{"title":"Circulating Type 2 Memory B Cell Frequency Is a Biomarker for Allergen Immunotherapy Efficacy in Patients With Allergic Rhinitis.","authors":"Yue Ma,Shuying Li,Lei Ye,Lin Qiu,Jiayu Wu,Jiaying Li,Xian Feng,Wei Qian,Xiangping Yang,Huabin Li,Hongfei Lou","doi":"10.1111/all.70221","DOIUrl":"https://doi.org/10.1111/all.70221","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"42 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qingqing Xu, Yang Sun, Carmen Messerlian, Chenyin Dong, Yu Zhang, Vicente Mustieles, Chong Liu, Keyi Si, Jun Liu, Yunjiang Yu, Yi‐Xin Wang
{"title":"Association Between Fluoride Exposure and Asthma Among US Children and Adolescents","authors":"Qingqing Xu, Yang Sun, Carmen Messerlian, Chenyin Dong, Yu Zhang, Vicente Mustieles, Chong Liu, Keyi Si, Jun Liu, Yunjiang Yu, Yi‐Xin Wang","doi":"10.1111/all.70214","DOIUrl":"https://doi.org/10.1111/all.70214","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"5 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Portacci,Remo Poto,Gilda Varricchi,Giovanna Elisiana Carpagnano
{"title":"Reply to \"Dupilumab-Induced Blood Eosinophilia-Why We Need to Look Beyond the Blood\".","authors":"Andrea Portacci,Remo Poto,Gilda Varricchi,Giovanna Elisiana Carpagnano","doi":"10.1111/all.70220","DOIUrl":"https://doi.org/10.1111/all.70220","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"29 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145968352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pavel Kolkhir,Pascale Salameh,Magdalena Zajac,Alicja Kasperska-Zajac,Ana Giménez-Arnau,Maria Puertolas,Hanna Bonnekoh,Carolina Vera Ayala,Michael Makris,Eleni Chatzidimitriou,Stamatios Gregoriou,Kanokvalai Kulthanan,Andrea Bauer,Mojca Bizjak-Suran,Daria Fomina,Alexis Bocquet,Joachim Dissemond,Mohamed Abuzakouk,Tara Raftery,Nadine Chapman-Rothe,Emek Kocatürk,Clive Grattan,Riccardo Asero,Jonny G Peter,Simon Francis Thomsen,Karsten Weller
BACKGROUNDMany patients with chronic spontaneous urticaria (CSU) remain symptomatic despite receiving second-generation H1-antihistamines (sgH1-AH). This data analysis from the Chronic Urticaria Registry (CURE) aimed to describe treatment patterns and identify unmet needs in real-world practice.METHODSCURE is an international, prospective registry of patients with chronic urticaria. Treatment responses were categorized as Urticaria Control Test (UCT) changes from baseline (BL) to 6-month follow-up (FU). Complete response was defined as UCT = 16 with a ≥ 3-point increase.RESULTSData were available from 3995 adult patients with CSU at BL and 1288 at FU with evaluable UCT. After treatment escalation from BL to FU, 5.3% (no treatment to licensed-dose sgH1-AH), 6.0% (licensed-dose sgH1-AH to up-dosed sgH1-AH), and 28.4% (any dose sgH1-AH to omalizumab) achieved complete response. Factors associated with a lower probability of treatment escalation at FU were UCT ≥ 12 and omalizumab treatment at BL (both p < 0.0001). About one-third (28.6%) of patients clinically eligible for escalation at BL (UCT < 12) did not receive step-up treatment (18.0%) or were even stepped down (10.6%) and remained poorly controlled at FU. Factors associated with lack of escalation in this group included younger age (p = 0.014), shorter disease duration (p = 0.071), presence of wheals and angioedema (p = 0.002), better quality of life (p = 0.001), and treatment with up-dosed sgH1-AH (p = 0.031).CONCLUSIONAppropriate treatment escalation improves CSU control, although only about a quarter of patients achieve a complete response, indicating the need for novel treatments. Many patients with poorly controlled CSU do not receive guideline-recommended treatment escalation and remain symptomatic on their current treatments, which deserves further attention.
