carvalho Oliveira, Tamara Kerber Tedesco, Daniela Prócida Raggio
Managing occlusoproximal lesions remains a challenge for dental professionals. The aim of this systematic review was to identify the best strategy to treat occlusoproximal caries lesions in primary molars. A systematic search was conducted in MEDLINE/PubMed, Web of Science, Scopus, EMBASE, and ProQuest up to 7th February 2024. Randomized controlled trials comparing different management strategies for occlusoproximal caries lesions with at least 12 months of follow-up were included. Network meta-analyses were carried out considering the success rate of the treatments as the outcome. Risk of bias was assessed using the RoB 2 tool, and the certainty of evidence with the GRADE tool. Seven studies were included, evaluating five treatment modalities: Hall Technique (HT), non-restorative cavity control (NRCC), conventional restorative treatment (CRT), silver diamine fluoride application (SDF), and Atraumatic Restorative Treatment (ART). HT had the highest success rate (80.8%). There was no statistical difference between other strategies. Only two studies showed a low risk of bias; the others had a high risk, primarily due to selective reporting bias. The HT had the highest success rate at 80.8%, making it the most effective treatment for occlusoproximal caries in primary molars. However, no significant difference was found between other treatment strategies. The certainty of evidence is limited by the high risk of bias, particularly selective reporting bias. Future research should also consider factors like patient preference and cost-effectiveness to better assess treatments in a patient-centered context. HT is the most effective option for managing occlusoproximal caries in primary molars in terms of success rate. However, the evidence is based on studies with a high risk of bias, and the certainty of evidence ranges from very low to moderate. CRD42021281085
目的:处理咬合近端病变仍然是牙科专业人员的挑战。本系统综述的目的是确定治疗初生磨牙近端牙合龋齿的最佳策略。方法:系统检索截至2024年2月7日的MEDLINE/PubMed、Web of Science、Scopus、EMBASE和ProQuest数据库。随机对照试验比较了至少12个月随访的牙合近端龋齿病变的不同治疗策略。以治疗成功率为结果,进行网络荟萃分析。使用RoB 2工具评估偏倚风险,使用GRADE工具评估证据的确定性。结果:纳入7项研究,评估了5种治疗方式:霍尔技术(HT)、非恢复性空腔控制(NRCC)、常规修复治疗(CRT)、氟化二胺银(SDF)和非创伤性修复治疗(ART)。HT手术成功率最高(80.8%)。其他策略之间没有统计学差异。只有两项研究显示低偏倚风险;其他人的风险较高,主要是由于选择性报告偏差。讨论:HT的成功率最高,达80.8%,是治疗初生磨牙近端牙合龋最有效的方法。然而,其他治疗策略之间没有显著差异。证据的确定性受到高偏倚风险的限制,特别是选择性报告偏倚。未来的研究还应考虑患者偏好和成本效益等因素,以更好地评估以患者为中心的治疗方法。结论:从成功率来看,HT是治疗磨牙近端牙合龋最有效的方法。然而,这些证据是基于具有高偏倚风险的研究,证据的确定性范围从非常低到中等。普洛斯彼罗:CRD42021281085。
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引用次数: 0
Dentures and the oral microbiome: Unraveling the hidden impact on edentulous and partially edentulous patients - a systematic review and meta-analysis 假牙和口腔微生物组:揭示对无牙和部分无牙患者的潜在影响-一项系统综述和荟萃分析。
IF 2.3 Q3 Dentistry Pub Date : 2025-05-29 DOI: 10.1038/s41432-025-01149-0
Seenivasan Madhan Kumar, Shanmuganathan Natarajan, Sridharan KS, Senthil Kumar Sundarajan, Parthasarathy Natarajan, A. Selva Arockiam
