Allergy最新文献

{"title":"Expansion of phenotypically modified type 2 memory B cells after allergen immunotherapy","authors":"Anouk von Borstel, Simone Reinwald, Pei M. Aui, Craig I. McKenzie, Nirupama Varese, P. Mark Hogarth, Mark Hew, Robyn E. O'Hehir, Menno C. van Zelm","doi":"10.1111/all.16320","DOIUrl":"https://doi.org/10.1111/all.16320","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"12 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Efficacy of eHealth monitoring in pediatric asthma","authors":"Casper E. W. Gijsen, Thijs R. P. Bogers, Jean W. M. Muris, Marieke W. P. van van Horck, Edward Dompeling","doi":"10.1111/all.16317","DOIUrl":"https://doi.org/10.1111/all.16317","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"74 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142231293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of an ELISA‐based in vitro test system to quantify the major honey bee venom allergen Api m 10 in crude bee venoms and therapy allergen products","authors":"Alisa Landgraf, Sascha Hein, Kathrin Elisabeth Paulus‐Tremel, Michelle Beatrice Wolff, Meike Arend, Ann‐Christine Junker, Daniel Strecker, Sascha Döring, Elke Völker, Thomas Holzhauser, Sandra Schmidt, Susanne Kaul, Stefan Schülke, Vera Mahler","doi":"10.1111/all.16313","DOIUrl":"https://doi.org/10.1111/all.16313","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"9 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of venom immunotherapy and sting challenge on HRQoL measured by venom‐allergy quality of life questionnaire (VQLQ) in Jack jumper ant allergic patients","authors":"Kymble Spriggs, Elizabeth Leahy, Nicole Weibel, Sara Barnes","doi":"10.1111/all.16319","DOIUrl":"https://doi.org/10.1111/all.16319","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"6 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142174620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algorithms in allergy: Diagnosis and management of atopic dermatitis in adulthood","authors":"M. Grace Hren, Ester Del Duca, Helen He, Andrew L. Ji, Emma Guttman‐Yassky","doi":"10.1111/all.16315","DOIUrl":"https://doi.org/10.1111/all.16315","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"149 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE-mediated food allergies.","authors":"C L Lai, B Santner-Nanan, P J Maltese, C K S Ong, D J Palmer, D E Campbell, M Makrides, M Gold, R Nanan, S L Prescott, P S Hsu","doi":"10.1111/all.16310","DOIUrl":"https://doi.org/10.1111/all.16310","url":null,"abstract":"<p><strong>Background: </strong>Reasons for Th2 skewing in IgE-mediated food allergies remains unclear. Clinical observations suggest impaired T cell activation may drive Th2 responses evidenced by increased atopic manifestations in liver transplant patients on tacrolimus (a calcineurin inhibitor). We aimed to assess differentiation potential, T cell activation and calcium influx of naïve CD4⁺ T cells in children with IgE-mediated food allergies.</p><p><strong>Methods: </strong>Peripheral blood mononuclear cells from infants in the Starting Time for Egg Protein (STEP) Trial were analyzed by flow cytometry to assess Th1/Th2/Treg development. Naïve CD4⁺ T cells from children with and without food allergies were stimulated for 7 days to assess Th1/Th2/Treg transcriptional factors and cytokines. Store operated calcium entry (SOCE) was measured in children with and without food allergies. The effect of tacrolimus on CD4⁺ T cell differentiation was assessed by treating stimulated naïve CD4⁺ T cells from healthy volunteers with tacrolimus for 7 days.</p><p><strong>Results: </strong>Egg allergic infants had impaired development of IFNγ⁺ Th1 cells and FoxP3⁺ transitional CD4⁺ T cells compared with non-allergic infants. This parallels reduced T-bet, IFNγ and FoxP3 expression in naïve CD4⁺ T cells from food allergic children after in vitro culture. SOCE of naïve CD4⁺ T cells was impaired in food allergic children. Naïve CD4⁺ T cells treated with tacrolimus had reduced IFNγ, T-bet, and FoxP3, but preserved IL-4 expression.