{"title":"Artery of percheron stroke: a case report","authors":"Marcelo Zalli, Victor Cubas Schulz, Henrique Orefice Farah, Matheus Soares Flor","doi":"10.15406/mojbm.2021.06.00132","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00132","url":null,"abstract":"","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116695172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/MOJBM.2019.04.00115
Shuangsheng Yan, Rasheed Abdulwase, A. Abbas
Most peoples have used Ginger as traditional medicine or spices for food during thousands of years ago. Ginger is an important component of traditional medicine used widely as an alternative or free medicines in most parts of the world. Previous studies review the influence and important of Ginger as a commercial product in China, so we found that Ginger has a magical therapeutics to inhibit the diseases, moreover it will become source of incomes if it is marketed in a good way.
{"title":"Ginger as a commercial product in China","authors":"Shuangsheng Yan, Rasheed Abdulwase, A. Abbas","doi":"10.15406/MOJBM.2019.04.00115","DOIUrl":"https://doi.org/10.15406/MOJBM.2019.04.00115","url":null,"abstract":"Most peoples have used Ginger as traditional medicine or spices for food during thousands of years ago. Ginger is an important component of traditional medicine used widely as an alternative or free medicines in most parts of the world. Previous studies review the influence and important of Ginger as a commercial product in China, so we found that Ginger has a magical therapeutics to inhibit the diseases, moreover it will become source of incomes if it is marketed in a good way.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125669671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/mojbm.2021.06.00138
Sanzida Islam Bristi
Together with the use of number of repurposed/ repositioned antiviral drugs and immunomodulatory agents against the severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, currently several vaccines are under human trials to mitigate the COVID-19 worldwide. Although the drugs and vaccines appear to be effective in maximum cases or trials; however, the associated side effects, the required induction of the long-lasting immunity, and finally, the safety concerns are of significance in terms of their consistent application/ administration. A vast research on the SARS-CoV-2 genomics and on its similarities with SARS-CoV-1 and with the Middle East Respiratory Syndrome coronavirus (MERS-CoV) have unraveled the viral avoidance of the host immunity which creates a challenge in course of effective vaccine development although several COVID-19 vaccines are currently being used commercially worldwide. Such an unsteady circumstance led the scientists also to think on a new remedial approach i.e., the RNA interference (RNAi) therapy to inhibit the SARS-CoV-2 proliferation by degrading the viral RNAs. Present review discussed such strategy and its effectiveness during the ongoing COVID-19 pandemic.
{"title":"A brief note on the scope of RNA interference(RNAi) therapy in mitigating COVID-19","authors":"Sanzida Islam Bristi","doi":"10.15406/mojbm.2021.06.00138","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00138","url":null,"abstract":"Together with the use of number of repurposed/ repositioned antiviral drugs and immunomodulatory agents against the severe acute respiratory coronavirus 2 (SARS-CoV-2) infection, currently several vaccines are under human trials to mitigate the COVID-19 worldwide. Although the drugs and vaccines appear to be effective in maximum cases or trials; however, the associated side effects, the required induction of the long-lasting immunity, and finally, the safety concerns are of significance in terms of their consistent application/ administration. A vast research on the SARS-CoV-2 genomics and on its similarities with SARS-CoV-1 and with the Middle East Respiratory Syndrome coronavirus (MERS-CoV) have unraveled the viral avoidance of the host immunity which creates a challenge in course of effective vaccine development although several COVID-19 vaccines are currently being used commercially worldwide. Such an unsteady circumstance led the scientists also to think on a new remedial approach i.e., the RNA interference (RNAi) therapy to inhibit the SARS-CoV-2 proliferation by degrading the viral RNAs. Present review discussed such strategy and its effectiveness during the ongoing COVID-19 pandemic.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132880200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/mojbm.2021.06.00139
Juan Farak Gomez
Context: The incidence of autoimmune diseases and allergies has increased markedly in the last half of the 20th century, especially in more developed countries, with an increase in urbanization and hygiene that has led to the elimination of many parasitic infections. Objective: To analyze through scientific bibliographic sources the effects of the parasite load, especially helminthiasis, on the appearance of autoimmune and allergic diseases. Methodology: The documentary analysis of different scientific sources that refer to the theory of immunomodulation by helminths was used. Results: They suggest that the treatment of autoimmune diseases with helminths or products derived from them can have protective and therapeutic effects in these patients. Conclusions: It could be concluded that the immunodulation mechanisms carried out by helminths prevent patients from eliminating the parasites, but have beneficial effects on the course of some autoimmune diseases. Although the causal relationship is not fully proven, studies in animal models and clinical trials carried out in patients with autoimmune diseases suggest that their treatment with helminths or products derived from them may have protective and therapeutic effects in these patients.
