D. Bagchi, B. Downs, S. Banik, M. Bagchi, S. Kushner, Sanjoy Chakraborty, Bruce S. Morrison, S. Hesson
Background: The prevalence of obesity has increased an astounding 30.5% to 42.2% over the last two decades despite numerous weight loss products and programs, thus qualifying it as an epidemic. Fat is the lightest of macromolecules, the highest energy reserve of the body, and the last reservoir of survival insurance to be expended. Water, muscle, and electrolytes are diminished prior to the expenditure of fat resources, the primary cause of rapid weight loss. Contrary to popular belief that only “weight gain” is the sole and correct parameter for evaluating healthy body recomposition, there are no less than 10 additional factors that contribute to a reduction in metabolic rate and an increase in fat storage. These are mostly ignored from considerations regarding the etiology of obesity. Our laboratory developed a novel formulation of D-ribose nicotinamide, alpha glycerol phosphorylcholine and four other evidence-based botanical constituents encapsulated in a Prodosomed stimulant- and sugar-free TRCAP21 (TrimRoxTM) formulation that effectively addresses those contributing factors. To investigate the feasibility of doing a 90-day randomized, double-blind placebo-controlled investigation, we conducted a 21-day concept validation pilot study on TRCAP21 in 9 subjects to assess changes in various body parts, including chest, upper arms, waist/belly, hips, and thighs, as well as body weight. Objective: This physician-supervised 21-day concept validation pilot study on TRCAP21 was conducted on 9 subjects to determine changes in anthropometric parameters including chest, upper arms, waist/belly, hips, and thighs, as well as body weight, and determine the effect of TRCAP21 on energy, mood, satiety, and sugar cravings.Materials and Methods: The study was conducted on nine male and female subjects (age: 47-70 years) to assess the efficacy of TrimRoxTM over a period of 21 consecutive days. Body weights and anthropometric measurements were conducted at the initiation and termination of the study. The effect of TRCAP21 was evaluated on energy level, mood elevation, satiety level, sugar cravings, overall health, and adverse events in the subjects.Results: The results demonstrated that all subjects experienced a reduction in size of one or more these body parts. In addition, it also led to significant improvements in mood elevation, satiety, reduced sugar cravings, elevated energy levels and overall mental and physical health. Intake of 1 packet twice a day (BID) before meals resulted in a significantly greater reduction of body measurements than consuming it once a day (OID). Surprisingly, body weight was reduced in all nine subjects from 2 lbs. to 11 lbs. The randomized double-blind placebo-controlled study is underway to confirm and further substantiate these findings. Conclusion: The TRCAP21 Prodosomed nutraceutical formulation combines the evidence-based efficacy of 6 key constituents, mostly of botanical origin, that act synergistically to restore aerobic
{"title":"Effective body recomposition vs. misconceptions of the traditional weight loss strategies: TRCAP21 - a novel technological breakthrough in body recomposition","authors":"D. Bagchi, B. Downs, S. Banik, M. Bagchi, S. Kushner, Sanjoy Chakraborty, Bruce S. Morrison, S. Hesson","doi":"10.31989/ffhd.v12i4.905","DOIUrl":"https://doi.org/10.31989/ffhd.v12i4.905","url":null,"abstract":"Background: The prevalence of obesity has increased an astounding 30.5% to 42.2% over the last two decades despite numerous weight loss products and programs, thus qualifying it as an epidemic. Fat is the lightest of macromolecules, the highest energy reserve of the body, and the last reservoir of survival insurance to be expended. Water, muscle, and electrolytes are diminished prior to the expenditure of fat resources, the primary cause of rapid weight loss. Contrary to popular belief that only “weight gain” is the sole and correct parameter for evaluating healthy body recomposition, there are no less than 10 additional factors that contribute to a reduction in metabolic rate and an increase in fat storage. These are mostly ignored from considerations regarding the etiology of obesity. Our laboratory developed a novel formulation of D-ribose nicotinamide, alpha glycerol phosphorylcholine and four other evidence-based botanical constituents encapsulated in a Prodosomed stimulant- and sugar-free TRCAP21 (TrimRoxTM) formulation that effectively addresses those contributing factors. To investigate the feasibility of doing a 90-day randomized, double-blind placebo-controlled investigation, we conducted a 21-day concept validation pilot study on TRCAP21 in 9 subjects to assess changes in various body parts, including chest, upper arms, waist/belly, hips, and thighs, as well as body weight. Objective: This physician-supervised 21-day concept validation pilot study on TRCAP21 was conducted on 9 subjects to determine changes in anthropometric parameters including chest, upper arms, waist/belly, hips, and thighs, as well as body weight, and determine the effect of TRCAP21 on energy, mood, satiety, and sugar cravings.Materials and Methods: The study was conducted on nine male and female subjects (age: 47-70 years) to assess the efficacy of TrimRoxTM over a period of 21 consecutive days. Body weights and anthropometric measurements were conducted at the initiation and termination of the study. The effect of TRCAP21 was evaluated on energy level, mood elevation, satiety level, sugar cravings, overall health, and adverse events in the subjects.Results: The results demonstrated that all subjects experienced a reduction in size of one or more these body parts. In addition, it also led to significant improvements in mood elevation, satiety, reduced sugar cravings, elevated energy levels and overall mental and physical health. Intake of 1 packet twice a day (BID) before meals resulted in a significantly greater reduction of body measurements than consuming it once a day (OID). Surprisingly, body weight was reduced in all nine subjects from 2 lbs. to 11 lbs. The randomized double-blind placebo-controlled study is underway to confirm and further substantiate these findings. Conclusion: The TRCAP21 Prodosomed nutraceutical formulation combines the evidence-based efficacy of 6 key constituents, mostly of botanical origin, that act synergistically to restore aerobic","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":"60 4","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41303094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rehab O. Elnour, Omar Musa EzzEldin, ABDALBASIT ADAM MARIOD, R. Ahmed, A. S. Eltahir
