Functional Foods in Health and Disease最新文献

{"title":"Modulation of gut microbiota and their metabolites by functional mulberry juice non-thermally pasteurized using microfiltration","authors":"Thitirat Kaewsedam, W. Youravong, Zhenyu Li, S. Wichienchot","doi":"10.31989/ffhd.v12i9.980","DOIUrl":"https://doi.org/10.31989/ffhd.v12i9.980","url":null,"abstract":"Background: Mulberry fruit is a source of phenolic compounds and has biological properties. This study aimed to assess the effects of isomaltooligosaccharide (IMO) added to mulberry juice on prebiotic activity and gut fermentation properties.Objectives: The study aimed to produce mulberry juice supplemented with IMO, which might generate short chain fatty acids (SCFA), and to examine the effects of a prebiotic activity after fecal fermentation.Materials and methods: Functional mulberry juices were prepared with three different levels of isomaltooligosaccharide (IMO), namely 0% (MBI0), 2% (MBI2), and 8% (MBI8). The study tested mulberry juices supplemented with IMO, which generated short-chain fatty acids (SCFA), phenolic metabolites, and favored beneficial gut bacteria, and examined the prebiotic activity after fecal fermentation by the colonic microbiota. A crossflow hollow fiber microfiltration system with a 0.22 μm pore size was employed to deliver permeates considered non-thermally pasteurized juices.Results: The results show that short chain fatty acids (SCFA) included large propionic acid and butyric acid concentrations at 48h. The percent of bifidobacteria significantly increased to 5.03% and 17.53% in 24 hours fermentation of MBI2 and MBI8, respectively. After fecal batch culture fermentation, some anthocyanin metabolites such as 3-(2-hydroxyphenyl) propionic acid, 3,4-dihydroxybenzaldehyde, L-phenylalanine, and aminocaproic acid, were detected. Therefore, IMO can serve as a potential prebiotic ingredient added in mulberry juice for promoting the growth of beneficial gut microbiota.Conclusion: The results show that IMO favored beneficial microorganisms in the gut and contributed to biologically active compounds such as metabolites of polyphenols and anthocyanins in the gut.Keywords: Mulberry, isomaltooligosaccharide, prebiotic, gut microbiota, metabolites","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45317584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corozo (Bactris guineensis) fruit extract has antiviral activity in vitro against SARS-CoV-2","authors":"T. Jaimes-Gualdrón, Lizdany Flórez-Álvarez, M. I. Zapata-Cardona, B. Rojano, M. Rugeles, Wildeman Zapata-Builes","doi":"10.31989/ffhd.v12i9.918","DOIUrl":"https://doi.org/10.31989/ffhd.v12i9.918","url":null,"abstract":"Background: Given the current COVID-19 pandemic, numerous drug development studies are being carried out for the treatment and control of this disease. This study aimed to evaluate the in vitro antiviral potential of Corozo fruit extract (Bactris guineensis) against SARS-CoV-2.Methods: Corozo extract (CE) was prepared from the pulp of mature Corozo fruits. The total content of phenols, flavonoids, and anthocyanins in the extracts was determined using the Folin-Ciocalteu, aluminum chloride, and pH differential methods, respectively. The cytotoxicity on Vero E6 cells was evaluated by MTT assay. Antiviral activity was evaluated by pre-post-treatment using a Colombian isolate of SARS-CoV-2. Viral titer was quantified by plaque assay.Results: Anthocyanin concentration of CE was 144.95 ± 10.3 mg cyanidin-3-glucoside/L. The cytotoxicity of CE on Vero E6 was lower to 20 % at 15.6 g/L. Corozo extract inhibited SARS-CoV-2 at 15.6, 7.8, 3.9 and 1.9 g/L with inhibition percentages of 88.2%, 84%, 59.6% and 56.3%, respectively.Conclusion: This is the first report on the in vitro antiviral effect of Corozo fruit extract against SARS-CoV-2. Since this is a natural product, proven safe for consumption, in the future and with further studies, it could be considered an important functional food that can be useful in preventing strategies to fight against COVID-19.Keywords: Bactris guineensis, Corozo fruit, antiviral activity, SARS-CoV-2, COVID-19.