{"title":"Immunomodulation by helmintos: Possible use as therapy for autoimmune diseases","authors":"Juan Farak Gomez","doi":"10.15406/mojbm.2021.06.00139","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00139","url":null,"abstract":"Context: The incidence of autoimmune diseases and allergies has increased markedly in the last half of the 20th century, especially in more developed countries, with an increase in urbanization and hygiene that has led to the elimination of many parasitic infections. Objective: To analyze through scientific bibliographic sources the effects of the parasite load, especially helminthiasis, on the appearance of autoimmune and allergic diseases. Methodology: The documentary analysis of different scientific sources that refer to the theory of immunomodulation by helminths was used. Results: They suggest that the treatment of autoimmune diseases with helminths or products derived from them can have protective and therapeutic effects in these patients. Conclusions: It could be concluded that the immunodulation mechanisms carried out by helminths prevent patients from eliminating the parasites, but have beneficial effects on the course of some autoimmune diseases. Although the causal relationship is not fully proven, studies in animal models and clinical trials carried out in patients with autoimmune diseases suggest that their treatment with helminths or products derived from them may have protective and therapeutic effects in these patients.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131601663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/mojbm.2021.06.00148
Melancholy is major mental challenges that is characterize by sadness, sleep disorder, decrease energy, etc. It also have a great social and mental consequences, it is well know that depression will be the second largest cause of disability globally till 2020. The risk are even higher in developed countries. According to world health organization globally it effect more than 121 million people. Depression is a complex and multi-dimensional anarchy according to it has many faces and cannot be describing by one simple formula because it originate from numerous complex mechanism. Multi-faced nature of depression makes it difficult to find out its etiology. The purpose of this study is to find out the prevalence of melancholy in different age groups and genders in district Swat. Overall 300 samples were collected randomly across different age groups and genders in which we found the prevalence of melancholy were 48.3% in which male depressed individual were 27.6% while female depressed were 20.6%. The number of depressed individual were maximum in age group vary from 10-20 which is 15%. To conclude depression is easily manageable but it need understanding that how to control your feeling and thought and think new and positively.
{"title":"Prevalence of melancholy in swat valley, Pakistan","authors":"","doi":"10.15406/mojbm.2021.06.00148","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00148","url":null,"abstract":"Melancholy is major mental challenges that is characterize by sadness, sleep disorder, decrease energy, etc. It also have a great social and mental consequences, it is well know that depression will be the second largest cause of disability globally till 2020. The risk are even higher in developed countries. According to world health organization globally it effect more than 121 million people. Depression is a complex and multi-dimensional anarchy according to it has many faces and cannot be describing by one simple formula because it originate from numerous complex mechanism. Multi-faced nature of depression makes it difficult to find out its etiology. The purpose of this study is to find out the prevalence of melancholy in different age groups and genders in district Swat. Overall 300 samples were collected randomly across different age groups and genders in which we found the prevalence of melancholy were 48.3% in which male depressed individual were 27.6% while female depressed were 20.6%. The number of depressed individual were maximum in age group vary from 10-20 which is 15%. To conclude depression is easily manageable but it need understanding that how to control your feeling and thought and think new and positively.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124696237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/MOJBM.2021.06.00126
Sunita Singh
Herbs and spices are the very best way to add flavor and dimension to a dish without adding fat, salt or calories. In fact, some herbs and spices already include a little something extra, like antioxidants. Antioxidants are substances that slow or prevent the oxidative process in which cells are damaged by free radicals, which can lead to cell dysfunction. These powerful nutrients have been linked to the prevention of heart disease and diabetes, improving immune function and lowering the risk of infection and even some cancers. The bioactive compounds present in spices having antioxidant properties mainly consists of flavonoids, phenolic compounds, sulfur-containing compounds, tannins, alkaloids, phenolic diterpenes, and vitamins. While we hear a lot about the antioxidants found in dark chocolate and red wine, spices like ground cloves, oregano leaves, ginger, cinnamon, turmeric and yellow mustard seed are the real antioxidant stars – delivering a higher concentration of antioxidants per 100g than dark chocolate, wine, even blueberries and whole grain cereal. Plus, they have none of the calories found in chocolate or the drawbacks associated with alcohol consumption.
