Gastroenterology最新文献

{"title":"Obesity-Facilitated Colon Cancer Progression Is Mediated by Increased Diacylglycerol O-Acyltransferases 1 and 2 Levels","authors":"Jenisha Ghimire ,&nbsp;Morgan E. Collins ,&nbsp;Patricia Snarski ,&nbsp;Angelle N. King ,&nbsp;Emmanuelle Ruiz ,&nbsp;Rida Iftikhar ,&nbsp;Harrison M. Penrose ,&nbsp;Krzysztof Moroz ,&nbsp;Tyler Rorison ,&nbsp;Melody Baddoo ,&nbsp;Muhammad Anas Naeem ,&nbsp;Arnold H. Zea ,&nbsp;Scott T. Magness ,&nbsp;Erik F. Flemington ,&nbsp;Susan E. Crawford ,&nbsp;Suzana D. Savkovic","doi":"10.1053/j.gastro.2024.09.011","DOIUrl":"10.1053/j.gastro.2024.09.011","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>The obesity epidemic is associated with increased colon cancer progression. As lipid droplets (LDs) fuel tumor growth, we aimed to determine the significance of diacyltransferases (diacylglycerol o-acyltransferases 1 and 2 [DGAT1/2]), responsible for LDs biogenesis, in obesity-mediated colonic tumorigenesis.</div></div><div><h3>Methods</h3><div>Human colon cancer samples, colon cancer cells, colonospheres, and <em>Apc</em>^Min/+ colon cancer mouse model on a high-fat diet were employed. For DGAT1/2 inhibition, enzymatic inhibitors and small interfering RNA were used. Expression, pathways, cell cycle, and growth were assessed. Bioinformatic analyses of CUT&amp;RUN and RNA sequencing data were performed.</div></div><div><h3>Results</h3><div>DGAT1/2 levels in human colon cancer tissue are significantly elevated with disease severity and obesity (vs normal). Their levels are increased in human colon cancer cells (vs nontransformed) and further enhanced by fatty acids prevalent in obesity; augmented DGAT2 expression is MYC-dependent. Inhibition of DGAT1/2 improves FOXO3 activity by attenuating PI3K, resulting in reduced MYC-dependent DGAT2 expression and accumulation of LDs, suggesting feedback. This inhibition attenuated growth in colon cancer cells and colonospheres via FOXO3/p27kip1 cell cycle arrest and reduced colonic tumors in <em>Apc</em>^Min/+ mice on a high-fat diet. Transcriptomic analysis revealed that DGAT1/2 inhibition targeted metabolic and tumorigenic pathways in human colon cancer and colon cancer crypts, stratifying human colon cancer samples from normal. Further analysis revealed that this inhibition is predictive of advanced disease-free state and survival in patients with colon cancer.</div></div><div><h3>Conclusions</h3><div>This is a novel mechanism of DGAT1/2-dependent metabolic and tumorigenic remodeling in obesity-facilitated colon cancer, providing a platform for future development of effective treatments for patients with colon cancer.</div></div>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 2","pages":"Pages 286-299.e6"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142283933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “Association of GLP-1 Receptor Agonists and Hepatocellular Carcinoma Incidence and Hepatic Decompensation in Patients With Type 2 Diabetes”","authors":"James Cheng-Chung Wei,&nbsp;Ching-Nung Wu,&nbsp;Wei-Chun Cheng","doi":"10.1053/j.gastro.2024.09.039","DOIUrl":"10.1053/j.gastro.2024.09.039","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 2","pages":"Page 424"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142449792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Preventative Effects of Vonoprazan Relative to Intravenous Proton Pump Inhibitors Following Endoscopic Intervention in Peptic Ulcers","authors":"Weizhen Tang,&nbsp;Tai-Hang Liu,&nbsp;Ying-Bo Li","doi":"10.1053/j.gastro.2024.09.041","DOIUrl":"10.1053/j.gastro.2024.09.041","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 2","pages":"Pages 430-431"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The New Horizon of Clostridioides difficile Infection Treatment","authors":"Ed J. Kuijper,&nbsp;Kevin W. Garey","doi":"10.1053/j.gastro.2024.10.032","DOIUrl":"10.1053/j.gastro.2024.10.032","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 2","pages":"Pages 219-222"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AGA Clinical Practice Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation in At-Risk Individuals","authors":"Faisal S. Ali ,&nbsp;Mindie H. Nguyen ,&nbsp;Ruben Hernaez ,&nbsp;Daniel Q. Huang ,&nbsp;Julius Wilder ,&nbsp;Alejandro Piscoya ,&nbsp;Tracey G. Simon ,&nbsp;Yngve Falck-Ytter","doi":"10.1053/j.gastro.2024.11.008","DOIUrl":"10.1053/j.gastro.2024.11.008","url":null,"abstract":"<div><h3>Background &amp; Aims</h3><div>Hepatitis B reactivation (HBVr) can occur due to a variety of immune-modulating exposures, including multiple drug classes and disease states. Antiviral prophylaxis can be effective in mitigating the risk of HBVr. In select cases, clinical monitoring without antiviral prophylaxis is sufficient for managing the risk of HBVr. This clinical practice guideline update aims to inform frontline health care practitioners by providing evidence-based practice recommendation for the management of HBVr in at-risk individuals.