Pub Date : 2026-02-10DOI: 10.1053/j.gastro.2025.10.027
Yael Hoffman, Audelia Eshel Fuhrer, Michal Levy, Diana Kazanov, Nadir Arber, Shiran Shapira
{"title":"Long-Term, Prospective Assessment of Cancer Risk in APC c.3920T>A (I1307K) Carriers: Evidence From a Cohort of Over 21,000 Healthy Individuals.","authors":"Yael Hoffman, Audelia Eshel Fuhrer, Michal Levy, Diana Kazanov, Nadir Arber, Shiran Shapira","doi":"10.1053/j.gastro.2025.10.027","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.10.027","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.1,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-10DOI: 10.1053/j.gastro.2025.12.002
Walter Reinisch, Jens Rittscher, Marietta Iacucci, Simon Travis, Matthias Friedrich
Multimodal profiling of inflammatory bowel disease (IBD) patient tissue and blood samples has revealed the disease spectrum in unprecedented detail, and cellular and molecular correlates of disease severity and outcome in IBD have been elaborated. Incorporating these in the clinical setting would offer a unique opportunity to increase the granularity of current clinical measures and to better assess treatment response. Remission and healing at a cellular/molecular level are also likely to have predictive value for long-term outcomes. Here, we outline a path forward to implementing the most promising molecular disease descriptors as future clinical treatment targets in IBD. We focus on the concept of cellular/molecular measures of inflammation, remission, healing, response to therapy, and target pathway engagement. Monitoring mode-of-action-specific pharmacodynamic modules in the context of disease-related resolution pathways will guide assessment of novel and existing therapies. Artificial intelligence-assisted tools will be key to enabling this development, improving reproducibility, limiting costs, and delivering fast detection.
{"title":"Toward Integration of Molecular Measures and Artificial Intelligence-Based Assessments With Clinical End Points in Inflammatory Bowel Disease.","authors":"Walter Reinisch, Jens Rittscher, Marietta Iacucci, Simon Travis, Matthias Friedrich","doi":"10.1053/j.gastro.2025.12.002","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.12.002","url":null,"abstract":"<p><p>Multimodal profiling of inflammatory bowel disease (IBD) patient tissue and blood samples has revealed the disease spectrum in unprecedented detail, and cellular and molecular correlates of disease severity and outcome in IBD have been elaborated. Incorporating these in the clinical setting would offer a unique opportunity to increase the granularity of current clinical measures and to better assess treatment response. Remission and healing at a cellular/molecular level are also likely to have predictive value for long-term outcomes. Here, we outline a path forward to implementing the most promising molecular disease descriptors as future clinical treatment targets in IBD. We focus on the concept of cellular/molecular measures of inflammation, remission, healing, response to therapy, and target pathway engagement. Monitoring mode-of-action-specific pharmacodynamic modules in the context of disease-related resolution pathways will guide assessment of novel and existing therapies. Artificial intelligence-assisted tools will be key to enabling this development, improving reproducibility, limiting costs, and delivering fast detection.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.1,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-10DOI: 10.1053/j.gastro.2025.09.052
Vangelis J Giamouris, Tassos Grammatikopoulos
{"title":"Response to \"The Natural History of Gastroesophageal Varices in Children With Portal Hypertension\".","authors":"Vangelis J Giamouris, Tassos Grammatikopoulos","doi":"10.1053/j.gastro.2025.09.052","DOIUrl":"10.1053/j.gastro.2025.09.052","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.1,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1053/j.gastro.2025.11.008
Natasha Haskey, Jiayu Ye, Ayva Lewis, Munazza Yousuf, Raylene A Reimer, Maitreyi Raman
{"title":"Time-Restricted Feeding Reduces Body Mass Index, Visceral Adiposity, Systemic Inflammation, and Clinical Disease Activity in Adults With Crohn's Disease: A Randomized Controlled Study.","authors":"Natasha Haskey, Jiayu Ye, Ayva Lewis, Munazza Yousuf, Raylene A Reimer, Maitreyi Raman","doi":"10.1053/j.gastro.2025.11.008","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.11.008","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.1,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-09DOI: 10.1053/j.gastro.2025.11.007
Ashley H Beecham, Dermot P B McGovern, Steven W Brugger, Mary F Davis, Esther A Torres, Lissette Gomez, Dalin Li, Paola Lopez-Marte, Mark J Daly, Christine Stevens, Shaohong Yang, Sweta Sinha, Emebet Mengesha, James Leavitt, Oriana M Damas, Maria A Quintero, Stephan R Targan, Shervin Rabizadeh, Ksenija Sabic, Judy H Cho, Maria T Abreu, Jacob L McCauley, Talin Haritunians
Background & aims: Genetic admixture of United States Hispanic individuals provides a unique opportunity to examine ancestral origins of inflammatory bowel disease (IBD) risk. In ∼7.3K Hispanic participants (1660 IBD cases; 5614 controls), we examined ancestral heterogeneity of IBD clinical phenotypes and sought to identify IBD risk loci that displayed heterogeneity of effect or were ancestry-specific.
Methods: Association of genetic ancestry with clinical phenotypes was evaluated. We conducted an ancestry-informed genome-wide (GW) association study for IBD, ulcerative colitis, and Crohn's disease (CD) to obtain ancestry-specific effect size estimates for alleles from African (AFR), European (EUR), and Amerindian (AIAN) origin. Ancestry-specific replication was assessed in All of Us Hispanic participants and transferability was evaluated for populations with similar ancestral origin.