Background: In fact, diabetes is now a serious health concern, and the import of medications from other countries consumes a significant amount of foreign cash each year. The effects of Raphanus satives (Radish) in the treatment of diabetes mellitus were evaluated scientifically in this study. Thyroid hormone increases metabolic actions in almost every tissue, and the current study was an attempt to evaluate scientifically the effects of Raphanus satives (Radish) in the treatment of diabetes mellitus.Objectives: The main objective of this study is to evaluate the hypoglycemic effect of Raphanus sativus (Radish) on induced hyperglycemic rats.Methods: An oral administration of ethanolic extract of Radish in glucose loaded rats at dose of 250mg/k body weight, standard group was administered with 10mg/kg of hypoglycemic drug glibenclamide for 2 consecutive weeks. The control group was given distilled water only. After the two weeks' time, the groups were subjected to a glucose tolerance test and measurement of plasma cholesterol and triglyceride levels. Results: significant reduction of blood glucose was observed (P <0.001), when compared with the control group at 2 hours after glucose loud. Radish ethanolic extract did not present any significant difference in cholesterol level after 2 weeks compared with start point. No significant difference was seen in triglyceride level after 2 weeks of administration of Radish extract compared with start point. Radish extract(250 mg/kg) did not affect kidney function creatinin and urea, also liver function were not affected Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-Pyruvate Transaminase (GPT), albumin, total protein and bilirubin, this means administration of increased doses to hyperglycemic subjects can be considered safe. CONCLUSION: In this investigation, doses of radish extract (250 mg/kg) had no effect on renal function, creatinin, and urea, as well as liver function. Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-Pyruvate Transaminase (GPT), albumin, total protein, and bilirubin .Keywords: Raphanus sativus, extract, hypoglycemic, glucose, rats
{"title":"Effect of Raphanus sativus on Glucose, Cholesterol and Triglycerides Levels in Glucose Loaded Rats","authors":"Rehab O. Elnour, Omar Musa EzzEldin, ABDALBASIT ADAM MARIOD, R. Ahmed, A. S. Eltahir","doi":"10.31989/ffhd.v12i3.883","DOIUrl":"https://doi.org/10.31989/ffhd.v12i3.883","url":null,"abstract":"Background: In fact, diabetes is now a serious health concern, and the import of medications from other countries consumes a significant amount of foreign cash each year. The effects of Raphanus satives (Radish) in the treatment of diabetes mellitus were evaluated scientifically in this study. Thyroid hormone increases metabolic actions in almost every tissue, and the current study was an attempt to evaluate scientifically the effects of Raphanus satives (Radish) in the treatment of diabetes mellitus.Objectives: The main objective of this study is to evaluate the hypoglycemic effect of Raphanus sativus (Radish) on induced hyperglycemic rats.Methods: An oral administration of ethanolic extract of Radish in glucose loaded rats at dose of 250mg/k body weight, standard group was administered with 10mg/kg of hypoglycemic drug glibenclamide for 2 consecutive weeks. The control group was given distilled water only. After the two weeks' time, the groups were subjected to a glucose tolerance test and measurement of plasma cholesterol and triglyceride levels. Results: significant reduction of blood glucose was observed (P <0.001), when compared with the control group at 2 hours after glucose loud. Radish ethanolic extract did not present any significant difference in cholesterol level after 2 weeks compared with start point. No significant difference was seen in triglyceride level after 2 weeks of administration of Radish extract compared with start point. Radish extract(250 mg/kg) did not affect kidney function creatinin and urea, also liver function were not affected Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-Pyruvate Transaminase (GPT), albumin, total protein and bilirubin, this means administration of increased doses to hyperglycemic subjects can be considered safe. CONCLUSION: In this investigation, doses of radish extract (250 mg/kg) had no effect on renal function, creatinin, and urea, as well as liver function. Glutamic-Oxaloacetic Transaminase (GOT), Glutamic-Pyruvate Transaminase (GPT), albumin, total protein, and bilirubin .Keywords: Raphanus sativus, extract, hypoglycemic, glucose, rats ","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49590515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Jippo, Yuko Kobayashi, Kousuke Kitada, Kitsuda Koji
