These concurrent infections have overlapping clinical manifestations and season of presentation. Dengue and malaria are both endemic in Mumbai and represent a major public health burden in this region & dengue is prevalent throughout India. These infections being vector borne diseases, the reason for simultaneous infection can be the same breeding period of the vectors in post-monsoon season. In this article we have reported a 37 year-old male, resident of Mumbai, hotel waiter by occupation returned to Mumbai after a weeklong trip to Rajasthan in December 2023. The patient started developing fever, chills, myalgias, and headache two days following his return and was admitted to our hospital. On investigation rapid antigen test for dengue & malaria shows positive results, so for malaria both thick & thin peripheral blood smear made on which classic headphone forms & gametocytes of Plasmodium Falciprum seen, also ring form of plasmodium vivax seen. Diagnosis of concurrent infections becomes difcult for a physician leading to delay in institution of appropriate treatment.
{"title":"RARE CONCURRENT INFECTION WITH DENGUE AND MALARIA (PLASMODIUM. FALCIPARUM & PLASMODIUM. VIVAX) IN A ADULT MALE","authors":"Madhukar M Gavit, Roshan Shaikh","doi":"10.36106/gjra/0601176","DOIUrl":"https://doi.org/10.36106/gjra/0601176","url":null,"abstract":"These concurrent infections have overlapping clinical manifestations and season of presentation.\u0000Dengue and malaria are both endemic in Mumbai and represent a major public health burden in this\u0000region & dengue is prevalent throughout India. These infections being vector borne diseases, the reason for simultaneous\u0000infection can be the same breeding period of the vectors in post-monsoon season. In this article we have reported a 37 year-old\u0000male, resident of Mumbai, hotel waiter by occupation returned to Mumbai after a weeklong trip to Rajasthan in December 2023.\u0000The patient started developing fever, chills, myalgias, and headache two days following his return and was admitted to our\u0000hospital. On investigation rapid antigen test for dengue & malaria shows positive results, so for malaria both thick & thin\u0000peripheral blood smear made on which classic headphone forms & gametocytes of Plasmodium Falciprum seen, also ring form\u0000of plasmodium vivax seen. Diagnosis of concurrent infections becomes difcult for a physician leading to delay in institution of\u0000appropriate treatment.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Delirium prevention involves multifaceted strategies, targeting modiable risk factors through nonpharmacologic interventions. Orientation protocols, cognitive stimulation, sleep enhancement, early mobilization, and minimizing physical restraints are key components. Additionally, addressing medication-related risks and prompt management of medical complications are crucial preventive measures. In delirium management, identifying and treating underlying conditions, providing supportive medical care, and managing agitation are essential. Antipsychotic medications, benzodiazepines, and cholinesterase inhibitors have specic roles, with cautious consideration of potential risks. Pain management, especially with nonopioid analgesics, plays a pivotal role. Ethical considerations, including informed consent and respecting patient preferences, are integral to the treatment approach. Delirium outcomes are severe, impacting older individuals with prolonged hospitalizations, functional and cognitive decline, elevated mortality rates, and an increased risk of institutionalization. Mortality associated with delirium remains high even after adjusting for confounding factors, making it an independent marker for post-hospitalization mortality. Persistent cognitive dysfunction, particularly in those with underlying dementia, is a concerning long-term outcome.
