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Vestibular Evoked Myogenic Potentials of Asymptomatic Covid-19 PCR-Positive Cases 无症状Covid-19 pcr阳性病例的前庭诱发肌源性电位
Pub Date : 2020-07-01 DOI: 10.19080/gjo.2020.22.556097
Mustafa Mwm
Background: World Health Organization (WHO) officially announced the COVID-19 epidemic as a pandemic. Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. Little direct evidence suggests a viral cause for labyrinthitis; however, a wealth of epidemiologic evidence implicates several viruses as potentially causing inflammation of the labyrinth. Viral labyrinthitis is often preceded by an upper respiratory tract infection and occurs in epidemics. Aims/Objectives: This study compared latencies of vestibular evoked myogenic potentials (VEMPs) between asymptomatic COVID-19 PCR-positive cases and normal non-infected subjects. Material & methods: Twenty cases who were confirmed positive for COVID-19 and had none of the known symptoms for this viral infection formed the test group for 2 full weeks. Their age ranged between 20-50 years to avoid any age-related hearing affection. Patients who had definite symptoms of COVID-19 infection as well as those who had a history of hearing loss or a history of any known cause of hearing loss were excluded from the examined sample. VEMPs latencies were measured for all participants. Results: Deterioration of saccular hair cell functions was detected by the significantly increased latency of the VEMPs compared to controls. Conclusions and significance: COVID-19 infection could have drastic effects on vestibular hair cell functions despite being asymptomatic. COVID-19 patients should be followed up to detect any complaints regarding their vestibular performance. The mechanism of these effects requires further research.
背景:世界卫生组织(WHO)正式宣布新冠肺炎疫情为大流行。冠状病毒病(COVID-19)是由一种新发现的冠状病毒引起的传染病。很少有直接证据表明迷路炎是病毒引起的;然而,大量的流行病学证据表明,有几种病毒可能引起迷宫的炎症。病毒性迷路炎常以上呼吸道感染为先兆,常在流行病中发生。目的/目的:本研究比较无症状COVID-19 pcr阳性病例与正常非感染者前庭诱发肌源电位(VEMPs)潜伏期。材料与方法:20例COVID-19确诊阳性且无已知病毒感染症状的患者组成试验组,为期2周。他们的年龄在20-50岁之间,以避免任何与年龄相关的听力影响。有明确的COVID-19感染症状的患者以及有听力损失史或任何已知原因的听力损失史的患者被排除在检查样本之外。测量所有参与者的VEMPs潜伏期。结果:与对照组相比,VEMPs潜伏期明显增加,可以检测到囊毛细胞功能的恶化。结论及意义:COVID-19感染虽无症状,但可对前庭毛细胞功能产生剧烈影响。应随访COVID-19患者,以发现任何有关其前庭功能的投诉。这些作用的机理有待进一步研究。
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引用次数: 1
Clinical Approach for Diagnosis and Treatment of Burning Mouth Syndrome 灼口综合征的临床诊断与治疗方法
Pub Date : 2020-06-14 DOI: 10.19080/gjo.2020.22.556096
Y. Eltohami
Burning mouth syndrome [BMS] is a chronic pain condition, characterized by an intraoral burning sensation in the absence of any organic disorders of the oral cavity or clinical or laboratory findings, affecting predominantly postmenopausal middle‐aged females. This condition is probably of multifactorial origin, involving various local, systemic, and/or psychogenic causes, often idiopathic and its exact etiopathogenesis remains unclear. As the symptom of oral burning is seen in various pathological conditions, it is essential for a clinician to be aware of how to differentiate between symptom of oral burning and BMS as it is a disease of exclusion. With its management still remaining to be a challenge, In this article we discuss current management strategies from the use of pharmacological modalities to applying non-pharmacological modalities including cognitive behavioral therapy and complementary and alternative medicine [CAM], emphasizing the important role of patient education and anxiety management to improve the patients’ quality of life.