Introduction: The incidences of allergic diseases such as allergic rhinitis, atopic dermatitis, asthma, and food allergies are rising in developed countries. Mast cells play critical roles in various biologic processes related to allergic diseases, including expressing the high-affinity receptor for immunoglobulin (Ig) E on their surface. The interaction of multivalent antigens with surface-bound IgE causes the secretion of granule-stored mediators, as well as the de novo synthesis of cytokines. These mediators and cytokines precede the development of allergic diseases. In Osaka Prefecture, Japan, certain locally cultivated crops have received ‘Naniwa-yasai’, a designation that certifies the significance of traditional vegetables in supporting Osaka’s agriculture and cuisine for over a century. In this study, we investigated the anti-allergic effects of four traditional vegetables from Osaka.Results: The anti-allergic activity of extracts made from Tanabe radish, Moriguchi radish, bunching onion (Allium fistulosum), and mizu eggplant were examined. Various concentrations of each extract were added to RBL-2H3 mast cells prior to stimulation with the calcium ionophore A23187. β-hexosaminidase release was markedly and dose dependently decreased in mast cells following the addition of A. fistulosum, demonstrating its anti-allergic activity. None of the other vegetables had an anti-allergic effect on RBL-2H3 cells.Conclusion: An Osakan traditional vegetable, bunching onion (Allium fistulosum), exhibited anti-allergic activity, and should be explored further as a possible treatment for allergic diseases.Keywords: mast cell, anti-allergy, traditional vegetables, bunching onion (Allium fistulosum)
{"title":"Anti-allergic activity of an ethanol extract of bunching onion (Allium fistulosum), a traditional vegetable from Osaka","authors":"T. Jippo, Yuko Kobayashi, Kousuke Kitada, Kitsuda Koji","doi":"10.31989/ffhd.v12i3.900","DOIUrl":"https://doi.org/10.31989/ffhd.v12i3.900","url":null,"abstract":"Introduction: The incidences of allergic diseases such as allergic rhinitis, atopic dermatitis, asthma, and food allergies are rising in developed countries. Mast cells play critical roles in various biologic processes related to allergic diseases, including expressing the high-affinity receptor for immunoglobulin (Ig) E on their surface. The interaction of multivalent antigens with surface-bound IgE causes the secretion of granule-stored mediators, as well as the de novo synthesis of cytokines. These mediators and cytokines precede the development of allergic diseases. In Osaka Prefecture, Japan, certain locally cultivated crops have received ‘Naniwa-yasai’, a designation that certifies the significance of traditional vegetables in supporting Osaka’s agriculture and cuisine for over a century. In this study, we investigated the anti-allergic effects of four traditional vegetables from Osaka.Results: The anti-allergic activity of extracts made from Tanabe radish, Moriguchi radish, bunching onion (Allium fistulosum), and mizu eggplant were examined. Various concentrations of each extract were added to RBL-2H3 mast cells prior to stimulation with the calcium ionophore A23187. β-hexosaminidase release was markedly and dose dependently decreased in mast cells following the addition of A. fistulosum, demonstrating its anti-allergic activity. None of the other vegetables had an anti-allergic effect on RBL-2H3 cells.Conclusion: An Osakan traditional vegetable, bunching onion (Allium fistulosum), exhibited anti-allergic activity, and should be explored further as a possible treatment for allergic diseases.Keywords: mast cell, anti-allergy, traditional vegetables, bunching onion (Allium fistulosum)","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44316362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Shiojima, Megumi Takahashi, Ryohei Takahashi, H. Moriyama, Kazuo Maruyama, D. Bagchi, M. Bagchi
Background: In advancing age population worldwide, joint discomfort and poor locomotive functions are symptoms, which are often detected. Aggravation of such symptoms potentially develops into osteoarthritis (OA) as characterized by the loss of articular cartilage in the joints of the hand, spine, knee, foot, and hip. For joint health complications, selected functional foods are frequently supplemented orally to alleviate such symptoms. In Japan, Foods with Function Claims (FFC) regulatory system is now positioned within the framework of “so-called health foods” allowing to make functional claims such as brain health and weight control claims. Moreover, a wide variety of knee joint care FFC products are presently available in the marketplace and have attracted much attention of the elderly people, expecting improvements in joint locomotive functions such as walking, sitting, standing, and climbing the stairs for the quality of life (QOL). Supplementation of undenatured type II collagen powder (NEXT-II®) in hard capsules has been clinically proven to improve such joint functions fulfilling part of the FFC rigorous guidelines, while ensuring adequate safety as foods is a crucial prerequisite for filing FFC product dossier.Methods: Twenty-two healthy male and female volunteers (age = 20-74 years) participated in this pilot open-label overdose clinical trial over a period of 4 consecutive weeks. All subjects were also monitored and assessed additional 2 weeks after the completion of the NEXT-II® supplementation period as washout or supplement-free period. Subjects took a 10-fold (10-X) dose of NEXT-II® (400 mg NEXT-II/day containing 32 mg of undenatured type II collagen/day). Daily recommended dose of NEXT-II® is 40 mg/day (containing 3.2 mg of undenatured type II collagen/day) after breakfast. Physical health examination, hematological analysis, blood ,biochemistry examination, and urinalysis were performed. All subjects completed the supplementation of NEXT-II® for 4 weeks and had additional 2 weeks of washout or supplement-free period. All subjects recorded daily diaries. Results: Results demonstrated no significant differences at 0 week (baseline), 2 weeks, and 4 weeks of NEXT-II®supplementation. Furthermore, no significant differences were observed even after 2 weeks of the washout period. No adverse events were observed.Conclusions: Supplementation of 10-fold dose of NEXT-II® to the volunteers was well-tolerated and exhibited the broad-spectrum safety without observing any adverse effects in healthy Japanese subjects.Keywords: Undenatured type II collagen, NEXT-II®, Safety, Overdose supplementation, Clinical study, Foods with Function Claims (FFC)