{"title":"UNTANGLING THE THREADS OF DELIRIUM: A REVIEW ON ITS MULTIFACETED NATURE AND DIAGNOSTIC COMPLEXITIES","authors":"Luisa Fernanda Montoya Arrieta","doi":"10.36106/gjra/1907898","DOIUrl":"https://doi.org/10.36106/gjra/1907898","url":null,"abstract":"Delirium prevention involves multifaceted strategies, targeting modiable risk factors through\u0000nonpharmacologic interventions. Orientation protocols, cognitive stimulation, sleep enhancement, early\u0000mobilization, and minimizing physical restraints are key components. Additionally, addressing medication-related risks and\u0000prompt management of medical complications are crucial preventive measures. In delirium management, identifying and\u0000treating underlying conditions, providing supportive medical care, and managing agitation are essential. Antipsychotic\u0000medications, benzodiazepines, and cholinesterase inhibitors have specic roles, with cautious consideration of potential risks.\u0000Pain management, especially with nonopioid analgesics, plays a pivotal role. Ethical considerations, including informed\u0000consent and respecting patient preferences, are integral to the treatment approach. Delirium outcomes are severe, impacting\u0000older individuals with prolonged hospitalizations, functional and cognitive decline, elevated mortality rates, and an increased\u0000risk of institutionalization. Mortality associated with delirium remains high even after adjusting for confounding factors, making\u0000it an independent marker for post-hospitalization mortality. Persistent cognitive dysfunction, particularly in those with\u0000underlying dementia, is a concerning long-term outcome.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Palliative care is the science of promoting quality of life of a patient that is typically thought of as the intensive care given to a patient who is on the verge of passing away. Nurses need to acquire specic knowledge and abilities to provide quality palliative care. It is a strategy to enhance the quality of life for patients and their families dealing life-threatening illness by preventing and relieving suffering through early detection, accurate assessment and treatment of pain and physical, psychosocial and spiritual issues. Investigator undertaken this study to assess knowledge and attitude of staff nurses towards Palliative care in Oncology Nursing, using descriptive survey design. 60 staff nurses working in different government hospitals were selected as participants through non probability convenience sampling technique, following selected inclusion and exclusion criteria. Socio-demographic characteristics of participants, their knowledge and attitude towards Palliative care in Oncology Nursing were collected by structured questionnaire, PCQON and FATCOD. Study revealed that among 60 participants, only 30% (18) respondents have good knowledge towards Palliative Care in Oncology Nursing and maximum 77% (46) participants have positive attitude towards the PC in Oncology Nursing. There is no signicant relationship between nurses' knowledge on PC in Oncology Nursing and their clinical experience (χ2=0.76) and type of hospital they are working (χ2=0.09) df =1, p<0.05.Although a few nurses may have good knowledge but majority of them have good attitude towards Palliative care in Oncology Nursing.
{"title":"ASSESSMENT OF KNOWLEDGE AND ATTITUDE TOWARDS PALLIATIVE CARE IN ONCOLOGY NURSING AMONG NURSING PERSONNEL, WEST BENGAL, INDIA.","authors":"Sumana Saha","doi":"10.36106/gjra/5806780","DOIUrl":"https://doi.org/10.36106/gjra/5806780","url":null,"abstract":"Palliative care is the science of promoting quality of life of a patient that is typically thought of as the\u0000intensive care given to a patient who is on the verge of passing away. Nurses need to acquire specic\u0000knowledge and abilities to provide quality palliative care. It is a strategy to enhance the quality of life for patients and their\u0000families dealing life-threatening illness by preventing and relieving suffering through early detection, accurate assessment\u0000and treatment of pain and physical, psychosocial and spiritual issues. Investigator undertaken this study to assess knowledge\u0000and attitude of staff nurses towards Palliative care in Oncology Nursing, using descriptive survey design. 60 staff nurses\u0000working in different government hospitals were selected as participants through non probability convenience sampling\u0000technique, following selected inclusion and exclusion criteria. Socio-demographic characteristics of participants, their\u0000knowledge and attitude towards Palliative care in Oncology Nursing were collected by structured questionnaire, PCQON and\u0000FATCOD. Study revealed that among 60 participants, only 30% (18) respondents have good knowledge towards Palliative Care\u0000in Oncology Nursing and maximum 77% (46) participants have positive attitude towards the PC in Oncology Nursing. There is\u0000no signicant relationship between nurses' knowledge on PC in Oncology Nursing and their clinical experience (χ2=0.76) and\u0000type of hospital they are working (χ2=0.09) df =1, p<0.05.Although a few nurses may have good knowledge but majority of\u0000them have good attitude towards Palliative care in Oncology Nursing.