To completely solve the problem of fatigue cracking issue of orthotropic steel bridge decks (OSDs), the authors proposed a steel–ultra-high performance concrete (UHPC) lightweight composite deck (LWCD) with closed ribs in 2010. Based on the successful application of that LWCD, an adaptation incorporating an innovative composite deck structure, i.e., the hot-rolled section steel–UHPC composite deck with open ribs (SSD) is proposed in this paper, aiming to simplify the fabrication process as well as to reduce the cost of LWCD. Based on a long-span cable-stayed bridge, a design scheme is proposed and is compared with the conventional OSD scheme. Further, a finite element (FE) calculation is conducted to reflect both the global and local behavior of the SSD scheme, and it is found that the peaked stresses in the SSD components are less than the corresponding allowable values. A static test is performed for an SSD strip specimen to understand the anti-cracking behavior of the UHPC layer under negative bending moments. The static test results indicate that the UHPC layer exhibited a satisfactory tensile toughness, the UHPC tensile strength obtained from the test is 1.8 times the calculated stress by the FE model of the real bridge. In addition, the fatigue stresses of typical fatigue-prone details in the SSD are calculated and evaluated, and the influences of key design parameters on the fatigue performance of the SSD are analyzed. According to the fatigue results, the peaked stress ranges for all of the 10 fatigue-prone details are within the corresponding constant amplitude fatigue limits. Then a fatigue test is carried out for another SSD strip specimen to explore the fatigue behavior of the fillet weld between the longitudinal and transverse ribs. The specimen failed at the fillet weld after equivalent 47.5 million cycles of loading under the design fatigue stress range, indicating that the fatigue performance of the SSD could meet the fatigue design requirement. Theoretical calculations and experiments provide a basis for the promotion and application of this structure in bridge engineering.