Sarah E. Ashley, Melanie Lloyd, Paxton Loke, Francesca Orsini, Adriana C. Lozinsky, Michael D. O'Sullivan, Patrick Quinn, Michael Gold, Mimi L. K. Tang
BackgroundRemission is the desired outcome following OIT as it allows individuals to discontinue treatment and eat the allergen freely. Early initiation of OIT in infants and toddlers has been embraced as an approach to increase the likelihood of remission. However, there is no high‐quality evidence supporting younger age as an independent factor driving remission; available studies are limited by small samples of younger subjects and lack of adjustment for confounding covariates, particularly peanut‐specific IgE (sIgE) levels which is closely correlated with age.MethodsThis study examined relationships between peanut sIgE and age at baseline and remission, in children aged 1–10 who completed 18 months of OIT in the PPOIT‐003 RCT (n = 162). Remission was defined as absence of clinical reactivity to peanut after 8 weeks of allergen avoidance/treatment discontinuation. Age and sIgE were examined as continuous variables in univariate and multivariate regression models.ResultsHigher peanut sIgE was consistently predictive of lower likelihood of remission, independent of age. In contrast, there was no independent association between age and remission after adjusting for baseline sIgE (OR 0.94 [0.79–1.12], p = 0.5).ConclusionsFindings do not support age as an independent predictor of remission following OIT. Additional studies examining safety and efficacy of OIT in infants and younger children are urgently needed, ahead of widespread adoption of early intervention.
{"title":"Allergen Specific IgE is a Stronger Predictor of Remission Following Peanut Oral Immunotherapy Than Age in Children Aged 1–10 Years","authors":"Sarah E. Ashley, Melanie Lloyd, Paxton Loke, Francesca Orsini, Adriana C. Lozinsky, Michael D. O'Sullivan, Patrick Quinn, Michael Gold, Mimi L. K. Tang","doi":"10.1111/all.16451","DOIUrl":"https://doi.org/10.1111/all.16451","url":null,"abstract":"BackgroundRemission is the desired outcome following OIT as it allows individuals to discontinue treatment and eat the allergen freely. Early initiation of OIT in infants and toddlers has been embraced as an approach to increase the likelihood of remission. However, there is no high‐quality evidence supporting younger age as an independent factor driving remission; available studies are limited by small samples of younger subjects and lack of adjustment for confounding covariates, particularly peanut‐specific IgE (sIgE) levels which is closely correlated with age.MethodsThis study examined relationships between peanut sIgE and age at baseline and remission, in children aged 1–10 who completed 18 months of OIT in the PPOIT‐003 RCT (<jats:italic>n</jats:italic> = 162). Remission was defined as absence of clinical reactivity to peanut after 8 weeks of allergen avoidance/treatment discontinuation. Age and sIgE were examined as continuous variables in univariate and multivariate regression models.ResultsHigher peanut sIgE was consistently predictive of lower likelihood of remission, independent of age. In contrast, there was no independent association between age and remission after adjusting for baseline sIgE (OR 0.94 [0.79–1.12], <jats:italic>p</jats:italic> = 0.5).ConclusionsFindings do not support age as an independent predictor of remission following OIT. Additional studies examining safety and efficacy of OIT in infants and younger children are urgently needed, ahead of widespread adoption of early intervention.","PeriodicalId":122,"journal":{"name":"Allergy","volume":"57 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Birch pollen (BP) interacts with airway epithelial cells to cause allergic sensitization and allergy in predisposed individuals. However, the basic mechanisms underlying the clinical effects are poorly understood. Changes in gene expression and cytokine secretion in nasal mucosal cells upon BP exposure were determined in BP-allergic and non-allergic individuals.
Methods: BP-allergic (n = 11) and non-allergic individuals (n = 12) participated in nasal provocations with saline and aqueous BP solution. Nasal scrapings and secretions were obtained at baseline and after BP provocation. Bulk RNA sequencing of the nasal scrapings was performed, and cytokines in nasal secretions were quantified.