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This Study aimed to assess the efcacy of topical application of Mitomycin C as two doses, intraoperative and 3 weeks later, in the prevention of adhesions formation after functional endoscopic sinus surgery. Materials and Methods: A prospective randomized clinical trial conducted in Otorhinolaryngology Department, Tishreen University Hospital, Lattakia, Syria, between July 2021 and July 2022. The study included 62 patients underwent bilateral functional endoscopic sinus surgery (Fess) for chronic rhinosinusitis with or without polyps. A cotton pledget soaked with 1ml of mitomycin C (0,8 mg/ml) was randomly applied in the middle meatus of one nasal cavity (study side) for 5 minutes and a second pledget soaked with 1ml normal saline was applied in the contralateral side (control side) at the completion of surgery and repeated 3 weeks later. Patients were followed for 3 months after surgery (1st week ,3rd week ,6th month ,3rd months) and assessed endoscopically for any adhesion formation and the side of it. Lund_ Kennedy endoscopic score was recorded and compared between the two sides. Results: Adhesions were observed in 11 patients (17,74%), two patients had bilateral adhesions. 4 adhesions were in the mitomycin C side (6,45%) and 11 in the control side (17,74%) but this difference was not statistically signicant (p value =0.55). According to the endoscopic score there was a statistically signicant difference between the two groups especially after the second application of mitomycin C (p value <0,0001). Conclusion: Topical application of Mitomycin C intra_ and postoperative may reduce the incidence of adhesions after functional endoscopic sinus surgery in the dose used in our study, and improve the mucosal healing.
{"title":"TOPICAL MITOMYCIN C IN PREVENTION OF ADHESIONS FORMATION AFTER FUNCTIONAL ENDOSCOPIC SINUS SURGERY","authors":"Yara Mahmoud Sulieman, Mostafa Ibrahim, Youssef Youssef","doi":"10.36106/gjra/2706665","DOIUrl":"https://doi.org/10.36106/gjra/2706665","url":null,"abstract":"Objective: This Study aimed to assess the efcacy of topical application of Mitomycin C as two doses,\u0000intraoperative and 3 weeks later, in the prevention of adhesions formation after functional endoscopic\u0000sinus surgery. Materials and Methods: A prospective randomized clinical trial conducted in Otorhinolaryngology Department,\u0000Tishreen University Hospital, Lattakia, Syria, between July 2021 and July 2022. The study included 62 patients underwent\u0000bilateral functional endoscopic sinus surgery (Fess) for chronic rhinosinusitis with or without polyps. A cotton pledget soaked\u0000with 1ml of mitomycin C (0,8 mg/ml) was randomly applied in the middle meatus of one nasal cavity (study side) for 5 minutes\u0000and a second pledget soaked with 1ml normal saline was applied in the contralateral side (control side) at the completion of\u0000surgery and repeated 3 weeks later. Patients were followed for 3 months after surgery (1st week ,3rd week ,6th month ,3rd\u0000months) and assessed endoscopically for any adhesion formation and the side of it. Lund_ Kennedy endoscopic score was\u0000recorded and compared between the two sides. Results: Adhesions were observed in 11 patients (17,74%), two patients had\u0000bilateral adhesions. 4 adhesions were in the mitomycin C side (6,45%) and 11 in the control side (17,74%) but this difference\u0000was not statistically signicant (p value =0.55). According to the endoscopic score there was a statistically signicant\u0000difference between the two groups especially after the second application of mitomycin C (p value <0,0001). Conclusion:\u0000Topical application of Mitomycin C intra_ and postoperative may reduce the incidence of adhesions after functional\u0000endoscopic sinus surgery in the dose used in our study, and improve the mucosal healing.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The study on the operational efciency of Kerala State Road Transport Corporation aims to analyse the various costs that affect the protability of the rm. This study also determines the revenue required per year to achieve break even. The type of research used for the study is quantitative research and the main sources of data is secondary. The tools used for the study include ratio analysis and cost analysis. The study found that the possibility of achievement of breakeven situation is also a challenging task for KSRTC. They must come up with radical steps to improve the nancial situation of KSRTC which is severely caused by the current operating procedures.
