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[The antioxidant properties of parmidine in a toxic lesion of the liver]. [帕米胺在肝脏毒性病变中的抗氧化特性]。
Pub Date : 1991-11-01
A N Riabkov, D G Uzbekova, G B Artem'eva, A A Nikulin

The experiments on rats with toxic lesions of the liver induced by tetrachlorinemethane showed that parmidine (pyridinolcarbamat) promotes the reduction of the activity of lipid peroxidation in the liver tissue homogenates and erythrocytes. The pronounced tendency towards normalization of free-radical oxidation correlated with the positive dynamics of the histological picture of the liver.

对四氯甲烷致肝毒性损伤大鼠的实验表明,帕米啶(吡啶氨基脲)可促进肝组织匀浆和红细胞脂质过氧化活性的降低。自由基氧化正常化的明显趋势与肝脏组织学图像的积极动态相关。
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引用次数: 0
[An analysis of the age-related characteristics of the analgesic action of clofelin]. [clofelin镇痛作用的年龄相关性分析]。
Pub Date : 1991-11-01
E T Zlenko, E M Demchenko

In the experiments on rats of different ages it was found that the analgesic effect of clopheline was stronger in the adult animals as compared with 1-month-old ones. Against the background of the operative trauma (laparotomy) the inversion of the effect occurs, namely clopheline exerts a more potent analgesic effect of clopheline in young animals. Simultaneously in the young animals there is observed suppression of the memory processes based on the nociceptive reinforcement. The potentiation of the analgesic effect of clopheline in 1-month-old animals is followed by an increase of the activity of Na+, K(+)-ATPase in the brain cortex the degree of which (two times) corresponds to the rise of the analgesic effect.

在不同年龄的大鼠实验中发现,与1月龄的大鼠相比,氯酚林对成年大鼠的镇痛作用更强。在手术创伤(开腹手术)的背景下,这种效应发生了反转,即在幼龄动物中,clopheline比clophine具有更强的镇痛作用。同时,在幼龄动物中,观察到基于伤害性强化的记忆过程受到抑制。氯酚林在1月龄大鼠的镇痛作用增强后,脑皮层内Na+, K(+)- atp酶活性增加,其程度(2倍)对应于镇痛作用的增强。
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引用次数: 0
[The pharmacology of non-narcotic analgesics]. [非麻醉性镇痛药的药理学]。
Pub Date : 1991-11-01
F P Trinus, T A Bukhtiarova
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引用次数: 0
[The effect of GABA-ergic agents on oxidative phosphorylation in the brain mitochondria in traumatic edema]. [gaba能药物对创伤性水肿脑线粒体氧化磷酸化的影响]。
Pub Date : 1991-11-01
V E Novikov, A n Sharov

The condition of oxidative phosphorylation in the rat brain mitochondria was studied polarographically in dynamics of the brain traumatic edema. It was found that 24 hours after the trauma the rate of oxidation in mitochondria decreased and the degree of conjugation in the respiratory chain compensatorily increased. Piracetam (1 g/kg), phenibut (50 mg/kg) and to a lesser degree sodium oxybutyrate (0.2 g/kg) prevented the 'changes and enhanced the compensatory capacities of mitochondria during the development of traumatic edema of the brain.

用极谱法研究了大鼠脑创伤性水肿过程中线粒体氧化磷酸化的动态变化。结果发现,损伤后24小时线粒体氧化速率降低,呼吸链的结合度代偿性增加。吡拉西坦(1g /kg)、苯乙酯(50mg /kg)和氧丁酸钠(0.2 g/kg)在较小程度上阻止了线粒体在脑创伤性水肿发展过程中的变化,并增强了线粒体的代偿能力。
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引用次数: 0
[Stimulants of the pentose pathway of glucose oxidation as protective agents in renal ischemia]. [葡萄糖氧化戊糖通路的兴奋剂作为肾缺血的保护剂]。
Pub Date : 1991-09-01
N D Vorob'eva, G D Anikin
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引用次数: 0
[The characteristics of the embryotoxic action of kalipsol]. 【卡利普索尔胚胎毒性作用的特点】。
Pub Date : 1991-09-01
Iu I Bandazhevskiĭ, A I Shimanovich

The effect of calipsol on the course of pregnancy and the embryonal development in albino rats was studied. It was found that single injections of the drug in a dose of 200 mg/kg on the 7th or 8th day of pregnancy induced no disorders in the pregnancy course and the embryonal development. At the administration in a dose of 40.0 mg/kg on the 11th, 13th, 15th days of pregnancy calipsol was shown to exert a marked embryolethal action and at the administration on the 7th, 9th, 11th days of pregnancy in doses of 20 and 40 mg/kg increased the number of fetuses with hemorrhages into the internal organs.