{"title":"Unmet Needs in Treatment Escalation for Chronic Spontaneous Urticaria: Findings From the CURE Registry.","authors":"Pavel Kolkhir,Pascale Salameh,Magdalena Zajac,Alicja Kasperska-Zajac,Ana Giménez-Arnau,Maria Puertolas,Hanna Bonnekoh,Carolina Vera Ayala,Michael Makris,Eleni Chatzidimitriou,Stamatios Gregoriou,Kanokvalai Kulthanan,Andrea Bauer,Mojca Bizjak-Suran,Daria Fomina,Alexis Bocquet,Joachim Dissemond,Mohamed Abuzakouk,Tara Raftery,Nadine Chapman-Rothe,Emek Kocatürk,Clive Grattan,Riccardo Asero,Jonny G Peter,Simon Francis Thomsen,Karsten Weller","doi":"10.1111/all.70199","DOIUrl":"https://doi.org/10.1111/all.70199","url":null,"abstract":"BACKGROUNDMany patients with chronic spontaneous urticaria (CSU) remain symptomatic despite receiving second-generation H1-antihistamines (sgH1-AH). This data analysis from the Chronic Urticaria Registry (CURE) aimed to describe treatment patterns and identify unmet needs in real-world practice.METHODSCURE is an international, prospective registry of patients with chronic urticaria. Treatment responses were categorized as Urticaria Control Test (UCT) changes from baseline (BL) to 6-month follow-up (FU). Complete response was defined as UCT = 16 with a ≥ 3-point increase.RESULTSData were available from 3995 adult patients with CSU at BL and 1288 at FU with evaluable UCT. After treatment escalation from BL to FU, 5.3% (no treatment to licensed-dose sgH1-AH), 6.0% (licensed-dose sgH1-AH to up-dosed sgH1-AH), and 28.4% (any dose sgH1-AH to omalizumab) achieved complete response. Factors associated with a lower probability of treatment escalation at FU were UCT ≥ 12 and omalizumab treatment at BL (both p < 0.0001). About one-third (28.6%) of patients clinically eligible for escalation at BL (UCT < 12) did not receive step-up treatment (18.0%) or were even stepped down (10.6%) and remained poorly controlled at FU. Factors associated with lack of escalation in this group included younger age (p = 0.014), shorter disease duration (p = 0.071), presence of wheals and angioedema (p = 0.002), better quality of life (p = 0.001), and treatment with up-dosed sgH1-AH (p = 0.031).CONCLUSIONAppropriate treatment escalation improves CSU control, although only about a quarter of patients achieve a complete response, indicating the need for novel treatments. Many patients with poorly controlled CSU do not receive guideline-recommended treatment escalation and remain symptomatic on their current treatments, which deserves further attention.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"4 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145961275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Allergic Rhinitis in China Continues to Increase Without Reaching a Plateau: An Analysis of Three Waves of National Surveys From 2005 to 2019.","authors":"Xiaoyu Pu,Ming Zheng,Siqi Ge,Yutong Sima,Xiaoru Yu,Zhongyi Wang,Xiangdong Wang,Luo Zhang","doi":"10.1111/all.70216","DOIUrl":"https://doi.org/10.1111/all.70216","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"9 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145956021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yanan He, Dan Ye, Jiahua Guo, Weihui Zeng, Zhao Wang
{"title":"Murine Model of Chronic Spontaneous Urticaria‐Like Skin","authors":"Yanan He, Dan Ye, Jiahua Guo, Weihui Zeng, Zhao Wang","doi":"10.1111/all.70211","DOIUrl":"https://doi.org/10.1111/all.70211","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"37 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145920060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sofia Papavasileiou,Jiezhen Mo,Daryl Boey,Chenyan Wu,Magnus Tronstad,Lucille Margerie,Remi-André Olsen,Jörg A Bachmann,Jing Hui Low,Jocelyn Ong,Lars Heede Blom,Anand Kumar Andiappan,Gunnar Nilsson,Joakim S Dahlin
BACKGROUNDBasophils are implicated in various diseases including allergies, but a comprehensive single-cell characterization of human basophils has yet to be performed. Here, we aimed to generate a single-cell omics-based reference resource of circulating human basophils, integrating transcriptomic and large-scale immunoprofiling data. We also sought to investigate basophil heterogeneity at the molecular level.METHODSCirculating basophils were analyzed using cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq). Both short- and long-read single-cell RNA-sequencing platforms were used to capture the transcriptomic data.RESULTSCITE-seq enabled accurate identification and profiling of side scatterlow lineage- CCR3+ FcεRI+ basophils. Short-read single-cell RNA-sequencing data revealed two previously unresolved basophil populations, defined by 66 differentially expressed genes and reproducibly identified across donors. Despite the transcriptional differences, the populations displayed similar immunophenotypes based on more than 100 investigated cell surface markers. Long-read single-cell RNA-sequencing analysis confirmed the existence of the two populations and provided further insights into their gene expression profiles.CONCLUSIONSWe present a multimodal single-cell resource that defines two novel transcriptionally distinct basophil populations. This resource, accessible through a user-friendly web interface, constitutes a cellular and molecular reference map for future studies of basophils in health and disease.