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49393834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism Prediction of Gastro-protective Effects of the Biebersteinia multifida against Ethanol-Induced Gastric Ulcers; an Insilco study","authors":"S. R. Zarchi, Mahdi Dousti, Davood Rezazadeh, E. Sajadi, Sara Rizvand, N. Roozbahani","doi":"10.31989/ffhd.v12i9.964","DOIUrl":"https://doi.org/10.31989/ffhd.v12i9.964","url":null,"abstract":"Introduction: Peptic ulcer disease (PUD) is one of the most common diseases of the gastrointestinal tract. Herbal remedies are alternative therapies that have different gastro protective mechanisms, the gastro protective effect of Biebersteinia multifida (BM) was evaluated previously.Objective: This study was performed to predict the possible mechanism of action of BM bioactive compounds on ameliorating ethanolic PUD in an Insilico study by molecular docking.Methods: Bioactive compounds in BM were screened by Molegro Virtual Docker 6.0 (MVD) for their effects on factors affecting the healing and progression of ethanolic PUD.Results: The principal bioactive compound in BM root that has an ameliorating effect in PUD is the flavonoids luteolin rutinoside. This compound establishes the lowest binding energy with the enzymes xanthine oxidase, cyclooxygenase-2, and superoxide dismutase, respectively.Conclusion: Biebersteinia multifida probably affects the factors involved in ethanolic PUD due to the presence of flavonoids luteolin rutinoside and thus plays a role in the healing of PUD.Keywords: Molecular Docking, Biebersteinia multifida, Peptic ulcer, Molegro Virtual Docker","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43737198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical composition, physicochemical evaluation and sensory analysis of yogurt added with extract of polyphenolic compounds from Quercus crassifolia oak bark","authors":"Eréndira Valencia-Avilés, M. García-Pérez, M. G. Garnica-Romo, J. D. Figueroa-Cárdenas, M. Paciulli, H. Martínez‐Flores","doi":"10.31989/ffhd.v12i9.951","DOIUrl":"https://doi.org/10.31989/ffhd.v12i9.951","url":null,"abstract":"Introduction: A diet high in calories and saturated fats has been associated with health problems that have been increasing worldwide. Therefore, it is required to increase the number of formulated foods that generate well-being to health. Yogurt is a widely consumed food by all sectors of the population and it can be used as a vehicle to incorporate bioactive compounds. The phenolic compounds present in forest residues, such as those from oak bark, can be used and incorporated into yogurt, to increase its benefits as a functional food.Objective: The objective of this study was to develop a multifunctional yogurt enriched with vegetable oil (2.3% w/w) as a source of omega 6 and 3 and adding nanocapsules (24.5% w/w) of an extract of oak bark from Quercus crassifolia, rich in in phenolic compounds and high antioxidant capacity.Methods: Three yogurt formulations were prepared: F1: yogurt was made with non-fat milk, used as a control, F2: yogurt was prepared with non-fat milk and added with vegetable palm oil, and F3: non-fat yogurt was added with vegetable oil and nanoencapsulated oak bark phenolic extract. The yogurts were characterized in their chemical composition, microbiological analysis, and sensory analysis. Results: The multifunctional product F3 and product F2 presented lactic acid bacteria in concentration of 3.01X106 and 4.73x106, respectively, preserving characteristics of probiotic food. Product F3 presented low levels of syneresis (7.34%) and it was significantly different from the control yogurt (9.01%). The viscosity increased from 150 cP in the control yogurt to 341 cP in F3, due to the increase in the concentrations of solids by nanoencapsulating the phenolic. The wall material used for nanoencapsulation was sodium caseinate and mantodextrin. However, this increase in viscosity did not affect the sensory evaluation of the product. There were no significant differences between the control yogurt and the F2 and F3 products.Conclusion: A yogurt added with vegetable oil and nanoencapsulated oak bark phenolic extract was obtained. It was enhanced by the presence of probiotics, bioactive compounds, and essential fatty acids, and then evaluated and accepted by a sensory panel. Nanoencapsulation is a viable alternative to mask the characteristic astringent taste of phenolic compounds because it was not detected by the panelists. Keywords: waste recovery; functional dairy foods; essential fatty acids; probiotics; antioxidants; sensory.