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A Decision Support System For Skill-Based Nurse Scheduling In An Intensive Care Unit 重症监护病房基于技能的护士排班决策支持系统
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-04-17 DOI: 10.35378/gujs.1218158
Orhan Parildar, Ç. Akyürek, D. Akay
The main goal of health institutions is to provide the health services needed by society at the desired quality with the lowest possible cost. Considering the total number of employees in health institutions, nurse assignment and scheduling have an essential role in increasing efficiency and improving service quality due to the one-to-one interaction of nurses with patients. This study proposes a nurse scheduling model based on nurses’ skill levels incorporated into a decision support system. The skill level of nurses is assessed using Analytic Hierarchy Process and Technique for Order Preference by Similarity to Ideal Solution method based on eight criteria. The nurse scheduling problem is then modeled with 0-1 Goal Programming, considering the skill assessment as a constraint. The applicability of the proposed model is examined for the assignment and scheduling conditions of nurses at the 3rd level of surgical intensive care in a general hospital, and the valuable aspects of the proposed approach are discussed. When the proposed solution is compared with the current situation, it is realized that one nurse is saved without worsening the constraints.
卫生机构的主要目标是以尽可能低的成本以期望的质量提供社会所需的卫生服务。考虑到卫生机构的员工总数,由于护士与患者的一对一互动,护士的分配和调度在提高效率和提高服务质量方面发挥着至关重要的作用。本研究提出了一个基于护士技能水平的护士调度模型,并将其纳入决策支持系统。运用层次分析法和理想解相似排序偏好技术,以八个标准为基础,对护士的技能水平进行了评估。然后,将技能评估作为约束条件,用0-1目标规划对护士排班问题进行建模。检验了所提出的模型在综合医院外科重症监护三级护士分配和调度条件下的适用性,并讨论了所提出方法的宝贵方面。当将所提出的解决方案与当前情况进行比较时,可以实现在不恶化约束的情况下节省一名护士。
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引用次数: 0
2-(((2,4-Dichlorophenyl)imino)methyl)-3,4-difluorophenol: X-ray, DFT, MEP, HOMO-LUMO, NLO, Hirshfeld surfaces, ADMET profiling, target identification, antipsychotic activity against dopamine D2 and serotonin 5-HT2A receptors 2-(((2,4-二氯苯基)亚氨基)甲基)-3,4-二氟苯酚:X射线、DFT、MEP、HOMO-LUMO、NLO、Hirschfeld表面、ADMET图谱、靶标鉴定、抗多巴胺D2和5-羟色胺5-HT2A受体的抗精神病活性
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-04-17 DOI: 10.35378/gujs.1241638
Songül Şahin
Halogenated compounds, especially fluorine and chlorine, play a key role in drug development. They account for a large proportion of all approved drug molecules. The importance of these two halogens stems from their remarkable effects on biological activity and pharmacokinetic properties. The study presented here aims to give the results obtained by the DFT methods and in silico medicinal evaluations of a newly synthesized small molecule. The small molecule belongs to the Schiff base class of organic compounds and is substituted with halogen atoms. The tetrahalogenated compound (THSB) Schiff base, 2-(((2,4-dichlorophenyl)imino)methyl)-3,4-difluorophenol, was first synthesized via the classical condensation method and then characterized by spectroscopic techniques. The THSB optimized by the B3LYP method was evaluated in terms of geometrical parameters, surface area (MEP and Hirshfeld analysis) and secondary interaction analysis, NLO properties, and electronic properties (HOMO-LUMO and UV-Vis). Second, THSB was evaluated regarding medicinal chemistry, physicochemical and pharmacokinetic properties, and toxicity (ADMET). Then, we comprehensively investigated the potential biological targets of THSB. Using the results of the SwissSimilarity analysis, we investigated the antagonistic effects of THSB against serotonin 5-HT2A and dopamine D2 receptors. Docking results were compared with the known antipsychotics, clozapine and risperidone. THSB showed a higher antagonistic effect than clozapine for the D2 receptor. However, risperidone proved to be the most effective antagonist for both targets. The binding energies of THSB, risperidone, and clozapine were -8.30, -11.84, and -8.07 kcal/mol, respectively, for D2; those of THSB, risperidone, and clozapine were -6.94, -11.47, and -10.10 kcal/mol, respectively, for 5-HT2A.