{"title":"A STUDY ON THE OPERATIONAL EFFICIENCY OF KERALA STATE ROAD TRANSPORT CORPORATION (KSRTC)","authors":"Priya Prasad, B. B","doi":"10.36106/gjra/2608782.","DOIUrl":"https://doi.org/10.36106/gjra/2608782.","url":null,"abstract":"The study on the operational efciency of Kerala State Road Transport Corporation aims to analyse the\u0000various costs that affect the protability of the rm. This study also determines the revenue required per\u0000year to achieve break even. The type of research used for the study is quantitative research and the main sources of data is\u0000secondary. The tools used for the study include ratio analysis and cost analysis. The study found that the possibility of\u0000achievement of breakeven situation is also a challenging task for KSRTC. They must come up with radical steps to improve the\u0000nancial situation of KSRTC which is severely caused by the current operating procedures.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hemalatha E, Jothilakshmi D, Sevvanthi S, K. Balasankari, S. P. Sankar, M. S. Kumar
Odontogenic infections are constantly seen in the dental practice, being dental caries its main etiology; thus, dentists should be familiarized with its donation and operation as it can spread eetly and have serious consequences. The purpose of this article is to give essential knowledge on the pathogenesis – spread, diagnosis, possible complications and treatment of odontogenic infections.
{"title":"OROFACIAL INFECTIONS – ROUTE OF SPREAD – A COMPLETE REVIEW","authors":"Hemalatha E, Jothilakshmi D, Sevvanthi S, K. Balasankari, S. P. Sankar, M. S. Kumar","doi":"10.36106/gjra/7606575","DOIUrl":"https://doi.org/10.36106/gjra/7606575","url":null,"abstract":"Odontogenic infections are constantly seen in the dental practice, being dental caries its main etiology;\u0000thus, dentists should be familiarized with its donation and operation as it can spread eetly and have\u0000serious consequences. The purpose of this article is to give essential knowledge on the pathogenesis – spread, diagnosis,\u0000possible complications and treatment of odontogenic infections.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fetal movements are a sign of fetal well-being and its count is a non-invasive method of screening for the fetus at risk of poor pregnancy outcomes. The wide and multifactorial etiology of decreased fetal movements is a dilemma and data on its association with obstetric factors is conicting. Maternal perception of fetal movements is a self-screening method for assessing fetal well-being and serves as an indirect measure of central nervous system integrity and function. This study aims to assess obstetric factors in women with decreased fetal movement beyond 34 weeks of gestation and its pregnancy outcomes. Summary: There was a higher incidence of poor fetal outcome and stillbirth in cases of high-risk group. Decreased FM being an indicator of fetal compromise, fetuses with non-reassuring CTG were delivered on admission and thus few of them were managed to have had good perinatal outcomes.
{"title":"ASSESSMENT OF OBSTETRIC FACTORS AND PREGNANCY OUTCOMES IN WOMEN WITH DECREASED FETAL MOVEMENT BEYOND 34 WEEKS OF GESTATION","authors":"Anjali Sinha, Shivani Agarwal","doi":"10.36106/gjra/8205834","DOIUrl":"https://doi.org/10.36106/gjra/8205834","url":null,"abstract":"Fetal movements are a sign of fetal well-being and its count is a non-invasive method of screening for the\u0000fetus at risk of poor pregnancy outcomes. The wide and multifactorial etiology of decreased fetal\u0000movements is a dilemma and data on its association with obstetric factors is conicting. Maternal perception of fetal movements\u0000is a self-screening method for assessing fetal well-being and serves as an indirect measure of central nervous system integrity\u0000and function. This study aims to assess obstetric factors in women with decreased fetal movement beyond 34 weeks of gestation\u0000and its pregnancy outcomes. Summary: There was a higher incidence of poor fetal outcome and stillbirth in cases of high-risk\u0000group. Decreased FM being an indicator of fetal compromise, fetuses with non-reassuring CTG were delivered on admission\u0000and thus few of them were managed to have had good perinatal outcomes.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Halley Antony, Faisal Mohiuddin Mulla, Sahil Gupta, Deepak Cd