{"title":"Single-Cell Omics Analysis of Human Basophils Reveals Two Transcriptionally Distinct Populations.","authors":"Sofia Papavasileiou,Jiezhen Mo,Daryl Boey,Chenyan Wu,Magnus Tronstad,Lucille Margerie,Remi-André Olsen,Jörg A Bachmann,Jing Hui Low,Jocelyn Ong,Lars Heede Blom,Anand Kumar Andiappan,Gunnar Nilsson,Joakim S Dahlin","doi":"10.1111/all.70209","DOIUrl":"https://doi.org/10.1111/all.70209","url":null,"abstract":"BACKGROUNDBasophils are implicated in various diseases including allergies, but a comprehensive single-cell characterization of human basophils has yet to be performed. Here, we aimed to generate a single-cell omics-based reference resource of circulating human basophils, integrating transcriptomic and large-scale immunoprofiling data. We also sought to investigate basophil heterogeneity at the molecular level.METHODSCirculating basophils were analyzed using cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq). Both short- and long-read single-cell RNA-sequencing platforms were used to capture the transcriptomic data.RESULTSCITE-seq enabled accurate identification and profiling of side scatterlow lineage- CCR3+ FcεRI+ basophils. Short-read single-cell RNA-sequencing data revealed two previously unresolved basophil populations, defined by 66 differentially expressed genes and reproducibly identified across donors. Despite the transcriptional differences, the populations displayed similar immunophenotypes based on more than 100 investigated cell surface markers. Long-read single-cell RNA-sequencing analysis confirmed the existence of the two populations and provided further insights into their gene expression profiles.CONCLUSIONSWe present a multimodal single-cell resource that defines two novel transcriptionally distinct basophil populations. This resource, accessible through a user-friendly web interface, constitutes a cellular and molecular reference map for future studies of basophils in health and disease.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"84 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Casey G. Cohen, Diana Toscano‐Rivero, Eisha A. Ahmed, Adnan Al Ali, Wei Zhao, Danbing Ke, Duncan Lejtenyi, Liane Beaudette, Hana Chazbey, Abdulaziz S. Alrafiaah, Carmen H. Li, Kurt Dejgaard, Albert M. Berghuis, Bertrand J. Jean‐Claude, Christine McCusker, Thomas Eiwegger, Moshe Ben‐Shoshan, Bruce D. Mazer
Background Major peanut allergens are stable and resistant to denaturation under standard cooking conditions, contributing to allergenicity and low rates of developing natural tolerance in allergic individuals. We evaluated the effects of heat and pressure autoclaving on peanut proteins, IgE binding, and oral tolerability. Methods Raw, roasted, and autoclaved peanut protein extracts were evaluated by Bradford assay, ELISA, and mass spectrometry‐proteomics to compare relative amounts of protein, specific IgE binding, and allergen fragmentation. To assess changes in clinical reactivity, we performed skin prick testing (SPT) in 41 subjects using standard and autoclaved peanut extracts. We also performed double‐blind oral food challenges (OFC) in 10 peanut‐allergic subjects with standard and autoclaved peanuts. Results Autoclaving at 130°C, 2.4 atm, for 30 min significantly degraded allergens Ara h 1 and 2, and completely degraded Ara h 8. Mass spectrometry‐proteomics analysis of size‐filtered extracts (< 10 kDa) showed greater numbers and diversity of peptides from peanut proteins and allergens in autoclaved extracts. Autoclaving fragmented proteins into shorter peptides, against which sera from highly allergic patients exhibited a 74% reduction in IgE binding compared to raw peanuts. SPT demonstrated significant decreases in wheal diameters using autoclaved peanut extract (median [IQR] = 5 mm [2, 9]) compared to commercial extract (10 mm [6, 15]; p < 0.001). All OFC subjects tolerated the maximum cumulative autoclaved peanut dose (444 mg) versus standard peanut (median: 9 mg, range: [1, 44]). Conclusions Autoclaving peanuts induces important chemical changes including fragmentation, leading to decreased peanut allergenicity and consequently increased tolerability. This has the potential for novel immunotherapeutic approaches with more favorable side effect profiles.