卤代化合物,特别是氟和氯,在药物开发中起着关键作用。它们在所有批准的药物分子中占很大比例。这两种卤素的重要性源于它们对生物活性和药代动力学特性的显著影响。本文的研究旨在给出DFT方法和对一种新合成的小分子的计算机医学评价所获得的结果。小分子属于希夫碱类有机化合物,被卤素原子取代。采用经典缩合法合成了四卤代化合物(THSB)席夫碱2-(((2,4-二氯苯基)亚氨基)甲基)-3,4-二氟苯酚,并用光谱技术对其进行了表征。通过B3LYP方法优化的THSB从几何参数、表面积(MEP和Hirshfeld分析)和二次相互作用分析、NLO性质和电子性质(HOMO-LUMO和UV-Vis)方面进行了评估。其次,对THSB的药物化学、理化和药代动力学特性以及毒性(ADMET)进行了评估。然后,我们全面研究了THSB的潜在生物靶标。利用SwissSimilarity分析的结果,我们研究了THSB对5-羟色胺5-HT2A和多巴胺D2受体的拮抗作用。将对接结果与已知的抗精神病药物氯氮平和利培酮进行比较。THSB对D2受体的拮抗作用高于氯氮平。然而,利培酮被证明是对这两个靶点最有效的拮抗剂。THSB、利培酮和氯氮平对D2的结合能分别为-8.30、-11.84和-8.07kcal/mol;THSB、利培酮和氯氮平对5-HT2A的敏感性分别为-6.94、-11.47和-10.10kcal/mol。
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引用次数: 0
Calculating Weibull coefficients using the Maximum Likelihood Method and comparing performance across sites 使用最大似然法计算威布尔系数并比较各个站点的性能
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-04-14 DOI: 10.35378/gujs.1092617
Alper Kaplan
The harmony of the Weibull Distribution Function (WDF) and real data from three different places was investigated in this research. The coefficients of the WDF were calculated using the Maximum Likelihood Method (MLM) in the Adana, Osmaniye, and Hatay regions. One of the main goals of this research is to see how the MLM's performance varies in different places with different mean wind speeds. For the purpose of justifying the MLM's performance, the statistical fits of the computed and measured hourly wind speed data were analyzed. The performance of the indicated approach in all three selected locations was evaluated using the Root Mean Square Error (RMSE), Coefficient of Determination (R2), and Mean Percentage Error (MPE) error analysis tests, according to the results. Also estimated for all three regions were wind power densities, which are one of the most essential metrics for estimating a region's wind energy potential. WDF power densities were estimated and compared to real wind power densities generated from measured wind data in three different places. The performance of the strategy described in this paper was investigated in depth in various places with varying geographic characteristics. In addition, in the same years, the performance of the chosen approach was evaluated in detail in three distinct places, and it was seen how geographical factors affected the method's performance.