{"title":"Safety of Dietary Undenatured Type II Collagen: A Pilot Open-Label Overdose Clinical Investigation","authors":"Y. Shiojima, Megumi Takahashi, Ryohei Takahashi, H. Moriyama, Kazuo Maruyama, D. Bagchi, M. Bagchi","doi":"10.31989/ffhd.v12i3.897","DOIUrl":"https://doi.org/10.31989/ffhd.v12i3.897","url":null,"abstract":"Background: In advancing age population worldwide, joint discomfort and poor locomotive functions are symptoms, which are often detected. Aggravation of such symptoms potentially develops into osteoarthritis (OA) as characterized by the loss of articular cartilage in the joints of the hand, spine, knee, foot, and hip. For joint health complications, selected functional foods are frequently supplemented orally to alleviate such symptoms. In Japan, Foods with Function Claims (FFC) regulatory system is now positioned within the framework of “so-called health foods” allowing to make functional claims such as brain health and weight control claims. Moreover, a wide variety of knee joint care FFC products are presently available in the marketplace and have attracted much attention of the elderly people, expecting improvements in joint locomotive functions such as walking, sitting, standing, and climbing the stairs for the quality of life (QOL). Supplementation of undenatured type II collagen powder (NEXT-II®) in hard capsules has been clinically proven to improve such joint functions fulfilling part of the FFC rigorous guidelines, while ensuring adequate safety as foods is a crucial prerequisite for filing FFC product dossier.Methods: Twenty-two healthy male and female volunteers (age = 20-74 years) participated in this pilot open-label overdose clinical trial over a period of 4 consecutive weeks. All subjects were also monitored and assessed additional 2 weeks after the completion of the NEXT-II® supplementation period as washout or supplement-free period. Subjects took a 10-fold (10-X) dose of NEXT-II® (400 mg NEXT-II/day containing 32 mg of undenatured type II collagen/day). Daily recommended dose of NEXT-II® is 40 mg/day (containing 3.2 mg of undenatured type II collagen/day) after breakfast. Physical health examination, hematological analysis, blood ,biochemistry examination, and urinalysis were performed. All subjects completed the supplementation of NEXT-II® for 4 weeks and had additional 2 weeks of washout or supplement-free period. All subjects recorded daily diaries. Results: Results demonstrated no significant differences at 0 week (baseline), 2 weeks, and 4 weeks of NEXT-II®supplementation. Furthermore, no significant differences were observed even after 2 weeks of the washout period. No adverse events were observed.Conclusions: Supplementation of 10-fold dose of NEXT-II® to the volunteers was well-tolerated and exhibited the broad-spectrum safety without observing any adverse effects in healthy Japanese subjects.Keywords: Undenatured type II collagen, NEXT-II®, Safety, Overdose supplementation, Clinical study, Foods with Function Claims (FFC)","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45721417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Uma Bansal, A. Bhardwaj, S. Singh, Sucheta Khubber, Nitya Sharma, Vasudha Bansal
AbstractBackground: Plant-based quercetin is usually produced using fruit and vegetable wastes and is sold in the market in powdered form. Since it is already used as a supplement in various foods, therefore, a study was conducted to develop calorie rich nutrition bars using plant-based quercetin, that may serve as a promising functional snack with high antioxidant property for general consumption by teenagers, adults, athletes and sports persons. To surmise, this study deals with the development of a novel nutrition bar by utilizing a plant byproduct.Methods: Plant based pure quercetin extract powder (98% Premium grade) was procured from HerbaDiet, Arkure Health Care, Rohtak, Haryana (India). Other materials used were: quinoa (Chenopodium quinoa) (Pro nature Organic Foods Pvt. Ltd.); instant white oats (Kellogg’s India Pvt. Ltd., New Delhi); canola oil (Jivo Wellness Pvt. Ltd.); jaggery (Village product industries); nuts- comprising almond, cashew, walnut, roasted & salted pistachios (Happilo International Pvt. Ltd.).Objective: The study was carried out in order to formulate calorie and nutrient rich bars for all the age-groups with a prime focus on antioxidant-quercetin. Results: Quercetin-based nutrition bar was developed with different levels of quercetin (0, 20, 40, 60, 80 mg 100g-1), in addition to other ingredients including oats, quinoa, nuts, canola oil and jaggery. Addition of quercetin showed a significant (p ≤ 0.05) change on its water activity, color and textural attributes. With the increase in the quercetin content, a significant decrease in the water activity and increase in the lightness (L*) and hardness values of nutrition bar samples was observed. The quercetin enriched nutrition bars also showed an increase in total phenolic content as well as antioxidant capacity, as assessed by DPPH radical scavenging activity. Evaluation of overall acceptability and sensory profiling was done for all samples and the one with 60 mg 100g-1 quercetinqualified as the best in sensorial attributes.The main finding: The results revealed that quercetin-based nutrition bar can be a palatable and promising functional food with high antioxidant property.