Background- The management of distal tibia fractures is still a subject of debate for orthopaedic surgeons in terms of both, reduction and xation. The subcutaneous location and soft tissue anatomy of the tibia predispose it to angular and rotational instability. The disadvantage of traditional plating techniques is that it requires large exposure to approach distal tibia, a bone characterized by limited soft tissue coverage and poor vascularity. Minimally invasive plating offers many advantages over conventional open techniques. It causes minimal soft tissue dissection and surgical trauma to the bone. Minimally invasive plate osteosynthesis (MIPO) maintains the biological conguration of the distal tibia and fracture hematoma and also provides a biomechanically stable construct, enabling biological healing. Purpose: To study the functional and radiological outcome of patients with distal thirds diaphyseal-metaphyseal tibial fractures treated by minimally invasive plate osteosynthesis and to document major and minor complications associated with this treatment modality. Materials and Methods: A prospective observational study of cases of distal third diaphyseometaphyseal tibial fractures meeting the inclusion criteria who were admitted in Adichunchanagiri institute of medical sciences, Department of Orthopaedics, BG nagara between 01-02- 2021 to 01-07-2022 was carried out. Fractures were classied according to AO classication [1] and minimally invasive plate osteosynthesis was done. After a minimum follow up period of 6 months the functional and radiological outcomes were assessed using Olerud -Molander Ankle scoring system [2] and anterord posterior and lateral radiographs on follow up. Results: A series of 50 cases with distal 1/3 tibia fractures were studied comprising of 30 males and 20 females. The largest contribution came from the age group of 31-40 and 41-50 years (50%). Road trafc accidents was the commonest cause of injury (60%). Most common fracture pattern was AO Type 43 A2. Associated bula rd fracture was present in 24 patients of which 15 patients underwent xation with ORIF with 1/3 tubular plate or CRIF with Rush pin. Majority of patients, time interval between injury and surgery was less than 5 days (36 patients). A total of 5 cases were found to develop complications including supercial (3 cases) and deep infection (2 case). The time to union was between 16-28 weeks. Average time to union was 24 weeks. Olerud and Molander score was used for functional evaluation, post xation. At the end of 6 months excellent functional outcome was achieved in 27 cases, good results in 21 cases and fair result in 2 cases. Conclusion: This single center, medium size population series demonstrated good to excellent results in a majority of the patients after distal tibia fracture xation using minimally invasive plate osteosynthesis, with outcomes and complications comparable to other studies in literature. Our study shows that plating with MI
{"title":"SURGICAL MANAGEMENT OF DISTAL THIRD TIBIA FRACTURE BY MINIMALLY INVASIVE PLATE OSTEOSYNTHESIS","authors":"Halley Antony, Faisal Mohiuddin Mulla, Sahil Gupta, Deepak Cd","doi":"10.36106/gjra/6106320","DOIUrl":"https://doi.org/10.36106/gjra/6106320","url":null,"abstract":"Background- The management of distal tibia fractures is still a subject of debate for orthopaedic\u0000surgeons in terms of both, reduction and xation. The subcutaneous location and soft tissue anatomy of\u0000the tibia predispose it to angular and rotational instability. The disadvantage of traditional plating techniques is that it requires\u0000large exposure to approach distal tibia, a bone characterized by limited soft tissue coverage and poor vascularity. Minimally\u0000invasive plating offers many advantages over conventional open techniques. It causes minimal soft tissue dissection and\u0000surgical trauma to the bone. Minimally invasive plate osteosynthesis (MIPO) maintains the biological conguration of the\u0000distal tibia and fracture hematoma and also provides a biomechanically stable construct, enabling biological healing.