</p><p><strong>Conclusions: </strong>In children with IgE-mediated food allergies, dysregulation of T helper cell development is associated with impaired SOCE, which underlies an intrinsic impairment in Th1 and Treg differentiation. Along with tacrolimus-induced Th2 skewing, this highlights an important role of SOCE/calcineurin pathway in T helper cell differentiation.</p>","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma","authors":"Horace Rhee,&nbsp;Lindsay M. Henderson,&nbsp;Rebecca N. Bauer,&nbsp;Kit Wong,&nbsp;Tracy L. Staton,&nbsp;David F. Choy,&nbsp;Prajna Banerjee,&nbsp;Victor Poon,&nbsp;Kenta Yoshida,&nbsp;Chen Chen,&nbsp;Keyi Long,&nbsp;Gizette Sperinde,&nbsp;Steven T. Laing,&nbsp;Nicholas S. Jones,&nbsp;Sara B. Glickstein,&nbsp;Parul Dayal,&nbsp;Alice Fong,&nbsp;Ajit Dash,&nbsp;Grazyna Pulka,&nbsp;Brian Leaker,&nbsp;Dave Singh,&nbsp;Peter Bradding","doi":"10.1111/all.16309","DOIUrl":"10.1111/all.16309","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Tryptase, a mast cell protease, has been identified as a potential therapeutic target in managing patients with refractory asthma. We assessed the efficacy, safety, pharmacokinetics, and pharmacodynamics of MTPS9579A, an anti-tryptase antibody, in a phase 2a randomized trial for patients with uncontrolled asthma and a phase 1c trial to understand activity within the lower respiratory tract.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Phase 2a patients (<i>n</i> = 134) received 1800 mg MTPS9579A or placebo intravenously every 4 weeks for 48 weeks. The primary endpoint was time to the first composite exacerbation event. Phase 1c patients (<i>n</i> = 27) received one intravenous dose of 300 or 1800 mg MTPS9579A or placebo. Both trials measured MTPS9579A concentrations and effects on tryptase in serum and nasal lining fluid; phase 1c also analyzed bronchial lining fluid.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MTPS9579A did not meet the primary endpoint (hazard ratio = 0.90; 95% CI: 0.55–1.47; <i>p</i> = 0.6835); exacerbation rates in the placebo group were low. Serum and nasal MTPS9579A pharmacokinetics and tryptase levels were consistent with data from healthy volunteers. However, in phase 1c patients, compared to nasal levels, MTPS9579A bronchial concentrations were 6.8-fold lower, and bronchial active and total tryptase levels were higher (119-fold and 30-fold, respectively). Pharmacokinetic/pharmacodynamic modeling predicted intravenous doses of 3800 mg every 4 weeks would be necessary to achieve 95% active tryptase inhibition from baseline.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The MTPS9579A dose tested in the phase 2a study was insufficient to inhibit tryptase in bronchial lining fluid, likely contributing to the observed lack of efficacy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 11","pages":"2993-3004"},"PeriodicalIF":12.6,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.16309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cytotoxic effector memory CD8⁺ T cells with sustained unresponsiveness after peanut oral immunotherapy.","authors":"Hana Seastedt, Xiaorui Han, Andrea Fernandes, Stephen J Galli, Scott D Boyd, Kari C Nadeau, Monali Manohar, Sharon Chinthrajah","doi":"10.1111/all.16307","DOIUrl":"https://doi.org/10.1111/all.16307","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue levels of Alternaria allergen Alt a 1 reflect recurrence of refractory airway diseases.","authors":"Yui Miyabe, Tomoe Abe, Toshiki Yamada, Tentaro Endo, Yohei Kawasaki, Shinsuke Suzuki, Misaki Arima, Shigeharu Ueki, Takechiyo Yamada","doi":"10.1111/all.16294","DOIUrl":"https://doi.org/10.1111/all.16294","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":" ","pages":""},"PeriodicalIF":12.6,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to correspondence: “The effectiveness of pollen allergen immunotherapy on allergic rhinitis over 18 years: A national cohort study in Denmark”","authors":"Peter Bager,&nbsp;Jan Wohlfahrt,&nbsp;Mads Melbye","doi":"10.1111/all.16312","DOIUrl":"10.1111/all.16312","url":null,"abstract":"","PeriodicalId":122,"journal":{"name":"Allergy","volume":"79 10","pages":"2897-2898"},"PeriodicalIF":12.6,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142118483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}