摘要背景：植物性槲皮素通常使用水果和蔬菜废料生产，并以粉末形式在市场上出售。由于它已经被用作各种食品的补充剂，因此，研究了使用植物性槲皮素开发富含热量的营养棒，这可能是一种很有前途的具有高抗氧化性能的功能性零食，供青少年、成年人、运动员和运动人士食用。可以推测，本研究利用植物副产品开发了一种新型营养棒。方法：从印度哈里亚纳邦Rohtak Arkure Health Care的HerbaDiet采购植物纯槲皮素提取物粉末（98%优质）。使用的其他材料有：藜麦（Chenopodium quinoa）（Pro-nature Organic Foods Pvt.有限公司）；速溶白燕麦（Kellogg's India Pvt.有限公司，新德里）；菜籽油（Jivo Wellness Pvt.有限公司）；jaggery（乡村产品工业）；由杏仁、腰果、胡桃、烤和腌开心果组成的坚果（Happilo International Pvt.有限公司）。结果：以槲皮素为基础的营养棒含有不同水平的槲皮素（0、20、40、60、80 mg 100g-1），此外还有燕麦、藜麦、坚果、菜籽油和果酱等其他成分。槲皮素的添加对其水分活性、颜色和质地特性有显著影响（p≤0.05）。随着槲皮素含量的增加，营养棒样品的水分活性显著降低，亮度（L*）和硬度值增加。通过DPPH自由基清除活性评估，富含槲皮素的营养棒还显示出总酚含量和抗氧化能力的增加。对所有样品的总体可接受性和感官特征进行了评估，其中含有60mg 100g-1槲皮素的样品被鉴定为感官特性最佳。主要研究结果表明：槲皮素营养棒是一种适口性强、抗氧化性能好的功能性食品。
{"title":"Effect of incorporating plant-based quercetin on physicochemical properties, consumer acceptability and sensory profiling of nutrition bars","authors":"Uma Bansal, A. Bhardwaj, S. Singh, Sucheta Khubber, Nitya Sharma, Vasudha Bansal","doi":"10.31989/ffhd.v12i3.888","DOIUrl":"https://doi.org/10.31989/ffhd.v12i3.888","url":null,"abstract":"AbstractBackground: Plant-based quercetin is usually produced using fruit and vegetable wastes and is sold in the market in powdered form. Since it is already used as a supplement in various foods, therefore, a study was conducted to develop calorie rich nutrition bars using plant-based quercetin, that may serve as a promising functional snack with high antioxidant property for general consumption by teenagers, adults, athletes and sports persons. To surmise, this study deals with the development of a novel nutrition bar by utilizing a plant byproduct.Methods: Plant based pure quercetin extract powder (98% Premium grade) was procured from HerbaDiet, Arkure Health Care, Rohtak, Haryana (India). Other materials used were: quinoa (Chenopodium quinoa) (Pro nature Organic Foods Pvt. Ltd.); instant white oats (Kellogg’s India Pvt. Ltd., New Delhi); canola oil (Jivo Wellness Pvt. Ltd.); jaggery (Village product industries); nuts- comprising almond, cashew, walnut, roasted & salted pistachios (Happilo International Pvt. Ltd.).Objective: The study was carried out in order to formulate calorie and nutrient rich bars for all the age-groups with a prime focus on antioxidant-quercetin. Results: Quercetin-based nutrition bar was developed with different levels of quercetin (0, 20, 40, 60, 80 mg 100g-1), in addition to other ingredients including oats, quinoa, nuts, canola oil and jaggery. Addition of quercetin showed a significant (p ≤ 0.05) change on its water activity, color and textural attributes. With the increase in the quercetin content, a significant decrease in the water activity and increase in the lightness (L*) and hardness values of nutrition bar samples was observed. The quercetin enriched nutrition bars also showed an increase in total phenolic content as well as antioxidant capacity, as assessed by DPPH radical scavenging activity. Evaluation of overall acceptability and sensory profiling was done for all samples and the one with 60 mg 100g-1 quercetinqualified as the best in sensorial attributes.The main finding: The results revealed that quercetin-based nutrition bar can be a palatable and promising functional food with high antioxidant property.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41797589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shiori Takano, Kazuma Yoshizumi, Hitomi Kobayashi, N. Iwamoto, Masaki Taga
Background: It has been confirmed that the daily consumption of seaweed such as Wakame (Undaria pinnatifida) and Kombu (Saccharina japonica) has an inhibitory effect on the rise in postprandial blood glucose levels. Similar effects can also be expected for Mekabu, which is Wakame sporophylls and contains large quantities of water-soluble dietary fiber. In this study, we examined the effects of preprandial intake of Mekabu on postprandial blood glucose levels and blood glucose regulation-related hormones in healthy young women.Methods: The subjects were ten healthy young adult women. Mekabu was eaten, followed by rice only. Blood was sampled five times: while fasting (0 min), and 15, 30, 90, and 120 minutes after eating. Measurements were taken of blood glucose level and blood glucose regulation-related hormones.Result: Eating Mekabu before rice resulted in a significant reduction of Δglucose and Δinsulin at 30 minutes after ingestion (p = 0.034, p = 0.049, respectively). The concentration of glucagon-like peptide-1 (GLP-1) in plasma was higher 30 minutes after eating (p = 0.044), 60 minutes (p = 0.0.31), and 120 minutes (p = 0.019) when Mekabu was eaten preprandially.Conclusions: In the present study, GLP-1 secretion was sustained by eating Mekabu, which is Wakame sporophylls, before rice. Our results suggest that ingesting Mekabu, which contains large amounts of viscous alginic acid, prior to a meal not only suppresses postprandial blood glucose level, but supports the extended secretion of GLP-1, providing a sustainable incretin effect.