\u0000Purpose: To study the functional and radiological outcome of patients with distal thirds diaphyseal-metaphyseal tibial\u0000fractures treated by minimally invasive plate osteosynthesis and to document major and minor complications associated with\u0000this treatment modality. Materials and Methods: A prospective observational study of cases of distal third diaphyseometaphyseal tibial fractures meeting the inclusion criteria who were admitted in Adichunchanagiri institute of medical\u0000sciences, Department of Orthopaedics, BG nagara between 01-02- 2021 to 01-07-2022 was carried out. Fractures were classied\u0000according to AO classication [1] and minimally invasive plate osteosynthesis was done. After a minimum follow up period of 6\u0000months the functional and radiological outcomes were assessed using Olerud -Molander Ankle scoring system [2] and anterord posterior and lateral radiographs on follow up. Results: A series of 50 cases with distal 1/3 tibia fractures were studied\u0000comprising of 30 males and 20 females. The largest contribution came from the age group of 31-40 and 41-50 years (50%). Road\u0000trafc accidents was the commonest cause of injury (60%). Most common fracture pattern was AO Type 43 A2. Associated bula\u0000rd fracture was present in 24 patients of which 15 patients underwent xation with ORIF with 1/3 tubular plate or CRIF with Rush\u0000pin. Majority of patients, time interval between injury and surgery was less than 5 days (36 patients). A total of 5 cases were\u0000found to develop complications including supercial (3 cases) and deep infection (2 case). The time to union was between 16-28\u0000weeks. Average time to union was 24 weeks. Olerud and Molander score was used for functional evaluation, post xation. At the\u0000end of 6 months excellent functional outcome was achieved in 27 cases, good results in 21 cases and fair result in 2 cases.\u0000Conclusion: This single center, medium size population series demonstrated good to excellent results in a majority of the\u0000patients after distal tibia fracture xation using minimally invasive plate osteosynthesis, with outcomes and complications\u0000comparable to other studies in literature. Our study shows that plating with MI","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Plasmapheresis is therapeutic procedure that involves extracorporeal removal, return or exchange of blood or plasma products. It is an intensive care procedure that requires appropriate decision, specialized skill based training, close monitoring, and follow-up for best clinical outcomes. Aims And Objective: Identify clinical proles of patient and their relation to clinical output with plasmapheresis, Review the potential complications and clinical signicance of plasmapheresis. Material And Methods: Indoor Patients of various neurological, autoimmune diseases in Tertiary government hospital, which full the criteria for study. Result And Observations: It was observed during study that GBS-AIDP( acute inammatory demyelinating polyneuropathy) was the most common disease in patient undergoing plasmapheresis. Metabolic syndrome (obesity/diabetes/hypertension) were among the highest associated comorbidities. However, no statistically signicant association was seen between age, sex, occupation, comorbidity such as hypertension, obesity and hypothyroidism in present study. (p>0.05). Discussion: It was observed during study that out of 30 patient who underwent plasmapheresis, Positive correlation was found in AIDP incidence and Hba1c level >5.6%. Poor prognosis was found in patients with baseline CRP level >30mg% compared to those with <30mg. However, larger trials with bigger sample size should be carried out to conrm this nding from our study
{"title":"STUDY OF CLINICAL PROFILE OF ADULT PATIENTS UNDERGOING PLASMAPHERESIS AT TERTIARY CARE CENTER","authors":"Darpan Kothia, Upasna Dhuliya, Pallav Desai, Ronak Javia, Mansi Gupta, Raja Joshi, Manish Mehta","doi":"10.36106/gjra/2106273","DOIUrl":"https://doi.org/10.36106/gjra/2106273","url":null,"abstract":"Introduction: Plasmapheresis is therapeutic procedure that involves extracorporeal removal, return or\u0000exchange of blood or plasma products. It is an intensive care procedure that requires appropriate\u0000decision, specialized skill based training, close monitoring, and follow-up for best clinical outcomes. Aims And Objective:\u0000Identify clinical proles of patient and their relation to clinical output with plasmapheresis, Review the potential complications\u0000and clinical signicance of plasmapheresis. Material And Methods: Indoor Patients of various neurological, autoimmune\u0000diseases in Tertiary government hospital, which full the criteria for study. Result And Observations: It was observed during\u0000study that GBS-AIDP( acute inammatory demyelinating polyneuropathy) was the most common disease in patient undergoing\u0000plasmapheresis. Metabolic syndrome (obesity/diabetes/hypertension) were among the highest associated comorbidities.