{"title":"Antioxidants properties of some spices with their chemistry and mechanism of action","authors":"Sunita Singh","doi":"10.15406/MOJBM.2021.06.00126","DOIUrl":"https://doi.org/10.15406/MOJBM.2021.06.00126","url":null,"abstract":"Herbs and spices are the very best way to add flavor and dimension to a dish without adding fat, salt or calories. In fact, some herbs and spices already include a little something extra, like antioxidants. Antioxidants are substances that slow or prevent the oxidative process in which cells are damaged by free radicals, which can lead to cell dysfunction. These powerful nutrients have been linked to the prevention of heart disease and diabetes, improving immune function and lowering the risk of infection and even some cancers. The bioactive compounds present in spices having antioxidant properties mainly consists of flavonoids, phenolic compounds, sulfur-containing compounds, tannins, alkaloids, phenolic diterpenes, and vitamins. While we hear a lot about the antioxidants found in dark chocolate and red wine, spices like ground cloves, oregano leaves, ginger, cinnamon, turmeric and yellow mustard seed are the real antioxidant stars – delivering a higher concentration of antioxidants per 100g than dark chocolate, wine, even blueberries and whole grain cereal. Plus, they have none of the calories found in chocolate or the drawbacks associated with alcohol consumption.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124441182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/mojbm.2019.04.00111
Pooja Sharma, Sahil Gupta, N. Bhatt, Shajaat Hussain Ahanger, D. Gupta, P. Singh, R. Lochan, M. Bhagat
The present study aims to explore the chemical constituents and antioxidant potential of Pinus wallichiana essential oil and extracts. Chemical composition of the essential oil was analyzed by GC-MS and result showed that the oil contain three major monoterpene compounds viz. α-pinene (48.6%), β-pinene (45.6%) and limonene (5.6%). Antioxidant potential of Pinus wallichiana was analyzed by three basic methods; DPPH radical scavenging method, FRAP assay and Fe2+ ion chelating activity. Among leaf and bark extracts, best radical scavenging, activity was determined by aqueous extract (IC50 values 20.83±0.8µg/ml) of bark followed by its methanol extract (IC50 value 25.9±1.6µg/ml). The aqueous extract of bark also exhibited better reducing and chelating activity than leaf extracts. Essential oil showed moderate radical scavenging and chelating activity but negligible reducing activity. Phytochemical analysis of extracts determined that the aqueous and methanol extracts of bark contain rich amount of poly phenol and flavonoids, in comparison to the leaf extracts. A significant correlation between the antioxidant activity and these phytoconstituents of the extracts has been observed. The results of the present study concluded that the bark of Pinus wallichiana is a potential source of active antioxidant constituents that could be further explored and exploited for numerous commercial applications.
{"title":"Antioxidant and phytochemical analysis of volatile oil and extracts of Pinus wallichiana","authors":"Pooja Sharma, Sahil Gupta, N. Bhatt, Shajaat Hussain Ahanger, D. Gupta, P. Singh, R. Lochan, M. Bhagat","doi":"10.15406/mojbm.2019.04.00111","DOIUrl":"https://doi.org/10.15406/mojbm.2019.04.00111","url":null,"abstract":"The present study aims to explore the chemical constituents and antioxidant potential of Pinus wallichiana essential oil and extracts. Chemical composition of the essential oil was analyzed by GC-MS and result showed that the oil contain three major monoterpene compounds viz. α-pinene (48.6%), β-pinene (45.6%) and limonene (5.6%). Antioxidant potential of Pinus wallichiana was analyzed by three basic methods; DPPH radical scavenging method, FRAP assay and Fe2+ ion chelating activity. Among leaf and bark extracts, best radical scavenging, activity was determined by aqueous extract (IC50 values 20.83±0.8µg/ml) of bark followed by its methanol extract (IC50 value 25.9±1.6µg/ml). The aqueous extract of bark also exhibited better reducing and chelating activity than leaf extracts. Essential oil showed moderate radical scavenging and chelating activity but negligible reducing activity. Phytochemical analysis of extracts determined that the aqueous and methanol extracts of bark contain rich amount of poly phenol and flavonoids, in comparison to the leaf extracts. A significant correlation between the antioxidant activity and these phytoconstituents of the extracts has been observed. The results of the present study concluded that the bark of Pinus wallichiana is a potential source of active antioxidant constituents that could be further explored and exploited for numerous commercial applications.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122254404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/mojbm.2019.04.00108
Rubia Caldas Umburanas, Priscila Costa Estabile, Rogério Pincela Mateus, Mara Cristina de Almeida, Roberto Ferreira Artoni
Systemic arterial hypertension (SAH) is a multifactorial clinical condition characterized by high and sustained levels of blood pressure (BP). Some studies have reported that variants of the angiotensin-converting enzyme (ace) gene increase the risk of hypertension. The aim of this study was to verify the existence of the relationship between the insertion/deletion (I/D) polymorphism in the ACE gene and its genotypic variants with BP in four distinct groups of hypertensive individuals and also to genetically and epidemiologically characterize the investigated samples. The study was formed of 112 individuals arranged into the following groups: normotensive (control); hypertensive and non-obese; hypertensive and obese; and, hypertensive and with type 2 diabetes mellitus (T2DM). Epidemiological data and peripheral blood were collected from participants for DNA extraction and amplification by PCR (polymerase chain reaction). The allele (D=0.5446; I=0.4554) and genotype (DD =0.2411, ID =0.6071; II =0.1518) frequencies showed low genetic differentiation (Fst<0.05) and were outside the Hardy-Weinberg equilibrium (p<0.05). There was no significant difference between the groups (chi-square=4.4335; p=0.6174). There was no association of the D allele with SAH, reinforcing the hypothesis that environmental interferences are prevalent in the evolution of SAH.