研究了卡利普索尔对白化大鼠妊娠过程及胚胎发育的影响。在妊娠第7天或第8天单次注射剂量为200 mg/kg的药物对妊娠过程和胚胎发育无影响。在妊娠第11、13、15天给药剂量为40.0 mg/kg时,显示出明显的胚胎死亡作用,在妊娠第7、9、11天给药剂量为20和40 mg/kg时,内脏出血的胎儿数量增加。
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引用次数: 0
[The effect of nitrosorbide, korinfar and obzidan on the hemodynamics of patients with chronic hepatitis and liver cirrhosis based on the data acute drug trials]. [基于急性药物试验数据的亚硝基山梨酯、柯利法和奥比丹对慢性肝炎和肝硬化患者血流动力学的影响]。
Pub Date : 1991-09-01
L P Vorob'ev, I V Maev

The data obtained during the complex clinical and instrumental investigation of the hemodynamics in patients with the syndrome of portal and pulmonary hypertension against the background of acute drug tests with nitrosorbide, corinfar and obsidan, are presented. By using modern ultrasound and rheographic techniques, the degree and the relationship of portal and pulmonary hypertensions in patients with chronic hepatitis and cirrhosis of the liver are evaluated, the criteria of their early diagnosis are characterized. There was shown a positive action on the renal blood flow of nitrosorbide, an improvement of the pulmonary hemodynamics in patients with diseases of the liver against the background of corinfar exerting no influence on the hepatic blood flow. Obsidan induced a significant decrease of both portal and pulmonary hypertensions, normalization of the total hemodynamics thereby producing the greatest positive effect.

在复杂的临床和仪器调查中获得的数据,在门静脉和肺动脉高压综合征患者的血液动力学的背景下,急性药物试验与亚硝基山药,哥尔法和奥比丹,提出。应用现代超声和血流造影技术,评价慢性肝炎肝硬化患者门静脉高压和肺动脉高压的程度及其相互关系,探讨其早期诊断标准。亚硝基山梨碱对肾血流有积极作用,可改善肝硬化患者肺血流动力学,但对肝血流无影响。奥比旦诱导门脉高压和肺动脉高压显著降低,使总血流动力学正常化,从而产生最大的积极作用。
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引用次数: 0
[Digoxin--an active antiepileptic agent]. 地高辛——一种有效的抗癫痫药。
Pub Date : 1991-09-01
I V Markova, I B Mikhaĭlov, V I Guzeva

A new pathogenetically grounded approach to the treatment of resistant forms of epilepsy is proposed. Digoxin suppresses the activity of experimental epileptogenic foci produced in the hippocampus of animals (frogs and rats) and also convulsions induced by corazol, bemegrid or electroshock. The antiepileptic and anticonvulsant activity of the drug was confirmed during its clinical testing on 20 children with grave forms of epilepsy which were resistant to the known antiepileptic drugs. The positive therapeutic effect was obtained in 42% of the cases.

提出了一种新的基于病理学的治疗顽固性癫痫的方法。地高辛抑制动物(青蛙和大鼠)海马中实验性致痫灶的活动,也抑制由科拉唑、贝美格或电击引起的抽搐。通过对20例对已知抗癫痫药物有耐药性的严重癫痫患儿的临床试验,证实了该药的抗癫痫和抗惊厥活性。42%的病例获得了积极的治疗效果。
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引用次数: 0
[The evaluation of the efficacy of carbamazepine and valproic acid in the alcohol postintoxication syndrome based on ethanol and acetaldehyde kinetics and the content of biogenic monoamines]. [基于乙醇和乙醛动力学及生物源性单胺含量评价卡马西平和丙戊酸治疗酒精中毒后综合征的疗效]。
Pub Date : 1991-09-01
L V Mitina, A L Khokhlov

The effects of carbamazepine and valproic acid on disturbances of behaviour, elimination of ethanol, acetaldehyde from the blood, the contents of adrenaline, noradrenaline, dopamine, serotonin, 5-hydroxyindoleacetic acid and histamine in the brain and blood in alcoholic postintoxication syndrome were studied on male albino rats. Carbamazepine and valproic acid were shown to reduce the behavioural manifestations of the syndrome, to increase elimination of ethanol and acetaldehyde, to normalize the levels of the mediators in the brain tissues, particularly in the thalamus.

研究了卡马西平和丙戊酸对雄性白化大鼠酒精中毒后综合征的行为障碍、血液中乙醇、乙醛的消除、肾上腺素、去甲肾上腺素、多巴胺、血清素、5-羟基吲哚乙酸和组胺含量的影响。卡马西平和丙戊酸被证明可以减少综合症的行为表现,增加乙醇和乙醛的消除,使脑组织中介质的水平正常化,特别是在丘脑中。
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引用次数: 0
[The combined use of acupuncture and antidepressants for managing the spondylogenic lumbosacral pain syndrome]. [联合使用针灸和抗抑郁药治疗腰椎源性疼痛综合征]。
Pub Date : 1991-09-01
A V Amelin, Iu N Vasil'ev, Iu D Ignatov, A A Skoromets

The effects of antidepressants amitriptyline and pyrazidol on the analgesic action of acupuncture in patients with lumbosacral radiculitis was studied by the double blind control method. The combined use of acupuncture with antidepressants was shown to enhance the effectiveness of the treatment, to increase on the average by 5-6 hours the duration of analgesia within 24 hours after each procedure, to reduce the duration of the treatment on the average by 4-5 days, that indicates the expediency of clinical use of the proposed combination.

采用双盲对照法研究抗抑郁药阿米替林和吡嗪醇对针刺治疗腰骶神经根炎患者镇痛作用的影响。针灸与抗抑郁药联合使用可提高治疗效果,每次手术后24小时内镇痛时间平均增加5-6小时,治疗时间平均减少4-5天,表明所建议的组合在临床应用的方便性。
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引用次数: 0
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Farmakologiia i toksikologiia
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