灼口综合征(BMS)是一种慢性疼痛疾病,以口腔内烧灼感为特征,无任何口腔器质性疾病或临床或实验室结果,主要影响绝经后中年女性。这种情况可能是多因素的,涉及各种局部、全身和/或心理原因,通常是特发性的,其确切的发病机制尚不清楚。由于口腔灼烧的症状出现在各种病理条件下,因此如何区分口腔灼烧与BMS是一种排他性疾病,对于临床医生来说至关重要。在这篇文章中,我们讨论了目前的管理策略,从使用药物模式到应用非药物模式,包括认知行为疗法和补充和替代医学[CAM],强调患者教育和焦虑管理在改善患者生活质量方面的重要作用。
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引用次数: 0
Effect of Social Media on Decision to Undergo Rhinoplasty 社交媒体对隆鼻决定的影响
Pub Date : 2020-06-11 DOI: 10.19080/gjo.2020.22.556094
Waleed M. Alghamdi
Background: Rhinoplasty is surgery for changing the shape of the nose and it may be motivated by the need to change the appearance of the nose, improve breathing, or both. Rhinoplasty can change the bone, cartilage, skin of the nose, or all three. When planning rhinoplasty, the surgeon will consider other facial features, the skin on the nose, and patient expectations. Aim: To assess the influence of social media on patients who underwent rhinoplasty, and determine if it was the main influence for their decision. Methods: A retrospective record-based descriptive approach was used to review the medical records of all patients who underwent rhinoplasty in Aseer Central Hospital (ACH) between 2015 and 2020. Data were obtained through pre-structured questionnaires and included patients’ bio-clinical data, indications, and effects of different social media platforms. Results: Hundred patients who underwent rhinoplasty, had complete medical files, and responded to phone calls were included. All the cases were aged above 18 years and 56% were men. Snapchat was the most used social media platform (57%), followed by WhatsApp (19%). Social media influenced more than 2/3 of the patients to undergo rhinoplasty. Approximately 58% of those influenced were males compared to 52.8% of those who were not. Instagram had the highest influence on male decisions to undergo rhinoplasty; its influence was significantly higher among females. Conclusions: The study revealed that social media platforms were used extensively, and they influenced patients’ decisions to undergo rhinoplasty mainly through the provision of news about famous people.
背景:鼻整形术是一种改变鼻子形状的手术,其动机可能是改变鼻子的外观,改善呼吸,或两者兼而有之。鼻整形术可以改变鼻子的骨骼、软骨、皮肤,或者三者都改变。在计划隆鼻手术时,外科医生会考虑其他面部特征、鼻子上的皮肤和患者的期望。目的:评估社交媒体对隆鼻患者的影响,并确定社交媒体是否是其决定的主要影响因素。方法:采用基于回顾性记录的描述性方法,回顾2015年至2020年在阿西尔中心医院(ACH)接受鼻整形手术的所有患者的医疗记录。数据通过预先结构化的问卷调查获得,包括患者的生物临床数据、适应症和不同社交媒体平台的效果。结果:纳入100例接受鼻整形手术、病历完整、电话应答的患者。所有病例年龄均在18岁以上,其中56%为男性。Snapchat是最常用的社交媒体平台(57%),其次是WhatsApp(19%)。社交媒体影响了超过2/3的患者接受隆鼻手术。受影响的人中约有58%是男性,而女性的比例为52.8%。Instagram对男性决定做隆鼻手术的影响最大;其对女性的影响更大。结论:研究表明,社交媒体平台被广泛使用,主要通过提供名人新闻来影响患者的隆鼻决定。
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引用次数: 6
Retrospective Analysis of Phonatory Outcomes after CO2 Laser Thyroarytenoid Myoneurectomy in Patients with Adductor Spasmodic Dysphonia 内收肌痉挛性发音障碍CO2激光类甲状腺肌神经切除术后发音效果的回顾性分析
Pub Date : 2020-06-08 DOI: 10.19080/gjo.2020.22.556091
R. Bidaye
Introduction: Adductor spasmodic dysphonia (ADSD) is a focal laryngeal dystonia characterized by spasms of laryngeal muscles during speech. Botulinum toxin injection in the Thyroarytenoid muscle remains the gold-standard treatment for ADSD. However, as Botulinum toxin injections need to be repeated periodically, the voice quality fluctuates over a longer period. A Microlaryngoscopic Transoral approach to CO2 laser Thyroarytenoid myoneurectomy (TAM) has been reported as an effective technique for treatment of ADSD. It provides sustained improvement in the voice over a longer duration. Methods : Trans oral Microlaryngoscopic CO2 laser TAM was performed in 14 patients (5 females and 9 males), aged between 19 and 64 years who were diagnosed with ADSD. Data was collected from over 3 years starting from Jan 2014 – Dec 2016. GRBAS scale along with Multidimensional voice programme (MDVP) analysis of the voice and Video laryngo-stroboscopic (VLS) samples at the end of 3 and 12 months of surgery would be compared with the pre-operative readings. Results: A total of 9 (64.2%) patients showed an improvement in grade after 3 months as well as 12 months after the surgery. While 12 (85.7%) patients showed an improvement in strain after 12 months of surgery. The spasms on VLS showed an improvement in 9 (64.3%) out of 14 cases after 3 months of surgery which was proven to be statistically significant. Conclusion : This innovative surgical technique is a good alternative treatment for ADSD patients who seek a definite improvement of their condition.