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49440860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjuvant benefit of a peptide-rich marine biology formula (LD- 1227) in rheumatoid arthritis: a randomized, double-blind, controlled study","authors":"Lorenzetti Aldo, Solimene Umberto, Rastmanesh Reza, F. Marotta, Fang He, Rasulova S, Aperio Cristiana, Anzulovic Nevenka, Zerbinati Nicola","doi":"10.31989/ffhd.v12i9.960","DOIUrl":"https://doi.org/10.31989/ffhd.v12i9.960","url":null,"abstract":"Introduction. There is a growing interest on non-chemical therapies among patients suffering from rheumatoid arthritis (RA), although safety, efficacy and properly designed studies are often lacking. Objective. The aim of the present investigation was to explore the clinical effectiveness of a marine nutraceutical, LD-1227, endowed by fine molecular biology studies, in the management of RA. Methods. The study design was a 12-week, randomized, double-blind study involving forty patients with stable long-standing RA who were randomized to receive either LD-1227 (n = 20) or Omega-3 (n = 20) on top of their established maintenance therapy. Results. At study recruitment and after 12 weeks of treatment, their Health Assessment Questionnaire (HAQ), erythrocyte sedimentation rate (ESR), visual analogue scale (VAS), and Disease Activity Score (DAS) 28, anxiety and depression analysis, C-reactive protein (CRP) levels, CXCL1, several pro-inflammatory interleukins levels and related gene expression, were compared between the two groups. Primary end point was the proportion of patients with response at weeks 12 as from the 20 % to 50% improvement criteria of the American College of Rheumatology (ACR20). At 12 weeks, ACR20 beneficial response was 81.0 % in LD-1227 group and 44 % in omega-3 group, (p< 0.01). The superiority of LD-1227 appeared also when considering the ACR50 response at 12 weeks (62% in LD-1227 group as compared to 31 % in omega-3 group, p< 0.01). The LD-1227-treated group displayed a significant improvement of VAS scale, HAQ score, morning stiffness and tender points (p < 0.01 vs control and p < 0.05 vs omega-3, respectively). From the biochemical viewpoint, patients in the LD-1227 group showed a lower level of CRP, IL-6, TNF-α, IL-1β, CXCL1, IFNγ, IL-15 and IP-10 and significant downregulation of related gene expressions. Unlike what observed in LD-1227 group, in the omega-3 group, CRP and DAS28 did not reach statistical difference. A substantial reduction of extra pain killer use was noted under LD-1227 treatment. Conclusion. One can conclude that LD-1227 may play a significant role on the management of RA and with a specrum and mechanisms of actions distinct from the canonical omega-3 while being devoid of any side effect or tolerability issues.Keywords: rheumatoid arthritis, cytokines, omega-3, marine peptides, inflammation, pain, gene expression","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48284995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediterranean diet and health – a narrative review","authors":"V. Kaufman-Shriqui, D. A. Navarro, H. Salem, M. Boaz","doi":"10.31989/ffhd.v12i9.989","DOIUrl":"https://doi.org/10.31989/ffhd.v12i9.989","url":null,"abstract":"The Mediterranean Diet is a dietary pattern characterized by increased intake of olive oil, vegetables, fruits, cereals, nuts and pulses/legumes; as well as moderate intake of fish and other meat, dairy products and red wine. This dietary pattern has been associated with reduced risk for non-communicable diseases, including cardiovascular disease, type 2 diabetes mellitus, certain cancers, and dementia. The importance of modifying lifestyle risk factors to reduce these diseases is evidence by the increased obesity rates and aging of the global population. To examine associations between adherence to the Mediterranean Diet and non-communicable disease risk. There is evidence supporting a role for the Mediterranean Diet in primary and secondary non-communicable disease prevention; Furthermore, the Mediterranean Diet has been associated with reduced all-cause mortality.Conclusions: The Mediterranean Diet is associated with demonstrable and measurable health benefits, including non-communicable disease prevention and reduced mortality risk. The Mediterranean Diet is frequently consumed by individuals in Blue Zones.Keywords: Mediterranean diet; olive oil; non-communicable disease risk","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43079567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized, controlled