Results: After BP challenge, we identified 160 differentially expressed genes (DEGs) in the nasal scrapings of allergic individuals and 44 in non-allergic individuals. DEGs encoding S100 proteins, keratins, small proline-rich repeat proteins, and cytokines were predominantly identified, with proinflammatory cytokine transcripts being upregulated only in the allergic cohort. The top canonical pathways in allergic individuals included granulocyte and agranulocyte adhesion and diapedesis, wound healing, IL-8 signaling, and IL-17-related pathways. Enriched pathways in allergic participants were associated with granulocyte chemotaxis, humoral cell responses, and IL-10, IL-4, and IL-13 signaling and were absent in non-allergic individuals. At baseline and after BP challenge, higher amounts of CCL17, CCL20, CCL26, IL-7, IL-16, and IL-33 were detected in nasal secretions of allergic compared to non-allergic individuals.
Conclusion: Our results highlight the activation of important cellular signaling pathways specific to BP-allergic individuals after BP exposure offering new perspectives for studying key players in BP allergy.
{"title":"Transcriptomic Profiles of the Nasal Mucosa Following Birch Pollen Provocation Differ Between Birch Pollen-Allergic and Non-Allergic Individuals.","authors":"Srinidhi Sudharson, Julia Eckl-Dorna, Anastasia Meshcheryakova, José Basílio, Sophia Derdak, Tanja Kalic, Nina Lengger, Nina Schweitzer, Diana Mechtcheriakova, Heimo Breiteneder, Christine Hafner","doi":"10.1111/all.16448","DOIUrl":"https://doi.org/10.1111/all.16448","url":null,"abstract":"<p><strong>Background: </strong>Birch pollen (BP) interacts with airway epithelial cells to cause allergic sensitization and allergy in predisposed individuals. However, the basic mechanisms underlying the clinical effects are poorly understood. Changes in gene expression and cytokine secretion in nasal mucosal cells upon BP exposure were determined in BP-allergic and non-allergic individuals.</p><p><strong>Methods: </strong>BP-allergic (n = 11) and non-allergic individuals (n = 12) participated in nasal provocations with saline and aqueous BP solution. Nasal scrapings and secretions were obtained at baseline and after BP provocation. Bulk RNA sequencing of the nasal scrapings was performed, and cytokines in nasal secretions were quantified.</p><p><strong>Results: </strong>After BP challenge, we identified 160 differentially expressed genes (DEGs) in the nasal scrapings of allergic individuals and 44 in non-allergic individuals. DEGs encoding S100 proteins, keratins, small proline-rich repeat proteins, and cytokines were predominantly identified, with proinflammatory cytokine transcripts being upregulated only in the allergic cohort. The top canonical pathways in allergic individuals included granulocyte and agranulocyte adhesion and diapedesis, wound healing, IL-8 signaling, and IL-17-related pathways. Enriched pathways in allergic participants were associated with granulocyte chemotaxis, humoral cell responses, and IL-10, IL-4, and IL-13 signaling and were absent in non-allergic individuals. At baseline and after BP challenge, higher amounts of CCL17, CCL20, CCL26, IL-7, IL-16, and IL-33 were detected in nasal secretions of allergic compared to non-allergic individuals.</p><p><strong>Conclusion: </strong>Our results highlight the activation of important cellular signaling pathways specific to BP-allergic individuals after BP exposure offering new perspectives for studying key players in BP allergy.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roza Khalmuratova, Yi Sook Kim, Dae Woo Kim, Hyun‐Woo Shin
{"title":"A Differentiated Epithelial Layer Graft Improves Fibrosis and Survival in Airway Stenosis via IL‐37","authors":"Roza Khalmuratova, Yi Sook Kim, Dae Woo Kim, Hyun‐Woo Shin","doi":"10.1111/all.16452","DOIUrl":"https://doi.org/10.1111/all.16452","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"17 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamed H. Shamji, Edwin H. Kim, Marta Vazquez‐Ortiz, Paul J. Turner, Janice A. Layhadi