{"title":"Suppression of blood glucose level elevation and promotion of GLP-1 secretion by ingestion of Undaria pinnatifida sporophylls (Mekabu): Open-label crossover design","authors":"Shiori Takano, Kazuma Yoshizumi, Hitomi Kobayashi, N. Iwamoto, Masaki Taga","doi":"10.31989/ffhd.v12i2.891","DOIUrl":"https://doi.org/10.31989/ffhd.v12i2.891","url":null,"abstract":"Background: It has been confirmed that the daily consumption of seaweed such as Wakame (Undaria pinnatifida) and Kombu (Saccharina japonica) has an inhibitory effect on the rise in postprandial blood glucose levels. Similar effects can also be expected for Mekabu, which is Wakame sporophylls and contains large quantities of water-soluble dietary fiber. In this study, we examined the effects of preprandial intake of Mekabu on postprandial blood glucose levels and blood glucose regulation-related hormones in healthy young women.Methods: The subjects were ten healthy young adult women. Mekabu was eaten, followed by rice only. Blood was sampled five times: while fasting (0 min), and 15, 30, 90, and 120 minutes after eating. Measurements were taken of blood glucose level and blood glucose regulation-related hormones.Result: Eating Mekabu before rice resulted in a significant reduction of Δglucose and Δinsulin at 30 minutes after ingestion (p = 0.034, p = 0.049, respectively). The concentration of glucagon-like peptide-1 (GLP-1) in plasma was higher 30 minutes after eating (p = 0.044), 60 minutes (p = 0.0.31), and 120 minutes (p = 0.019) when Mekabu was eaten preprandially.Conclusions: In the present study, GLP-1 secretion was sustained by eating Mekabu, which is Wakame sporophylls, before rice. Our results suggest that ingesting Mekabu, which contains large amounts of viscous alginic acid, prior to a meal not only suppresses postprandial blood glucose level, but supports the extended secretion of GLP-1, providing a sustainable incretin effect.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45220115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Sakaguchi, T. Okuyama, M. Kotsuka, T. Yoshida, T. Okumura, M. Nishizawa, M. Kaibori, Mitsugu Sekimoto
Background: Sokeikakketsuto (SOK) is a Kampo medicine that can mitigate several types of pain, including arthralgia, neuralgia, low back pain, and myalgia, which may be introduced for the treatment of neuropathic pain in anti-cancer therapy. Considering that several Kampo medicines are known to have hepatoprotective and anti-inflammatory effects, we investigated the pharmacological mechanism of SOK in hepatocytes. Additionally, we examined another Kampo medicine, makyoyokukanto (MAK), as a reference as it has been reported to have similar efficacy for neuropathic pain.Methods: SOK or MAK was incubated with rat primary cultured hepatocytes treated with interleukin (IL)-1β. The induction of inducible nitric oxide synthase (iNOS), nitric oxide (NO) production, iNOS signaling pathways, and the expression of other inflammatory mediators was investigated.Results: IL-1β activated iNOS induction, followed by NO production. SOK and MAK reduced the expression of iNOS mRNA and its protein and decreased NO production. SOK and MAK also decreased the levels of tumor necrosis factor (TNF)-α and increased the levels of IL-6 and IL-1β. Transfection experiments with iNOS promoter-luciferase constructs revealed that MAK reduced iNOS mRNA synthesis and stability; however, SOK only reduced mRNA synthesis. Both medicines suppressed the activation of nuclear factor (NF)-κB but did not block the upregulation of type I IL-1 receptor in two essential signaling pathways.Conclusions: SOK and MAK could prevent NO production by inhibiting iNOS gene expression, partly through NF-κB activation, in inflamed hepatocytes. However, both medicines may have different mechanisms of action in the treatment of injured organs.