This systematic review and meta-analysis evaluate the impact of edentulism and denture use on the oral microbiome, focusing on microbial diversity, colonization and biofilm formation in completely and partially edentulous patients. A comprehensive search was conducted across five databases (PubMed-Medline, Scopus, Embase, Lilacs, and Google Scholar) until June 1, 2024. Randomized and non-randomized clinical trials, observational studies, and cohort studies were included. Data extraction and risk of bias assessment followed PRISMA guidelines. Meta-analysis was performed using STATA and R software with a random effects maximum likelihood model. Microbial co-occurrence networks, heatmaps, and longitudinal trends were analyzed, with heterogeneity assessed using Higgin’s I² (substantial heterogeneity defined as I² > 50%). Thirty-two studies met the inclusion criteria. The oral microbiome in edentulous patients differed significantly from dentate individuals, influenced by denture materials, design, and time. Veillonella abundance in acrylic complete dentures was 13.63% (95% CI = -0.04, 27.29), I² = 90.98%, compared to 49.10% (95% CI = -29.62, 115.81), I² = 99.47% in dentate patients. Candida albicans increased over time in acrylic dentures, from 63.13% (95% CI = 48.93, 77.33), I² = 99.84% after insertion to 344.72 CFU/ml × 10² (95% CI = 139.19, 550.24), I² = 98.30% at nine months. Streptococcus mutans in CAD/CAM dentures increased from 45.54 CFU/ml × 10² (95% CI = 33.82, 57.25), I² = 87.26% at three months to 125.22 CFU/ml × 10² (95% CI = 38.25, 212.18), I² = 97.89% at nine months. Co-occurrence networks revealed strong Candida albicans–Streptococcus mutans synergy, while Fusobacterium nucleatum showed antagonistic interactions. Heatmaps demonstrated microbial dysbiosis in denture stomatitis cases, with increased Porphyromonas gingivalis and Candida albicans and reduced commensals. Longitudinal analyses highlighted the progressive dominance of opportunistic pathogens, emphasizing the need for early and consistent hygiene interventions. Denture wearers exhibit distinct microbial communities influenced by biofilm formation, denture materials, and hygiene practices. Findings highlight the importance of antimicrobial denture materials and effective cleaning protocols in managing microbial colonization. Given high heterogeneity, standardized methodologies are essential for future research. Frequent professional cleaning and individualized hygiene strategies are necessary to prevent denture-associated infections and maintain oral health.
目的:本系统综述和荟萃分析评估全牙颌和义齿使用对口腔微生物组的影响,重点关注全牙颌和部分全牙颌患者的微生物多样性、定植和生物膜形成。方法:到2024年6月1日,对PubMed-Medline、Scopus、Embase、Lilacs和谷歌Scholar等5个数据库进行全面检索。包括随机和非随机临床试验、观察性研究和队列研究。数据提取和偏倚风险评估遵循PRISMA指南。meta分析采用STATA和R软件,采用随机效应最大似然模型。分析了微生物共生网络、热图和纵向趋势,并使用Higgin's I²(实质异质性定义为I²> 50%)评估异质性。结果:32项研究符合纳入标准。受义齿材料、设计和使用时间的影响,无牙患者的口腔微生物组与有牙个体存在显著差异。丙烯酸全口义齿患者的细孔菌丰度为13.63% (95% CI = -0.04, 27.29), I²= 90.98%,而正牙患者的细孔菌丰度为49.10% (95% CI = -29.62, 115.81), I²= 99.47%。假牙中白色念珠菌随时间增加,从插入后的63.13% (95% CI = 48.93, 77.33), I²= 99.84%增加到9个月时的344.72 CFU/ml × 10²(95% CI = 139.19, 550.24), I²= 98.30%。CAD/CAM义齿的变形链球菌从3个月时的45.54 CFU/ml × 10²(95% CI = 33.82, 57.25), I²= 87.26%增加到9个月时的125.22 CFU/ml × 10²(95% CI = 38.25, 212.18), I²= 97.89%。共生网络显示白色念珠菌-变形链球菌具有很强的协同作用,而核梭杆菌则表现出拮抗作用。热图显示,假牙口炎病例中微生物生态失调,牙龈卟啉单胞菌和白色念珠菌增加,共生菌减少。纵向分析强调了机会性病原体的逐渐优势,强调了早期和一致的卫生干预的必要性。结论:假牙佩戴者的微生物群落受生物膜形成、假牙材料和卫生习惯的影响。研究结果强调了抗菌义齿材料和有效清洁方案在管理微生物定植中的重要性。鉴于高度异质性,标准化方法对未来的研究至关重要。经常的专业清洁和个性化的卫生策略是预防假牙相关感染和维护口腔健康所必需的。