trial on the effectiveness of a proprietary marine lipo-peptide formula vs omega-3 on cytokines profile, anxiety, and pain symptoms in patients with fibromyalgia","authors":"R. Rastmanesh, U. Solimene, A. Lorenzetti, F. Marotta, He Fang, Cristiana Aperio, Nevenka Anzulovic, Giuseppe Cervi, N. Zerbinati","doi":"10.31989/ffhd.v12i8.954","DOIUrl":"https://doi.org/10.31989/ffhd.v12i8.954","url":null,"abstract":"Objective: The aim of the present study in an RCT manner (physicians and patients) a novel lipo-peptide marine compound, LD-1227, on physical-, emotional- and functional-related symptomatic complaints in fibromyalgia patients as well as inflammatory cytokines profile and gene expression while using omega-3 as a control group.Methods: The following questionnaire-based or clinical evaluation-based parameters were evaluated: widespread pain index [WPI] patient global impression of change, total tender points [TTP], fibromyalgia impact questionnaire, Beck depression inventory, fatigue severity ratings, cognitive symptom severity, symptom severity score [SSS] and weekly pain intensity ratings. Additional biochemical and gene expression analysis of cytokines (IL6, TNF-α, IL-1β, MCP-1, IL-8, IL-13, IL-1α, and GM-CSF) was performed as well. Data were analyzed with either a paired t-test or the Wilcoxon signed rank test depending on the parametric or non-parametric distribution.Results: Comparing the data from before and after treatment for Group B indicated a statistically significant reduction (p=0.05) in TTP, WPI score, and SSS score. These data suggest a positive effect of a 3-month treatment with the LD-1227 but not omega-3 treatment on Fibromyalgia pain and related anxiety/depressive symptoms. Inspections of HRV and Cytokines found a statistically significant improvement after LD1227 treatment. Unlike the group supplemented with omega-3, the treatment with LD-1227 brought about a decrease in WPI and weekly pain intensity symptoms for the majority of participants. The pre-and post-treatment data for Group B indicated a statistically significant reduction (p=0.05) in TPC, WPI, and SSS scores. No adverse events were reported.Conclusion: These results provide the first indications that the LD-1227 treatment has a statistically significant effect on the recognized fibromyalgia diagnosis metrics of WPI, TTP, and SSS as well on inflammatory markers and parasympathetic balance.Keywords: fibromyalgia, marine compound, lipopeptide, cytokines, anxiety, pain, LD-1227.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69854075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of low lactose mare's milk yogurt consumption on gut microbiota function","authors":"Kozhakhmetov Samat, Muhanbetganov Nurislam, Pernebek Zhanel, Babenko Dmitriy, Tarzhanova Dinar, Uyzbaeva Indira, Khassenbekova Zhanagul, Zhantureyeva Akmaral, Jarmukhanov Zharkyn, Kozhakhmetova Saniya, Tultabayeva Tamara, Kushugulova Almagul","doi":"10.31989/ffhd.v12i8.981","DOIUrl":"https://doi.org/10.31989/ffhd.v12i8.981","url":null,"abstract":"Background: This study shows that the intake of low-lactose yogurt with the addition of mare's milk can affect the composition, biodiversity, and functional potential of the intestinal microflora.Purpose of the study: To study the effect of low-lactose drinking yogurt from a combination of mare's and cow's milk on the composition and functional repertoire of the fecal microbiota of rats.Methods: The study of the effect of low-lactose drinking yogurt from a combination of mare's and cow's milk on the intestinal microflora was carried out by dietary intervention for 4 weeks. Changes in the fecal microbiota were determined using V1-V3 sequencing of the hypervariable target region of the 16S rRNA gene. Functional prediction was carried out on the basis of the taxonomic structure of the amplicon sequence.Results: The results demonstrated a decrease in overall biodiversity both within the samples and between groups of animals. Discriminatory analysis revealed an increase in the relative content of Ruminococcaceae, Peptostreptococcaceae, indeterminate taxon at phylum level, Prevotellaceae and a decrease in Helicobacteraceae, Eubacteriumcoprostanoligenes group, Muribaculaceae, Lachnospiraceae, Lactobacillaceae. In addition, changes in the microbial structure also affected the predicted functional repertoire of the gut microbiota.Conclusion: These results demonstrate the consumption of low-lactose drinking yogurt from a combination of mare's and cow's milk, for a short time, can affect the composition and functional repertoire of the fecal microbiota. Keywords: Gut microbiome, rats, low-lactose yogurt, microbial diversity, functional repertoire.