</div></div><div><h3>Methods</h3><div>The Grading of Recommendations Assessment, Development and Evaluation framework was used to assess evidence and make recommendations. The panel conducted a systematic evidence review to identify new studies since publication of the first version of this clinical practice guideline in 2014. The Evidence to Decision framework was used to develop recommendations regarding the role of antiviral prophylaxis and monitoring without antiviral prophylaxis for management of HBVr. Clinical recommendations were based on the balance between desirable and undesirable effects, patient values, costs, and health equity considerations.</div></div><div><h3>Results</h3><div>The panel agreed on 4 recommendations. Based on evidence and baseline risk assessment, the panel made a strong recommendation in favor of antiviral prophylaxis for individuals at high risk of HBVr. For individuals at moderate risk of HBVr, a conditional recommendation was made in favor of antiviral prophylaxis. For individuals at low risk of HBVr, a conditional recommendation was made in favor of monitoring alone without antiviral prophylaxis. Monitoring should be performed at 1- to 3-month intervals, and must include assessment of hepatitis B viral load in addition to assessment of alanine aminotransferase. For individuals deemed to be at-risk of HBVr, the panel agreed on a strong recommendation in favor of testing for HBV; given universal Centers for Disease Control and Prevention screening guidance for hepatitis B for all adults 18 years and older by testing for HBV surface antigen, hepatitis B surface antibody, and total hepatitis B core antibody, stratifying screening practices by magnitude of HBVr risk is no longer needed.</div></div><div><h3>Conclusions</h3><div>This document provides updated guidance for the management of HBVr in at-risk individuals. Limitations and gaps in the evidence are highlighted. This guideline is expected to require updating in 5 years from publication.</div></div>","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 2","pages":"Pages 267-284"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SKIN TAG EXCISION IN CROHN’S DISEASE: FIRST DO NO HARM?","authors":"Ece Unal,&nbsp;Olga Lavryk,&nbsp;Arielle Kanters,&nbsp;Anna Spivak,&nbsp;Jeremy Lipman,&nbsp;Clifton Fulmer,&nbsp;Katherine Falloon,&nbsp;Taha Qazi,&nbsp;Ben Cohen,&nbsp;Stefan Holubar","doi":"10.1053/j.gastro.2025.01.108","DOIUrl":"10.1053/j.gastro.2025.01.108","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 3","pages":"Page S37"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REGIONAL AND SOCIOECONOMIC DISPARITIES IN ULCERATIVE COLITIS AND COLORECTAL CANCER RELATED MORTALITY IN THE UNITED STATES AND TEXAS: A 21 YEAR RETROSPECTIVE STUDY","authors":"Sidra Naz,&nbsp;Hira Naz","doi":"10.1053/j.gastro.2025.01.137","DOIUrl":"10.1053/j.gastro.2025.01.137","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 3","pages":"Page S51"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TOBACCO AND INFLAMMATORY BOWEL DISEASE: AN IN-DEPTH EXAMINATION OF NATIONAL HOSPITAL OUTCOMES, ILLUMINATING DISTINCT EFFECTS IN ULCERATIVE COLITIS AND CROHN’S DISEASE IN THE UNITED STATES","authors":"Mohammed El-Dallal,&nbsp;Caleb Meaige,&nbsp;Zarna Bambhroliya,&nbsp;M’hamed Turki,&nbsp;Swapna Sirigireddy,&nbsp;Sherif Ahmed,&nbsp;Wesam Frandah","doi":"10.1053/j.gastro.2025.01.120","DOIUrl":"10.1053/j.gastro.2025.01.120","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 3","pages":"Pages S44-S45"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TARGETING MYD88-JAK2 SIGNALING IN ABERRANTLY DIFFERENTIATED MESENCHYMAL PROGENITORS IN ULCERATIVE COLITIS","authors":"Ronaldo Paolo Panganiban,&nbsp;Marina Chulkina,&nbsp;Christina McAninch,&nbsp;Steven McAninch,&nbsp;Walter Koltun,&nbsp;Gregory Yochum,&nbsp;Irina Pinchuk","doi":"10.1053/j.gastro.2025.01.064","DOIUrl":"10.1053/j.gastro.2025.01.064","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 3","pages":"Pages S8-S9"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLAMMATORY BOWEL DISEASES AND RISKS OF GENITOURINARY CANCERS: A SYSTEMIC REVIEW AND META-ANALYSIS","authors":"Zhongyuan Zhang,&nbsp;Natchaya Polpichai","doi":"10.1053/j.gastro.2025.01.099","DOIUrl":"10.1053/j.gastro.2025.01.099","url":null,"abstract":"","PeriodicalId":12590,"journal":{"name":"Gastroenterology","volume":"168 3","pages":"Page S32"},"PeriodicalIF":25.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}