系统性动脉高血压（SAH）是一种多因素临床症状，其特点是血压（BP）水平高且持续。一些研究报告称，血管紧张素转换酶（ace）基因的变异会增加高血压的风险。本研究旨在验证四组不同的高血压患者中，血管紧张素转换酶基因的插入/缺失（I/D）多态性及其基因型变异与血压之间是否存在关系，并从遗传学和流行病学角度分析所调查样本的特征。这项研究将 112 人分为以下几组：血压正常（对照组）；高血压和非肥胖；高血压和肥胖；高血压和 2 型糖尿病（T2DM）。收集参与者的流行病学数据和外周血，以提取 DNA 并通过聚合酶链反应（PCR）进行扩增。等位基因（D=0.5446；I=0.4554）和基因型（DD=0.2411，ID=0.6071；II=0.1518）频率显示出较低的遗传分化（Fst<0.05），并且超出了哈代-温伯格平衡（P<0.05）。组间无明显差异（秩方=4.4335；P=0.6174）。D等位基因与SAH没有关联，这加强了SAH进化过程中普遍存在环境干扰的假设。
{"title":"ACE Gene I/D polymorphism and systemic arterial hypertension in different classes of hypertensive individuals","authors":"Rubia Caldas Umburanas, Priscila Costa Estabile, Rogério Pincela Mateus, Mara Cristina de Almeida, Roberto Ferreira Artoni","doi":"10.15406/mojbm.2019.04.00108","DOIUrl":"https://doi.org/10.15406/mojbm.2019.04.00108","url":null,"abstract":"Systemic arterial hypertension (SAH) is a multifactorial clinical condition characterized by high and sustained levels of blood pressure (BP). Some studies have reported that variants of the angiotensin-converting enzyme (ace) gene increase the risk of hypertension. The aim of this study was to verify the existence of the relationship between the insertion/deletion (I/D) polymorphism in the ACE gene and its genotypic variants with BP in four distinct groups of hypertensive individuals and also to genetically and epidemiologically characterize the investigated samples. The study was formed of 112 individuals arranged into the following groups: normotensive (control); hypertensive and non-obese; hypertensive and obese; and, hypertensive and with type 2 diabetes mellitus (T2DM). Epidemiological data and peripheral blood were collected from participants for DNA extraction and amplification by PCR (polymerase chain reaction). The allele (D=0.5446; I=0.4554) and genotype (DD =0.2411, ID =0.6071; II =0.1518) frequencies showed low genetic differentiation (Fst<0.05) and were outside the Hardy-Weinberg equilibrium (p<0.05). There was no significant difference between the groups (chi-square=4.4335; p=0.6174). There was no association of the D allele with SAH, reinforcing the hypothesis that environmental interferences are prevalent in the evolution of SAH.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127923498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/mojbm.2021.05.00119
J. M. Pereira de Godoy, Francisco de Assis Cury, Maria de Fatima Guerreiro Godoy OT, Fatima Guerreiro Godoy OT
Background: In more than half of cases of chest trauma, patients also have head injuries, abdominal injuries or polytrauma. Aim: The aim of the present study was to compare open and closed treatment for chest injuries according to mortality, hospitalization, trauma indices and physiological data. Method: Three hundred sixty-seven patients (293 males and 74 females) with an Anatomic Injury Scale (AIS) score of 2 or more for thoracic trauma were evaluated. The following aspects were evaluated associations between treatment (open and closed) for chest injury, discharge from hospital, hospitalization and death, Trauma indices Revised Trauma Score (RTS), Injury Severity Score (ISS) and TRISS, Blood pressure, diastolic pressure, respiratory rate and pulse. Results: No significant associations were found between the type of treatment (open or closed procedure) and discharge from hospital, hospitalization or death (p = 0.3).No significant associations were found between the type of treatment (open or closed procedure) and the trauma indices, blood pressure, pulse or respiratory rate.