本文研究了威布尔分布函数(WDF)与三地实测数据的协调性。利用最大似然法(MLM)计算Adana、Osmaniye和Hatay地区的WDF系数。本研究的主要目的之一是观察传送带在不同地点、不同平均风速下的性能变化情况。为了证明MLM的性能,对计算和测量的每小时风速数据进行了统计拟合分析。根据结果,使用均方根误差(RMSE)、决定系数(R2)和平均百分比误差(MPE)误差分析测试来评估所述方法在所有三个选定地点的性能。同时对这三个地区的风力密度进行了估计,这是估计一个地区风能潜力的最重要指标之一。估计了WDF的功率密度,并将其与三个不同地方的实测风力数据产生的实际风力密度进行了比较。在具有不同地理特征的地方,对本文所述策略的效果进行了深入的调查。此外,在同一年,在三个不同的地方对所选方法的性能进行了详细的评估,并看到了地理因素如何影响该方法的性能。
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引用次数: 0
Obtaining Efficient Mutant from the Wild Type Bacillus subtilis E6-5 by Physical and Chemical Mutagenesis for High Efficiency Protease Production, Optimizing the Mutant's Culture Medium 通过物理和化学诱变获得野生型枯草芽孢杆菌E6-5高效蛋白酶突变体,并优化突变体培养基
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-04-11 DOI: 10.35378/gujs.1191006
Büşra Özalpar, E. Demirkan, Tuba Sevgi̇
In this study, to enhance protease production, the wild type of Bacillus subtilis E6-5 was mutagenized by random mutagenesis using ultraviolet radiation and ethidium bromide. After combined treatment, several mutants were obtained. Among these mutants, the mutant strain with the largest proteolytic zone diameter (25 mm) was selected and named Bacillus subtilis ATA38. The enzyme production capacity of the obtained mutant was tested and the mutant strain (404 IU/mL at 24 hours) produced 6.7 times more enzyme than the parental strain (60 IU/mL at 32 hours). The effects of some important parameters in the growth medium on enzyme production were examined. The best carbon, organic nitrogen and metal ion were obtained with wheat starch (525 IU/mL), meat extract (850 IU/mL) and KCl+CaCl2 (548 IU/mL), respectively. pH 6.0, 37°C, 200 rpm, inoculum age 18 hours and inoculation amount 1% were obtained as the best physical factors.To further increase the yield, the best nutritional and physical parameters were combined to create a new modified medium. It was determined that the enzyme yield with mutant strain increased 2.7 times in the modified medium (1096 IU/mL) compared to the control (404 U/mL). The mutant strain (1096 IU/mL) showed an 18.2-fold increase in production compared to the wild type (60 IU/mL) in the modified medium. Protease enzyme obtained from ATA38 mutant strain may have great potential in industry for different purposes.
本研究利用紫外辐射和溴化乙啶对野生型枯草芽孢杆菌E6-5进行随机诱变,以提高蛋白酶的产量。综合处理后,获得了多个突变体。在这些突变体中,选择了蛋白水解带直径最大(25 mm)的突变株,命名为枯草芽孢杆菌ATA38。对获得的突变株产酶能力进行了测试,结果表明,突变株(24小时404 IU/mL)的产酶量是亲本菌株(32小时60 IU/mL)的6.7倍。考察了培养基中一些重要参数对产酶的影响。以小麦淀粉(525 IU/mL)、肉精(850 IU/mL)和KCl+CaCl2 (548 IU/mL)分别获得最佳碳、有机氮和金属离子。最佳物理条件为pH 6.0, 37℃,200 rpm,接种时间18 h,接种量1%。为了进一步提高产量,将最佳的营养参数和物理参数结合起来,创造了一种新的改良培养基。结果表明,在改良培养基(1096 IU/mL)中,突变菌株的酶产率比对照(404 U/mL)提高了2.7倍。与野生型(60 IU/mL)相比,突变菌株(1096 IU/mL)在改良培养基中的产量增加了18.2倍。从ATA38突变株中获得的蛋白酶在工业上具有很大的应用潜力。
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引用次数: 0
Design, Implementation, and Evaluation of an Automated Liquid Dispensing Machine 自动液体点胶机的设计、实现和评估
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-04-04 DOI: 10.35378/gujs.1159197
M. Arowolo, A. Adekunle, O. Martins
The metering of industrial manufacturing liquids is constantly being updated. Using an automated system, metered dispense can now be more accurate to its theoretical value. This system can help reduce the difference between the theoretical and metered volumes in manufacturing applications. This paper describes an automated liquid dispensing machine that uses an AT Mega 328 microcontroller to control the metered volume to the program set-point. The machine's design and implementation include hardware systems assembled from various modules with various functions, such as a microcomputer, power supply, liquid level detection, liquid discharge, conveyor and container detection, and LCD modules. The data collected by the liquid level detection module is analyzed when the system is started to determine the liquid level in the tank. A user loads empty containers onto the conveyor, which are then transferred to the discharge point. The machine calculates the equivalent time in seconds to open the discharge solenoid valve via its control relay and dispense the desired volume based on the user set-point. The experiment performed on the machine with water as the test liquid revealed that the automated dispensing machine's maximum time permissible is 35 s, which corresponds to an equivalent volume of approximately 700 ml of water. Experiments were conducted to compare the theoretical time required to obtain a specified volume to the time required for the machine to dispense the same volume. The results showed that the machine's accuracy is approximately 97.87 %. Therefore, the machine can be used in beverage manufacturing companies, pharmaceutical industries, and laboratories to dispense and fill specified fluids that meet the machine's specifications.