简介:内收肌痉挛性发音障碍(ADSD)是一种局灶性喉张力障碍,其特征是在说话时喉部肌肉痉挛。在甲状腺样肌注射肉毒杆菌毒素仍然是治疗ADSD的金标准。然而,由于肉毒杆菌毒素注射需要定期重复,因此声音质量在较长时间内波动。经口喉镜下CO2激光类甲状腺肌神经切除术(TAM)是治疗ADSD的一种有效方法。它能在更长的时间内持续改善声音。方法:对14例确诊为ADSD的患者(女5例,男9例)进行经口腔显微喉镜CO2激光TAM检查,年龄19 ~ 64岁。数据收集时间为2014年1月至2016年12月的3年多。在手术3个月和12个月结束时,将GRBAS量表以及语音和视频喉频闪(VLS)样本的多维语音程序(MDVP)分析与术前读数进行比较。结果:9例(64.2%)患者术后3个月及12个月评分均有改善。12例(85.7%)患者术后12个月劳损改善。手术3个月后,14例VLS患者中有9例(64.3%)痉挛得到改善,具有统计学意义。结论:这种创新的手术技术对于寻求病情改善的ADSD患者是一种很好的替代治疗方法。
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引用次数: 0
Nasal Cavity Actinomycosis Mimicking Nasal Cavity Tumor: A Case Report 模拟鼻腔肿瘤的鼻腔放线菌病1例报告
Pub Date : 2020-06-04 DOI: 10.19080/gjo.2020.22.556090
H. Ardhaoui
Actinomycosis is a chronic bacterial infection with granulomatous and suppurative features, caused by gram-positive anaerobic: actinomycetes. Generally, saprophytes of the natural cavities of man, but which can become pathogenic under certain conditions. This pathology is most common in the cervicofacial region. Involvement of the paranasal sinuses is extremely rare which can take on the appearance of tumor affections. We describe a case of nasal cavity actinomycosis diagnosed in 16-year female consulted for a left nasal airway obstruction associated with purulent rhinorrhea.
放线菌病是一种慢性细菌感染,伴有肉芽肿和化脓性特征,由革兰氏阳性厌氧放线菌引起。一般来说,腐生植物是人的天然蛀牙,但在某些条件下也会致病。这种病理最常见于颈面区。累及副鼻窦极为罕见,可表现为肿瘤病变。我们描述了一个病例的鼻腔放线菌病诊断在16岁的女性咨询左鼻气道阻塞与化脓性鼻漏。
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引用次数: 0
Landmark Discoveries in Calcium Metabolism Review of Literature 钙代谢的里程碑式发现
Pub Date : 2020-06-03 DOI: 10.19080/gjo.2020.22.556092
S. S
Calcium metabolism plays an integral role in maintaining homeostasis. Over 99% of the calcium present normally in the adult human body resides in the skeleton, where it provides mechanical stability and serves as a reservoir sometimes needed to maintain extracellular fluid (ECF) calcium concentration. Ionized calcium in the ECF must be maintained within a narrow range because of the critical role calcium plays in a wide array of cellular functions, especially in the neuromuscular activity, secretion, and signal transduction. Intracellular cytosolic free calcium levels are ~100nmol/L and are 10,000-fold lower than ionized calcium concentrations in the blood and ECF (1.1-1.3mmol/L). Cytosolic calcium does not play the structural role played by extracellular calcium; instead, it serves a signaling function. The steep chemical gradient of calcium from outside to inside the cell promotes rapid calcium influx through various membrane calcium channels that can be activated by hormones, metabolites, or neurotransmitters, swiftly changing cellular function. In blood, total calcium concentrations normally 2.2-2.6mM (8.5-10.5mg/dL), of which ~50% is ionized [1].