{"title":"Open and closed treatment of chest injuries: mortality, hospitalization, trauma indices and physiological data","authors":"J. M. Pereira de Godoy, Francisco de Assis Cury, Maria de Fatima Guerreiro Godoy OT, Fatima Guerreiro Godoy OT","doi":"10.15406/mojbm.2021.05.00119","DOIUrl":"https://doi.org/10.15406/mojbm.2021.05.00119","url":null,"abstract":"Background: In more than half of cases of chest trauma, patients also have head injuries, abdominal injuries or polytrauma. Aim: The aim of the present study was to compare open and closed treatment for chest injuries according to mortality, hospitalization, trauma indices and physiological data. Method: Three hundred sixty-seven patients (293 males and 74 females) with an Anatomic Injury Scale (AIS) score of 2 or more for thoracic trauma were evaluated. The following aspects were evaluated associations between treatment (open and closed) for chest injury, discharge from hospital, hospitalization and death, Trauma indices Revised Trauma Score (RTS), Injury Severity Score (ISS) and TRISS, Blood pressure, diastolic pressure, respiratory rate and pulse. Results: No significant associations were found between the type of treatment (open or closed procedure) and discharge from hospital, hospitalization or death (p = 0.3).No significant associations were found between the type of treatment (open or closed procedure) and the trauma indices, blood pressure, pulse or respiratory rate.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116632239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.15406/mojbm.2021.06.00151
Dr Chrysanthus Chukwuma Sr
Cardiovascular disease manifests as an intricately complex entity presenting as a derangement of the cardiovascular system. Cardiac or heart failure connotes the pathophysiological state in which deficient cardiac output compromises the body burden and requirements. Protein kinases regulate several pathophysiological processes and are emerging targets for drug lead or discovery. The protein kinases are family members of the serine/threonine phosphatases. Protein kinases and phosphatases are pivotal in the regulatory mechanisms in the reversible phosphorylation of diverse effectors whereby discrete signaling molecules regulate cardiac excitation and contraction. Protein phosphorylation is critical for the sustenance of cardiac functionalities. The two major contributory ingredients to progressive myocardium derangement are dysregulation of Ca2+processes and contemporaneous elevated concentrations of reactive oxygen species, ROS. Certain cardiac abnormalities include cardiac myopathy or hypertrophy due to response in untoward haemodynamic demand with concomitant progressive heart failure. The homeostasis or equilibrium between protein kinases and phosphatases influence cardiac morphology and excitability during pathological and physiological processes of the cardiovascular system.
{"title":"Exploring the complex interplay in the regulation of cardiac pathophysiological functions by protein kinases and phosphatases","authors":"Dr Chrysanthus Chukwuma Sr","doi":"10.15406/mojbm.2021.06.00151","DOIUrl":"https://doi.org/10.15406/mojbm.2021.06.00151","url":null,"abstract":"Cardiovascular disease manifests as an intricately complex entity presenting as a derangement of the cardiovascular system. Cardiac or heart failure connotes the pathophysiological state in which deficient cardiac output compromises the body burden and requirements. Protein kinases regulate several pathophysiological processes and are emerging targets for drug lead or discovery. The protein kinases are family members of the serine/threonine phosphatases. Protein kinases and phosphatases are pivotal in the regulatory mechanisms in the reversible phosphorylation of diverse effectors whereby discrete signaling molecules regulate cardiac excitation and contraction. Protein phosphorylation is critical for the sustenance of cardiac functionalities. The two major contributory ingredients to progressive myocardium derangement are dysregulation of Ca2+processes and contemporaneous elevated concentrations of reactive oxygen species, ROS. Certain cardiac abnormalities include cardiac myopathy or hypertrophy due to response in untoward haemodynamic demand with concomitant progressive heart failure. The homeostasis or equilibrium between protein kinases and phosphatases influence cardiac morphology and excitability during pathological and physiological processes of the cardiovascular system.","PeriodicalId":127077,"journal":{"name":"MOJ Biology and Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132196331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：