工业制造液体的计量不断更新。使用自动化系统,计量配药现在可以更准确地达到其理论值。该系统可以帮助减少制造应用中理论和计量体积之间的差异。本文介绍了一种自动液体点胶机,该点胶机使用AT Mega 328微控制器控制计量体积到程序设定值。机器的设计和实现包括由各种功能模块组成的硬件系统,如微电脑、电源、液位检测、出液、输送和容器检测,以及LCD模块。在系统启动时,对液位检测模块采集的数据进行分析,确定罐内液位。用户将空容器装载到传送带上,然后将其转移到卸货点。机器通过其控制继电器计算以秒为单位的等效时间打开放电电磁阀,并根据用户设定点分配所需的体积。以水为测试液在机器上进行实验,自动点胶机的最大允许时间为35s,相当于约700ml水的当量体积。进行了实验,以比较获得指定体积所需的理论时间和机器分配相同体积所需的时间。结果表明,该机器的准确率约为97.87%。因此,该机器可用于饮料制造公司,制药行业和实验室,以分配和填充符合机器规格的指定流体。
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引用次数: 0
A comparative study on the generalized spherical fuzzy Einstein aggregation operators 广义球面模糊爱因斯坦聚集算子的比较研究
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-04-01 DOI: 10.35378/gujs.937205
E. Güner, H. Aygün
In this study, we first define some induced generalized spherical fuzzy Einstein aggregation operators such as generalized spherical fuzzy ordered Einstein weighted averaging (GSEOWA), generalized spherical fuzzy hybrid Einstein weighted averaging (GSEHWA), generalized spherical fuzzy ordered Einstein weighted geometric (GSEOWG), and generalized spherical fuzzy hybrid Einstein weighted geometric (GSEHWG) operators. Then, we establish a model for these aggregation operators to solve the multiple attribute group decision-making problems and also we give an illustrative example. Finally, we compare the results given by all defined generalized spherical fuzzy Einstein aggregation operators within the decision-making process.
在本研究中,我们首先定义了一些诱导的广义球面模糊Einstein聚合算子,如广义球面模糊有序Einstein加权平均(GSEOWA)、广义球面模糊混合Einstein权重平均(GSEHWA)、,以及广义球面模糊混合Einstein加权几何算子。然后,我们建立了这些聚合算子的模型来解决多属性群决策问题,并给出了一个示例。最后,我们比较了所有定义的广义球面模糊Einstein聚集算子在决策过程中给出的结果。
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引用次数: 0
ANN and RSM Modelling and Optimization of Paraffins and Aromatics in Crude Oil Distillation Products’ Properties in Iraq 伊拉克原油蒸馏产品性质中石蜡和芳烃的ANN和RSM建模与优化
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-03-30 DOI: 10.35378/gujs.1143087
J. Yamin, Eman Sheet, Ayad ِAL JUBORİ
Back-Propagation neural networks, as well as RSM-DOE techniques, were used to predict the properties of various compositions of Iraqi oil, were presented in this study. Paraffin’s and Aromatics’ effect on petroleum properties, e.g., yield, density, calorific value, and other essential properties, were studied. The input-output data to the neural networks were obtained from existing local refineries in Iraq. Several network architectures were tried, and the networks that best simulate the hydrocracking process were retained. The predictions of the prepared neural networks have been cross-validated against data not initially used in the training process. The networks compared well against this new set of data, with an average per cent error always less than 5 for the various products of the hydrocracking unit.