{"title":"Allergen‐Specific B Cell Responses Following Desensitisation and Natural Tolerance to Cow's Milk Allergy","authors":"Mohamed H. Shamji, Edwin H. Kim, Marta Vazquez‐Ortiz, Paul J. Turner, Janice A. Layhadi","doi":"10.1111/all.16443","DOIUrl":"https://doi.org/10.1111/all.16443","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"1 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Girish Hiremath, Simona G. Codreanu, Stacy D. Sherrod, Regina Tyree, Hernan Correa, Yash Choksi, John A. McLean, Andrea Locke
{"title":"Salivary Metabolomic Signatures in Pediatric Eosinophilic Esophagitis","authors":"Girish Hiremath, Simona G. Codreanu, Stacy D. Sherrod, Regina Tyree, Hernan Correa, Yash Choksi, John A. McLean, Andrea Locke","doi":"10.1111/all.16450","DOIUrl":"https://doi.org/10.1111/all.16450","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"14 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephane Esnault, Ksenija Bernau, Heather L. Floerke, Arnaud Dendooven, Emeline Delaunay, Kimberly A. Dill‐McFarland, Matthew C. Altman, William W. Busse, Melissa A. Rosenkranz, Matthew C. Tattersall, Mats W. Johansson, Julien Labreuche, Delphine Beury, Shéhérazade Sebda, Frédéric Dezoteux, Baptiste Segard, Geoffrey Mortuaire, Delphine Staumont‐Sallé, Thomas Stoup, Cécile Chenivesse, Nathan Sandbo, Nizar N. Jarjour, Guillaume Lefèvre
{"title":"Oncostatin‐M Is Produced by Human Eosinophils and Expression Is Increased in Uncontrolled Severe Asthma","authors":"Stephane Esnault, Ksenija Bernau, Heather L. Floerke, Arnaud Dendooven, Emeline Delaunay, Kimberly A. Dill‐McFarland, Matthew C. Altman, William W. Busse, Melissa A. Rosenkranz, Matthew C. Tattersall, Mats W. Johansson, Julien Labreuche, Delphine Beury, Shéhérazade Sebda, Frédéric Dezoteux, Baptiste Segard, Geoffrey Mortuaire, Delphine Staumont‐Sallé, Thomas Stoup, Cécile Chenivesse, Nathan Sandbo, Nizar N. Jarjour, Guillaume Lefèvre","doi":"10.1111/all.16453","DOIUrl":"https://doi.org/10.1111/all.16453","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"52 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global Burden of Asthma and Atopic Dermatitis in 2021: A Systemic Analysis of the Global Burden of Disease Study 2021.","authors":"Hong Luo, Fuqiang Wen","doi":"10.1111/all.16449","DOIUrl":"https://doi.org/10.1111/all.16449","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Zaleska, Adrian Gajewski, Anna Dor-Wojnarowska, Anna Radlińska, Marta Rorat, Maciej Chałubiński
{"title":"IL-25 and Periostin Serum Concentrations May Be Associated With COVID-19 Severity and Recovery.","authors":"Anna Zaleska, Adrian Gajewski, Anna Dor-Wojnarowska, Anna Radlińska, Marta Rorat, Maciej Chałubiński","doi":"10.1111/all.16431","DOIUrl":"https://doi.org/10.1111/all.16431","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alain Michils, Maxime Hackx, Lucas Mlynarski, Amaryllis Haccuria, Silvia Perez-Bogerd, Andreï Malinovschi, Alain Van Muylem
{"title":"How FEV<sub>1</sub> Improvement Induced by Anti-IL-5 in Severe Type-2 Asthma Is Linked to Mucus Plugs Clearance.","authors":"Alain Michils, Maxime Hackx, Lucas Mlynarski, Amaryllis Haccuria, Silvia Perez-Bogerd, Andreï Malinovschi, Alain Van Muylem","doi":"10.1111/all.16441","DOIUrl":"https://doi.org/10.1111/all.16441","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Freeman, Magdalena Minnion, Paul H Lee, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Tom Wilkinson, Martin Feelisch
{"title":"Circulating Nitrite in Severe Asthma: Just Another Biomarker or Novel Treatment Target?","authors":"Anna Freeman, Magdalena Minnion, Paul H Lee, Hans Michael Haitchi, Ramesh Kurukulaaratchy, Tom Wilkinson, Martin Feelisch","doi":"10.1111/all.16435","DOIUrl":"https://doi.org/10.1111/all.16435","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142851675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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