{"title":"Hepatoprotective and anti-inflammatory profile of sokeikakketsuto and makyoyokukanto in primary cultured rat hepatocytes","authors":"T. Sakaguchi, T. Okuyama, M. Kotsuka, T. Yoshida, T. Okumura, M. Nishizawa, M. Kaibori, Mitsugu Sekimoto","doi":"10.31989/ffhd.v12i2.887","DOIUrl":"https://doi.org/10.31989/ffhd.v12i2.887","url":null,"abstract":"Background: Sokeikakketsuto (SOK) is a Kampo medicine that can mitigate several types of pain, including arthralgia, neuralgia, low back pain, and myalgia, which may be introduced for the treatment of neuropathic pain in anti-cancer therapy. Considering that several Kampo medicines are known to have hepatoprotective and anti-inflammatory effects, we investigated the pharmacological mechanism of SOK in hepatocytes. Additionally, we examined another Kampo medicine, makyoyokukanto (MAK), as a reference as it has been reported to have similar efficacy for neuropathic pain.Methods: SOK or MAK was incubated with rat primary cultured hepatocytes treated with interleukin (IL)-1β. The induction of inducible nitric oxide synthase (iNOS), nitric oxide (NO) production, iNOS signaling pathways, and the expression of other inflammatory mediators was investigated.Results: IL-1β activated iNOS induction, followed by NO production. SOK and MAK reduced the expression of iNOS mRNA and its protein and decreased NO production. SOK and MAK also decreased the levels of tumor necrosis factor (TNF)-α and increased the levels of IL-6 and IL-1β. Transfection experiments with iNOS promoter-luciferase constructs revealed that MAK reduced iNOS mRNA synthesis and stability; however, SOK only reduced mRNA synthesis. Both medicines suppressed the activation of nuclear factor (NF)-κB but did not block the upregulation of type I IL-1 receptor in two essential signaling pathways.Conclusions: SOK and MAK could prevent NO production by inhibiting iNOS gene expression, partly through NF-κB activation, in inflamed hepatocytes. However, both medicines may have different mechanisms of action in the treatment of injured organs.","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46861798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABDALBASIT ADAM MARIOD, E. M. A. Mustafa, Marwa Bushra Yahia
Background: Monechma ciliatum (MC) (Acanthaceae family) is a herb that grows in tropical and subtropical regions. It grows with small, brownish-black seeds. This is why the Sudanese people call it the “black mahlab”. This plant is primarily used in traditional meals, as well as the production of medical treatments and perfumes. Additionally, the seeds of the Monechma ciliatum plant are rich in fats, proteins, minerals, and other essential nutrients. It also functions as an effective laxative. As a result, this plant is commonly found as a supplement in cereal to enrich nutritional value. This review explores the nutritive value, antioxidants, antimicrobial, medicinal, cosmeceutical, and oxytocic properties of Monechma ciliatum seeds, leaves, and stem. To prepare this review, we researched published scientific literature by using the following keywords: “Monechma”, “Antioxidants”, “Antimicrobial”, nutritional”, “Monechma ciliatum”, “Monechma phenolics”. Our search was carried out in PubMed and Google Scholar databases and included original research from the past 25 years in English only. A total number of 50 original papers, which mentioned the phytochemistry, nutritional, biological, and medicinal properties of Monechma ciliatum were selected and considered for this review. Keywords: Monechma ciliatum, black mahlab, nutritional, antioxidants, Antimicrobial, oxytocic
{"title":"A review on the health benefits of Monechma ciliatum (Black mahlab): A potential functional food","authors":"ABDALBASIT ADAM MARIOD, E. M. A. Mustafa, Marwa Bushra Yahia","doi":"10.31989/ffhd.v12i2.879","DOIUrl":"https://doi.org/10.31989/ffhd.v12i2.879","url":null,"abstract":"Background: Monechma ciliatum (MC) (Acanthaceae family) is a herb that grows in tropical and subtropical regions. It grows with small, brownish-black seeds. This is why the Sudanese people call it the “black mahlab”. This plant is primarily used in traditional meals, as well as the production of medical treatments and perfumes. Additionally, the seeds of the Monechma ciliatum plant are rich in fats, proteins, minerals, and other essential nutrients. It also functions as an effective laxative. As a result, this plant is commonly found as a supplement in cereal to enrich nutritional value. This review explores the nutritive value, antioxidants, antimicrobial, medicinal, cosmeceutical, and oxytocic properties of Monechma ciliatum seeds, leaves, and stem. To prepare this review, we researched published scientific literature by using the following keywords: “Monechma”, “Antioxidants”, “Antimicrobial”, nutritional”, “Monechma ciliatum”, “Monechma phenolics”. Our search was carried out in PubMed and Google Scholar databases and included original research from the past 25 years in English only. A total number of 50 original papers, which mentioned the phytochemistry, nutritional, biological, and medicinal properties of Monechma ciliatum were selected and considered for this review. Keywords: Monechma ciliatum, black mahlab, nutritional, antioxidants, Antimicrobial, oxytocic","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45466383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Fortification of foods is often performed to formulate and develop functional foods that improve the nutritional and health status of consumers. Methods: In this study, a spice-blend (cayenne pepper, garlic and ginger) was incorporated into wheat flour at 5, 10, 15 and 20% for the production of nutritional and healthy cookies. Physicochemical, nutritional, sensory, total phenolics, antioxidant activity and alpha-amylase inhibitory assays of the cookies were performed and compared with control cookies and standards (vitamin C and acarbose ) respectively. Results: Significant differences (P<0.05) were observed in core, weight, diameter, height, and texture of the spice-blend cookies. Fat, ash, fibre, magnesium, potassium, sodium, phosphorous and manganese contents of the cookies were significantly improved, especially as the spice mix increased, while iron, calcium copper and zinc were stable. Sensory evaluation revealed a high acceptability of the spice-cookies at up to 5% fortification. Interestingly, although the total phenol and flavonoid content of the fortified cookies was low, the antioxidant activity was high compared to control cookies and competitively with vitamin C, the standard antioxidant used. Inhibitory activity of the fortified cookies against alpha-amylase was significant and dose responsive. Conclusion: These results indicate that the spice blend at 5% addition has potential as a therapeutic healthy snack for the prevention of malnutrition and hyperglycemia in type 2 diabetes.Keywords: cookies, functional foods, hyperglycemia, sensory, bioactive compounds