主要的花生过敏原在标准烹饪条件下是稳定的和耐变性的，这有助于过敏个体的致敏性和低自然耐受性。我们评估了高温高压灭菌对花生蛋白、IgE结合和口服耐受性的影响。方法采用Bradford法、ELISA法和质谱-蛋白质组学方法对生的、烘烤的和高压灭菌的花生蛋白提取物进行评价，比较蛋白质的相对量、特异性IgE结合和过敏原碎片。为了评估临床反应性的变化，我们对41名受试者进行了皮肤点刺试验（SPT），使用标准和高压灭菌的花生提取物。我们还对10名花生过敏受试者进行了双盲口服食物挑战（OFC），分别使用标准花生和蒸压花生。结果130℃、2.4 atm高压灭菌30 min后，过敏原Ara h 1和Ara h 2明显降解，Ara h 8完全降解。质谱-蛋白质组学分析尺寸过滤提取物（< 10 kDa）显示，高压灭菌提取物中花生蛋白和过敏原肽的数量和多样性更高。用高压灭菌法将蛋白质碎片化成更短的肽，与生花生相比，高度过敏患者的血清中IgE结合减少了74%。SPT显示，与商业提取物（10 mm [6,15]; p < 0.001）相比，蒸压花生提取物的轮径显著降低（中位数[IQR] = 5 mm[2,9]）。所有OFC受试者耐受最大累积蒸压花生剂量（444 mg）与标准花生（中位数：9 mg，范围：[1,44]）。结论高压灭菌花生可引起包括碎裂在内的重要化学变化，从而降低花生的致敏性，提高耐受性。这有可能开发出具有更有利副作用的新型免疫治疗方法。
{"title":"Autoclaved Peanuts Exhibit Reduced Immunoglobulin E Binding and Improved Oral Tolerability","authors":"Casey G. Cohen, Diana Toscano‐Rivero, Eisha A. Ahmed, Adnan Al Ali, Wei Zhao, Danbing Ke, Duncan Lejtenyi, Liane Beaudette, Hana Chazbey, Abdulaziz S. Alrafiaah, Carmen H. Li, Kurt Dejgaard, Albert M. Berghuis, Bertrand J. Jean‐Claude, Christine McCusker, Thomas Eiwegger, Moshe Ben‐Shoshan, Bruce D. Mazer","doi":"10.1111/all.70208","DOIUrl":"https://doi.org/10.1111/all.70208","url":null,"abstract":"Background Major peanut allergens are stable and resistant to denaturation under standard cooking conditions, contributing to allergenicity and low rates of developing natural tolerance in allergic individuals. We evaluated the effects of heat and pressure autoclaving on peanut proteins, IgE binding, and oral tolerability. Methods Raw, roasted, and autoclaved peanut protein extracts were evaluated by Bradford assay, ELISA, and mass spectrometry‐proteomics to compare relative amounts of protein, specific IgE binding, and allergen fragmentation. To assess changes in clinical reactivity, we performed skin prick testing (SPT) in 41 subjects using standard and autoclaved peanut extracts. We also performed double‐blind oral food challenges (OFC) in 10 peanut‐allergic subjects with standard and autoclaved peanuts. Results Autoclaving at 130°C, 2.4 atm, for 30 min significantly degraded allergens Ara h 1 and 2, and completely degraded Ara h 8. Mass spectrometry‐proteomics analysis of size‐filtered extracts (< 10 kDa) showed greater numbers and diversity of peptides from peanut proteins and allergens in autoclaved extracts. Autoclaving fragmented proteins into shorter peptides, against which sera from highly allergic patients exhibited a 74% reduction in IgE binding compared to raw peanuts. SPT demonstrated significant decreases in wheal diameters using autoclaved peanut extract (median [IQR] = 5 mm [2, 9]) compared to commercial extract (10 mm [6, 15]; <jats:italic>p</jats:italic> < 0.001). All OFC subjects tolerated the maximum cumulative autoclaved peanut dose (444 mg) versus standard peanut (median: 9 mg, range: [1, 44]). Conclusions Autoclaving peanuts induces important chemical changes including fragmentation, leading to decreased peanut allergenicity and consequently increased tolerability. This has the potential for novel immunotherapeutic approaches with more favorable side effect profiles.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"11 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145903655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gage O Leighton, Taylor M Cosey, Emmanuel R De Diavoukana, Isabelle R Lytle, Alexander C Y Foo, Lars C Pedersen, Scott A Gabel, Robert M Petrovich, Min Shi, Venu Aruva, Paige Creeks, Joyce J W Wong, Jian Zhang, R Stokes Peebles, Derek Croote, Scott A Smith, Geoffrey A Mueller
{"title":"Polymeric α-Hairpinin Allergens Induce a Functional Response via a Single Antibody.","authors":"Gage O Leighton, Taylor M Cosey, Emmanuel R De Diavoukana, Isabelle R Lytle, Alexander C Y Foo, Lars C Pedersen, Scott A Gabel, Robert M Petrovich, Min Shi, Venu Aruva, Paige Creeks, Joyce J W Wong, Jian Zhang, R Stokes Peebles, Derek Croote, Scott A Smith, Geoffrey A Mueller","doi":"10.1111/all.70201","DOIUrl":"10.1111/all.70201","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12758636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145877338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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