本研究介绍了反向传播神经网络以及RSM-DEA技术,用于预测伊拉克石油各种成分的性质。研究了石蜡和芳烃对石油性质的影响,如产量、密度、热值和其他基本性质。神经网络的输入输出数据是从伊拉克现有的当地炼油厂获得的。尝试了几种网络结构,并保留了最能模拟加氢裂化过程的网络。准备好的神经网络的预测已经与训练过程中最初未使用的数据进行了交叉验证。这些网络与这组新数据进行了很好的比较,加氢裂化装置的各种产品的平均误差总是小于5。
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引用次数: 0
Investigation of Genes and Their Interactions in Liver Diseases Using Bioinformatics Algorithms 应用生物信息学算法研究肝病中的基因及其相互作用
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-03-20 DOI: 10.35378/gujs.1182561
Saliha Acar, Gıyasettin Özcan, E. Gülbandilar
In this study, we considered progression of liver diseases. Particularly we considered Hepatocellular Carcinoma Cancer, HCC, whose patients have low survival rates. For this purpose, we researched molecular structures and protein interactions involved in the initiation and progression of HCC. We exploited microarray data samples and their gene expression profiles from literature. During analysis, we implemented statistical data analysis techniques and looked for Differentially Expressed Genes during the initiation and progression of HCC. As a result of this analysis we found 12 hub genes, where 3 of them (ANLN, TOP2A and ASPM) were upregulated and the others (CXCL14, LINC01093, OIT3, CLEC4G, THRSP, APOF, CLTRN and FCN3) were downregulated. By performing Gene Ontology Analysis, we classified genes with increased or decreased expressions in terms of cellular component, biological process, and molecular function. Subsequently, we executed protein-protein interaction network analysis and found important interactions between the hub genes. Results of data analysis concluded that these 12 genes and their interactions play a key role in the initiation and progression of significant liver diseases and can be used as a potential biomarker for disease progression. Furthermore, gene feature analysis showed that it is becoming more difficult to compensate functional deficiencies of the proteins encoded by these genes during biological processes. In particular, Gene Ontology Analysis denoted that TOP2A gene associates with many of the biological pathways and a change in the expression of this gene can cause decent problems in many cellular functions.
在这项研究中,我们考虑了肝脏疾病的进展。我们特别考虑了肝癌癌症,HCC,其患者的存活率较低。为此,我们研究了参与HCC发生和发展的分子结构和蛋白质相互作用。我们利用了文献中的微阵列数据样本及其基因表达谱。在分析过程中,我们采用了统计数据分析技术,并在HCC的发生和发展过程中寻找差异表达基因。作为该分析的结果,我们发现了12个枢纽基因,其中3个(ANLN、TOP2A和ASPM)上调,其他基因(CXCL14、LINC01093、OIT3、CLEC4G、THRSP、APOF、CLTRN和FCN3)下调。通过进行基因本体论分析,我们根据细胞成分、生物过程和分子功能对表达增加或减少的基因进行了分类。随后,我们进行了蛋白质-蛋白质相互作用网络分析,发现了中枢基因之间的重要相互作用。数据分析结果表明,这12个基因及其相互作用在重大肝病的发生和发展中发挥着关键作用,可作为疾病进展的潜在生物标志物。此外,基因特征分析表明,在生物过程中,补偿这些基因编码的蛋白质的功能缺陷变得越来越困难。特别是,基因本体论分析表明,TOP2A基因与许多生物途径有关,该基因表达的变化可能会导致许多细胞功能出现严重问题。
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引用次数: 0
Small Size Broadband Printed Antenna for 5G Applications Covering 28 GHz / 38 GHz and 60 GHz Bands 适用于5G应用的小型宽带印刷天线,覆盖28 GHz/38 GHz和60 GHz频带
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-03-18 DOI: 10.35378/gujs.1178594
Gazi University, Vijay Sharma, N. Mishra, Atul Agarwal, N. Gupta
This work offers the radiation insight of a compact modified monopole rectangular printed antenna suitable for 5G applications. A Double copper cladded RT Duroid 5880 material sheet with dimensions 4.4×5.0×0.5mm3 is chosen as the base substrate in the offered design with a loss tangent of 0.004 and a dielectric constant of 2.2. In the provided strategy lower-left corner of a rectangular printed antenna is made in the form of a smooth circular curve. After extensive simulation, a circular slot with an elliptical patch is incorporated into this monopole antenna. The designed antenna parameters are adjusted to cover the impedance bandwidth from 21.7 GHz to more than 70.0 GHz. Three resonances at 28.0 GHz, 38.1 GHz and 60.2 GHz were observed in three bands allocated for 5G communication applications. The efficiency and gain values found sustained in the entire bandwidth range. Stable and desired radiation patterns at all three resonant frequencies 28/38/60 GHz prove the suitability of this antenna for recent 5G applications.