{"title":"In vitro Alpha-amylase inhibition, antioxidant, nutritional and sensory properties of functional spice-blend fortified cookies","authors":"G. Otunola, A. Afolayan","doi":"10.31989/ffhd.v12i2.845","DOIUrl":"https://doi.org/10.31989/ffhd.v12i2.845","url":null,"abstract":"Introduction: Fortification of foods is often performed to formulate and develop functional foods that improve the nutritional and health status of consumers. Methods: In this study, a spice-blend (cayenne pepper, garlic and ginger) was incorporated into wheat flour at 5, 10, 15 and 20% for the production of nutritional and healthy cookies. Physicochemical, nutritional, sensory, total phenolics, antioxidant activity and alpha-amylase inhibitory assays of the cookies were performed and compared with control cookies and standards (vitamin C and acarbose ) respectively. Results: Significant differences (P<0.05) were observed in core, weight, diameter, height, and texture of the spice-blend cookies. Fat, ash, fibre, magnesium, potassium, sodium, phosphorous and manganese contents of the cookies were significantly improved, especially as the spice mix increased, while iron, calcium copper and zinc were stable. Sensory evaluation revealed a high acceptability of the spice-cookies at up to 5% fortification. Interestingly, although the total phenol and flavonoid content of the fortified cookies was low, the antioxidant activity was high compared to control cookies and competitively with vitamin C, the standard antioxidant used. Inhibitory activity of the fortified cookies against alpha-amylase was significant and dose responsive. Conclusion: These results indicate that the spice blend at 5% addition has potential as a therapeutic healthy snack for the prevention of malnutrition and hyperglycemia in type 2 diabetes.Keywords: cookies, functional foods, hyperglycemia, sensory, bioactive compounds","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43729682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Ketogenic diet (KD) is a beneficial nutritional plan consisting of low carbohydrate, high fat, and moderate protein levels and aids in amelioration of some metabolic disorders. The objective of this study is to develop a ketogenic diet model using cheap and readily available fiber sources. METHODS: Cabbage head and coconut fruits were obtained and processed into fiber and ketogenic diet chow. They were further analyzed using standard methods for proximate, mineral, and heavy metals, phytochemicals, and DPPH radical scavenging assay.RESULTS: Carbohydrate content of the samples were (3.35, 4.00, 3.16 and 2.08%) for cabbage feed, coconut feed, coconut fiber, and cabbage fibers, respectively. This conforms to the maximal 4% carbohydrate required for ketogenic diet daily allowable limit. Other nutrients such as lipids and proteins were in high and moderate amounts respectively. Phytochemicals were also present in varied proportions in the samples. CONCLUSION: The developed cabbage and coconut fiber is an appropriate fiber source for ketogenic diet preparation. They are rich in nutrients based on their mineral content. They may be positioned as a nutraceutical for therapeutic and disease prevention action due to their inherent bioactive chemicals and radical scavenging activity. They may pose negligible toxicity risks as the few detected heavy metals are within permissible limits. KEYWORDS: Fibers, ketogenic diet, cabbage, coconut, chemical analysis, and antioxidant
{"title":"Chemometric analysis of ketogenic diet formulated from low-cost dietary fibers","authors":"O. Kayode, A. A. Kayode, Teniola Oyebode","doi":"10.31989/ffhd.v12i1.857","DOIUrl":"https://doi.org/10.31989/ffhd.v12i1.857","url":null,"abstract":"Background: Ketogenic diet (KD) is a beneficial nutritional plan consisting of low carbohydrate, high fat, and moderate protein levels and aids in amelioration of some metabolic disorders. The objective of this study is to develop a ketogenic diet model using cheap and readily available fiber sources. METHODS: Cabbage head and coconut fruits were obtained and processed into fiber and ketogenic diet chow. They were further analyzed using standard methods for proximate, mineral, and heavy metals, phytochemicals, and DPPH radical scavenging assay.RESULTS: Carbohydrate content of the samples were (3.35, 4.00, 3.16 and 2.08%) for cabbage feed, coconut feed, coconut fiber, and cabbage fibers, respectively. This conforms to the maximal 4% carbohydrate required for ketogenic diet daily allowable limit. Other nutrients such as lipids and proteins were in high and moderate amounts respectively. Phytochemicals were also present in varied proportions in the samples. CONCLUSION: The developed cabbage and coconut fiber is an appropriate fiber source for ketogenic diet preparation. They are rich in nutrients based on their mineral content. They may be positioned as a nutraceutical for therapeutic and disease prevention action due to their inherent bioactive chemicals and radical scavenging activity. They may pose negligible toxicity risks as the few detected heavy metals are within permissible limits. KEYWORDS: Fibers, ketogenic diet, cabbage, coconut, chemical analysis, and antioxidant ","PeriodicalId":12623,"journal":{"name":"Functional Foods in Health and Disease","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46146044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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