Results: Clinical phenotypes were associated with higher AFR (colonic, penetrating, or perianal CD; later age at diagnosis; IBD-related surgery) or AIAN ancestry (colonic CD). GW EUR-specific associations were observed within established loci for CD (NOD2, IL23R, HLA-DRA) and ulcerative colitis (HLA locus). For AFR or AIAN alleles, novel GW associations were observed in 14 loci. One AFR-specific IBD GW (PCGEM1) and 2 AFR-specific suggestive (TYROBP/LRFN3) associations replicated in All of Us. Several suggestive associations demonstrated transferability (AFR-specific TYROBP/LRFN3 and AIAN-specific GAD2). Several novel IBD risk variants also demonstrated association with clinical phenotypes.
Conclusions: Ancestry-informed regression enabled identification of novel AFR and AIAN-specific risk alleles, which may also inform observed phenotypic differences. We have shown that some previously identified IBD loci have associations that are EUR-specific. These findings highlight the importance of genetic ancestry for elucidating the biological underpinnings of IBD and may have important pharmacogenetic implications.
{"title":"Genomic Insights Into Inflammatory Bowel Disease in United States Hispanic Participants: An Ancestry-Focused Study.","authors":"Ashley H Beecham, Dermot P B McGovern, Steven W Brugger, Mary F Davis, Esther A Torres, Lissette Gomez, Dalin Li, Paola Lopez-Marte, Mark J Daly, Christine Stevens, Shaohong Yang, Sweta Sinha, Emebet Mengesha, James Leavitt, Oriana M Damas, Maria A Quintero, Stephan R Targan, Shervin Rabizadeh, Ksenija Sabic, Judy H Cho, Maria T Abreu, Jacob L McCauley, Talin Haritunians","doi":"10.1053/j.gastro.2025.11.007","DOIUrl":"10.1053/j.gastro.2025.11.007","url":null,"abstract":"<p><strong>Background & aims: </strong>Genetic admixture of United States Hispanic individuals provides a unique opportunity to examine ancestral origins of inflammatory bowel disease (IBD) risk. In ∼7.3K Hispanic participants (1660 IBD cases; 5614 controls), we examined ancestral heterogeneity of IBD clinical phenotypes and sought to identify IBD risk loci that displayed heterogeneity of effect or were ancestry-specific.</p><p><strong>Methods: </strong>Association of genetic ancestry with clinical phenotypes was evaluated. We conducted an ancestry-informed genome-wide (GW) association study for IBD, ulcerative colitis, and Crohn's disease (CD) to obtain ancestry-specific effect size estimates for alleles from African (AFR), European (EUR), and Amerindian (AIAN) origin. Ancestry-specific replication was assessed in All of Us Hispanic participants and transferability was evaluated for populations with similar ancestral origin.</p><p><strong>Results: </strong>Clinical phenotypes were associated with higher AFR (colonic, penetrating, or perianal CD; later age at diagnosis; IBD-related surgery) or AIAN ancestry (colonic CD). GW EUR-specific associations were observed within established loci for CD (NOD2, IL23R, HLA-DRA) and ulcerative colitis (HLA locus). For AFR or AIAN alleles, novel GW associations were observed in 14 loci. One AFR-specific IBD GW (PCGEM1) and 2 AFR-specific suggestive (TYROBP/LRFN3) associations replicated in All of Us. Several suggestive associations demonstrated transferability (AFR-specific TYROBP/LRFN3 and AIAN-specific GAD2). Several novel IBD risk variants also demonstrated association with clinical phenotypes.</p><p><strong>Conclusions: </strong>Ancestry-informed regression enabled identification of novel AFR and AIAN-specific risk alleles, which may also inform observed phenotypic differences. We have shown that some previously identified IBD loci have associations that are EUR-specific. These findings highlight the importance of genetic ancestry for elucidating the biological underpinnings of IBD and may have important pharmacogenetic implications.</p>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.1,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146141973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-06DOI: 10.1053/j.gastro.2025.12.037
Jack London, Shahida Din, Alex Bottle, Jonathan Blackwell
No Abstract
没有抽象的
{"title":"Defying GRAVITI – Reporting safety data in treat-through studies with rescue mechanisms","authors":"Jack London, Shahida Din, Alex Bottle, Jonathan Blackwell","doi":"10.1053/j.gastro.2025.12.037","DOIUrl":"https://doi.org/10.1053/j.gastro.2025.12.037","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"9 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1053/j.gastro.2026.01.029
Ya-Nan Wang, Ming Xu, Feng Gao
{"title":"A Rare and Reversible Cause of Gastric Wall Thickening and Severe Anemia.","authors":"Ya-Nan Wang, Ming Xu, Feng Gao","doi":"10.1053/j.gastro.2026.01.029","DOIUrl":"10.1053/j.gastro.2026.01.029","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":" ","pages":""},"PeriodicalIF":25.1,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146137496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1053/j.gastro.2026.01.027
Saowanee Ngamruengphong, Dennis Yang
No Abstract
没有抽象的
{"title":"Reply to Ichimasa et al, Nakajima et al, and Agargün and Besisik","authors":"Saowanee Ngamruengphong, Dennis Yang","doi":"10.1053/j.gastro.2026.01.027","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.01.027","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"134 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-05DOI: 10.1053/j.gastro.2026.01.022
Hussain Safar, Osman Mahamud, Sumeet Talwar, Joseph Sung, Laura Targownik, Ronald Chow
No Abstract
没有抽象的
{"title":"H Pylori Eradication in Healthy Adults Not Strongly Associated with Improved Mortality: A Fragility Index Analysis","authors":"Hussain Safar, Osman Mahamud, Sumeet Talwar, Joseph Sung, Laura Targownik, Ronald Chow","doi":"10.1053/j.gastro.2026.01.022","DOIUrl":"https://doi.org/10.1053/j.gastro.2026.01.022","url":null,"abstract":"No Abstract","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"24 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146122112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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