这项工作提供了适用于5G应用的紧凑型改良单极矩形印刷天线的辐射见解。在所提供的设计中,选择尺寸为4.4×5.0×0.5mm3的双铜包覆RT Duroid 5880材料片作为基底,损耗角正切为0.004,介电常数为2.2。在所提供的策略中,矩形印刷天线的左下角被制成平滑圆形曲线的形式。经过广泛的模拟,在单极天线中加入了一个带有椭圆贴片的圆形缝隙。对设计的天线参数进行了调整,以覆盖从21.7 GHz到70.0 GHz以上的阻抗带宽。在分配给5G通信应用的三个频带中,观察到28.0 GHz、38.1 GHz和60.2 GHz的三个谐振。发现在整个带宽范围内保持的效率和增益值。在所有三个谐振频率28/38/60GHz下的稳定和期望的辐射方向图证明了该天线适用于最近的5G应用。
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引用次数: 0
Hybrid Technology for Water Heating Applications: A Review 水加热混合技术的应用综述
IF 0.9 Q3 MULTIDISCIPLINARY SCIENCES Pub Date : 2023-03-17 DOI: 10.35378/gujs.1192114
A. Okubanjo, G. Ofualagba, P. Oshevi̇re
The global energy deficit is currently a critical issue in the energy sector. As a result, the rising energy demand increases the consumption of conventional fossil fuels, contributing to the climate crisis and greenhouse gas emissions. Therefore, the over-reliance on fossil-fuel-based energy necessitates the development of a sustainable energy system to meet the lingering heat demand. Hence, renewable energy and efficient hybrid water heating technologies are viable options for achieving net-zero energy. The economic benefits of these hybrid technologies offer a promising prospect for widespread adoption in increasing hot water production in developing countries. These hybrid technologies are becoming increasingly popular for domestic thermal applications in remote areas to compensate for energy shortages. The paper aims to provide an overview of hybrid renewable water heating technologies, focusing on hybrid configurations, optimization techniques, mono-particle, and hybrid nanofluids and modelling. This paper also highlights the prospects of increasing such systems' economic attractiveness and public adoption.
全球能源赤字目前是能源部门的一个关键问题。因此,不断增长的能源需求增加了传统化石燃料的消耗,加剧了气候危机和温室气体排放。因此,过度依赖化石燃料能源需要开发可持续的能源系统来满足挥之不去的热量需求。因此,可再生能源和高效混合水加热技术是实现净零能源的可行选择。这些混合技术的经济效益为发展中国家增加热水产量提供了广泛采用的前景。这些混合技术在偏远地区的家用热力应用中越来越受欢迎,以弥补能源短缺。本文旨在概述混合可再生水加热技术,重点介绍混合配置、优化技术、单颗粒和混合纳米流体以及建模。本文还强调了提高此类系统的经济吸引力和公众采用率的前景。
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引用次数: 1
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gazi university journal of science
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