钙代谢在维持体内平衡中起着不可或缺的作用。正常情况下,成人体内99%以上的钙存在于骨骼中,骨骼提供了机械稳定性,有时还需要作为维持细胞外液(ECF)钙浓度的储存库。离子钙在ECF中必须保持在一个狭窄的范围内,因为钙在广泛的细胞功能中起着关键作用,特别是在神经肌肉活动、分泌和信号转导中。胞内游离钙水平为~100nmol/L,比血液和ECF中离子钙浓度(1.1 ~ 1.3mmol/L)低10000倍。胞质钙不发挥细胞外钙的结构作用;相反,它起着信号传递的作用。钙从细胞外到细胞内的陡峭化学梯度促进钙通过各种膜钙通道快速流入,这些通道可被激素、代谢物或神经递质激活,迅速改变细胞功能。血中总钙浓度正常为2.2-2.6mM (8.5-10.5mg/dL),其中约50%被电离[1]。
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引用次数: 1
Infection Control Process and Standard Precautions for Speech Language Pathologist at Acute Care Hospitals in COVID -19 Pandemic COVID -19大流行重症医院语言病理学家感染控制流程及标准预防措施
Pub Date : 2020-06-01 DOI: 10.19080/gjo.2020.22.556089
K. N
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引用次数: 0
Comparative Analysis of the Success Rate with the use of Fibrin Sealant in Tympanoplasty 纤维蛋白密封剂与鼓室成形术成功率的比较分析
Pub Date : 2020-05-26 DOI: 10.19080/gjo.2020.22.556088
R. Bidaye
Objective: To test the hypothesis that a Fibrin sealant (FS) can improve the success rate of Tympanoplasty surgery, a prospective trial was undertaken. The aim was to compare the graft uptake and hearing outcomes in type 1- Tympanoplasty with the use of a Fibrin sealant to secure the graft. Methods: A prospective study was performed on 80 patients within the age group of 18 to 64 years, from April 2014 to March 2016, at our institute. Otological examination and Audiometry findings were recorded with emphasis on the duration of symptoms, size of the perforation and the degree of hearing loss. Of the 80 patients undergoing type 1 Tympanoplasty with temporalis fascia graft, 40 patients (cases) underwent the surgery with the use of FS to secure the graft in place. The rest of the 40 patients (controls) served as a control group for this study. Statistical analysis was done using the Chi-square test. Results : In the post-operative results, the graft uptake success rate in cases was 95.00%, whereas the success rate in control group was 80.0%. This difference was statistically significant (Chi. Square=4.114, DF=1,p=0.043). Hearing outcome showed a statistically significant difference with predominance of normal hearing in cases (95.00%), whereas in the control group it was 77.50% (Chi. Square=6.155, DF=2,p=0.046). Conclusion: The FS improves the success rate in terms of graft uptake and hearing outcome in type 1 tympanoplasty.
目的:为验证纤维蛋白密封胶(FS)可提高鼓室成形术成功率的假设,进行了一项前瞻性试验。目的是比较1型鼓室成形术中使用纤维蛋白密封剂固定移植物的移植物摄取和听力结果。方法:对我院2014年4月至2016年3月80例年龄在18 ~ 64岁的患者进行前瞻性研究。记录耳科检查和听力学检查结果,重点记录症状持续时间、穿孔大小和听力损失程度。80例1型鼓室成形术伴颞筋膜移植物的患者中,40例(例)采用FS固定移植物。其余40例患者(对照组)作为本研究的对照组。统计学分析采用卡方检验。结果:术后移植成功率为95.00%,对照组为80.0%。这一差异有统计学意义。= 4.114平方,DF = 1, p = 0.043)。两组听力差异有统计学意义(95.00%),对照组听力差异有统计学意义(77.50%)。= 6.155平方,DF = 2, p = 0.046)。结论:FS在1型鼓室成形术中提高了移植物吸收的成功率和听力效果。
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引用次数: 0
Endoscopic Endonasal Trans-Sphenoidal and Skull Base Surgeries in Aseer Central Hospital, Sothern Saudi Arabia 沙特阿拉伯南部阿西尔中心医院的鼻内经蝶窦和颅底手术
Pub Date : 2020-05-21 DOI: 10.19080/gjo.2020.22.556087
A. Alskaini