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45219850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of spinach-derived glutathione against carbon tetrachloride-induced stress in rats","authors":"Enas Abdulkareem Abdulrazak, Oaswaa Yousif Jameel","doi":"10.31989/ffhd.v12i8.972","DOIUrl":"https://doi.org/10.31989/ffhd.v12i8.972","url":null,"abstract":" Background: Increased consumption of natural antioxidants found in vegetables and fruits has been linked to a lower risk of disease caused by oxidative stress.Objective: The current study's focus was to compare the antioxidant properties of synthetic glutathione and glutathione derived from spinach against CCl4-induced stress in female albino rats. Materials and Methods: Cold chloroform extraction was used to prepare the spinach leaf extract. Glutathione was then extracted from the spinach leaf extract using preparative HPLC afterward when the concentration of glutathione was measured in the extract. Biological preventive and therapeutic experiments were conducted, where laboratory rats were divided into 6 groups, the first group G1 (positive control group), the second group G2 (negative control group), the third group G3 preventive experiment 1 (group glutathione extracted from spinach + CCl4), the fourth group G4 therapeutic experiment 1 (Group CCl4+ Glutathione extracted from spinach), the fifth group G5 Preventive experiment 2 (Group of synthetic glutathione + CCl4), the sixth group G6 therapeutic experiment 2 (Group CCl4+ Glutathione extracted from spinach). Results: Treatment of rats with spinach-derived synthetic glutathione, before or after they were given CCl4 subcutaneous, improved the values of parameters near to normal levels in the positive control animals in groups treated with spinach-derived glutathione (G3 and G4) compared to treatment with synthetic glutathione (G5 and G6). Administration of milk with glutathione derived from Iraqi spinach leaves exhibited favorable effects on oxidative stress, greatly enhanced the antioxidant system, and protected rats from liver damage brought on by carbon tetrachloride compared to milk with synthetic glutathione. Keywords: Iraqi spinach, Functional food, Natural antioxidant, Oxidative stress, synthetic glutathione. ","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46760155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of the health benefits of Strychnos decussata (Pappe) Gilg (Loganiaceae): a potential functional food","authors":"A. Maroyi","doi":"10.31989/ffhd.v12i8.984","DOIUrl":"https://doi.org/10.31989/ffhd.v12i8.984","url":null,"abstract":"Strychnos decussata is a small to medium sized tree which naturally occurs in open-wooded and thickets in tropical Africa. A critical appraisal of the medicinal, pharmacological and socio-economic properties of S. decussata are provided. Research articles focusing on the medicinal, pharmacological and socio-economic properties of S. decussata were searched from online databases such as Google Scholar, PubMed, Science Direct, SciELO and SpringerLink. No time limit was set for the search and all research outputs that aligned with the scope of the review were included. S. decussata has diverse uses as a food plant and also has medicinal uses such as charm and ritual, scorpion and snake bite antidote, ethnoveterinary medicine, and traditional medicine for fever, gastro-intestinal problems, headache, respiratory infections, wounds, venereal diseases and infections. S. decussata exert biological activities such as antifungal, antimycobacterial, antiplasmodial and convulsant activities. Several phytochemical compounds such as decussine and decussine-type alkaloids, gluco-indole alkaloids and pentacyclic indole alkaloids have been isolated from the species. Many applications of S. decussata as source of food and herbal medicines as well as its phytochemistry and pharmarcological properties need further investigations.Keywords: Buddleia family, ethnomedicinal uses, indigenous knowledge, Loganiaceae, Strychnos decussata","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46990692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}