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引用次数: 0
Knowledge, attitudes and practices of orthodontists regarding orthodontic treatment of traumatized teeth: a systematic review 正畸医生对创伤牙齿正畸治疗的知识、态度和实践:系统回顾。
IF 2.3 Q3 Dentistry Pub Date : 2025-05-27 DOI: 10.1038/s41432-025-01166-z
Sukeshana Srivastav, Nitesh Tewari, Mohammad Atif, Gregory S. Antonarakis, Rabindra Man Shrestha, Partha Haldar
To assess the global status of the knowledge, attitudes, and practices of orthodontists regarding the orthodontic treatment of traumatized teeth. An a priori protocol was developed and registered (PROSPERO, CRD42022342038). The literature search based on the Population, Intervention, Comparator, and Outcome (PICO) elements of the research question was developed and conducted electronically in PubMed, LILACS, Web of Science, EMBASE, Scopus, and the Cochrane Library, up to 31st August 2024. Gray literature and reference searches were also performed. Titles and abstracts were screened, and later, full-text articles were identified. Data extraction and analysis were performed, and the risk of bias was analyzed via the Joanna Briggs Institute Critical Appraisal Checklist for cross-sectional analytical studies. The data was synthesized in form of tables and interpretation was performed. From a total of 1272 articles initially identified, six studies qualified for the final synthesis. The awareness of orthodontic treatment of teeth with root fractures, crown fractures, crown‒root fractures, mild and severe injury to the periodontium, and teeth managed by revascularization and root canal treatment was found to be less than 40% in most of the studies. Awareness regarding the risk of resorption in teeth with external inflammatory root resorption and avoiding forces on teeth with ankylosis was greater than 90%. The risk of bias was found to be low in three studies. The knowledge of orthodontists regarding most aspects of orthodontic management of traumatized teeth was found to be low or inadequate. There are wide variations in the protocols preferred, which differ from contemporary recommendations and evidence.
目的:评估全球正畸医生对创伤牙正畸治疗的知识、态度和实践状况。方法:制定并注册先验方案(PROSPERO, CRD42022342038)。基于研究问题的人口、干预、比较器和结果(PICO)元素的文献检索在PubMed、LILACS、Web of Science、EMBASE、Scopus和Cochrane Library中进行,截止到2024年8月31日。还进行了灰色文献和参考文献检索。筛选标题和摘要,然后确定全文文章。进行数据提取和分析,并通过横截面分析研究的乔安娜布里格斯研究所关键评估清单分析偏倚风险。数据以表格的形式合成,并进行解释。结果:从最初鉴定的1272篇文章中,有6篇研究符合最终合成条件。在大多数研究中,对牙根骨折、牙冠骨折、牙冠-牙根骨折、牙周膜轻、重度损伤以及采用血管重建和根管治疗的牙齿的正畸治疗的知知率低于40%。对外炎症性牙根吸收的牙齿吸收风险的认识和避免对强直牙齿施加力的认识大于90%。三项研究发现偏倚风险较低。结论:正畸医师对创伤牙正畸治疗的大多数方面的知识水平较低或不足。不同于当前的建议和证据,首选的方案有很大的差异。
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引用次数: 0
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Evidence-based dentistry
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