Background: Over the Last 20 years, the transsphenoidal approach has been used to remove skull base tumors and also to reconstruct skull base in CSF leakage cases. With the development of endoscope technology and endoscopic surgery, resection of these Skull base tumors, like meningiomas, craniopharyngiomas, and large pituitary adenomas has been achieved by using endoscopic endonasal skull base (EESB) approaches. Many surgeons have reported the usefulness. Aim: Clinical assessment of endoscopic endonasal skull base surgeries for tumour resection or reconstructive purpose and also to evaluate development of skull base surgeries in southern region of Saudi Arabia. Methodology: A case series study was conducted in Division of Rhinology, Department of ORL HNS at Aseer central Hospital (ACH), Southern of Saudi Arabia. The study included all patients, who diagnosed with skull base lesion and CSF leakage and undergone endoscopic endonasal skull base surgeries over a period of 6 years. All records for identified cases were reviewed to find out the demographic data and surgeries related data. Results: The study included 20 cases whose ages ranged from 18 to 66 years old with mean age of 43.3 16.6 years old. Exact of 85% of the bases had tumour and 10% had traumatic injuries. Intra-operative CSF was recorded among 70% of the cases and 55% recorded complications while recurrence was recorded among 25% of the cases. Conclusion: In conclusion, the less invasive endoscopic endonasal approach of the skull base and the pituitary fossa is an innovative time saving surgeries with minimal complications. Better training for clinical skills and new techniques was recommended for all concerned surgeons.
背景:在过去的20年里,经蝶窦入路已被用于脑脊液漏病例的颅底肿瘤切除和颅底重建。随着内窥镜技术和内窥镜手术的发展,脑膜瘤、颅咽管瘤、垂体大腺瘤等颅底肿瘤已通过内镜鼻内颅底(EESB)入路切除。许多外科医生都报道了它的实用性。目的:评价鼻内窥镜颅底肿瘤切除或重建手术的临床效果,评价沙特阿拉伯南部地区颅底手术的发展。方法:在沙特阿拉伯南部阿西尔中心医院(ACH) ORL HNS部鼻科进行了一项病例系列研究。本研究纳入了所有诊断为颅底病变和脑脊液渗漏并在6年内行鼻内窥镜颅底手术的患者。对所有确诊病例的记录进行回顾,找出人口统计数据和手术相关数据。结果:本组病例20例,年龄18 ~ 66岁,平均年龄43.3 ~ 16.6岁。大约85%的基底有肿瘤,10%有外伤。术中有脑脊液的病例占70%,有并发症的占55%,有复发的占25%。结论:颅底垂体窝经鼻内窥镜入路微创手术是一种新颖、省时、并发症少的手术方式。建议所有相关外科医生加强临床技能和新技术的培训。
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引用次数: 0
From COVID to Cancer, is Vitamin C the Answer? 从COVID到癌症,维生素C是答案吗?
Pub Date : 2020-05-07 DOI: 10.19080/gjo.2020.22.556085
Anita Vazquez Tibau
The controversy between pharmaceutical drugs and supplements is ever present in global society, especially now, in the media during the current Covid-19 virus. One of the most important, yet, provocative supplements is vitamin C. While historically, its positive benefits have long been known, during the last decades the push for pharmaceutical drugs, instead of supplements like vitamin C, has created a heated debate against this, and other very affordable supplements. The majority of primates, including humans, guinea pigs, some birds and fish do not make vitamin C, however, most mammals are able to synthesize it in their liver or kidneys. The result of this genetic mutation in humans, therefore, requires vitamin C to be consumed through dietary sources. Clinical studies indicate that vitamin C neither increases nor reduces the occurrence of kidney stones, it also has no mutagenic effect with up to 5000mg per day [1].
药物和补品之间的争议一直存在于全球社会,特别是现在,在当前的Covid-19病毒期间,在媒体上。虽然从历史上看,维生素C的积极作用早已为人所知,但在过去的几十年里,对药物的推动,而不是像维生素C这样的补充剂,引发了一场激烈的辩论,反对维生素C和其他非常实惠的补充剂。大多数灵长类动物,包括人类、豚鼠、一些鸟类和鱼类不能制造维生素C,然而,大多数哺乳动物能够在肝脏或肾脏中合成维生素C。因此,人类这种基因突变的结果需要通过饮食来源摄入维生素C。临床研究表明,维生素C既不增加也不减少肾结石的发生,每天服用5000mg维生素C也无致突变作用[1]。
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引用次数: 0
期刊
Global Journal of Otolaryngology
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