\u0000However, no statistically signicant association was seen between age, sex, occupation, comorbidity such as hypertension,\u0000obesity and hypothyroidism in present study. (p>0.05). Discussion: It was observed during study that out of 30 patient who\u0000underwent plasmapheresis, Positive correlation was found in AIDP incidence and Hba1c level >5.6%. Poor prognosis was\u0000found in patients with baseline CRP level >30mg% compared to those with <30mg. However, larger trials with bigger sample\u0000size should be carried out to conrm this nding from our study","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140506574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Frequent exacerbations raise the risk of persistent asthma in adults and contribute to high treatment costs. Thus, the main goals of asthma management, are to reduce the rate of exacerbations, to achieve asthma control and from an economic perspective to reduce the burden of this disease through maximizing health gain with available resources. This study compares the costs and effectiveness of dual and triple therapy to achieve a better asthma control and good quality of life (QOL) at a lower cost. A prospective observational comparative stu Methods: dy conducted at a hospital on 80 asthma patients, out of which 40 received dual and the other 40 received triple therapy. All subjects completed the Mini Asthma Quality of Life Questionnaire (MAQLQ) and Asthma Control Test (ACT) at baseline and after 2 and 4 weeks, respectively, of follow- up visits. The mean of post FEV1 and PEFR between dual therapy (69.0 Results: 25±15.7 and 61.95±13.6 respectively) and triple therapy (73.925±11.5 and 69.725±9.2) showed signicant improvement in lung function with triple therapy. At week 4, in dual therapy and triple therapy mean change from baseline in total ACT Score was 3.55±0.006 (P<0.05) to 4.675±0.49 (P <0.05) respectively and at week 2, in dual therapy and triple therapy mean change from baseline in MAQLQ score was 0.237±-0.03 (P<0.05) to 0.255±-0.005 (P<0.05) respectively. Triple therapy is more cost-effective than Conclusion: dual therapy to treat adults with moderate to severe asthma who are symptomatic despite current doses. In addition, it can improve QOL and better control of asthma.
{"title":"“COST EFFECTIVENESS COMPARISON OF LONG-ACTING MUSCARINIC ANTAGONISTS (LAMA) ADDED TO COMBINATION LONG-ACTING BETAAGONISTS AND INHALED CORTICOSTEROIDS (LABA/ICS) [TRIPLETHERAPY] V/S LABA/ICS [DUAL THERAPY] IN MODERATE TO SEVERE ASTHMA”","authors":"Masarrath Unnisa, Ifra Umme Aiman, Hafsa Fatima","doi":"10.36106/gjra/0307025","DOIUrl":"https://doi.org/10.36106/gjra/0307025","url":null,"abstract":"Background: Frequent exacerbations raise the risk of persistent asthma in adults and contribute to high\u0000treatment costs. Thus, the main goals of asthma management, are to reduce the rate of exacerbations, to\u0000achieve asthma control and from an economic perspective to reduce the burden of this disease through maximizing health gain\u0000with available resources. This study compares the costs and effectiveness of dual and triple therapy to achieve a better asthma\u0000control and good quality of life (QOL) at a lower cost. A prospective observational comparative stu Methods: dy conducted at a\u0000hospital on 80 asthma patients, out of which 40 received dual and the other 40 received triple therapy. All subjects completed the\u0000Mini Asthma Quality of Life Questionnaire (MAQLQ) and Asthma Control Test (ACT) at baseline and after 2 and 4 weeks,\u0000respectively, of follow- up visits. The mean of post FEV1 and PEFR between dual therapy (69.0 Results: 25±15.7 and 61.95±13.6\u0000respectively) and triple therapy (73.925±11.5 and 69.725±9.2) showed signicant improvement in lung function with triple\u0000therapy. At week 4, in dual therapy and triple therapy mean change from baseline in total ACT Score was 3.55±0.006 (P<0.05)\u0000to 4.675±0.49 (P <0.05) respectively and at week 2, in dual therapy and triple therapy mean change from baseline in MAQLQ\u0000score was 0.237±-0.03 (P<0.05) to 0.255±-0.005 (P<0.05) respectively. Triple therapy is more cost-effective than Conclusion:\u0000dual therapy to treat adults with moderate to severe asthma who are symptomatic despite current doses. In addition, it can\u0000improve QOL and better control of asthma.","PeriodicalId":12664,"journal":{"name":"Global journal for research analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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